Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.37
I. Kurganskiy, S. Lepekhova, O. A. Goldberg, L. Korobeynikova, E. Inozemtsev, Y. Pivovarov, E. Grigoryev
Background. Violation of the regeneration of the tracheal wall after undergoing reconstructive surgeries remains an urgent problem of modern surgery. One of the reasons for the violation of the regeneration processes is insufficient blood supply to the organ. Finding new ways to improve blood flow is a promising area of research. Aim. To evaluate the effectiveness of VEGF effect on the regeneration of the anterior tracheal surface in the early postoperative period. Materials and methods. The study included 60 male Wistar rats at the age of 10 months. All animals underwent tracheal reconstructive surgery; the animals were divided into three groups: group 1 – without medicinal film, group 2 – with prolonged-release medicinal film, group 3 – with prolonged-release medicinal film containing VEGF. The sampling of histological material was carried out on days 3, 7 and 21 of the study, using morphometry to determine the thickness of the tracheal wall, the thickness of the postoperative scar, the area of the surgical intervention zone, the area of the vessels, the ratio of the thickness of the postoperative scar to the wall thickness trachea and the ratio of the area of the vessels to the area of the surgical intervention zone. Results . It was revealed that when exposed to a long-acting medicinal film containing VEGF, significant histological changes occurred on day 7 of the study. In groups 1 and 2, healing occurred by day 21 and was accompanied by defects of the mucous membrane and cartilage. On day 7 in group 3, there was a complete epithelialization of the tracheal wall, an increase in the number of newly formed vessels and glands in the area of surgical intervention. Healing was carried out with a thin postoperative scar without defects in all layers of the tracheal wall. Conclusion . The results obtained indicate the stimulating effect of VEGF on the regeneration of the tracheal wall in the early postoperative period after undergoing reconstructive surgery. The use of VEGF reduces the time of postoperative wound healing and preserves the anatomical structure of the tracheal wall.
{"title":"Evaluation of the Effectiveness of VEGF Effect on the Regeneration of the Anterior Tracheal Surface in the Early Postoperative Period","authors":"I. Kurganskiy, S. Lepekhova, O. A. Goldberg, L. Korobeynikova, E. Inozemtsev, Y. Pivovarov, E. Grigoryev","doi":"10.29413/abs.2020-5.6.37","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.37","url":null,"abstract":"Background. Violation of the regeneration of the tracheal wall after undergoing reconstructive surgeries remains an urgent problem of modern surgery. One of the reasons for the violation of the regeneration processes is insufficient blood supply to the organ. Finding new ways to improve blood flow is a promising area of research. Aim. To evaluate the effectiveness of VEGF effect on the regeneration of the anterior tracheal surface in the early postoperative period. Materials and methods. The study included 60 male Wistar rats at the age of 10 months. All animals underwent tracheal reconstructive surgery; the animals were divided into three groups: group 1 – without medicinal film, group 2 – with prolonged-release medicinal film, group 3 – with prolonged-release medicinal film containing VEGF. The sampling of histological material was carried out on days 3, 7 and 21 of the study, using morphometry to determine the thickness of the tracheal wall, the thickness of the postoperative scar, the area of the surgical intervention zone, the area of the vessels, the ratio of the thickness of the postoperative scar to the wall thickness trachea and the ratio of the area of the vessels to the area of the surgical intervention zone. Results . It was revealed that when exposed to a long-acting medicinal film containing VEGF, significant histological changes occurred on day 7 of the study. In groups 1 and 2, healing occurred by day 21 and was accompanied by defects of the mucous membrane and cartilage. On day 7 in group 3, there was a complete epithelialization of the tracheal wall, an increase in the number of newly formed vessels and glands in the area of surgical intervention. Healing was carried out with a thin postoperative scar without defects in all layers of the tracheal wall. Conclusion . The results obtained indicate the stimulating effect of VEGF on the regeneration of the tracheal wall in the early postoperative period after undergoing reconstructive surgery. The use of VEGF reduces the time of postoperative wound healing and preserves the anatomical structure of the tracheal wall.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87713770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.16
L. Rodionova, L. G. Samoilova, S. Bogorodskaya, V. Gorokhova, V. Sorokovikov
{"title":"Molecular Genetic Studies of Intraoperative Ligamentum Flavum Bioptates of Patients with Spinal Canal Stenosis","authors":"L. Rodionova, L. G. Samoilova, S. Bogorodskaya, V. Gorokhova, V. Sorokovikov","doi":"10.29413/abs.2020-5.6.16","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.16","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89612577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.22
M. Kuzmin, L. Suturina
The article analyzes the problem of development of coping strategies as one of the factors of correction of psychoemotional disorders in women with hyperandrogenia. The nature of coping strategies is analyzed. Two approaches to the development of coping strategies – the concept of mindfulness, proposed by John Kabat-Zinn, and the concept of hardiness, proposed by S. Maddi. In conception of Kabat-Zinn mindfulness involves a feeling of full involvement in the events “here and now”, as well as the obligation to be curious about the flow of consciousness: all thoughts and feelings that arise in the person should be perceived by it without criticism, as relevant to the current state and therefore do not require condemnation. At the same time, by S. Muddy hardiness is a combination of inclusion in the surrounding reality (commitment), control, denoting the belief of the individual in their own abilities to influence the stressful situation, although without certain guarantees of the result, and the challenge, representing the belief that any changes are fundamentally positive for the individual and contribute to its development. It is shown that the content of the category of mindfulness – the management of attention and the adoption of the position “here and now” – as well as the methods of its development, are similar in each of the concepts. It is concluded that mindfulness, which is the core of productive coping strategies, is a set of concentration skills and a certain attitude.
{"title":"The Development of Coping Strategies: Main Approaches","authors":"M. Kuzmin, L. Suturina","doi":"10.29413/abs.2020-5.6.22","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.22","url":null,"abstract":"The article analyzes the problem of development of coping strategies as one of the factors of correction of psychoemotional disorders in women with hyperandrogenia. The nature of coping strategies is analyzed. Two approaches to the development of coping strategies – the concept of mindfulness, proposed by John Kabat-Zinn, and the concept of hardiness, proposed by S. Maddi. In conception of Kabat-Zinn mindfulness involves a feeling of full involvement in the events “here and now”, as well as the obligation to be curious about the flow of consciousness: all thoughts and feelings that arise in the person should be perceived by it without criticism, as relevant to the current state and therefore do not require condemnation. At the same time, by S. Muddy hardiness is a combination of inclusion in the surrounding reality (commitment), control, denoting the belief of the individual in their own abilities to influence the stressful situation, although without certain guarantees of the result, and the challenge, representing the belief that any changes are fundamentally positive for the individual and contribute to its development. It is shown that the content of the category of mindfulness – the management of attention and the adoption of the position “here and now” – as well as the methods of its development, are similar in each of the concepts. It is concluded that mindfulness, which is the core of productive coping strategies, is a set of concentration skills and a certain attitude.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79927676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Sharifulin, I. A. Igumnov, O. Krusko, A. Atalyan, L. Suturina
{"title":"Features of Chronic Endometritis in Women of Reproductive Age with Polycystic Ovary Syndrome","authors":"E. Sharifulin, I. A. Igumnov, O. Krusko, A. Atalyan, L. Suturina","doi":"10.29413/abs.2020-5.6.3","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.3","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77124674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.18
I. Vasilyev, I. Pendyurin, A. Buzunov, S. V. Tsvetkovskiy, E. V. Stupak, V. Stupak
{"title":"An Hourglass-Type Spinal Schwannoma Spreading to the Chest Treated with One-Stage Total Removal through Posterior Paravertebral Approach without Opening the Pleural Cavity (Clinical Observation)","authors":"I. Vasilyev, I. Pendyurin, A. Buzunov, S. V. Tsvetkovskiy, E. V. Stupak, V. Stupak","doi":"10.29413/abs.2020-5.6.18","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.18","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87056773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.25
V. Monastyrev, N. Ponomarenko, N. Tishkov
{"title":"Using an Autograft from the Fibula Diaphysis in the Surgical Treatment of Patients with Fractures of the Proximal Humerus on the Background of Critical Osteoporosis","authors":"V. Monastyrev, N. Ponomarenko, N. Tishkov","doi":"10.29413/abs.2020-5.6.25","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.25","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79015396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modern Concepts of Clinical and Diagnostic Criteria for Premature Ovarian Failure (Literature Review)","authors":"M. Salimova, Ya. G. Nadelyaeva, I. Danusevich","doi":"10.29413/abs.2020-5.6.5","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.5","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89913123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.19
V. Rerikh, E. V. Dubinin
Using a clinical example, the authors set the goal of elucidating the result of a two-stage surgical treatment of An- derson’s lesion, carried out in the long-term period after a one-stage correction of flexion deformity of the ankylosed spine without fixation. Results. The analysis of the results of treatment three years after decompression-corrective stabilizing surgery performed for Anderson’s lesion at the Th X –Th XI level, which developed 10 years after the correction of flexion deformity of the ankylosed spine by “open” vertebrotomy L IV –L V . No progression of Anderson’s lesion in all previously identified vertebral segments was noted. The existing neurological deficit regressed from ASIA C to ASIA E. Normalization of the SVA sagittal balance parameter was revealed, with preserved local kyphosis at the Th X –Th XI level of 15° (initial – 30°). The indicator ODI (Oswestry Disability Index), VAS and FIM (Functional Independence Measure) were, respectively, before surgery 67, 6 and 82, 3 years after surgery – 10, 0 and 126. Conclusion. In the presented case, the surgical correction of the deformity, carried out taking into account the param-eters of the sagittal balance, with the stabilization of the ventral and dorsal columns, and decompression, made it possible to prevent the progression of Andersson’s lesion, achieve regression of neurological symptoms, and improve the patient’s quality of life.
{"title":"Surgical Treatment of Andersson’s Lesion in Ankylosing Spondylitis after Corrective Vertebrotomy in the Long Term (Clinical Observation)","authors":"V. Rerikh, E. V. Dubinin","doi":"10.29413/abs.2020-5.6.19","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.19","url":null,"abstract":"Using a clinical example, the authors set the goal of elucidating the result of a two-stage surgical treatment of An- derson’s lesion, carried out in the long-term period after a one-stage correction of flexion deformity of the ankylosed spine without fixation. Results. The analysis of the results of treatment three years after decompression-corrective stabilizing surgery performed for Anderson’s lesion at the Th X –Th XI level, which developed 10 years after the correction of flexion deformity of the ankylosed spine by “open” vertebrotomy L IV –L V . No progression of Anderson’s lesion in all previously identified vertebral segments was noted. The existing neurological deficit regressed from ASIA C to ASIA E. Normalization of the SVA sagittal balance parameter was revealed, with preserved local kyphosis at the Th X –Th XI level of 15° (initial – 30°). The indicator ODI (Oswestry Disability Index), VAS and FIM (Functional Independence Measure) were, respectively, before surgery 67, 6 and 82, 3 years after surgery – 10, 0 and 126. Conclusion. In the presented case, the surgical correction of the deformity, carried out taking into account the param-eters of the sagittal balance, with the stabilization of the ventral and dorsal columns, and decompression, made it possible to prevent the progression of Andersson’s lesion, achieve regression of neurological symptoms, and improve the patient’s quality of life.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82277125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.24
A. N. Grishchuk, S. Leonova, A. Kameka
{"title":"Using an Algorithm to Choose the Surgical Tactics for the Treatment of Periprosthetic Infection of Large Joints","authors":"A. N. Grishchuk, S. Leonova, A. Kameka","doi":"10.29413/abs.2020-5.6.24","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.24","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88089488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.12
E. Grigorova, L. Rychkova, L. Sholokhov, N. Belkova, U. Nemchenko, E. Kungurtseva, N. Voropaeva, M. V. Savelkayeva
Background. The development of functional gastrointestinal disorders (FGID) in children, especially in the first year of life, is a key factor in the formation of an altered colon microbiota and its formation in older age. The article presents both clinical-detailed anamnesis, symptoms of FGID, and bacteriological characteristics – qualitative and quantitative composition of the colon microbiota in children of the first year of life. Aim: to determine the features of the colon microbiota in children of the first year of life with FGID. Materials and methods. The objects of the study were children of the first year of life (n = 28) with a diagnosis of FGID established by a gastroenterologist. The material was divided into two comparison groups, depending on the age of the subjects: the first group included stool sample cultures of children aged from birth to 6 months (n = 17), the second – from 6 to 12 months (n = 11). The bacteriological study of the quantitative and qualitative composition of the contents of the colon was performed using standard methods. Results. According to the anamnesis, colic and flatulence were the key symptoms of FGID (p < 0.05). The results show that the formation of FGID in children from birth to 6 months and from 6 to 12 months may be associated with altered colon microbiota. There was a decrease in the quantitative indicators of the indigenous microbiota: bifidobacteria, E. coli with normal sensitivity and Enterococcus spp., and an increase in the degree of contamination of Klebsiella spp., S. aureus, Clostridium spp. Conclusion. It is shown that the determining factor in reducing the risk of developing FGID in children of the first year of life is a high concentration and diversity of indigenous microbiota.
{"title":"Features of the Composition of the Colon Microbiota in Children of the First Year of Life with Functional Gastrointestinal Disorders","authors":"E. Grigorova, L. Rychkova, L. Sholokhov, N. Belkova, U. Nemchenko, E. Kungurtseva, N. Voropaeva, M. V. Savelkayeva","doi":"10.29413/abs.2020-5.6.12","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.12","url":null,"abstract":"Background. The development of functional gastrointestinal disorders (FGID) in children, especially in the first year of life, is a key factor in the formation of an altered colon microbiota and its formation in older age. The article presents both clinical-detailed anamnesis, symptoms of FGID, and bacteriological characteristics – qualitative and quantitative composition of the colon microbiota in children of the first year of life. Aim: to determine the features of the colon microbiota in children of the first year of life with FGID. Materials and methods. The objects of the study were children of the first year of life (n = 28) with a diagnosis of FGID established by a gastroenterologist. The material was divided into two comparison groups, depending on the age of the subjects: the first group included stool sample cultures of children aged from birth to 6 months (n = 17), the second – from 6 to 12 months (n = 11). The bacteriological study of the quantitative and qualitative composition of the contents of the colon was performed using standard methods. Results. According to the anamnesis, colic and flatulence were the key symptoms of FGID (p < 0.05). The results show that the formation of FGID in children from birth to 6 months and from 6 to 12 months may be associated with altered colon microbiota. There was a decrease in the quantitative indicators of the indigenous microbiota: bifidobacteria, E. coli with normal sensitivity and Enterococcus spp., and an increase in the degree of contamination of Klebsiella spp., S. aureus, Clostridium spp. Conclusion. It is shown that the determining factor in reducing the risk of developing FGID in children of the first year of life is a high concentration and diversity of indigenous microbiota.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81458644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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