Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.35
S. Bogorodskaya, A. A. Runovich
{"title":"To the Mechanism of Adrenaline Damage to the Heart Tissue and the Mechanism of Cardioprotection by Neonatal, Xenogenic, Cardiac Cells. Dynamics of Creatine Phosphate, Lactate and Malondialdehyde","authors":"S. Bogorodskaya, A. A. Runovich","doi":"10.29413/abs.2020-5.6.35","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.35","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78354856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Mechanisms of Endometrial Functioning in Women with Polycystic Ovary Syndrome","authors":"A. Y. Sambyalova","doi":"10.29413/abs.2020-5.6.1","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.1","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81678031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.11
A. V. Nevezhina
{"title":"Carbapenemases as factors of Resistance to Antibacterial Drugs","authors":"A. V. Nevezhina","doi":"10.29413/abs.2020-5.6.11","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.11","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77763088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Krusko, M. Rashidova, A. Brichagina, E. Sharifulin, L. Belenkaya
Background. Women with polycystic ovary syndrome in the early reproductive period have hormonal and metabolic dysfunction and an increased risk of long-term health consequences. The article presents the results of the study of hor - monal indicators and the parameters of lipid peroxidation – antioxidant protection in women with polycystic ovary syndrome in early period of reproductive age (from 18 to 35 years old). Aim: evaluation of the functional state of the pituitary-ovarian-adrenal system and the lipid peroxidation – antioxidant protection system and the establishment of intersystemic relationships in women of the early reproductive period with polycystic ovary syndrome. Materials and methods. Study included 33 women with ovarian hyperandrogenism and 17 healthy women of early reproductive age. A questionnaire survey, general medical and gynecological examinations, and ultrasound examination of the pelvic organs were conducted. Immunoenzyme method for detection the concentration of hormones, spectro - photometric and spectrofluorometric (determination of the concentration of lipoperoxidation products, parameters of antioxidant protection), statistical methods were used. Results. Women of early reproductive age (from 18 to 35 years old) with polycystic ovary syndrome characterized by an increase of 17-OH-progesterone by 2.2 times (p = 0.0005), and dehydroepiandrosterone sulfate by 1.3 times (p = 0.0001). A decrease in the total antioxidant activity of the blood by 25 % (p = 0.0005), an increase in the content of oxidized glutathione by 14 % (p = 0.0001) and a decrease in the concentration of retinol by 26 % (p = 0.0012) com pared to the control values were shown. The increase in the degree of oxidative stress was indicated by the value of the coefficient of oxidative stress equal to 2.8. Conclusion. The obtained data indicate the features of the functional state of the pituitary-ovarian-adrenal system and the processes of LPO–AOP, as well as the need for timely diagnosis and effective correction of hormonal and metabolic disorders in women with polycystic ovary syndrome in the early reproductive period. Features of the Functional State of the Hy-pophysis-Ovarian System and Processes of Lipid Peroxidation – Antioxidant Protection in Women with Hyperandrogenism of Ovary Genesis in the Early Reproductive Period.
{"title":"Features of the Functional State of the Hypophysis-Ovarian System and Processes of Lipid Peroxidation – Antioxidant Protection in Women with Hyperandrogenism of Ovary Genesis in the Early Reproductive Period","authors":"O. Krusko, M. Rashidova, A. Brichagina, E. Sharifulin, L. Belenkaya","doi":"10.29413/abs.2020-5.6.2","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.2","url":null,"abstract":"Background. Women with polycystic ovary syndrome in the early reproductive period have hormonal and metabolic dysfunction and an increased risk of long-term health consequences. The article presents the results of the study of hor - monal indicators and the parameters of lipid peroxidation – antioxidant protection in women with polycystic ovary syndrome in early period of reproductive age (from 18 to 35 years old). Aim: evaluation of the functional state of the pituitary-ovarian-adrenal system and the lipid peroxidation – antioxidant protection system and the establishment of intersystemic relationships in women of the early reproductive period with polycystic ovary syndrome. Materials and methods. Study included 33 women with ovarian hyperandrogenism and 17 healthy women of early reproductive age. A questionnaire survey, general medical and gynecological examinations, and ultrasound examination of the pelvic organs were conducted. Immunoenzyme method for detection the concentration of hormones, spectro - photometric and spectrofluorometric (determination of the concentration of lipoperoxidation products, parameters of antioxidant protection), statistical methods were used. Results. Women of early reproductive age (from 18 to 35 years old) with polycystic ovary syndrome characterized by an increase of 17-OH-progesterone by 2.2 times (p = 0.0005), and dehydroepiandrosterone sulfate by 1.3 times (p = 0.0001). A decrease in the total antioxidant activity of the blood by 25 % (p = 0.0005), an increase in the content of oxidized glutathione by 14 % (p = 0.0001) and a decrease in the concentration of retinol by 26 % (p = 0.0012) com pared to the control values were shown. The increase in the degree of oxidative stress was indicated by the value of the coefficient of oxidative stress equal to 2.8. Conclusion. The obtained data indicate the features of the functional state of the pituitary-ovarian-adrenal system and the processes of LPO–AOP, as well as the need for timely diagnosis and effective correction of hormonal and metabolic disorders in women with polycystic ovary syndrome in the early reproductive period. Features of the Functional State of the Hy-pophysis-Ovarian System and Processes of Lipid Peroxidation – Antioxidant Protection in Women with Hyperandrogenism of Ovary Genesis in the Early Reproductive Period.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76782285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.30
M. Kosareva, S. Leonova
Introduction. The urgency of the problem of surgical treatment of hammer-like deformity of the toes is due to the incidence of pathology, the presence of unsatisfactory results and postoperative complications. Objective. Analysis of scientific literature devoted to the problems of surgical treatment of hammer deformities of the toes. Materials. Analyzed domestic and foreign scientific publications on the classification and surgical treatment of ham - mer toes. Results. The article presents an analysis of the classifications of hammer-like deformity of the toes and instability of the metatarsophalangeal joints and an analysis of treatment methods aimed at eliminating various manifestations of deformity, with a description of the complications that have arisen. The systematization of methods for correcting hammer-like deformity of the toes was carried out. Conclusion. Analysis of the literature data allowed us to determine that the problems of treating hammer-like defor - mity of the toes are associated with the lack of a classification that would reflect the condition of the forefoot of each individual patient and allow choosing the optimal effective methods of treatment, as well as an algorithm for choosing tactics for surgical treatment of hammer-like deformity, which systematizes the methods treatment depending on the manifestations of deformity of the entire forefoot.
{"title":"Problems of Surgical Treatment of Hammer Toes (Review of Literature)","authors":"M. Kosareva, S. Leonova","doi":"10.29413/abs.2020-5.6.30","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.30","url":null,"abstract":"Introduction. The urgency of the problem of surgical treatment of hammer-like deformity of the toes is due to the incidence of pathology, the presence of unsatisfactory results and postoperative complications. Objective. Analysis of scientific literature devoted to the problems of surgical treatment of hammer deformities of the toes. Materials. Analyzed domestic and foreign scientific publications on the classification and surgical treatment of ham - mer toes. Results. The article presents an analysis of the classifications of hammer-like deformity of the toes and instability of the metatarsophalangeal joints and an analysis of treatment methods aimed at eliminating various manifestations of deformity, with a description of the complications that have arisen. The systematization of methods for correcting hammer-like deformity of the toes was carried out. Conclusion. Analysis of the literature data allowed us to determine that the problems of treating hammer-like defor - mity of the toes are associated with the lack of a classification that would reflect the condition of the forefoot of each individual patient and allow choosing the optimal effective methods of treatment, as well as an algorithm for choosing tactics for surgical treatment of hammer-like deformity, which systematizes the methods treatment depending on the manifestations of deformity of the entire forefoot.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78048800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.21
A. Romanitsa, V. Polyakov, A. Pogodina, N. A. Myasishchev, Y. Klimkina, L. Rychkova
Background. Obesity and its complications continue to be a serious problem in children and adolescents in the 21st century. Clinical and psychological studies show that obesity may lead to changes in emotional status of adolescents. Today exposure to sociodemographic parameters is known to be a risk factor for the development of obesity in chil- dren. Thus, our research focuses on the relationship between sociodemographic and psychological factors and obesity in adolescents, as this link has not been sufficiently studied. Aim. To determine sociodemographic and psychological factors associated with adolescent obesity. Materials and methods/ Our cross-sectional study included 111 obese adolescents and 39 normal weight adolescents, aged 11–17 years. We used anthropometry and questionnaire methods to examine emotional state, eating habits and socio-demographic characteristics of teenagers. Results. It is shown that adolescents with obesity are more likely than adolescents with normal weight to have a step-parent (p = 0.002). All adolescents with normal weight were involved in extracurricular activities and attended dif-* ferent courses (studying with tutors, going to language schools, exam preparation courses), compared to adolescents with obesity (75 %) (p < 0.001). We did not find any differences between the groups in the domains of sports activities and screen time. When examining the emotional state of adolescents, we found that more people from the group with obesity suffered from lower self-esteem than from the control group (p = 0.041). Adolescents with obesity tend to have (15.3 %) severe depression, while no controls reported this issue. Conclusions. We found that adolescents with obesity more often live in a step-family. They are less likely to be engaged in additional educational activities. We succeeded to describe the emotional status and eating habits of obese adolescents.
{"title":"Obese Adolescent: Social and Psychological Portrait","authors":"A. Romanitsa, V. Polyakov, A. Pogodina, N. A. Myasishchev, Y. Klimkina, L. Rychkova","doi":"10.29413/abs.2020-5.6.21","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.21","url":null,"abstract":"Background. Obesity and its complications continue to be a serious problem in children and adolescents in the 21st century. Clinical and psychological studies show that obesity may lead to changes in emotional status of adolescents. Today exposure to sociodemographic parameters is known to be a risk factor for the development of obesity in chil- dren. Thus, our research focuses on the relationship between sociodemographic and psychological factors and obesity in adolescents, as this link has not been sufficiently studied. Aim. To determine sociodemographic and psychological factors associated with adolescent obesity. Materials and methods/ Our cross-sectional study included 111 obese adolescents and 39 normal weight adolescents, aged 11–17 years. We used anthropometry and questionnaire methods to examine emotional state, eating habits and socio-demographic characteristics of teenagers. Results. It is shown that adolescents with obesity are more likely than adolescents with normal weight to have a step-parent (p = 0.002). All adolescents with normal weight were involved in extracurricular activities and attended dif-* ferent courses (studying with tutors, going to language schools, exam preparation courses), compared to adolescents with obesity (75 %) (p < 0.001). We did not find any differences between the groups in the domains of sports activities and screen time. When examining the emotional state of adolescents, we found that more people from the group with obesity suffered from lower self-esteem than from the control group (p = 0.041). Adolescents with obesity tend to have (15.3 %) severe depression, while no controls reported this issue. Conclusions. We found that adolescents with obesity more often live in a step-family. They are less likely to be engaged in additional educational activities. We succeeded to describe the emotional status and eating habits of obese adolescents.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86119889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.15
A. Brichagina, N. Semenova, I. Madaeva
{"title":"Glutathione System in Sleep Disorders (Literature Review)","authors":"A. Brichagina, N. Semenova, I. Madaeva","doi":"10.29413/abs.2020-5.6.15","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.15","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84518752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Lysosomes in the Cancer Progression: Focus on the Extracellular Matrix Degradation","authors":"I. Trukhan, N. Dremina, I. Shurygina","doi":"10.29413/abs.2020-5.6.9","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.9","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86142741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.39
E. D. Kazantseva, A. Petrova, A. S. Vanyarkinа, T. Bayanova, E. Novikova
Today in Irkutsk region, we face a noticeable increase in the number of cases of ixodid tick sucking to urban residents. Ticks, found in the territory of Irkutsk city, were detected to have all currently known pathogens causing such serious diseases as tick-borne encephalitis, tick-borne borreliosis, monocytic ehrlichiosis, granulocytic anaplasmosis, rickett- siosis and tick-borne recurrent fever. These diseases may develop to severe forms, and lead to disability or even death. The aim of the study was to evaluate the opinion of parents and doctors on vaccination against tick-borne viral encephalitis in Irkutsk based on the data of an anonymous questionnaire survey. Material and methods. The descriptive retrospective epidemiological study was conducted between November 2018 and January 2019. It included 1620 parents and 193 doctors of various specialties in Irkutsk. Statistical processing of the material was carried out using Excel tables (Windows 2010) and the Statistica 6.0 program. Results and discussion. In general, the attitude towards vaccination looks positive – 98 % of the parents vaccinate their children. 11.3 % of parents vaccinate their children from tick-borne encephalitis, 23.3 % of doctors vaccinate themselves. Every fourth doctor vaccinates his child against this infection. Conclusion. Insufficient vaccination coverage against tick-borne encephalitis is noted both among the population and among doctors of Irkutsk. It is important to introduce health education for the population and to adopt new ways for improving the qualifications of doctors in immunization issues.
{"title":"Commitment of Parents and Doctors of Irkutsk City to Vaccination against Tick-Borne Encephalitis","authors":"E. D. Kazantseva, A. Petrova, A. S. Vanyarkinа, T. Bayanova, E. Novikova","doi":"10.29413/abs.2020-5.6.39","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.39","url":null,"abstract":"Today in Irkutsk region, we face a noticeable increase in the number of cases of ixodid tick sucking to urban residents. Ticks, found in the territory of Irkutsk city, were detected to have all currently known pathogens causing such serious diseases as tick-borne encephalitis, tick-borne borreliosis, monocytic ehrlichiosis, granulocytic anaplasmosis, rickett- siosis and tick-borne recurrent fever. These diseases may develop to severe forms, and lead to disability or even death. The aim of the study was to evaluate the opinion of parents and doctors on vaccination against tick-borne viral encephalitis in Irkutsk based on the data of an anonymous questionnaire survey. Material and methods. The descriptive retrospective epidemiological study was conducted between November 2018 and January 2019. It included 1620 parents and 193 doctors of various specialties in Irkutsk. Statistical processing of the material was carried out using Excel tables (Windows 2010) and the Statistica 6.0 program. Results and discussion. In general, the attitude towards vaccination looks positive – 98 % of the parents vaccinate their children. 11.3 % of parents vaccinate their children from tick-borne encephalitis, 23.3 % of doctors vaccinate themselves. Every fourth doctor vaccinates his child against this infection. Conclusion. Insufficient vaccination coverage against tick-borne encephalitis is noted both among the population and among doctors of Irkutsk. It is important to introduce health education for the population and to adopt new ways for improving the qualifications of doctors in immunization issues.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76580348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.29413/abs.2020-5.6.20
A. Shchuko, E. T. Novozhilova, O. Rozanova, L. Sholokhov
{"title":"Differential Reorganization of Structural Elements of the Iridociliary and Perenticular Zones in the Hydrodynamic Blocks Formation","authors":"A. Shchuko, E. T. Novozhilova, O. Rozanova, L. Sholokhov","doi":"10.29413/abs.2020-5.6.20","DOIUrl":"https://doi.org/10.29413/abs.2020-5.6.20","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75705516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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