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Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders. 脑脊液神经丝光可预测精神病和神经退行性疾病患者的纵向诊断变化。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2024-02-01 Epub Date: 2023-04-28 DOI: 10.1017/neu.2023.25
Matthew J Y Kang, Dhamidhu Eratne, Hannah Dobson, Charles B Malpas, Michael Keem, Courtney Lewis, Jasleen Grewal, Vivian Tsoukra, Christa Dang, Ramon Mocellin, Tomas Kalincik, Alexander F Santillo, Henrik Zetterberg, Kaj Blennow, Christiane Stehmann, Shiji Varghese, Qiao-Xin Li, Colin L Masters, Steven Collins, Samuel F Berkovic, Andrew Evans, Wendy Kelso, Sarah Farrand, Samantha M Loi, Mark Walterfang, Dennis Velakoulis

Objective: People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.

Methods: We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other.

Results: Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone.

Conclusions: CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.

目的:有神经精神症状的人往往迟迟得不到准确诊断。虽然脑脊液神经丝光(CSF NfL)有望区分神经退行性疾病(ND)和精神疾病(PSY),但其在具有诊断难度的人群中的纵向诊断准确性尚不清楚:我们收集了在神经精神科接受评估的患者的纵向诊断信息(平均值 = 36 个月),并将诊断结果分为神经退行性疾病/轻度认知障碍/其他神经系统疾病(ND/MCI/其他)和 PSY。我们预先设定 NfL > 582 pg/mL 为 ND/MCI/other 的指标:结果:23%的患者(49/212)的诊断类别从初步诊断变为最终诊断。NfL预测了其中92%(22/24)患者的最终诊断类别,并预测了88%(187/212)患者的最终诊断类别(ND/MCI/其他与PSY),而仅通过临床评估预测最终诊断类别的比例为77%(163/212):CSF NfL提高了诊断的准确性,有可能在实际环境中使用预先指定的临界值更早、更准确地做出诊断,为将NfL应用于临床实践增添了砝码。
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引用次数: 0
Rumination in bipolar disorder associated with brain network and behavioural measures of inhibitory executive control. 双相情感障碍患者的反刍与抑制性执行控制的大脑网络和行为测量有关。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2024-02-01 Epub Date: 2023-08-25 DOI: 10.1017/neu.2023.36
Tina Chou, Darin D Dougherty, Andrew A Nierenberg, Sharmin Ghaznavi

Objective: Rumination is a passive form of negative self-focused cognition that predicts depressive episodes for individuals with bipolar disorder (BD). Individuals with BD also have impaired inhibitory executive control; rumination in BD may therefore reflect executive dysfunction. We investigated the relationship between a neural measure of executive functioning (functional connectivity between the frontoparietal control network [FPCN] and the default mode network [DMN] during an effortful task), behavioural measures of executive functioning (the Behavior Rating Inventory of Executive Function) and rumination (the Ruminative Responses Scale).

Methods: Fifteen individuals with BD and fifteen healthy controls underwent MRI scans during mental distraction. Using CONN toolbox, between-network FPCN-DMN connectivity values were calculated. We conducted Pearson's r bivariate correlations between connectivity values, BRIEF and RRS scores.

Results: RRS scores were positively correlated with BRIEF Behavioral Regulation Index (BRI) scores. In individuals with BD, there was a positive correlation between FPCN-DMN functional connectivity during distraction and BRIEF BRI scores. FPCN-DMN functional connectivity was also positively correlated with RRS ruminative brooding scores. Healthy controls did not show significant correlations between these behavioural and neural measures of executive functioning and rumination.

Conclusion: For individuals with BD, the greater the tendency to ruminate and the higher the executive dysfunction, the stronger the connectivity between an executive control network and a network involved in rumination during an unrelated cognitive task. This could reflect continual attempts to inhibit ruminative thinking and shift back to the distraction task. Therefore, engagement in rumination may reflect failed inhibitory executive control.

目的:反刍是一种消极的自我关注认知形式,可预测双相情感障碍(BD)患者的抑郁发作。双相情感障碍患者的抑制性执行控制能力也会受损;因此,双相情感障碍患者的反刍可能反映了执行功能障碍。我们研究了执行功能的神经测量(努力任务中前额叶控制网络[FPCN]和默认模式网络[DMN]之间的功能连接)、执行功能的行为测量(执行功能行为评定量表)和反刍(反刍反应量表)之间的关系:方法:15 名 BD 患者和 15 名健康对照者在精神分散时接受了核磁共振成像扫描。使用 CONN 工具箱计算网络间 FPCN-DMN 连接值。我们在连通性值、BRIEF 和 RRS 评分之间进行了 Pearson's r 双变量相关性分析:结果:RRS评分与BRIEF行为调节指数(BRI)评分呈正相关。在BD患者中,分心时FPCN-DMN功能连接与BRIEF BRI评分呈正相关。FPCN-DMN功能连接与RRS反刍思索评分也呈正相关。健康对照组在执行功能和反刍的行为和神经测量之间没有显示出明显的相关性:结论:对于 BD 患者来说,反刍倾向越强、执行功能障碍越严重,执行控制网络与反刍网络之间在不相关的认知任务中的连接性就越强。这可能反映了人们不断试图抑制反刍思维,并转回到分散注意力的任务上。因此,反刍可能反映了抑制性执行控制的失败。
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引用次数: 0
Genetic risk scores associated with temperament clusters in Finnish depression patients. 芬兰抑郁症患者的遗传风险评分与气质聚类相关。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2024-02-01 Epub Date: 2023-09-04 DOI: 10.1017/neu.2023.33
Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikäinen, Vesa Paavonen, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampman

Objective: Cloninger's temperament dimensions have been studied widely in relation to genetics. In this study, we examined Cloninger's temperament dimensions grouped with cluster analyses and their association with single nucleotide polymorphisms (SNPs). This study included 212 genotyped Finnish patients from the Ostrobothnia Depression Study.

Methods: The temperament clusters were analysed at baseline and at six weeks from the beginning of the depression intervention study. We selected depression-related catecholamine and serotonin genes based on a literature search, and 59 SNPs from ten different genes were analysed. The associations of single SNPs with temperament clusters were studied. Using the selected genes, genetic risk score (GRS) analyses were conducted considering appropriate confounding factors.

Results: No single SNP had a significant association with the temperament clusters. Associations between GRSs and temperament clusters were observed in multivariate models that were significant after permutation analyses. Two SNPs from the DRD3 gene, two SNPs from the SLC6A2 gene, one SNP from the SLC6A4 gene, and one SNP from the HTR2A gene associated with the HHA/LRD/LP (high harm avoidance, low reward dependence, low persistence) cluster at baseline. Two SNPs from the HTR2A gene were associated with the HHA/LRD/LP cluster at six weeks. Two SNPs from the HTR2A gene and two SNPs from the COMT gene were associated with the HP (high persistence) cluster at six weeks.

Conclusion: GRSs seem to associate with an individual's temperament profile, which can be observed in the clusters used. Further research needs to be conducted on these types of clusters and their clinical applicability.

目的:Cloninger的气质维度已被广泛研究与遗传学有关。在这项研究中,我们通过聚类分析检验了Cloninger的气质维度及其与单核苷酸多态性(SNPs)的关系。这项研究包括212名来自鸵鸟抑郁症研究的基因型芬兰患者。方法:在基线和抑郁症干预研究开始后6周对气质聚类进行分析。我们在文献检索的基础上选择了与抑郁症相关的儿茶酚胺和血清素基因,并分析了来自10个不同基因的59个SNPs。研究了单个SNPs与气质簇的关系。使用选定的基因,进行遗传风险评分(GRS)分析,考虑适当的混杂因素。结果:没有一个SNP与气质聚类有显著的相关性。在排列分析后显著的多变量模型中观察到GRS和气质聚类之间的关联。两个来自DRD3基因的SNP,两个来自SLC6A2基因的SNPs,一个来自SLC6A4基因的SNPs,以及一个来自HTR2A基因的与基线时的HHA/LRD/LP(高伤害避免、低回报依赖、低持久性)簇相关的SNP。来自HTR2A基因的两个SNPs在6周时与HHA/LRD/LP簇相关。来自HTR2A基因的两个SNPs和来自COMT基因的两种SNPs在六周时与HP(高持久性)簇相关。结论:GRS似乎与个人的气质特征有关,这可以在所使用的聚类中观察到。需要对这些类型的集群及其临床适用性进行进一步的研究。
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引用次数: 0
Group independent components underpin responses to items from a depression scale. 群体独立成分是对抑郁量表项目反应的基础。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2024-02-01 Epub Date: 2023-04-24 DOI: 10.1017/neu.2023.22
Drozdstoy Stoyanov, Vladimir Khorev, Rossitsa Paunova, Sevdalina Kandilarova, Semen Kurkin, Vince D Calhoun

Objective: The aim of the present study is to investigate the brain circuits or networks that underpin diagnostically specific tasks by means of group independent component analysis for FMRI toolbox (GIFT). We hypothesised that there will be neural network patterns of activation and deactivation, which correspond to real-time performance on clinical self-evaluation scales.

Methods: In total, 20 healthy controls (HC) and 22 patients with major depressive episode have been included. All subjects were scanned with functional magnetic resonance imaging (fMRI) with paradigm composed of diagnostic clinical self-assessment depression scale contrasted to neutral scale. The data were processed with group independent component analysis for functional MRI toolbox and statistical parametric mapping.

Results: The results have demonstrated that there exist positively or negatively modulated brain networks during processing of diagnostic specific task questions for depressive disorder. There have also been confirmed differences in the networks processing diagnostic versus off blocks between patients and controls in anterior cingulate cortex and middle frontal gyrus. Diagnostic conditions (depression scale) when contrasted to neutral conditions demonstrate differential activity of right superior frontal gyrus and right middle cingulate cortex in the comparison of patients with HC.

Conclusion: Potential neuroimaging of state-dependent biomarkers has been directly linked with clinical assessment self-evaluation scale, administered as stimuli simultaneously with the fMRI acquisition. It may be regarded as further evidence in support of the convergent capacity of both methods to distinguish groups by means of incremental translational cross-validation.

研究目的本研究旨在通过FMRI工具箱(GIFT)的组独立成分分析,研究支撑特定诊断任务的大脑回路或网络。我们假设,激活和失活的神经网络模式与临床自我评估量表的实时表现相对应:方法:共纳入 20 名健康对照组(HC)和 22 名重度抑郁症患者。所有受试者均接受了功能磁共振成像(fMRI)扫描,范式由诊断性临床自我评估抑郁量表和中性量表组成。数据经功能磁共振成像工具箱的组独立成分分析和统计参数映射处理:结果表明,在处理抑郁障碍的特定诊断任务问题时,大脑网络存在正向或负向调节。在前扣带回皮层和额叶中回,患者和对照组在处理诊断与非诊断区块时的网络差异也得到了证实。诊断性条件(抑郁量表)与中性条件的对比显示,在患者与对照组的对比中,右侧额上回和右侧扣带中叶皮层的活动存在差异:状态依赖性生物标志物的潜在神经成像与临床评估的自我评价量表直接相关,在进行 fMRI 采集的同时进行刺激。这可以被视为支持这两种方法通过增量转化交叉验证来区分群体的趋同能力的进一步证据。
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引用次数: 0
Neuropeptide Y gene variants and Agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism. 神经肽 Y 基因变异与合意性:与出生队列和血清素转运体启动子多态性的交互效应。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2024-02-01 Epub Date: 2023-04-18 DOI: 10.1017/neu.2023.23
Evelyn Kiive, Margus Kanarik, Toomas Veidebaum, Jaanus Harro

Objective: Neuropeptide Y (NPY) is a powerful regulator of anxious states, including social anxiety, but evidence from human genetic studies is limited. Associations of common gene variants with behaviour have been described as subject to birth cohort effects, especially if the behaviour is socially motivated. This study aimed to examine the association of NPY rs16147 and rs5574 with personality traits in highly representative samples of two birth cohorts of young adults, the samples having been formed during a period of rapid societal transition.

Methods: Both birth cohorts (original n = 1238) of the Estonian Children Personality Behaviour and Health Study (ECPBHS) self-reported personality traits of the five-factor model at 25 years of age.

Results: A significant interaction effect of the NPY rs16147 and rs5574 and birth cohort on Agreeableness was found. The T/T genotype of NPY rs16147 resulted in low Agreeableness in the older cohort (born 1983) and in high Agreeableness in the younger cohort (born 1989). The C/C genotype of NPY rs5574 was associated with higher Agreeableness in the younger but not in the older cohort. In the NPY rs16147 T/T homozygotes, the deviations from average in Agreeableness within the birth cohort were dependent on the serotonin transporter promoter polymorphism.

Conclusions: The association between the NPY gene variants and a personality domain reflecting social desirability is subject to change qualitatively in times of rapid societal changes, serving as an example of the relationship between the plasticity genes and environment. The underlying mechanism may involve the development of the serotonergic system.

目的:神经肽 Y(Neuropeptide Y,NPY)是焦虑状态(包括社交焦虑)的一个强有力的调节因子,但人类基因研究的证据却很有限。常见的基因变异与行为的关联被描述为受出生队列效应的影响,尤其是当行为是由社会因素引起时。本研究的目的是在两个具有高度代表性的青壮年出生队列样本中研究 NPY rs16147 和 rs5574 与人格特质的关联,这两个出生队列样本是在社会快速转型时期形成的:方法:爱沙尼亚儿童人格行为与健康研究(ECPBHS)的两个出生队列(原始 n = 1238)都对 25 岁时的五因素模型人格特质进行了自我报告:结果发现,NPY rs16147和rs5574与出生队列对 "宜人性 "有明显的交互效应。NPY rs16147的T/T基因型会导致年长组群(1983年出生)中的低度 "合群性 "和年轻组群(1989年出生)中的高度 "合群性"。NPY rs5574的C/C基因型在年轻组群中与较高的可亲和性相关,但在年长组群中则不相关。在NPY rs16147 T/T同卵双生者中,出生队列中的 "可接近性 "与平均值的偏差取决于5-羟色胺转运体启动子多态性:结论:NPY基因变异与反映社会宜人性的人格领域之间的关联在社会快速变化时会发生质的变化,这是可塑性基因与环境之间关系的一个例子。其潜在机制可能涉及血清素能系统的发展。
{"title":"Neuropeptide Y gene variants and Agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism.","authors":"Evelyn Kiive, Margus Kanarik, Toomas Veidebaum, Jaanus Harro","doi":"10.1017/neu.2023.23","DOIUrl":"10.1017/neu.2023.23","url":null,"abstract":"<p><strong>Objective: </strong>Neuropeptide Y (NPY) is a powerful regulator of anxious states, including social anxiety, but evidence from human genetic studies is limited. Associations of common gene variants with behaviour have been described as subject to birth cohort effects, especially if the behaviour is socially motivated. This study aimed to examine the association of <i>NPY</i> rs16147 and rs5574 with personality traits in highly representative samples of two birth cohorts of young adults, the samples having been formed during a period of rapid societal transition.</p><p><strong>Methods: </strong>Both birth cohorts (original <i>n</i> = 1238) of the Estonian Children Personality Behaviour and Health Study (ECPBHS) self-reported personality traits of the five-factor model at 25 years of age.</p><p><strong>Results: </strong>A significant interaction effect of the <i>NPY</i> rs16147 and rs5574 and birth cohort on Agreeableness was found. The T/T genotype of <i>NPY</i> rs16147 resulted in low Agreeableness in the older cohort (born 1983) and in high Agreeableness in the younger cohort (born 1989). The C/C genotype of <i>NPY</i> rs5574 was associated with higher Agreeableness in the younger but not in the older cohort. In the <i>NPY</i> rs16147 T/T homozygotes, the deviations from average in Agreeableness within the birth cohort were dependent on the serotonin transporter promoter polymorphism.</p><p><strong>Conclusions: </strong>The association between the <i>NPY</i> gene variants and a personality domain reflecting social desirability is subject to change qualitatively in times of rapid societal changes, serving as an example of the relationship between the plasticity genes and environment. The underlying mechanism may involve the development of the serotonergic system.</p>","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-8"},"PeriodicalIF":3.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9413239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes. 童年的不良经历和疾病的复发会影响肠道微生物组,从而影响自杀行为和重度抑郁症的表型:走向肠道表型。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2023-12-01 Epub Date: 2023-04-13 DOI: 10.1017/neu.2023.21
Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Kitiporn Plaimas, Apichat Suratanee, Sunchai Payungporn

The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared in 2008 (Maes et al., 2008). The purpose of the present study is to delineate a) the microbiome signature of the phenome of depression, including suicidal behaviours (SB) and cognitive deficits; the effects of adverse childhood experiences (ACEs) and recurrence of illness index (ROI) on the microbiome; and the microbiome signature of lowered high-density lipoprotein cholesterol (HDLc). We determined isometric log-ratio abundances or prevalences of gut microbiome phyla, genera, and species by analysing stool samples from 37 healthy Thai controls and 32 MDD patients using 16S rDNA sequencing. Six microbiome taxa accounted for 36% of the variance in the depression phenome, namely Hungatella and Fusicatenibacter (positive associations) and Butyricicoccus, Clostridium, Parabacteroides merdae, and Desulfovibrio piger (inverse association). This profile (labelled enterotype 1) indicates compositional dysbiosis, is strongly predicted by ACE and ROI, and is linked to SB. A second enterotype was developed that predicted a decrease in HDLc and an increase in the atherogenic index of plasma (Bifidobacterium, P. merdae, and Romboutsia were positively associated, while Proteobacteria and Clostridium sensu stricto were negatively associated). Together, enterotypes 1 and 2 explained 40.4% of the variance in the depression phenome, and enterotype 1 in conjunction with HDLc explained 39.9% of the variance in current SB. In conclusion, the microimmuneoxysome is a potential new drug target for the treatment of severe depression and SB and possibly for the prevention of future episodes.

2008 年发表的第一篇论文证明,重度抑郁症(MDD)与肠道微生物群的改变有关(Maes 等人,2008 年)。本研究的目的是确定 a) 抑郁症表型的微生物组特征,包括自杀行为(SB)和认知缺陷;不良童年经历(ACE)和疾病复发指数(ROI)对微生物组的影响;以及高密度脂蛋白胆固醇(HDLc)降低的微生物组特征。我们使用 16S rDNA 测序法分析了 37 名泰国健康对照者和 32 名 MDD 患者的粪便样本,从而确定了肠道微生物组各门、属和种的等比对数丰度或流行率。六个微生物群分类群占抑郁表型变异的 36%,即 Hungatella 和 Fusicatenibacter(正相关)以及 Butyricicoccus、Clostridium、Parabacteroides merdae 和 Desulfovibrio piger(反相关)。该特征(标为肠型 1)表明菌群组成失调,受 ACE 和 ROI 的强烈预测,并与 SB 有关。第二种肠型可预测高密度脂蛋白胆固醇(HDLc)的降低和血浆致动脉粥样硬化指数的升高(双歧杆菌、梅尔代梭菌和隆贝氏菌呈正相关,而变形杆菌和严格意义上的梭状芽孢杆菌呈负相关)。肠型 1 和 2 可共同解释抑郁表型中 40.4% 的变异,而肠型 1 与 HDLc 可共同解释当前 SB 中 39.9% 的变异。总之,微免疫氧体是治疗严重抑郁症和 SB 的潜在新药靶点,也可能是预防未来抑郁症发作的新药靶点。
{"title":"Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes.","authors":"Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Kitiporn Plaimas, Apichat Suratanee, Sunchai Payungporn","doi":"10.1017/neu.2023.21","DOIUrl":"10.1017/neu.2023.21","url":null,"abstract":"<p><p>The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared in 2008 (Maes <i>et al</i>., 2008). The purpose of the present study is to delineate a) the microbiome signature of the phenome of depression, including suicidal behaviours (SB) and cognitive deficits; the effects of adverse childhood experiences (ACEs) and recurrence of illness index (ROI) on the microbiome; and the microbiome signature of lowered high-density lipoprotein cholesterol (HDLc). We determined isometric log-ratio abundances or prevalences of gut microbiome phyla, genera, and species by analysing stool samples from 37 healthy Thai controls and 32 MDD patients using 16S rDNA sequencing. Six microbiome taxa accounted for 36% of the variance in the depression phenome, namely <i>Hungatella</i> and <i>Fusicatenibacter</i> (positive associations) and <i>Butyricicoccus, Clostridium, Parabacteroides merdae</i>, and <i>Desulfovibrio piger</i> (inverse association). This profile (labelled enterotype 1) indicates compositional dysbiosis, is strongly predicted by ACE and ROI, and is linked to SB. A second enterotype was developed that predicted a decrease in HDLc and an increase in the atherogenic index of plasma (<i>Bifidobacterium, P. merdae</i>, and <i>Romboutsi</i>a were positively associated, while <i>Proteobacteria</i> and <i>Clostridium sensu stricto</i> were negatively associated). Together, enterotypes 1 and 2 explained 40.4% of the variance in the depression phenome, and enterotype 1 in conjunction with HDLc explained 39.9% of the variance in current SB. In conclusion, the microimmuneoxysome is a potential new drug target for the treatment of severe depression and SB and possibly for the prevention of future episodes.</p>","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"328-345"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9356127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Time to transition from paediatric to adolescent bipolar disorder. 从儿童双相情感障碍过渡到青少年双相情感障碍的时间。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2023-12-01 Epub Date: 2023-05-16 DOI: 10.1017/neu.2023.26
Gin S Malhi, Maedeh Jadidi, Erica Bell
{"title":"Time to transition from paediatric to adolescent bipolar disorder.","authors":"Gin S Malhi, Maedeh Jadidi, Erica Bell","doi":"10.1017/neu.2023.26","DOIUrl":"10.1017/neu.2023.26","url":null,"abstract":"","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"372-373"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9551840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decreased beta 1 (12-15 Hertz) power modulates the transfer of suicidal ideation to suicide in major depressive disorder. 贝塔 1(12-15 赫兹)功率的降低会调节重度抑郁障碍患者自杀意念向自杀的转移。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2023-12-01 Epub Date: 2023-08-22 DOI: 10.1017/neu.2023.39
Chenguang Jiang, Zixuan Huang, Zhenhe Zhou, Limin Chen, Hongliang Zhou

Background: Suicide prevention for major depressive disorder (MDD) is a worldwide challenge, especially for suicide attempt (SA). Viewing suicide as a state rather than a lifetime event provided new perspectives on suicide research.

Objective: This study aimed to verify and complement SAs biomarkers of MDD with a recent SA sample.

Methods: This study included 189 participants (60 healthy controls; 47 MDD patients with non-suicide (MDD-NSs), 40 MDD patients with suicide ideation (MDD-SIs) and 42 MDD patients with SA (MDD-SAs)). MDD patients with an acute SA time was determined to be within 1 week since the last SA. SUICIDALITY Part in MINI was applied to evaluate suicidality. Absolute powers in 14 frequency bands were extracted from subject's resting-state electroencephalography data and compared within four groups. The relationship among suicidality, the number of SA and powers in significant frequency bands were investigated.

Results: MDD-SIs had increased powers in delta, theta, alpha and beta band on the right frontocentral channels compared to MDD-NSs, while MDD-SAs had decreased powers in delta, beta and gamma bands on widely the right frontocentral and parietooccipital channels compared to MDD-SIs. Beta 1 power was the lowest in MDD-SAs and was modulated by the number of SA. The correlation between suicidality and beta 1 power was negative in MDD-SAs and positive in MDD-SIs.

Conclusion: Reduced beta 1 (12-15 Hz) power could be essential in promoting suicidal behaviour in MDD. Research on recent SA samples contributes to a better understanding of suicide mechanisms and preventing suicidal behaviour in MDD.

背景:预防重度抑郁障碍(MDD)的自杀是一项世界性挑战,尤其是自杀未遂(SA)。将自杀视为一种状态而非终生事件为自杀研究提供了新的视角:本研究旨在通过最近的 SA 样本对 MDD 的 SA 生物标志物进行验证和补充:这项研究包括 189 名参与者(60 名健康对照组;47 名未自杀的 MDD 患者(MDD-NSs)、40 名有自杀意念的 MDD 患者(MDD-SIs)和 42 名有 SA 的 MDD 患者(MDD-SAs))。MDD 患者的急性 SA 时间被确定为自上次 SA 起的 1 周内。MINI 中的自杀倾向部分用于评估自杀倾向。从受试者的静息态脑电数据中提取 14 个频段的绝对功率,并在四个组内进行比较。研究了自杀倾向、SA数量和重要频段功率之间的关系:与 MDD-NSs 相比,MDD-SIs 增加了右侧额中央通道上 delta、theta、alpha 和 beta 频段的功率,而与 MDD-SIs 相比,MDD-SAs 减少了右侧额中央通道和顶枕叶通道上广泛的 delta、beta 和 gamma 频段的功率。MDD-SA 的 Beta 1 功率最低,并受 SA 数量的调节。在 MDD-SAs 中,自杀倾向与 beta 1 功率呈负相关,而在 MDD-SIs 中则呈正相关:结论:β1(12-15 Hz)功率降低可能是促进 MDD 自杀行为的关键因素。对近期 SA 样本的研究有助于更好地了解 MDD 的自杀机制和预防自杀行为。
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引用次数: 0
As a new challenger approaches, how will modern psychiatry cope with 'shifting realities'? 随着新挑战者的到来,现代精神病学将如何应对 "不断变化的现实"?
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2023-12-01 Epub Date: 2023-08-18 DOI: 10.1017/neu.2023.31
John O'Neill, Bahareh Nakisa, Harris Eyre, Ipsit V Vahia, Stephen M Schueller, Marina Tolou-Shams, Robert M Lundin
{"title":"As a new challenger approaches, how will modern psychiatry cope with 'shifting realities'?","authors":"John O'Neill, Bahareh Nakisa, Harris Eyre, Ipsit V Vahia, Stephen M Schueller, Marina Tolou-Shams, Robert M Lundin","doi":"10.1017/neu.2023.31","DOIUrl":"10.1017/neu.2023.31","url":null,"abstract":"","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"377-379"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10179155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Misconceptions about paediatric bipolar disorder. 对儿科双相情感障碍的误解。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2023-12-01 Epub Date: 2023-08-18 DOI: 10.1017/neu.2023.34
Michael H Connors
{"title":"Misconceptions about paediatric bipolar disorder.","authors":"Michael H Connors","doi":"10.1017/neu.2023.34","DOIUrl":"10.1017/neu.2023.34","url":null,"abstract":"","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"374-376"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Acta Neuropsychiatrica
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