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In Vivo Animal Model Evaluation of a Powerful Oral Nanomedicine for Treating Breast Cancer in BALB/c Mice Using 4T1 Cell Lines without Chemotherapy 一种口服纳米药物治疗BALB/c小鼠乳腺癌的体内动物模型评估,使用4T1细胞系,无需化疗
Pub Date : 2022-01-01 DOI: 10.4236/anp.2022.113006
Z. Fakhroueian, A. Massiha, Pegah Esmaeilzadeh, M. Assmar, A. Zahedi, Pouriya Esmaeilzadeh, Sara Rezaei, Shahab Rabiei Lalehdasht
Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic propos-als. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nanopolymer as co-assistants coordinating with efficacious suitable wetting agents, PEG-binding compound, and W/O emulsifier for producing eco-friendly wa-ter-based nanodrug. Several characterization techniques containing SEM, TEM, FTIR, photoluminescence, zeta potential, and UV-Vis absorption were employed for ZnO Q-Dot NPs in nanodrug. This work aims to investigate the anti-tumor effects of such nanomedicine on the 4T1 breast cancer cell line in BALB/c mice, being elaborated through intraperitoneal, injection (IVP) and oral therapy. The impressive findings showed that ZnO nanodrug caused changes in blood factors, having the most effectiveness at 40 µg/ml concentration after two weeks of oral treatments. The significant increase in white blood cells (WBC) neutrophils and meaningful decreases in lymphocytes and especially cholesterol were powerful simultaneous impacts, successfully treating malignant breast cancer masses. In this significant animal model research for breast cancer, the sick mice recovered entirely and even had a safe space to mate. Histopathological results showed no evidence of breast tumor formation or metastasis in the group treated with nanodrug and their children. This nanomedicine has a therapeutic effect, and is ready to be applied for treating volunteer breast cancer patients. However, its prevention (inhibitory) effect can also be analyzed and added to current data in future studies.
含有量子点纳米粒子(Q-Dot NPs)的纳米药物用于治疗严重的癌症,如乳腺癌,已经提出了奇妙的建议。在本研究中,ZnO量子点NPs通过ZnO@PVP纳米聚合物与高效的合适润湿剂、peg结合化合物和W/O乳化剂协同制备,制备出环保型水基纳米药物。采用SEM、TEM、FTIR、光致发光、zeta电位、UV-Vis吸收等表征技术对纳米药物中的ZnO Q-Dot NPs进行了表征。本研究旨在探讨该纳米药物对BALB/c小鼠4T1乳腺癌细胞系的抗肿瘤作用,并通过腹腔、注射(IVP)和口服治疗进行阐述。令人印象深刻的发现表明,ZnO纳米药物引起血液因子的变化,口服两周后,其浓度为40 μ g/ml时最有效。白细胞(WBC)中性粒细胞的显著增加和淋巴细胞(尤其是胆固醇)的显著减少是同时发生的强大影响,成功地治疗了恶性乳腺癌肿块。在这项重要的乳腺癌动物模型研究中,患病的老鼠完全康复,甚至有了安全的交配空间。组织病理学结果显示,在接受纳米药物治疗的组及其子女中,没有乳房肿瘤形成或转移的证据。这种纳米药物具有治疗效果,并准备用于治疗志愿者乳腺癌患者。但其预防(抑制)作用也可以在未来的研究中分析和补充到现有的数据中。
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引用次数: 0
Synthesis of Novel Virus-Like Mesoporous Silica-ZnO-Ag Nanoparticles and Quercetin Synergize with NIR Laser for Omicron Mutated Covid-19 Virus Infectious Diseases Treatment 新型病毒样介孔二氧化硅- zno - ag纳米颗粒的合成与槲皮素与近红外激光协同治疗组微米突变的Covid-19病毒传染病
Pub Date : 2022-01-01 DOI: 10.4236/anp.2022.111002
Fadilah Ibrahim
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引用次数: 2
Synthesis and Stability Studies of 225Actinium Tin Colloid Radiopharmaceutical 225锕-锡胶体放射性药物的合成及稳定性研究
Pub Date : 2022-01-01 DOI: 10.4236/anp.2022.111003
Davut Cakici, B. Kilbas
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引用次数: 1
Bio-Fabrication of Silver Nanoparticles Using Catha edulis Extract: Procedure Optimization and Antimicrobial Efficacy Encountering Antibiotic-Resistant Pathogens 利用羽衣甘蓝提取物制备纳米银:工艺优化及耐药病原菌的抗菌效果
Pub Date : 2022-01-01 DOI: 10.4236/anp.2022.112004
A. Numan, Mashhour Ahmed, M. S. A. Galil, Mohyeddine Al-qubati, A. Raweh, E. Helmi
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引用次数: 4
Removal of Fluoride from Water Using Mesoporous MCM-41: An Optimization Approach Using Response Surface Methodology (RSM) 响应面法优化介孔MCM-41去除水中氟化物的研究
Pub Date : 2021-08-03 DOI: 10.4236/anp.2021.103007
Bodhaditya Das, Saumen Banerjee, P. Raul, R. R. Devi, I. M. Umlong, A. K. Talukdar, Sanjai K. Dwivedi
Fluoride above 1.5 mg·L-1 is injurious to health. Removal of fluoride from water using mesoporous MCM-41 as a strong adsorbent material has been attempted. Characterization using transmission electron microscopic study of calcined MCM-41 showed the regular hexagonal array of mesoporous channels with an average size of 20 nm and the surface area (BET study) of 1306.96 m2·g-1. The average pore size of the particles was found to be 14.21 nm. A study on the effect of contact time on the removal of fluoride revealed that more than 85% uptake of fluoride onto MCM-41 was achieved at a contact time of 120 min. From the Langmuir adsorption study, the maximum sorption capacity of fluoride was found to be 63.05 mg/g at 301 K. From the thermodynamic study, the +ΔHo value of 2.29 kJ·mol-1 indicated the endothermic nature of the removal process. Application of Response Surface Model suggested that 77.88% of fluoride removal can be achieved at fluoride concentration of 10 mg·L-1, pH (6.3), and contact time of 120 min.
超过1.5 mg·L-1的氟化物对健康有害。已尝试使用介孔MCM-41作为强吸附剂从水中去除氟化物。通过透射电镜对煅烧后的MCM-41进行表征,发现其平均尺寸为20 nm,比表面积(BET研究)为1306.96 m2·g-1的正六边形介孔通道阵列。颗粒的平均孔径为14.21 nm。接触时间对氟去除率影响的研究表明,在接触时间为120 min时,MCM-41对氟的吸收率超过85%。Langmuir吸附研究发现,在301 K下,氟的最大吸附量为63.05 mg/g。从热力学研究来看,+ΔHo值为2.29 kJ·mol-1,表明脱除过程是吸热的。响应面模型的应用表明,当氟浓度为10 mg·L-1、pH为6.3、接触时间为120 min时,除氟率可达77.88%。
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引用次数: 3
Synthesis and Application of Nanocomposite Reinforced with Decorated Multi Walled Carbon Nanotube with Luminescence Quantum Dots 发光量子点修饰多壁碳纳米管增强纳米复合材料的合成与应用
Pub Date : 2021-04-30 DOI: 10.4236/ANP.2021.102006
J. A. Dalaeen, Yashfeen Khan, Anees Ahmad
Amidst the COVID-19 pandemic, environmental problems such as energy crisis, global warming, and contamination from pathogenic micro-organisms are still prevailed and strongly demanded progress in high-performance energy storing and anti-microbial materials. The nanocomposites are materials that have earned large interest owing to their promising applications for countering global issues related to sustainable energy and a flourishing environment. Here, polypyrrole coated hybrid nanocomposites of multi-walled carbon nanotube and cadmium sulfide quantum dots named MCP were synthesized using facile and low-cost in-situ oxidative polymerization method. Characterization techniques confirmed the synthesis. Electrochemical studies showed that the nanocomposite 1-MCP showed an impressively higher super capacitance behavior in comparison to f-MWCNT, 7-MCP and 5-MCP. The improved performance of the nanocomposites was attributed mainly to the good conductivity of carbon nanotubes and polypyrrole, high surface area, and stability of the carbon nanotubes and the high electrocatalytic activity of the cadmium sulfide quantum dots. Owing to the synergistic effect of MWCNT, CdS, and PPy the synthesized ternary nanocomposite also inhibited the growth and multiplication of tested bacteria such as S. aureus, and E. coli completely within 24 h. On the whole, the assimilated nanocomposite MCP opens promising aspects for the development of upcoming energy storage devices and as an antibacterial agent.
在新冠肺炎大流行期间,能源危机、全球变暖和病原微生物污染等环境问题仍然普遍存在,并强烈要求在高性能储能和抗菌材料方面取得进展。纳米复合材料因其在应对与可持续能源和繁荣环境相关的全球问题方面的良好应用而引起了人们的极大兴趣。采用简单、低成本的原位氧化聚合方法,合成了聚吡咯包覆的多壁碳纳米管和硫化镉量子点杂化纳米复合材料MCP。表征技术证实了该合成。电化学研究表明,与f-MWCNT、7-MCP和5-MCP相比,纳米复合材料1-MCP表现出令人印象深刻的更高的超电容行为。纳米复合材料性能的提高主要归因于碳纳米管和聚吡咯的良好导电性、碳纳米管的高表面积和稳定性以及硫化镉量子点的高电催化活性。由于MWCNT、CdS和PPy的协同作用,合成的三元纳米复合材料也在24小时内完全抑制了测试细菌(如金黄色葡萄球菌和大肠杆菌)的生长和增殖。总的来说,同化的纳米复合材料MCP为开发即将到来的储能器件和作为抗菌剂开辟了有前景的方面。
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引用次数: 0
Pattern of Growth and Dry Matter Accumulation in Some Improved Cowpea Varieties (Vigna unguiculata) Exposed to Alpha Nano Spin α纳米自旋对改良豇豆品种生长和干物质积累的影响
Pub Date : 2021-04-30 DOI: 10.4236/ANP.2021.102004
H. Kana, Emmanuel Enock Goler, Peter Barka Mshemlbula
Ten (10) cowpea varieties exposed to alpha nano spin were evaluated during the 2019 cropping season to access the role of alpha nano spin in their growth and dry matter accumulation at the Botanical garden of Federal University, Lafia. A Randomized Complete Block Design (RCBD) with four replications was used. The fourth replication was used for the destructive sampling over time. The seed was exposed to alpha nano spin before planting at 0, 20, 40 and 60 minutes respectively. Results of the study showed that the varieties differed significantly with respect to morphological traits studied (P s such as vine length, number of leaves and above ground stems were significantly influenced by alpha nano spin bombardment. 40 mins alpha nano spin resulted in maximum accumulation of dry matter, leaf area and leaf area index. The traits evaluated were stable under alpha nano spin exposure, suggesting that they could be useful indices in creating genetic variability in each of the varieties.
在拉菲亚联邦大学植物园,对2019年种植季节暴露于α-纳米自旋的十(10)个豇豆品种进行了评估,以了解α-纳米旋转在其生长和干物质积累中的作用。采用四个重复的随机完全块设计(RCBD)。第四次复制用于随时间的破坏性采样。种子在种植前分别在0、20、40和60分钟暴露于α-纳米自旋。研究结果表明,这些品种在所研究的形态特征方面存在显著差异(葡萄藤长度、叶片数量和地上茎等P s受到α-纳米自旋轰击的显著影响。40分钟的α-纳米旋转导致干物质、叶面积和叶面积指数的最大积累。在α-纳米旋暴露下,所评估的性状是稳定的,这表明它们可能是在每个品种中产生遗传变异的有用指标。)。
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引用次数: 0
Pure SnO2 Gas Sensor with High Sensitivity and Selectivity towards C2H5OH 对C2H5OH具有高灵敏度和选择性的纯SnO2气体传感器
Pub Date : 2021-01-01 DOI: 10.4236/ANP.2021.102005
Abeer A. Alhadi, Shuyi Ma, Ting-ting Yang, S. Pei, P. Yun, Khalid Ahmed Abbakar, Qianqian Zhang, N. Ma, Manahil H. Balal, Hamouda Adam Hamouda, K. M. Adam
To observation, poisonous gases in the environment, Sensors with high selectivity, high response and low operating temperature are required. In this work, pure SnO2 nanoparticles was prepared by using a simple and inexpensive technique (hydrothermal method) without a template. Various confirmatory tests were performed to characterize SnO2 nanoparticles such as energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Transition Electron Microscopy (TEM), during the detection of the gas, we found that pure SnO2 nanoparticles has a high selectivity for ethanol to 100 ppm at a low temperature (180°C) and a high response (about 27 s) and a low detection limit of 5 ppm, also it have response/recovery times about (4 s, 2 s) respectively. The distinctive sensing properties of SnO2 sensor make it a promising candidate for ethanol detection. Furthermore, the gas-sensing mechanism have been examined.
为了观察环境中的有毒气体,需要具有高选择性、高响应和低工作温度的传感器。在这项工作中,使用简单而廉价的技术(水热法)制备了纯净的SnO2纳米颗粒,而无需模板。通过能量色散x射线能谱(EDX)、x射线衍射(XRD)、扫描电镜(SEM)和透射电镜(TEM)等验证性测试对SnO2纳米粒子进行了表征。在气体检测过程中,我们发现纯SnO2纳米粒子在低温(180℃)下对100 ppm乙醇具有高选择性,高响应(约27 s),低检测限为5 ppm,响应/恢复时间约为(4 s)。2 s)。SnO2传感器独特的传感特性使其成为乙醇检测的理想选择。此外,还对气敏机理进行了研究。
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引用次数: 4
A Brief Review of How to Construct an Enzyme-Based H2O2 Sensor Involved in Nanomaterials 纳米材料酶基H2O2传感器的研究进展
Pub Date : 2021-01-01 DOI: 10.4236/anp.2021.101001
U. Nestor, Hitimana Frodouard, Muhizi Theoneste
This article briefly reviews how to construct an enzyme based hydrogen peroxide sensor involving nanomaterials, which has the advantages of high efficiency, good sensitivity and selectivity, fast response time and an extended range of linearity with lower detection limit. Glucose biosensor is constructed by immobilizing glucose oxidase enzyme on the polycarbonate membrane and the protective cover is then filled with a physiological phosphate buffer, pH 7.4. The novel blocking hydrophobic membrane which is only permeable to hydrogen peroxide is used to eliminate electrochemical interferences. This constructed enzyme based H2O2 biosensor is miniaturized by the involvement of nanomaterials like carbon nanotubes, platinum nanoparticles and silver nanoparticles and it can achieve the effective microscopic detection of glucose. The introduction of nanomaterials including some pure metals (Ag, Au, Pd, Ni, Pt, and Cu), metal oxide (ZnO and TiO2), bimetallic (Au/Ag and Au/Pt) and carbon (nanotubes and graphene) nanomaterials in the construction of the enzyme based H2O2 biosensor improves its sensitivity and performance by enhancing the enzymatic activity, and allows the introduction of many new signal transduction technologies in biosensors. This review article summarizes the working principles of glucose oxidase based hydrogen peroxide sensor, importance of involving nanomaterials in biosensor manufacturing, basic characteristics and components of a biosensor, generations glucose biosensors, procedure of making hydrogen peroxide based biosensor, synthesis of nanomaterials involved in hydrogen peroxide biosensor, and finally some examples of nanomaterials which intervene in hydrogen peroxide biosensor.
本文综述了利用纳米材料构建酶基过氧化氢传感器的方法,该传感器具有效率高、灵敏度和选择性好、响应时间快、线性范围广、检出限低等优点。葡萄糖生物传感器是通过将葡萄糖氧化酶固定在聚碳酸酯膜上,然后在保护膜上填充pH为7.4的生理磷酸盐缓冲液来构建的。采用仅对过氧化氢渗透的新型阻水疏水膜来消除电化学干扰。本文构建的酶基H2O2生物传感器通过碳纳米管、铂纳米粒子、银纳米粒子等纳米材料的参与实现了微型化,实现了葡萄糖的有效显微检测。在构建酶基H2O2生物传感器的过程中,引入了纯金属(Ag、Au、Pd、Ni、Pt和Cu)、金属氧化物(ZnO和TiO2)、双金属(Au/Ag和Au/Pt)和碳(纳米管和石墨烯)纳米材料,提高了酶活性,提高了传感器的灵敏度和性能,并为生物传感器引入了许多新的信号转导技术。本文综述了基于葡萄糖氧化酶的过氧化氢传感器的工作原理、纳米材料在生物传感器制造中的重要性、生物传感器的基本特性和组成、葡萄糖生物传感器的种类、基于过氧化氢的生物传感器的制备过程、过氧化氢生物传感器中纳米材料的合成以及纳米材料介入过氧化氢生物传感器的一些实例。
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引用次数: 7
Structural and Elastic Behavior of Chromium Doped Pr0.5Sr0.5MnO3 System 铬掺杂Pr0.5Sr0.5MnO3体系的结构和弹性行为
Pub Date : 2021-01-01 DOI: 10.4236/ANP.2021.101002
Ashok Kumar Kusuma, E. Sagar, G. S. Reddy, K. Kumar
A series of colossal magneto resistance (CMR) materials with compositional formula Pr0.5Sr0.5Mn1-xCrxO3 (x = 0, 0.1, 0.2, 0.3, 0.4) were prepared by sol-gel technique using pure metal nitrates as the starting materials. These samples were characterized structurally by X-ray diffraction, FTIR and SEM. All the samples exhibit orthorhombic structure without any detectable impurities. The bulk densities for all the compositions were measured from the pellets. The Young’s and Rigidity moduli, Poisson’s ratio and Debye temperature of all the compositions were calculated with the experimentally measured ultrasonic longitudinal and shear velocities at room temperature using pulse transmission technique. As the materials are porous, zero porous elastic moduli have also been calculated using a well-known Hasselmann and Fulrath model. The observed variation of elastic moduli with varying chromium doping concentration has been studied qualitatively.
以纯金属硝酸盐为原料,采用溶胶-凝胶法制备了一系列组成公式为Pr0.5Sr0.5Mn1-xCrxO3 (x = 0,0.1, 0.2, 0.3, 0.4)的巨型磁阻(CMR)材料。采用x射线衍射、红外光谱和扫描电镜对样品进行了结构表征。所有样品均呈正交结构,无任何可检测到的杂质。从颗粒中测量了所有成分的堆积密度。利用脉冲传输技术在室温下实测的超声纵、剪切速度,计算了各组分的杨氏模量、刚度模量、泊松比和德拜温度。由于材料是多孔的,零多孔弹性模量也用著名的Hasselmann和Fulrath模型计算。对观察到的弹性模量随铬掺杂浓度的变化进行了定性研究。
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引用次数: 0
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