Introduction/Aim. Patient falls in hospital conditions are among the most common serious adverse events following a cerebrovascular insult at all stages of the disease. The aim of this study was to investigate the risk of falls in patients with cerebrovascular disease. Methods. A clinical case-control observational study was conducted in this investigation. The sample consisted of patients who suffered from cerebrovascular diseases and were admitted to the Special Hospital for Cerebrovascular Diseases "Sveti Sava" in Belgrade, in the period from February 3, 2018, to June 28, 2019. The Morse questionnaire was used to assess a fall risk. All statistical calculations were performed using the standard commercial software package SPSS, version 21.0. Results. Most of the subjects with a cerebrovascular insult (505 (90.0%)) had a high risk of falls, i.e. they had the Morse score values ≥ 45. The mean Morse score of the subjects in the study was 67.07 ± 21.08. The risk of falling, according to the Morse score, is the highest among subjects diagnosed with bleeding (95.7%: 96.7%) and left-sided neurological deficit (91.7%:90.8%) in both examined groups. Conclusion. It is of great importance to organizing training programs for patients, healthcare providers, and medical staff to prevent falls in hospital conditions.
{"title":"The risk of falls in patients with cerebrovascular disease","authors":"Aleksandar Nenadović, Olivera Đurović, Snezana Stanković, Biljana Georgievski-Brkić, Milica Milivojević, Marjana Vukičević, Svetlana Radević, Snežana Radovanović","doi":"10.5937/afmnai40-41745","DOIUrl":"https://doi.org/10.5937/afmnai40-41745","url":null,"abstract":"Introduction/Aim. Patient falls in hospital conditions are among the most common serious adverse events following a cerebrovascular insult at all stages of the disease. The aim of this study was to investigate the risk of falls in patients with cerebrovascular disease. Methods. A clinical case-control observational study was conducted in this investigation. The sample consisted of patients who suffered from cerebrovascular diseases and were admitted to the Special Hospital for Cerebrovascular Diseases \"Sveti Sava\" in Belgrade, in the period from February 3, 2018, to June 28, 2019. The Morse questionnaire was used to assess a fall risk. All statistical calculations were performed using the standard commercial software package SPSS, version 21.0. Results. Most of the subjects with a cerebrovascular insult (505 (90.0%)) had a high risk of falls, i.e. they had the Morse score values ≥ 45. The mean Morse score of the subjects in the study was 67.07 ± 21.08. The risk of falling, according to the Morse score, is the highest among subjects diagnosed with bleeding (95.7%: 96.7%) and left-sided neurological deficit (91.7%:90.8%) in both examined groups. Conclusion. It is of great importance to organizing training programs for patients, healthcare providers, and medical staff to prevent falls in hospital conditions.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladana Stojiljković, Nikola Stefanović, Marija Vukelić-Nikolić, Branka Đorđević, Jelena Bašić, Gordana Kocić, Tatjana Cvetković
Introduction. Standard biomarkers for the diagnosis and follow-up of chronic kidney disease patients are appropriate neither in early diagnostics, adequate follow-up and progression assessment nor in complication development risk assessment. For that reason, a search for new, more suitable biomarkers continues. Various studies suggested microRNAs as a potential solution, as they are involved in the pathogenesis of diabetic nephropathy, kidney cancer and kidney function impairment in general. Methods. Internet search engines were used to find and select relevant literature data and electronic databases. Results. Research published so far, in oncology especially, have reported various single microRNAs and panels of microRNAs as candidates for routine diagnostic implementation. Chronic kidney disease is, however, quite complex in terms of etiology of the disease occurrence, since there are many causes that can lead to kidney tissue damage and impairment of its function and finally full development of the chronic kidney disease. MicroRNAs are stable in bodily fluids, and hemodialysis procedure does not affect their levels. Also, high RNase activity in chronic kidney disease patients does not accelerate microRNA degradation in their samples. Conclusions. Literature data suggest that microRNAs are appropriate candidates for diagnostic use in chronic kidney disease. However, there are challenges that are yet to be overcome in order to use microRNAs routinely.
{"title":"MicroRNA: Potential biomarkers in chronic kidney disease","authors":"Vladana Stojiljković, Nikola Stefanović, Marija Vukelić-Nikolić, Branka Đorđević, Jelena Bašić, Gordana Kocić, Tatjana Cvetković","doi":"10.5937/afmnai40-39805","DOIUrl":"https://doi.org/10.5937/afmnai40-39805","url":null,"abstract":"Introduction. Standard biomarkers for the diagnosis and follow-up of chronic kidney disease patients are appropriate neither in early diagnostics, adequate follow-up and progression assessment nor in complication development risk assessment. For that reason, a search for new, more suitable biomarkers continues. Various studies suggested microRNAs as a potential solution, as they are involved in the pathogenesis of diabetic nephropathy, kidney cancer and kidney function impairment in general. Methods. Internet search engines were used to find and select relevant literature data and electronic databases. Results. Research published so far, in oncology especially, have reported various single microRNAs and panels of microRNAs as candidates for routine diagnostic implementation. Chronic kidney disease is, however, quite complex in terms of etiology of the disease occurrence, since there are many causes that can lead to kidney tissue damage and impairment of its function and finally full development of the chronic kidney disease. MicroRNAs are stable in bodily fluids, and hemodialysis procedure does not affect their levels. Also, high RNase activity in chronic kidney disease patients does not accelerate microRNA degradation in their samples. Conclusions. Literature data suggest that microRNAs are appropriate candidates for diagnostic use in chronic kidney disease. However, there are challenges that are yet to be overcome in order to use microRNAs routinely.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135610800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovana Cvetković, Sonja Stojanović, Ivan Tasić, Bojana Stamenković, Jovan Nedović, Sanja Stojanović
Aim. The aim of the paper was to examine the impact of disease duration and administered therapy on the development of metabolic syndrome (MetS) in patients with systemic lupus erythematosus (SLE). Material and methods. This study involved 55 patients (50 females and 5 males) with the diagnosis and 49 healthy controls of similar age. MetS was defined according to modified NCEP-ATP III diagnostic criteria, and obesity was defined by body mass index BMI > 30. Results. In the group of SLE patients with MetS, there were 23 individuals (41.82%). In the control group, there were 10 (20.4%) patients with MetS. There were significantly more SLE patients with MetS in comparison to the controls (p = 0.04). Duration of the disease in the group with MetS was longer in comparison to those without MetS, but it was not statistically significant (15.35 ± 10.26 vs 10.44 ± 7.88, p = 0.073). The study confirmed that there is a moderate association (CC = 0.355) between disease duration and number of MetS parameters, however, this dependency was not statistically significant (p = 0.439). In the group without MetS, there were statistically more patients treated with antimalarial drugs monotherapy (p = 0.023). It has been found that the patients with MetS were treated with corticosteroid therapy longer than those without MetS, but it was not statistically significant (153.57 ± 103.34 vs 114.75 ± 83.32, p = 0.129). Conclusion. Patients with longer SLE duration have more often MetS. It has been shown that, statistically, more patients without MetS were treated with antimalarial drugs monotherapy, and that long-term CS use, in our study, was not associated with higher incidence of MetS.
的目标。本文的目的是研究疾病持续时间和给药治疗对系统性红斑狼疮(SLE)患者代谢综合征(MetS)发展的影响。材料和方法。本研究纳入55例确诊患者(50例女性，5例男性)和49例年龄相仿的健康对照。根据修改后的NCEP-ATP III诊断标准定义MetS，根据体重指数BMI >定义肥胖;30.结果。合并MetS的SLE患者组有23例(41.82%)。在对照组中，有10例(20.4%)患者发生MetS。与对照组相比，合并met的SLE患者明显更多(p = 0.04)。有MetS组病程较无MetS组长，但差异无统计学意义(15.35±10.26 vs 10.44±7.88,p = 0.073)。研究证实，病程与MetS参数数量之间存在中度相关性(CC = 0.355)，但这种相关性无统计学意义(p = 0.439)。在没有MetS的组中，使用抗疟药物单一治疗的患者有统计学意义(p = 0.023)。研究发现，有MetS的患者比无MetS的患者接受皮质类固醇治疗的时间更长，但差异无统计学意义(153.57±103.34 vs 114.75±83.32,p = 0.129)。结论。SLE病程较长的患者有较多的MetS。从统计上看，更多未患MetS的患者接受抗疟药物单药治疗，而在我们的研究中，长期使用抗疟药物与较高的MetS发生率无关。
{"title":"Association of the disease duration and administered therapy with metabolic syndrome in patients with systemic lupus erythematosus","authors":"Jovana Cvetković, Sonja Stojanović, Ivan Tasić, Bojana Stamenković, Jovan Nedović, Sanja Stojanović","doi":"10.5937/afmnai40-40813","DOIUrl":"https://doi.org/10.5937/afmnai40-40813","url":null,"abstract":"Aim. The aim of the paper was to examine the impact of disease duration and administered therapy on the development of metabolic syndrome (MetS) in patients with systemic lupus erythematosus (SLE). Material and methods. This study involved 55 patients (50 females and 5 males) with the diagnosis and 49 healthy controls of similar age. MetS was defined according to modified NCEP-ATP III diagnostic criteria, and obesity was defined by body mass index BMI > 30. Results. In the group of SLE patients with MetS, there were 23 individuals (41.82%). In the control group, there were 10 (20.4%) patients with MetS. There were significantly more SLE patients with MetS in comparison to the controls (p = 0.04). Duration of the disease in the group with MetS was longer in comparison to those without MetS, but it was not statistically significant (15.35 ± 10.26 vs 10.44 ± 7.88, p = 0.073). The study confirmed that there is a moderate association (CC = 0.355) between disease duration and number of MetS parameters, however, this dependency was not statistically significant (p = 0.439). In the group without MetS, there were statistically more patients treated with antimalarial drugs monotherapy (p = 0.023). It has been found that the patients with MetS were treated with corticosteroid therapy longer than those without MetS, but it was not statistically significant (153.57 ± 103.34 vs 114.75 ± 83.32, p = 0.129). Conclusion. Patients with longer SLE duration have more often MetS. It has been shown that, statistically, more patients without MetS were treated with antimalarial drugs monotherapy, and that long-term CS use, in our study, was not associated with higher incidence of MetS.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. The incidence of liver cancer is increasing globally. Fatty acids in lipid metabolism are associated with cancer risk by maintaining cancer cell membrane structure and transducing cancer signaling, and their increased synthesis promotes tumor growth, angiogenesis, and tumor metastasis. Methods. After identification of the ELOVL3 gene involved in fatty acid metabolism, which is related to the prognosis of liver cancer, its expression level was extracted from The Cancer Genome Atlas (TCGA) database, and differential analysis, survival analysis, clinical correlation analysis and nomogram were used to predict the survival rate. A comprehensive meta-analysis was performed to further evaluate the prognostic value of ELOVL3. Finally, enrichment analysis and immune analysis were performed on the high and low expression groups of ELOVL3 gene to explore the value of ELOVL3 in predicting the prognosis and immunotherapy of liver cancer patients. Results. Patients with high ELOVL3 expression had poor overall survival and progression-free survival. The nomogram and the area under the ROC curve also indicated that the expression of ELOVL3 gene had high accuracy in predicting the survival time of liver cancer patients. The expression of ELOVL3 was significantly different in the early stage of tumor grade, tumor stage and T stage. Enrichment analysis and immunological analysis revealed a variety of information. The immunotherapy analysis also showed that low ELOVL3 was more effective than high ELOVL3 when receiving immunotherapy. Conclusion. The expression of ELOVL3 gene is significantly elevated in HCC and is associated with cancer development and poor prognosis.
介绍。肝癌的发病率在全球范围内呈上升趋势。脂质代谢中的脂肪酸通过维持肿瘤细胞膜结构和传导癌症信号与癌症风险相关，其合成增加促进肿瘤生长、血管生成和肿瘤转移。方法。在鉴定出与肝癌预后相关的参与脂肪酸代谢的ELOVL3基因后，从the cancer Genome Atlas (TCGA)数据库中提取其表达水平，采用差异分析、生存分析、临床相关分析和nomogram预测生存率。采用综合meta分析进一步评价ELOVL3的预后价值。最后对ELOVL3基因高表达组和低表达组进行富集分析和免疫分析，探讨ELOVL3基因在预测肝癌患者预后和免疫治疗中的价值。结果。ELOVL3高表达的患者总生存期和无进展生存期较差。nomogram和ROC曲线下面积也显示ELOVL3基因的表达对肝癌患者生存时间的预测具有较高的准确性。ELOVL3的表达在肿瘤分级、肿瘤分期和T期的早期有显著差异。富集分析和免疫学分析揭示了多种信息。免疫治疗分析也显示，在接受免疫治疗时，低ELOVL3比高ELOVL3更有效。结论。ELOVL3基因在HCC中的表达显著升高，与肿瘤发展和不良预后相关。
{"title":"Identification of ELOVL3 as a novel prognostic marker for liver cancer","authors":"Yiyang Chen, Wanbang Zhou, Yiju Gon, Xi Ou","doi":"10.5937/afmnai40-40853","DOIUrl":"https://doi.org/10.5937/afmnai40-40853","url":null,"abstract":"Introduction. The incidence of liver cancer is increasing globally. Fatty acids in lipid metabolism are associated with cancer risk by maintaining cancer cell membrane structure and transducing cancer signaling, and their increased synthesis promotes tumor growth, angiogenesis, and tumor metastasis. Methods. After identification of the ELOVL3 gene involved in fatty acid metabolism, which is related to the prognosis of liver cancer, its expression level was extracted from The Cancer Genome Atlas (TCGA) database, and differential analysis, survival analysis, clinical correlation analysis and nomogram were used to predict the survival rate. A comprehensive meta-analysis was performed to further evaluate the prognostic value of ELOVL3. Finally, enrichment analysis and immune analysis were performed on the high and low expression groups of ELOVL3 gene to explore the value of ELOVL3 in predicting the prognosis and immunotherapy of liver cancer patients. Results. Patients with high ELOVL3 expression had poor overall survival and progression-free survival. The nomogram and the area under the ROC curve also indicated that the expression of ELOVL3 gene had high accuracy in predicting the survival time of liver cancer patients. The expression of ELOVL3 was significantly different in the early stage of tumor grade, tumor stage and T stage. Enrichment analysis and immunological analysis revealed a variety of information. The immunotherapy analysis also showed that low ELOVL3 was more effective than high ELOVL3 when receiving immunotherapy. Conclusion. The expression of ELOVL3 gene is significantly elevated in HCC and is associated with cancer development and poor prognosis.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mladen Kasalović, Gojko Igrutinović, Zlatan Elek, Aleksandar Jakovljević, Nikola Miljković, Milica Milentijević
Background. Necrotizing soft tissue infections are actually the diseases with a severe outcome characterized by the progression of soft tissue inflammation with a catastrophic prognosis and the risk of major functional consequences. Only prompt diagnosis and prompt care, including prompt administration of appropriate antibiotic therapy and surgical treatment, can improve the outcome. Case report. A female patient, aged 66 years, came due to swelling and pain in the perineum. Before admission, the pains were of low intensity, and immediately before admission, their intensity increased. An incision was made in the perineal region and the abdominal region on the left. During the preparation, we came across a necrotic tissue from which a dark-gray liquid flew that had a strong smell. From the tenth postoperative day, secondary sutures were partly placed. Conclusion. Mortality and morbidity in this disease are high. A potential new treatment for this disease may be an antigen-inhibiting vaccine.
{"title":"Necrotizing fascitis: A case report","authors":"Mladen Kasalović, Gojko Igrutinović, Zlatan Elek, Aleksandar Jakovljević, Nikola Miljković, Milica Milentijević","doi":"10.5937/afmnai40-39840","DOIUrl":"https://doi.org/10.5937/afmnai40-39840","url":null,"abstract":"Background. Necrotizing soft tissue infections are actually the diseases with a severe outcome characterized by the progression of soft tissue inflammation with a catastrophic prognosis and the risk of major functional consequences. Only prompt diagnosis and prompt care, including prompt administration of appropriate antibiotic therapy and surgical treatment, can improve the outcome. Case report. A female patient, aged 66 years, came due to swelling and pain in the perineum. Before admission, the pains were of low intensity, and immediately before admission, their intensity increased. An incision was made in the perineal region and the abdominal region on the left. During the preparation, we came across a necrotic tissue from which a dark-gray liquid flew that had a strong smell. From the tenth postoperative day, secondary sutures were partly placed. Conclusion. Mortality and morbidity in this disease are high. A potential new treatment for this disease may be an antigen-inhibiting vaccine.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Cardiac metastasis of uterine cervical cancer diagnosed prior to mortality (antemortem) is extremely rare. Case report. A female patient 49 years old was brought to the Emergency Department of the Institute for Treatment and Rehabilitation Niška Banja in cardiac arrest, without a pulse and blood pressure. An electrocardiogram revealed sustained ventricular tachycardia, which was terminated by two DC shocks (100J + 150J). Anamnesis and medical history revealed that she had had her squamous cell carcinoma of the uterine cervix removed and had subsequently received seven out of ten planned cycles of chemotherapy and twenty-eight cycles of radiotherapy. The patient was then transferred to the Coronary Unit, where cardiac ultrasound was performed. A homogenous mass measuring 31 x 50 mm was found in the right ventricle. In view of this, cardiac magnetic resonance imaging was performed. This confirmed the presence of the tumor mass in the right ventricle. Unfortunately, only a month after being discharged from our Institute, the patient was admitted to the Clinic of Neurology due to a loss of consciousness. Computer tomography of endocranium was performed revealing metastatic brain lesions. The patient succumbed to the disease just a couple of months later. Conclusion. We presented a rare case of antemortem diagnosed right ventricle metastases in a patient with uterine cervical cancer. Setting the diagnosis in these patients is a challenge in everyday clinical practice since metastases can produce the clinical picture that masks the real etymology of uterine cervical cancer.
{"title":"Right ventricular metastasis of uterine cervical cancer: A case report","authors":"Milovan Stojanović, Bojan Ilić, Dragan Marinković, Sandra Šarić, Dejan Hristov, Marina Deljanin-Ilić","doi":"10.5937/afmnai40-39597","DOIUrl":"https://doi.org/10.5937/afmnai40-39597","url":null,"abstract":"Introduction. Cardiac metastasis of uterine cervical cancer diagnosed prior to mortality (antemortem) is extremely rare. Case report. A female patient 49 years old was brought to the Emergency Department of the Institute for Treatment and Rehabilitation Niška Banja in cardiac arrest, without a pulse and blood pressure. An electrocardiogram revealed sustained ventricular tachycardia, which was terminated by two DC shocks (100J + 150J). Anamnesis and medical history revealed that she had had her squamous cell carcinoma of the uterine cervix removed and had subsequently received seven out of ten planned cycles of chemotherapy and twenty-eight cycles of radiotherapy. The patient was then transferred to the Coronary Unit, where cardiac ultrasound was performed. A homogenous mass measuring 31 x 50 mm was found in the right ventricle. In view of this, cardiac magnetic resonance imaging was performed. This confirmed the presence of the tumor mass in the right ventricle. Unfortunately, only a month after being discharged from our Institute, the patient was admitted to the Clinic of Neurology due to a loss of consciousness. Computer tomography of endocranium was performed revealing metastatic brain lesions. The patient succumbed to the disease just a couple of months later. Conclusion. We presented a rare case of antemortem diagnosed right ventricle metastases in a patient with uterine cervical cancer. Setting the diagnosis in these patients is a challenge in everyday clinical practice since metastases can produce the clinical picture that masks the real etymology of uterine cervical cancer.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Živković, L. Dimitrijević, H. Čolović, D. Zlatanovic, M. Spalević, N. Savić
Introduction. Aesthetic appearance is one of the major concerns in adolescent idiopathic scoliosis (AIS) patients and its improvement is one of the main treatment's goals. Poor trunk appearance is associated with reduced quality of life in adolescents with idiopathic scoliosis. Aim. To review instruments that have been created to evaluate poor trunk appearance in these children. Material and methods. PubMed database and the Consortium of Libraries of Serbia for Unified Acquisition - KoBSON were searched using the keywords "adolescent scoliosis", "aesthetic appearance", "evaluation" and "questionnaires". Results. In order to evaluate the aesthetic impairment in these patients, various instruments have been created. They can roughly be classed as instruments that assess subjective perception or objective aesthetic appearance. The first group consists primarily of self-administered quality of life questionnaires that include an aesthetic component, such as the Scoliosis Research Society 22 (SRS-22) questionnaire and the Italian Spinal Youth Quality of Life (ISYQoL) questionnaire, as well as visual scales based on patient-completed trunk drawings, such as the Walter Reed Assessment Scale, the Spinal Appearance Questionnaire, and the Trunk Appearance Perception Scale. Trunk asymmetry scales that use pictures, such as the TRACE (Trunk Aestethic Clinical Evaluation), the POTSI (Posterior Trunk Symmetry Index) and the ATSI (Anterior Trunk Symmetry Index), 2-dimensional digital photography, and surface topography can all be used to assess the aesthetic profile of subjects, allowing for objective evaluation. Conclusion. Each clinical examination should include a specific assessment of trunk asymmetry. Various instruments were developed with the goal of decreasing x-ray radiation exposure in these patients.
{"title":"Aesthetic appearance assessment in adolescents with idiopathic scoliosis","authors":"V. Živković, L. Dimitrijević, H. Čolović, D. Zlatanovic, M. Spalević, N. Savić","doi":"10.5937/afmnai40-36944","DOIUrl":"https://doi.org/10.5937/afmnai40-36944","url":null,"abstract":"Introduction. Aesthetic appearance is one of the major concerns in adolescent idiopathic scoliosis (AIS) patients and its improvement is one of the main treatment's goals. Poor trunk appearance is associated with reduced quality of life in adolescents with idiopathic scoliosis. Aim. To review instruments that have been created to evaluate poor trunk appearance in these children. Material and methods. PubMed database and the Consortium of Libraries of Serbia for Unified Acquisition - KoBSON were searched using the keywords \"adolescent scoliosis\", \"aesthetic appearance\", \"evaluation\" and \"questionnaires\". Results. In order to evaluate the aesthetic impairment in these patients, various instruments have been created. They can roughly be classed as instruments that assess subjective perception or objective aesthetic appearance. The first group consists primarily of self-administered quality of life questionnaires that include an aesthetic component, such as the Scoliosis Research Society 22 (SRS-22) questionnaire and the Italian Spinal Youth Quality of Life (ISYQoL) questionnaire, as well as visual scales based on patient-completed trunk drawings, such as the Walter Reed Assessment Scale, the Spinal Appearance Questionnaire, and the Trunk Appearance Perception Scale. Trunk asymmetry scales that use pictures, such as the TRACE (Trunk Aestethic Clinical Evaluation), the POTSI (Posterior Trunk Symmetry Index) and the ATSI (Anterior Trunk Symmetry Index), 2-dimensional digital photography, and surface topography can all be used to assess the aesthetic profile of subjects, allowing for objective evaluation. Conclusion. Each clinical examination should include a specific assessment of trunk asymmetry. Various instruments were developed with the goal of decreasing x-ray radiation exposure in these patients.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Stojanović, Milica Pešić, S. Ilić, M. Deljanin-Ilić, V. Ćirić
Introduction. Since 1999 continuous glucose monitoring (CGM) has been used to measure the amount of glucose in the interstitial fluid. CGM is crucial when it comes to developing the ambulatory glucose profile and giving information on time spent in range (TIR), percentage of time spent above and below range, as well as variability. Discussion. It was in 1992 that Campbell et al. first described white coat hyperglycaemia, who explained it as patients having elevated blood glucose levels in a clinician's office or laboratory and normal glucose levels obtained by self-monitoring. Prior to the introduction of CGM, white coat hyperglycaemia was described as the discrepancy in the levels of office glucose and self-monitoring blood glucose (SMBG). Nowadays, it may be said that a patient has white coat hyperglycaemia when they have elevated office levels and normal SMBG levels or TIR above 70% on CGM. Recognising white coat hyperglycaemia is of crucial importance for treatment as its intensification based on office glycaemia alone can lead to episodes of hypoglycaemia and a potentially lethal outcome. Should comparison be made with arterial hypertension and ambulatory blood pressure monitoring (ABPM), CGM may provide several other options: 1) masked hyperglycaemia; 2) isolated nocturnal hyperglycaemia. Conclusion. It seems logical that CGM can be used for diagnosing white coat hyperglycaemia and possibly some (new) entities. Nonetheless, the clinical significance of all these entities can only be discussed after conducting adequately designed randomised clinical trials, which we would strongly encourage.
{"title":"Can continuous glucose monitoring be used as a new tool for diagnosing white coat hyperglycaemia and possibly some other entities?","authors":"M. Stojanović, Milica Pešić, S. Ilić, M. Deljanin-Ilić, V. Ćirić","doi":"10.5937/afmnai40-37498","DOIUrl":"https://doi.org/10.5937/afmnai40-37498","url":null,"abstract":"Introduction. Since 1999 continuous glucose monitoring (CGM) has been used to measure the amount of glucose in the interstitial fluid. CGM is crucial when it comes to developing the ambulatory glucose profile and giving information on time spent in range (TIR), percentage of time spent above and below range, as well as variability. Discussion. It was in 1992 that Campbell et al. first described white coat hyperglycaemia, who explained it as patients having elevated blood glucose levels in a clinician's office or laboratory and normal glucose levels obtained by self-monitoring. Prior to the introduction of CGM, white coat hyperglycaemia was described as the discrepancy in the levels of office glucose and self-monitoring blood glucose (SMBG). Nowadays, it may be said that a patient has white coat hyperglycaemia when they have elevated office levels and normal SMBG levels or TIR above 70% on CGM. Recognising white coat hyperglycaemia is of crucial importance for treatment as its intensification based on office glycaemia alone can lead to episodes of hypoglycaemia and a potentially lethal outcome. Should comparison be made with arterial hypertension and ambulatory blood pressure monitoring (ABPM), CGM may provide several other options: 1) masked hyperglycaemia; 2) isolated nocturnal hyperglycaemia. Conclusion. It seems logical that CGM can be used for diagnosing white coat hyperglycaemia and possibly some (new) entities. Nonetheless, the clinical significance of all these entities can only be discussed after conducting adequately designed randomised clinical trials, which we would strongly encourage.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Moxifloxacin is an antibiotic used orally or parenterally in the emergency department (ED) for the treatment of various infections, especially acute exacerbation of chronic bronchitis and community-acquired pneumonia. The side effects of the drug are mainly on the gastrointestinal system, while the central nervous system side effects are rare. Case report: Herein, we present an elderly patient who had altered mental status associated with the use of moxifloxacin. Upon discontinuation of the drug, the patient quickly returned to baseline neurologic status. In the evaluation of altered mental status in elderly patients in the ED, much of the effort should be spent primarily on ruling out more complex diagnoses. However, this approach requires more invasive and advanced testing. Conclusion: Considering drug side effects among these more complicated diagnoses may increase noninvasive and radiation-free options for the patient and physician.
{"title":"Moxifloxacin-induced mental status change","authors":"S. Güler, D. Kocaşaban","doi":"10.5937/afmnai40-36485","DOIUrl":"https://doi.org/10.5937/afmnai40-36485","url":null,"abstract":"Introduction: Moxifloxacin is an antibiotic used orally or parenterally in the emergency department (ED) for the treatment of various infections, especially acute exacerbation of chronic bronchitis and community-acquired pneumonia. The side effects of the drug are mainly on the gastrointestinal system, while the central nervous system side effects are rare. Case report: Herein, we present an elderly patient who had altered mental status associated with the use of moxifloxacin. Upon discontinuation of the drug, the patient quickly returned to baseline neurologic status. In the evaluation of altered mental status in elderly patients in the ED, much of the effort should be spent primarily on ruling out more complex diagnoses. However, this approach requires more invasive and advanced testing. Conclusion: Considering drug side effects among these more complicated diagnoses may increase noninvasive and radiation-free options for the patient and physician.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Stosic, M. Stosic, Jelena D Zivadinovic, I. Veselinović
Background and Aim: The aim of the present study was to compare the effect of volatile induction and maintenance of anesthesia (VIMA) and target controlled infusion (TCI) on cardiovascular stability in New York Heart Association (NYHA) grade II patients who underwent laparoscopic cholecystectomy. Patients and methods: In the present study, 90 patients were randomized into two groups depending on whether they received VIMA or TCI. Heart rate, systolic, diastolic and mean arterial pressure were monitored continuously and recorded in five time intervals. Results: Statistical analysis showed that VIMA with sevoflurane provides better cardiocirculatory stability (less than 10% deviation from basal values for each measured parameter) than TCI group (p < 0.01). Conclusion: Volatile induction and maintenance of anesthesia with sevoflurane provides better hemodynamic stability for NYHA II patients with concomitant cardiovascular diseases compared to TCI.
{"title":"Implications of anesthetic techniques on cardiocirculatory stability in laparoscopic cholecystectomy","authors":"B. Stosic, M. Stosic, Jelena D Zivadinovic, I. Veselinović","doi":"10.5937/afmnai40-38044","DOIUrl":"https://doi.org/10.5937/afmnai40-38044","url":null,"abstract":"Background and Aim: The aim of the present study was to compare the effect of volatile induction and maintenance of anesthesia (VIMA) and target controlled infusion (TCI) on cardiovascular stability in New York Heart Association (NYHA) grade II patients who underwent laparoscopic cholecystectomy. Patients and methods: In the present study, 90 patients were randomized into two groups depending on whether they received VIMA or TCI. Heart rate, systolic, diastolic and mean arterial pressure were monitored continuously and recorded in five time intervals. Results: Statistical analysis showed that VIMA with sevoflurane provides better cardiocirculatory stability (less than 10% deviation from basal values for each measured parameter) than TCI group (p < 0.01). Conclusion: Volatile induction and maintenance of anesthesia with sevoflurane provides better hemodynamic stability for NYHA II patients with concomitant cardiovascular diseases compared to TCI.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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