Milica Labus, J. Sotirović, B. Vukomanović-Đurđević, A. Perić
Introduction. Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is an extremely rare form of invasive fungal sinusitis. The disease has a long-lasting and indolent course, so the invasion and destruction in the sinonasal and adjacent regions is progressing slowly. This disease has been reported primarily in Middle East, North Africa, India and Pakistan; however, it is very rare in western countries. It is primarily caused by Aspergillus flavus. Case Report. A 40-year-old man, who was repeatedly surgically treated for chronic rhinosinusitis with nasal polyps, was presented to our Otorhinolaryngology Department with a progressive, sudden right-sided proptosis. Contrast-enhanced paranasal sinus computed tomography (CT) showed almost complete soft tissue opacification of the sinonasal region, eroded bone structures and expansion into the right orbit. Erosion of the walls of the right frontal sinus was also seen but without intracranial propagation. Histopathological examination was necessary for the final diagnosis. The finding of granulomatous response along with fibrosis and strong inflammatory infiltrate was typical for chronic granulomatous invasive fungal sinusitis. The patient was successfully treated with a combination of surgery and postoperative medical therapy with voriconazole. To our knowledge, this is the first case of CGIFRS presented in Serbia. In addition, we reviewed the literature concerning this rare form of fungal sinusitis, especially for the Balkan region. Conclusion. Although we reported an extremely rare case of fungal sinusitis for the Balkan region, it is important to suspect on it in all cases where chronic inflammation of the paranasal sinuses does not respond to conventional treatment.
{"title":"Chronic granulomatous invasive fungal sinusitis: A review of the literature and report of a case atypical of the Balkan region","authors":"Milica Labus, J. Sotirović, B. Vukomanović-Đurđević, A. Perić","doi":"10.5937/afmnai40-37869","DOIUrl":"https://doi.org/10.5937/afmnai40-37869","url":null,"abstract":"Introduction. Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is an extremely rare form of invasive fungal sinusitis. The disease has a long-lasting and indolent course, so the invasion and destruction in the sinonasal and adjacent regions is progressing slowly. This disease has been reported primarily in Middle East, North Africa, India and Pakistan; however, it is very rare in western countries. It is primarily caused by Aspergillus flavus. Case Report. A 40-year-old man, who was repeatedly surgically treated for chronic rhinosinusitis with nasal polyps, was presented to our Otorhinolaryngology Department with a progressive, sudden right-sided proptosis. Contrast-enhanced paranasal sinus computed tomography (CT) showed almost complete soft tissue opacification of the sinonasal region, eroded bone structures and expansion into the right orbit. Erosion of the walls of the right frontal sinus was also seen but without intracranial propagation. Histopathological examination was necessary for the final diagnosis. The finding of granulomatous response along with fibrosis and strong inflammatory infiltrate was typical for chronic granulomatous invasive fungal sinusitis. The patient was successfully treated with a combination of surgery and postoperative medical therapy with voriconazole. To our knowledge, this is the first case of CGIFRS presented in Serbia. In addition, we reviewed the literature concerning this rare form of fungal sinusitis, especially for the Balkan region. Conclusion. Although we reported an extremely rare case of fungal sinusitis for the Balkan region, it is important to suspect on it in all cases where chronic inflammation of the paranasal sinuses does not respond to conventional treatment.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jelena Miolski, Maja Ješić, Vlada Bojić, S. Kovačević, J. Blagojević, V. Zdravković
Introduction/Aim. Those born small for gestational age are all newborns whose weight, length and head circumference deviate by more than minus two standard deviations in relation to the same parameters of average children of the same sex, corresponding gestational age and population. The goal is their early recognition and adequate treatment. They should be clearly distinguished from premature babies, children born before the 37th week of gestation, and it should be noted that all children born small for gestational age are always born after intrauterine growth arrest. Poor and economically underdeveloped countries show a higher prevalence of children small for gestational age. At birth, these children have a higher risk of asphyxia, infections, neurological disorders, and in the later period of life, low growth, cognitive dysfunctions, disorders of pubertal development and metabolic syndrome. If they have not achieved growth compensation by the age of four and their height is less than minus 2.5 standard deviations, treatment with recombinant growth hormone is suggested. The recommended starting dose of growth hormone is 35 mg/kg of body weight per day. Adequate adjustment of the dose is achieved by monitoring the growth rate at 6 - 12 and IGF-1 at 3 - 6 months after starting therapy, and then once a year. The treatment is stopped in the period of adolescence, when the growth rate is < 2 cm per year. Conclusion. Early recognition of children born small for gestational age provides the opportunity to avoid numerous complications later in life with adequate and timely treatment.
{"title":"Children born small for gestational age","authors":"Jelena Miolski, Maja Ješić, Vlada Bojić, S. Kovačević, J. Blagojević, V. Zdravković","doi":"10.5937/afmnai40-39513","DOIUrl":"https://doi.org/10.5937/afmnai40-39513","url":null,"abstract":"Introduction/Aim. Those born small for gestational age are all newborns whose weight, length and head circumference deviate by more than minus two standard deviations in relation to the same parameters of average children of the same sex, corresponding gestational age and population. The goal is their early recognition and adequate treatment. They should be clearly distinguished from premature babies, children born before the 37th week of gestation, and it should be noted that all children born small for gestational age are always born after intrauterine growth arrest. Poor and economically underdeveloped countries show a higher prevalence of children small for gestational age. At birth, these children have a higher risk of asphyxia, infections, neurological disorders, and in the later period of life, low growth, cognitive dysfunctions, disorders of pubertal development and metabolic syndrome. If they have not achieved growth compensation by the age of four and their height is less than minus 2.5 standard deviations, treatment with recombinant growth hormone is suggested. The recommended starting dose of growth hormone is 35 mg/kg of body weight per day. Adequate adjustment of the dose is achieved by monitoring the growth rate at 6 - 12 and IGF-1 at 3 - 6 months after starting therapy, and then once a year. The treatment is stopped in the period of adolescence, when the growth rate is < 2 cm per year. Conclusion. Early recognition of children born small for gestational age provides the opportunity to avoid numerous complications later in life with adequate and timely treatment.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"86 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Stojanović, Sara Mladenović, Bogdan Stojiljković, A. Marković, D. Pavlović, Pavle J. Ranđelović, J. Zvezdanović, L. Stanojević
Introduction. Lemon balm has been used for centuries due to its strong sedative, antimicrobial and spasmolytic effects. Besides different types of extracts and essential oils, hydrolates (by-products obtained during essential oil extraction) are preparations of aromatic medicinal plants with potential pharmacological activity. Aim. To estimate Melissa officinalis leaves hydrolate effects on gastric motility. Methods. The influence of the hydrolate was tested in vitro in a tissue bath in the rat fundus spontaneous contraction experimental model. Increasing volumes of sample (making the final concentration span 0.5 - 500 µl/ml) were successively added to the tissue bath. Results. Lower doses of the hydrolate did not produce any significant changes in the contraction patterns, while the higher ones led to a statistically significant increase in basal tone of the stomach fundus. Yet, these changes in basal tonus were still modest. Phytochemical qualitative characterization, done by liquid chromatography with ultra-high performances, showed that rosmarinic acid was dominant compound of M. officinalis hydrolate. Conclusion. Although the tested hydrolate poorly influences isolated rat gastric fundus motility, further studies could clarify its pharmacological activity and potential future application of this by-product of M. officinalis hydrodestilation.
{"title":"Lemon balm (Melissa officinalis L.) hydrolate poorly influences isolated rat gastric fundus motility","authors":"N. Stojanović, Sara Mladenović, Bogdan Stojiljković, A. Marković, D. Pavlović, Pavle J. Ranđelović, J. Zvezdanović, L. Stanojević","doi":"10.5937/afmnai40-38933","DOIUrl":"https://doi.org/10.5937/afmnai40-38933","url":null,"abstract":"Introduction. Lemon balm has been used for centuries due to its strong sedative, antimicrobial and spasmolytic effects. Besides different types of extracts and essential oils, hydrolates (by-products obtained during essential oil extraction) are preparations of aromatic medicinal plants with potential pharmacological activity. Aim. To estimate Melissa officinalis leaves hydrolate effects on gastric motility. Methods. The influence of the hydrolate was tested in vitro in a tissue bath in the rat fundus spontaneous contraction experimental model. Increasing volumes of sample (making the final concentration span 0.5 - 500 µl/ml) were successively added to the tissue bath. Results. Lower doses of the hydrolate did not produce any significant changes in the contraction patterns, while the higher ones led to a statistically significant increase in basal tone of the stomach fundus. Yet, these changes in basal tonus were still modest. Phytochemical qualitative characterization, done by liquid chromatography with ultra-high performances, showed that rosmarinic acid was dominant compound of M. officinalis hydrolate. Conclusion. Although the tested hydrolate poorly influences isolated rat gastric fundus motility, further studies could clarify its pharmacological activity and potential future application of this by-product of M. officinalis hydrodestilation.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Traumatic injury to the cervical segment of the spinal cord causes disability and quadriplegia. Upper extremity mobility and restoration of hand function for people with quadriplegia is a priority. With coordinated electrical stimulation of peripheral muscles and nerves, known as functional electrical stimulation (FES), this is possible. Upper limb stimulators are designed to increase the physical function and are controlled by users through preserved, uncoupled and limited voluntary movements. Aim. By reviewing the available literature, the aim of the paper was to prove the importance of FES in motor control and functional ability of the upper limbs of people with quadriplegia. Material and method. Using the keywords "quadriplegia", "FES", "upper extremity", "functional ability", "motor control" and "traumatic injury", the three authors searched the databases PubMed, EMBASE, SciELO, BMC, Academia according to pre-established criteria. Edu, Web of Science and Science & Technology (November 2021 - March 2022). Potential papers were selected using the Jovell and Navarro-Rubio classification of study design. Papers older than five years, papers that were not available in their entirety, or in English, were excluded. Fifty-seven papers were classified, and six were included in the research. Results. Functional electrical stimulators improved the functional ability of the upper extremities shortly after application. They cause neurophysiological changes in the central nervous system and cortical reorganization depending on the synchronization of the voluntary command and the successful execution of the planned task. Sensory stimulation is important in the preservation of neurological function because by synchronizing the voluntary command and successfully executing the planned task, neuroplasticity is stimulated. Conclusion. With the emergence of more research and analysis of the obtained results, we can expect the creation of new programs to improve the recovery process of the upper extremities, a greater degree of independence in daily life activities, and a better quality of life for people with quadriplegia.
{"title":"Functional electrical stimulation of the upper extremities of persons with quadriplegia","authors":"Ranka Ogurlić, Anka Vukićević, Emira Švraka","doi":"10.5937/afmnai40-39107","DOIUrl":"https://doi.org/10.5937/afmnai40-39107","url":null,"abstract":"Introduction. Traumatic injury to the cervical segment of the spinal cord causes disability and quadriplegia. Upper extremity mobility and restoration of hand function for people with quadriplegia is a priority. With coordinated electrical stimulation of peripheral muscles and nerves, known as functional electrical stimulation (FES), this is possible. Upper limb stimulators are designed to increase the physical function and are controlled by users through preserved, uncoupled and limited voluntary movements. Aim. By reviewing the available literature, the aim of the paper was to prove the importance of FES in motor control and functional ability of the upper limbs of people with quadriplegia. Material and method. Using the keywords \"quadriplegia\", \"FES\", \"upper extremity\", \"functional ability\", \"motor control\" and \"traumatic injury\", the three authors searched the databases PubMed, EMBASE, SciELO, BMC, Academia according to pre-established criteria. Edu, Web of Science and Science & Technology (November 2021 - March 2022). Potential papers were selected using the Jovell and Navarro-Rubio classification of study design. Papers older than five years, papers that were not available in their entirety, or in English, were excluded. Fifty-seven papers were classified, and six were included in the research. Results. Functional electrical stimulators improved the functional ability of the upper extremities shortly after application. They cause neurophysiological changes in the central nervous system and cortical reorganization depending on the synchronization of the voluntary command and the successful execution of the planned task. Sensory stimulation is important in the preservation of neurological function because by synchronizing the voluntary command and successfully executing the planned task, neuroplasticity is stimulated. Conclusion. With the emergence of more research and analysis of the obtained results, we can expect the creation of new programs to improve the recovery process of the upper extremities, a greater degree of independence in daily life activities, and a better quality of life for people with quadriplegia.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rattan, Abdulhadi Alrubaie, Sen Salih, Sajad Abdalla, Sajad Hussein, F. Tariq
Background. Body mass index (BMI) is a person's weight in kilograms (or pounds) divided by the square of height in meters (or feet). Obesity affects a wide spectrum of age groups, from the young to the elderly, and there are several eye diseases related to obesity like diabetic retinopathy, floppy eyelid syndrome, retinal vein occlusion, stroke-related vision loss, age-related macular degeneration, and possibly, refractive errors. Refractive errors (RE) are optical imperfections related to the focusing ability of the eye and are the main cause of visual impairment which may result in missed education and employment opportunities, lower productivity and impaired quality of life. Aim. The study aimed to find an association between body mass index (BMI) and refractive errors. Methodology. A cross-sectional study was designed to involve a representative sample of medical students in Al-Kindy College of medicine, from December 8, 2021 to January 10, 2022. Weight and height were measured. BMI was estimated, and their refractive error was assessed. Results. A total of 400 students participated in the study, of which 191 (47.8%) had refractive errors, whereas 209 (52.2%) were emmetropic. Thirty-seven point eight percent of the participants had BMI > 25. A significant relationship between refractive errors and all BMI groups was found (p < 0.025). Compared to normal weight group, overweight and obese groups, only the underweight group showed a significant relationship with refractive errors, p < 0.006. Conclusion. Myopia is associated with being underweight, hence the link between the two is statistically significant. The severity of this condition, however, is unaffected by body mass index. Myopia was not a concern among students with normal or high body mass index (BMI).
{"title":"A correlation between body mass index and refractive errors","authors":"S. Rattan, Abdulhadi Alrubaie, Sen Salih, Sajad Abdalla, Sajad Hussein, F. Tariq","doi":"10.5937/afmnai40-40667","DOIUrl":"https://doi.org/10.5937/afmnai40-40667","url":null,"abstract":"Background. Body mass index (BMI) is a person's weight in kilograms (or pounds) divided by the square of height in meters (or feet). Obesity affects a wide spectrum of age groups, from the young to the elderly, and there are several eye diseases related to obesity like diabetic retinopathy, floppy eyelid syndrome, retinal vein occlusion, stroke-related vision loss, age-related macular degeneration, and possibly, refractive errors. Refractive errors (RE) are optical imperfections related to the focusing ability of the eye and are the main cause of visual impairment which may result in missed education and employment opportunities, lower productivity and impaired quality of life. Aim. The study aimed to find an association between body mass index (BMI) and refractive errors. Methodology. A cross-sectional study was designed to involve a representative sample of medical students in Al-Kindy College of medicine, from December 8, 2021 to January 10, 2022. Weight and height were measured. BMI was estimated, and their refractive error was assessed. Results. A total of 400 students participated in the study, of which 191 (47.8%) had refractive errors, whereas 209 (52.2%) were emmetropic. Thirty-seven point eight percent of the participants had BMI > 25. A significant relationship between refractive errors and all BMI groups was found (p < 0.025). Compared to normal weight group, overweight and obese groups, only the underweight group showed a significant relationship with refractive errors, p < 0.006. Conclusion. Myopia is associated with being underweight, hence the link between the two is statistically significant. The severity of this condition, however, is unaffected by body mass index. Myopia was not a concern among students with normal or high body mass index (BMI).","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Fylenko, N. Roiko, Andriy Roiko, І. Starchenko, Dmytro Kuvichka, Volodymyr М Koka
Introduction. Nora's lesion or bizarre parosteal osteochondromatous proliferation is a rare benign bone neoplasm that is usually localized on the small bones of the hands. The paper was aimed at clinical, morphological and structural analysis of Nora's lesion case, the second registered in Ukraine. Case report. A 42-year-old male patient presented with complaints of painless swelling in the area of the distal 4th metacarpal bone and limited mobility of the ring finger. The diagnosis was based on a typical localization, combination of clinical, radiological, and histological methods; however, the right differential diagnosis was an important task in the present case, too. Conclusion. As there is still not enough data in the literature on this issue, further studies of Nora's lesion etiology will improve its understanding, thus treatment modes and prevention of recurrence, too.
{"title":"A case of bizarre parosteal osteochondromatous proliferation (Nora's lesion): A brief description","authors":"B. Fylenko, N. Roiko, Andriy Roiko, І. Starchenko, Dmytro Kuvichka, Volodymyr М Koka","doi":"10.5937/afmnai40-36964","DOIUrl":"https://doi.org/10.5937/afmnai40-36964","url":null,"abstract":"Introduction. Nora's lesion or bizarre parosteal osteochondromatous proliferation is a rare benign bone neoplasm that is usually localized on the small bones of the hands. The paper was aimed at clinical, morphological and structural analysis of Nora's lesion case, the second registered in Ukraine. Case report. A 42-year-old male patient presented with complaints of painless swelling in the area of the distal 4th metacarpal bone and limited mobility of the ring finger. The diagnosis was based on a typical localization, combination of clinical, radiological, and histological methods; however, the right differential diagnosis was an important task in the present case, too. Conclusion. As there is still not enough data in the literature on this issue, further studies of Nora's lesion etiology will improve its understanding, thus treatment modes and prevention of recurrence, too.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Šćepan Sinanović, T. Prodović, O. Milovanović, S. Bubanj, Miljan Krstović, Srećko Potić, J. Sekulić, Danilo Jeremic
Introduction. There are several definitions given by various anesthesiology professional organizations that explain the term procedural sedation and analgesia (PSA). The International Committee for the Advancement of PSA has defined procedural sedation as the use of anxiolytics, sedatives, hypnotics, analgesics and/or dissociative drugs to alleviate anxiety, pain and/or movement. These agents are used to facilitate the attainment of amnesia or to reduce the consciousness and/or comfort and safety of the patient during diagnostic or therapeutic procedures. The first guidelines for sedation are based on the mandatory signing of informed consent, monitoring and measuring of vital parameters, implementing a fasting regimen before sedation, possessing the skills to establish and maintain the airway, and resuscitation measures. Since PSA is most often used outside the operating room, this type of anesthesia activity is known as NORA (Non-Operating Room Anesthesia Care). Conclusion. Preprocedural evaluation and preparation, periprocedural management, monitoring and care of postprocedural recovery from PSA is similar to those of general or regional anesthesia. In conclusion, a number of logistical and practical difficulties should be noted, such as the availability of medicines and appropriate staff training, as well as the application of global guidelines on PSA.
{"title":"Challenges in procedural sedation and analgesia","authors":"Šćepan Sinanović, T. Prodović, O. Milovanović, S. Bubanj, Miljan Krstović, Srećko Potić, J. Sekulić, Danilo Jeremic","doi":"10.5937/afmnai40-38674","DOIUrl":"https://doi.org/10.5937/afmnai40-38674","url":null,"abstract":"Introduction. There are several definitions given by various anesthesiology professional organizations that explain the term procedural sedation and analgesia (PSA). The International Committee for the Advancement of PSA has defined procedural sedation as the use of anxiolytics, sedatives, hypnotics, analgesics and/or dissociative drugs to alleviate anxiety, pain and/or movement. These agents are used to facilitate the attainment of amnesia or to reduce the consciousness and/or comfort and safety of the patient during diagnostic or therapeutic procedures. The first guidelines for sedation are based on the mandatory signing of informed consent, monitoring and measuring of vital parameters, implementing a fasting regimen before sedation, possessing the skills to establish and maintain the airway, and resuscitation measures. Since PSA is most often used outside the operating room, this type of anesthesia activity is known as NORA (Non-Operating Room Anesthesia Care). Conclusion. Preprocedural evaluation and preparation, periprocedural management, monitoring and care of postprocedural recovery from PSA is similar to those of general or regional anesthesia. In conclusion, a number of logistical and practical difficulties should be noted, such as the availability of medicines and appropriate staff training, as well as the application of global guidelines on PSA.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Tooth loss and changes in tooth structure affect the quality of life of patients both from the aspect of orofacial health and general health as well. Case report. Lack of teeth reduces the ability to chew and swallow food, which significantly disrupts the function of the digestive system. Less pleasing appearance and speech disorders affect the patient's psychological status and quality of social life. Conclusion. Elderly patients represent a specific category to which special attention should be paid when solving the problem of edentulousness.
{"title":"Prosthetic rehabilitation of geriatric patients: A case report","authors":"Maja Anđelković, N. Gligorijević, M. Kostić","doi":"10.5937/afmnai39-34371","DOIUrl":"https://doi.org/10.5937/afmnai39-34371","url":null,"abstract":"Introduction. Tooth loss and changes in tooth structure affect the quality of life of patients both from the aspect of orofacial health and general health as well. Case report. Lack of teeth reduces the ability to chew and swallow food, which significantly disrupts the function of the digestive system. Less pleasing appearance and speech disorders affect the patient's psychological status and quality of social life. Conclusion. Elderly patients represent a specific category to which special attention should be paid when solving the problem of edentulousness.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Formanchuk, H. Lapshyn, M. Pokidko, A. Formanchuk, I. Vovchuk
Introduction: Neutrophil-lymphocyte ratio (NLR) is one of the laboratory biomarkers used in clinical practice to predict severity and mortality of acute pancreatitis (AP), however, there is currently insufficient information about the changes of NLR in the dynamics in relationship with other clinical and laboratory data. Aims: To assess the relationship between NLR values and other demographics, clinical and simple laboratory data in patients with acute pancreatitis. Methods: The data of two hundred twenty-nine patients with AP were analyzed. All patients were divided into two groups: the group with a positive outcome and the group with a fatal outcome. NLR was counted on the 1st, 3rd and 5th day after admission in each group. The dynamics of NLR index by groups and days, as well as its correlation with other 18 simple laboratory parameters were evaluated. Results: The level of NLR rate itself was significantly higher on the 1st, 3rd and 5th day in the group with the fatal result compared with the group with the positive result (p < 0.05). In patients with AP with the positive result of treatment, there was a gradual decrease in the rate between the 1st and the 3rd day (-21.8%) (p < 0.05). The overall dynamics of the indicator between the 1st and the 5th day was -21.5%. In contrast to the group of patients with the fatal outcome, despite the infusion therapy, there was an increase in NLR rate between the 1st and 3rd day of +15.7%. The overall dynamics between the 1st and 5th day was -34.0%. A significant negative relationship of the Spearman's rank correlation coefficient between NLR on the 1st and 3rd day with the fatal outcome was revealed. The highest reliability of this indicator was found on the 3rd day after admission (p < 0.0001). In the group of patients with a positive result, a correlation between NLR on the 1st day and stabs on the 1st day, segmental forms on the 1st day, serum amylase on the 1st day was found. A very high correlation was found with the level of lymphocytes on the 1st day (rs = -0.98, p < 0001). In the group of patients with the fatal outcome, a statistically significant correlation (p < 0.05) of moderate strength was found between the value of NLR and the following indicators: glucose level on the 1st day, total protein on the 5th day, prothrombin index on the 5th day. A high correlation was found with the level of segmental forms on the 1st day (rs = 0.7) and a very high correlation with the level of lymphocytes on the 1st day (rs = -0.99). Conclusions: There was a significant increase in NLR on the 1st, 3rd, and 5th day in the group of patients with AP with the fatal outcome compared with the group of patients with AP with the positive result. Elevated NLR levels on the 1st and 3rd day seem to be associated with hospital mortality in patients with AP. No correlation was found between NLR rate and clinical data in the group with fatal outcome. The main indicators among simple laboratory parameters for determining the
{"title":"The relationship between neutrophil-lymphocyte ratio and clinal laboratory data in acute pancreatitis","authors":"T. Formanchuk, H. Lapshyn, M. Pokidko, A. Formanchuk, I. Vovchuk","doi":"10.5937/afmnai39-34988","DOIUrl":"https://doi.org/10.5937/afmnai39-34988","url":null,"abstract":"Introduction: Neutrophil-lymphocyte ratio (NLR) is one of the laboratory biomarkers used in clinical practice to predict severity and mortality of acute pancreatitis (AP), however, there is currently insufficient information about the changes of NLR in the dynamics in relationship with other clinical and laboratory data. Aims: To assess the relationship between NLR values and other demographics, clinical and simple laboratory data in patients with acute pancreatitis. Methods: The data of two hundred twenty-nine patients with AP were analyzed. All patients were divided into two groups: the group with a positive outcome and the group with a fatal outcome. NLR was counted on the 1st, 3rd and 5th day after admission in each group. The dynamics of NLR index by groups and days, as well as its correlation with other 18 simple laboratory parameters were evaluated. Results: The level of NLR rate itself was significantly higher on the 1st, 3rd and 5th day in the group with the fatal result compared with the group with the positive result (p < 0.05). In patients with AP with the positive result of treatment, there was a gradual decrease in the rate between the 1st and the 3rd day (-21.8%) (p < 0.05). The overall dynamics of the indicator between the 1st and the 5th day was -21.5%. In contrast to the group of patients with the fatal outcome, despite the infusion therapy, there was an increase in NLR rate between the 1st and 3rd day of +15.7%. The overall dynamics between the 1st and 5th day was -34.0%. A significant negative relationship of the Spearman's rank correlation coefficient between NLR on the 1st and 3rd day with the fatal outcome was revealed. The highest reliability of this indicator was found on the 3rd day after admission (p < 0.0001). In the group of patients with a positive result, a correlation between NLR on the 1st day and stabs on the 1st day, segmental forms on the 1st day, serum amylase on the 1st day was found. A very high correlation was found with the level of lymphocytes on the 1st day (rs = -0.98, p < 0001). In the group of patients with the fatal outcome, a statistically significant correlation (p < 0.05) of moderate strength was found between the value of NLR and the following indicators: glucose level on the 1st day, total protein on the 5th day, prothrombin index on the 5th day. A high correlation was found with the level of segmental forms on the 1st day (rs = 0.7) and a very high correlation with the level of lymphocytes on the 1st day (rs = -0.99). Conclusions: There was a significant increase in NLR on the 1st, 3rd, and 5th day in the group of patients with AP with the fatal outcome compared with the group of patients with AP with the positive result. Elevated NLR levels on the 1st and 3rd day seem to be associated with hospital mortality in patients with AP. No correlation was found between NLR rate and clinical data in the group with fatal outcome. The main indicators among simple laboratory parameters for determining the","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abolfazl Afzali, Mojarrad Mohandes, Shahrbanoo Goli, H. Bagheri, Seyedmohammad Mirhosseini, H. Ebrahimi
Introduction/Aim: The use of macronutrient and micronutrient foods is associated with the duration of sleep. This study aimed to determine the effect of zinc supplements on the sleep quality of older adults. Methods: The current parallel randomized clinical trial study was performed using a convenience sampling method. One hundred and fifty older adults who met the inclusion criteria were assigned to intervention and control group. The participants in the intervention group received a daily dose of 30 mg zinc supplementation pill for 70 days and the control group did not receive any supplement. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). Serum zinc level in both groups was measured through the auto-analysis method. The questionnaire was completed and the serum level of zinc was measured twice, before the intervention and 70 days after the intervention. Results: Both groups were homogeneous in terms of demographic variables, sleep quality, and serum zinc level before the intervention. Of all, 73.3% of older adults in the intervention group and 74.7% of older adults in the control group had poor sleep quality. Sleep quality in the intervention group, as compared with the control group, significantly improved after the intervention. Furthermore, serum zinc levels in older adults in the intervention group, as compared with the control group, significantly increased after the intervention. Conclusion: Based on the results of this study, it is recommended to utilize zinc supplementation as a new therapeutic approach for improving sleep quality in older adults.
{"title":"Effect of zinc supplement on sleep quality in older adults: A randomized clinical trial study","authors":"Abolfazl Afzali, Mojarrad Mohandes, Shahrbanoo Goli, H. Bagheri, Seyedmohammad Mirhosseini, H. Ebrahimi","doi":"10.5937/afmnai39-33101","DOIUrl":"https://doi.org/10.5937/afmnai39-33101","url":null,"abstract":"Introduction/Aim: The use of macronutrient and micronutrient foods is associated with the duration of sleep. This study aimed to determine the effect of zinc supplements on the sleep quality of older adults. Methods: The current parallel randomized clinical trial study was performed using a convenience sampling method. One hundred and fifty older adults who met the inclusion criteria were assigned to intervention and control group. The participants in the intervention group received a daily dose of 30 mg zinc supplementation pill for 70 days and the control group did not receive any supplement. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). Serum zinc level in both groups was measured through the auto-analysis method. The questionnaire was completed and the serum level of zinc was measured twice, before the intervention and 70 days after the intervention. Results: Both groups were homogeneous in terms of demographic variables, sleep quality, and serum zinc level before the intervention. Of all, 73.3% of older adults in the intervention group and 74.7% of older adults in the control group had poor sleep quality. Sleep quality in the intervention group, as compared with the control group, significantly improved after the intervention. Furthermore, serum zinc levels in older adults in the intervention group, as compared with the control group, significantly increased after the intervention. Conclusion: Based on the results of this study, it is recommended to utilize zinc supplementation as a new therapeutic approach for improving sleep quality in older adults.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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