M. Deljanin-Ilić, G. Kocic, G. Lazarević, D. Simonović, M. Stojanović, S. Ilić, B. Đorđević, D. Petrović, S. Stojanović
Aim. To evaluate the influence of exercise training on inflammatory markers and exercise tolerance in coronary artery disease (CAD) patients. Patients and methods. A total of 54 subjects were enrolled in the present study, including 34 CAD patients (CAD group: 59.2 ± 8.2 years) and 20 healthy controls (C group: 54.2 ± 8.0 years). C reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC), and placental growth factor (PIGF) were determined, and an exercise test was performed in both groups at baseline and once again in CAD group after the supervised 3 weeks of aerobic exercise training. Results. At baseline, CRP, ESR and PIGF were significantly higher in the CAD group compared to the C group (p = 0.038, p = 0.019 and p = 0.002), while exercise capacity was significantly higher in the C group (p ˂ 0.01). After 3 weeks of exercise training, CRP, ESR, WBC count and PIGF significantly decreased (p = 0.048, p ˂ 0.001, p = 0.002 and p ˂ 0.001 respectively), while exercise capacity significantly increased (p ˂ 0.001) in the CAD group. In the CAD group, CRP decrease significantly correlated with WBC and PIGF decrease (r = 0.816, p = 0.002 and r = 0.988, p ˂ 0.001), as well as with exercise capacity increase (r = 0.834, p ˂ 0.001). Also, WBC decrease significantly correlated both with PIGF decrease (r = 0.768, p ˂ 0.001) and exercise capacity increase (r = 0.548, p = 0.012), while PIGF decrease significantly correlated with exercise capacity increase (r = 0.548, p = 0.013). Conclusion. Residential exercise training in CAD patients reduces inflammation, expressed through a significant decrease in CRP, ESR, WBC count and PIGF levels. Those positive changes in inflammatory markers are associated with significant improvement in exercise capacity.
的目标。评价运动训练对冠心病(CAD)患者炎症指标和运动耐量的影响。患者和方法。本研究共纳入54例受试者，其中冠心病患者34例(CAD组:59.2±8.2岁)，健康对照20例(C组:54.2±8.0岁)。测定C反应蛋白(CRP)、红细胞沉降率(ESR)、白细胞(WBC)和胎盘生长因子(PIGF)，两组在基线时进行运动测试，CAD组在监督下进行3周有氧运动训练后再次进行运动测试。结果。在基线时，CAD组的CRP、ESR和PIGF明显高于C组(p = 0.038, p = 0.019和p = 0.002)，而C组的运动能力明显高于C组(p小于0.01)。运动训练3周后，冠心病组CRP、ESR、WBC计数和PIGF显著降低(p = 0.048, p小于0.001,p = 0.002和p小于0.001)，运动能力显著提高(p小于0.001)。在CAD组中，CRP降低与WBC和PIGF降低(r = 0.816, p = 0.002和r = 0.988, p小于0.001)以及与运动能力增加(r = 0.834, p小于0.001)显著相关。WBC下降与PIGF下降(r = 0.768, p小于0.001)、运动能力增加(r = 0.548, p = 0.012)、PIGF下降与运动能力增加(r = 0.548, p = 0.013)均显著相关。结论。住宅运动训练可以减轻CAD患者的炎症，通过CRP、ESR、WBC计数和PIGF水平的显著降低来表达。这些炎症标志物的积极变化与运动能力的显著改善有关。
{"title":"Exercise training and inflammatory markers in coronary artery disease patients","authors":"M. Deljanin-Ilić, G. Kocic, G. Lazarević, D. Simonović, M. Stojanović, S. Ilić, B. Đorđević, D. Petrović, S. Stojanović","doi":"10.5937/afmnai39-36545","DOIUrl":"https://doi.org/10.5937/afmnai39-36545","url":null,"abstract":"Aim. To evaluate the influence of exercise training on inflammatory markers and exercise tolerance in coronary artery disease (CAD) patients. Patients and methods. A total of 54 subjects were enrolled in the present study, including 34 CAD patients (CAD group: 59.2 ± 8.2 years) and 20 healthy controls (C group: 54.2 ± 8.0 years). C reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC), and placental growth factor (PIGF) were determined, and an exercise test was performed in both groups at baseline and once again in CAD group after the supervised 3 weeks of aerobic exercise training. Results. At baseline, CRP, ESR and PIGF were significantly higher in the CAD group compared to the C group (p = 0.038, p = 0.019 and p = 0.002), while exercise capacity was significantly higher in the C group (p ˂ 0.01). After 3 weeks of exercise training, CRP, ESR, WBC count and PIGF significantly decreased (p = 0.048, p ˂ 0.001, p = 0.002 and p ˂ 0.001 respectively), while exercise capacity significantly increased (p ˂ 0.001) in the CAD group. In the CAD group, CRP decrease significantly correlated with WBC and PIGF decrease (r = 0.816, p = 0.002 and r = 0.988, p ˂ 0.001), as well as with exercise capacity increase (r = 0.834, p ˂ 0.001). Also, WBC decrease significantly correlated both with PIGF decrease (r = 0.768, p ˂ 0.001) and exercise capacity increase (r = 0.548, p = 0.012), while PIGF decrease significantly correlated with exercise capacity increase (r = 0.548, p = 0.013). Conclusion. Residential exercise training in CAD patients reduces inflammation, expressed through a significant decrease in CRP, ESR, WBC count and PIGF levels. Those positive changes in inflammatory markers are associated with significant improvement in exercise capacity.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shkodina, Tymur Iengalychev, K. Tarianyk, D. Boiko, N. Lytvynenko, A. Skrypnikov
Aim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completeness of the review, a second, more in-depth literature search was performed using the same electronic database with the search inquiries of increased specificity. Results: The information on pathophysiology, epidemiology, clinical features and risk factors was extracted and formed the basis for this review. Despite how widespread sleep disorders in Parkinson's disease are, there is no systematic information about their association with neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment and psychosis. In this review, we described relationships between these non-motor symptoms of Parkinson's disease, their timeline occurrence, gap in knowledge and perspectives for further research. We suppose that early treatment of sleep disorders in patients with Parkinson's disease can reduce the incidence and extent of neuropsychiatric symptoms. Conclusion: We have demonstrated multiple, multidirectional relationships between sleep disorders and neuropsychiatric symptoms. However, some of them remain unexplored. The described knowledge can be applied to further study the possibility of influencing neuropsychiatric symptoms through the correction of sleep disorders in patients with different stages of Parkinson's disease.
{"title":"Relationship between sleep disorders and neuropsychiatric symptoms in Parkinson's disease: A narrative review","authors":"A. Shkodina, Tymur Iengalychev, K. Tarianyk, D. Boiko, N. Lytvynenko, A. Skrypnikov","doi":"10.5937/afmnai39-33652","DOIUrl":"https://doi.org/10.5937/afmnai39-33652","url":null,"abstract":"Aim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completeness of the review, a second, more in-depth literature search was performed using the same electronic database with the search inquiries of increased specificity. Results: The information on pathophysiology, epidemiology, clinical features and risk factors was extracted and formed the basis for this review. Despite how widespread sleep disorders in Parkinson's disease are, there is no systematic information about their association with neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment and psychosis. In this review, we described relationships between these non-motor symptoms of Parkinson's disease, their timeline occurrence, gap in knowledge and perspectives for further research. We suppose that early treatment of sleep disorders in patients with Parkinson's disease can reduce the incidence and extent of neuropsychiatric symptoms. Conclusion: We have demonstrated multiple, multidirectional relationships between sleep disorders and neuropsychiatric symptoms. However, some of them remain unexplored. The described knowledge can be applied to further study the possibility of influencing neuropsychiatric symptoms through the correction of sleep disorders in patients with different stages of Parkinson's disease.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kilibarda, Šćepan Sinanović, S. Bubanj, Sanja Trgovčević, S. Ivanović, S. Milutinović
Background/Aim. One of the anti-epidemic measures in the COVID-19 pandemic in 2020 in Serbia was the mandatory complete ban on movement for people over 65 years of age. Two main stress factors affecting their health have been identified: intensive media coverage of the new disease and total physical and even social isolation of the elderly. The aim of this study was to assess the immediate impact of these anti-epidemic measures to combat the COVID-19 epidemic in Serbia on the health of people over 65 years old and to recognize protective factors for their health in the conditions of their obligatory isolation. Methods. The cross-sectional study was conducted on a 20‰ sample of inhabitants over 65 (184 in total) in the urban part of the city of Kruševac, in the central part of Serbia, during April and May 2020. Results. Anti-epidemic measures to combat the COVID-19 epidemic have been associated with deteriorating health in a significantly large proportion of the elderly in the sample (approximately 84%), such as unreasonable fatigue, tension, difficulties performing routine activities due to immobility, concerns, sleeping disorders, and hypertensive episodes. Gender, higher education, and material status were not related to protection and emotional well-being, but some personality factors are related to stress resilience. Conclusion. The protective personality factors for health are the respondents' inclination toward hope, having a purpose in life, faith, optimism, interest, as well a high appreciation of positive emotions in the respondent's life (love, joy, enthusiasm, closeness, and belonging) and having a fulfilled emotional life.
{"title":"Protective personality factors for stress in the elderly during COVID-19 pandemic: A cross-sectional study","authors":"T. Kilibarda, Šćepan Sinanović, S. Bubanj, Sanja Trgovčević, S. Ivanović, S. Milutinović","doi":"10.5937/afmnai39-35292","DOIUrl":"https://doi.org/10.5937/afmnai39-35292","url":null,"abstract":"Background/Aim. One of the anti-epidemic measures in the COVID-19 pandemic in 2020 in Serbia was the mandatory complete ban on movement for people over 65 years of age. Two main stress factors affecting their health have been identified: intensive media coverage of the new disease and total physical and even social isolation of the elderly. The aim of this study was to assess the immediate impact of these anti-epidemic measures to combat the COVID-19 epidemic in Serbia on the health of people over 65 years old and to recognize protective factors for their health in the conditions of their obligatory isolation. Methods. The cross-sectional study was conducted on a 20‰ sample of inhabitants over 65 (184 in total) in the urban part of the city of Kruševac, in the central part of Serbia, during April and May 2020. Results. Anti-epidemic measures to combat the COVID-19 epidemic have been associated with deteriorating health in a significantly large proportion of the elderly in the sample (approximately 84%), such as unreasonable fatigue, tension, difficulties performing routine activities due to immobility, concerns, sleeping disorders, and hypertensive episodes. Gender, higher education, and material status were not related to protection and emotional well-being, but some personality factors are related to stress resilience. Conclusion. The protective personality factors for health are the respondents' inclination toward hope, having a purpose in life, faith, optimism, interest, as well a high appreciation of positive emotions in the respondent's life (love, joy, enthusiasm, closeness, and belonging) and having a fulfilled emotional life.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahboobeh Ahmadabadi, F. Ghorat, Raha Salehabadi, Sedighe Rastaghi, M. Rad
Introduction/Aim: Hypertension is a common disorder of old age, which could be prevented by medicinal herbs. The present study aimed to evaluate the effect of lavender extract on prehypertension in the retired population. Methods: This triple-blind clinical trial was conducted on 60 retired men and women who were divided into two groups of lavender extract and placebo using the permuted block technique. Lavender extract (originating from flower part) and placebo were used twice a day (3 grams is equivalent to 3 cc each time) for two weeks. Blood pressure was measured before use, in the first and second week after use, and one week after the discontinuation of the medication to evaluate the stability of the drug effects. Data analysis was performed in STATA software version 14 at the significance level of p < 0.05. Results: Before the intervention, the mean systolic blood pressure in the lavender extract and placebo groups was 133.9 ± 9.3 mmHg and 127.3 ± 6.3 mmHg, respectively. After a one-week intervention, the mean blood pressure of the groups was 123.1 ± 12.6 mmHg and 125.8± 7.2 mmHg, respectively, while it was 120.8 ± 10.7 mmHg and 127.9 ± 2 mmHg after two weeks. One week after drug discontinuation, these levels were estimated at 123.7 ± 10.7 mmHg and 129.2 ± 10.10 mmHg, respectively. The results of repeated measures ANOVA indicated that lavender extract had significant effects on systolic and diastolic blood pressure in the intervention group (p < 0.05). Conclusion: According to the results, lavender extract was effective in prehypertension control in the retired subjects.
{"title":"Effect of the oral consumption of lavender extract (lavandula) on prehypertension in the retirees of retirement centers: A randomized clinical trial","authors":"Mahboobeh Ahmadabadi, F. Ghorat, Raha Salehabadi, Sedighe Rastaghi, M. Rad","doi":"10.5937/afmnai39-33837","DOIUrl":"https://doi.org/10.5937/afmnai39-33837","url":null,"abstract":"Introduction/Aim: Hypertension is a common disorder of old age, which could be prevented by medicinal herbs. The present study aimed to evaluate the effect of lavender extract on prehypertension in the retired population. Methods: This triple-blind clinical trial was conducted on 60 retired men and women who were divided into two groups of lavender extract and placebo using the permuted block technique. Lavender extract (originating from flower part) and placebo were used twice a day (3 grams is equivalent to 3 cc each time) for two weeks. Blood pressure was measured before use, in the first and second week after use, and one week after the discontinuation of the medication to evaluate the stability of the drug effects. Data analysis was performed in STATA software version 14 at the significance level of p < 0.05. Results: Before the intervention, the mean systolic blood pressure in the lavender extract and placebo groups was 133.9 ± 9.3 mmHg and 127.3 ± 6.3 mmHg, respectively. After a one-week intervention, the mean blood pressure of the groups was 123.1 ± 12.6 mmHg and 125.8± 7.2 mmHg, respectively, while it was 120.8 ± 10.7 mmHg and 127.9 ± 2 mmHg after two weeks. One week after drug discontinuation, these levels were estimated at 123.7 ± 10.7 mmHg and 129.2 ± 10.10 mmHg, respectively. The results of repeated measures ANOVA indicated that lavender extract had significant effects on systolic and diastolic blood pressure in the intervention group (p < 0.05). Conclusion: According to the results, lavender extract was effective in prehypertension control in the retired subjects.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mirjana Petrović-Lazić, S. Babac, Ivana Ilić-Savić
Introduction: Quality of life is a state of complete physical, mental and social well-being. Due to the COVID-19 pandemic, which led to changes in the daily routine, there was a change in the psychosocial functioning of individuals. Given that laryngectomized patients belong to a vulnerable group that requires psychological support after surgery, specific epidemiological measures during the COVID-19 pandemic could only further increase the fear and reluctance that is especially pronounced after surgery. Aim: The aim of this study was to investigate whether there was a link between the quality of life of laryngectomized patients and the COVID-19 pandemic. Method: The literature review was performed through the Google Scholar Advanced Search search engine and the Consortium of Libraries of Serbia for Unified Acqusition - KoBSON. Results: The first wave of the COVID-19 pandemic significantly disrupted the emotional well-being of patients with head and neck cancer. These patients became even more anxious due to the high mortality from the COVID-19 viral infection, hospital occupancy and missed therapeutic examinations. The need for togetherness, impaired concentration and attention, irritability and fear that family members might suffer from a deadly disease were the most common behavioral problems identified during the COVID-19 pandemic. Conclusion: The psychological burden associated with the direct and indirect effects of the COVID-19 pandemic should not be overlooked, given the fact that laryngectomized patients have twice the risk of suicide compared to patients who have undergone other types of cancer. Assessing the quality of life in laryngectomized patients is very important because it enables the timely identification of mental disorders and suggests the necessary support measures.
{"title":"The impact of the COVID-19 pandemic on the quality of life of laryngectomized patients","authors":"Mirjana Petrović-Lazić, S. Babac, Ivana Ilić-Savić","doi":"10.5937/afmnai39-36517","DOIUrl":"https://doi.org/10.5937/afmnai39-36517","url":null,"abstract":"Introduction: Quality of life is a state of complete physical, mental and social well-being. Due to the COVID-19 pandemic, which led to changes in the daily routine, there was a change in the psychosocial functioning of individuals. Given that laryngectomized patients belong to a vulnerable group that requires psychological support after surgery, specific epidemiological measures during the COVID-19 pandemic could only further increase the fear and reluctance that is especially pronounced after surgery. Aim: The aim of this study was to investigate whether there was a link between the quality of life of laryngectomized patients and the COVID-19 pandemic. Method: The literature review was performed through the Google Scholar Advanced Search search engine and the Consortium of Libraries of Serbia for Unified Acqusition - KoBSON. Results: The first wave of the COVID-19 pandemic significantly disrupted the emotional well-being of patients with head and neck cancer. These patients became even more anxious due to the high mortality from the COVID-19 viral infection, hospital occupancy and missed therapeutic examinations. The need for togetherness, impaired concentration and attention, irritability and fear that family members might suffer from a deadly disease were the most common behavioral problems identified during the COVID-19 pandemic. Conclusion: The psychological burden associated with the direct and indirect effects of the COVID-19 pandemic should not be overlooked, given the fact that laryngectomized patients have twice the risk of suicide compared to patients who have undergone other types of cancer. Assessing the quality of life in laryngectomized patients is very important because it enables the timely identification of mental disorders and suggests the necessary support measures.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71196008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. The key links in the etiology and pathogenesis of periodontal tissue diseases are the quantitative and qualitative changes in the composition of the microflora of the oral cavity, with the simultaneous deterioration of oral hygiene, and reduction of local and general immunity, which occurs more often in the presence of somatic diseases. Aims. The aim of the paper was to study the features of the microbiocenosis of periodontal tissues and the production of hydrogen peroxide by gum symbionts in adolescents with catarrhal gingivitis and chronic gastroduodenitis. Methods. The condition of the microbiocenosis of the gums of 83 adolescents from 12 to 18 years, which was divided into groups depending on the diagnosed catarrhal gingivitis and chronic gastroduodenitis, was studied. Bacteriological examination was performed to isolate pure cultures of microorganisms and to identify them according to generally accepted microbiological methods. The ability of the selected cultures to produce hydrogen peroxide was studied on an indicator medium with potassium-iodine-starch system, by the iodometric method. Results. The results of microbiological studies showed significant changes in qualitative and quantitative indicators of the microbiocenosis of the gingival mucosa in the affected area of patients with gingivitis, compared with dentally and somatically healthy individuals in the control group. In the group of clinically healthy adolescents, hydrogen peroxide producers were found on the mucous membrane of the gums only in 5.0 ± 1.15% of the examinees. In catarrhal gingivitis, hydrogen peroxide producers were found in 52.4 ± 2.4 % of the examined main group subjects (p < 0.01) and in the 50.0 ± 2.5 % of the examined comparison group subjects (p < 0.01). Conclusion. Among adolescents with catarrhal gingivitis, which occurs on the background of chronic gastroduodenitis, there were more pronounced quantitative and qualitative changes in the microbiocenosis of the gums. The hydrogen peroxide produced by them can act as an additional damaging factor in the pathogenesis of the inflammatory process of the gingival area.
{"title":"Features of microbiocenosis and production of hydrogen peroxide by gum symbionts in adolescents with catarrhal gingivitis and chronic gastroduodenitis","authors":"I. Lisetska, Mikola Rozhko","doi":"10.5937/afmnai39-31515","DOIUrl":"https://doi.org/10.5937/afmnai39-31515","url":null,"abstract":"Introduction. The key links in the etiology and pathogenesis of periodontal tissue diseases are the quantitative and qualitative changes in the composition of the microflora of the oral cavity, with the simultaneous deterioration of oral hygiene, and reduction of local and general immunity, which occurs more often in the presence of somatic diseases. Aims. The aim of the paper was to study the features of the microbiocenosis of periodontal tissues and the production of hydrogen peroxide by gum symbionts in adolescents with catarrhal gingivitis and chronic gastroduodenitis. Methods. The condition of the microbiocenosis of the gums of 83 adolescents from 12 to 18 years, which was divided into groups depending on the diagnosed catarrhal gingivitis and chronic gastroduodenitis, was studied. Bacteriological examination was performed to isolate pure cultures of microorganisms and to identify them according to generally accepted microbiological methods. The ability of the selected cultures to produce hydrogen peroxide was studied on an indicator medium with potassium-iodine-starch system, by the iodometric method. Results. The results of microbiological studies showed significant changes in qualitative and quantitative indicators of the microbiocenosis of the gingival mucosa in the affected area of patients with gingivitis, compared with dentally and somatically healthy individuals in the control group. In the group of clinically healthy adolescents, hydrogen peroxide producers were found on the mucous membrane of the gums only in 5.0 ± 1.15% of the examinees. In catarrhal gingivitis, hydrogen peroxide producers were found in 52.4 ± 2.4 % of the examined main group subjects (p < 0.01) and in the 50.0 ± 2.5 % of the examined comparison group subjects (p < 0.01). Conclusion. Among adolescents with catarrhal gingivitis, which occurs on the background of chronic gastroduodenitis, there were more pronounced quantitative and qualitative changes in the microbiocenosis of the gums. The hydrogen peroxide produced by them can act as an additional damaging factor in the pathogenesis of the inflammatory process of the gingival area.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: FH is an autosomal dominant disease of lipid metabolism. Hypercholesterolemia, xanthomas, and death from early coronary artery disease (CAD) are common in this disease due to a mutation in the LDLR, Apo-B100 or PCSK9 genes. Case report: A 4-year-old male patient with a very rare heterozygous c.1730G > C (p.Trp577Ser) variation in exon 12 of the low-density lipoprotein receptor (LDLR) gene that causes familial hypercholesterolemia (FH) was reported. As in this case, the heterozygous form may not show any symptoms in the first decade. This variation is region specific. Therefore, region-specific diagnostic criteria should be developed. Conclusion: We aimed to contribute to the literature on the development of diagnostic criteria by discussing the patient's condition with the clinical results.
简介:FH是一种常染色体显性脂质代谢疾病。由于LDLR、Apo-B100或PCSK9基因突变，高胆固醇血症、黄瘤和早期冠状动脉疾病(CAD)导致的死亡在这种疾病中很常见。病例报告:报告了一例4岁男性患者，低密度脂蛋白受体(LDLR)基因第12外显子出现罕见的杂合C . 1730g > C (p.Trp577Ser)变异，导致家族性高胆固醇血症(FH)。在这种情况下，杂合子型在头十年可能不会表现出任何症状。这种变化是地区特有的。因此，应制定地区特异性诊断标准。结论:我们的目的是通过讨论患者的病情和临床结果来促进诊断标准的发展。
{"title":"Heterozygous c.1730G > C (p.Trp577Ser) variation in a case with familial hypercholesterolemia","authors":"Mustafa Doğan, M. Koksal, R. Eroz","doi":"10.5937/afmnai39-35609","DOIUrl":"https://doi.org/10.5937/afmnai39-35609","url":null,"abstract":"Introduction: FH is an autosomal dominant disease of lipid metabolism. Hypercholesterolemia, xanthomas, and death from early coronary artery disease (CAD) are common in this disease due to a mutation in the LDLR, Apo-B100 or PCSK9 genes. Case report: A 4-year-old male patient with a very rare heterozygous c.1730G > C (p.Trp577Ser) variation in exon 12 of the low-density lipoprotein receptor (LDLR) gene that causes familial hypercholesterolemia (FH) was reported. As in this case, the heterozygous form may not show any symptoms in the first decade. This variation is region specific. Therefore, region-specific diagnostic criteria should be developed. Conclusion: We aimed to contribute to the literature on the development of diagnostic criteria by discussing the patient's condition with the clinical results.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Lung cancer is the leading cause of mortality from cancer across the world. In this study, the use of serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in the diagnosis, prognosis and treatment response evaluation in lung cancer was investigated. Materials and Method: NCL and NPM1 levels of serum samples taken before chemotherapy and after 3-4 courses of chemotherapy from the control group and the patients diagnosed with lung cancer were studied using ELISA method. Results: Serum NCL and NPM1 levels of the patients were higher than of the controls (p = 0.085 for NCL, p = 0.000 for NPM1). NCL and NPM1 levels by histopathologic type were significantly higher in adenocarcinoma than in squamous cell carcinoma (p < 0.05 for each). In view of the treatment responses to chemotherapeutic agents, there was a statistically insignificant difference between the values before and after chemotherapy (p > 0.05 for each). Conclusion: High serum NCL and NPM1 levels were found to correlate with poor prognosis, poor treatment response and low survival rate. It can be concluded that serum NCL and NPM1 levels in lung cancer can be used as diagnostic and prognostic markers for the disease.
{"title":"Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer?","authors":"G. Akın, O. Eşbah, R. Eröz","doi":"10.5937/afmnai39-35741","DOIUrl":"https://doi.org/10.5937/afmnai39-35741","url":null,"abstract":"Aim: Lung cancer is the leading cause of mortality from cancer across the world. In this study, the use of serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in the diagnosis, prognosis and treatment response evaluation in lung cancer was investigated. Materials and Method: NCL and NPM1 levels of serum samples taken before chemotherapy and after 3-4 courses of chemotherapy from the control group and the patients diagnosed with lung cancer were studied using ELISA method. Results: Serum NCL and NPM1 levels of the patients were higher than of the controls (p = 0.085 for NCL, p = 0.000 for NPM1). NCL and NPM1 levels by histopathologic type were significantly higher in adenocarcinoma than in squamous cell carcinoma (p < 0.05 for each). In view of the treatment responses to chemotherapeutic agents, there was a statistically insignificant difference between the values before and after chemotherapy (p > 0.05 for each). Conclusion: High serum NCL and NPM1 levels were found to correlate with poor prognosis, poor treatment response and low survival rate. It can be concluded that serum NCL and NPM1 levels in lung cancer can be used as diagnostic and prognostic markers for the disease.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Asthma is one of the most common chronic respiratory diseases in the world, standing for the most frequent cause for hospitalization and emergency cases. Respiratory viruses are the most triggering cause. Aim: To assess the role of viral infections, especially COVID-19, in the pathogenesis of asthma initiation and exacerbations. Method: Electronic search was done for the manuscripts focusing on asthma as a risk factor for complications after COVID-19 infection. The outcomes were titles, materials, methods and classified studies related or not related to the review study. Three hundred publications were identified and only ten studies were selected for analysis. Seven studies were review, one retrospective, one longitudinal cohort study and one letter to the editor. Results: The included literature sources have highlighted different effect of asthma on COVID-19 progression. Asthma can be triggered by this virus and asthmatic patients with COVID-19 should not stop their treatment. Others suggest that asthma does not appear to be a significant risk factor for developing severe COVID-19 requiring hospitalization or intubation. Conclusions: Asthma is considered as comorbidity factor leading to complications and mortality in subjects infected with COVID-19.
{"title":"Asthma as a risk factor for The progression of COVID-19","authors":"B. Mahdi","doi":"10.5937/afmnai39-33234","DOIUrl":"https://doi.org/10.5937/afmnai39-33234","url":null,"abstract":"Background: Asthma is one of the most common chronic respiratory diseases in the world, standing for the most frequent cause for hospitalization and emergency cases. Respiratory viruses are the most triggering cause. Aim: To assess the role of viral infections, especially COVID-19, in the pathogenesis of asthma initiation and exacerbations. Method: Electronic search was done for the manuscripts focusing on asthma as a risk factor for complications after COVID-19 infection. The outcomes were titles, materials, methods and classified studies related or not related to the review study. Three hundred publications were identified and only ten studies were selected for analysis. Seven studies were review, one retrospective, one longitudinal cohort study and one letter to the editor. Results: The included literature sources have highlighted different effect of asthma on COVID-19 progression. Asthma can be triggered by this virus and asthmatic patients with COVID-19 should not stop their treatment. Others suggest that asthma does not appear to be a significant risk factor for developing severe COVID-19 requiring hospitalization or intubation. Conclusions: Asthma is considered as comorbidity factor leading to complications and mortality in subjects infected with COVID-19.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. The coronavirus caused the pandemic COVID-19 that has an extensive influence in the world. The virus enters and infects body cells through superficial protein ACE2. Each cell possessing ACE2 is potentially vulnerable to this virus. Since the respiratory system is exposed to the environment and has ACE2, it is one of the first candidates infected by the virus. One of the considerable complications in the severe stage of COVID-19 is an intense adaptive immunological response that is detrimental to body organs. Methods. This is a review article. All relevant articles which were accessible were reviewed. Results. Some drugs of abuse may have an adverse or beneficial influence on the disease, and their simultaneity with COVID-19 is remarkable. Nicotine and cholinergic nicotinic receptor agonists seem to decrease the cell's membrane superficial ACE2 protein number; thus, they would be appropriate candidates for COVID-19 prevention and expansion. Both opioids and cannabinoids attenuate the immune system and seem to be adverse for disease incidence but can be beneficial for the severe stage of COVID19. The antitussive effect of some opioids would be advantageous. Furthermore, some opioids are substrates for ACE2 and they bind it. Therefore, they would be an appropriate candidate to design a drug covering ACE2 with a high affinity to prevent coronavirus infection. Conclusion. Some drugs, such as nicotine and opioids, may have beneficial effects on preventing or reducing COVID-19 complications.
{"title":"Smoke, nicotine, opioids, and cannabinoids effects on the ACE2 protein level and possibility of COVID-19 infection: Suggesting potential preventives and therapeutics","authors":"Roshanak Ghobadian, H. Khaleghzadeh-Ahangar","doi":"10.5937/afmnai39-33402","DOIUrl":"https://doi.org/10.5937/afmnai39-33402","url":null,"abstract":"Introduction. The coronavirus caused the pandemic COVID-19 that has an extensive influence in the world. The virus enters and infects body cells through superficial protein ACE2. Each cell possessing ACE2 is potentially vulnerable to this virus. Since the respiratory system is exposed to the environment and has ACE2, it is one of the first candidates infected by the virus. One of the considerable complications in the severe stage of COVID-19 is an intense adaptive immunological response that is detrimental to body organs. Methods. This is a review article. All relevant articles which were accessible were reviewed. Results. Some drugs of abuse may have an adverse or beneficial influence on the disease, and their simultaneity with COVID-19 is remarkable. Nicotine and cholinergic nicotinic receptor agonists seem to decrease the cell's membrane superficial ACE2 protein number; thus, they would be appropriate candidates for COVID-19 prevention and expansion. Both opioids and cannabinoids attenuate the immune system and seem to be adverse for disease incidence but can be beneficial for the severe stage of COVID19. The antitussive effect of some opioids would be advantageous. Furthermore, some opioids are substrates for ACE2 and they bind it. Therefore, they would be an appropriate candidate to design a drug covering ACE2 with a high affinity to prevent coronavirus infection. Conclusion. Some drugs, such as nicotine and opioids, may have beneficial effects on preventing or reducing COVID-19 complications.","PeriodicalId":7132,"journal":{"name":"Acta Facultatis Medicae Naissensis","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71195772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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