3D printing in medicine最新文献

Background: Total ear reconstruction in patients with microtia remains a complex aesthetic and technical challenge. Accurate positioning and customization of porous polyethylene implants are critical, yet current methods often rely on manual planning and intraoperative adjustments.

Methods: At Schneider Children's Medical Center, high-resolution 3D facial scans or CT data were used to design patient-specific preoperative jigs and a custom single-piece implant. The jig guided precise ear positioning using facial landmarks and incorporated vascular mapping via CTA to identify branches of the superficial temporal artery. BioMed Elastic 50A Resin was used for jig printing, and the implant was tailored to patient age and anticipated ear growth.

Results: The technique enabled accurate ear alignment with the contralateral ear, minimized intraoperative adjustments, and eliminated the need for implant assembly. The integration of vascular mapping into the jig improved flap design and may reduce complications. Compared to traditional methods, this 3D-guided approach demonstrated improved positioning accuracy, reduced operative time, and enhanced aesthetic predictability.

Conclusions: This 3D-guided technique streamlines ear reconstruction and offers an efficient and reproducible solution that improves surgical planning and outcomes in patients with microtia.

Background: Three-dimensional (3D) printing is transforming medical education through the production of highly accurate anatomical models and personalised surgical training tools. Despite its growing influence, comprehensive bibliometric assessments in this domain remain scarce. This study aims to map the intellectual landscape and research trends of 3D printing in medical education from 2010 to 2025, offering evidence-based guidance for future innovation.

Methods: A systematic literature search was conducted in Web of Science Core Collection and PubMed for original articles and reviews related to 3D printing in medical education. CiteSpace was employed to construct and visualise collaboration, co-occurrence, and co-citation networks.

Results: The study included 302 articles from 96 institutions across 49 countries. The United States of America led in publication output, followed by China and Australia. Curtin University, the University of Toronto, and Mayo Clinic were the top three publishing institutions. The most prolific author published 11 papers, while the highest number of cited author as defined by co-citation analysis was 79. "Anatomical Sciences Education" was the most published-in and cited journal. The co-citation network analysis identified 12 thematic clusters-spanning medical modelling, anatomical education, and biomechanical testing-interconnected through pivotal high-centrality publications, illustrating the interdisciplinary expansion and evolving applications of 3D printing in medical education. Keyword analysis identified three major research hotspots: skill development and pedagogical validation, clinical surgical planning and doctor-patient communication, and emerging technologies with cross-disciplinary integration.

Conclusion: This bibliometric analysis highlights an ongoing paradigm shift in 3D printing for medical education-from initial technical exploration toward rigorous validation of educational efficacy. Current research hotspots encompass anatomical modelling, surgical simulation, and AI/AR integration. However, persistent challenges such as limited dynamic simulation capabilities, high costs, and the absence of standardised assessment frameworks hinder progress. To realise meaningful educational transformation, strengthened interdisciplinary collaboration and technological innovation are essential to advance beyond technical demonstration toward tangible pedagogical improvement.

Clinical trial number: Not applicable.

Introduction: Acetaminophen is a widely used antipyretic and analgesic treatment. Becuase oral administration poses a risk of acute liver failure, researchers are exploring alternative routes of administration using 3D printing.

Methods: This study reports a novel 3D-printed suppository using hot melt extrusion and melt deposition molding technologies. Through excipients screening, process screening and 3D printing, the production can be filtered to the most optimal state. After successfully prepared 3D printed acetaminophen suppository, the suppository's performance and pharmacokinetics profile were also evaluated.

Results: Prepared 3D printed suppository has a complete appearance, smooth interlayer stacking and qualified content determination with over 90% within 6 hours' in vitro release trend. The 3D printing acetaminophen suppository also has better release and distribution curve than the marketing acetaminophen suppository.

Conclusion: The obtained product has a complete appearance, smooth interlayer stacking and stable drug active molecules (API) at the test temperature. Melt deposition molding technologies offers a viable option for the 3D printing preparation of acetaminophen suppository.