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Unexpected Delayed Rectal Perforation after Endoscopic Submucosal Dissection 内镜下黏膜下解剖术后意外延迟性直肠穿孔
Pub Date : 2018-10-15 DOI: 10.19080/ARGH.2018.11.555813
V. Giorgio
Superficial gastrointestinal neoplasia may be removed endoscopically.ESD (Endoscopic submucosal dissection) isaneffectiveandsafe procedurewhich allows “en bloc” resection of superficial gastrointestinal lesions.The most common adverse events ofESD are perforation and bleeding.Late perforation are rare and occur in 0.22% according to literature.We report a case of delayedrectal perforation, occurring 16days after ESDof a 65 x 35-mm laterally spreading tumor (LST) nodular mixed type(G-MIX), ofthe rectum.The perforation wascompletely unexpected because ofabsence of post-ESD risk factors and the long period of wellness of the patient after the procedure.
浅表胃肠道肿瘤可在内镜下切除。内镜下粘膜剥离术(ESD)是一种有效且安全的手术,可以“整体”切除浅表胃肠道病变。esd最常见的不良反应是穿孔和出血。据文献报道,晚期穿孔罕见,发生率为0.22%。我们报告一例迟发性直肠穿孔,发生在65 x 35毫米的直肠横向扩散肿瘤(LST)结节混合型(G-MIX)的esd16天后。穿孔是完全出乎意料的,因为没有esd后的危险因素,而且手术后患者的健康状况很长。
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引用次数: 0
Rare Recurrence of Hepatocellular Carcinoma Greater than 6 Years after Living Donor Liver Transplant 活体肝移植术后6年以上肝癌罕见复发
Pub Date : 2018-10-10 DOI: 10.19080/ARGH.2018.11.555810
N. Duong
Living donor liver transplant (LDLT) for patients within Milan criteria (one lesion smaller than 5 cm; up to 3 lesions smaller than 3 cm, no extrahepatic manifestations, no evidence of gross vascular invasion) has been an evolving modality for the treatment of hepatocellular carcinoma (HCC) in the last decade [1,2,3]. Orthotopic liver transplant (OLT) was once considered an experimental approach in the pediatric population has now gained its popularity in the management of liver cancer in adults and has led to shortening of time on the liver transplant (LT) waitlist. Observational studies have shown comparable outcomes between LDLT and deceased donor liver transplant (DDLT) with regards to overall survival and disease-free survival rates. Unfortunately, recurrence post LDLT as with DDLT remains an ongoing issue and rates up to 10% have been reported at 4 years post-transplant [4].
活体供肝移植(LDLT)适用于符合米兰标准的患者(一个病变小于5厘米;在过去的十年中,肝细胞癌(HCC)的治疗方式不断发展,包括3个小于3cm的病变,无肝外表现,无明显血管侵犯的证据[1,2,3]。原位肝移植(OLT)曾经被认为是儿科人群的一种实验性方法,现在在成人肝癌的治疗中得到了普及,并缩短了肝移植(LT)等待名单上的时间。观察性研究表明,LDLT和死亡供体肝移植(DDLT)在总生存率和无病生存率方面具有可比性。不幸的是,与DDLT一样,LDLT术后的复发仍然是一个持续存在的问题,据报道,移植后4年的复发率高达10%。
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引用次数: 0
HER-2 Overexpression in Gastric and Gastroaesophageal Cancer: A Different Disease among Gastric Adenocarcinoma Subtypes HER-2在胃和胃食管癌症中的过度表达:不同类型胃腺癌的一种不同疾病
Pub Date : 2018-10-09 DOI: 10.19080/ARGH.2018.11.555809
C. Caglevic
Gastric cancer and gastroesophageal junction adenocarcinoma is a common malignancy worldwide, in particular in Japan and in the Pacific coast of Latin America. Unless early diagnosis is performed, this disease carries a bad prognosis with a high mortality rate regardless of the use of standard treatments. A subgroup of this patients, probably close to a 20 percent, carry HER 2 mutations that result in HER 2 overepression. Targeted treatment to block HER 2 in the first line of treatment in the metastatic setting has resulted in positive outcomes when adding trastuzumab to standard chemotherapy, nonetheless no other HER 2 targeted treatments have reported benefit in this malignancy. Clinical trials are currently ongoing to evaluate the benefit of HER 2 blockade as perioperative treatment for patients that overexpress HER 2.
癌症和胃食管交界腺癌是世界范围内常见的恶性肿瘤,尤其是在日本和拉丁美洲太平洋沿岸。除非进行早期诊断,否则无论使用标准治疗,这种疾病的预后都很差,死亡率很高。这类患者的一个亚组,可能接近20%,携带HER2突变,导致HER2过度表达。当在标准化疗中加入曲妥珠单抗时,在转移性环境中的一线治疗中阻断HER 2的靶向治疗已产生积极结果,尽管没有其他HER 2靶向治疗报告对这种恶性肿瘤有益。目前正在进行临床试验,以评估HER2阻断作为过度表达HER2患者围手术期治疗的益处。
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引用次数: 0
Can Treatment Lead to Chronic Diarrhea in a Young Adult? 治疗会导致年轻人慢性腹泻吗?
Pub Date : 2018-10-09 DOI: 10.19080/argh.2018.11.555807
S. Sundaram
Rituximab may cause hypogammaglobulinemia in a subset of patients, especially if given in multiple cycles. Early clinical trial data suggested that hypogammaglobulinemia is transient, however subsequent reports have described hypogammaglobulinemia that is both persistent and clinically significant, necessitating immunoglobulins therapy in some cases [1-5]. Gastrointestinal disease is identified in approximately 10 to 20 percent of these patients and may be the presenting symptom in some [6]. Many of these disorders mimic classic forms of disease (in the absence of immunodeficiency) such as celiac sprue, inflammatory bowel disease (IBD), and pernicious anemia but differ in pathogenesis and are often unresponsive to conventional therapies. Gastroenterologists therefore must be able to diagnose and treat patients with immunodeficiency.
利妥昔单抗可能会导致一部分患者出现低丙种球蛋白血症,尤其是在多个周期内给药的情况下。早期临床试验数据表明,低丙种球蛋白血症是暂时性的,但随后的报告描述了持续存在且具有临床意义的低丙种球蛋白血症,在某些情况下需要免疫球蛋白治疗[1-5]。胃肠道疾病约占这些患者的10%至20%,可能是一些患者的主要症状[6]。这些疾病中的许多都模仿了经典的疾病形式(在没有免疫缺陷的情况下),如乳糜泻、炎症性肠病(IBD)和恶性贫血,但发病机制不同,通常对传统疗法没有反应。因此,胃肠科医生必须能够诊断和治疗免疫缺陷患者。
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引用次数: 0
Study on the Role of Colonoscopic Biopsy in Rectal Bleeding Patients with Ulcerated Hyperemic Mucosa only 结肠镜活检在单纯溃疡性高血粘膜直肠出血患者中的作用研究
Pub Date : 2018-10-05 DOI: 10.19080/argh.2018.11.555805
D. Badary
There are several etiologies for rectal bleeding and a complete evaluation and early diagnosis is very important. Bleeding per rectum ranging from mild conditions requiring little or no treatment to severe and life-threatening ones requiring immediate intervention according to the etiologies [3]. The etiologies include hemorrhoids, anal fissures, solitary rectal ulcer, inflammatory bowel disease (IBD), diverticulosis, proctitis, ischemic colitis, infectious colitis, colonic polyps and cancer colon. Proctosigmoidoscopy followed by colonoscopy is the examination of choice for diagnosis and treatment of patients complaining of rectal bleeding [4]. As number of cases with colonoscopy shows only ulcerated hyperemic mucosa is not low, we have performed this study in order to determine the role of colonoscopy in determining the cause of bleeding per rectum in those patients by histopathological evaluation of their biopsies.
直肠出血有几种病因,完整的评估和早期诊断非常重要。直肠出血的范围从需要很少治疗或不需要治疗的轻度疾病到需要根据病因立即干预的严重和危及生命的疾病[3]。病因包括痔疮、肛裂、直肠孤立性溃疡、炎症性肠病(IBD)、憩室病、直肠炎、缺血性结肠炎、感染性结肠炎、结肠息肉和癌症结肠。直肠结肠镜检查是诊断和治疗直肠出血患者的首选检查[4]。由于结肠镜检查显示只有溃疡充血粘膜的病例数量并不低,我们进行了这项研究,以通过对这些患者活检的组织病理学评估,确定结肠镜检查在确定这些患者每个直肠出血原因中的作用。
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引用次数: 0
Post Hepatectomy Liver Failure in Nutshell Nutshell肝切除术后肝功能衰竭
Pub Date : 2018-10-05 DOI: 10.19080/ARGH.2018.11.555804
S. Subramaniam
Defining what is PHLF and criteria to diagnose it were equally difficult as treating a PHLF. The International Study Group of Liver Surgery: considering the normal postoperative course of serum bilirubin concentration and International Normalized Ratio defined PHLF as the impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased INR and concomitant hyperbilirubinemia on or after postoperative day 5 [1].
定义什么是PHLF和诊断标准与治疗PHLF同样困难。国际肝脏外科研究组:考虑到术后血清胆红素浓度和国际标准化比率的正常过程,将PHLF定义为肝脏维持其合成、排泄和排毒功能的能力受损,其特征是INR升高,并在术后第5天或之后伴有高胆红素血症。
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引用次数: 1
Gallbladder Cancer: Epidemiology, Diagnosis and Treatment 胆囊癌:流行病学、诊断和治疗
Pub Date : 2018-10-04 DOI: 10.19080/ARGH.2018.11.555802
M. K. Bhardwaj
World is facing a lot of problems in now a days. Among these, carcinomas are one of them. An estimated 169.3 million years of healthy life were lost globally because of cancer in 2008.1 About 1,688,780 new cases of cancer are expected to diagnose in year 2017 in US.2 Worldwide there will be 23.6 million new cases of cancer each year by 2030 (estimated) [1]. In 2012, an estimated 8.2 million people died from cancer worldwide [1].
当今世界面临着许多问题。其中,癌症就是其中之一。2008年,全球因癌症而损失的健康寿命估计为1.693亿年。预计2017年美国将诊断出约1,688,780例新的癌症病例。到2030年,全球每年将有2360万例新的癌症病例(估计)。2012年,全球约有820万人死于癌症。
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引用次数: 0
Combined Management Approach for Gastric & Extra-Gastric Dieulafoy’s Lesions 胃及胃外双侧病变的联合治疗方法
Pub Date : 2018-10-04 DOI: 10.19080/ARGH.2018.10.555800
M. Bassiony
Introduction: Dieulafoy’s lesions are under-diagnosed and with considerable rate of re-bleeding. They are common causes of obscure gastrointestinal bleeding. These are 3 cases of Dieulafoy’s lesion, one gastric & two are extra-gastric. The first case was an 11-year-old girl presented by recurrent hematemesis & melena. She was secured by endoscopic banding after adrenaline injection. The second case was a 19-year-old male who had multiple recurrent attacks of melena. Initial upper endoscopy was normal but angiography showed contrast extravasation at the first part of duodenum secured by coil embolization but another bleeding episode occurred 3 weeks later from an aberrant nearby vessel that was secured by endoscopic hemoclipping. The third patient was a 47- year-old man presented by hematochezia. Colonoscopy showed oozing from an aberrant vessel in the descending colon secured by endoscopic argon plasma coagulation and hemoclipping. Two days later, all three patients underwent endoscopic ultrasonography (EUS) which confirmed complete hemostasis. Conclusion: GI endoscopy plus angiography followed by EUS is an effective approach for a better management (diagnosis, treatment & follow up) of bleeding Dieulafoy’s lesions with a markedly lower rate of recurrence & mortality.
引言:Dieulafoy的病变诊断不足,再出血率相当高。它们是不明原因胃肠道出血的常见原因。这是3例Dieulafoy病变,一例为胃,两例为胃外病变。第一个病例是一名11岁的女孩,她反复出现吐血和黑便。注射肾上腺素后,她通过内窥镜束带固定。第二个病例是一名19岁的男性,他有多次黑色素瘤复发。最初的上内窥镜检查是正常的,但血管造影术显示造影剂外渗在十二指肠的第一部分,通过线圈栓塞固定,但3周后,另一次出血发生在通过内窥镜血液夹固定的异常附近血管。第三位病人是一位47岁的男性,表现为便血。结肠镜检查显示下行结肠异常血管渗出,经内镜氩等离子体凝固和止血固定。两天后,所有三名患者均接受了内镜超声检查(EUS),结果证实完全止血。结论:胃肠道内窥镜加血管造影术加EUS是更好地管理(诊断、治疗和随访)出血性Dieulafoy病变的有效方法,复发率和死亡率显著降低。
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引用次数: 0
The WHY? of Crohn’s Disease 为什么?克罗恩病
Pub Date : 2018-09-21 DOI: 10.19080/ARGH.2018.10.555798
G. Monif
What is Crohn’s disease? Crohn’s disease is an inflammatory bowel disease in which the wall of one or more segments of the gastrointestinal tract becomes thickened, inflamed and swollen. The thickening may lead to narrowing of the intestine in that area. Patches of Crohn’s disease inflammation may involve only a few centimetres of the intestine or may be much longer, over a metre or more. Any part of the gastrointestinal tract from the mouth to the anus can be affected and there may be more than one area of involvement at one time.
什么是克罗恩病?克罗恩病是一种炎症性肠病,其中胃肠道的一个或多个部分的壁变厚,发炎和肿胀。这种增厚可能导致该区域的肠道变窄。克罗恩病的炎症斑块可能只涉及几厘米的肠道,也可能更长,超过一米或更多。从口腔到肛门的胃肠道的任何部分都可能受到影响,并且可能同时有多个受累区域。
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引用次数: 2
Survey of Dental Health Care Workers Regarding Their Knowledge of Viral Liver Disease and Prevention of Its Transmission, Using an Online Questionnaire 口腔保健人员病毒性肝病知识及预防传播的在线调查问卷
Pub Date : 2018-09-18 DOI: 10.19080/argh.2018.10.555797
Y. Nagao
Background: Over three million people in Japan are estimated to be infected with hepatitis viruses. Dentists need to be aware of measures to prevent transmission and have knowledge of extrahepatic manifestations. However, in Japan, there has been little evaluation of dentists’ knowledge of viral hepatitis. We investigated dental care workers for their knowledge of, and countermeasures against, viral hepatitis. Materials and methods: An anonymous online questionnaire surveying 1,210 members of the Japanese Society of Dental Practice Administration. Interviews were carried out with those who consented. Survey items are attributes, self-management of viral hepatitis, knowledge of liver disease, control of transmission, contacting patients with viral hepatitis, and gathering information on liver diseases. Results: 153 individuals responded to the questionnaire; 41 had not been immunized against hepatitis B and 61 knew of extrahepatic manifestations. Risk and knowledge deficit scores were significantly higher for workers in dental clinics than those in university settings (p<0.001, p=0.014). Conclusion: The respondents had insufficient knowledge of viral hepatitis, a low rate of immunization against hepatitis B and may not follow safe medical practice. It is critical that dentists understand the latest information on hepatitis viruses and acquire knowledge and skills related to medical safety and prevention of infection.
背景:据估计,日本有300多万人感染肝炎病毒。牙医需要了解预防传播的措施,并了解肝外表现。然而,在日本,很少有评估牙医对病毒性肝炎的知识。我们调查了牙科保健工作者对病毒性肝炎的知识和应对措施。材料与方法:采用匿名在线问卷调查方式,对日本牙科执业管理学会1210名会员进行调查。对那些同意的人进行了采访。调查项目为病毒性肝炎的属性、自我管理、肝病知识、传播控制、病毒性肝炎患者接触、肝病信息收集。结果:153人参与问卷调查;41人未接种乙肝疫苗,61人有肝外表现。牙科诊所工作人员的风险和知识缺陷得分显著高于大学工作人员(p<0.001, p=0.014)。结论:调查对象对病毒性肝炎的认识不足,乙型肝炎免疫接种率低,可能不遵循安全的医疗做法。牙医必须了解有关肝炎病毒的最新资讯,并掌握有关医疗安全和预防感染的知识和技能。
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引用次数: 3
期刊
Advanced research in gastroenterology & hepatology
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