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Non-Operative Management of Splenic Injuries (NOMSI) in a Limited Resources Setup 有限资源条件下脾损伤的非手术治疗
Pub Date : 2020-10-02 DOI: 10.19080/ARGH.2020.16.555926
S. Salah
Introduction: Gadarif is an endemic area of medical disorders causing splenomegaly in patients who are also subjected to abdominal trauma. Despite the lack of resources, which make adherence to the international guidelines of NOMSI somehow difficult, we apply it based on clinical evaluation, laboratory tests and ultrasound. Objectives: To study the outcome of NOMSI based on hemodynamic stability, ultrasound findings and follow-up. Methods: A prospective analytic hospital based study conducted in Gadarif, Eastern Sudan from 2015 to 2019, including patients who were having splenic injury with no clear indication for immediate surgery. Results: A total of 30 patients were included, of them 29 (96.7%) were male. Their age ranges between 7-65 years with the mean of 29.8. Twenty patients (66.7%) presented within 24 hours from trauma, while the rest presented later. Three patients (10%) had no history of abdominal trauma, one is an epileptic and the other 2 had concomitant severe malaria. Hemodynamic instability at presentation was found in 14 patients (46.7 %). Left hypochondrial pain was the predominant symptom in 20 patients (66.7 %) and two thirds of patients had tender LHQ. More than half (53.3%) had splenic hematoma/laceration on initial ultrasound. We encountered 5 (16.6%) patients with pathological spleens of Malaria or Visceral Leishmaniasis (Kala-azar). Four patients (13.3%), of those who had increased spleen size on initial US scan, were hemodynamically unstable and required emergency splenectomy resulting in a success rate of NOMSI in 86.7%. Conclusion: NOMSI based on clinical judgment and ultrasound examination in limited resources setup, is feasible and applicable with comparable success rates. Further studies are needed to evaluate NOMSI in endemic areas with pathological spleen.
简介:Gadarif是一种地方性疾病,可导致腹部创伤患者脾肿大。尽管缺乏资源,这使得遵守NOMSI的国际准则有些困难,但我们根据临床评估、实验室检查和超声来应用它。目的:根据血流动力学稳定性、超声表现和随访情况研究NOMSI的预后。方法:2015年至2019年在苏丹东部Gadarif进行了一项前瞻性分析医院研究,包括没有明确指示立即手术的脾损伤患者。结果:共纳入30例患者,其中男性29例,占96.7%。年龄介乎7至65岁,平均29.8岁。20例(66.7%)患者在创伤后24小时内出现,其余患者在创伤后24小时出现。3例(10%)无腹部外伤史,1例为癫痫患者,2例伴有严重疟疾。14例患者(46.7%)出现血流动力学不稳定。20例(66.7%)患者以左肋痛为主要症状,2 / 3患者有压痛性腰痛。超过一半(53.3%)的患者超声表现为脾血肿/撕裂。本院共收治病理性脾型疟疾或内脏利什曼病(黑热病)5例(16.6%)。4例(13.3%)患者在初始US扫描时脾脏增大,血流动力学不稳定,需要紧急脾切除术,导致NOMSI成功率为86.7%。结论:在资源有限的情况下,基于临床判断和超声检查的NOMSI是可行和适用的,成功率相当。在病理性脾流行地区NOMSI的评价有待进一步研究。
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引用次数: 1
Role of Incision Support Using Elastic Abdominal Binders in Reducing Postoperative Pain after Midline Laparotomy: A Randomized Controlled Trial 使用弹性腹部粘合剂的切口支持在减轻中线剖腹产术后疼痛中的作用:一项随机对照试验
Pub Date : 2020-09-15 DOI: 10.19080/ARGH.2020.15.555924
Byshetty Rajendar
Midline laparotomies constitute a majority of intra-abdominal elective and emergency surgical procedures. Midline laparotomy results in postoperative effects on the patient, which include pain with subsequent immobilisation along with decreased pulmonary function and abdominal muscle laxity. Pain is the most incapacitating of all those mentioned, due to its effect on the physical condition and psyche of the patient. Pain after laparotomy is a frequent complication and the prevalence of pain after midline laparotomy is reported as high as 80%. Pain if inadequately treated will cause complications, which can range from short term complications which include hyperglycaemia, increased surgical site infection to long term complications like decreased quality of life and development of chronic pain syndrome [1]. Pain management includes various methods like use of drugs and several newer analgesic/ anaesthetic techniques. One of the simplest and cheapest mechanisms of the many studied and researched is the use of abdominal binders.
中线剖腹产术构成了大多数腹腔内选择性和紧急外科手术。中线剖腹手术会对患者产生术后影响,包括随后固定的疼痛,以及肺功能下降和腹肌松弛。疼痛是上述所有疾病中最令人丧失能力的,因为它会影响患者的身体状况和心理。剖腹术后疼痛是一种常见的并发症,据报道,中线剖腹术后的疼痛发生率高达80%。如果治疗不当,疼痛会导致并发症,包括短期并发症,包括高血糖、手术部位感染增加,以及长期并发症,如生活质量下降和慢性疼痛综合征的发展[1]。疼痛管理包括各种方法,如使用药物和几种较新的镇痛/麻醉技术。在许多研究和研究中,最简单、最便宜的机制之一是使用腹部粘合剂。
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引用次数: 0
Durability of Hbsag Loss During or After Antiviral Treatment and Impact on Clinical Outcome 抗病毒治疗期间或之后Hbsag损失的持久性及其对临床结果的影响
Pub Date : 2020-09-10 DOI: 10.19080/ARGH.2020.15.555923
G. Teuber
Aims: Concerning the durability of HBsAg loss during or after antiviral treatment only a few studies with conflicting results are available indicating a rate of reactivation with reocurrence of HBsAg and/or HBV-DNA in 4.2% 16.4% in predominantly Asian patients. However, there are no larger European studies available concerning the durability of HBsAg loss during or after antiviral treatment and the impact on further clinical outcome. Patients and Methods: In this retrospective German multicentre study, 143 patients with chronic hepatitis B (mean age: 43 ± 13.8 years, 93 males, 50 females) who lost HBsAg during or after antiviral treatment were included. Antiviral treatment with peginterferon-alpha2a (PegIFNalpha2a) and/or nucleus(t)ides were administered between April 2008 and July 2014. Before antiviral treatment, 17 patients had established liver cirrhosis. Primary endpoint was reactivation with reoccurrence of HBsAg Further endpoints were clinical progressive liver disease, liver transplantation and death. Result: During the follow-up period (mean: 3.0 ± 2.1 years) a reoccurrence of HBsAg was observed in only 3/143 patients (2.1%), and in none with previous seroconversion to Anti-HBs. The HBV reactivation in these patients was not associated with detectable HBV-DNA levels, 2/3 patients had baseline cirrhosis and 1/2 subsequently died due to recurrent multifocal hepatocellular carcinoma. Among the 140 patients with persisting HBsAg loss, two initially cirrhotic patients died, and one received liver transplantation all due to hepatocellular carcinoma. Conclusion: In a predominantly Caucasian patient population HBsAg loss during and/or after antiviral treatment seems to be durable with low rates of reactivation. Cirrhotic patients, however, have a high risk developing hepatocellular carcinoma even after HBsAg loss. Continous surveillance in these patients seems to be mandatory.
目的:关于在抗病毒治疗期间或之后HBsAg损失的持久性,只有少数研究结果相互矛盾,表明HBsAg和/或HBV-DNA复发的再激活率为4.2%(16.4%),主要是亚洲患者。然而,目前欧洲还没有更大规模的关于乙肝表面抗原在抗病毒治疗期间或之后损失的持久性以及对进一步临床结果的影响的研究。患者和方法:在这项回顾性的德国多中心研究中,纳入了143例在抗病毒治疗期间或治疗后HBsAg丢失的慢性乙型肝炎患者(平均年龄:43±13.8岁,男性93例,女性50例)。2008年4月至2014年7月期间,使用聚乙二醇干扰素- α 2a (PegIFNalpha2a)和/或核苷进行抗病毒治疗。在抗病毒治疗前,17例患者已建立肝硬化。主要终点是HBsAg再激活,进一步的终点是临床进展性肝病、肝移植和死亡。结果:在随访期间(平均3.0±2.1年),仅有3/143例患者(2.1%)出现HBsAg复发,且无既往血清转化为Anti-HBs的患者。这些患者的HBV再激活与可检测到的HBV- dna水平无关,2/3的患者基线肝硬化,1/2的患者随后死于复发性多灶性肝细胞癌。在140例持续HBsAg丢失的患者中,2例最初肝硬化患者死亡,1例接受肝移植,均因肝细胞癌。结论:在以白人为主的患者群体中,在抗病毒治疗期间和/或之后HBsAg的损失似乎是持久的,再激活率低。然而,肝硬化患者发生肝细胞癌的风险很高,即使在HBsAg消失后也是如此。对这些患者的持续监测似乎是强制性的。
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引用次数: 0
Primary Prophylaxis of Gastric Variceal Bleeding Comparing Cyanoacrylate Injection and Beta-Blockers in Patients with Liver Cirrhosis: A Randomized Controlled Trial 比较氰基丙烯酸酯注射液和受体阻滞剂对肝硬化患者胃静脉曲张出血的初级预防:一项随机对照试验
Pub Date : 2020-09-01 DOI: 10.19080/ARGH.2020.15.555922
G. SalamaA, M. A. Tawfik
Background and study aim: The bleeding from gastric varices are more severe, requiring more blood transfusions, and has a higher mortality rate than esophageal variceal bleeding, there is little data on primary prophylaxis of GV bleeding, we compared the efficacy of cyanoacrylate injection and beta-blockers in primary prophylaxis of gastric variceal bleeding. Methods: Cirrhotics with gastroesophageal varices type 2 with eradicated esophageal varices or large isolated gastric varix type 1, who had never bled from gastric varix, were randomized to cyanoacrylate injection (Group I, n = 30), beta-blockers (Group II, n = 30) or no treatment (Group III, n = 30). Primary endpoints were bleeding from gastric varix or death. Results: bleeding from gastric varices over 6 months follow up was 6.67% in Group I, 20% in Group II, 36.67% in Group III (p = 0.017). GV obliterated or decreased in size 42.86% and 57.14% of group I respectively. No patients neither in group II nor in group III had an obliteration or decrease in GV size. (p < 0.001). Conclusion: Primary prophylaxis in patients with gastric varices is recommended to reduce the risk of first bleeding. Cyanoacrylate injection is more effective than beta-blocker therapy in preventing first gastric variceal bleeding.
背景与研究目的:胃底静脉曲张出血较食管静脉曲张出血更为严重,需要更多的输血,且死亡率更高,关于胃底静脉曲张出血一级预防的资料较少,我们比较了氰基丙烯酸酯注射液与β受体阻滞剂在胃底静脉曲张出血一级预防中的疗效。方法:肝硬化胃食管静脉曲张2型并食管静脉曲张根治或大孤立性胃静脉曲张1型患者,从未因胃静脉曲张出血,随机分为氰基丙烯酸酯注射组(I组,n = 30)、β受体阻滞剂组(II组,n = 30)或不治疗组(III组,n = 30)。主要终点为胃静脉曲张出血或死亡。结果:随访6个月,I组胃底静脉曲张出血率为6.67%,II组为20%,III组为36.67% (p = 0.017)。GV消失或缩小组分别为42.86%和57.14%。II组和III组均无患者出现GV大小闭塞或减小。(p < 0.001)。结论:建议胃静脉曲张患者进行初级预防,以降低首次出血的风险。氰基丙烯酸酯注射液在预防首次胃静脉曲张出血方面比受体阻滞剂治疗更有效。
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引用次数: 1
Hyperferritinemia Has Multifactorial Etiology in Naive Patients with Chronic Hepatitis C 慢性丙型肝炎初发患者高铁蛋白血症有多因素病因
Pub Date : 2020-07-10 DOI: 10.19080/argh.2020.15.555914
Ibrahim Ahmad H. El Bacha, M. Elias, I. Silva, A. Martins, E. Parise
Journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine. Traditionally, elevated serum ferritin is related to the presence of iron accumulation in the body, especially in the liver. However, in chronic hepatitis C several other factors have been alternatively associated with hyperferritinemia, such as liver enzymes, metabolic factors, hepatic steatosis and liver fibrosis. This study aimed to evaluated the exact contribution of these variables to ferritin serum levels in chronic hepatitis.
《临床胃肠病学杂志》是Juniper出版社的一部分,该出版社致力于发表特定主题的文章,重点关注生物学和医学各个领域的个人研究社区的需求。传统上,血清铁蛋白升高与体内,尤其是肝脏中存在铁积聚有关。然而,在慢性丙型肝炎中,其他几个因素也与高铁蛋白血症有关,如肝酶、代谢因子、肝脂肪变性和肝纤维化。本研究旨在评估这些变量对慢性肝炎患者血清铁蛋白水平的确切贡献。
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引用次数: 0
Cholelithiasis: A Brief Review on Diagnostic Approach and Management in Clinical Practice 胆石症:临床诊断方法及治疗综述
Pub Date : 2020-07-07 DOI: 10.19080/argh.2020.15.555913
Febyan, Ruswhandi
Journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine. Cholelithiasis is one of the most prevalent diseases in gastroenterology. There are many factors in cholelithiasis, such as genetic, lack of physical activity, obesity, dietary, age, and other comorbidities. Commonly, cholelithiasis occurs asymptomatically; however, Murphy’s sign is one of the most frequent pathognomonic findings in abdominal examination. Ultrasonography is known as the gold standard imaging examination in diagnosing cholelithiasis. The management of cholelithiasis can be divided into two categories, such as medical treatment and surgical treatment, which depends on the patient’s condition.
《临床胃肠病学杂志》是Juniper出版社的一部分,该出版社致力于发表特定主题的文章,重点关注生物学和医学各个领域的个人研究社区的需求。胆结石是胃肠病中最常见的疾病之一。胆囊结石有许多因素,如遗传、缺乏体育活动、肥胖、饮食、年龄和其他合并症。胆囊结石通常无症状发生;然而,Murphy征是腹部检查中最常见的病理特征之一。超声检查是诊断胆结石的金标准影像学检查。胆结石的治疗可分为两类,如药物治疗和手术治疗,这取决于患者的病情。
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引用次数: 1
Nutritional Status of the Patients with Chronic Liver Disease are More often Overlooked During Clinical Observations 慢性肝病患者的营养状况在临床观察中往往被忽视
Pub Date : 2020-07-02 DOI: 10.19080/argh.2020.15.555912
Guney Merve
Journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine. Current and historical prevalence and mortality data from published sources and international databases show that liver disease is a very important and growing public health problem in European countries [1]. In some parts of Europe, it is estimated that there are more than 1100/10000 cirrhosis and other chronic liver patients.
《临床胃肠病学杂志》是Juniper出版社的一部分,该出版社致力于发表特定主题的文章,重点关注生物学和医学各个领域的个人研究社区的需求。来自已公布来源和国际数据库的当前和历史流行率和死亡率数据表明,肝病是欧洲国家一个非常重要且日益严重的公共卫生问题[1]。据估计,在欧洲的一些地区,有超过1100/10000名肝硬化和其他慢性肝病患者。
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引用次数: 0
Unusual Submucosal Haemotoma in Esophagus on Upper G.I. Endoscopy 上消化道内镜下食管粘膜下异常出血
Pub Date : 2020-06-12 DOI: 10.19080/argh.2020.15.555911
Z. P. Sharma, Ravi C. Sharma, D. Sharma
Journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine. Esophageal submucosal haemotoma is one of the rare disorders of upper gastro intestinal tract and it is considered to be a form of injury to esophagus. There are two types of esophageal injuries: mechanical and chemical injuries. Mechanical injury is subdivided into traumatic and spontaneous ones. Here we present a case of submucosal haemotoma associated with opium intake.
《临床胃肠病学杂志》是Juniper出版社的一部分,该出版社致力于发表特定主题的文章,重点关注生物学和医学各个领域的个人研究社区的需求。食管粘膜下血瘤是上消化道罕见的疾病之一,被认为是食管损伤的一种形式。食道损伤有两种类型:机械损伤和化学损伤。机械性损伤可分为创伤性损伤和自发性损伤。本文报告一例与鸦片摄入有关的黏膜下血瘤。
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引用次数: 0
Reversed Intestinal Rotation with Annular Pancreas Presented as Acute Necrotizing Pancreatitis- A Case report 小肠反向旋转伴环状胰腺表现为急性坏死性胰腺炎1例
Pub Date : 2020-06-08 DOI: 10.19080/argh.2020.15.555909
Byshetty Rajendar
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引用次数: 0
Ulcerative Colitis – Prevention and Treatment with a Plant-Based Diet 溃疡性结肠炎-植物性饮食的预防和治疗
Pub Date : 2020-06-05 DOI: 10.19080/argh.2020.15.555908
A. Strombom
{"title":"Ulcerative Colitis – Prevention and Treatment with a Plant-Based Diet","authors":"A. Strombom","doi":"10.19080/argh.2020.15.555908","DOIUrl":"https://doi.org/10.19080/argh.2020.15.555908","url":null,"abstract":"","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43439935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
Advanced research in gastroenterology & hepatology
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