Pub Date : 2024-11-26eCollection Date: 2024-12-01DOI: 10.1515/almed-2024-0181
Marco Tosi, Davide Negrini, Giovanni Celegon, Martina Montagnana, Giuseppe Lippi
{"title":"Estudio sobre el valor incremental que supone el informe del sedimento en orina en medicina de urgencias mediante el sistema Sysmex<sup>®</sup> Serie-UN.","authors":"Marco Tosi, Davide Negrini, Giovanni Celegon, Martina Montagnana, Giuseppe Lippi","doi":"10.1515/almed-2024-0181","DOIUrl":"10.1515/almed-2024-0181","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"5 4","pages":"381-385"},"PeriodicalIF":1.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-26eCollection Date: 2024-12-01DOI: 10.1515/almed-2024-0182
Erika Jani, Margherita Bozzola, Elmar Marco Zagler, Vincenzo Roccaforte, Massimo Daves
{"title":"Estudio comparativo de un nuevo dispositivo para el análisis de la calidad seminal y la evaluación microscópica manual en un laboratorio clínico no especializado.","authors":"Erika Jani, Margherita Bozzola, Elmar Marco Zagler, Vincenzo Roccaforte, Massimo Daves","doi":"10.1515/almed-2024-0182","DOIUrl":"10.1515/almed-2024-0182","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"5 4","pages":"407-411"},"PeriodicalIF":1.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-25eCollection Date: 2025-03-01DOI: 10.1515/almed-2024-0176
Bernardo Alio Lavin-Gomez, Armando Raúl Guerra Ruíz
{"title":"Considerations about the use of glucometers in glucose tolerance tests.","authors":"Bernardo Alio Lavin-Gomez, Armando Raúl Guerra Ruíz","doi":"10.1515/almed-2024-0176","DOIUrl":"10.1515/almed-2024-0176","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 1","pages":"126-127"},"PeriodicalIF":1.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-21eCollection Date: 2024-12-01DOI: 10.1515/almed-2024-0164
Javier Nieto-Moragas, Anna Marull Arnall, Fernando Calvo Boyero, Salomón Martin Perez, Fernando Marqués García, Javier Hernando Redondo, Albert Blanco Grau, Cristian Cauqui Lende, Ángel Molina Borrás, Daniel Prieto Arribas, Elena de Rafael González
{"title":"Converge of data science and laboratory medicine.","authors":"Javier Nieto-Moragas, Anna Marull Arnall, Fernando Calvo Boyero, Salomón Martin Perez, Fernando Marqués García, Javier Hernando Redondo, Albert Blanco Grau, Cristian Cauqui Lende, Ángel Molina Borrás, Daniel Prieto Arribas, Elena de Rafael González","doi":"10.1515/almed-2024-0164","DOIUrl":"10.1515/almed-2024-0164","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"5 4","pages":"351-352"},"PeriodicalIF":1.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-21eCollection Date: 2025-03-01DOI: 10.1515/almed-2024-0170
Reyes Nicolás de Blas, Miriam Menacho Román, Sara Olivares Romero, Claudia Mesas Mariñán, Alba Arroyo Vega, Graciela Martín Gómez, María Álvarez Pastor, Lucía Castillo Menéndez, María José Azofra Villa, María Del Pilar Pérez Sobrino, Ignacio Arribas Gómez
Objectives: Centrifugation is a key process that should be controlled to ensure an adequate sample quality. To achieve rapid, standardized, and consistent sample centrifugation, we aimed to evaluate an alternative centrifugation protocol and its impact on the results of 20 biochemical determinations in serum.
Methods: The study included 45 ambulatory patients. Two serum-separating tubes were collected from each patient (Becton Dickinson (BD) Vacutainer® SST™ II Advance, 8.5 mL Ref. 366468). One of the tubes was centrifuged at 2,530 × g for 10 min (control method), while the other tube was centrifuged under alternative centrifugation conditions, namely 2,530 × g for 7 min.
Results: The analysis of results revealed that calcium, total bilirubin, and magnesium exhibited a constant and proportional systematic bias. However, considering the proportional mean difference, all analytes met the desirable bias performance established by our laboratory, except for magnesium, which met the minimum bias criteria.
Conclusions: Our study demonstrates that both centrifugation protocols are interchangeable for measuring the studied analytes, thereby ensuring adequate sample quality.
目的：离心是一个关键过程，应加以控制以确保足够的样本质量。为了实现快速、标准化和一致的样本离心，我们旨在评估一种替代离心方案及其对 20 项血清生化测定结果的影响：研究对象包括 45 名门诊患者。每位患者采集两支血清分离管（Becton Dickinson (BD) Vacutainer® SST™ II Advance, 8.5 mL Ref.366468).其中一管在 2,530 × g 下离心 10 分钟（对照方法），另一管在其他离心条件下离心，即 2,530 × g 下离心 7 分钟：结果分析表明，钙、总胆红素和镁的系统偏差恒定且成正比。然而，考虑到比例平均差，除了镁达到了最小偏差标准外，其他分析物都达到了本实验室规定的理想偏差性能：我们的研究表明，两种离心方案在测量所研究的分析物时可以互换，从而确保了足够的样本质量。
{"title":"Evaluation of an alternative centrifugation protocol for reducing total turnaround time.","authors":"Reyes Nicolás de Blas, Miriam Menacho Román, Sara Olivares Romero, Claudia Mesas Mariñán, Alba Arroyo Vega, Graciela Martín Gómez, María Álvarez Pastor, Lucía Castillo Menéndez, María José Azofra Villa, María Del Pilar Pérez Sobrino, Ignacio Arribas Gómez","doi":"10.1515/almed-2024-0170","DOIUrl":"10.1515/almed-2024-0170","url":null,"abstract":"<p><strong>Objectives: </strong>Centrifugation is a key process that should be controlled to ensure an adequate sample quality. To achieve rapid, standardized, and consistent sample centrifugation, we aimed to evaluate an alternative centrifugation protocol and its impact on the results of 20 biochemical determinations in serum.</p><p><strong>Methods: </strong>The study included 45 ambulatory patients. Two serum-separating tubes were collected from each patient (Becton Dickinson (BD) Vacutainer<sup>®</sup> SST™ II Advance, 8.5 mL Ref. 366468)<i>.</i> One of the tubes was centrifuged at 2,530 × <i>g</i> for 10 min (control method), while the other tube was centrifuged under alternative centrifugation conditions, namely 2,530 × <i>g</i> for 7 min.</p><p><strong>Results: </strong>The analysis of results revealed that calcium, total bilirubin, and magnesium exhibited a constant and proportional systematic bias. However, considering the proportional mean difference, all analytes met the desirable bias performance established by our laboratory, except for magnesium, which met the minimum bias criteria.</p><p><strong>Conclusions: </strong>Our study demonstrates that both centrifugation protocols are interchangeable for measuring the studied analytes, thereby ensuring adequate sample quality.</p>","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 1","pages":"108-112"},"PeriodicalIF":1.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18eCollection Date: 2025-03-01DOI: 10.1515/almed-2024-0159
Jorge Sánchez-Cortés, Xavier Gabaldó-Barrios
Objectives: Chanarin-Dorfman syndrome is a rare disease inherited in an autosomal recessive pattern whose prevalence does not exceed 130 cases worldwide.
Case presentation: A 4-year-old patient with generalized erythematous-desquamative ichthyosiform syndrome since birth. The main laboratory finding was persistent hypertransaminasemia. Supplementary studies included peripheral blood smear (PBS), which revealed the presence of multiple cytoplasmatic vacuoles in polymorphonuclear leukocytes (PMN) and platelets. Ichthyosiform lesions concomitant to the presence of lipid vacuoles in peripheral blood PMNs are signs of Chanarin-Dorfman syndrome. Diagnostic suspicion was confirmed by genetic sequencing.
Conclusions: Chanarin-Dorfman syndrome is characterized by a mutation in the CGI-58 gene. This gene is involved in the catabolism of long-chain triglycerides stored in cytoplasmic lipid droplets. Jordans' anomaly is a congenital alteration characterized by the presence of multiple vacuoles in the granulocytic series due to defective lipid metabolism. In this syndrome, long-chain triglycerides build up in tissues, thereby causing dermatological manifestations that are controllable through diet.
{"title":"Jordans' anomaly in Chanarin-Dorfman syndrome.","authors":"Jorge Sánchez-Cortés, Xavier Gabaldó-Barrios","doi":"10.1515/almed-2024-0159","DOIUrl":"10.1515/almed-2024-0159","url":null,"abstract":"<p><strong>Objectives: </strong>Chanarin-Dorfman syndrome is a rare disease inherited in an autosomal recessive pattern whose prevalence does not exceed 130 cases worldwide.</p><p><strong>Case presentation: </strong>A 4-year-old patient with generalized erythematous-desquamative ichthyosiform syndrome since birth. The main laboratory finding was persistent hypertransaminasemia. Supplementary studies included peripheral blood smear (PBS), which revealed the presence of multiple cytoplasmatic vacuoles in polymorphonuclear leukocytes (PMN) and platelets. Ichthyosiform lesions concomitant to the presence of lipid vacuoles in peripheral blood PMNs are signs of Chanarin-Dorfman syndrome. Diagnostic suspicion was confirmed by genetic sequencing.</p><p><strong>Conclusions: </strong>Chanarin-Dorfman syndrome is characterized by a mutation in the <i>CGI-58</i> gene. This gene is involved in the catabolism of long-chain triglycerides stored in cytoplasmic lipid droplets. Jordans' anomaly is a congenital alteration characterized by the presence of multiple vacuoles in the granulocytic series due to defective lipid metabolism. In this syndrome, long-chain triglycerides build up in tissues, thereby causing dermatological manifestations that are controllable through diet.</p>","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 1","pages":"118-121"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18eCollection Date: 2024-12-01DOI: 10.1515/almed-2024-0151
Sarra El Amrani, Bastien Tossens, Louisa Van Belle, Judit Gonda, Sherine Midoun, Christophe Beauloye, Damien Gruson
{"title":"Prueba de cabecera para la valoración de la troponina de alta sensibilidad. Experiencia en el laboratorio clínico de un hospital terciario.","authors":"Sarra El Amrani, Bastien Tossens, Louisa Van Belle, Judit Gonda, Sherine Midoun, Christophe Beauloye, Damien Gruson","doi":"10.1515/almed-2024-0151","DOIUrl":"10.1515/almed-2024-0151","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"5 4","pages":"459-462"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18eCollection Date: 2025-03-01DOI: 10.1515/almed-2024-0148
Estéfani Martínez Chávez, Blanca Fabre-Estremera, Marta Manzano Ocaña, Pilar Fernández-Calle, Antonio Buño Soto, Paloma Oliver
{"title":"Respuesta a la carta al editor: “Consideraciones acerca del uso de glucómetros durante la prueba de tolerancia oral a la glucosa” (https://doi.org/10.1515/almed-2024-0108).","authors":"Estéfani Martínez Chávez, Blanca Fabre-Estremera, Marta Manzano Ocaña, Pilar Fernández-Calle, Antonio Buño Soto, Paloma Oliver","doi":"10.1515/almed-2024-0148","DOIUrl":"10.1515/almed-2024-0148","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 1","pages":"132-134"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-11eCollection Date: 2025-03-01DOI: 10.1515/almed-2024-0119
Reyes Nicolás de Blas, Miriam Menacho Román, Sara Olivares Romero, Claudia Mesas Mariñán, Alba Arroyo Vega, Graciela Martín Gómez, María Álvarez Pastor, Lucía Castillo Menéndez, María José Azofra Villa, María Del Pilar Pérez Sobrino, Ignacio Arribas Gómez
{"title":"Evaluación de un protocolo de centrifugación alternativo que permita reducir el tiempo de respuesta total.","authors":"Reyes Nicolás de Blas, Miriam Menacho Román, Sara Olivares Romero, Claudia Mesas Mariñán, Alba Arroyo Vega, Graciela Martín Gómez, María Álvarez Pastor, Lucía Castillo Menéndez, María José Azofra Villa, María Del Pilar Pérez Sobrino, Ignacio Arribas Gómez","doi":"10.1515/almed-2024-0119","DOIUrl":"10.1515/almed-2024-0119","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 1","pages":"113-117"},"PeriodicalIF":1.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08eCollection Date: 2024-12-01DOI: 10.1515/almed-2024-0133
Javier Nieto-Moragas, Anna Marull Arnall, Fernando Calvo Boyero, Salomón Martin Pérez, Fernando Marqués García, Javier Hernando Redondo, Albert Blanco Grau, Cristian Cauqui Lende, Ángel Molina Borrás, Daniel Prieto Arribas, Elena de Rafael González
{"title":"La convergencia de la ciencia de datos y la medicina de laboratorio.","authors":"Javier Nieto-Moragas, Anna Marull Arnall, Fernando Calvo Boyero, Salomón Martin Pérez, Fernando Marqués García, Javier Hernando Redondo, Albert Blanco Grau, Cristian Cauqui Lende, Ángel Molina Borrás, Daniel Prieto Arribas, Elena de Rafael González","doi":"10.1515/almed-2024-0133","DOIUrl":"10.1515/almed-2024-0133","url":null,"abstract":"","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"5 4","pages":"353-355"},"PeriodicalIF":1.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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