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Health-related quality of life measurements in children and adolescents with refractive errors: A scoping review 屈光不正儿童和青少年的健康相关生活质量测量:范围审查
Pub Date : 2024-03-07 DOI: 10.1016/j.aopr.2024.03.001
Wei Wu , Lisha Yi , Kai Zhang , Zipei Chen , Caiping Shi , Chen Chen , Yilu Cai , Lidan Hu , Xiangjun Chen

Background

Refractive errors, particularly myopia, are the leading visual disorders worldwide, significantly affecting the quality of life (QOL) even after correction. This scoping review focuses on health-related quality of life (HRQOL) measurements for children and adolescents with refractive errors.

Main text

We explored generic and disease-specific HRQOL tools, examining their content, psychometric properties, and the impact of various interventions on QOL. Two English databases—PubMed, Embase, and one Chinese database, CNKI, were searched for relevant studies published from January 2001 to October 2023. Inclusion criteria encompassed studies using standardized instruments to assess the QOL of children aged 0–18 with refractive errors. The review compares prevalent HRQOL measurements, analyzes children's refractive error assessments, and discusses intervention effects on patient QOL.

Conclusions

The study underlines the necessity of developing disease-specific QOL instruments for very young children and serves as a practical guide for researchers in this field. The findings advocate for a targeted approach in HRQOL assessment among the pediatric population, identifying critical gaps in current methodologies.

背景屈光不正,尤其是近视,是全球主要的视觉疾病,即使在矫正后也会严重影响生活质量(QOL)。正文我们探讨了通用的和特定疾病的 HRQOL 工具,研究了它们的内容、心理测量学特性以及各种干预措施对 QOL 的影响。我们在两个英文数据库--PubMed 和 Embase,以及一个中文数据库--CNKI 中检索了 2001 年 1 月至 2023 年 10 月间发表的相关研究。纳入标准包括使用标准化工具评估 0-18 岁屈光不正儿童 QOL 的研究。该综述比较了普遍的 HRQOL 测量方法,分析了儿童屈光不正评估结果,并讨论了对患者 QOL 的干预效果。结论该研究强调了为年幼儿童开发特定疾病 QOL 工具的必要性,并为该领域的研究人员提供了实用指南。研究结果提倡在儿科人群中采用有针对性的方法进行 HRQOL 评估,并指出了当前方法中存在的关键差距。
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引用次数: 0
Personalized treatment concepts in extraocular cancer 眼外癌的个性化治疗理念
Pub Date : 2024-03-01 DOI: 10.1016/j.aopr.2024.02.003
Sitong Ju , Alexander C. Rokohl , Yongwei Guo , Ke Yao , Wanlin Fan , Ludwig M. Heindl

Background

The periocular skin is neoplasms-prone to various benign and malignant. Periocular malignancies are more aggressive and challenging to cure and repair than those in other skin areas. In recent decades, immunotherapy has significantly advanced oncology, allowing the autoimmune system to target and destroy malignant cells. Skin malignancies, especially periocular tumors, are particularly sensitive to immunotherapy. This technique has dramatically impacted the successful treatment of challenging tumors.

Main text

Extraocular cancers, including eyelid (basal cell carcinoma, squamous cell carcinoma, melanoma, merkel cell carcinoma), conjunctival tumors (conjunctival melanoma, ocular surface squamous neoplasia) and other rare tumors, are unique and challenging clinical situations. Several genetic alterations associated with the pathogenesis of these diseases have been identified, and molecular mechanism are essential for the development of the immunotherapy agents, such as Hedgehog pathway inhibitors (vismodegib and sonidegib) for basal cell carcinoma, BRAF/MEK inhibitors (vemurafenib, dabrafenib, and encorafenib) for melanoma, and immune checkpoint inhibitors (Avelumab, pembrolizumab) for Merkel cell carcinoma.

Conclusions

The optimal treatment for periocular skin cancer depends on the type and size of the tumor and whether it involves orbital and adnexal structures. Adjuvant and neoadjuvant therapy with chemotherapy-targeted therapies and immune checkpoint inhibitors should be considered based on tumor type, tumor molecular profile, expected response rate, and candidacy for systemic treatment.

背景眼周皮肤容易发生各种良性和恶性肿瘤。与其他皮肤区域的恶性肿瘤相比,眼周恶性肿瘤更具侵袭性,治愈和修复也更具挑战性。近几十年来,免疫疗法大大推动了肿瘤学的发展,使自身免疫系统能够靶向摧毁恶性细胞。皮肤恶性肿瘤,尤其是眼周肿瘤,对免疫疗法尤为敏感。正文眼外肿瘤,包括眼睑肿瘤(基底细胞癌、鳞状细胞癌、黑色素瘤、梅克尔细胞癌)、结膜肿瘤(结膜黑色素瘤、眼表鳞状细胞瘤)和其他罕见肿瘤,都是独特而具有挑战性的临床病例。目前已发现与这些疾病的发病机制相关的几种基因改变,而分子机制对于免疫疗法药物的开发至关重要,如治疗基底细胞癌的刺猬通路抑制剂(vismodegib 和 sonidegib)、治疗黑色素瘤的 BRAF/MEK 抑制剂(vemurafenib、dabrafenib 和 encorafenib)以及治疗梅克尔细胞癌的免疫检查点抑制剂(Avelumab 和 pembrolizumab)。结论眼周皮肤癌的最佳治疗方法取决于肿瘤的类型和大小,以及是否累及眼眶和附件结构。应根据肿瘤类型、肿瘤分子特征、预期反应率以及是否适合全身治疗等因素,考虑使用化疗靶向疗法和免疫检查点抑制剂进行辅助治疗和新辅助治疗。
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引用次数: 0
Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges 利用干细胞再生治疗眼科疾病:原理、进展与挑战
Pub Date : 2024-02-28 DOI: 10.1016/j.aopr.2024.02.001
Yifei Niu , Junfeng Ji , Ke Yao , Qiuli Fu

Background

Degenerate eye disorders, such as glaucoma, cataracts and age-related macular degeneration (AMD), are prevalent causes of blindness and visual impairment worldwide. Other eye disorders, including limbal stem cell deficiency (LSCD), dry eye diseases (DED), and retinitis pigmentosa (RP), result in symptoms such as ocular discomfort and impaired visual function, significantly impacting quality of life. Traditional therapies are limited, primarily focus on delaying disease progression, while emerging stem cell therapy directly targets ocular tissues, aiming to restore ocular function by reconstructing ocular tissue.

Main text

The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant, owing to the regenerative and malleable properties of stem cells and their functional cells. Currently, stem cell therapy for ophthalmopathy involves various cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and retinal progenitor cells (RPCs). In the current article, we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the retina. These therapies aim to address the loss of functional cells, restore damaged ocular tissue and or in a paracrine-mediated manner. We also provide an overview of the ocular disorders that stem cell therapy is targeting, as well as the difficulties and opportunities in this field.

Conclusions

Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflammation and provide neuroprotection, making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.

背景青光眼、白内障和老年性黄斑变性(AMD)等退行性眼病是全球失明和视力受损的主要原因。其他眼部疾病,包括角膜缘干细胞缺乏症(LSCD)、干眼病(DED)和视网膜色素变性(RP),会导致眼部不适和视觉功能受损等症状,严重影响生活质量。正文由于干细胞及其功能细胞具有再生性和可塑性,利用干细胞治疗各种退行性眼病正变得越来越重要。目前,干细胞治疗眼病涉及多种细胞类型,如胚胎干细胞(ESCs)、诱导多能干细胞(iPSCs)、间充质干细胞(MSCs)和视网膜祖细胞(RPCs)。在本文中,我们将回顾目前利用干细胞再生眼组织的进展,包括从角膜到视网膜的关键眼组织。这些疗法旨在解决功能细胞丧失的问题,恢复受损的眼组织,或以旁分泌介导的方式进行。我们还概述了干细胞疗法针对的眼部疾病,以及该领域的困难和机遇。结论干细胞不仅能促进组织再生,还能释放外泌体减轻炎症和提供神经保护,使干细胞疗法成为通过多种机制治疗各种眼部疾病的有前途的方法。
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引用次数: 0
The use of lens anterior capsule disc for corneal endothelium protection during femtosecond laser-assisted cataract surgery in eyes with low endothelial cell density 在飞秒激光辅助白内障手术中使用晶状体前囊盘保护低内皮细胞密度眼的角膜内皮
Pub Date : 2024-02-28 DOI: 10.1016/j.aopr.2024.02.002
Nina Asrini Noor, Johan Hutauruk, Tjahjono D. Gondhowiardjo
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引用次数: 0
Efficacy of 3% diquafosol combined with azelastine hydrochloride in allergic conjunctivitis patients with dry eye 3% 地卡夫索联合盐酸阿司匹林对过敏性结膜炎干眼症患者的疗效
Pub Date : 2024-02-10 DOI: 10.1016/j.aopr.2024.01.006
Lin Lin , Yirui Zhu , Kelan Yuan, Yujie Mou, Hanhe Zhao, Yayin Wu, Xiuming Jin
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引用次数: 0
Evaluating for unrecognized deficits in perimetry associated with functional upper eyelid malposition 评估与功能性上眼睑位置不正有关的未识别的视力缺陷
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.007
Linyan Wang , Davin C. Ashraf , Michael Deiner , Oluwatobi O. Idowu , Seanna R. Grob , Bryan J. Winn , M Reza Vagefi , Robert C. Kersten

Objective

To investigate whether functional upper eyelid malposition is associated with unrecognized deficits in automated perimetry among glaucoma patients by examining patients undergoing eyelid surgery who had not been identified as requiring eyelid taping during glaucoma field testing.

Methods

In this retrospective pre-post study, an automated database search followed by manual chart review was used to identify eligible patients from January 2012 to March 2020. Included patients had reliable visual field testing within two years before and after functional upper blepharoplasty or ptosis repair and no comorbid ocular diagnoses. As part of routine practice, glaucoma visual field technicians taped patients with pupil-obstructing eyelid malposition; taped examinations were excluded from analysis. Clinical and demographic characteristics, mean deviation, and pattern standard deviation were evaluated within a two year period before and after eyelid surgery.

Results

The final analysis included 60 eyes of 38 patients. Change in visual field parameters after eyelid surgery did not reach statistical significance in crude or adjusted analyses. Among patients with ptosis, the margin reflex distance-1 was not associated with change in mean deviation after surgery (Pearson R2 ​= ​0.0061; P ​= ​0.700). Five of 17 eyes excluded from analysis due to unreliable pre-operative visual fields demonstrated substantial improvement after surgery.

Conclusions

Functional upper eyelid malposition does not appear to cause spurious visual field abnormalities among glaucoma patients with reliable visual fields who were determined not to require eyelid taping at the time of their visual fields. Unreliable visual fields could be a sign of eyelid interference in this population.

目的通过对接受眼睑手术但在青光眼视野测试中未被确认为需要眼睑粘贴的患者进行检查,研究功能性上眼睑位置不正是否与青光眼患者未被发现的自动周边测量缺陷有关。方法在这项事后回顾性研究中,通过自动数据库搜索和人工病历审查来确定 2012 年 1 月至 2020 年 3 月期间符合条件的患者。所纳入的患者在功能性上睑成形术或上睑下垂修复术前后两年内均接受过可靠的视野测试,且无合并眼部诊断。作为常规做法的一部分,青光眼视野技术人员会对瞳孔阻塞性眼睑错位患者进行录音;录音检查不纳入分析。对眼睑手术前后两年内的临床和人口统计学特征、平均偏差和模式标准偏差进行了评估。在粗略分析和调整分析中,双眼皮手术后视野参数的变化均未达到统计学意义。在上睑下垂患者中,边缘反射距离-1与术后平均偏差的变化无关(Pearson R2 = 0.0061;P = 0.700)。在因术前视野不可靠而被排除在分析之外的 17 只眼睛中,有 5 只在术后得到了实质性的改善。结论在视野可靠且在视野检查时被确定不需要眼睑粘贴的青光眼患者中,功能性上眼睑位置不正似乎不会导致假性视野异常。不可靠的视野可能是眼睑干扰这一人群的信号。
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引用次数: 0
Efficacy of 3% diquafosol combined with azelastine hydrochloride in allergic conjunctivitis patients with dry eye 3% 地卡夫索联合盐酸阿司匹林对过敏性结膜炎干眼症患者的疗效
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.006
Lin Lin, Yirui Zhu, Kelan Yuan, Yujie Mou, Hanhe Zhao, Yaying Wu, Xiuming Jin
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引用次数: 0
A two-year longitudinal observational study of the peripapillary microvasculature in pediatric type 1 diabetes mellitus patients without visual impairment or diabetic retinopathy 对无视力障碍或糖尿病视网膜病变的儿童 1 型糖尿病患者毛细血管周围进行为期两年的纵向观察研究
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.001
Lipu Cui, Chenhao Yang, Haidong Zou
{"title":"A two-year longitudinal observational study of the peripapillary microvasculature in pediatric type 1 diabetes mellitus patients without visual impairment or diabetic retinopathy","authors":"Lipu Cui,&nbsp;Chenhao Yang,&nbsp;Haidong Zou","doi":"10.1016/j.aopr.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.aopr.2024.01.001","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667376224000015/pdfft?md5=a4001c50e3181f3eeb005e686e4b871e&pid=1-s2.0-S2667376224000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139674617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOC 技术选择委员会
Pub Date : 2024-02-01 DOI: 10.1016/S2667-3762(24)00015-5
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引用次数: 0
Response to letter to the editor regarding "Is relying on RNFL specific enough to identify any changes in the CNS?" 回复致编辑的信,内容涉及 "依靠 RNFL 的特异性是否足以识别中枢神经系统的任何变化?
Pub Date : 2024-02-01 DOI: 10.1016/j.aopr.2024.01.003
Hanfei Wu , Haishuang Lin , Mengting Ruan, Huanjie Fang, Nannan Dong, Tiewei Wang, Feifei Yu, Jiawei Zhao
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引用次数: 0
期刊
Advances in ophthalmology practice and research
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