Advances in ophthalmology practice and research最新文献_第3页

Complications of high myopia: An update from clinical manifestations to underlying mechanisms 高度近视的并发症：从临床表现到潜在机制的最新进展

Advances in ophthalmology practice and research

Pub Date : 2024-06-21 DOI: 10.1016/j.aopr.2024.06.003

Yu Du , Jiaqi Meng , Wenwen He , Jiao Qi , Yi Lu , Xiangjia Zhu

Background

High myopia is one of the major causes of visual impairment and has an ever-increasing prevalence, especially in East Asia. It is characterized by excessive axial elongation, leading to various blinding complications that extend beyond mere refractive errors and persist immovably after refractive surgery, presenting substantial public health challenge.

Main text

High myopia-related complications include lens pathologies, atrophic and tractional maculopathy, choroidal neovascularization, peripheral retinal degenerations and retinal detachment, and glaucoma and heightened susceptibility to intraocular pressure (IOP) elevation. Pathological lens changes characteristic of high myopia include early cataractogenesis, overgrowth of lens, weakened zonules, and postoperative capsular contraction syndrome, possibly driven by inflammatory pathogenesis, etc. Dome-shaped macula and cilioretinal arteries are two newly identified protective factors for central vision of highly myopic patients. These patients also face risks of open-angle glaucoma and IOP spike following intraocular surgery. Morphologic alternations of optic nerve in high myopia can complicate early glaucoma detection, necessitating comprehensive examinations and close follow-up. Anatomically, thinner trabecular meshwork increases this risk; conversely lamina cribrosa defects may offer a fluid outlet, potentially mitigating the pressure. Notably, anxiety has emerged as the first recognized extra-ocular complication in high myopia, with an underlying inflammatory pathogenesis that connects visual stimulus, blood and brain.

Conclusions

High myopia induces multiple ocular and potential mental health complications, underscoring the need to develop more effective strategies to improve both physical and emotional well-being of these patients, among which anti-inflammation might possibly represent a promising new target.

背景高度近视是视力受损的主要原因之一，其发病率不断上升，尤其是在东亚地区。正文高度近视相关并发症包括晶状体病变、萎缩性和牵引性黄斑病变、脉络膜新生血管、周边视网膜变性和视网膜脱离，以及青光眼和眼压升高。高度近视特有的晶状体病理变化包括早期白内障形成、晶状体过度生长、晶状体带减弱、术后囊膜收缩综合征（可能由炎症致病机制引起）等。穹隆状黄斑和纤支视网膜动脉是新发现的两个保护高度近视患者中心视力的因素。这些患者还面临着开角型青光眼和眼内手术后眼压飙升的风险。高度近视患者视神经的形态变化会使青光眼的早期发现变得复杂，因此需要进行全面检查和密切随访。从解剖学角度看，小梁网变薄会增加这种风险；相反，颅骨板层缺损可能会提供一个液体出口，从而有可能减轻眼压。结论高度近视会诱发多种眼部并发症和潜在的精神健康并发症，因此需要制定更有效的策略来改善这些患者的身体和情绪健康，其中抗炎可能是一个很有前景的新目标。

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引用次数: 0

Animal modeling for myopia 近视动物模型

Advances in ophthalmology practice and research

Pub Date : 2024-06-05 DOI: 10.1016/j.aopr.2024.06.001

Background

Myopia is one of the most common eye diseases globally, and has become an increasingly serious health concern among adolescents. Understanding the factors contributing to the onset of myopia and the strategies to slow its progression is critical to reducing its prevalence.

Main text

Animal models are key to understanding of the etiology of human diseases. Various experimental animal models have been developed to mimic human myopia, including chickens, rhesus monkeys, marmosets, mice, tree shrews, guinea pigs and zebrafish. Studies using these animal models have provided evidences and perspectives on the regulation of eye growth and refractive development. This review summarizes the characteristics of these models, the induction methods, common indicators of myopia in animal models, and recent findings on the pathogenic mechanism of myopia.

Conclusions

Investigations using experimental animal models have provided valuable information and insights into the pathogenic mechanisms of human myopia and its treatment strategies.

背景近视是全球最常见的眼病之一，在青少年中已成为日益严重的健康问题。正文动物模型是了解人类疾病病因的关键。目前已开发出多种模拟人类近视的实验动物模型，包括鸡、恒河猴、狨猴、小鼠、树鼩、豚鼠和斑马鱼。利用这些动物模型进行的研究为调节眼球生长和屈光发育提供了证据和视角。本综述总结了这些模型的特点、诱导方法、动物模型中近视的常见指标以及近视致病机制的最新发现。

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引用次数: 0

Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction 强脉冲光治疗睑板腺功能障碍时不同机器的治疗效果

Advances in ophthalmology practice and research

Pub Date : 2024-06-04 DOI: 10.1016/j.aopr.2024.06.002

Purpose

This study aimed to determine the therapeutic effectiveness of different machines in intense pulsed light (IPL) treatment of meibomian gland dysfunction (MGD).

Methods

213 subjects diagnosed with MGD underwent three sessions of IPL treatment in a control (M22) treatment group or experimental (OPL-I) treatment group and were followed up three to four weeks after each session. Tear breakup time (TBUT), meibomian gland secretion scores (MGSS), meibomian gland meibum scores (MGMS), corneal fluorescein staining (CFS) scores, and the Standard Patient Evaluation of Eye Dryness (SPEED) was used to assess eye dryness signs and symptoms at baseline and follow-up visits.

Results

Two machines had the same working principles except that experimental (OPL-I) group consist of a dual filter system. Both groups showed significant improvements (P < 0.0001) in TBUT, MGSS, MGMS, CFS scores and SPEED scores. Non-inferiority analysis showed no statistically significant differences in any result between the two groups. Various defects appeared on the filter with the extension of usage time. Spectrophotometry showed that light intensity decreased to 93.5% ± 0.46% past the first filter.

Conclusions

IPL treatment completed with different machines have the same effect on improving the symptoms and signs of MGD. The dual filter system in the IPL machine reduces light intensity by approximately 6.5% without affecting its therapeutic effect. It is a feasible measure to ensure double safety and has the significance of popularization not only for MGD but also in other IPL treatment scenarios.

目的本研究旨在确定强脉冲光（IPL）治疗睑板腺功能障碍（MGD）的不同机器的治疗效果。方法 213 名确诊为睑板腺功能障碍的受试者在对照（M22）治疗组或实验（OPL-I）治疗组接受了三次 IPL 治疗，每次治疗后随访三至四周。结果除实验组（OPL-I）采用双滤光片系统外，两台机器的工作原理相同。两组的 TBUT、MGSS、MGMS、CFS 评分和 SPEED 评分均有明显改善（P < 0.0001）。非劣效性分析表明，两组在任何结果上都没有明显的统计学差异。随着使用时间的延长，滤光片上出现了各种缺陷。分光光度法显示，使用第一个滤光器后，光强度下降至 93.5% ± 0.46%。IPL 机中的双滤光系统可将光强度降低约 6.5%，但不会影响其治疗效果。这是确保双重安全的可行措施，不仅对中晚期脱发有推广意义，对其他 IPL 治疗方案也同样适用。

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引用次数: 0

The efficacy of an irrigating eyelid retractor-facilitated ocular rinse on MMP-9 expression and dry eye disease 眼睑牵引器促进眼部冲洗对 MMP-9 表达和干眼症的功效

Advances in ophthalmology practice and research

Pub Date : 2024-05-20 DOI: 10.1016/j.aopr.2024.05.002

Natasha Mayer, Srinivas Sai A. Kondapalli, Nandini Venkateswaran, Hajirah N. Saeed

引用次数: 0

Evaluation and application of a Chinese version symptom questionnaire for visual dysfunctions (CSQVD) in school-age children 中文版学龄儿童视觉功能障碍症状问卷（CSQVD）的评估与应用

Advances in ophthalmology practice and research

Pub Date : 2024-05-11 DOI: 10.1016/j.aopr.2024.05.001

Fuyao Chen, Lixia Lou, Xiaoning Yu, Peike Hu, Weiyi Pan, Xuan Zhang, Xiajing Tang

Objective

To develop and evaluate a Chinese version of the Symptom Questionnaire for Visual Dysfunctions (CSQVD) to quantify visual dysfunction symptoms in school-age children with various eye diseases, and to explore the relationship between ophthalmological disorders and visual dysfunction symptoms.

Methods

Following standard scale adaptation procedures, the Symptom Questionnaire for Visual Dysfunctions (SQVD) was translated into Chinese (CSQVD). We employed random sampling to survey 198 outpatients aged 7–18 to assess the psychometric properties of the CSQVD. Using the reliable and validated questionnaire, we evaluated the determinants of visual dysfunction symptoms among 406 school-age patients at an eye center. The CSQVD scores were correlated with demographic and clinical variables, including gender, age, eye position, refractive power, and best-corrected visual acuity. Univariate analysis identified potential risk factors, followed by binary logistic regression and multiple linear regression analysis on factors with a P-value <0.05.

Results

The CSQVD scale's critical ratio (CR) values ranged from 6.028 to 10.604. The Cronbach's Alpha coefficient was 0.779, and Spearman-Brown split-half reliability was also 0.779. The I-CVI varied from 0.83 to 1.000, the S-CVI/Ave was 0.857, and the KMO value was 0.821. Multifactorial regression analysis indicated that high myopia (OR = 5.744, 95% CI [1.632, 20.218], P = 0.006) and amblyopia (OR = 9.302, 95% CI [1.878, 46.058], P = 0.006) were significant predictors of CSQVD symptoms. Multiple linear regression analysis showed that BCVA of amblyopic eyes (B = −5.052, 95% CI [−7.779, 2.325], P = 0.000) and SE power (B = −0.234, 95% CI [−0.375, 0.205], P = 0.001) significantly affected the CSQVD scale scores.

Conclusions

The Chinese version of the SQVD scale (CSQVD) demonstrates good feasibility, discriminatory power, validity, and reliability in assessing Chinese school-aged children. Furthermore, those who have severe myopia and amblyopia reported more visual dysfunction symptoms.

目的开发和评估中文版视觉功能障碍症状问卷（CSQVD），以量化患有各种眼疾的学龄儿童的视觉功能障碍症状，并探讨眼科疾病与视觉功能障碍症状之间的关系。方法按照标准量表改编程序，将视觉功能障碍症状问卷（SQVD）翻译成中文（CSQVD）。我们采用随机抽样的方法对198名7-18岁的门诊患者进行了调查，以评估CSQVD的心理测量学特性。利用这份可靠且经过验证的问卷，我们评估了眼科中心 406 名学龄儿童视功能障碍症状的决定因素。CSQVD 评分与人口统计学和临床变量（包括性别、年龄、眼位、屈光力和最佳矫正视力）相关。结果CSQVD量表的临界比率（CR）值介于6.028至10.604之间。Cronbach's Alpha 系数为 0.779，Spearman-Brown 分半信度也为 0.779。I-CVI 为 0.83 至 1.000，S-CVI/Ave 为 0.857，KMO 值为 0.821。多因素回归分析表明，高度近视（OR = 5.744，95% CI [1.632，20.218]，P = 0.006）和弱视（OR = 9.302，95% CI [1.878，46.058]，P = 0.006）是 CSQVD 症状的重要预测因素。多元线性回归分析显示，弱视眼的BCVA（B = -5.052，95% CI [-7.779, 2.325]，P = 0.000）和SE功率（B = -0.234，95% CI [-0.375, 0.205]，P = 0.001）对CSQVD量表评分有显著影响。此外，重度近视和弱视儿童报告的视功能障碍症状更多。

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引用次数: 0

TOC 技术选择委员会

Advances in ophthalmology practice and research

Pub Date : 2024-05-01 DOI: 10.1016/S2667-3762(24)00030-1

引用次数: 0

Association between glaucoma and stroke: A bidirectional mendelian randomization study 青光眼与中风之间的关系：双向孟德尔随机研究

Advances in ophthalmology practice and research

Pub Date : 2024-04-23 DOI: 10.1016/j.aopr.2024.04.003

Kai Wang , Xueqi Lin , Siting Sheng , Dan Chen , Xin Liu , Ke Yao

Purpose

Observational studies have reported positive associations between glaucoma and stroke; however, controversial results exist. Importantly, the nature of the relationship remains unknown since previous studies were not designed to test causality. Therefore, we aimed to investigate the possible causal relationships between glaucoma and stroke.

Methods

Our two-sample Mendelian randomization (MR) encompassed multi-ethnic large-scale genome-wide association studies with more than 20000 cases and 260000 controls for glaucoma, and more than 80000 cases and 630000 controls for stroke. Individual effect estimates for each SNP were combined using the inverse-variance weighted (IVW) method. To avoid potential pleiotropic effects, we adjusted the main results by excluding genetic variants associated with metabolic factors. The weighted median and MR-Egger methods were also used for the sensitivity analysis.

Results

Our MR analysis revealed that glaucoma and its subtypes, including primary open-angle glaucoma and primary angle-closure glaucoma, exhibited no causal role in relation to any stroke (AS), any ischemic stroke (AIS), large-artery atherosclerotic stroke (LAS), small-vessel stroke (SVS), or cardioembolic stroke (CES) across MR analyses (all P > 0.05). The null associations remained robust even after adjusting for metabolic-related traits and were consistent in both the European and Asian populations. Furthermore, reverse MR analyses also did not indicate any significant causal effects of AS, AIS, LAS, or CES on glaucoma risk.

Conclusions

Evidence from our series of causal inference approaches using large-scale population-based MR analyses did not support causal effects between glaucoma and stroke. These findings suggest that the relationship of glaucoma management and stroke risk prevention should be carefully evaluated in future studies. In turn, stroke diagnosis should not be simply applied to glaucoma risk prediction.

目的观察性研究报告了青光眼与中风之间的正相关关系，但结果存在争议。重要的是，由于以前的研究并不是为了检验因果关系而设计的，因此这种关系的性质仍然未知。因此，我们旨在研究青光眼与中风之间可能存在的因果关系。方法我们的双样本孟德尔随机化（MR）研究涵盖了多种族的大规模全基因组关联研究，其中青光眼有超过 20000 个病例和 260000 个对照，中风有超过 80000 个病例和 630000 个对照。采用逆方差加权法（IVW）合并了每个 SNP 的单个效应估计值。为避免潜在的多向效应，我们排除了与代谢因素相关的遗传变异，对主要结果进行了调整。结果我们的 MR 分析显示，在所有 MR 分析中，青光眼及其亚型（包括原发性开角型青光眼和原发性闭角型青光眼）与任何中风（AS）、任何缺血性中风（AIS）、大动脉粥样硬化性中风（LAS）、小血管中风（SVS）或心肌栓塞性中风（CES）均无因果关系（所有 P 均为 0.05）。即使在调整了代谢相关特征后，这种无效关联仍然很强，而且在欧洲和亚洲人群中都是一致的。此外，反向 MR 分析也未显示 AS、AIS、LAS 或 CES 对青光眼风险有任何显著的因果效应。这些发现表明，在未来的研究中应仔细评估青光眼管理与中风风险预防之间的关系。反过来，中风诊断也不应简单地应用于青光眼风险预测。

{"title":"Association between glaucoma and stroke: A bidirectional mendelian randomization study","authors":"Kai Wang , Xueqi Lin , Siting Sheng , Dan Chen , Xin Liu , Ke Yao","doi":"10.1016/j.aopr.2024.04.003","DOIUrl":"10.1016/j.aopr.2024.04.003","url":null,"abstract":"<div><h3>Purpose</h3><p>Observational studies have reported positive associations between glaucoma and stroke; however, controversial results exist. Importantly, the nature of the relationship remains unknown since previous studies were not designed to test causality. Therefore, we aimed to investigate the possible causal relationships between glaucoma and stroke.</p></div><div><h3>Methods</h3><p>Our two-sample Mendelian randomization (MR) encompassed multi-ethnic large-scale genome-wide association studies with more than 20000 cases and 260000 controls for glaucoma, and more than 80000 cases and 630000 controls for stroke. Individual effect estimates for each SNP were combined using the inverse-variance weighted (IVW) method. To avoid potential pleiotropic effects, we adjusted the main results by excluding genetic variants associated with metabolic factors. The weighted median and MR-Egger methods were also used for the sensitivity analysis.</p></div><div><h3>Results</h3><p>Our MR analysis revealed that glaucoma and its subtypes, including primary open-angle glaucoma and primary angle-closure glaucoma, exhibited no causal role in relation to any stroke (AS), any ischemic stroke (AIS), large-artery atherosclerotic stroke (LAS), small-vessel stroke (SVS), or cardioembolic stroke (CES) across MR analyses (all <em>P</em> > 0.05). The null associations remained robust even after adjusting for metabolic-related traits and were consistent in both the European and Asian populations. Furthermore, reverse MR analyses also did not indicate any significant causal effects of AS, AIS, LAS, or CES on glaucoma risk.</p></div><div><h3>Conclusions</h3><p>Evidence from our series of causal inference approaches using large-scale population-based MR analyses did not support causal effects between glaucoma and stroke. These findings suggest that the relationship of glaucoma management and stroke risk prevention should be carefully evaluated in future studies. In turn, stroke diagnosis should not be simply applied to glaucoma risk prediction.</p></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"4 3","pages":"Pages 147-155"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266737622400026X/pdfft?md5=f5822fa1d44ff49b6f4b0d75f5a86be2&pid=1-s2.0-S266737622400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalized treatment approaches in intraocular cancer 眼内癌的个性化治疗方法

Advances in ophthalmology practice and research

Pub Date : 2024-04-13 DOI: 10.1016/j.aopr.2024.03.005

Yating Liu , Alexander C. Rokohl , Yongwei Guo , Ke Yao , Wanlin Fan , Ludwig M. Heindl

Background

Intraocular malignant tumors represent a severe disease that threatens vision as well as life. To better extend the life of the patient, preserve visual function, and maintain ocular aesthetics, selecting the appropriate timing and methods of treatment becomes crucial.

Main text

With the continuous advancement of medical technology, the techniques and methods for treating intraocular malignant tumors are constantly evolving. While surgery was once considered the optimal method to prolong patient survival and prevent local recurrence, the discovery and application of various treatments such as radiotherapy, laser therapy, chemotherapy, cryotherapy, and monoclonal antibodies have led to a greater diversity of treatment options. This diversity offers more possibilities to develop personalized treatment plans, and thereby maximize patient benefit. This article reviews the various treatment methods for intraocular malignant tumors, including indications for treatment, outcomes, and potential complications.

Conclusions

Differentiating small intraocular malignant tumors from pigmented lesions is challenging, and ongoing monitoring with regular follow-up is required. Small to medium-sized tumors can be treated with radiotherapy combined with transpupillary thermotherapy. Depending on the tumor's distance from the optic disc, surgery with partial resection may be considered for distant tumors, while proximal tumors may require complete enucleation. Systemic chemotherapy has been widely applied to patients with retinal tumors, lymphomas, and intraocular metastatic cancers, but has limited efficacy in patients with choroidal melanoma. Antagonists of Vascular Endothelial Growth Factor (Anti-VEGF) drugs can improve patient vision and quality of life, while the efficacy of immunotherapy and molecular targeted therapy is still under research.

背景眼内恶性肿瘤是一种严重威胁视力和生命的疾病。正文随着医疗技术的不断进步，治疗眼内恶性肿瘤的技术和方法也在不断发展。手术曾被认为是延长患者生存期和防止局部复发的最佳方法，而放疗、激光治疗、化疗、冷冻治疗和单克隆抗体等各种治疗方法的发现和应用，使治疗方案更加多样化。这种多样性为制定个性化治疗方案提供了更多可能性，从而使患者受益最大化。本文回顾了眼内恶性肿瘤的各种治疗方法，包括治疗适应症、疗效和潜在并发症。结论将眼内小恶性肿瘤与色素性病变区分开来具有挑战性，需要定期随访进行持续监测。中小型肿瘤可采用放疗结合经瞳孔热疗的方法进行治疗。根据肿瘤与视盘的距离，远处的肿瘤可考虑手术部分切除，而近处的肿瘤可能需要完全去核。全身化疗已广泛应用于视网膜肿瘤、淋巴瘤和眼内转移性癌症患者，但对脉络膜黑色素瘤患者的疗效有限。血管内皮生长因子拮抗剂（Anti-VEGF）可改善患者的视力和生活质量，而免疫疗法和分子靶向疗法的疗效仍在研究中。

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引用次数: 0

Global incidence and prevalence of malignant orbital tumors 全球恶性眼眶肿瘤的发病率和流行率

Advances in ophthalmology practice and research

Pub Date : 2024-04-13 DOI: 10.1016/j.aopr.2024.04.002

Weina Zhang , Alexander C. Rokohl , Yongwei Guo , Ke Yao , Wanlin Fan , Ludwig M. Heindl

Purpose

Aims to provide an overview of the contemporary epidemiology of malignant orbital tumors by analyzing population-based incidence patterns across various regions worldwide.

Methods

In this article, we retrieved orbital malignancy data from the MEDLINE database and analyzed the incidence and prevalence of orbital malignancies worldwide. We performed the literature search by searching on the Mesh terms for malignant orbital tumors ("orbital", "tumor", "lymphoma", "malignant", "cancer", "incidence", and "epidemiology"). All included studies were published between 1993 and 2023 and were written in English.

Results

Ocular or ophthalmic lymphoma most frequently occurred in the orbit, with a prevalence ranging from 47% to 54%. The incidence of malignant orbital tumors was increasing in the USA (2.0 per million (1981–1993), Netherlands (0.86 (1981–1985) to 2.49 (2001–2005) per million) and South Korea (0.3–0.8 per million (1999–2016)), respectively. Ophthalmic lymphoma which includes orbit lymphoma was increasing in Canada (0.17–1.47 per million (1992–2010)), Denmark (0.86 per million (1981–1985) to 2.49 per million (2001–2005)), respectively.

Conclusions

The predominant primary malignant orbital tumor in adults was lymphoma. Ocular or ophthalmic lymphoma most frequently occured in the orbit. The limited data available suggested an increasing trend in the incidence of malignant orbital tumors in each country included, which were mainly attributed to the increase in lymphoma. Generally, incidence rates were found to increase with advancing age, with no difference between males and females.

目的通过分析全球不同地区基于人群的发病模式，概述当代眼眶恶性肿瘤的流行病学。方法本文从 MEDLINE 数据库中检索眼眶恶性肿瘤数据，分析全球眼眶恶性肿瘤的发病率和流行率。我们以眼眶恶性肿瘤的 Mesh 关键词（"眼眶"、"肿瘤"、"淋巴瘤"、"恶性"、"癌症"、"发病率 "和 "流行病学"）进行文献检索。结果眼眶或眼部淋巴瘤最常发生在眼眶，发病率为 47% 至 54%。美国（1981-1993年）、荷兰（1981-1985年）和韩国（2001-2005年）的恶性眼眶肿瘤发病率分别为每百万人2.0例、每百万人0.86例和每百万人2.49例，1999-2016年为每百万人0.3-0.8例。包括眼眶淋巴瘤在内的眼眶淋巴瘤在加拿大（每百万人中有0.17-1.47例（1992-2010年））、丹麦（每百万人中有0.86例（1981-1985年）至2.49例（2001-2005年））分别呈上升趋势。眼部或眼眶淋巴瘤最常发生在眼眶。现有的有限数据表明，每个国家的恶性眼眶肿瘤发病率都呈上升趋势，这主要归因于淋巴瘤的增加。一般来说，发病率随着年龄的增长而增加，男女之间没有差异。

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引用次数: 0

Advances in ophthalmology practice and research

Pub Date : 2024-04-05 DOI: 10.1016/j.aopr.2024.04.001

Xiaojun Ju , Alexander C. Rokohl , Xueting Li , Yongwei Guo , Ke Yao , Wanlin Fan , Ludwig M. Heindl

Purpose

To explore the role of ultraviolet radiation (UVR) in the occurrence and development of various ocular malignancies.

Methods

In this article, we retrieved ocular malignancy data from the Global Cancer Observatory (GCO) and performed correlation analysis with the global UV index and sunshine duration. We searched for associated studies using the following databases: Embase, Pubmed, Cochrane Library, and Google Scholar. We conducted the literature by searching the Mesh terms denoting an exposure of interest ("UV radiation", "ultraviolet rays", and "ocular malignancies", All studies included are published until December 30, 2023 without language restrictions.

Results

The mechanisms and epidemiological statistics of UVR on the onset and progression of eyelid malignancies are the most studied and clear. The role of UVR in conjunctival melanoma is similar to that in eyelid melanoma. The relationship between uveal melanoma and UVR is controversial, however, it may have at least a certain impact on its prognosis. UVR causes ocular surface squamous neoplasia by further activating HPV infection.

Conclusions

UVR is a decisive risk factor for ocular malignancies, but the incidence of ultraviolet-induced tumors is also affected by many other factors. A correct and comprehensive understanding of the mechanisms of UVR in the pathogenesis of ocular malignant tumors can provide patients with more effective and selective immune regulation strategies.

目的探讨紫外线辐射（UVR）在各种眼部恶性肿瘤的发生和发展中的作用。方法本文检索了全球癌症观测站（GCO）的眼部恶性肿瘤数据，并对全球紫外线指数和日照时间进行了相关分析。我们使用以下数据库搜索相关研究：Embase、Pubmed、Cochrane Library 和 Google Scholar。结果紫外线对眼睑恶性肿瘤发病和进展的机制和流行病学统计是研究得最清楚、最明确的。紫外线辐射在结膜黑色素瘤中的作用与眼睑黑色素瘤相似。葡萄膜黑色素瘤与紫外线辐射之间的关系尚存争议，但至少可能对其预后有一定影响。结论紫外线辐射是眼部恶性肿瘤的决定性危险因素，但紫外线诱发肿瘤的发病率还受到许多其他因素的影响。正确、全面地认识紫外线辐射在眼部恶性肿瘤发病机制中的作用，可以为患者提供更有效、更有选择性的免疫调节策略。

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引用次数: 0