Advances in ophthalmology practice and research最新文献

{"title":"Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study)","authors":"Adriano Cypriano Faneli ,&nbsp;Ricardo Danilo Chagas Oliveira ,&nbsp;Pablo Amado ,&nbsp;Eduardo F. Marback ,&nbsp;Rodrigo Amaral Torres ,&nbsp;Juliana Fernandes Marback ,&nbsp;Larrie Laporte ,&nbsp;Caio Vinicius Saito Regatieri ,&nbsp;Cristina Muccioli","doi":"10.1016/j.aopr.2025.04.001","DOIUrl":"10.1016/j.aopr.2025.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Topical anesthesia for cataract surgery often requires adjunctive sedation to manage intraoperative discomfort and improve patient cooperation. Ketamine and fentanyl, combined with benzodiazepines, are commonly used sedation regimens, but their comparative safety and efficacy in the cataract surgery context remain underexplored. This study aimed to evaluate whether ketamine combined with midazolam is non-inferior to fentanyl combined with midazolam for sedation during phacoemulsification, with a non-inferiority margin of 10%.</div></div><div><h3>Methods</h3><div>This prospective, double-blind, crossover, non-inferiority trial randomized 75 patients to receive both sedation regimens for bilateral phacoemulsification. A 15-day washout period was implemented between surgeries. Adequate sedation was defined as a Ramsay Sedation Scale score of 2–3. The primary outcome was sedation adequacy, with secondary outcomes including patient and surgeon satisfaction, surgical metrics, and complications.</div></div><div><h3>Results</h3><div>Of the 75 randomized patients, 65 (130 eyes) completed the study. Adequate sedation was achieved in 86.2% of cases with ketamine and 89.2% with fentanyl, with a within-participant difference of 3.1% (95% CI: −2.3%–5.3%), confirming non-inferiority. Patient satisfaction scores were similarly high between regimens (ketamine: 4.87 ​± ​0.36; fentanyl: 4.91 ​± ​0.28; <em>P</em> ​= ​0.45). Complications were infrequent, with two cases of nausea and two of bradycardia in the fentanyl group and one case of nausea and two of hypertension in the ketamine group.</div></div><div><h3>Conclusions</h3><div>Ketamine combined with midazolam is a safe and effective alternative to fentanyl-based sedation for cataract surgery, providing comparable sedation quality and satisfaction. These findings support ketamine's use in cataract surgery.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 3","pages":"Pages 175-179"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of risk prediction models for different subtypes of retinal vein occlusion","authors":"Chunlan Liang ,&nbsp;Lian Liu ,&nbsp;Wenjuan Yu ,&nbsp;Qi Shi ,&nbsp;Jiang Zheng ,&nbsp;Jun Lyu ,&nbsp;Jingxiang Zhong","doi":"10.1016/j.aopr.2025.03.003","DOIUrl":"10.1016/j.aopr.2025.03.003","url":null,"abstract":"<div><h3>Purpose</h3><div>While prognostic models for retinal vein occlusion (RVO) exist, subtype-specific risk prediction tools for central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) remain limited. This study aimed to construct and validate distinct CRVO and BRVO risk stratification nomograms.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed electronic medical records from a tertiary hospital in Guangzhou (January 2010–November 2024). Non-RVO controls were matched 1:4 (CRVO) and 1:2 (BRVO) by sex and year of admission. The final cohorts included 630 patients (126 CRVO cases and 504 controls) and 813 patients (271 BRVO cases and 542 controls). Predictors encompassed clinical histories and laboratory indices. Multivariate regression identified independent risk factors, and model performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis (DCA).</div></div><div><h3>Results</h3><div>The CRVO-nom and BRVO-nom highlighted significant predictors, including the neutrophil-to-lymphocyte ratio (NLR). Additional risk factors for CRVO included high-density lipoprotein cholesterol (HDL-C), platelet distribution width (PDW), history of diabetes, cerebral infarction, and coronary artery disease (CAD). For BRVO, significant predictors included a history of hypertension, age, and body mass index (BMI). The AUC for CRVO-nom was 0.80 (95% CI: 0.73–0.87) in the training set and 0.77 (95% CI: 0.65–0.86) in the validation set, while BRVO-nom yielded an AUC of 0.95 (95 ​%CI: 0.91–0.97) in the training set and 0.95 (95% CI: 0.89–0.98) in the validation set.</div></div><div><h3>Conclusions</h3><div>CRVO and BRVO exhibit distinct risk profiles. The developed nomograms—CRVO-nom and BRVO-nom—provide subtype-specific risk stratification with robust discrimination and clinical applicability. An online Shiny calculator facilitates real-time risk estimation, enabling targeted prevention for high-risk populations.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 107-116"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of intraocular pressure fluctuations on the progression of glaucoma and associated factors","authors":"Tong Liu ,&nbsp;YiLu Cai ,&nbsp;MengYuan Hu ,&nbsp;Zongrong Wang ,&nbsp;Xin Liu ,&nbsp;Min Chen ,&nbsp;Kaijun Wang","doi":"10.1016/j.aopr.2025.03.002","DOIUrl":"10.1016/j.aopr.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, remarkable advancements in the comprehension of glaucoma pathophysiology have highlighted the necessity of looking beyond the conventional focus on mean intraocular pressure (IOP) levels. IOP fluctuations have been identified as a potential factor that could exert a substantial impact on the progression of glaucoma.</div></div><div><h3>Main text</h3><div>IOP exhibits dynamic variations throughout a 24-h cycle. Glaucoma patients exhibit substantially more pronounced IOP fluctuations compared to healthy individuals, even when the mean IOP remains within the normal range. This implies that IOP fluctuations may play a role in glaucoma progression through mechanisms independent of elevated mean IOP. In this review, an exhaustive examination of studies spanning the past decade was conducted to analyze the relationship between IOP fluctuations and disease progression in primary open-angle glaucoma (POAG), ocular hypertension (OHT), normal tension glaucoma (NTG), and primary angle-closure glaucoma (PACG). While a few studies present conflicting results, the majority of research supports the notion that elevated IOP fluctuations significantly contribute to disease progression in POAG patients. This association has also been confirmed in PACG patients. However, in NTG or OHT patients, other risk factors may outweigh IOP fluctuations in disease progression or glaucoma conversion. Additionally, we summarized common factors affecting IOP fluctuations to provide a basis for the identification of patients prone to significant daily IOP variations. Finally, the efficacy of various IOP-lowering interventions in modulating IOP fluctuations is concisely summarized, offering insights for the formulation of comprehensive treatment strategies that incorporate IOP fluctuation management.</div></div><div><h3>Conclusions</h3><div>IOP fluctuations play a significant role in disease progression in POAG and PACG. Individuals with certain systemic or ocular characteristics are more predisposed to pronounced and recurrent IOP fluctuations. Consequently, a comprehensive assessment of IOP fluctuation that transcends mean IOP values, as well as the integration of IOP fluctuations management into glaucoma treatment strategies are of paramount importance.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 142-148"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a specific vitamin supplement containing L-methylfolate (Ocufolin forte) in patients with neovascular age-related macular degeneration","authors":"Tatjana Josifova ,&nbsp;Katarzyna Konieczka ,&nbsp;Andreas Schötzau ,&nbsp;Josef Flammer","doi":"10.1016/j.aopr.2025.03.001","DOIUrl":"10.1016/j.aopr.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Patients with nAMD often have pathologically elevated homocysteine (Hcy) and increased retinal venous pressure (RVP). We tested whether the administration of a specific vitamin preparation containing L-methylfolate (Ocufolin forte) as an addition to anti-VEGF therapy reduces these two risk factors and favorably influences the disease course.</div></div><div><h3>Methods</h3><div>A total of 27 eyes/27 patients with intra- and subretinal fluid, Hcy above 12 ​μmol/L, RVP of at least 8 ​mm above the IOP, and an IOP between 10 and 20 ​mmHg were included in this study. All eyes received three injections of 0.05 ​ml aflibercept at one-month intervals as clinically indicated. Fifteen patients additionally received one capsule of Ocufolin forte per day (Ocufolin group, OG), and the other twelve patients served as a control group (control group, CG). The following factors were measured before therapy and four months later: blood Hcy, best-corrected visual acuity (BCVA), intra-ocular pressure (IOP), RVP, optical coherence tomography (OCT), and optical coherence tomography - angiography (OCTA).</div></div><div><h3>Results</h3><div>Hcy decreased on average by 5.58 ​μmol/L in the OG and by 0.57 ​μmol/L in the CG. The RVP decreased on average by 4.60 ​mmHg in the OG and by 0.75 ​mmHg in the CG. The difference between the two groups was significant for both parameters (<em>P</em> ​&lt;0.001); 66% of the OG and 41% of the CG had no retinal fluid at the end of the study. After the completion of the study, the injection intervals could be extended more often in the OG patients than in the CG patients.</div></div><div><h3>Conclusions</h3><div>When Ocufolin forte was added to the standard therapy, RVP and Hcy were reduced to a significantly greater extent than without Ocufolin forte. In addition, Ocufolin had a positive influence on morphology and future treatment intervals with anti-VEGF therapy.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 135-141"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mild posterior capsule opacification on visual outcomes in trifocal diffractive pseudophakic eyes: A multicenter prospective study","authors":"Limei Zhang ,&nbsp;Runhan Shi ,&nbsp;Xuanzhu Chen ,&nbsp;Xuefen Gu ,&nbsp;Jiying Shen ,&nbsp;Aijun Wang ,&nbsp;Shuang Ni ,&nbsp;Lei Cai ,&nbsp;Haike Guo ,&nbsp;Jin Yang","doi":"10.1016/j.aopr.2025.02.002","DOIUrl":"10.1016/j.aopr.2025.02.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To elucidate the impact of mild PCO on the visual outcomes in patients with hydrophilic trifocal IOLs, and to identify objective indicators that can assist in determining the need for Nd:YAG laser capsulotomy.</div></div><div><h3>Methods</h3><div>This is a prospective observational study. 189 patients implanted trifocal IOL who underwent Nd:YAG laser posterior capsulotomy were recruited. Patients were classified into four grades according to PCO morphology. The distance, intermediate, and near visual acuity (VA), dysfunction lens index (DLI), contrast sensitivity (CS) and visual function (VF-14) scores were measured before and 1 month after Nd:YAG laser capsulotomy.</div></div><div><h3>Results</h3><div>Before Nd:YAG laser capsulotomy, a significant correlation was observed between PCO grading and uncorrected distance (UDVA), intermediate (UIVA), near (UNVA) visual acuity, corrected distance VA (CDVA), DLI, and VF-14 scores (All <em>P</em> ​&lt; ​0.001). However, in patients with PCO grade 1 (mild), post-capsulotomy UNVA, DLI, medium and high spatial frequency CS under photopic condition and VF-14 scores were significantly improved compared with pre-capsulotomy values (all <em>P</em> ​&lt; ​0.05). The area under the receiver operating characteristic curve for DLI was 0.830 (<em>P</em> ​&lt; ​0.001), with a corresponding cut-off value of 7.225, indicating its usefulness in assessing the need for Nd:YAG laser capsulotomy in cases of mild PCO.</div></div><div><h3>Conclusions</h3><div>Mild PCO initially impairs near visual acuity in patients with trifocal IOLs and concurrently diminishes both subjective and objective of visual quality. The DLI can serve as an auxiliary diagnostic indicator to assess whether patients with mild PCO may benefit from Nd:YAG laser capsulotomy.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 117-123"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of tear film stability on corneal refractive power measurement and surgical planning for cataract","authors":"Yuanfeng Jiang ,&nbsp;Xiteng Chen ,&nbsp;Yichen Gao,&nbsp;Nan Gao,&nbsp;Huiyu Wang,&nbsp;Yanwen Feng,&nbsp;Meisa Li,&nbsp;Luning Qin,&nbsp;Fei Li,&nbsp;Shaozhen Zhao,&nbsp;Shaochong Bu,&nbsp;Fang Tian","doi":"10.1016/j.aopr.2025.02.001","DOIUrl":"10.1016/j.aopr.2025.02.001","url":null,"abstract":"<div><h3>Purpose</h3><div>This prospective cohort study aimed to assess the influence of tear film stability on corneal refractive power measurement and surgical planning in cataract patients.</div></div><div><h3>Methods</h3><div>Participants were divided into tear film instability (tear film stability level 2) and control (level 0–1) groups based on Keratograph 5M results. Using IOL Master 700, two consecutive measurements were obtained with a 10-min interval. Parameters including standard keratometry (Kf, Ks and K), keratometric corneal astigmatism (KCA), total keratometry (TKf, TKs and TK) and total corneal astigmatism (TCA) were recorded. IOL power was calculated using SRK-T, SRK-T TK, Haigis, Haigis TK, Barrett Universal II, and Barrett Universal II TK formulas.</div></div><div><h3>Results</h3><div>The results showed significantly higher differences between two measurements in Kf, K, KCA, TKf, TK, and TCA, as well as the vector variability of corneal astigmatism in the tear film instability group (all <em>P</em> ​&lt; ​0.05). Of all formulas, only the SRK-T formula displayed significantly higher variability in IOL power calculations in the tear film instability group compared to the control group (<em>P</em> ​&lt; ​0.05).</div></div><div><h3>Conclusions</h3><div>This study highlights that tear film instability can lead to deviations in corneal refractive power and astigmatism measurements, contributing to increased prediction errors in IOL power calculation, particularly with the SRK-T formula.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 100-106"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alterations of ocular surface metabolism and the related immunity inflammation in dry eye","authors":"Xiaojie Wan ,&nbsp;Yu Zhang ,&nbsp;Kaiye Zhang ,&nbsp;Yujie Mou ,&nbsp;Xiuming Jin ,&nbsp;Xiaodan Huang","doi":"10.1016/j.aopr.2024.08.003","DOIUrl":"10.1016/j.aopr.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><div>Dry eye disease (DED) stands as a prominent ocular condition of global prevalence, emerging as a growing concern within public health. However, the underlying mechanisms involved in its pathogenesis remain largely unknown. In recent years, with the development of metabolomics, numerous studies have reported alterations in ocular surface metabolism in DED and offered fresh perspectives on the development of DED.</div></div><div><h3>Main text</h3><div>The metabolic changes of the ocular surface of DED patients are closely intertwined with the cellular metabolism process and immune inflammation changes. This article expounds upon the correlation between ocular surface metabolism and immune inflammation alterations in DED in terms of glycolysis, lipid metabolism, amino acid metabolism, cellular signaling pathways, and immune inflammation regulation.</div></div><div><h3>Conclusions</h3><div>The alterations in ocular surface metabolism of patients with dry eye are closely associated with their inflammatory status. Our work contributes novel insights into the pathogenesis of dry eye diseases and offers innovative molecular targets for diagnosing, detecting, and managing DED patients.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOC","authors":"","doi":"10.1016/S2667-3762(25)00008-3","DOIUrl":"10.1016/S2667-3762(25)00008-3","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages iii-iv"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between myopia and diabetic retinopathy: A two-sample mendelian randomization study","authors":"Jinyi Xu ,&nbsp;Shengsong Xu ,&nbsp;Xiao Wang ,&nbsp;Chuqi Xiang,&nbsp;Zhenbang Ruan,&nbsp;Mingxin Lu,&nbsp;Liying He,&nbsp;Yin Hu,&nbsp;Xiao Yang","doi":"10.1016/j.aopr.2024.10.003","DOIUrl":"10.1016/j.aopr.2024.10.003","url":null,"abstract":"<div><h3>Objective</h3><div>The association between myopia and diabetic retinopathy (DR) is unclear, with inconsistent results reported, and whether the association represents causality remains unknown. This study aimed to investigate the causal associations of genetically determined myopia with DR, and further explore specific mechanisms.</div></div><div><h3>Methods</h3><div>We conducted two-sample mendelian randomization (MR) analyses of any myopia and high myopia on six DR phenotypes, including any DR, background DR, severe background DR, proliferative DR (PDR), diabetic maculopathy and unspecific DR in the primary study. Mechanism exploration of spherical equivalent refraction (SER), corneal curvature (CC) and axial length (AL) on any DR was carried out subsequently. Single-nucleotide polymorphisms (SNPs), used as genetic instruments, were derived from UK Biobank, Genetic Epidemiology Research on Adult Health and Aging cohort (GERA) and FinnGen. The inverse variance weighted (IVW) method was mainly used to assess the causality, and was complemented with sensitivity analyses and causality direction analyses.</div></div><div><h3>Results</h3><div>Using SNPs that have excluded possible confounders, we discovered suggestive and positive causal associations of any myopia with any DR (IVW: odds ratio [OR] ​= ​1.133, 95% confidence interval [95%CI]: 1.070–1.201, <em>P</em> ​= ​1.91×10⁻⁵) and PDR (IVW: OR ​= ​1.182, 95% CI: 1.088–1.285, <em>P</em> ​= ​8.31×10⁻⁵). Similar but more significant associations were found of high myopia with any DR and PDR (IVW: OR ​= ​1.107, 95%CI: 1.051–1.166, <em>P</em> ​= ​1.39×10⁻⁴; OR ​= ​1.163, 95%CI: 1.088–1.244, <em>P</em> ​= ​8.76×10⁻⁶, respectively). Further mechanism analyses found only AL, rather than SER or CC, was strongly and significantly associated with any DR. These associations were robust in sensitivity analyses and causality direction analyses.</div></div><div><h3>Conclusions</h3><div>We found significant and positive causal associations of any myopia and high myopia with the risk of DR and PDR, which might be related with AL, indicating the significance of myopia control for preventing DR development and progression.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 32-40"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global incidence and trends of ocular cancer: A bibliometric analysis","authors":"Hang Xu ,&nbsp;Alexander C. Rokohl ,&nbsp;Xiaojun Ju ,&nbsp;Yongwei Guo ,&nbsp;Xincen Hou ,&nbsp;Wanlin Fan ,&nbsp;Ludwig M. Heindl","doi":"10.1016/j.aopr.2024.10.004","DOIUrl":"10.1016/j.aopr.2024.10.004","url":null,"abstract":"<div><h3>Background</h3><div>Ocular cancer represents a significant threat to vision and life among various eye diseases. Conjunctival melanoma is regarded as one of the most feared and unpredictable ocular tumors. Considering the global differences in the occurrence of ocular melanoma across different races and regions, this study provides a thorough examination of the current state of research pertaining to the epidemiology of ocular and conjunctival cancers.</div></div><div><h3>Methods</h3><div>This bibliometrics analysis used the Web of Science Core Collection (WoSCC) to collect data from publications on the epidemiology of ocular cancer, including relevant literature from 1951 to 2024. We examined indicators including t publication counts, citation rates, and data on contributing countries, institutions, and journals. Use VOSviewer and CiteSpace for network visualization and Microsoft Excel for data management. Our analysis reveals key trends in the epidemiology of ocular cancer across countries and identifies prominent keywords.</div></div><div><h3>Results</h3><div>A total of 406 articles on ocular cancer were identified, with significant contributions from the United States, the United Kingdom, and Germany. Denmark also plays a crucial role, particularly in conjunctival cancer research. Carol L. Shields is a leading figure widely recognized for her influential citations in ocular cancer epidemiology. The top publication platforms include the <em>British Journal of Ophthalmology</em>, <em>Ophthalmic Epidemiology</em>, and <em>Ophthalmology</em>. Key terms in ocular cancer research focus on prevalence, survival, and epidemiology, while conjunctival cancer studies emphasize malignant melanoma, conjunctiva, and epidemiology. Through keyword co-occurrence and burst analysis, trending topics include prevalence, risk factors, uveal melanoma, choroidal melanoma, malignant melanoma, squamous cell carcinoma, and conjunctiva. For conjunctival cancer, key research areas expected to remain prominent are cell carcinoma, management, recurrence, ocular surface squamous neoplasia, and pathology.</div></div><div><h3>Conclusions</h3><div>This analysis represents the first comprehensive bibliometric review mapping the trends and the knowledge structure in ocular cancer research, specifically from an epidemiological viewpoint. The results meticulously explore and encapsulate the research frontiers for scholars dedicated to the epidemiology of conjunctival cancer.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 22-31"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}