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The mediating role of inflammaging between mitochondrial dysfunction and sarcopenia in aging: a review. 炎症在线粒体功能障碍和肌肉疏松症之间的中介作用:综述。
Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Xin Xu, Zixing Wen

Sarcopenia, characterized by the insidious reduction of skeletal muscle mass and strength, detrimentally affects the quality of life in elderly cohorts. Present therapeutic strategies are confined to physiotherapeutic interventions, signaling a critical need for elucidation of the etiological underpinnings to facilitate the development of innovative pharmacotherapies. Recent scientific inquiries have associated mitochondrial dysfunction and inflammation with the etiology of sarcopenia. Mitochondria are integral to numerous fundamental cellular processes within muscle tissue, including but not limited to apoptosis, autophagy, signaling via reactive oxygen species, and the maintenance of protein equilibrium. Deviations in mitochondrial dynamics, coupled with compromised oxidative capabilities, autophagic processes, and protein equilibrium, result in disturbances to muscular architecture and functionality. Mitochondrial dysfunction is particularly detrimental as it diminishes oxidative phosphorylation, escalates apoptotic activity, and hinders calcium homeostasis within muscle cells. Additionally, deleterious feedback loops of deteriorated respiration, exacerbated oxidative injury, and diminished quality control mechanisms precipitate the acceleration of muscular senescence. Notably, mitochondria exhibiting deficient energetic metabolism are pivotal in precipitating the shift from normative muscle aging to a pathogenic state. This analytical review meticulously examines the complex interplay between mitochondrial dysfunction, persistent inflammation, and the pathogenesis of sarcopenia. It underscores the imperative to alleviate inflammation and amend mitochondrial anomalies within geriatric populations as a strategy to forestall and manage sarcopenia. An initial overview provides a succinct exposition of sarcopenia and its clinical repercussions. The discourse then progresses to an examination of the direct correlation between mitochondrial dysfunction and the genesis of sarcopenia. Concomitantly, it accentuates potential synergistic effects between inflammatory responses and mitochondrial insufficiencies during the aging of skeletal muscle, thereby casting light upon emergent therapeutic objectives. In culmination, this review distills the prevailing comprehension of the mitochondrial and inflammatory pathways implicated in sarcopenia and delineates extant lacunae in knowledge to orient subsequent scientific inquiry.

骨质疏松症的特点是骨骼肌质量和力量的隐性减少,对老年人群的生活质量造成了不利影响。目前的治疗策略仅限于物理治疗干预,这表明迫切需要阐明病因基础,以促进创新药物疗法的开发。最近的科学研究发现,线粒体功能障碍和炎症与肌肉疏松症的病因有关。线粒体是肌肉组织内许多基本细胞过程的组成部分,包括但不限于细胞凋亡、自噬、通过活性氧发出信号以及维持蛋白质平衡。线粒体动力学的偏差,再加上氧化能力、自噬过程和蛋白质平衡受到损害,会导致肌肉结构和功能紊乱。线粒体功能障碍尤其有害,因为它会降低氧化磷酸化,加剧细胞凋亡活动,并阻碍肌肉细胞内的钙平衡。此外,呼吸恶化、氧化损伤加剧和质量控制机制减弱等有害的反馈回路会加速肌肉衰老。值得注意的是,线粒体表现出的能量代谢缺陷是促使肌肉从正常衰老状态转变为致病状态的关键因素。这篇分析性综述细致研究了线粒体功能障碍、持续炎症和肌肉疏松症发病机制之间复杂的相互作用。它强调了在老年群体中缓解炎症和修正线粒体异常作为预防和控制肌肉疏松症策略的必要性。文章首先概述了肌肉疏松症及其临床影响。接着,文章探讨了线粒体功能障碍与肌肉疏松症发生之间的直接关系。同时,它还强调了骨骼肌衰老过程中炎症反应和线粒体功能不足之间潜在的协同效应,从而阐明了新出现的治疗目标。最后,这篇综述提炼了目前对与肌肉疏松症有关的线粒体和炎症途径的理解,并勾勒出现存的知识空白,为后续的科学探索指明了方向。
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引用次数: 0
Bibliometric analysis of the inflammatory mechanisms in knee osteoarthritis in recent 30 years. 近30年来膝关节骨关节炎炎症机制的文献计量分析。
Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Yiyi Chen, Bo Yu, Fei He, Wenjiang Sun, Yuting Song

This study aimed to improve Knee Osteoarthritis (KOA) therapy by evaluating the knowledge framework and investigating research trends in inflammatory mechanisms. Conducting a thorough search on July 31, 2023, using the Science Citation Index Expanded of the Web of Science Core Collection, we identified 1,083 articles authored by 6,159 individuals from 3,610 institutions across 299 countries. China led in productivity with 377 papers, followed by the United States (253) and Japan (60). The University of California System (20 publications), Guangzhou University of Science and Technology (19), Duke University (18), and Shanghai Jiao Tong University (18) were the top institutions. Notably, the USA and Southern Medical University China held significant centrality in countries and institutions, respectively. Among 1,084 co-occurring keywords, "expression", "rheumatoid arthritis", "articular cartilage", "F kappa b", and "Synovial fluid" emerged as highly correlated topics. Analyzing inflammatory mechanisms in KOA through visualization tools offers insights into the knowledge framework, aiding in identifying future trends for better pain control. The study employed CiteSpace, VOS Viewer, and Tableau to analyze research hotspots and frontiers in inflammation mechanisms in KOA. It focused on essential signaling pathways in articular cartilage, synovial membrane, subchondral bone, and synovial fluids of OA patients and animal models, along with potential therapeutic reagents. Future exploration of the interaction between mechanisms can elucidate key factors in different pathways and the efficacy of injection therapy on inflammation.

本研究旨在通过评估知识框架和调查炎症机制的研究趋势来改进膝骨关节炎(KOA)的治疗。2023 年 7 月 31 日,我们使用科学网核心数据库的科学引文索引扩展版进行了全面检索,共发现了 299 个国家 3,610 个机构的 6,159 位学者撰写的 1,083 篇文章。中国以 377 篇论文居首,其次是美国(253 篇)和日本(60 篇)。发表论文最多的机构是加州大学系统(20 篇)、广州科技大学(19 篇)、杜克大学(18 篇)和上海交通大学(18 篇)。值得注意的是,美国和中国南方医科大学分别在国家和机构中占据重要位置。在 1084 个共同出现的关键词中,"表达"、"类风湿性关节炎"、"关节软骨"、"F kappa b "和 "滑膜液 "成为高度相关的主题。通过可视化工具分析 KOA 中的炎症机制,可以深入了解知识框架,有助于确定未来趋势,从而更好地控制疼痛。该研究利用 CiteSpace、VOS Viewer 和 Tableau 分析了 KOA 中炎症机制的研究热点和前沿。研究重点关注 OA 患者和动物模型的关节软骨、滑膜、软骨下骨和滑液中的重要信号通路,以及潜在的治疗试剂。未来对各种机制之间相互作用的探索可以阐明不同途径中的关键因素以及注射疗法对炎症的疗效。
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引用次数: 0
The effects of high and low dose extracorporeal shockwave therapy on immune activation and immunosuppressive markers in elderly patients with osteoarthritis: a study protocol for a randomized controlled trial. 高剂量和低剂量体外冲击波疗法对老年骨关节炎患者免疫激活和免疫抑制标志物的影响:随机对照试验的研究方案。
Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Yilan Sheng, Haiyin Yuan, Lihua Chen, Bo Yu

Objective: This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.

Methods: 120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm2) or low dose (0.10 mJ/mm2) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.

Results: High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.

Conclusion: This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.

目的:本随机对照试验旨在比较高剂量和低剂量体外冲击波疗法(ESWT)对老年骨关节炎患者免疫系统激活和调节的影响:本随机对照试验旨在比较高剂量和低剂量体外冲击波疗法(ESWT)对老年骨关节炎患者免疫系统激活和调节的影响。方法:120 名年龄在 65 岁及以上的膝关节骨关节炎患者将被随机分配接受高剂量(0.25 mJ/mm2)或低剂量(0.10 mJ/mm2)ESWT,每周治疗 4 周。血清细胞因子、受刺激的免疫细胞亚群和T调节细胞将在基线、干预4周后和1个月随访时进行测定:结果:与低剂量 ESWT 相比,高剂量 ESWT 会增加老年骨关节炎患者的促炎细胞因子,减少免疫抑制性 T 调节细胞:本研究将为 ESWT 剂量方案及其不同的免疫调节效果提供证据,从而指导老年肌肉骨骼疾病的最佳治疗方法。
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引用次数: 0
Comparison of the inhibitory and stimulatory effects of Core and NS3 candidate HCV vaccines on the cellular immune response. 比较核心和 NS3 候选 HCV 疫苗对细胞免疫反应的抑制和刺激作用。
Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Kiandokht Borhani, Taravat Bamdad, Ava Hashempour, Amir Salek Farrokhi, Javad Moayedi

Currently, hepatitis C virus (HCV) infects nearly 3% of the global population, the majority of whom are chronically infected; however, hepatitis C vaccines are still in the developmental stage. Numerous studies suggest that the spontaneous resolution of HCV infection and the design of its vaccine are reliant on vital contributions from CTL cell responses and T regulatory cells. Multiple researchers have identified both Core and nonstructural protein 3 (NS3) proteins as crucial immune genes and potential candidates for HCV DNA vaccine design. In this study, Core and NS3 were subcloned and inserted into pcDNA3.1 to construct HCV DNA vaccines administered in mouse models. Furthermore, the effects of Core and NS3 on the induction of CTL and NK were compared in spleen mouse models using the LDH method. Additionally, flow cytometry was employed to investigate the percentage of T regulatory cells (Treg cells) and cells expressing PD-1 in the spleens of the mouse models. Our data indicated that pcDNA3.1+NS3 and pcDNA3.1+Core could enhance CTL and NK activity in mouse models. Importantly, the Treg and PD-1 analysis in mouse models revealed a substantial reduction in the proportions of CD4+/CD25+/Foxp3+ T cells and PD-1+ cells in experimental subjects treated with HCV NS3 along with 5 mg/kg of lenalidomide, utilized as a novel adjuvant, compared to those administered an equivalent dosage of lenalidomide in conjunction with HCV Core. In conclusion, our observations indicated that the NS3-HCV gene had a limited impact on the activation of inhibitory factors. Therefore, NS3 is considered a more suitable candidate for DNA vaccine design compared to Core HCV.

目前,丙型肝炎病毒(HCV)感染了全球近 3% 的人口,其中大多数是慢性感染者;然而,丙型肝炎疫苗仍处于开发阶段。大量研究表明,HCV 感染的自发缓解及其疫苗的设计依赖于 CTL 细胞反应和 T 调节细胞的重要贡献。许多研究人员发现,核心蛋白和非结构蛋白 3 (NS3) 蛋白是关键的免疫基因,也是设计 HCV DNA 疫苗的潜在候选基因。在本研究中,Core 和 NS3 被亚克隆并插入 pcDNA3.1 中,用于构建小鼠模型中的 HCV DNA 疫苗。此外,还使用 LDH 方法比较了 Core 和 NS3 在脾脏小鼠模型中诱导 CTL 和 NK 的效果。此外,我们还采用流式细胞术研究了小鼠模型脾脏中T调节细胞(Treg细胞)和表达PD-1细胞的百分比。我们的数据表明,pcDNA3.1+NS3 和 pcDNA3.1+Core 能增强小鼠模型中 CTL 和 NK 的活性。重要的是,在小鼠模型中进行的Treg和PD-1分析表明,在使用HCV NS3和5毫克/千克来那度胺治疗的实验对象中,CD4+/CD25+/Foxp3+ T细胞和PD-1+细胞的比例大大降低。总之,我们的观察结果表明,NS3-HCV 基因对抑制因子的激活影响有限。因此,与核心 HCV 相比,NS3 被认为是更适合设计 DNA 疫苗的候选基因。
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引用次数: 0
Hemophagocytic lymphohistiocytosis in children with Griscelli syndrome type 2: genetics, laboratory findings and treatment. 格里斯切利综合征2型患儿的嗜血细胞淋巴组织细胞增多症:遗传学、实验室发现和治疗。
Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Ezgi Cay, Ahmet Sezer, Veysel Karakulak, Mahir Serbes, Dilek Ozcan, Atil Bisgin, Utku Aygunes, H Ilgen Sasmaz, Sevinc P Yucel, Tugba Toyran, Derya U Altintas

Griscelli syndrome is a rare inherited autosomal recessive syndrome that causes immunodeficiency. Hemophagocytic lymphohistiocytosis (HLH), which is characterized by a high mortality rate, may develop because of Griscelli syndrome type 2 (GS2). We aimed to share our experience with the diagnosis and treatment methods of patients who developed HLH secondary to GS2. Patients with GS2 who were diagnosed and treated for HLH between 2017 and 2022 at the Cukurova University Division of Pediatric Allergy & Immunology and Division of Pediatric Hematology were included in the study. Microscopic examination of the hair shaft and next-generation sequencing for molecular genetic testing of RAB27A helped in the diagnosis of GS2. The first clinical presentation of 8 patients was HLH. One patient presented with CNS involvement and two patients presented with recurrent fever. Over 5 years, GS2 was diagnosed in 15 patients, of whom 11 (73.3%) developed HLH. The HLH-2004 protocol was used to treat these patients. Hematopoietic stem cell transplantation (HSCT) was performed in five patients who were matched with suitable donors. While all patients who underwent HSCT were alive, three patients who could not undergo HSCT because no donor could be found died. Deletion of CAAGC at nucleotides 514_518 in GS2 patients is associated with CNS involvement and a poor prognosis. HLH may be the first sign of presentation in patients with GS2. Although further research is needed, regardless of the conditioning regimen utilized, early HSCT remains the primary therapy option for preventing GS2-induced mortality in HLH.

格里斯切利综合征是一种罕见的常染色体隐性遗传综合征,会导致免疫缺陷。嗜血细胞性淋巴组织细胞增多症(HLH)的特点是死亡率高,它可能因格里什利综合征 2 型(GS2)而发病。我们的目的是分享我们对因 GS2 而继发 HLH 的患者的诊断和治疗方法的经验。研究纳入了2017年至2022年期间在库库罗瓦大学儿科过敏与免疫学部和儿科血液学部接受诊断和治疗的GS2型HLH患者。毛干显微镜检查和用于 RAB27A 分子遗传检测的新一代测序有助于 GS2 的诊断。8 名患者的首次临床表现为 HLH。一名患者出现中枢神经系统受累,两名患者出现反复发热。5 年间,15 名患者被确诊为 GS2,其中 11 人(73.3%)发展为 HLH。这些患者均采用 HLH-2004 方案进行治疗。为五名匹配到合适供体的患者进行了造血干细胞移植(HSCT)。接受造血干细胞移植的所有患者均存活,但有三名患者因找不到捐献者而无法接受造血干细胞移植,最终死亡。GS2患者核苷酸514_518的CAAGC缺失与中枢神经系统受累和预后不良有关。HLH可能是GS2患者的首发症状。尽管还需要进一步的研究,但无论采用哪种治疗方案,早期造血干细胞移植仍是预防GS2引起的HLH死亡的主要治疗方案。
{"title":"Hemophagocytic lymphohistiocytosis in children with Griscelli syndrome type 2: genetics, laboratory findings and treatment.","authors":"Ezgi Cay, Ahmet Sezer, Veysel Karakulak, Mahir Serbes, Dilek Ozcan, Atil Bisgin, Utku Aygunes, H Ilgen Sasmaz, Sevinc P Yucel, Tugba Toyran, Derya U Altintas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Griscelli syndrome is a rare inherited autosomal recessive syndrome that causes immunodeficiency. Hemophagocytic lymphohistiocytosis (HLH), which is characterized by a high mortality rate, may develop because of Griscelli syndrome type 2 (GS2). We aimed to share our experience with the diagnosis and treatment methods of patients who developed HLH secondary to GS2. Patients with GS2 who were diagnosed and treated for HLH between 2017 and 2022 at the Cukurova University Division of Pediatric Allergy & Immunology and Division of Pediatric Hematology were included in the study. Microscopic examination of the hair shaft and next-generation sequencing for molecular genetic testing of <i>RAB27A</i> helped in the diagnosis of GS2. The first clinical presentation of 8 patients was HLH. One patient presented with CNS involvement and two patients presented with recurrent fever. Over 5 years, GS2 was diagnosed in 15 patients, of whom 11 (73.3%) developed HLH. The HLH-2004 protocol was used to treat these patients. Hematopoietic stem cell transplantation (HSCT) was performed in five patients who were matched with suitable donors. While all patients who underwent HSCT were alive, three patients who could not undergo HSCT because no donor could be found died. Deletion of <i>CAAGC</i> at nucleotides 514_518 in GS2 patients is associated with CNS involvement and a poor prognosis. HLH may be the first sign of presentation in patients with GS2. Although further research is needed, regardless of the conditioning regimen utilized, early HSCT remains the primary therapy option for preventing GS2-induced mortality in HLH.</p>","PeriodicalId":72163,"journal":{"name":"American journal of clinical and experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical approach for specific populations at single-cell resolution: insights for ND-42 mediated mitochondrial derivative function during spermatid elongation. 分析方法的特定群体在单细胞分辨率:见解ND-42介导的线粒体衍生功能在精子延伸。
Pub Date : 2023-10-15 eCollection Date: 2023-01-01
Jiajia Xue, Jinxing Lv
{"title":"Analytical approach for specific populations at single-cell resolution: insights for ND-42 mediated mitochondrial derivative function during spermatid elongation.","authors":"Jiajia Xue, Jinxing Lv","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72163,"journal":{"name":"American journal of clinical and experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of tumoral GSK3-β, PD-L1, and CD8 cell density in urothelial carcinomas, association with tumor grade and overall survival. 尿路上皮癌中肿瘤GSK3-β、PD-L1和CD8细胞密度的表达与肿瘤分级和总生存期的关系
Pub Date : 2023-10-15 eCollection Date: 2023-01-01
Aline Kimberly Almeida Rodrigues, Paulo Goberlanio Silva, Cleto Nogueira, Samuel S Ferreira, Juliana Cordeiro, Benedito Carneiro, Fabio Tavora

Bladder cancer is the most common malignancy in the urinary tract, and is biologically and clinically quite heterogeneous. Around 90% of diagnoses are made in the 6th decade, being more prevalent in males. The programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) axis play a putative role in immune checkpoint and as a means through which cancer evades the immune system. Inhibition of the glicogênio synthase kinase (GSK) 3 leads to the downregulation of PD-1 via upregulation of the transcription factor Tbet. The use of biomarkers PD-L1 and GSK-3β and evaluation of the immune infiltrate have very promising correlations with urothelial carcinoma prognosis and treatment prediction.

Objective: To investigate the protein expression of PD-L1 and GSK-3β and the CD8-positive immune infiltrates in bladder carcinomas.

Materials and methods: This was a cross-sectional study of 140 samples of urothelial carcinomas from 2015 to 2018. Automated digitally assisted scoring and conventional analyses of the markers of GSK-3β (27C10), CD8 (7103β) and PDL-1 (22c3), were reviewed by two pathologists independently and a histologic score was calculated. The density of CD8 was also measured.

Results: The immunoexpression of GSK-3β (91%) was presented in most samples, PD-L1 in 62.9% and CD8 cells present in 46.3% of cases. When analyzed in conjunction, the levels of GSK-3β and PD-L1 (P = 0.033), and CD8 and PD-L1 (P<0.002) showed significant correlations. No significant associations were observed between GSK-3β and CD8. The positivity of GSK-3β and PD-L1 was predominant in high-grade tumors.

Conclusion: Despite the tumor microenvironment heterogeneity, the expression of CD8, GSK-3β and PDL1 could be valuable and GSK-3β could be a potential target in advanced bladder cancer, especially in the context of immunotherapy.

膀胱癌是泌尿道中最常见的恶性肿瘤,在生物学和临床上具有很大的异质性。大约90%的诊断是在60年代做出的,在男性中更为普遍。程序性细胞死亡1 (PD-1)和程序性细胞死亡配体1 (PD-L1)轴被认为在免疫检查点中起作用,并且是癌症逃避免疫系统的一种手段。glicogênio合成酶激酶(GSK) 3的抑制通过上调转录因子Tbet导致PD-1的下调。生物标志物PD-L1和GSK-3β的使用以及免疫浸润的评估与尿路上皮癌的预后和治疗预测有很好的相关性。目的:探讨膀胱癌组织中PD-L1、GSK-3β蛋白表达与cd8阳性免疫浸润的关系。材料和方法:这是一项对2015年至2018年140例尿路上皮癌样本的横断面研究。由两名病理学家独立评估GSK-3β (27C10)、CD8 (7103β)和PDL-1 (22c3)标记物的自动数字辅助评分和常规分析,并计算组织学评分。同时测定CD8的密度。结果:大多数标本中有91%的GSK-3β、62.9%的PD-L1和46.3%的CD8细胞的免疫表达。结论:尽管肿瘤微环境存在异质性,但CD8、GSK-3β和PDL1的表达可能是有价值的,GSK-3β可能是晚期膀胱癌的潜在靶点,特别是在免疫治疗的背景下。
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引用次数: 0
Clinical analysis and methodological evaluation of syphilis infection in patients in a first-class tertiary hospital in Suzhou, China. 苏州市某三甲医院梅毒患者感染的临床分析与方法学评价
Pub Date : 2023-10-15 eCollection Date: 2023-01-01
Sheng Zhang, Chen Ling, Zhongping Qian, Jingping Yin, Qingqin Tang, Ximeng Zhang, Yinjuan Shi, Bin Feng, Jie Ding, Qian Yang

Objective: To explore the distribution and epidemiological characteristics of patients with syphilis in a first-class tertiary hospital and to evaluate the coincidence rate between chemiluminescence immunoassay (CLIA) and Treponema pallidum particle agglutination assay (TPPA).

Methods: The medical records of 247,501 outpatients and inpatients were retrospectively analyzed. TPPA was used to verify positive and suspected cases, and the coincidence rate between CLIA and TPPA was evaluated. Receiver operating characteristic (ROC) curve was used to determine optimal diagnostic thresholds.

Results: Of the 247,501 serum samples, 5,173 were detected positive for syphilis using CLIA, with a detection rate of 2.09% and a men-to-women ratio of 1.39. The chi-square test showed that sex and age were both factors that affected the detection rate (χ2=229.51, P < 0.0001). In addition, urology, orthopedics, cardiology, general surgery, gastroenterology, and gynecology represented the top six departments with the highest numbers of positive cases. Comparative analysis showed that the overall coincidence rate between CLIA and TPPA was 80.24%. Analysis of the ROC curve showed that the area under the curve (AUC) was 0.936 (95% confidence interval [CI]: 0.929-0.942, P < 0.0001) using sample/cut-off value (S/CO) as a diagnostic indicator. The results showed that an S/CO value of 3.945 was the best diagnostic value for the CLIA method, with a diagnostic specificity of 93.64% and a sensitivity of 81.90%.

Conclusions: Syphilis is widely distributed in various hospital departments and primarily affects middle-aged and older individuals. For cases that have been initially screened as positive or suspicious, TPPA and other tests should be used for verification to avoid misdiagnosis and missed diagnosis.

目的:了解某三甲医院梅毒患者的分布及流行病学特征,评价化学发光免疫分析法(CLIA)与梅毒螺旋体颗粒凝集试验(TPPA)的符合率。方法:对247501例门诊和住院患者的病历资料进行回顾性分析。采用TPPA对阳性和疑似病例进行验证,并评估CLIA与TPPA的符合率。采用受试者工作特征(ROC)曲线确定最佳诊断阈值。结果:247501份血清标本中,CLIA检测梅毒阳性5173份,检出率为2.09%,男女比为1.39。卡方检验显示,性别和年龄均是影响检出率的因素(χ2=229.51, P < 0.0001)。此外,泌尿外科、骨科、心脏科、普外科、消化内科和妇科是阳性病例最多的前6个科室。对比分析显示,CLIA与TPPA的总体符合率为80.24%。ROC曲线分析显示,以样本/截断值(S/CO)作为诊断指标,曲线下面积(AUC)为0.936(95%置信区间[CI]: 0.929-0.942, P < 0.0001)。结果表明,S/CO值为3.945是CLIA方法的最佳诊断值,诊断特异性为93.64%,敏感性为81.90%。结论:梅毒在医院各科室分布广泛,以中老年人群为主。对于初步筛查为阳性或可疑病例,应采用TPPA等检测进行验证,避免误诊和漏诊。
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引用次数: 0
Association between IL-10 (at position -592) and IL-4 (at position -589) genotype polymorphism with atopic and non-atopic asthma in children. IL-10(-592位)和IL-4(-589位)基因型多态性与儿童特应性和非特应性哮喘的关系
Pub Date : 2023-10-15 eCollection Date: 2023-01-01
Anahita Razaghian, Nima Parvaneh, Ali Akbar Amirzargar, Matineh Nirouei, Mohammad Gharagozlou

Objectives: Asthma is the most prevalent respiratory disease, caused by chronic bronchial inflammation. Cytokines are known to play an important role in the pathophysiology of asthma. This study aimed to compare interleukin-4 (IL-4) and interleukin-10 (IL-10) gene polymorphisms between Iranian pediatric asthmatic patients and healthy controls and to investigate IL4 and IL10 gene variations in children with atopic and non-atopic asthma phenotypes.

Methods: In this prospective case-control study, a total of 95 unrelated pediatric asthmatic patients were recruited according to the Global Initiative for Asthma (GINA) criteria. The control group comprised two subgroups of 538 and 491 healthy individuals, undergoing IL4 and IL10 polymorphism assessments, respectively. The IL4 -589C/T (rs2243250) and IL10 -592A/C (rs1800872) gene polymorphisms were evaluated using the tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) assay.

Results: The findings indicated a significant difference in IL4 gene polymorphisms at position -589 between the asthmatic and healthy control groups. However, no significant difference was found in terms of IL10 gene polymorphisms, and they were not associated with atopy in the patients.

Conclusion: The IL4 -589C/T polymorphism (rs2243250) can be a risk factor for asthma susceptibility, whereas the IL10 -592A/C polymorphism (rs1800872) is not a risk factor in the Iranian pediatric population. The results also showed that these polymorphisms are not risk factors for atopy in asthmatic children.

目的:哮喘是最常见的呼吸系统疾病,由慢性支气管炎症引起。众所周知,细胞因子在哮喘的病理生理中起着重要作用。本研究旨在比较伊朗儿童哮喘患者和健康对照之间的白细胞介素-4 (IL-4)和白细胞介素-10 (IL-10)基因多态性,并探讨IL-4和IL-10基因在特应性和非特应性哮喘表型儿童中的变异。方法:在这项前瞻性病例对照研究中,根据全球哮喘倡议(GINA)的标准,共招募了95名无关联的儿童哮喘患者。对照组由538名和491名健康个体组成,分别进行IL4和IL10多态性评估。采用四引物扩增法测定il -589C/T (rs2243250)和il -592A/C (rs1800872)基因多态性。结果:哮喘组与健康对照组il -589位点基因多态性存在显著差异。然而,在IL10基因多态性方面没有发现显著差异,并且它们与患者的特应性无关。结论:IL4 -589C/T多态性(rs2243250)可能是伊朗儿童哮喘易感性的危险因素,而IL10 -592A/C多态性(rs1800872)不是危险因素。结果还表明,这些多态性不是哮喘儿童特应性的危险因素。
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引用次数: 0
Parental telomeres implications on immune senescence of newborns. 父母端粒对新生儿免疫衰老的影响。
Pub Date : 2023-10-15 eCollection Date: 2023-01-01
Sadia Farrukh, Saeeda Baig

Telomere, the biological chronometer, and its effect on the immune system considerably varies among individuals. During pregnancy, multiple risk factors affect telomere reprogramming during fetal life which can lead to health disparities in newborns. These changes may cause a long-term impact on the telomere genetics of the newborn and become a reason for lifelong health implications and immune senescence. Therefore, telomere shortening in parents due to genetic variation may act as a hallmark of immune senescence and aging in their newborns.

端粒是生物计时器,它对免疫系统的影响因人而异。在怀孕期间,多种危险因素会影响胎儿生命期间的端粒重编程,从而导致新生儿的健康差异。这些变化可能对新生儿的端粒遗传学造成长期影响,并成为终身健康问题和免疫衰老的原因。因此,由于遗传变异,父母端粒缩短可能是新生儿免疫衰老和衰老的标志。
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American journal of clinical and experimental immunology
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