Pub Date : 2022-12-15DOI: 10.53043/2347-3894.acam90049
Chaoqiong Yuan, Xin Fu, Wenting Yu
Type II diabetes mellitus (T2DM) is a group of metabolic diseases characterized by hyperglycemia, and it will cause a variety of complications. Through the research on Danggui-Shaoyao-San (DSS), scholars found that it has an active role in the treatment of diabetes and some complications. Danggui-Shaoyao-San polysaccharide (P-DSS) is the main component of Danggui-Shaoyao-San. P-DSS can participate in the physiological regulation of oxidative stress, anti-inflammatory, glucose and lipid metabolism, endoplasmic reticulum stress, bile acid metabolism and iron metabolism, especially bile acid can effectively regulate the disorder of glucose and lipid metabolism in the body, which provides a new idea for the treatment of diabetes. In addition, the therapeutic effect of P-DSS on diabetic complications may also be related to cell autophagy and intestinal flora, but there is little systematic analysis on the mechanism of P-DSS in treating diabetes and its complications. Therefore, this article reviews the potential mechanism of P-DSS in treating diabetes and its complications in detail, providing a reasonable theoretical basis for further research on P-DSS in treating T2DM.
{"title":"Research Progress on the Mechanism of Action of Danggui-Shaoyao-San Polysaccharide on Some Complications of Type II Diabetes Mellitus: A Review","authors":"Chaoqiong Yuan, Xin Fu, Wenting Yu","doi":"10.53043/2347-3894.acam90049","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90049","url":null,"abstract":"Type II diabetes mellitus (T2DM) is a group of metabolic diseases characterized by hyperglycemia, and it will cause a variety of complications. Through the research on Danggui-Shaoyao-San (DSS), scholars found that it has an active role in the treatment of diabetes and some complications. Danggui-Shaoyao-San polysaccharide (P-DSS) is the main component of Danggui-Shaoyao-San. P-DSS can participate in the physiological regulation of oxidative stress, anti-inflammatory, glucose and lipid metabolism, endoplasmic reticulum stress, bile acid metabolism and iron metabolism, especially bile acid can effectively regulate the disorder of glucose and lipid metabolism in the body, which provides a new idea for the treatment of diabetes. In addition, the therapeutic effect of P-DSS on diabetic complications may also be related to cell autophagy and intestinal flora, but there is little systematic analysis on the mechanism of P-DSS in treating diabetes and its complications. Therefore, this article reviews the potential mechanism of P-DSS in treating diabetes and its complications in detail, providing a reasonable theoretical basis for further research on P-DSS in treating T2DM.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44754116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.53043/2347-3894.acam90047
J. N. Hansen
Science in the modern age advances by the scientific method, which involves the experimental testing of hypotheses, continually revising them to better fit experimental observations. Nearly all articles in scientific journals report results of experiments that test hypotheses, that were in turn tested by earlier experiments. That means that the experiments that come next are based on those that have gone before. A flaw is that it does not provide a route to provide hypotheses that are completely new, and not inspired by previous hypotheses and experimental results. Centuries and millennia ago the primary means of discovery was Philosophy, which was based on the premise that the path to knowledge is to start from fundamental axioms and through a logical process of pure reason, arrive at explanations of everything. I thought it possible that by invoking a philosophical approach one might discover sui generis concepts that would be a source of novel hypotheses that were not inspired by previous hypotheses. Inspired by Rene’ Descartes’ ‘I think therefore I am,’ I chose instead ‘That which cannot be observed does not exist.’ Following a logical path from there was easy, and I was surprised how many novel concepts emerged. Unlike most philosophical ideas, some of these concepts were subject to experimental tests. One was that a thought exerts a physical force, and a collection of our thoughts could provide a measurable force. This led to the design of a pendulum that was able to detect and analyze the substantial forces that surround a subject. These experiments would not have been done without the idea that thoughts exert a physical force. Another novel concept is that translocation of objects is a complex process that resembles a chemical reaction. This was used to derive an equation that embodies the laws of motion and defines terms for inertia and momentum. The concept was expanded by an argument that it could be possible for objects to accelerate and slow down without having to overcome inertia and momentum. Other concepts were related to memory and consciousness and suggested completely new ways by which the brain forms and recalls memories. There are many studies of the brain, and these are designed to test current hypotheses. Instead of performing new experiments, one could take those experimental results and see which hypothesis better explains them. Examples are provided that the show the philosophical hypothesis is the better one. Many concepts were discovered that are not described here. It is likely that many are incorrect, but perhaps some are not. Those that are correct could provide previously unavailable hypotheses that could drive discovery new directions. If this approach bears fruit, it may be useful to merge classical philosophical approaches with modern scientific methods. It may be a way to recover some of what was lost when the Library of Alexandria was burned.
{"title":"A Philosophical Approach to Aspects of Memory and Consciousness","authors":"J. N. Hansen","doi":"10.53043/2347-3894.acam90047","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90047","url":null,"abstract":"Science in the modern age advances by the scientific method, which involves the experimental testing of hypotheses, continually revising them to better fit experimental observations. Nearly all articles in scientific journals report results of experiments that test hypotheses, that were in turn tested by earlier experiments. That means that the experiments that come next are based on those that have gone before. A flaw is that it does not provide a route to provide hypotheses that are completely new, and not inspired by previous hypotheses and experimental results. Centuries and millennia ago the primary means of discovery was Philosophy, which was based on the premise that the path to knowledge is to start from fundamental axioms and through a logical process of pure reason, arrive at explanations of everything. I thought it possible that by invoking a philosophical approach one might discover sui generis concepts that would be a source of novel hypotheses that were not inspired by previous hypotheses. Inspired by Rene’ Descartes’ ‘I think therefore I am,’ I chose instead ‘That which cannot be observed does not exist.’ Following a logical path from there was easy, and I was surprised how many novel concepts emerged. Unlike most philosophical ideas, some of these concepts were subject to experimental tests. One was that a thought exerts a physical force, and a collection of our thoughts could provide a measurable force. This led to the design of a pendulum that was able to detect and analyze the substantial forces that surround a subject. These experiments would not have been done without the idea that thoughts exert a physical force. Another novel concept is that translocation of objects is a complex process that resembles a chemical reaction. This was used to derive an equation that embodies the laws of motion and defines terms for inertia and momentum. The concept was expanded by an argument that it could be possible for objects to accelerate and slow down without having to overcome inertia and momentum. Other concepts were related to memory and consciousness and suggested completely new ways by which the brain forms and recalls memories. There are many studies of the brain, and these are designed to test current hypotheses. Instead of performing new experiments, one could take those experimental results and see which hypothesis better explains them. Examples are provided that the show the philosophical hypothesis is the better one. Many concepts were discovered that are not described here. It is likely that many are incorrect, but perhaps some are not. Those that are correct could provide previously unavailable hypotheses that could drive discovery new directions. If this approach bears fruit, it may be useful to merge classical philosophical approaches with modern scientific methods. It may be a way to recover some of what was lost when the Library of Alexandria was burned.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48640137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.53043/2347-3894.acam90048
A. Toraño, I. Moreno, J. A. Infantes, M. Domínguez
Three biochemical parameters—the on-rate (k+1), the dissociation rate (k-1), and the equilibrium (Ka) constants—describe the antibody interaction with a ligand. In addition, the antibody immune reactive fraction (IRF) is important because it affects k+1 and Ka constant values. The on-rate and dissociation constants are kinetic, but the equilibrium constant is a thermodynamic parameter, and the methods for their determination are different. Among the available methods to determine these parameters, only surface plasmon resonance (SPR)-based techniques allow calculation of the three antibody constants in a single experiment. However, conventional immunoassays are also suitable to determine antibody constants. Here, we describe some enzyme immunoassays (ELISA) methods developed in our laboratory to, i) quantitate mAb in culture supernatants from the initial velocity of the progress curve, ii) determine mAb IRF by a two-step ELISA method, iii) calculate mAb on-rate constant by kinetic ELISA based on time-course data of ligand binding to capture mAb, and, iv) describe a competitive-inhibition ELISA to measure the inhibition constant (Ki) of mAb binding to plate-bound ligand, in the presence of competing concentrations of mAb and soluble ligand.
{"title":"An Overview of ELISA-Based Initial Velocity Methods to Measure the Immunoreactive Fraction, Association Rate, And Equilibrium Constants of Monoclonal Antibodies","authors":"A. Toraño, I. Moreno, J. A. Infantes, M. Domínguez","doi":"10.53043/2347-3894.acam90048","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90048","url":null,"abstract":"Three biochemical parameters—the on-rate (k+1), the dissociation rate (k-1), and the equilibrium (Ka) constants—describe the antibody interaction with a ligand. In addition, the antibody immune reactive fraction (IRF) is important because it affects k+1 and Ka constant values. The on-rate and dissociation constants are kinetic, but the equilibrium constant is a thermodynamic parameter, and the methods for their determination are different. Among the available methods to determine these parameters, only surface plasmon resonance (SPR)-based techniques allow calculation of the three antibody constants in a single experiment. However, conventional immunoassays are also suitable to determine antibody constants. Here, we describe some enzyme immunoassays (ELISA) methods developed in our laboratory to, i) quantitate mAb in culture supernatants from the initial velocity of the progress curve, ii) determine mAb IRF by a two-step ELISA method, iii) calculate mAb on-rate constant by kinetic ELISA based on time-course data of ligand binding to capture mAb, and, iv) describe a competitive-inhibition ELISA to measure the inhibition constant (Ki) of mAb binding to plate-bound ligand, in the presence of competing concentrations of mAb and soluble ligand.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45065995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.53043/2347-3894.acam90046
J. N. Hansen
Earlier experiments have established that a torsion pendulum consisting of a steel mesh hemisphere suspended by a nylon filament above a human subject is capable of detecting and collecting data that may represent human bioenergy. Among the effects observed are a wide range of subject-induced rotational frequencies of the pendulum and displacement of the pendulum from its natural center of oscillation. The nylon filament support confers the properties of a simple harmonic oscillator (sho) to the pendulum. The resulting sho swings of the pendulum obscure smaller swings that correspond to subject effects on the pendulum. For this work, it was desired to modify the pendulum to reduce or eliminate the sho oscillatory swings. A proposed modification was to replace the nylon filament with a length of chain. The idea was that the chain would confer properties of an ‘energy well’ to the pendulum. Rotational forces exerted on the chain-supported pendulum would cause the chain to twist and thus rise up the side of the energy well. Ideally, the only restoring force would be the tendency of the twisted links to untwist, so as to drop back down to the bottom of the energy well. This strategy was successful. Control experiments in which the chain-supported pendulum was stimulated to rotational motion by air puffs showed a rapid deflection of the pendulum, which represented traveling up the side of the energy well. The deflected pendulum then immediately returned to its original position and remained there, with no sho oscillations being evident. This is consistent with the chain-link pendulum conforming to the characteristics of an energy well. The chain-supported pendulum was used to assess subject effects on the pendulum. The basic pattern of the subject effects resembled those obtained with a nylon filament-supported pendulum, except the large sho swings that are a feature of the filament-supported pendulum, were absent from the effects observed by the chain-supported pendulum. Thus, for the first time, the pattern of subject-induced effects could be observed, measured, and analyzed without being obscured by sho oscillations. Soon after the subject was seated under the pendulum, its rotational motion drove the pendulum rotational position up one side of the energy well, where it stayed throughout the experiment. This establishes that the force is a spiral force, which conforms to our earlier observations. The now-visible underlying subject-induced oscillations are nuanced and sophisticated and are reminiscent of the complexity of music or speech. Moreover, these oscillations encompass a range of very low frequencies, from less than 0.01 Hz to 0.15 Hz. The frequency amplitudes rise dramatically at the lowest frequencies, suggesting the existence of additional even lower frequencies; but if they exist, the current pendulum cannot detect them. The frequency amplitudes toward the upper end do not fade away completely, suggesting that what is observed represents
{"title":"Studies of Putative Human Bioenergy Using a Torsion Pendulum with a Metal Chain-Link Support instead of a Nylon Filament Support","authors":"J. N. Hansen","doi":"10.53043/2347-3894.acam90046","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90046","url":null,"abstract":"Earlier experiments have established that a torsion pendulum consisting of a steel mesh hemisphere suspended by a nylon filament above a human subject is capable of detecting and collecting data that may represent human bioenergy. Among the effects observed are a wide range of subject-induced rotational frequencies of the pendulum and displacement of the pendulum from its natural center of oscillation. The nylon filament support confers the properties of a simple harmonic oscillator (sho) to the pendulum. The resulting sho swings of the pendulum obscure smaller swings that correspond to subject effects on the pendulum. For this work, it was desired to modify the pendulum to reduce or eliminate the sho oscillatory swings. A proposed modification was to replace the nylon filament with a length of chain. The idea was that the chain would confer properties of an ‘energy well’ to the pendulum. Rotational forces exerted on the chain-supported pendulum would cause the chain to twist and thus rise up the side of the energy well. Ideally, the only restoring force would be the tendency of the twisted links to untwist, so as to drop back down to the bottom of the energy well. This strategy was successful. Control experiments in which the chain-supported pendulum was stimulated to rotational motion by air puffs showed a rapid deflection of the pendulum, which represented traveling up the side of the energy well. The deflected pendulum then immediately returned to its original position and remained there, with no sho oscillations being evident. This is consistent with the chain-link pendulum conforming to the characteristics of an energy well. The chain-supported pendulum was used to assess subject effects on the pendulum. The basic pattern of the subject effects resembled those obtained with a nylon filament-supported pendulum, except the large sho swings that are a feature of the filament-supported pendulum, were absent from the effects observed by the chain-supported pendulum. Thus, for the first time, the pattern of subject-induced effects could be observed, measured, and analyzed without being obscured by sho oscillations. Soon after the subject was seated under the pendulum, its rotational motion drove the pendulum rotational position up one side of the energy well, where it stayed throughout the experiment. This establishes that the force is a spiral force, which conforms to our earlier observations. The now-visible underlying subject-induced oscillations are nuanced and sophisticated and are reminiscent of the complexity of music or speech. Moreover, these oscillations encompass a range of very low frequencies, from less than 0.01 Hz to 0.15 Hz. The frequency amplitudes rise dramatically at the lowest frequencies, suggesting the existence of additional even lower frequencies; but if they exist, the current pendulum cannot detect them. The frequency amplitudes toward the upper end do not fade away completely, suggesting that what is observed represents","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44097829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Many Covid-19 patients suffer from various aberrant inflammatory pathologies due to cytokine storm. Besides pharmacologic therapy, acupuncture therapy has been reported to be effective in treating inflammation. This case report shared one case of post Covid-19 patient with finger stiffness and liver contraction treated by acupuncture. Methods: This is a case report of using acupuncture to treat post Covid-19 patient with finger stiffness and evidence of liver contraction based on ultrasound imaging. Evaluation is based on patient reported outcome measures (PROM) and ultrasound imaging of the liver. Results: The patient is a female, 52 years old, suffering from post-Covid-19 finger stiffness and liver contraction as shown by ultrasound imaging. Clinical diagnosis based on traditional Chinese medicine (TCM) was liver blood deficiency pattern (ICD-11: SF54). Acupuncture therapy was done accordingly to soothe the liver Qi and replenish the liver blood deficiency. Soon afterwards, the stiffness was greatly relieved with simultaneous improvement in her liver volume. Conclusion: Acupuncture therapy is effective for treating post Covid-19 patient with finger stiffness and liver contraction as shown in the aforementioned case.
{"title":"Post Covid-19 Finger Stiffness with Liver Contraction and Immediate Recovery with Acupuncture: Case Report","authors":"Pita Wulansari, Willie Japaries, Mayang Wulandari, Wijono Sukaputra Agussalim","doi":"10.53043/2347-3894.acam90044","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90044","url":null,"abstract":"Introduction: Many Covid-19 patients suffer from various aberrant inflammatory pathologies due to cytokine storm. Besides pharmacologic therapy, acupuncture therapy has been reported to be effective in treating inflammation. This case report shared one case of post Covid-19 patient with finger stiffness and liver contraction treated by acupuncture. Methods: This is a case report of using acupuncture to treat post Covid-19 patient with finger stiffness and evidence of liver contraction based on ultrasound imaging. Evaluation is based on patient reported outcome measures (PROM) and ultrasound imaging of the liver. Results: The patient is a female, 52 years old, suffering from post-Covid-19 finger stiffness and liver contraction as shown by ultrasound imaging. Clinical diagnosis based on traditional Chinese medicine (TCM) was liver blood deficiency pattern (ICD-11: SF54). Acupuncture therapy was done accordingly to soothe the liver Qi and replenish the liver blood deficiency. Soon afterwards, the stiffness was greatly relieved with simultaneous improvement in her liver volume. Conclusion: Acupuncture therapy is effective for treating post Covid-19 patient with finger stiffness and liver contraction as shown in the aforementioned case.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42670893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-09DOI: 10.53043/2347-3894.acam90043
Ho-Sung Lee, In-Hee Lee, Sang-In Park, Dae-Yeon Lee
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (HER2PBC), a subset of breast cancer (BC), results from overexpression and hyperactivation of the oncogene HER2. This subtype is observed in 20-30% of all patients with BC. FDY003 is an herbal prescription comprising Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris, and its suppressive effects on HER2PBC cells have been previously investigated. However, its anticancer mechanisms, and specifically its actions on HER2PBC cells, have not been fully elucidated. Thus, we applied network pharmacology (NP) methodology to FDY003, a widely used technique that effectively and comprehensively investigates the pharmacological features of herbal drugs, to explore its mechanisms against HER2PBC. FDY003 exhibited inhibitory activity on HER2PBC cell viability, and it improved the efficacy of the HER2-targeting therapeutic. NP analysis identified 8 bioactive ingredients and 69 HER2PBC-associated genes that were targeted by those ingredients. Gene ontology analysis of the HER2PBC-associated genes targeted by FDY003 indicated that FDY003 might exhibit pharmacological effects by regulating the behaviors of HER2PBC cells, such as proliferation/growth arrest and survival/death. Moreover, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that FDY003 might affect critical pathways responsible for HER2PBC pathology, including the ErbB, HIF-1, JAK-STAT, MAPK, p53, PD-L1/PD-1, PI3K-Akt, Ras, TNF, and VEGF cascades. The NP analysis results suggested multitarget-multipathway regulatory characteristics of FDY003 against HER2PBC, focusing on its network mechanisms.
{"title":"Mechanistic Study of the Herbal Drug FDY003 for the Treatment of HER2-Positive Breast Cancer via Network Pharmacology Analysis","authors":"Ho-Sung Lee, In-Hee Lee, Sang-In Park, Dae-Yeon Lee","doi":"10.53043/2347-3894.acam90043","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90043","url":null,"abstract":"Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (HER2PBC), a subset of breast cancer (BC), results from overexpression and hyperactivation of the oncogene HER2. This subtype is observed in 20-30% of all patients with BC. FDY003 is an herbal prescription comprising Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris, and its suppressive effects on HER2PBC cells have been previously investigated. However, its anticancer mechanisms, and specifically its actions on HER2PBC cells, have not been fully elucidated. Thus, we applied network pharmacology (NP) methodology to FDY003, a widely used technique that effectively and comprehensively investigates the pharmacological features of herbal drugs, to explore its mechanisms against HER2PBC. FDY003 exhibited inhibitory activity on HER2PBC cell viability, and it improved the efficacy of the HER2-targeting therapeutic. NP analysis identified 8 bioactive ingredients and 69 HER2PBC-associated genes that were targeted by those ingredients. Gene ontology analysis of the HER2PBC-associated genes targeted by FDY003 indicated that FDY003 might exhibit pharmacological effects by regulating the behaviors of HER2PBC cells, such as proliferation/growth arrest and survival/death. Moreover, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that FDY003 might affect critical pathways responsible for HER2PBC pathology, including the ErbB, HIF-1, JAK-STAT, MAPK, p53, PD-L1/PD-1, PI3K-Akt, Ras, TNF, and VEGF cascades. The NP analysis results suggested multitarget-multipathway regulatory characteristics of FDY003 against HER2PBC, focusing on its network mechanisms.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46242751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-09DOI: 10.53043/2347-3894.acam90045
J. Audette
{"title":"Acupuncture-Immune Modulation and the Gut-Lung Axis","authors":"J. Audette","doi":"10.53043/2347-3894.acam90045","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90045","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46862690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-09DOI: 10.53043/2347-3894.acam90041
Du Fusheng, Du Yanping, Ping Jiejie
Objective: To report a case of “recurrent giant malignant melanoma of the right eyelid” in May 2019. Methods: The patient was found to have a recurrence of a huge mass in the right eyelid, which was surgically removed after admission, and histopathological section was given to confirm the diagnosis. Results: CT and histopathological sections were used to finally diagnose the recurrence of giant malignant melanoma of the right eyelid, which prevented the further deterioration of the disease. Conclusion: For this disease, it is easy to diagnose and treat early, and the disease is highly malignant, and it is easy to metastasize to the brain, liver and bone through blood and/or lymph nodes, and it is easy to recur. Therefore, the primary tumor should be enlarged during the operation. After resection, radiotherapy and chemotherapy can be combined according to the situation after operation, and it is particularly important to do postoperative observation and follow-up.
{"title":"A Case of Recurrent Giant Malignant Melanoma of Eyelid with Orbital Infiltration","authors":"Du Fusheng, Du Yanping, Ping Jiejie","doi":"10.53043/2347-3894.acam90041","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90041","url":null,"abstract":"Objective: To report a case of “recurrent giant malignant melanoma of the right eyelid” in May 2019. Methods: The patient was found to have a recurrence of a huge mass in the right eyelid, which was surgically removed after admission, and histopathological section was given to confirm the diagnosis. Results: CT and histopathological sections were used to finally diagnose the recurrence of giant malignant melanoma of the right eyelid, which prevented the further deterioration of the disease. Conclusion: For this disease, it is easy to diagnose and treat early, and the disease is highly malignant, and it is easy to metastasize to the brain, liver and bone through blood and/or lymph nodes, and it is easy to recur. Therefore, the primary tumor should be enlarged during the operation. After resection, radiotherapy and chemotherapy can be combined according to the situation after operation, and it is particularly important to do postoperative observation and follow-up.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45894116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-09DOI: 10.53043/2347-3894.acam90042
James E. Williams
Background: Long-COVID is the “long tail” of the COVID-19 Pandemic. Even though surges in cases have occurred since early 2020, overall, the Pandemic is in decline. However, a chronic form emerged that affects millions and without any sign of letting up. Diagnosis of Long-COVID is illusive. No specific drug safely and effectively addresses this condition. Restoring health and the search for relief became essentially the responsibility of patients and self-help groups. Acupuncture has proven safe and effective in symptom management and may flatten the disease progression curve. Objective: To systematically review reports and case studies since 2020 to evaluate the safety and efficacy of acupuncture for the management of Long-COVID. Results: The author reports on three review papers and two case studies. All results support the thesis that acupuncture is an effective and safe treatment for Long-COVID. Acupuncture provides symptom relief and may shorten the duration of illness. Conclusions: Acupuncture is a safe and effective treatment for managing Long-COVID.
{"title":"Acupuncture Treatment of Long-COVID: A Narrative Review of Selected Case Studies and Review Articles","authors":"James E. Williams","doi":"10.53043/2347-3894.acam90042","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90042","url":null,"abstract":"Background: Long-COVID is the “long tail” of the COVID-19 Pandemic. Even though surges in cases have occurred since early 2020, overall, the Pandemic is in decline. However, a chronic form emerged that affects millions and without any sign of letting up. Diagnosis of Long-COVID is illusive. No specific drug safely and effectively addresses this condition. Restoring health and the search for relief became essentially the responsibility of patients and self-help groups. Acupuncture has proven safe and effective in symptom management and may flatten the disease progression curve. Objective: To systematically review reports and case studies since 2020 to evaluate the safety and efficacy of acupuncture for the management of Long-COVID. Results: The author reports on three review papers and two case studies. All results support the thesis that acupuncture is an effective and safe treatment for Long-COVID. Acupuncture provides symptom relief and may shorten the duration of illness. Conclusions: Acupuncture is a safe and effective treatment for managing Long-COVID.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49347684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-09DOI: 10.53043/2347-3894.acam90040
T. Jin, Hua-fang Zhang, Jingyun Zhang, Haiying Wang, Zhaohui Xu
Fructus Arctii, the dried ripe fruit of Arctium lappa L. has been used to treat diabetes since ancient times in China. Total lignans from Fructus Arctii (TLFA) and chlorogenic acid (3-O caffeoylquinic acid, CA) are the main components of it, which have been reported to have hypoglycemic activity respectively. In this study, they were combined according to several content ratios that different from the ratio they exist in Fructus Arctii, for obtaining stronger hypoglycemic effect. KKAy mice, a spontaneous Type 2 diabetic model were gavaged once daily with the experimentaldrugs for 6 weeks. The result indicates that when CA and TLFA were used alone, their hypoglycemic effect were lower than that of metformin. However, when they are used in combination, their hypoglycemic effect has been greatly strengthened, and the effect of the formula is not a simple addition of the activities of the two substances.
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