Pub Date : 2022-06-07DOI: 10.53043/2347-3894.acam90036
Abhishare Reddy N, Ahmed N in, Ahteskam M in, Antony B in, Alejnikov I Ru
The authors (from their own experience and based on scientific literature) state that the old method of osseointegration, which had served the profession of dental implantology is outdated and full of flaws. It does not meet the expectations of the patients and causes severe problems the longer dental implant remain in the oral cavity. The Technology of the Strategic Implant® has overcome the major problems which are associated to conventional oral implantology and of the method of “osseointegration”. Conventional oral implantology and the method of osseointegration is not the specialist standard any more today.
{"title":"Goodbye “Osseointegration”: Statement of the International Implant Foundation (Munich, Germany) and Strategic Implant® specialists from around the World","authors":"Abhishare Reddy N, Ahmed N in, Ahteskam M in, Antony B in, Alejnikov I Ru","doi":"10.53043/2347-3894.acam90036","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90036","url":null,"abstract":"The authors (from their own experience and based on scientific literature) state that the old method of osseointegration, which had served the profession of dental implantology is outdated and full of flaws. It does not meet the expectations of the patients and causes severe problems the longer dental implant remain in the oral cavity. The Technology of the Strategic Implant® has overcome the major problems which are associated to conventional oral implantology and of the method of “osseointegration”. Conventional oral implantology and the method of osseointegration is not the specialist standard any more today.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48137531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.53043/2347-3894.acam90039
Jie Dou
{"title":"TDP-43: A Key of Neurodegenerative Disease","authors":"Jie Dou","doi":"10.53043/2347-3894.acam90039","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90039","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42862306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.53043/2347-3894.acam90037
J. N. Hansen
These results extend what is known about the effects of a human subject sitting under a torsion pendulum. Previous results showed that subjects affected the pendulum in significant ways. Substantial shifts of the center of oscillation of the pendulum, shifts as large as 2.2 cm (7 deg) requiring a force that is equivalent to 45 mg were observed. Many new frequencies of oscillation of the pendulum were introduced when a subject was present. Dramatic changes in the amplitudes of oscillation of the pendulum were observed throughout the experiments; increasing, decreasing, and increasing again, in quasi-consistent patterns. These shifts of the center of oscillation, the new frequencies of oscillation, and the changes in amplitudes all persisted for 30-60 min after the subject has left the pendulum. These effects have been variously attributed to ‘human bioenergy,’ or to simple cranial heat convection currents. The physical nature of the forces causing these effects remains uncertain. Until now all the experiments we have performed have used ‘control subjects,’ which refers to subjects with no known abilities that would affect the pendulum in unusual ways. In this work, a subject who had 45 years of daily experience with a particular type of meditation ‘sound current meditation’ was recruited. The purpose was to see if different mental states such as a meditative state versus a non-meditative sate, would affect the pendulum differently. These results establish that they are different, both qualitatively and quantitatively, and that the effects by the experienced meditator were significantly different than those routinely seen with ‘control subjects.’ A new kind of experiment was performed by having subjects sit beside the pendulum instead of directly under it. Subjects were the ‘experienced meditator,’ and a ‘control subject.’ Effects on the pendulum with subjects sitting beside the pendulum were diminished in amplitude but were otherwise similar to subjects sitting directly under the pendulum. Although the possibility of cranial heat convection currents being able to exert these effects from a significant distance is not eliminated, the argument that cranial heat convection currents are solely responsible for subject effects on the pendulum is weakened.
{"title":"Studies of the Origin and Nature of the Energetic Forces Exerted on a Torsion Pendulum by Human Subjects","authors":"J. N. Hansen","doi":"10.53043/2347-3894.acam90037","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90037","url":null,"abstract":"These results extend what is known about the effects of a human subject sitting under a torsion pendulum. Previous results showed that subjects affected the pendulum in significant ways. Substantial shifts of the center of oscillation of the pendulum, shifts as large as 2.2 cm (7 deg) requiring a force that is equivalent to 45 mg were observed. Many new frequencies of oscillation of the pendulum were introduced when a subject was present. Dramatic changes in the amplitudes of oscillation of the pendulum were observed throughout the experiments; increasing, decreasing, and increasing again, in quasi-consistent patterns. These shifts of the center of oscillation, the new frequencies of oscillation, and the changes in amplitudes all persisted for 30-60 min after the subject has left the pendulum. These effects have been variously attributed to ‘human bioenergy,’ or to simple cranial heat convection currents. The physical nature of the forces causing these effects remains uncertain. Until now all the experiments we have performed have used ‘control subjects,’ which refers to subjects with no known abilities that would affect the pendulum in unusual ways. In this work, a subject who had 45 years of daily experience with a particular type of meditation ‘sound current meditation’ was recruited. The purpose was to see if different mental states such as a meditative state versus a non-meditative sate, would affect the pendulum differently. These results establish that they are different, both qualitatively and quantitatively, and that the effects by the experienced meditator were significantly different than those routinely seen with ‘control subjects.’ A new kind of experiment was performed by having subjects sit beside the pendulum instead of directly under it. Subjects were the ‘experienced meditator,’ and a ‘control subject.’ Effects on the pendulum with subjects sitting beside the pendulum were diminished in amplitude but were otherwise similar to subjects sitting directly under the pendulum. Although the possibility of cranial heat convection currents being able to exert these effects from a significant distance is not eliminated, the argument that cranial heat convection currents are solely responsible for subject effects on the pendulum is weakened.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43047389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.53043/2347-3894.acam90035
A. C. Viana Valle, A. Carvalho, Hilana dos Santos Sena Brunel, Maria Tereza de Oliveira
Ruta graveolens belongs to the family Rutaceae, and it is used to treat inflammatory diseases and some cases of cancer due to its anti-inflammatory and analgesic properties. Osteosarcoma (OS) is a bone cancer that mainly affects children and adolescents and has a high index in dogs. The treatment of this cancer consists of high doses of chemotherapy, and resection of the area affected by cancer, thus making it a painful and invasive treatment for patients. Under this perspective, it is necessary to search for new forms of treatment that are less invasive and, at the same time, effective, considering that homeopathy is used as a complementary therapy and benefits the patient's quality of life. This study aimed to compare the in vitro action of the homeopathic medicine Ruta D35 on U2OS osteosarcoma cells and canine mesenchymal stem cells (MSC). Our results demonstrate that Ruta D35 has a toxic effect on U2OS cells (IC50 16.38µL/mL), reducing cell viability compared to MSC (IC50 67.38µL/mL). Therefore, Ruta D35 showed positive results in treating the OS U2OS line, demonstrating a potential activity in treating this cancer.
{"title":"Ruta Graveolens in Homeopathic Dilution Has In Vitro Antitumor Activity in Osteosarcoma Cells (U2OS) and Low Effect on Canine Mesenchymal Stem Cells (CTM)","authors":"A. C. Viana Valle, A. Carvalho, Hilana dos Santos Sena Brunel, Maria Tereza de Oliveira","doi":"10.53043/2347-3894.acam90035","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90035","url":null,"abstract":"Ruta graveolens belongs to the family Rutaceae, and it is used to treat inflammatory diseases and some cases of cancer due to its anti-inflammatory and analgesic properties. Osteosarcoma (OS) is a bone cancer that mainly affects children and adolescents and has a high index in dogs. The treatment of this cancer consists of high doses of chemotherapy, and resection of the area affected by cancer, thus making it a painful and invasive treatment for patients. Under this perspective, it is necessary to search for new forms of treatment that are less invasive and, at the same time, effective, considering that homeopathy is used as a complementary therapy and benefits the patient's quality of life. This study aimed to compare the in vitro action of the homeopathic medicine Ruta D35 on U2OS osteosarcoma cells and canine mesenchymal stem cells (MSC). Our results demonstrate that Ruta D35 has a toxic effect on U2OS cells (IC50 16.38µL/mL), reducing cell viability compared to MSC (IC50 67.38µL/mL). Therefore, Ruta D35 showed positive results in treating the OS U2OS line, demonstrating a potential activity in treating this cancer.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49474413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.53043/2347-3894.acam90038
S. Kolhe, S. Yewale, P. Kolsure, S. Dhavale, S. Padmanabhan
The present work is aimed to develop and validate a reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Scopoletin, Bacopaside-II, Bacopasaponin-C, Withanolide-A, and Withanoside-IV in a proprietary polyherbal formulation containing Bacopa monnieri (Brahmi), Convolvulus pluricaulis (Shankhapushpi), Withania somnifera (Ashwagandha), Nardostachys jatamansi (Jatamansi), Myristica fragrans (Jatiphal) and Valeriana wallichii (Tagar) extracts intended for the treatment of insomnia. The HPLC analysis was performed on a Inertsil ODS, 3V, 250 x 4.6 mm x 5µm, C18 column using 0.1% orthophosphoric acid buffer as the mobile phase (solvent A) and acetonitrile (solvent B) with the gradient: 0-5 min, 10-20% B; 5-10 min, 20-30% B; 10-25 min, 30% B; 25-30 min, 30-40% B; 30-40 min, 40% B; 40-45 min, 40-60% B; 45-48 min, 60% B; 48-50 min, 60-30% B; 50-52 min, 30-10% B and 52-55 min, 10% B at a flow rate of 0.8 ml/min. The detection wavelength was chosen at 227 nm for Withanoside-IV and Withanolide-A, for Scopoletin, Bacopaside-II and Bacopasaponin C, it was 205 nm. The HPLC method was validated as per ICH guidelines for linearity, LOD and LOQ. The calibration curve of all the five phytomarkers showed excellent linear correlation coefficients with values (r2=0.996) for Scopoletin, (r2=0.995) for Withanoside-IV, (r2=0.996) for Withanolide-A, (r2=0.996) for Bacopaside-II and (r2=0.999) for Bacopasaponin-C. Limits of detection (LOD) were 0.04, 0.43, 0.35, 0.39 and 0.18 μg/ml and limits of quantification (LOQ) were 0.12, 1.29, 1.06, 1.18 and 0.54 μg/ml for Scopoletin, Withanoside-IV, Withanolide-A, Bacopaside-II and Bacopasaponin-C respectively. The developed HPLC method showed good separation of all the five constituents, enabling efficient analysis of Scopoletin, Withanoside-IV, Withanolide-A, Bacopaside-II, and Bacopasaponin-C in the polyherbal formulation
{"title":"Simultaneous Estimation of Scopoletin, Bacopaside-II, Bacopasaponin-C, Withanolide-A, and Withanoside-IV in a Clinically Proven Polyherbal Formulation for Treatment of Insomnia","authors":"S. Kolhe, S. Yewale, P. Kolsure, S. Dhavale, S. Padmanabhan","doi":"10.53043/2347-3894.acam90038","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90038","url":null,"abstract":"The present work is aimed to develop and validate a reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Scopoletin, Bacopaside-II, Bacopasaponin-C, Withanolide-A, and Withanoside-IV in a proprietary polyherbal formulation containing Bacopa monnieri (Brahmi), Convolvulus pluricaulis (Shankhapushpi), Withania somnifera (Ashwagandha), Nardostachys jatamansi (Jatamansi), Myristica fragrans (Jatiphal) and Valeriana wallichii (Tagar) extracts intended for the treatment of insomnia. The HPLC analysis was performed on a Inertsil ODS, 3V, 250 x 4.6 mm x 5µm, C18 column using 0.1% orthophosphoric acid buffer as the mobile phase (solvent A) and acetonitrile (solvent B) with the gradient: 0-5 min, 10-20% B; 5-10 min, 20-30% B; 10-25 min, 30% B; 25-30 min, 30-40% B; 30-40 min, 40% B; 40-45 min, 40-60% B; 45-48 min, 60% B; 48-50 min, 60-30% B; 50-52 min, 30-10% B and 52-55 min, 10% B at a flow rate of 0.8 ml/min. The detection wavelength was chosen at 227 nm for Withanoside-IV and Withanolide-A, for Scopoletin, Bacopaside-II and Bacopasaponin C, it was 205 nm. The HPLC method was validated as per ICH guidelines for linearity, LOD and LOQ. The calibration curve of all the five phytomarkers showed excellent linear correlation coefficients with values (r2=0.996) for Scopoletin, (r2=0.995) for Withanoside-IV, (r2=0.996) for Withanolide-A, (r2=0.996) for Bacopaside-II and (r2=0.999) for Bacopasaponin-C. Limits of detection (LOD) were 0.04, 0.43, 0.35, 0.39 and 0.18 μg/ml and limits of quantification (LOQ) were 0.12, 1.29, 1.06, 1.18 and 0.54 μg/ml for Scopoletin, Withanoside-IV, Withanolide-A, Bacopaside-II and Bacopasaponin-C respectively. The developed HPLC method showed good separation of all the five constituents, enabling efficient analysis of Scopoletin, Withanoside-IV, Withanolide-A, Bacopaside-II, and Bacopasaponin-C in the polyherbal formulation","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42228427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.53043/2347-3894.acam90029
A. P. Tarigan, P. Pandia, Agi Hidjri Tarigan, P. Eyanoer
One of the most common problems found in Chronic Pulmonary Obstructive Disease (COPD) patients is decreased tolerance to physical exercises, which increases the mortality rate and the frequency of hospitalization due to the weakening of respiratory function. This condition also leads to weak periphery and respiratory muscles. Pulmonary rehabilitation is the foundational treatment for COPD patients that can improve their training capacity, health-related quality of life and reduce the use of health-care facilities. In compliance with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2022 nonpharmacological initiative for COPD, patients are recommended to do physical activities within their capabilities, while observing physical distancing as a protective measure during the Coronavirus Disease 2019 (Covid-19) pandemic. Pulmonary telerehabilitation presents a feasible solution to overcome the obstacles faced by the healthcare industry to provide in-house rehabilitation programme at hospitals or other health centres. Therefore, it is our objective to study and evaluate the benefits and effectiveness of home-based pulmonary rehabilitation (HBPR).
{"title":"Short Review on Effectiveness of Upper Limb Exercises and Breathing Exercises in COPD Stable Patients During COVID-19 Pandemic Era","authors":"A. P. Tarigan, P. Pandia, Agi Hidjri Tarigan, P. Eyanoer","doi":"10.53043/2347-3894.acam90029","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90029","url":null,"abstract":"One of the most common problems found in Chronic Pulmonary Obstructive Disease (COPD) patients is decreased tolerance to physical exercises, which increases the mortality rate and the frequency of hospitalization due to the weakening of respiratory function. This condition also leads to weak periphery and respiratory muscles. Pulmonary rehabilitation is the foundational treatment for COPD patients that can improve their training capacity, health-related quality of life and reduce the use of health-care facilities. In compliance with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2022 nonpharmacological initiative for COPD, patients are recommended to do physical activities within their capabilities, while observing physical distancing as a protective measure during the Coronavirus Disease 2019 (Covid-19) pandemic. Pulmonary telerehabilitation presents a feasible solution to overcome the obstacles faced by the healthcare industry to provide in-house rehabilitation programme at hospitals or other health centres. Therefore, it is our objective to study and evaluate the benefits and effectiveness of home-based pulmonary rehabilitation (HBPR).","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42870824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.53043/2347-3894.acam90031
Mary G. Sayler
{"title":"Integrating Complementary Therapy into a Pain Management Program on a Transitional Care Unit","authors":"Mary G. Sayler","doi":"10.53043/2347-3894.acam90031","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90031","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47966275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.53043/2347-3894.acam90030
Shuting Chang
{"title":"Short Review on Mushrooms and Their Utilization As Nutritional Supplements","authors":"Shuting Chang","doi":"10.53043/2347-3894.acam90030","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90030","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43959383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.53043/2347-3894.acam90032
Lassi A. Liikkanen
{"title":"http://www.acamjournal.com/open-access/mindful-sauna-practice-alleviates-allergic-symptoms-412.pdf","authors":"Lassi A. Liikkanen","doi":"10.53043/2347-3894.acam90032","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90032","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46145064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.53043/2347-3894.acam90034
A. Casini, R. Vaccaro, Giorgio Vivacqua, P. Onori, E. Gaudio, R. Mancinelli
{"title":"Tracking the Importance of Enteric a-syn Pathology in Parkinson’s Disease","authors":"A. Casini, R. Vaccaro, Giorgio Vivacqua, P. Onori, E. Gaudio, R. Mancinelli","doi":"10.53043/2347-3894.acam90034","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90034","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47071600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}