Pub Date : 2022-03-07DOI: 10.53043/2347-3894.acam90024
Zhenyou Yang, Shuo Zhang, Yujia Tang, Sai Zhang, S. Yue, Qi-Ling Liu
Backgrounds: Since the outbreak of new coronavirus pneumonia worldwide, there are no specific drugs up to now. In people’s struggle with the disease, more and more clinical practice shows that traditional Chinese medicine has shown an increasingly important role in the outbreak. Among them, Qingfei Paidu decoction (QFPD) has been widely used in China and overseas Chinese, which has good advantages in the treatment of COVID-19. Although some meta-analyses have studied the efficacy of QFPD in the treatment of COVID-19, the inclusion and exclusion criteria of trials in these studies were not strict enough and their results were not consistent. So, the exact efficacy of QFPD for treating COVID-19 was still questionable. Objective: To systematically evaluate the efficacy and safety of QFPD for COVID-19. Methods: A comprehensive literature search of qualified trials using QFPD to treat COVID-19 was conducted in 11 electronic databases, including Medline, Embase, Cochrane Library, PubMed, Web of Science, Springer link, Clinicaltrials.gov, etc. From their establishment to March 1, 2021. Subjects and abstracts of the trials were read in Note Express for preliminary screening, and the full text was read for further screening. Researchers independently extracted the data in duplicate, and the risk of bias of trials was assessed by using the Cochrane collaboration tool, followed by data analysis using Rev Man 5.3. Results: Four trials with 390 participants were included for meta-analysis, revealing that QFPD can effectively shorten the average length of stay in hospital and the time of nucleic acid to turn negative. In terms of adverse reactions, there was no significant difference between the experimental and control groups. Conclusions: These results demonstrated that QFPD could effectively treat COVID-19, improve clinical symptoms, shorten hospital stay and nucleic acid negative time, and no obvious adverse reactions have been found. Compared with other meta-analyses of QFPD, this research has some unique features, including its comprehensiveness, the large-scale of its search and its transparent approach, which may provide some new treatment ideas for clinicians. Keywords: Qingfei Paidu decoction; COVID-19; 2019-NcoV; Systematic review; Meta-analysis
背景：新型冠状病毒肺炎疫情在全球范围内爆发以来，至今尚无特效药。在人们与疾病的斗争中，越来越多的临床实践表明，中医药在疫情中发挥着越来越重要的作用。其中清肺排毒汤已在国内外广泛应用，在治疗新冠肺炎方面具有良好优势。尽管一些荟萃分析研究了QFPD治疗新冠肺炎的疗效，但这些研究中试验的纳入和排除标准不够严格，结果也不一致。因此，QFPD治疗新冠肺炎的确切疗效仍然值得怀疑。目的：系统评价QFPD治疗新冠肺炎的疗效和安全性。方法：从建立到2021年3月1日，在Medline、Embase、Cochrane Library、PubMed、Web of Science、Springer link、Clinicaltrials.gov等11个电子数据库中对QFPD治疗新冠肺炎的合格试验进行全面文献检索。受试者和试验摘要在Note Express中阅读以进行初步筛选，全文阅读以进行进一步筛选。研究人员独立提取了一式两份的数据，并使用Cochrane协作工具评估了试验偏倚的风险，然后使用Rev Man 5.3进行数据分析。结果：纳入了4项试验，共390名参与者进行荟萃分析，结果表明QFPD可以有效缩短平均住院时间和核酸转阴时间。在不良反应方面，实验组和对照组之间没有显著差异。结论：QFPD能有效治疗新冠肺炎，改善临床症状，缩短住院时间和核酸阴性时间，未见明显不良反应。与其他QFPD的荟萃分析相比，本研究具有一些独特的特点，包括其全面性、大规模的搜索和透明的方法，这可能为临床医生提供一些新的治疗思路。关键词：清肺排毒汤；2019冠状病毒疾病2019新型冠状病毒系统评审；Meta分析
{"title":"Efficacy and Safety of Qingfei Paidu Decoction for Patients with COVID-19: A Systematic Review and Meta-Analysis","authors":"Zhenyou Yang, Shuo Zhang, Yujia Tang, Sai Zhang, S. Yue, Qi-Ling Liu","doi":"10.53043/2347-3894.acam90024","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90024","url":null,"abstract":"Backgrounds: Since the outbreak of new coronavirus pneumonia worldwide, there are no specific drugs up to now. In people’s struggle with the disease, more and more clinical practice shows that traditional Chinese medicine has shown an increasingly important role in the outbreak. Among them, Qingfei Paidu decoction (QFPD) has been widely used in China and overseas Chinese, which has good advantages in the treatment of COVID-19. Although some meta-analyses have studied the efficacy of QFPD in the treatment of COVID-19, the inclusion and exclusion criteria of trials in these studies were not strict enough and their results were not consistent. So, the exact efficacy of QFPD for treating COVID-19 was still questionable. Objective: To systematically evaluate the efficacy and safety of QFPD for COVID-19. Methods: A comprehensive literature search of qualified trials using QFPD to treat COVID-19 was conducted in 11 electronic databases, including Medline, Embase, Cochrane Library, PubMed, Web of Science, Springer link, Clinicaltrials.gov, etc. From their establishment to March 1, 2021. Subjects and abstracts of the trials were read in Note Express for preliminary screening, and the full text was read for further screening. Researchers independently extracted the data in duplicate, and the risk of bias of trials was assessed by using the Cochrane collaboration tool, followed by data analysis using Rev Man 5.3. Results: Four trials with 390 participants were included for meta-analysis, revealing that QFPD can effectively shorten the average length of stay in hospital and the time of nucleic acid to turn negative. In terms of adverse reactions, there was no significant difference between the experimental and control groups. Conclusions: These results demonstrated that QFPD could effectively treat COVID-19, improve clinical symptoms, shorten hospital stay and nucleic acid negative time, and no obvious adverse reactions have been found. Compared with other meta-analyses of QFPD, this research has some unique features, including its comprehensiveness, the large-scale of its search and its transparent approach, which may provide some new treatment ideas for clinicians. Keywords: Qingfei Paidu decoction; COVID-19; 2019-NcoV; Systematic review; Meta-analysis","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42986641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.53043/2347-3894.acam90022
Yanfang Meng
{"title":"Tribotronic Planar Graphene Transistors for low-energy-consumption high/low frequent stimuli monitoring","authors":"Yanfang Meng","doi":"10.53043/2347-3894.acam90022","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90022","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44772666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.53043/2347-3894.acam90025
S. Choe, S. Aum, Ju Han Kim
Systematic reviews (SRs) have been recognized as the most rigorous and reliable approach to enable evidence-based medicine. However, the considerable workload required to create SRs prevents reflecting the latest knowledge. This study automated the classification of included articles by adopting the Bidirectional Encoder Representations from Transformers (BERT) algorithm. By pretraining with abstracts of articles and a generated vocabulary fine-tuned with titles of articles, the proposed srBERTmy overcomes the training data insufficiency while improving performance in both classification and relation-extraction tasks. Despite the limitation of model vulnerabilities based on training dataset quality, the results demonstrated the feasibility of automatic article classification using machine-learning (ML) approaches to support SR tasks Keywords: Systematic review, process automation, deep learning, text mining
{"title":"Short Review on srBERT: Automatic Article Classification Model for Systematic Review Using BERT","authors":"S. Choe, S. Aum, Ju Han Kim","doi":"10.53043/2347-3894.acam90025","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90025","url":null,"abstract":"Systematic reviews (SRs) have been recognized as the most rigorous and reliable approach to enable evidence-based medicine. However, the considerable workload required to create SRs prevents reflecting the latest knowledge. This study automated the classification of included articles by adopting the Bidirectional Encoder Representations from Transformers (BERT) algorithm. By pretraining with abstracts of articles and a generated vocabulary fine-tuned with titles of articles, the proposed srBERTmy overcomes the training data insufficiency while improving performance in both classification and relation-extraction tasks. Despite the limitation of model vulnerabilities based on training dataset quality, the results demonstrated the feasibility of automatic article classification using machine-learning (ML) approaches to support SR tasks Keywords: Systematic review, process automation, deep learning, text mining","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41595843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.53043/2347-3894.acam90021
Giles Dawnay
{"title":"Commentary on Ill Feelings","authors":"Giles Dawnay","doi":"10.53043/2347-3894.acam90021","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90021","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43274647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.53043/2347-3894.acam90023
Liang Zhou, M. Li
{"title":"Caspase-8 Inhibitor Enhances the Anti-Myeloma Effect of Lenalidomide and Bortezomib","authors":"Liang Zhou, M. Li","doi":"10.53043/2347-3894.acam90023","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90023","url":null,"abstract":"","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49286657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.53043/2347-3894.acam90027
D. Aklilu, Zhiwei Li, Tianqi Wang, W. Feng, Xia Li, Lixin Tao, Wen Wang, M. Guo, Yanshuang Jiang, Anteneh Tamirat, Xiangtong Liu, Xiuhua Guo
Background: Acute effects of metrological factors on cerebrovascular diseases (CBVD) have become a growing public health concern. However, the impact of those factors on CBVD among type 2 diabetes (T2D) patients has not been well studied in the study area. The main aim of this study was to assess the acute effects of metrological factors including temperature, relative humidity and atmospheric pressure on incidence of CBVD among type 2 diabetes patients in Beijing, China. Methods: Data was obtained from 258 large general hospitals from the Beijing Public Health Information Center Cardiovascular Case Database and China. Meteorological Administration covering 16 districts in Beijing from 2014 to 2018. Time-stratified case crossover design with a distributed lag nonlinear model (DLNM) was used by considering 27 lag days on CBVD admissions. Results: Within five years (January 2014–December 2018), a total of 223,216 cases for cerebrovascular disease were collected after excluding nonlocal admissions, of which 9,541 (4.27%), 149,757 (67.09%), 7,444 (3.33%), 31,356 (14.05%), and 23,912 (10.71%) were hospitalized for hemorrhagic stroke, ischemic stroke, atherosclerosis, intracranial aneurysm, and apoplexy sequela, respectively. In short, male participants and elderly individuals (≥65 years) accounted for 57.6% and 61.7%, respectively. Generally, the cumulative exposure-response curve for temperature was almost inverted “V”-shaped, with a slight increase at concentrations of higher than 25°C. The cumulative exposure response curve for relative humidity was almost linear. The cumulative exposure-response curves for atmospheric pressure were V-shaped, which meant that both high and low concentrations of atmospheric pressure may increase the risk of cerebrovascular disease incidence among patients with T2D. Conclusions: The results of this study indicate that both an increase and a decrease in temperature and atmospheric pressure had a significant association with the occurrence of cerebrovascular disease among co morbid patients with diabetes. This study provides evidence of the short term effects of metrological factors on hospital admissions of CBVD among T2D patients. Keywords: Keywords: Admission; Beijing; Cerebrovascular disease; Distributed lag nonlinear model; Metrological factors, Type 2 diabetes
{"title":"Acute Effects of Metrological Factors on Cerebrovascular Diseases among Type2 Diabetes Patients: case crossover evidence from Beijing, China","authors":"D. Aklilu, Zhiwei Li, Tianqi Wang, W. Feng, Xia Li, Lixin Tao, Wen Wang, M. Guo, Yanshuang Jiang, Anteneh Tamirat, Xiangtong Liu, Xiuhua Guo","doi":"10.53043/2347-3894.acam90027","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90027","url":null,"abstract":"Background: Acute effects of metrological factors on cerebrovascular diseases (CBVD) have become a growing public health concern. However, the impact of those factors on CBVD among type 2 diabetes (T2D) patients has not been well studied in the study area. The main aim of this study was to assess the acute effects of metrological factors including temperature, relative humidity and atmospheric pressure on incidence of CBVD among type 2 diabetes patients in Beijing, China. Methods: Data was obtained from 258 large general hospitals from the Beijing Public Health Information Center Cardiovascular Case Database and China. Meteorological Administration covering 16 districts in Beijing from 2014 to 2018. Time-stratified case crossover design with a distributed lag nonlinear model (DLNM) was used by considering 27 lag days on CBVD admissions. Results: Within five years (January 2014–December 2018), a total of 223,216 cases for cerebrovascular disease were collected after excluding nonlocal admissions, of which 9,541 (4.27%), 149,757 (67.09%), 7,444 (3.33%), 31,356 (14.05%), and 23,912 (10.71%) were hospitalized for hemorrhagic stroke, ischemic stroke, atherosclerosis, intracranial aneurysm, and apoplexy sequela, respectively. In short, male participants and elderly individuals (≥65 years) accounted for 57.6% and 61.7%, respectively. Generally, the cumulative exposure-response curve for temperature was almost inverted “V”-shaped, with a slight increase at concentrations of higher than 25°C. The cumulative exposure response curve for relative humidity was almost linear. The cumulative exposure-response curves for atmospheric pressure were V-shaped, which meant that both high and low concentrations of atmospheric pressure may increase the risk of cerebrovascular disease incidence among patients with T2D. Conclusions: The results of this study indicate that both an increase and a decrease in temperature and atmospheric pressure had a significant association with the occurrence of cerebrovascular disease among co morbid patients with diabetes. This study provides evidence of the short term effects of metrological factors on hospital admissions of CBVD among T2D patients. Keywords: Keywords: Admission; Beijing; Cerebrovascular disease; Distributed lag nonlinear model; Metrological factors, Type 2 diabetes","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47209513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-24DOI: 10.53043/2347-3894.acam90020
Yan Luo, Sizhe Gao, Jun Cheng, Weijian Xiong, Wenyue Cao
Lianhuaqingwen (LH) is the widely used in the treatment of Coronavirus disease 2019 (COVID-19). However, its mechanisms of action and molecular targets for treatment of COVID-19 are not clear. The active compounds of LH were collected and their targets were identified through the network pharmacology. The mechanism of compound multi components and multi targets and its relationship with disease are analyzed. COVID-19 targets were obtained by analyzing with TCMSP. In total, 282 active ingredients and 510 targets of LH were identified. Twenty-one target genes associated with LH and COVID-19. Protein-protein interaction (PPI) data were then obtained and PPI networks of LH putative targets and COVID-19-related targets were visualized and merged to identify the candidate targets for LH against COVID-19. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis were carried out. The gene-pathway network was constructed to screen the crucial target genes. The functional annotations of target genes were found to be related to immune regulation, host defense, inflammatory reaction and autoimmune diseases and so on. Twenty pathways including immunology, cancer, and cell processing were significantly enriched. Quercetin and luteolin might be the crucial ingredients. IL6 was the core gene and other several genes including IL1B, STAT1, IFNGR1, and NCF1 were the key genes in the gene-pathway network of LH for treatment of COVID-19. The results indicated that LH’s effects against COVID-19 might relate to regulation of immunological function through the specific biological processes and the related pathways. This study demonstrates the application of network pharmacology in evaluating mechanisms of action and molecular targets of complex herbal formulations.
{"title":"Elucidation of the Mechanisms and Molecular Targets of Lianhuaqingwen for Treatment of COVID-19 Based on Network Pharmacology","authors":"Yan Luo, Sizhe Gao, Jun Cheng, Weijian Xiong, Wenyue Cao","doi":"10.53043/2347-3894.acam90020","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90020","url":null,"abstract":"Lianhuaqingwen (LH) is the widely used in the treatment of Coronavirus disease 2019 (COVID-19). However, its mechanisms of action and molecular targets for treatment of COVID-19 are not clear. The active compounds of LH were collected and their targets were identified through the network pharmacology. The mechanism of compound multi components and multi targets and its relationship with disease are analyzed. COVID-19 targets were obtained by analyzing with TCMSP. In total, 282 active ingredients and 510 targets of LH were identified. Twenty-one target genes associated with LH and COVID-19. Protein-protein interaction (PPI) data were then obtained and PPI networks of LH putative targets and COVID-19-related targets were visualized and merged to identify the candidate targets for LH against COVID-19. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis were carried out. The gene-pathway network was constructed to screen the crucial target genes. The functional annotations of target genes were found to be related to immune regulation, host defense, inflammatory reaction and autoimmune diseases and so on. Twenty pathways including immunology, cancer, and cell processing were significantly enriched. Quercetin and luteolin might be the crucial ingredients. IL6 was the core gene and other several genes including IL1B, STAT1, IFNGR1, and NCF1 were the key genes in the gene-pathway network of LH for treatment of COVID-19. The results indicated that LH’s effects against COVID-19 might relate to regulation of immunological function through the specific biological processes and the related pathways. This study demonstrates the application of network pharmacology in evaluating mechanisms of action and molecular targets of complex herbal formulations.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48228358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-22DOI: 10.53043/2347-3894.acam90018
un Yuan Qin, Wenxue Liu, Xiaohui Xie, P. Cheng
Scutellariae (Huangqin) is a traditional medicine that is widely applied in China for the treatment of cold and fever, and nowadays research found that it can against pathogenic microorganism. Flavonoids is the main active constituent isolated from Scutellariae and possesses outstanding antibiosis activity. Scutellaria flavonoids displayed antiseptic actions and anti-resistance, including but not limited to destroy bacterial biofilm, suppressed activity of the DNA enzyme, restrain efflux pump and quorum-sensing system. This paper highlights and discusses the antibiosis activity of Scutellaria flavonoids, along with possible mechanisms of its action. hoping to providing basis and evidence for clinical application.
{"title":"Research Progress on Antibiosis Activity of Scutellaria Flavonoids","authors":"un Yuan Qin, Wenxue Liu, Xiaohui Xie, P. Cheng","doi":"10.53043/2347-3894.acam90018","DOIUrl":"https://doi.org/10.53043/2347-3894.acam90018","url":null,"abstract":"Scutellariae (Huangqin) is a traditional medicine that is widely applied in China for the treatment of cold and fever, and nowadays research found that it can against pathogenic microorganism. Flavonoids is the main active constituent isolated from Scutellariae and possesses outstanding antibiosis activity. Scutellaria flavonoids displayed antiseptic actions and anti-resistance, including but not limited to destroy bacterial biofilm, suppressed activity of the DNA enzyme, restrain efflux pump and quorum-sensing system. This paper highlights and discusses the antibiosis activity of Scutellaria flavonoids, along with possible mechanisms of its action. hoping to providing basis and evidence for clinical application.","PeriodicalId":72312,"journal":{"name":"Asian journal of complementary and alternative medicine : A-CAM","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41486090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.53043/2347-3894.acam90014
A. Valle, L. R. Aguiar, H. Brunel, P. Malard, R. Andrade
Background: Viscum album (VA) extracts have a wide variety of biologically active compounds that can be used in the treatment of various diseases, with cancer being the main one. However, few data on the effects of homeopathic VA are found in the literature, even though commercially VA formulations are available, with extremely low doses of its active compounds. Previous studies used the anthroposophical form of Viscum and provided information on the mechanisms of action of this drug in tumor cells or in cells of the immune system. Materials and methods: This study aimed to evaluate the safety of intravenous and subcutaneous application of D3 homeopathic Viscum album (VAD3) in dogs. Healthy dogs (n=7) underwent blood collection for blood cells count and biochemistry analysis and clinical examinations 7 days prior and at days 0, 3, 5, 7, 10, 12, and 14 after the beginning of treatment. The dogs received intravenous application of VAD3 at days 0, 5, 10, and 14, and subcutaneous at days 3, 7, and 12. Results: There was a transient increase in the number of monocytes (P=0.0022) at day 5, while there were no significant (P>0.05) changes in any of the other blood endpoints over time. Nevertheless, all blood parameters remained within the reference values for the species. All animals completed the study in good health conditions. According to the Quality-of-Life Assessment Questionnaire, all animals showed improvement in mood and appetite after receiving VAD3. Conclusion: The homeopathic medicine VAD3 is safe for intravenous and subcutaneous applications in dogs, besides possibly bringing benefits to the entire organism.
背景:Viscum album (VA)提取物具有多种生物活性化合物，可用于治疗多种疾病，以癌症为主要治疗对象。然而，在文献中很少发现顺势疗法VA的效果数据，即使商业VA配方可用，其活性化合物的剂量极低。先前的研究使用了人智学形式的Viscum，并提供了该药物在肿瘤细胞或免疫系统细胞中的作用机制的信息。材料与方法:本研究旨在评价D3顺势疗法Viscum album (VAD3)在犬体内静脉和皮下应用的安全性。健康犬(n=7)在治疗前7天和治疗开始后第0、3、5、7、10、12和14天采血进行血细胞计数、生化分析和临床检查。在第0、5、10和14天静脉注射VAD3，在第3、7和12天皮下注射。结果:第5天单核细胞数量短暂增加(P=0.0022)，而其他任何血液终点随着时间的推移均无显著变化(P < 0.05)。尽管如此，所有血液参数仍在参考值范围内。所有动物在良好的健康状况下完成了研究。根据生活质量评估问卷，所有动物在接受VAD3后情绪和食欲都有所改善。结论:顺势疗法药物VAD3在犬体内静脉和皮下应用是安全的，并可能对整个机体产生益处。
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