Biological psychiatry global open science最新文献

英文中文

In This Issue – November 本期内容 - 十一月

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsgos.2024.100403

引用次数: 0

Guide for Authors 作者指南

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-11-01 DOI: 10.1016/S2667-1743(24)00123-X

引用次数: 0

Subscribers Page 订阅者页面

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-11-01 DOI: 10.1016/S2667-1743(24)00121-6

引用次数: 0

Editorial Board Page 编辑委员会页面

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-11-01 DOI: 10.1016/S2667-1743(24)00120-4

引用次数: 0

Acknowledgments 致谢

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-11-01 DOI: 10.1016/j.bpsgos.2024.100404

引用次数: 0

Psychobiological Stress Response Profiles in Current and Remitted Depression: A Person-Centered, Multisystem Approach 当前和缓解期抑郁症的心理生物学压力反应特征：以人为本的多系统方法

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-10-09 DOI: 10.1016/j.bpsgos.2024.100400

Manuel Kuhn , David C. Steinberger , Jason José Bendezú , Maria Ironside , Min S. Kang , Kaylee E. Null , Devon L. Brunner , Diego A. Pizzagalli

Background

A dysregulated stress response, including exaggerated affective reactivity and abnormal hypothalamic-pituitary-adrenal axis responsivity, has been implicated in the etiology, maintenance, and relapse of major depressive disorder (MDD). Among adolescents, discordant affective and physiological stress response profiles have been linked to negative affective outcomes and increased risk for psychopathology. Whether these findings extend to adults with varying degree of MDD risk is unclear, as are possible links to various risk factors.

Methods

We used a person-centered, multisystem approach in a sample of 119 unmedicated adults with current or remitted MDD and individuals without past MDD to evaluate psychobiological stress response profiles. Multitrajectory modeling was applied to positive affect, negative affect, and salivary cortisol (CORT) levels in response to the Maastricht Acute Stress Test.

Results

Analyses identified 4 within-person profiles, 1 typical, termed normative (n = 32, 26.9%) and 3 atypical: CORT hyperreactivity affective stability (n = 17, 14.3%), CORT hyporeactivity affective reactivity 1 (n = 45, 37.8%), and CORT hyporeactivity affective reactivity 2 (n = 25, 21.0%). While validating the assumption of a normative profile and increased risk for psychopathology in non-normative stress response profiles, coherent associations emerged between stress response profiles and clinical status, depression severity, anhedonia, perceived stress, childhood adversity, and reports of well-being, suggesting increased risk for psychopathology for individuals with a hyperreactive or discordant hyporeactive stress response profile.

Conclusions

This work advances our understanding of stress response mechanisms in MDD and underscores the potential of targeted interventions to enhance resilience and reduce psychopathology based on individual stress response profiles.

背景应激反应失调，包括情感反应性过强和下丘脑-垂体-肾上腺轴反应性异常，已被认为与重度抑郁障碍（MDD）的病因、维持和复发有关。在青少年中，不和谐的情感和生理压力反应特征与负面情感结果和精神病理学风险增加有关。这些研究结果是否适用于具有不同程度 MDD 风险的成年人，以及与各种风险因素之间可能存在的联系，目前尚不清楚。研究方法：我们采用以人为本的多系统方法，对 119 名当前或缓解的 MDD 未服药成年人以及既往无 MDD 的人进行了抽样调查，以评估心理生物应激反应特征。多轨迹模型适用于积极情绪、消极情绪和唾液皮质醇（CORT）水平对马斯特里赫特急性压力测试的反应：CORT 高反应性情感稳定性（n = 17，14.3%）、CORT 低反应性情感反应性 1（n = 45，37.8%）和 CORT 低反应性情感反应性 2（n = 25，21.0%）。在验证了常模特征假设和非常模应激反应特征的精神病理学风险增加的同时，应激反应特征与临床状态、抑郁严重程度、失乐症、感知压力、童年逆境和幸福感报告之间出现了一致的关联，表明应激反应特征反应过度或不一致的低反应个体的精神病理学风险增加。结论这项研究加深了我们对 MDD 压力反应机制的了解，并强调了根据个体压力反应特征采取针对性干预措施以增强复原力和减少精神病理学的潜力。

{"title":"Psychobiological Stress Response Profiles in Current and Remitted Depression: A Person-Centered, Multisystem Approach","authors":"Manuel Kuhn , David C. Steinberger , Jason José Bendezú , Maria Ironside , Min S. Kang , Kaylee E. Null , Devon L. Brunner , Diego A. Pizzagalli","doi":"10.1016/j.bpsgos.2024.100400","DOIUrl":"10.1016/j.bpsgos.2024.100400","url":null,"abstract":"<div><h3>Background</h3><div>A dysregulated stress response, including exaggerated affective reactivity and abnormal hypothalamic-pituitary-adrenal axis responsivity, has been implicated in the etiology, maintenance, and relapse of major depressive disorder (MDD). Among adolescents, discordant affective and physiological stress response profiles have been linked to negative affective outcomes and increased risk for psychopathology. Whether these findings extend to adults with varying degree of MDD risk is unclear, as are possible links to various risk factors.</div></div><div><h3>Methods</h3><div>We used a person-centered, multisystem approach in a sample of 119 unmedicated adults with current or remitted MDD and individuals without past MDD to evaluate psychobiological stress response profiles. Multitrajectory modeling was applied to positive affect, negative affect, and salivary cortisol (CORT) levels in response to the Maastricht Acute Stress Test.</div></div><div><h3>Results</h3><div>Analyses identified 4 within-person profiles, 1 typical, termed normative (<em>n</em> = 32, 26.9%) and 3 atypical: CORT hyperreactivity affective stability (<em>n</em> = 17, 14.3%), CORT hyporeactivity affective reactivity 1 (<em>n</em> = 45, 37.8%), and CORT hyporeactivity affective reactivity 2 (<em>n</em> = 25, 21.0%). While validating the assumption of a normative profile and increased risk for psychopathology in non-normative stress response profiles, coherent associations emerged between stress response profiles and clinical status, depression severity, anhedonia, perceived stress, childhood adversity, and reports of well-being, suggesting increased risk for psychopathology for individuals with a hyperreactive or discordant hyporeactive stress response profile.</div></div><div><h3>Conclusions</h3><div>This work advances our understanding of stress response mechanisms in MDD and underscores the potential of targeted interventions to enhance resilience and reduce psychopathology based on individual stress response profiles.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100400"},"PeriodicalIF":4.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice 半自然环境中的群体社会动态反映了雄性小鼠攻击行为的适应价值

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-10-01 DOI: 10.1016/j.bpsgos.2024.100399

Sergey Anpilov , Yair Shemesh , Asaf Benjamin , Tommaso Biagini , Daniil Umanski , Yehonatan Zur , Yehezkel Sztainberg , Alon Richter-Levin , Oren Forkosh , Alon Chen

Background

Maladaptive aggression in humans is associated with several psychiatric conditions and lacks effective treatment. Nevertheless, tightly regulated aggression is essential for survival throughout the animal kingdom. Studying how social dominance hierarchies regulate aggression and access to resources in an enriched environment (EE) can narrow the translational gap between aggression in animal models and normal and pathological human behavior.

Methods

The social box is a seminatural setup for automatic and prolonged monitoring of mouse group dynamics. We utilized the social box to decipher tradeoffs between aggression, social avoidance, resource allocation, and dominance in 2 mouse models of increased aggression: 1) a model of early exposure to an EE and 2) a model of oxytocin receptor deficiency (Oxtr^−/−). While environmental enrichment increases aggression as an adaptive response to external stimuli, hyperaggression in Oxtr^−/− mice is accompanied by marked abnormalities in social behavior.

Results

EE groups exhibited significant social avoidance, and an increased proportion of their encounters developed into aggressive interactions, resulting in lower levels of exploratory activity and overall aggression. The hierarchy in EE groups was more stable than in control groups, and dominance was correlated with access to resources. In Oxtr^−/− groups, mice engaged in excessive social encounters and aggressive chasing, accompanied by increased overall activity. In Oxtr^−/− groups, dominance hierarchies existed but were not correlated with access to resources.

Conclusions

Measuring aggression and social dominance hierarchies in a seminatural setup reveals the adaptive value of aggression in EE and Oxtr^−/− mice. This approach can enhance translational research on pathological aggression.

背景人类的适应性攻击行为与多种精神疾病有关，而且缺乏有效的治疗方法。然而，在整个动物界，受到严格调控的攻击行为对于生存至关重要。研究丰富环境（EE）中社会支配等级如何调节攻击行为和资源获取，可以缩小动物模型中的攻击行为与正常和病态人类行为之间的转化差距。我们利用 "社交箱 "在两种攻击性增加的小鼠模型中解读了攻击性、社会回避、资源分配和支配地位之间的权衡：1）早期暴露于 EE 的模型；2）催产素受体缺乏（Oxtr-/-）的模型。结果EE组小鼠表现出明显的社会回避，而且它们相遇时发展成攻击性互动的比例增加，导致探索活动和整体攻击性水平降低。与对照组相比，EE 组的等级制度更加稳定，支配地位与获得资源的机会相关。在Oxtr-/-组中，小鼠进行了过度的社交接触和攻击性追逐，同时总体活动增加。结论在半自然设置中测量攻击性和社会支配等级揭示了EE和Oxtr-/-小鼠攻击性的适应价值。这种方法可以促进病理性攻击行为的转化研究。

{"title":"Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice","authors":"Sergey Anpilov , Yair Shemesh , Asaf Benjamin , Tommaso Biagini , Daniil Umanski , Yehonatan Zur , Yehezkel Sztainberg , Alon Richter-Levin , Oren Forkosh , Alon Chen","doi":"10.1016/j.bpsgos.2024.100399","DOIUrl":"10.1016/j.bpsgos.2024.100399","url":null,"abstract":"<div><h3>Background</h3><div>Maladaptive aggression in humans is associated with several psychiatric conditions and lacks effective treatment. Nevertheless, tightly regulated aggression is essential for survival throughout the animal kingdom. Studying how social dominance hierarchies regulate aggression and access to resources in an enriched environment (EE) can narrow the translational gap between aggression in animal models and normal and pathological human behavior.</div></div><div><h3>Methods</h3><div>The social box is a seminatural setup for automatic and prolonged monitoring of mouse group dynamics. We utilized the social box to decipher tradeoffs between aggression, social avoidance, resource allocation, and dominance in 2 mouse models of increased aggression: 1) a model of early exposure to an EE and 2) a model of oxytocin receptor deficiency (<em>Oxt</em><em>r</em><sup><em>−/−</em></sup>). While environmental enrichment increases aggression as an adaptive response to external stimuli, hyperaggression in <em>Oxt</em><em>r</em><sup><em>−/−</em></sup> mice is accompanied by marked abnormalities in social behavior.</div></div><div><h3>Results</h3><div>EE groups exhibited significant social avoidance, and an increased proportion of their encounters developed into aggressive interactions, resulting in lower levels of exploratory activity and overall aggression. The hierarchy in EE groups was more stable than in control groups, and dominance was correlated with access to resources. In <em>Oxt</em><em>r</em><sup><em>−/−</em></sup> groups, mice engaged in excessive social encounters and aggressive chasing, accompanied by increased overall activity. In <em>Oxt</em><em>r</em><sup><em>−/−</em></sup> groups, dominance hierarchies existed but were not correlated with access to resources.</div></div><div><h3>Conclusions</h3><div>Measuring aggression and social dominance hierarchies in a seminatural setup reveals the adaptive value of aggression in EE and <em>Oxt</em><em>r</em><sup><em>−/</em>−</sup> mice. This approach can enhance translational research on pathological aggression.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100399"},"PeriodicalIF":4.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of an 18-Month Meditation Training on Telomeres in Older Adults: A Secondary Analysis of the Age-Well Randomized Controlled Trial 为期 18 个月的冥想训练对老年人端粒的影响：年龄-健康随机对照试验的二次分析

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-10-01 DOI: 10.1016/j.bpsgos.2024.100398

Perla Kaliman , María Jesús Álvarez-López , Asrar Lehodey , Daniel Fernández , Anne Chocat , Marco Schlosser , Vincent de La Sayette , Denis Vivien , Natalie L. Marchant , Gael Chételat , Antoine Lutz , Géraldine Poisnel

Background

Shorter telomeres are associated with increased risk of cognitive decline and age-related diseases. Developing interventions to promote healthy aging by preserving telomere integrity is of paramount importance. Here, we investigated the effect of an 18-month meditation intervention on telomere length (TL) measures in older people without cognitive impairment.

Methods

A total of 137 adults age ≥65 years were randomized to one of the 3 groups (meditation training, non-native language training, or passive control). We evaluated the 50th and 20th percentile TL and the percentage of critically short telomeres (<3 kbp) in peripheral blood mononuclear cells.

Results

Mixed model analysis showed a time effect indicating a general decrease on the 50th percentile TL (F = 80.72, p_adjusted < .001), without a significant group effect or time × group interaction. No significant effect was detected in the 20th percentile TL or the percentage of critically short telomeres. Secondary analysis showed that only in the meditation training group 1) the 50th percentile TL positively correlated with class attendance time (r = 0.45, p_adjusted < .011), 2) the 50th and 20th percentile TL positively correlated with responsiveness to the intervention, evaluated through a composite score (r = 0.46, p_adjusted < .010 and r = 0.41, p_adjusted = .029, respectively), and 3) lower scores on a measure of the personality trait “openness to experience” correlated with a lower percentage of critically short telomeres after the intervention (r = 0.44, p_adjusted = .015).

Conclusions

In older adults, we found no evidence for a main effect of an 18-month meditation training program on TL compared with the control groups. Our findings highlight the importance of considering the impact of moderating factors when measuring the effectiveness of meditation-based trainings.

背景端粒变短与认知能力下降和老年相关疾病的风险增加有关。制定干预措施，通过保护端粒完整性来促进健康老龄化至关重要。在此，我们研究了为期18个月的冥想干预对无认知障碍老年人端粒长度（TL）测量的影响。方法：137名年龄≥65岁的成年人被随机分配到3个组（冥想训练组、非母语训练组或被动对照组）中的一组。我们评估了外周血单核细胞中第50和第20百分位数端粒长度和极短端粒（3 kbp）的百分比。结果混合模型分析表明，时间效应表明第50百分位数端粒长度普遍下降（F = 80.72，padjusted <.001），而没有显著的组效应或时间×组交互作用。在第20百分位数端粒长度或极短端粒的百分比方面没有发现明显的影响。二次分析表明，只有在冥想训练组中，1）第 50 位百分位数端粒长度与上课时间呈正相关（r = 0.45，经垫底调整后为 0.011）；2）第 50 位和第 20 位百分位数端粒长度与通过综合评分评估的干预响应度呈正相关（r = 0.46，经垫底调整后为 0.010 和 r = 0.41，经垫底调整后为 0.029）；3）第 50 位和第 20 位百分位数端粒长度与通过综合评分评估的干预响应度呈正相关（r = 0.46，经垫底调整后为 0.010 和 r = 0.41，经垫底调整后为 0.029）。结论在老年人中，与对照组相比，我们没有发现证据表明为期 18 个月的冥想训练计划对端粒寿命有主要影响。我们的研究结果凸显了在衡量冥想训练的有效性时考虑调节因素影响的重要性。

{"title":"Effect of an 18-Month Meditation Training on Telomeres in Older Adults: A Secondary Analysis of the Age-Well Randomized Controlled Trial","authors":"Perla Kaliman , María Jesús Álvarez-López , Asrar Lehodey , Daniel Fernández , Anne Chocat , Marco Schlosser , Vincent de La Sayette , Denis Vivien , Natalie L. Marchant , Gael Chételat , Antoine Lutz , Géraldine Poisnel","doi":"10.1016/j.bpsgos.2024.100398","DOIUrl":"10.1016/j.bpsgos.2024.100398","url":null,"abstract":"<div><h3>Background</h3><div>Shorter telomeres are associated with increased risk of cognitive decline and age-related diseases. Developing interventions to promote healthy aging by preserving telomere integrity is of paramount importance. Here, we investigated the effect of an 18-month meditation intervention on telomere length (TL) measures in older people without cognitive impairment.</div></div><div><h3>Methods</h3><div>A total of 137 adults age ≥65 years were randomized to one of the 3 groups (meditation training, non-native language training, or passive control). We evaluated the 50th and 20th percentile TL and the percentage of critically short telomeres (<3 kbp) in peripheral blood mononuclear cells.</div></div><div><h3>Results</h3><div>Mixed model analysis showed a time effect indicating a general decrease on the 50th percentile TL (<em>F</em> = 80.72, <em>p</em><sub>adjusted</sub> < .001), without a significant group effect or time × group interaction. No significant effect was detected in the 20th percentile TL or the percentage of critically short telomeres. Secondary analysis showed that only in the meditation training group 1) the 50th percentile TL positively correlated with class attendance time (<em>r</em> = 0.45, <em>p</em><sub>adjusted</sub> < .011), 2) the 50th and 20th percentile TL positively correlated with responsiveness to the intervention, evaluated through a composite score (<em>r</em> = 0.46, <em>p</em><sub>adjusted</sub> < .010 and <em>r</em> = 0.41, <em>p</em><sub>adjusted</sub> = .029, respectively), and 3) lower scores on a measure of the personality trait “openness to experience” correlated with a lower percentage of critically short telomeres after the intervention (<em>r</em> = 0.44, <em>p</em><sub>adjusted</sub> = .015).</div></div><div><h3>Conclusions</h3><div>In older adults, we found no evidence for a main effect of an 18-month meditation training program on TL compared with the control groups. Our findings highlight the importance of considering the impact of moderating factors when measuring the effectiveness of meditation-based trainings.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100398"},"PeriodicalIF":4.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Transition From Homogeneous to Heterogeneous Machine Learning in Neuropsychiatric Research 神经精神研究中从同构机器学习到异构机器学习的转变

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-26 DOI: 10.1016/j.bpsgos.2024.100397

Qingyu Zhao , Kate B. Nooner , Susan F. Tapert , Ehsan Adeli , Kilian M. Pohl , Amy Kuceyeski , Mert R. Sabuncu

Despite the advantage of neuroimaging-based machine learning (ML) models as pivotal tools for investigating brain-behavior relationships in neuropsychiatric studies, these data-driven predictive approaches have yet to yield substantial, clinically actionable insights for mental health care. A notable impediment lies in the inadequate accommodation of most ML research to the natural heterogeneity within large samples. Although commonly thought of as individual-level analyses, many ML algorithms are unimodal and homogeneous and thus incapable of capturing the potentially heterogeneous relationships between biology and psychopathology. We review the current landscape of computational research targeting population heterogeneity and argue that there is a need to expand from brain subtyping and behavioral phenotyping to analyses that focus on heterogeneity at the relational level. To this end, we review and suggest several existing ML models with the capacity to discern how external environmental and sociodemographic factors moderate the brain-behavior mapping function in a data-driven fashion. These heterogeneous ML models hold promise for enhancing the discovery of individualized brain-behavior associations and advancing precision psychiatry.

尽管基于神经成像的机器学习（ML）模型作为神经精神研究中调查大脑与行为关系的关键工具具有优势，但这些数据驱动的预测方法尚未为精神健康护理带来实质性的、临床上可操作的见解。一个显著的障碍在于，大多数 ML 研究无法充分适应大型样本中的自然异质性。尽管通常被认为是个体层面的分析，但许多 ML 算法都是单模态和同质的，因此无法捕捉生物学与精神病理学之间潜在的异质性关系。我们回顾了当前针对群体异质性的计算研究，认为有必要从大脑亚型和行为表型扩展到关注关系层面异质性的分析。为此，我们回顾并提出了几种现有的 ML 模型，这些模型有能力以数据驱动的方式辨别外部环境和社会人口因素是如何调节大脑-行为映射功能的。这些异质性 ML 模型有望促进个性化大脑行为关联的发现，并推动精准精神病学的发展。

{"title":"The Transition From Homogeneous to Heterogeneous Machine Learning in Neuropsychiatric Research","authors":"Qingyu Zhao , Kate B. Nooner , Susan F. Tapert , Ehsan Adeli , Kilian M. Pohl , Amy Kuceyeski , Mert R. Sabuncu","doi":"10.1016/j.bpsgos.2024.100397","DOIUrl":"10.1016/j.bpsgos.2024.100397","url":null,"abstract":"<div><div>Despite the advantage of neuroimaging-based machine learning (ML) models as pivotal tools for investigating brain-behavior relationships in neuropsychiatric studies, these data-driven predictive approaches have yet to yield substantial, clinically actionable insights for mental health care. A notable impediment lies in the inadequate accommodation of most ML research to the natural heterogeneity within large samples. Although commonly thought of as individual-level analyses, many ML algorithms are unimodal and homogeneous and thus incapable of capturing the potentially heterogeneous relationships between biology and psychopathology. We review the current landscape of computational research targeting population heterogeneity and argue that there is a need to expand from brain subtyping and behavioral phenotyping to analyses that focus on heterogeneity at the relational level. To this end, we review and suggest several existing ML models with the capacity to discern how external environmental and sociodemographic factors moderate the brain-behavior mapping function in a data-driven fashion. These heterogeneous ML models hold promise for enhancing the discovery of individualized brain-behavior associations and advancing precision psychiatry.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100397"},"PeriodicalIF":4.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraindividual Variability of Event-Related Potentials in Psychosis: A Registered Report 精神病患者事件相关电位的个体内差异性：注册报告

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-21 DOI: 10.1016/j.bpsgos.2024.100396

Amanda Holbrook , Bohyun Park , Philippe Rast , Gregory A. Light , Peter E. Clayson

Background

Neurophysiological tools have yielded valuable insights into the pathophysiology and treatment of psychosis. However, studies using event-related potentials (ERPs) have primarily focused on mean scores and neglected the within-person variability of ERP scores. The neglect of within-person variability of ERPs in the search for biomarkers might have resulted in crucial differences related to psychosis being missed. In this registered report, we aimed to determine whether distinct patterns of intraindividual variability in ERP biomarkers would be observed in people with a lifetime psychosis diagnosis.

Methods

Publicly available data posted to the National Institute of Mental Health Data Archive for 1R01MH110434-01 was obtained for 162 patients with a lifetime history of psychosis and 178 never-psychotic (NP) participants. Participants completed tasks that measured the auditory mismatch negativity (MMN), P300, error-related negativity, and reward positivity. Multilevel location-scale models were used to determine whether patients showed greater intraindividual variability of ERP scores than NP participants.

Results

Contrary to predictions, the groups did not differ in within-person variability of MMN frequency, P300, or error-related negativity; patients showed less variability in MMN duration than NP participants. Exploratory analyses of a subset of patients with schizophrenia showed greater variability of MMN in this group than in the NP group. Greater severity of thought disorder and activation symptoms were associated with higher intraindividual MMN variability.

Conclusions

Distinct patterns of intraindividual variability in the measured ERPs were not observed for the broad group of people with lifetime psychotic disorders. Exploratory analyses suggest that intraindividual differences in ERPs are more relevant to schizophrenia and certain symptom dimensions than to psychotic disorders broadly, but research is needed to confirm these exploratory findings.

背景神经生理学工具为精神病的病理生理学和治疗提供了宝贵的见解。然而，使用事件相关电位（ERPs）进行的研究主要集中在平均得分上，而忽视了ERP得分的人内变异性。在寻找生物标志物的过程中忽视ERP的人内变异性可能会导致与精神病有关的关键差异被遗漏。在这份注册报告中，我们旨在确定在终生被诊断为精神病的人群中是否会观察到ERP生物标志物的个体内变异性的独特模式。方法我们获得了美国国家精神卫生研究所数据档案1R01MH110434-01的公开数据，其中包括162名终生有精神病史的患者和178名从未患过精神病（NP）的参与者。参与者完成了测量听觉错配负性（MMN）、P300、错误相关负性和奖赏正性的任务。结果与预测相反，两组在 MMN 频率、P300 或错误相关负性的人内变异性方面没有差异；患者在 MMN 持续时间方面的变异性低于 NP 参与者。对精神分裂症患者子集的探索性分析表明，该组患者的 MMN 变异性高于 NP 组。更严重的思维障碍和激活症状与更高的个体内部 MMN 变异性相关。探索性分析表明，ERPs的个体内差异与精神分裂症和某些症状维度的关系比与广泛的精神病性障碍的关系更为密切，但这些探索性发现还需要研究来证实。

{"title":"Intraindividual Variability of Event-Related Potentials in Psychosis: A Registered Report","authors":"Amanda Holbrook , Bohyun Park , Philippe Rast , Gregory A. Light , Peter E. Clayson","doi":"10.1016/j.bpsgos.2024.100396","DOIUrl":"10.1016/j.bpsgos.2024.100396","url":null,"abstract":"<div><h3>Background</h3><div>Neurophysiological tools have yielded valuable insights into the pathophysiology and treatment of psychosis. However, studies using event-related potentials (ERPs) have primarily focused on mean scores and neglected the within-person variability of ERP scores. The neglect of within-person variability of ERPs in the search for biomarkers might have resulted in crucial differences related to psychosis being missed. In this registered report, we aimed to determine whether distinct patterns of intraindividual variability in ERP biomarkers would be observed in people with a lifetime psychosis diagnosis.</div></div><div><h3>Methods</h3><div>Publicly available data posted to the National Institute of Mental Health Data Archive for 1R01MH110434-01 was obtained for 162 patients with a lifetime history of psychosis and 178 never-psychotic (NP) participants. Participants completed tasks that measured the auditory mismatch negativity (MMN), P300, error-related negativity, and reward positivity. Multilevel location-scale models were used to determine whether patients showed greater intraindividual variability of ERP scores than NP participants.</div></div><div><h3>Results</h3><div>Contrary to predictions, the groups did not differ in within-person variability of MMN frequency, P300, or error-related negativity; patients showed less variability in MMN duration than NP participants. Exploratory analyses of a subset of patients with schizophrenia showed greater variability of MMN in this group than in the NP group. Greater severity of thought disorder and activation symptoms were associated with higher intraindividual MMN variability.</div></div><div><h3>Conclusions</h3><div>Distinct patterns of intraindividual variability in the measured ERPs were not observed for the broad group of people with lifetime psychotic disorders. Exploratory analyses suggest that intraindividual differences in ERPs are more relevant to schizophrenia and certain symptom dimensions than to psychotic disorders broadly, but research is needed to confirm these exploratory findings.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 1","pages":"Article 100396"},"PeriodicalIF":4.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Biological psychiatry global open science

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀