Biological psychiatry global open science最新文献_第7页

Clinical Criteria to Guide Antineuronal Antibody Testing for People With Early and Persistent Psychosis Attending Mental Health Services 指导参加精神卫生服务的早期和持续性精神病患者抗神经元抗体检测的临床标准

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-09-17 DOI: 10.1016/j.bpsgos.2025.100612

Gemma McKeon , Andrea Baker , Stefan Blum , David Gillis , Kerri Prain , Judith M. Greer , George Bruxner , Michael E. Benros , Sean Hatherill , Shuichi Suetani , Dan Siskind , Kate Murphy , Hitesh Joshi , Jackie Curtis , Brian O’Donoghue , Iain Macmillan , Eva Malacova , Anita Pelecanos , Patrick Waters , Belinda Lennox , James G. Scott

Background

Early detection of autoimmune psychosis (AP) mediated by antineuronal antibodies (Abs) is critical for achieving optimal clinical outcomes. However, evidence remains limited regarding who should be tested and how Ab-positive cases should be managed. In this large-scale study, we evaluated proposed clinical criteria for targeted Ab testing in psychiatric services and described the clinical course of seropositive patients.

Methods

Individuals with early psychosis (EP) or persistent psychosis (PP) were prospectively assessed with clinical criteria to determine high- or low-risk status for AP. Blood samples were collected for Ab testing using a fixed cell-based assay. Seropositive individuals were invited for detailed review, including clinical, functional, and cognitive assessments at baseline and a 12-month follow-up. Blood samples were collected from 754 individuals (EP: n = 352, PP: n = 402).

Results

Abs were present in 2.3% (17/754), including 3.4% (12/352) of patients with EP and 1.2% (5/402) of patients with PP. AP was confirmed in 2 cerebrospinal fluid (CSF)–positive high-risk individuals (total: 2/754, 0.3%; EP: 1/352, 0.3%; PP: 1/402, 0.2%). Both improved with immunotherapy. Although some low-risk patients were seropositive, none were diagnosed clinically with AP.

Conclusions

AP prevalence was low in this cohort. Targeted testing informed by clinical high-risk criteria successfully identified 2 immunotherapy-responsive AP cases. This approach appears feasible but requires further validation. People with psychosis and high-risk AP features should be considered for Ab testing in sera and CSF where indicated. Further research is required to embed targeted Ab testing into mental health services.

背景：抗神经元抗体（Abs）介导的自身免疫性精神病（AP）的检测对于获得最佳临床结果至关重要。然而，关于谁应该接受检测以及如何处理ab阳性病例的证据仍然有限。在这项大规模研究中，我们评估了精神科服务中靶向Ab检测的拟议临床标准，并描述了血清阳性患者的临床病程。方法采用临床标准对早期精神病（EP）或持续性精神病（PP）患者进行前瞻性评估，以确定AP的高风险或低风险状态。采用固定细胞法采集血样进行Ab检测。血清阳性个体被邀请进行详细的审查，包括临床、功能和认知评估基线和12个月的随访。共采集754例（EP: n = 352, PP: n = 402）血液样本。结果抗体阳性率为2.3%(17/754)，其中EP患者阳性率为3.4% (12/352)，PP患者阳性率为1.2%（5/402）。2例脑脊液（CSF）阳性高危人群中证实有AP（总数：2/754,0.3%;EP: 1/352, 0.3%; PP: 1/402, 0.2%）。两种情况在免疫治疗后都有所改善。尽管部分低危患者血清检测呈阳性，但临床均未诊断出ap。结论该队列中ap患病率较低。根据临床高危标准进行的靶向检测成功鉴定出2例免疫治疗反应性AP病例。这种方法似乎可行，但需要进一步验证。有精神病和高危AP特征的患者应考虑在血清和脑脊液中进行Ab检测。将有针对性的Ab型抗体检测纳入心理健康服务需要进一步的研究。

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引用次数: 0

Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder 功率谱斜率作为一种新的重度抑郁症脑功能指标

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-09-30 DOI: 10.1016/j.bpsgos.2025.100623

Huimin Zhou , Kaini Qiao , Jingjing Zhou , Xuequan Zhu , Zhi Yang , Gang Wang , Yanyu Wang , Zhenxiang Zang

Background

Resting-state functional magnetic resonance imaging (rs-fMRI) is a powerful tool to reveal disrupted brain activity in major depressive disorder (MDD), but most studies have focused solely on low-frequency functional fluctuations, ignoring the fact that brain activity is composed of both low-frequency and high-frequency fluctuations. Therefore, we applied a novel approach, namely the power spectral slope (PSS), which captures the characteristics of both low- and high-frequency fluctuations to evaluate brain activity in MDD.

Methods

rs-fMRI data were collected from 109 patients with MDD (27.29 ± 7.11 years, 75 women) and 78 normal control participants (26.47 ± 6.19 years, 51 women). A subset of 52 patients with MDD also underwent rs-fMRI scanning after a 12-week antidepressant treatment (escitalopram/duloxetine). Both the baseline between-group comparison and follow-up within-group comparison were performed for PSS. A 2-sample t test was used for baseline comparison with a liberal Gaussian random-field correction. The follow-up comparison was tested with paired t test.

Results

Patients with MDD showed significantly more negative PSS compared with normal control participants in the ventral striatum and temporal pole. After treatment, PSS in the ventral striatum increased significantly toward normalization, whereas the temporal pole’s slope remained unchanged. No significant correlations were found between PSS and depression severity scores.

Conclusions

This study demonstrates that MDD is characterized by more negative PSS in key affective regions. The normalization effect of ventral striatum spectral slope following antidepressant treatment suggests a region-specific response. Taken together, the findings suggest that PSS may serve as a novel brain functional marker for MDD.

背景：睡眠状态功能磁共振成像（rs-fMRI）是揭示重度抑郁症（MDD）大脑活动中断的有力工具，但大多数研究只关注低频功能波动，忽视了大脑活动由低频和高频波动组成的事实。因此，我们采用了一种新颖的方法，即功率谱斜率（PSS），它捕获了低频和高频波动的特征，以评估MDD患者的大脑活动。方法收集109例重度抑郁症患者（27.29±7.11岁，女性75例）和78例正常对照组（26.47±6.19岁，女性51例）的rs- fmri数据。52例重度抑郁症患者在接受12周抗抑郁治疗（艾司西酞普兰/度洛西汀）后也接受了rs-fMRI扫描。对PSS进行基线组间比较和随访组内比较。基线比较采用两样本t检验，并采用自由高斯随机场校正。随访比较采用配对t检验。结果重度抑郁症患者在腹侧纹状体和颞极的PSS负性表现明显高于正常对照组。治疗后，腹侧纹状体PSS显著增加，趋于正常化，而颞极斜率保持不变。PSS与抑郁严重程度评分无显著相关性。结论本研究表明，重度抑郁症在关键情感区域表现为更多的负性PSS。抗抑郁药物治疗后腹侧纹状体谱斜率的正常化效应提示区域特异性反应。综上所述，这些发现表明PSS可能作为重度抑郁症的一种新的脑功能标记物。

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引用次数: 0

Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample 与早产相关的自闭症异质性：来自西蒙斯基金会为自闭症研究提供知识样本的多祖先结果

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-09-17 DOI: 10.1016/j.bpsgos.2025.100614

Charikleia Chatzigeorgiou , Zeynep Asgel , Marina Natividad Avila , Behrang Mahjani , Vahe Khachadourian , Tade Souaiaia , Niamh Mullins , Magdalena Janecka

Background

Autism spectrum disorder (ASD) shows significant clinical variability, likely due to a combination of genetic and environmental factors. Preterm birth is a known risk factor for ASD, occurring in approximately 13% of diagnosed individuals. While genetic factors contribute to preterm birth in the general population, the relationship between genetic variation, preterm birth, and ASD heterogeneity remains unclear.

Methods

We investigated the genetic factors associated with preterm birth in 31,947 autistic individuals using data from the SPARK (Simons Foundation Powering Autism Research for Knowledge) sample. We conducted 3 ancestry-specific genome-wide association studies for African/African American, admixed American, and non-Finnish European ancestries, followed by a meta-analysis of 3308 preterm cases and 28,639 controls using METAL. Functional mapping and gene-based analyses were performed using FUMA, and genetic correlations were estimated using LDSC and Popcorn. Polygenic risk scores (PRSs) were computed with BridgePRS, using PRS of preterm birth in the general population.

Results

Our study identified ancestry-specific genetic loci associated with preterm birth in ASD cases. Although the meta-analysis results were not statistically significant, the estimated single nucleotide polymorphism heritability was 14%, indicating a meaningful contribution of common genetic variants. Across ancestry groups, preterm birth status was not significantly associated with PRSs for any psychiatric or medical conditions analyzed. However, polygenic liability to preterm birth in the general population was linked to several congenital anomalies after multiple testing adjustments.

Conclusions

These findings highlight the importance of diverse ancestries and early-life exposures in understanding ASD heterogeneity. Future research should replicate these findings in larger samples and explore rare variants associated with preterm birth to better understand the relationship between gestational duration and clinical and genetic differences in ASD.

自闭症谱系障碍（ASD）表现出显著的临床变异性，可能是遗传和环境因素共同作用的结果。早产是自闭症谱系障碍的一个已知危险因素，约13%的确诊个体发生早产。虽然遗传因素在一般人群中会导致早产，但遗传变异、早产和ASD异质性之间的关系尚不清楚。方法我们使用SPARK （Simons Foundation powered Autism Research for Knowledge）样本的数据，对31947名自闭症患者的早产相关遗传因素进行了调查。我们对非裔/非裔美国人、混血儿美国人和非芬兰血统的欧洲人进行了3项谱系特异性全基因组关联研究，随后使用METAL对3308例早产病例和28639例对照进行了荟萃分析。使用fua进行功能定位和基于基因的分析，并使用LDSC和Popcorn估计遗传相关性。使用BridgePRS计算多基因风险评分（PRSs），使用一般人群早产的PRSs。结果我们的研究确定了谱系特异性基因位点与ASD患者早产相关。虽然meta分析结果没有统计学意义，但估计的单核苷酸多态性遗传率为14%，表明常见遗传变异的贡献有意义。在整个祖先群体中，早产状况与任何精神或医学状况的PRSs分析没有显着关联。然而，在多次测试调整后，一般人群的多基因早产倾向与几种先天性异常有关。这些发现强调了不同的祖先和早期生活暴露对理解ASD异质性的重要性。未来的研究应该在更大的样本中复制这些发现，并探索与早产相关的罕见变异，以更好地了解妊娠期与ASD临床和遗传差异之间的关系。

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引用次数: 0

Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability 促肾上腺皮质激素释放因子神经元中下丘脑激素受体信号对饮酒、焦虑和扩展杏仁核神经元兴奋性的性别特异性影响

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-09-20 DOI: 10.1016/j.bpsgos.2025.100617

Yihe Ma , Haniyyah Sardar , Max E. Benabou , Angeline C. Yu , Allison R. Morningstar , R. Nicolas Fajardo , Isaac F. Kandil , Ethan T. Rogers , Anne Vassalli , Julie A. Kauer , William J. Giardino

Background

Alcohol use disorder (AUD) is characterized by compulsive alcohol consumption and negative emotional states during withdrawal, often perpetuating a cycle of addiction through arousal dysfunction. The hypocretin/orexin (HCRT) neuropeptide system is a key regulator of arousal that is implicated in these processes, particularly in its interactions with corticotropin-releasing factor (CRF) neurons within the bed nucleus of the stria terminalis (BNST).

Methods

Using CRF-specific genetic deletion of Hcrtr1 and/or Hcrtr2 receptors in mice combined with behavioral and electrophysiological approaches, we investigated the role of HCRT receptor signaling in CRF neurons in modulating alcohol intake, anxiety behaviors, and BNST excitability, with a focus on sex-specific differences.

Results

We found that deletion of Hcrtr1 significantly reduced alcohol intake, with sex-specific effects on BNST excitability and synaptic drive. CRF-specific Hcrtr2 deletion, while not affecting alcohol consumption, decreased baseline anxiety-like behaviors in males relative to females. Moreover, the double deletion of both HCRT receptors from CRF neurons led to reduced alcohol drinking in males (while tending to increase alcohol drinking in females) and dampened anxiety behaviors and BNST excitability in both sexes during protracted withdrawal.

Conclusions

These findings suggest that HCRT signaling in CRF neurons plays a critical role in the persistence of excessive alcohol consumption and the development of negative affective states, with distinct contributions from HcrtR1 and HcrtR2. The observed sex-specific differences underscore the need for tailored therapeutic approaches targeting the HCRT system in the treatment of AUD.

酒精使用障碍（AUD）的特征是强迫性饮酒和戒断期间的消极情绪状态，通常通过唤醒功能障碍使成瘾循环持续下去。下丘脑分泌素/食欲素（HCRT）神经肽系统是参与这些过程的觉醒的关键调节器，特别是在它与终纹床核（BNST）内促肾上腺皮质激素释放因子（CRF）神经元的相互作用中。方法利用小鼠CRF特异性Hcrtr1和/或Hcrtr2受体的基因缺失，结合行为和电生理方法，研究了CRF神经元中HCRT受体信号在调节酒精摄入、焦虑行为和BNST兴奋性中的作用，并重点研究了性别特异性差异。结果我们发现，Hcrtr1的缺失显著减少了酒精摄入量，并对BNST兴奋性和突触驱动产生了性别特异性影响。crf特异性Hcrtr2缺失，虽然不影响饮酒，但相对于女性，减少了男性的基线焦虑样行为。此外，CRF神经元中两种HCRT受体的双重缺失导致男性饮酒量减少（而女性饮酒量倾向于增加），并在长期戒断期间抑制两性的焦虑行为和BNST兴奋性。这些发现表明，CRF神经元中的HCRT信号在过度饮酒的持续和消极情感状态的发展中起着关键作用，HcrtR1和HcrtR2的作用不同。观察到的性别特异性差异强调了针对HCRT系统治疗AUD的量身定制治疗方法的必要性。

{"title":"Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability","authors":"Yihe Ma , Haniyyah Sardar , Max E. Benabou , Angeline C. Yu , Allison R. Morningstar , R. Nicolas Fajardo , Isaac F. Kandil , Ethan T. Rogers , Anne Vassalli , Julie A. Kauer , William J. Giardino","doi":"10.1016/j.bpsgos.2025.100617","DOIUrl":"10.1016/j.bpsgos.2025.100617","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use disorder (AUD) is characterized by compulsive alcohol consumption and negative emotional states during withdrawal, often perpetuating a cycle of addiction through arousal dysfunction. The hypocretin/orexin (HCRT) neuropeptide system is a key regulator of arousal that is implicated in these processes, particularly in its interactions with corticotropin-releasing factor (CRF) neurons within the bed nucleus of the stria terminalis (BNST).</div></div><div><h3>Methods</h3><div>Using CRF-specific genetic deletion of <em>Hcrt</em><em>r</em><em>1</em> and/or <em>Hcrt</em><em>r</em><em>2</em> receptors in mice combined with behavioral and electrophysiological approaches, we investigated the role of HCRT receptor signaling in CRF neurons in modulating alcohol intake, anxiety behaviors, and BNST excitability, with a focus on sex-specific differences.</div></div><div><h3>Results</h3><div>We found that deletion of <em>Hcrt</em><em>r</em><em>1</em> significantly reduced alcohol intake, with sex-specific effects on BNST excitability and synaptic drive. CRF-specific <em>Hcrt</em><em>r</em><em>2</em> deletion, while not affecting alcohol consumption, decreased baseline anxiety-like behaviors in males relative to females. Moreover, the double deletion of both HCRT receptors from CRF neurons led to reduced alcohol drinking in males (while tending to increase alcohol drinking in females) and dampened anxiety behaviors and BNST excitability in both sexes during protracted withdrawal.</div></div><div><h3>Conclusions</h3><div>These findings suggest that HCRT signaling in CRF neurons plays a critical role in the persistence of excessive alcohol consumption and the development of negative affective states, with distinct contributions from HcrtR1 and HcrtR2. The observed sex-specific differences underscore the need for tailored therapeutic approaches targeting the HCRT system in the treatment of AUD.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 1","pages":"Article 100617"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture 应激诱导的引导线索受体DCC失调改变皮质边缘电路结构

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-10-08 DOI: 10.1016/j.bpsgos.2025.100629

Ashraf Mahmud , Giovanni Hernandez , Fatme Abboud , Cecilia Flores

Background

Elevated expression of the guidance cue receptor gene DCC in the adult prefrontal cortex (PFC) is a hallmark of major depressive disorder. DCC receptors regulate neuronal connectivity and plasticity in adulthood. In male mice, Dcc knockout in the PFC promotes resilience to behavioral dysregulation following chronic social defeat stress (CSDS), whereas Dcc upregulation increases susceptibility. However, the underlying mechanisms remain to be elucidated.

Methods

We combined CSDS, behavioral tests (i.e., social interaction, nestlet shredding, and dark-light tests), retrograde neuronal tracing, and quantitative neuroanatomical analysis in adult male mice (N = 90) to investigate whether DCC receptors contribute to stress susceptibility/resilience by remodeling dendritic spine architecture of selective PFC neuronal networks.

Results

CSDS reduced both mature and newly formed spines on the apical, but not basal, dendrites of PFC pyramidal neurons. This effect was prevented by downregulating DCC receptors in these neurons, a manipulation that also prevented depression-like behaviors, suggesting a mechanistic link. DCC-expressing neurons in the PFC predominantly projected to the nucleus accumbens, and social defeat stress induced dendritic spine loss specifically in projections from the infralimbic PFC. Notably, knockout of DCC receptors in infralimbic PFC neurons projecting to the nucleus accumbens shell protected against stress-induced social avoidance.

Conclusions

DCC receptors may influence susceptibility or resilience to social stress–induced depression-like behaviors by altering the apical dendritic architecture of PFC pyramidal neurons, particularly those projecting to the nucleus accumbens shell. This mechanism may be at play in the neurobiology of depression, pointing to DCC receptors as promising therapeutic targets.

成人前额叶皮质（PFC）中引导线索受体基因DCC的表达升高是重度抑郁症的一个标志。DCC受体调节成年期神经元的连通性和可塑性。在雄性小鼠中，PFC中的Dcc敲除促进了对慢性社会失败应激（CSDS）后行为失调的恢复能力，而Dcc上调则增加了易感性。然而，潜在的机制仍有待阐明。方法结合CSDS、行为实验（社交、破巢、暗光实验）、逆行神经元示踪和定量神经解剖学分析，探讨DCC受体是否通过重塑选择性PFC神经元网络的树突棘结构参与应激敏感性/恢复能力。结果scsds减少了PFC锥体神经元顶端树突的成熟棘和新生棘，但没有减少基部树突的新生棘。这种效果可以通过下调这些神经元中的DCC受体来阻止，这种操作也可以阻止类似抑郁的行为，这表明了一种机制联系。PFC中表达DCC的神经元主要投射到伏隔核，社交失败应激导致树突棘的损失，特别是在边缘下PFC的投射中。值得注意的是，敲除边缘下PFC神经元中投射到伏隔核外壳的DCC受体可以防止应激诱导的社交回避。结论sdcc受体可能通过改变PFC锥体神经元的顶端树突结构，特别是突起到伏隔核壳的树突结构，影响对社会压力诱导的抑郁样行为的易感性或恢复性。这种机制可能在抑郁症的神经生物学中起作用，指出DCC受体是有希望的治疗靶点。

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引用次数: 0

Rethinking Trichotillomania 反思拔毛发癖

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-11-10 DOI: 10.1016/j.bpsgos.2025.100625

Jon E. Grant

引用次数: 0

Engagement of the Paraventricular Nucleus of the Thalamus During Withdrawal-Related Learning: Implications for Alcohol Use Disorder 戒断相关学习期间丘脑室旁核的参与：对酒精使用障碍的影响

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI: 10.1016/j.bpsgos.2025.100621

Laureta Gashi , Sophia Khom

引用次数: 0

Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder 电生理生物标志物反映目标参与和反应使用深部脑刺激强迫症

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2026-01-01 Epub Date: 2025-09-09 DOI: 10.1016/j.bpsgos.2025.100609

Tine Van Bogaert , Martijn Figee , Brian H. Kopell , Andrew Smith , Jungho Cha , Ha Neul Song , Davide Momi , Zarghona Imtiaz , Sanjana Murthy , Sonia Olson , Elisa Xu , Helen Mayberg , Myles Mc Laughlin , Ki Sueng Choi , Allison C. Waters

Background

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an effective treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). However, optimizing lead placement and stimulation parameters remains a challenge. DBS evoked potentials (EPs) recorded with electroencephalography (EEG) during surgical lead placement could serve as intraoperative biomarkers for target engagement and clinical efficacy.

Methods

We obtained intraoperative EEG recordings on the forehead from 10 patients (2 nonresponders) undergoing ALIC DBS surgery for OCD. Monopolar stimulation at 2 Hz was delivered through all electrode contacts, and EEG EPs were analyzed in relation to stimulation contact, white matter connectivity to the prefrontal cortical regions of interest (assessed via probabilistic tractography), and reduction in symptom severity (assessed with the Yale-Brown Obsessive Compulsive Scale).

Results

We observed consistent DBS EPs with 3 oscillatory peaks (∼35, ∼75, and ∼120 ms) across all patients. EP amplitude varied across contacts, with the largest responses occurring when the location of stimulation overlapped with the preoperatively defined tractographic target. Higher EP amplitudes recorded on the forehead correlated with greater white matter connectivity to the ventromedial prefrontal cortex/orbitofrontal cortex and ventrolateral prefrontal cortex. Treatment nonresponders exhibited less consistent EP waveforms across lead contacts.

Conclusions

These findings suggest that intraoperative EPs provide valuable insights into ALIC DBS target engagement. EP characteristics may serve as biomarkers to refine DBS targeting and predict clinical response, offering a potential tool for optimizing DBS therapy for OCD.

脑深部电刺激（DBS）的前肢内囊（ALIC）是一种有效的治疗严重的，治疗难治性强迫症（OCD）。然而，优化导联剂的放置和增产参数仍然是一个挑战。脑电图（EEG）记录的脑起搏器诱发电位（EPs）可作为术中靶接触和临床疗效的生物标志物。方法对10例接受ALIC DBS手术治疗强迫症的患者（2例无反应）进行术中脑电图记录。通过所有电极接触传递2hz的单极刺激，并分析脑电图EPs与刺激接触、白质与感兴趣的前额皮质区域的连通性（通过概率神经束造影评估）以及症状严重程度的降低（用耶鲁-布朗强迫症量表评估）的关系。我们在所有患者中观察到一致的DBS EPs有3个振荡峰（~ 35、~ 75和~ 120 ms）。EP振幅在接触过程中变化，当刺激位置与术前确定的牵道图目标重叠时，发生最大的反应。前额记录的高电位振幅与腹内侧前额叶皮层/眼窝前额叶皮层和腹外侧前额叶皮层之间的白质连接性增强相关。治疗无应答者在铅触点处表现出不太一致的电位波形。结论术中EPs为ALIC DBS靶标结合提供了有价值的见解。EP特征可以作为生物标志物来完善DBS靶向和预测临床反应，为优化DBS治疗强迫症提供了一个潜在的工具。

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引用次数: 0

Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis 首发精神病的功能耦合和纵向预后预测

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-08-11 DOI: 10.1016/j.bpsgos.2025.100589

Isaac Z. Pope , Sidhant Chopra , Alexander Holmes , Shona M. Francey , Brian O’Donoghue , Vanessa L. Cropley , Barnaby Nelson , Hok Pan Yuen , Kelly Allott , Mario Alvarez-Jimenez , Susy Harrigan , Christos Pantelis , Andrew Thompson , Stephen J. Wood , Patrick D. McGorry , Alex Fornito

Background

Clinical outcomes following the first episode of psychosis (FEP) are highly heterogeneous across patients. The identification of prognostic biomarkers would greatly facilitate personalized treatments. Patients with psychosis often display brainwide disruptions of interregional functional coupling (FC), with some being linked to symptom severity and remission. Thus, FC may have prognostic potential for people experiencing psychosis.

Methods

Fifty-five antipsychotic-naïve patients with FEP (51% female, ages 15–25 years) were randomized to receive either antipsychotic or placebo tablets for 6 months alongside psychosocial interventions. Functional magnetic resonance imaging was conducted at baseline and after 3 months to evaluate whether baseline FC or 3-month change in FC could predict 6- and 12-month changes in symptoms and functioning, quantified using the Brief Psychiatric Rating Scale and the Social and Occupational Functioning Assessment Scale, respectively. We considered 3 different cross-validated prediction algorithms: 1) connectome-based predictive modeling, 2) kernel ridge regression, and 3) multilayer meta-matching. Each prediction model comprised 35 to 49 individuals.

Results

All models showed poor performance in predicting patients’ 6- and 12-month changes in symptoms and functioning (all r_mean < 0.3), and no model achieved significance via permutation testing (all p > .05).

Conclusions

Our findings suggest that brainwide measures of FC may not be suitable for predicting extended clinical outcomes over a 6- to 12-month period in patients with FEP.

背景：首次精神病发作（FEP）后的临床结果在不同患者之间存在高度异质性。预后生物标志物的识别将极大地促进个性化治疗。精神病患者经常表现出全脑区域间功能耦合（FC）的中断，其中一些与症状的严重程度和缓解有关。因此，FC可能对患有精神病的人具有预后潜力。方法55例antipsychotic-naïve FEP患者（51%为女性，年龄15-25岁）随机接受抗精神病药或安慰剂片6个月，并进行心理社会干预。在基线和3个月后进行功能磁共振成像，以评估基线FC或3个月FC变化是否可以预测6个月和12个月的症状和功能变化，分别使用简短精神病学评定量表和社会与职业功能评估量表进行量化。我们考虑了3种不同的交叉验证预测算法：1)基于连接体的预测建模，2)核脊回归和3)多层元匹配。每个预测模型由35到49个人组成。结果所有模型在预测患者6个月和12个月的症状和功能变化方面均表现不佳（均均值<； 0.3），经排列检验均无模型达到显著性（均p >； 0.05）。研究结果表明，全脑FC测量可能不适合预测FEP患者6至12个月的长期临床结果。

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引用次数: 0

Trichotillomania and Risk of Alcohol- and Drug-Related Problems 拔毛癖与酒精和药物相关问题的风险

IF 3.7 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2025-11-01 Epub Date: 2025-09-02 DOI: 10.1016/j.bpsgos.2025.100605

Luis C. Farhat , Kayoko Isomura , Ralf Kuja-Halkola , Isabell Brikell , Zheng Chang , Brian M. D’Onofrio , Henrik Larsson , Paul Lichtenstein , Lorena Fernández de la Cruz , Anna Sidorchuk , David Mataix-Cols

Background

Trichotillomania is an understudied psychiatric disorder characterized by repeated hair-pulling resulting in hair loss. Little is known about the risk of problematic substance use in this patient group. In this nationwide matched cohort study, we investigated the association between trichotillomania and substance-related problems.

Methods

We linked various nationwide administrative and clinical registers in Sweden. Among 12,015,664 individuals living in the country from January 1, 1997, to December 31, 2020, we identified 1136 individuals with an ICD-10 diagnosis of trichotillomania at age ≥10 years (86.4% female, median age at first diagnosis 23.8 years [interquartile range 13.3–34.9 years]) and matched them with 11,360 unaffected individuals. The outcome was broadly defined as substance-related problems (alcohol- and drug-related disorders, suspected criminal offenses, and deaths). Stratified Cox proportional hazards regression was used to determine hazard ratios (HRs) for the association between trichotillomania and any substance-related problems.

Results

Over a mean follow-up period of 6 years, substance-related problems were recorded for 137 (12.1%) individuals with trichotillomania and 399 (3.5%) matched individuals (crude incidence rates per 1000 person-years of 21.6 and 5.6, respectively). After controlling for sociodemographic covariates and parental substance-related problems, trichotillomania was associated with an increased relative risk of substance-related problems (HR, 3.12; 95% CI, 2.53–3.85). Adjusting also for comorbid psychiatric history did not meaningfully change the findings.

Conclusions

Individuals with trichotillomania had a 3-fold increased risk of substance-related problems compared with unaffected individuals. Future research should examine the mechanisms underlying this association and inform the clinical management of the dual diagnoses.

拔毛癖是一种未被充分研究的精神疾病，其特征是反复拔头发导致脱发。在这个病人群体中，人们对问题药物使用的风险知之甚少。在这项全国性的匹配队列研究中，我们调查了拔毛癖和物质相关问题之间的关系。方法我们将瑞典全国不同的行政和临床登记处联系起来。在1997年1月1日至2020年12月31日居住在该国的12015664名个体中，我们确定了1136名年龄≥10岁的ICD-10诊断为拔毛癖的个体（86.4%为女性，首次诊断时的中位年龄为23.8岁[四分位数间距为13.3-34.9岁]），并将其与11360名未患病个体进行匹配。结果被广泛地定义为与物质有关的问题（与酒精和毒品有关的失调、涉嫌犯罪和死亡）。使用分层Cox比例风险回归来确定拔毛癖与任何物质相关问题之间关联的风险比（hr）。结果在平均6年的随访期间，有137例（12.1%）拔毛癖患者和399例（3.5%）匹配患者（粗发病率分别为每1000人年21.6例和5.6例）记录了与物质相关的问题。在控制了社会人口学协变量和父母物质相关问题后，拔毛癖与物质相关问题的相对风险增加相关（HR, 3.12; 95% CI, 2.53-3.85）。同时调整共病精神病史并没有改变研究结果。结论：与未受影响的个体相比，拔毛癖患者出现物质相关问题的风险增加了3倍。未来的研究应该检查这种关联的机制，并告知双重诊断的临床管理。

{"title":"Trichotillomania and Risk of Alcohol- and Drug-Related Problems","authors":"Luis C. Farhat , Kayoko Isomura , Ralf Kuja-Halkola , Isabell Brikell , Zheng Chang , Brian M. D’Onofrio , Henrik Larsson , Paul Lichtenstein , Lorena Fernández de la Cruz , Anna Sidorchuk , David Mataix-Cols","doi":"10.1016/j.bpsgos.2025.100605","DOIUrl":"10.1016/j.bpsgos.2025.100605","url":null,"abstract":"<div><h3>Background</h3><div>Trichotillomania is an understudied psychiatric disorder characterized by repeated hair-pulling resulting in hair loss. Little is known about the risk of problematic substance use in this patient group. In this nationwide matched cohort study, we investigated the association between trichotillomania and substance-related problems.</div></div><div><h3>Methods</h3><div>We linked various nationwide administrative and clinical registers in Sweden. Among 12,015,664 individuals living in the country from January 1, 1997, to December 31, 2020, we identified 1136 individuals with an ICD-10 diagnosis of trichotillomania at age ≥10 years (86.4% female, median age at first diagnosis 23.8 years [interquartile range 13.3–34.9 years]) and matched them with 11,360 unaffected individuals. The outcome was broadly defined as substance-related problems (alcohol- and drug-related disorders, suspected criminal offenses, and deaths). Stratified Cox proportional hazards regression was used to determine hazard ratios (HRs) for the association between trichotillomania and any substance-related problems.</div></div><div><h3>Results</h3><div>Over a mean follow-up period of 6 years, substance-related problems were recorded for 137 (12.1%) individuals with trichotillomania and 399 (3.5%) matched individuals (crude incidence rates per 1000 person-years of 21.6 and 5.6, respectively). After controlling for sociodemographic covariates and parental substance-related problems, trichotillomania was associated with an increased relative risk of substance-related problems (HR, 3.12; 95% CI, 2.53–3.85). Adjusting also for comorbid psychiatric history did not meaningfully change the findings.</div></div><div><h3>Conclusions</h3><div>Individuals with trichotillomania had a 3-fold increased risk of substance-related problems compared with unaffected individuals. Future research should examine the mechanisms underlying this association and inform the clinical management of the dual diagnoses.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"5 6","pages":"Article 100605"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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