Biological psychiatry global open science最新文献

英文中文

Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function 研究精神疾病与执行功能之间的共同遗传结构

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-10 DOI: 10.1016/j.bpsgos.2024.100392

Sijie Zhang , Linlin Zhao , Aijun Liao , David Li , Hong Li , Lijun Ouyang , Xiaogang Chen , Zongchang Li

Background

Evidence for widespread comorbidity of executive dysfunctions with psychiatric disorders suggests common mechanisms underlying their pathophysiology. However, the shared genetic architectures between psychiatric disorders and executive function (EF) remain poorly understood.

Methods

Leveraging large genome-wide association study datasets of European ancestry on bipolar disorder (N = 353,899), major depressive disorder (N = 674,452), and schizophrenia (N = 130,644) from the Psychiatric Genomics Consortium and iPSYCH and a common factor of EF (N = 427,037) from UK Biobank, we systematically investigated the shared genomic architectures between psychiatric disorders and EF with a set of statistical genetic, functional genomic, and gene-level analyses.

Results

Our study demonstrated substantial genetic overlaps and significant genetic correlations between psychiatric disorders and EF. EF showed an estimated 95.9%, 98.1%, and 99.2% of phenotype-influencing variants, as well as 50, 23, and 130 genomic loci shared with bipolar disorder, major depressive disorder, and schizophrenia, respectively. Single nucleotide polymorphism heritability enrichment suggests that the genetic architecture of psychiatric disorders and EF involves the brain’s frontal cortex and prefrontal glutamatergic neurons 1 and 2. Functional genomic analysis of shared variants identified 12 functional regulatory variants that regulate gene expression by affecting the binding affinities of 5 transcription factors. In addition, functional characterization analyses of shared genes revealed potential common biological mechanisms related to synaptic processes and fetal brain development.

Conclusions

Our findings provide evidence for extensive shared genetic architectures between psychiatric disorders and EF and have valuable implications for future mechanistic investigations and drug development efforts.

背景执行功能障碍与精神障碍广泛共存的证据表明，它们的病理生理学有着共同的机制。然而，人们对精神疾病与执行功能（EF）之间的共同遗传结构仍然知之甚少。方法利用精神病基因组学联合会和 iPSYCH 的大型欧洲血统双相情感障碍（N = 353,899 ）、重度抑郁障碍（N = 674,452 ）和精神分裂症（N = 130,644 ）全基因组关联研究数据集，以及英国生物库的 EF 共同因子（N = 427、037），我们通过一系列遗传统计、功能基因组和基因水平分析，系统地研究了精神疾病和 EF 之间的共享基因组结构。结果我们的研究表明，精神疾病与心房颤动之间存在大量的遗传重叠和显著的遗传相关性。估计 95.9%、98.1% 和 99.2% 的表型影响变异以及 50、23 和 130 个基因组位点分别与双相情感障碍、重度抑郁障碍和精神分裂症共享。单核苷酸多态性遗传富集表明，精神障碍和EF的遗传结构涉及大脑额叶皮层和前额叶谷氨酸能神经元1和2。对共有变异的功能基因组分析发现了 12 个功能调控变异，它们通过影响 5 个转录因子的结合亲和力来调控基因表达。此外，共享基因的功能特征分析揭示了与突触过程和胎儿大脑发育有关的潜在共同生物机制。结论我们的研究结果为精神疾病和 EF 之间广泛的共享遗传结构提供了证据，对未来的机理研究和药物开发工作具有重要意义。

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引用次数: 0

Size and Topography of the Brain’s Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder 精神错乱体验、精神分裂症和躁郁症患者大脑功能网络的规模和拓扑图

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-07 DOI: 10.1016/j.bpsgos.2024.100386

Daniel Mamah , Shing Shiun Chen , Evan Gordon , Sridhar Kandala , Deanna M. Barch , Michael P. Harms

Background

Existing functional connectivity studies of psychosis use population-averaged functional network maps, despite highly variable topographies of these networks across the brain surface. We aimed to define the functional network areas and topographies in the general population and the changes associated with psychotic experiences (PEs) and disorders.

Methods

Maps of 8 functional networks were generated using an individual-specific template-matching procedure for each participant from the Human Connectome Project Young Adult cohort (n = 1003) and from a matched case cohort (schizophrenia [SCZ], n = 27; bipolar disorder, n = 35) scanned identically with the same Connectom scanner. In the Human Connectome Project Young Adult cohort, PEs were estimated based on scores from the Achenbach Self-Report Scale. The relationship of symptoms to the probability of network representation at each cortical vertex was assessed using logistic regression.

Results

In Human Connectome Project Young Adult participants, PE severity on the Achenbach thought problems scale was predicted by increased language network (LAN) and dorsal attention network (DAN) areas and decreased cingulo-opercular network area (r < 0.12). Significant effects were found in SCZ, with a larger DAN and LAN and a smaller frontoparietal network. Network pattern analysis in SCZ showed an increased probability of LAN in the posterior region of the left superior temporal gyrus and of the visual network in the left insula. Regression analyses in SCZ found that mood dysregulation was related to increased DAN surface area.

Conclusions

Those with PEs and SCZ showed abnormal functional network cortical topographies, particularly involving DAN and LAN. Network findings may predict psychosis progression and guide earlier intervention.

背景现有的精神病功能连接研究使用的是人群平均功能网络图，尽管这些网络在整个大脑表面的拓扑结构变化很大。我们的目的是确定普通人群的功能网络区域和拓扑图，以及与精神病性体验（PEs）和障碍相关的变化。方法使用特定于个体的模板匹配程序，为人类连接组项目青年成人队列（n = 1003）和匹配病例队列（精神分裂症 [SCZ]，n = 27；双相情感障碍，n = 35）中的每位参与者生成 8 个功能网络图。在人类连接组计划年轻成人队列中，PE 是根据 Achenbach 自我报告量表的得分估算的。结果在人类连接组计划的年轻成人参与者中，语言网络（LAN）和背侧注意力网络（DAN）区域的增加以及丘脑-小脑网络区域的减少（r <0.12）可预测Achenbach思想问题量表中PE的严重程度。在 SCZ 中发现了显著的影响，DAN 和 LAN 变大，额顶网络变小。SCZ 的网络模式分析显示，左侧颞上回后部区域和左侧岛叶视觉网络出现 LAN 的概率增加。SCZ患者的回归分析发现，情绪失调与DAN表面积的增加有关。网络发现可预测精神病的发展并指导早期干预。

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引用次数: 0

Deep Screening for X Chromosome Parent-of-Origin Effects on Neurobehavioral and Neuroanatomical Phenotypes in 47,XXY Klinefelter Syndrome 深度筛查 X 染色体原生父母对 47,XXY 克莱恩费尔特综合征神经行为和神经解剖表型的影响

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-04 DOI: 10.1016/j.bpsgos.2024.100391

Isabella G. Larsen , Rachel Gore Moses , Bryce A. Seifert , Siyuan Liu , Samuel Li , Andrew J. Oler , Elizabeth Levitis , Lukas Schaffer , Rylee Duncan , Colleen Jodarski , Michael Kamen , Jia Yan , François M. Lalonde , Rajarshi Ghosh , Erin Torres , Liv S. Clasen , Jonathan Blumenthal , Morgan Similuk , Armin Raznahan , Magdalena A. Walkiewicz

Background

X chromosome parent of origin (POX) has been proposed as a source of phenotypic variation within sex chromosome aneuploidies such as Klinefelter syndrome (XXY/KS) and between XX and XY individuals. However, previous studies have yielded conflicting results regarding the presence and nature of POX effects, which we sought to clarify in an expanded sample with deeper neurobehavioral phenotyping.

Methods

A cohort of 58 individuals with XXY/KS underwent duo or trio genome sequencing with parents (n = 151), measurement of 66 neurobehavioral phenotypes by standardized research assessments, and measurement of over 1000 anatomical phenotypes by structural magnetic resonance imaging. We developed a novel algorithm, the uniparental disomy visualization for variant call format files, to determine proband POX and then systematically tested for POX associations with all neurobehavioral and neuroanatomical outcomes.

Results

The uniparental disomy visualization for variant call format files algorithm showed maternal POX in 35 of 58 cases (60.3%). There were no statistically significant POX effects on any of the 66 subscale measures of cognition, psychopathology, or behavior. Neuroimaging analysis identified 2 regions in the right hemisphere with significantly higher surface area (mean effect size = 1.20) among individuals with paternal versus maternal POX (q = .021).

Conclusions

Using deeper phenotyping in an expanded sample, we did not find evidence for substantial POX effects on neurobehavioral variability, except for localized unilateral modulations of surface area in the absence of co-occurring behavioral associations. These findings help to clarify previous inconsistencies in POX research and direct attention toward other sources of clinical variability in sex chromosome aneuploidies.

背景X染色体原父（POX）被认为是性染色体非整倍体（如Klinefelter综合征（XXY/KS））内部以及XX和XY个体之间表型变异的来源。方法：58 名 XXY/KS 患者与父母（n = 151）一起接受了双基因组或三基因组测序，通过标准化研究评估测量了 66 种神经行为表型，并通过结构磁共振成像测量了 1000 多种解剖表型。我们开发了一种新型算法--变异调用格式文件的单亲断裂可视化算法，用于确定原告的POX，然后系统检测了POX与所有神经行为和神经解剖结果的关联。在认知、精神病理学或行为的 66 个分量表测量中，POX 对任何一项都没有统计学意义上的影响。结论通过对扩大样本进行更深入的表型分析，我们没有发现POX对神经行为变异性有实质性影响的证据，除了在没有并发行为关联的情况下，局部单侧表面积的改变。这些发现有助于澄清以前在 POX 研究中存在的不一致之处，并引导人们关注性染色体非整倍体临床变异的其他来源。

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引用次数: 0

Mindfulness Training in High-Demand Cohorts Alters Resting-State Electroencephalography: An Exploratory Investigation of Individual Alpha Frequency, Aperiodic 1/f Activity, and Microstates 高需求群体中的正念训练会改变静息态脑电图：对个体阿尔法频率、非周期性 1/f 活动和微观状态的探索性研究

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-02 DOI: 10.1016/j.bpsgos.2024.100383

Chloe A. Dziego , Anthony P. Zanesco , Ina Bornkessel-Schlesewsky , Matthias Schlesewsky , Elizabeth A. Stanley , Amishi P. Jha

Background

Mindfulness training (MT) programs have demonstrated utility as cognitive training tools, but there is little consensus on the neurophysiological processes that may underlie its benefits. It has been posited that intrinsic brain activity recorded at rest reflects the functional connectivity of large-scale brain networks and may provide insight into neuroplastic changes that support MT. In the current study, we indexed changes in several resting-state electroencephalography (EEG) parameters to investigate the neurophysiological underpinnings of MT.

Methods

Resting-state EEG data were collected from active-duty U.S. military personnel (N = 80) at 2 testing sessions: before (time [T] 1) and after (T2) engaging in an 8-week MT or active comparison intervention (positivity training). We examined longitudinal and/or groupwise differences in several EEG parameters through parameterization of power spectra (individual alpha frequency and 1/f activity) and microstate analysis.

Results

While no significant group × time differences were observed in individual alpha frequency, significant group × time effects were observed in several EEG parameters from T1 to T2. Compared with MT, positivity training was associated with a steepening of the 1/f slope and higher 1/f intercepts together with decreased duration and increased global field power of microstates.

Conclusions

Taken together, these results suggest that the effects of interventions may be differentiated in resting-state brain activity in a sample of military personnel. Such findings provide insight into the neural underpinnings of MT-related brain changes, but more research is required to elucidate how these may relate to task-related neural and performance changes with MT and whether results generalize to other mindfulness interventions in alternative cohorts and contexts.

背景正念训练（Mindfulness Training，MT）项目已被证明是一种有效的认知训练工具，但对于其益处所依赖的神经生理过程却鲜有共识。有人认为，静息状态下记录到的内在大脑活动反映了大规模大脑网络的功能连接性，可能有助于了解支持正念训练的神经可塑性变化。在当前的研究中，我们对静息状态脑电图（EEG）的几个参数的变化进行了索引，以研究 MT 的神经生理学基础。方法：我们收集了现役美国军人（N = 80）在两次测试中的静息状态脑电图数据：在参加为期 8 周的 MT 或积极比较干预（积极性训练）之前（时间 [T] 1）和之后（T2）。我们通过功率谱参数化（单个阿尔法频率和 1/f 活动）和微状态分析研究了几个脑电图参数的纵向和/或组间差异。结果虽然在单个阿尔法频率上没有观察到显著的组间 × 时间差异，但在 T1 到 T2 的几个脑电图参数上观察到显著的组间 × 时间效应。与 MT 相比，积极性训练与 1/f 斜率变陡、1/f 截距增大以及微态持续时间缩短和全场功率增大有关。这些发现为了解与 MT 相关的大脑变化的神经基础提供了洞察力，但还需要更多的研究来阐明这些变化与 MT 任务相关的神经和表现变化之间的关系，以及这些结果是否能推广到其他队列和环境中的其他正念干预。

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引用次数: 0

Unraveling Autism: Using Brain Organoids to Investigate Sex Differences in Brain Development 揭开自闭症的神秘面纱利用脑有机体研究大脑发育的性别差异

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100360

Max Mitchell , Aleksandra Spasova , Yasir Ahmed Syed

引用次数: 0

The Role of Awe and Other Psychological Factors in Ketamine’s Mechanism of Antidepressant Action 敬畏及其他心理因素在氯胺酮抗抑郁作用机制中的作用

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100353

Mina Ansari, Gerard Sanacora

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Editorial Board Page 编辑委员会页面

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/S2667-1743(24)00091-0

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Targeting Deep Structures to Noninvasively Modulate Fear and Anxiety 瞄准深层结构，以无创方式调节恐惧和焦虑

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100363

Odile A. van den Heuvel

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Subscribers Page 订阅者页面

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/S2667-1743(24)00092-2

引用次数: 0

Neurobiological Underpinnings of Adolescent Susceptibility to Stress 青少年易受压力影响的神经生物学基础

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100364

Patricio O’Donnell

引用次数: 0

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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Biological psychiatry global open science

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