Biological psychiatry global open science最新文献

英文中文

Targeting Deep Structures to Noninvasively Modulate Fear and Anxiety 瞄准深层结构，以无创方式调节恐惧和焦虑

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100363

Odile A. van den Heuvel

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/S2667-1743(24)00092-2

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Neurobiological Underpinnings of Adolescent Susceptibility to Stress 青少年易受压力影响的神经生物学基础

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100364

Patricio O’Donnell

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Negative Schizotypy: Now That We Know What It Is, Should We Do Something About It? 消极分裂型：现在我们知道了它是什么，我们是否应该做些什么？

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/j.bpsgos.2024.100354

Philip D. Harvey

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Biological psychiatry global open science

Pub Date : 2024-09-01 DOI: 10.1016/S2667-1743(24)00094-6

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Borderline Personality Disorder Symptoms and Stressful Life Events: An Evaluation of Gene-Environment Interplay 边缘型人格障碍症状与生活压力事件：基因与环境相互作用的评估

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Biological psychiatry global open science

Pub Date : 2024-08-30 DOI: 10.1016/j.bpsgos.2024.100390

Vilde Sofie Arneberg , Vilde Sundsvold , Ludvig Daae Bjørndal , Eivind Ystrom

Background

Borderline personality disorder (BPD) is associated with high rates of stressful life events (SLEs). It is unclear whether people who experience SLEs have more BPD symptoms after accounting for the effects of familial risk factors. Our aims in the current study were to 1) create a predictive model of BPD using stressors across age and contexts and 2) examine whether SLEs resulted in higher levels of BPD symptoms beyond the effects of genetic and environmental risk factors.

Methods

The sample comprised 2801 twins from the Norwegian Institute of Public Health Twin Panel. Poisson regression was used to explore which SLEs predicted BPD symptoms. Elastic net penalized regression was conducted to develop a predictive model for SLEs and BPD symptoms. Co-twin control analyses were performed to differentiate between environmental and genetic factors.

Results

SLEs experienced during childhood and adulthood were associated with BPD symptoms. A weighted polyevent risk score explained 22% of the total variation in symptoms. Shared environmental and heritable factors explained 31% and 47% of individual differences in BPD symptomatology, respectively. Measured SLEs explained 42% of the shared environmental risk for BPD. The predictive risk of SLEs for BPD was reduced when shared environmental and genetic factors were accounted for. However, SLEs increased risk of BPD symptoms beyond the effects of shared genetic and environmental factors.

Conclusions

BPD symptomatology following SLEs cannot fully be explained by genetic and shared environmental factors. The SLE-BPD symptoms associations were primarily due to selection by family environments. It is important to identify familial factors that lead to both SLEs and BPD symptoms. SLEs remained associated with BPD symptoms beyond genetic and environmental confounding.

背景边缘型人格障碍（BPD）与高比率的生活压力事件（SLEs）有关。目前还不清楚在考虑了家族风险因素的影响后，经历过 SLE 的人是否会有更多的 BPD 症状。本研究的目的是：1）利用跨年龄和跨环境的压力源建立一个BPD预测模型；2）研究SLE是否会导致遗传和环境风险因素影响之外的更高水平的BPD症状。采用泊松回归法探讨哪些SLE可预测BPD症状。弹性净惩罚回归用于建立SLE和BPD症状的预测模型。为了区分环境因素和遗传因素，还进行了同卵双生子对照分析。加权多事件风险评分解释了症状总变化的 22%。共同的环境因素和遗传因素分别解释了 31% 和 47% 的 BPD 症状个体差异。测得的 SLE 可解释 42% 的 BPD 共同环境风险。在考虑了共同环境因素和遗传因素后，SLEs 对 BPD 的预测风险降低了。然而，SLE 增加的 BPD 症状风险超出了共同遗传和环境因素的影响。系统性红斑狼疮与 BPD 症状的关联主要是由于家庭环境的选择。确定导致系统性红斑狼疮和 BPD 症状的家族因素非常重要。系统性红斑狼疮与 BPD 症状的相关性仍然超出了遗传和环境因素的影响。

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A Systematic Review and Meta-Analysis of Anxiety- and Depressive-Like Behaviors in Rodent Models of Neuropathic Pain 神经性疼痛啮齿动物模型中焦虑和抑郁样行为的系统回顾和元分析

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-08-26 DOI: 10.1016/j.bpsgos.2024.100388

Tomás de la Rosa , Meritxell Llorca-Torralba , Adrián Martínez-Cortés , Cristina Romero-López-Alberca , Esther Berrocoso

Background

Epidemiological studies have frequently shown the concurrence of chronic pain with symptoms of anxiety and depression, particularly in women. Animal models are useful to understand the complex mechanisms underlying comorbidities, but the wide range of methods employed and the wealth of evidence sometimes impedes effective translation and reproducibility. In this systematic review and meta-analysis, we aimed to synthesize the evidence regarding the influence of variables such as sex and species on anxiety- and depressive-like behaviors in rodent models of neuropathic pain.

Methods

Following PROSPERO registration, we searched EMBASE, Scopus, and the Web of Science from their inception to November 24, 2023, identifying 126 studies that met the inclusion criteria. The Hedges’ g value for each experiment and study was calculated, and further subgroup and meta-regression analyses were performed.

Results

Neuropathic pain significantly reduced the time that rats and mice spent in the open arms of the elevated plus and zero mazes (g = −1.14), time spent in the center of the open field (g = −1.12), sucrose consumption in the sucrose preference test (g = −1.43), and grooming time in the splash test (g = −1.37) while increasing latency to feed in the novelty-suppressed feeding test (g = 1.59) and immobility in the forced swimming (g = 1.85) and tail suspension (g = 1.91) tests. Sex differences were observed, with weaker effects in female than in male rodents for several behavioral paradigms, and funnel plots identified positive publication bias in the literature.

Conclusions

This meta-analysis emphasizes the effect of neuropathic pain on anxiety- and depressive-like behaviors in rodents, highlighting the importance of investigating sex differences in future experimental studies.

背景流行病学研究经常显示慢性疼痛与焦虑和抑郁症状同时存在，尤其是在女性中。动物模型有助于了解并发症的复杂机制，但所采用的方法种类繁多，证据数量巨大，有时会妨碍有效的转化和可重复性。在这篇系统综述和荟萃分析中，我们旨在综合性别和物种等变量对神经病理性疼痛啮齿类动物模型中焦虑和抑郁样行为影响的证据。结果神经病理性疼痛显著减少了大鼠和小鼠在高架正迷宫和零迷宫开放臂中的停留时间（g = -1.14）、在开放场地中心的停留时间（g = -1.12 ）、蔗糖偏好试验中的蔗糖消耗量（g = -1.43 ）和飞溅试验中的梳理时间（g = -1.37 ），同时增加了新奇感抑制摄食试验中的摄食潜伏期（g = 1.59 ）以及强迫游泳（g = 1.85 ）和尾悬吊（g = 1.91 ）试验中的不动性。结论这项荟萃分析强调了神经性疼痛对啮齿类动物焦虑和抑郁样行为的影响，突出了在未来实验研究中调查性别差异的重要性。

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引用次数: 0

Associations Between Mental Disorders in Donors and Matched Recipients of Hematopoietic Stem Cell Transplants: A Population-Based Cohort Study 造血干细胞移植供体和配型受体精神障碍之间的关系：基于人群的队列研究

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-08-26 DOI: 10.1016/j.bpsgos.2024.100389

Troels Boldt Rømer , Henrik Sengeløv , Rune Haubo Bojesen Christensen , Michael Eriksen Benros

Background

Immunological mechanisms have been implicated in the development of mental disorders, and interestingly, case reports have suggested that hematopoietic stem cell transplantation (HSCT) can both transmit and cure psychotic disorders by replacing immune progenitor cells.

Methods

Using Danish registers, we followed patients who received HSCT from donors with a psychiatric diagnosis or psychotropic medication use. We assessed risk of incident mental disorders or psychotropic medication use compared with recipients with unaffected donors. We identified 464 donor-recipient pairs (51.3% male recipients). All donor-recipient pairs were related.

Results

Receiving HSCT from a donor with a psychiatric history was not significantly associated with incident psychiatric diagnoses (hazard rate ratio [HRR] 2.79, 95% CI, 0.83–9.39; p = .098) or incident use of psychotropics (HRR 1.43, 95% CI, 0.91–2.24; p = .118). Subgroup analysis showed an increased risk of antipsychotic use, which remained significant after adjusting for confounders (HRR 4.73, 95% CI, 1.26–17.78; p = .021); however, this was based on a small number of cases. For depression and antidepressant use, data were available to perform a meta-analysis of our and one additional study, which showed no significant difference (HRR 1.24, 95%, CI 0.66–2.35).

Conclusions

Receiving HSCT from a donor with a psychiatric history did not affect risk of mental disorders. An increased risk of antipsychotic use was observed only in subgroup analyses; however, the exploratory nature of the study, the limited sample size, and family relationship between donors and recipients do not allow for causal conclusions, and external replication studies are warranted.

背景免疫学机制被认为与精神障碍的发生有关，有趣的是，有病例报告表明，造血干细胞移植（HSCT）通过替代免疫祖细胞，既可传播精神障碍，也可治愈精神障碍。与未受影响的供体受者相比，我们评估了发生精神障碍或使用精神药物的风险。我们确定了 464 对供体-受体（51.3% 为男性受体）。结果接受有精神病史捐献者的造血干细胞移植与精神病诊断（危险率比 [HRR] 2.79，95% CI，0.83-9.39；p = .098）或精神药物使用（危险率比 1.43，95% CI，0.91-2.24；p = .118）无显著相关性。亚组分析表明，使用抗精神病药物的风险增加，在调整了混杂因素后仍然显著（HRR 4.73，95% CI，1.26-17.78；p = .021）；然而，这只是基于少数病例。对于抑郁症和抗抑郁药的使用，我们有数据对我们的研究和另外一项研究进行了荟萃分析，结果显示两者无显著差异（HRR 1.24，95%，CI 0.66-2.35）。仅在亚组分析中观察到使用抗精神病药物的风险增加；然而，由于该研究的探索性、样本量有限以及供体和受体之间的家庭关系，因此无法得出因果关系的结论，需要进行外部重复研究。

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引用次数: 0

Sex-Specific Effects of Birth Weight on Longitudinal Behavioral Outcomes: A Mendelian Randomization Approach Using Polygenic Scores 出生体重对纵向行为结果的性别特异性影响：使用多基因评分的孟德尔随机化方法

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-08-26 DOI: 10.1016/j.bpsgos.2024.100387

Lars Meinertz Byg , Carol Wang , John Attia , Andrew Whitehouse , Craig Pennell

Background

It is unclear whether sex differences in behavior arising from birth weight (BW) are genuine because of the cross-sectional nature and potential confounding in previous studies. We aimed to test whether sex differences associated with BW phenotype were reproducible using a Mendelian randomization approach, i.e., association between polygenic score (PGS) for BW and behavior outcomes across childhood and adolescence.

Methods

Using data from the Raine Study, we had 1484 genotyped participants with a total of 6446 Child Behavior Checklist assessments from ages 5 to 17 years. We used BW-PGSs in linear mixed-effect models to predict parentally assessed attention, aggression, and social problems scales; we also derived estimates and significance for a sex-by-genotype interaction. We used a Bonferroni-corrected significance threshold and tested robustness of the results with teacher assessments of behavior and a second PGS.

Results

We found a sex-by-genotype interaction with lower BW-PGSs associated with increased aggression in males compared with females. These findings were consistent across various analyses, including teacher assessments. Surprisingly, a lower BW-PGS showed protective effects in females, while a lower BW phenotype had detrimental effects in males with evidence of a genotype-phenotype mismatch increasing aggression problems in males only.

Conclusions

This study underscores the genuine nature of behavioral sex differences arising from low BW and highlights the sex-dependent and diverging effects of environmental and genetic BW determinants.

背景由于以往研究的横断面性质和潜在混杂因素，出生体重（BW）引起的行为性别差异是否真实尚不清楚。我们的目的是采用孟德尔随机化方法检验与出生体重表型相关的性别差异是否具有可重复性，即出生体重的多基因评分（PGS）与儿童和青少年时期行为结果之间的关联。方法利用雷恩研究（Raine Study）的数据，我们对 1484 名参与者进行了基因分型，并对其 5 至 17 岁期间的 6446 项儿童行为检查表进行了评估。我们在线性混合效应模型中使用 BW-PGS 来预测父母评估的注意力、攻击性和社会问题量表；我们还得出了性别-基因型交互作用的估计值和显著性。我们使用了 Bonferroni 校正的显著性阈值，并通过教师对行为的评估和第二个 PGS 检验了结果的稳健性。结果我们发现了性别-基因型交互作用，与女性相比，较低的 BW-PGS 与男性的攻击性增加有关。这些结果在包括教师评估在内的各种分析中都是一致的。令人惊讶的是，较低的体重-PGS 对女性有保护作用，而较低的体重表型则对男性有不利影响，有证据表明基因型-表型不匹配只会增加男性的攻击性问题。

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引用次数: 0

Modulation of Posterior Default Mode Network Activity During Interoceptive Attention and Relation to Mindfulness 互感注意期间后部默认模式网络活动的调节及其与正念的关系

IF 4 Q2 NEUROSCIENCES

Biological psychiatry global open science

Pub Date : 2024-08-23 DOI: 10.1016/j.bpsgos.2024.100384

Dhakshin Ramanathan , Jason Nan , Gillian Grennan , Satish Jaiswal , Suzanna Purpura , James Manchanda , Vojislav Maric , Pragathi Priyadharsini Balasubramani , Jyoti Mishra

Background

Interoceptive attention to internal sensory signals, such as the breath, is fundamental to mindfulness. However, interoceptive attention can be difficult to study, with many studies relying on subjective and retrospective measures. Response consistency is an established method for evaluating variability of attention on exteroceptive attention tasks, but it has rarely been applied to interoceptive attention tasks.

Methods

In this study, we measured consistency of response times on a breath-monitoring task with simultaneous electroencephalography in individuals across the life span (15–91 years of age, N = 324).

Results

We found that consistency on the breath-monitoring task was positively correlated with attentive performance on an exteroceptive inhibitory control task. Electroencephalography source reconstruction showed that on-task alpha band (8–12 Hz) activity was greater than that measured at rest. Low-consistency/longer breath responses were associated with elevated brain activity compared with high-consistency responses, particularly in posterior default mode network (pDMN) brain regions. pDMN activity was inversely linked with functional connectivity to the frontoparietal network and the cingulo-opercular network on task but not at rest, suggesting a role for these frontal networks in on-task regulation of pDMN activity. pDMN activity within the precuneus region was greater in participants who reported low subjective mindfulness and was adaptively modulated by task difficulty in an independent experiment.

Conclusions

Elevated pDMN alpha activity serves as an objective neural marker for low-consistency responding during interoceptive breath attention, scales with task difficulty, and is associated with low subjective mindfulness.

背景对呼吸等内部感觉信号的感知间注意是正念的基础。然而，感知间注意力很难研究，许多研究都依赖于主观和回顾性测量。在这项研究中，我们用同步脑电图测量了不同年龄段（15-91 岁，N = 324）的人在呼吸监测任务上的反应时间一致性。结果我们发现，呼吸监测任务上的一致性与外感知抑制控制任务上的注意力表现呈正相关。脑电图源重构显示，任务中的α波段（8-12赫兹）活动比休息时测得的活动要强。与高一致性反应相比，低一致性/较长的呼吸反应与大脑活动的升高有关，尤其是在后默认模式网络（pDMN）脑区。pDMN活动与任务中的额顶叶网络和丘脑-小脑网络的功能连通性成反比，但与休息时的功能连通性无关，这表明这些额叶网络在任务中调节pDMN活动的作用。楔前区的pDMN活动在报告主观正念较低的参与者中更大，并且在一项独立实验中受任务难度的调节。

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