Biological psychiatry global open science最新文献

{"title":"A Window of Opportunity: Unraveling How Puberty Relates to Psychotic-Like Experiences During Adolescence","authors":"Mark Curtis","doi":"10.1016/j.bpsgos.2025.100687","DOIUrl":"10.1016/j.bpsgos.2025.100687","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100687"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Occipital-Fronto-Limbic Circuit of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis of Neuroimaging Studies","authors":"Yihui Cheng ,&nbsp;Emalee Burrows ,&nbsp;Ludvic Zrinzo ,&nbsp;Harith Akram ,&nbsp;Trevor W. Robbins ,&nbsp;Himanshu Tyagi","doi":"10.1016/j.bpsgos.2025.100676","DOIUrl":"10.1016/j.bpsgos.2025.100676","url":null,"abstract":"<div><h3>Background</h3><div>Body dysmorphic disorder (BDD) is a severe psychiatric disorder characterized by excessive preoccupation with perceived flaws in appearance. In this review, we aim to synthesize the latest findings on the neurobiology of BDD and propose an updated BDD neurocircuitry model.</div></div><div><h3>Methods</h3><div>A systematic search identified 38 peer-reviewed original articles, and the protocol was registered (<span><span>CRD42024553665</span><svg><path></path></svg></span>). Qualitative thematic analysis was conducted, and activation likelihood estimation (ALE) meta-analysis was performed to quantify brain activation patterns.</div></div><div><h3>Results</h3><div>Brain regions with significant morphometric divergence in patients with BDD were predominantly located in primary and secondary visual processing areas and temporal-limbic and frontal-striatal networks despite overall heterogeneous findings. The electroencephalography studies suggested early visual processing and attentional abnormalities. The ALE analysis revealed a general hyperactivation over the frontotemporal region and hypoactivation over parieto-occipital regions. Although BDD shared similar connectivity patterns in frontostriatal and arbitration networks with obsessive-compulsive disorder, it was further characterized by bottom-up and top-down interaction between the ventral visual stream and temporal-limbic network compared with anorexia nervosa. Neurotransmitters such as serotonin, dopamine, and oxytocin play a key role in the pathophysiology of BDD, suggesting a complex interplay of neural circuits and neurotransmitters underlying the disorder.</div></div><div><h3>Conclusions</h3><div>This comprehensive review of up-to-date neurobiological studies of individuals with BDD reveals differences in brain structure and functionality compared with control participants. The proposed neurocircuitry model expands on the previous understanding of BDD neurobiology and elucidates the interconnection between the visual processing, temporal-limbic, and frontostriatal networks and their clinical implications. This review provides theoretical support for future neuromodulation target identification.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100676"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"μ Opioid Modulation of Sensorimotor Functional Connectivity in Autism: Insights From a Pharmacological Neuroimaging Investigation Using Tianeptine","authors":"Mihail Dimitrov ,&nbsp;Nichol M.L. Wong ,&nbsp;Sydney Leaman ,&nbsp;Lucas G.S. França ,&nbsp;Ioannis Valasakis ,&nbsp;Jason He ,&nbsp;David J. Lythgoe ,&nbsp;James L. Findon ,&nbsp;Robert H. Wichers ,&nbsp;Vladimira Stoencheva ,&nbsp;Dene M. Robertson ,&nbsp;Sarah Blainey ,&nbsp;Glynis Ivin ,&nbsp;Štefan Holiga ,&nbsp;Mark D. Tricklebank ,&nbsp;Dafnis Batalle ,&nbsp;Declan G.M. Murphy ,&nbsp;Gráinne M. McAlonan ,&nbsp;Eileen Daly","doi":"10.1016/j.bpsgos.2025.100663","DOIUrl":"10.1016/j.bpsgos.2025.100663","url":null,"abstract":"<div><h3>Background</h3><div>Reproducible patterns of atypical functional connectivity (FC) of sensorimotor and higher-order networks have previously been identified in the autistic brain. However, the neurosignaling pathways underpinning these differences remain unclear. The μ opioid system is involved in sensory processing as well as social and reward behaviors and has been implicated in autism, suggesting a potential role in shaping the autistic brain. Therefore, we tested the hypothesis that there is atypical involvement of the μ opioid system in these networks in autism.</div></div><div><h3>Methods</h3><div>We used a placebo-controlled, double-blind, randomized, crossover study design to compare the effects of a single dose of the μ opioid receptor agonist tianeptine in autistic (<em>n</em> = 20) and nonautistic (<em>n</em> = 21) males on FC of sensorimotor and frontoparietal networks.</div></div><div><h3>Results</h3><div>We found that tianeptine increased FC of a sensorimotor network previously characterized by atypically low FC in autism. The connectivity of the frontoparietal network was not significantly shifted.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that μ opioid neurosignaling may contribute to functional brain differences in the sensorimotor network in autism. Given that sensorimotor system alterations are thought to be central to autism and contribute to other core autistic features, as well as adaptability and mental health, further research is warranted to explore the translational potential of μ opioid modulation in autism.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100663"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure","authors":"Xiangyu Long ,&nbsp;Catherine Lebel","doi":"10.1016/j.bpsgos.2025.100648","DOIUrl":"10.1016/j.bpsgos.2025.100648","url":null,"abstract":"<div><h3>Background</h3><div>Heavy prenatal alcohol exposure (PAE) is associated with alterations in behavior and cognitive and brain development. However, the effects of low levels of PAE on the brain and behavior remain unclear. In the current study, we aimed to investigate longitudinal changes in the brain and behavior in children with low levels of PAE compared with well-matched unexposed children.</div></div><div><h3>Methods</h3><div>Children (<em>n</em> = 108, mean [SD] = 9.52 [0.50] years at baseline) with PAE (0.97 ± 0.90 drinks/wk) and control children (<em>n</em> = 108, 9.52 [0.50] years at baseline) matched on socioeconomic status were selected from the ABCD (Adolescent Brain Cognitive Development) Study and were followed over 4 years with magnetic resonance imaging and Child Behavior Checklist (CBCL) scores. No children had adverse exposures to other substances.</div></div><div><h3>Results</h3><div>Compared with unexposed children, children with low levels of PAE had persistently higher CBCL scores (worse behavior) and higher intracranial volumes over time.</div></div><div><h3>Conclusions</h3><div>Our results provide further evidence of alterations in the brain and behavior associated with low levels of PAE across early adolescence, highlighting the importance of prevention and early intervention even with low levels of PAE.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100648"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and Prefrontal Circuit Deficits in a Newly Developed Setbp1 Haploinsufficiency Mouse Model","authors":"MacKenzie A. Howard,&nbsp;Mendee A. Geist,&nbsp;Gregory J. Ordemann,&nbsp;Alena Kizimenko,&nbsp;Dominic M. Balice,&nbsp;F. Isaac Guillén,&nbsp;Emmanuella Bassey,&nbsp;Polina Lyuboslavsky,&nbsp;Audrey C. Brumback","doi":"10.1016/j.bpsgos.2025.100666","DOIUrl":"10.1016/j.bpsgos.2025.100666","url":null,"abstract":"<div><h3>Background</h3><div>SET binding protein 1 (<em>SETBP1</em>) regulates the cell cycle, gene transcription, and other vital intracellular processes. <em>SETBP1</em> loss-of-function variants cause the neurodevelopmental disorders <em>SETBP1</em>-haploinsufficiency disorder and <em>SETBP1</em>-related disorders (<em>SETBP1</em>-HD and <em>SETBP1</em>-RD), which are characterized by attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disability/developmental delay, and other neurological disabilities. Here we sought to characterize behavioral, physiological, and cell morphology phenotypes of a newly developed mouse model of <em>SETBP1</em>-HD.</div></div><div><h3>Methods</h3><div>We used open field, 3-chamber, and Y-maze behavioral tests to measure activity, social interest, and spatial learning, respectively. We used whole-cell current clamp recordings from medial prefrontal cortex (mPFC) layer-5 extratelencephalic projection neurons in ex vivo slices to measure cell intrinsic and spike properties. We used morphological reconstruction to measure dendritic arborization in recorded neurons.</div></div><div><h3>Results</h3><div><em>Setbp1</em>^{<em>+/−</em>} mice exhibited hyperactivity, decreased social interest, and increased olfactory exploration in behavioral tests. Ex vivo electrophysiology revealed hypoexcitability in layer-5 extratelencephalic projection neurons in the mPFC. Morphological reconstruction revealed changes to the way branch points and length are distributed within the apical dendritic arbor of these prefrontal pyramidal neurons without changes in overall length or branch number.</div></div><div><h3>Conclusions</h3><div>These data show that <em>Setbp1</em>^{<em>+/−</em>} mice exhibit phenotypes parallel to the ADHD and ASD that are common in patients with <em>SETBP1</em>-HD. Additionally, we identified cellular changes to a key control center for attention, social behavior, and cognitive function that may elucidate the mechanism that underlies the neuropsychiatric disabilities of this disorder.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100666"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parsing Socioeconomic Effects on Treatment Trajectory and Reward Processing in Depression","authors":"Kristina T. Legget","doi":"10.1016/j.bpsgos.2025.100686","DOIUrl":"10.1016/j.bpsgos.2025.100686","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100686"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolism and the Mind: Investigating the Link Between Glucose Control and Reinforcement Learning in Humans","authors":"Hugo Fleming ,&nbsp;Martyna K. Stasiak ,&nbsp;Isabel Lau ,&nbsp;Annalise Whines ,&nbsp;Sara Z. Mehrhof ,&nbsp;Camilla L. Nord","doi":"10.1016/j.bpsgos.2025.100645","DOIUrl":"10.1016/j.bpsgos.2025.100645","url":null,"abstract":"<div><h3>Background</h3><div>Signals from the body profoundly influence cognition. This process is known as interoception, and has been extensively studied in the cardiac, respiratory, and gastric domains; in contrast, metabolic influences remain poorly understood. Here, we focus on the link between glucose control and cognition, motivated by the observation that there is substantial, unexplained comorbidity between type 2 diabetes and depression. In rodents, insulin modulates dopamine signaling in the ventral striatum. We therefore hypothesized that, in humans, differences in glucose control would be associated with altered reward learning.</div></div><div><h3>Methods</h3><div>To test this hypothesis, we recruited 48 participants from the general population, who each completed a glucose tolerance test, a monetary reward learning task known to relate to dopamine function, and mental health questionnaires. We fitted an established reinforcement learning model to the task data to obtain computational parameters characterizing participants’ learning, and then examined the associations between these parameters and their glucose control.</div></div><div><h3>Results</h3><div>We discovered that poorer glucose control was associated with greater reliance on recent rewards during learning, which was in turn associated with higher levels of depression symptoms. There was also more modest evidence for the association between glucose control and depression symptoms.</div></div><div><h3>Conclusions</h3><div>Together, our results identify a specific neurocognitive process, reward learning, by which metabolic information may influence cognition, and which may explain the link between metabolic diseases such as type 2 diabetes and depression.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100645"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Poles: What the Transcranial Magnetic Stimulation Evidence Tells Us About Bipolar Depression","authors":"Véronique Desbeaumes Jodoin","doi":"10.1016/j.bpsgos.2025.100657","DOIUrl":"10.1016/j.bpsgos.2025.100657","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100657"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for Neural Cannabis Cue-Reactivity Studies in Individuals With Cannabis Use Disorder","authors":"Erica N. Grodin ,&nbsp;Kaitlin McManus","doi":"10.1016/j.bpsgos.2025.100669","DOIUrl":"10.1016/j.bpsgos.2025.100669","url":null,"abstract":"","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100669"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Tumor Necrosis Factor Superfamily Members in Neuroinflammatory Schizophrenia and Bipolar Disorder Midbrains","authors":"Gerardo Mendez-Victoriano ,&nbsp;Yunting Zhu ,&nbsp;Layla Neuhaus ,&nbsp;Suhaana Shaik ,&nbsp;Frank Middleton ,&nbsp;Yuji Kondo ,&nbsp;Amir Fayyazuddin ,&nbsp;Daniel Hoeppner ,&nbsp;Sofía Puvogel ,&nbsp;Astrid Alsema ,&nbsp;Laura Kracht ,&nbsp;Mitsuyuki Matsumoto ,&nbsp;Bart J.L. Eggen ,&nbsp;Adam K. Walker ,&nbsp;Maree J. Webster ,&nbsp;Iris E.C. Sommer ,&nbsp;Cynthia S. Weickert","doi":"10.1016/j.bpsgos.2025.100650","DOIUrl":"10.1016/j.bpsgos.2025.100650","url":null,"abstract":"<div><h3>Background</h3><div>Neuroinflammation is a key neuropathological finding in schizophrenia and bipolar disorder, as increased cytokines are found in the midbrain of these individuals. However, the most upregulated inflammatory cytokines and most activated downstream signaling pathway(s) are unidentified.</div></div><div><h3>Methods</h3><div>We aimed to identify the most robust transcriptional change in the schizophrenia midbrain by bulk RNA sequencing (RNA-seq) and to confirm the cellular source and magnitude of change by single-nucleus RNA-seq, reverse transcriptase–polymerase chain reaction (RT-PCR), and immunohistochemistry in 61 healthy controls, 63 schizophrenia cases, and 33 bipolar disorder cases stratified into low- and high-inflammation groups.</div></div><div><h3>Results</h3><div>By RNA-seq, the TNF superfamily (TNFSF) pathway messenger RNAs (mRNAs) were among the most changed in high-inflammation schizophrenia (all <em>p</em>s ≤ .01), with TNFSF receptors (<em>TNFR1</em>, <em>TNFR2</em>, and <em>FAS</em>) being most highly expressed in astrocytes and microglia. Using RT-PCR, we confirmed that 5 TNFSF receptor mRNAs (<em>TNFR</em><em>1</em>, <em>TNFR</em><em>2</em>, <em>DR4</em>, <em>FAS</em>, and <em>TWEAKR</em>, all <em>p</em>s ≤ .01) were increased in high-inflammation schizophrenia/bipolar disorder cases compared with low-inflammation controls. Furthermore, the means for mRNA encoding cell death–related proteins acting downstream of TNF receptors (<em>P53</em>, <em>CASP1</em>, <em>CASP7</em>, <em>CASP8</em>; all <em>p</em>s ≤ .05) were increased in high-inflammation schizophrenia, as were mRNAs encoding proteins regulating cell survival (<em>BCL2</em> and <em>MCL1</em>, all <em>p</em>s ≤ .01). All 5 TNFSF receptor mRNAs positively correlated with effector protein mRNAs (all <em>p</em>s ≤ .05) and with the astrocyte-related marker <em>GFAP</em> mRNA (all <em>p</em>s ≤ .001).</div></div><div><h3>Conclusions</h3><div>Our results suggest that TNFSF transcripts represent the main activated inflammatory pathway in the midbrains of people with schizophrenia, which overlaps somewhat with bipolar disorder. These findings highlight the need for anti-inflammatory interventions targeting TNF/TNFSF receptors to test for therapeutic benefits in psychiatric patients displaying elevated inflammation.</div></div>","PeriodicalId":72373,"journal":{"name":"Biological psychiatry global open science","volume":"6 2","pages":"Article 100650"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}