Pub Date : 2024-10-01DOI: 10.1186/s42490-024-00084-y
Sherif M Elbasiouny
Movement is a central behavior of daily living; thus lost or compromised movement due to disease, injury, or amputation causes enormous loss of productivity and quality of life. While prosthetics have evolved enormously over the years, restoring natural sensorimotor (SM) control via a prosthesis is a difficult problem which neuroengineering has yet to solve. With a focus on upper limb prosthetics, this perspective article discusses the neurophysiology of motor control under healthy conditions and after amputation, the development of upper limb prostheses from early generations to current state-of-the art sensorimotor neuroprostheses, and how postinjury changes could complicate prosthetic control. Current challenges and future development of smart sensorimotor neuroprostheses are also discussed.
{"title":"The neurophysiology of sensorimotor prosthetic control.","authors":"Sherif M Elbasiouny","doi":"10.1186/s42490-024-00084-y","DOIUrl":"10.1186/s42490-024-00084-y","url":null,"abstract":"<p><p>Movement is a central behavior of daily living; thus lost or compromised movement due to disease, injury, or amputation causes enormous loss of productivity and quality of life. While prosthetics have evolved enormously over the years, restoring natural sensorimotor (SM) control via a prosthesis is a difficult problem which neuroengineering has yet to solve. With a focus on upper limb prosthetics, this perspective article discusses the neurophysiology of motor control under healthy conditions and after amputation, the development of upper limb prostheses from early generations to current state-of-the art sensorimotor neuroprostheses, and how postinjury changes could complicate prosthetic control. Current challenges and future development of smart sensorimotor neuroprostheses are also discussed.</p>","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1186/s42490-024-00083-z
Anantha Narayanan Ramakrishnan, Josephine Reymann, Christopher Ludtka, Andreas Kiesow, Stefan Schwan
Background: Restorative solutions designed for edentulous patients such as dentures and their accompanying denture adhesives operate in the complex and dynamic environment represented by human oral physiology. Developing material models accounting for the viscoelastic behavior of denture adhesives can facilitate their further optimization within that unique physiological environment. This study aims to statistically quantify the degree of significance of three physiological variables - namely: temperature, adhesive swelling, and pH - on denture adhesive mechanical behavior. Further, based on these statistical significance estimations, a previously-developed viscoelastic material modelling approach for such denture adhesives is further expanded and developed to capture these variables' effects on mechanical behavior.
Methods: In this study a comparable version of Denture adhesive Corega Comfort was analysed rheologically using the steady state frequency sweep tests. The experimentally derived rheological storage and loss modulus values for the selected physiological variables were statistically analyzed using multi parameter linear regression analysis and the Pearson's coefficient technique to understand the significance of each individual parameter on the relaxation spectrum of the denture adhesive. Subsequently, the parameters are incorporated into a viscoelastic material model based on Prony series discretization and time-temperature superposition, and the mathematical relationship for the loss modulus is deduced.
Results: The results of this study clearly indicated that the variation in both the storage and loss modulus values can be accurately predicted using the oral cavity physiological parameters of temperature, swelling ratio, and pH with an adjusted R2 value of 0.85. The R2 value from the multi-parameter regression analysis indicated that the predictor variables can estimate the loss and storage modulus with a reasonable accuracy for at least 85% of the rheologically determined continuous relaxation spectrum with a confidence level of 98%. The Pearson's coefficient for the independent variables indicated that temperature and swelling have a strong influence on the loss modulus, whereas pH had a weak influence. Based on statistical analysis, these mathematical relationships were further developed in this study.
Conclusions: This multi-parameter viscoelastic material model is intended to facilitate future detailed numerical investigations performed with implementation of denture adhesives using the finite element method.
{"title":"Multi-parameter viscoelastic material model for denture adhesives based on time-temperature superposition and multiple linear regression analysis.","authors":"Anantha Narayanan Ramakrishnan, Josephine Reymann, Christopher Ludtka, Andreas Kiesow, Stefan Schwan","doi":"10.1186/s42490-024-00083-z","DOIUrl":"10.1186/s42490-024-00083-z","url":null,"abstract":"<p><strong>Background: </strong>Restorative solutions designed for edentulous patients such as dentures and their accompanying denture adhesives operate in the complex and dynamic environment represented by human oral physiology. Developing material models accounting for the viscoelastic behavior of denture adhesives can facilitate their further optimization within that unique physiological environment. This study aims to statistically quantify the degree of significance of three physiological variables - namely: temperature, adhesive swelling, and pH - on denture adhesive mechanical behavior. Further, based on these statistical significance estimations, a previously-developed viscoelastic material modelling approach for such denture adhesives is further expanded and developed to capture these variables' effects on mechanical behavior.</p><p><strong>Methods: </strong>In this study a comparable version of Denture adhesive Corega Comfort was analysed rheologically using the steady state frequency sweep tests. The experimentally derived rheological storage and loss modulus values for the selected physiological variables were statistically analyzed using multi parameter linear regression analysis and the Pearson's coefficient technique to understand the significance of each individual parameter on the relaxation spectrum of the denture adhesive. Subsequently, the parameters are incorporated into a viscoelastic material model based on Prony series discretization and time-temperature superposition, and the mathematical relationship for the loss modulus is deduced.</p><p><strong>Results: </strong>The results of this study clearly indicated that the variation in both the storage and loss modulus values can be accurately predicted using the oral cavity physiological parameters of temperature, swelling ratio, and pH with an adjusted R<sup>2</sup> value of 0.85. The R<sup>2</sup> value from the multi-parameter regression analysis indicated that the predictor variables can estimate the loss and storage modulus with a reasonable accuracy for at least 85% of the rheologically determined continuous relaxation spectrum with a confidence level of 98%. The Pearson's coefficient for the independent variables indicated that temperature and swelling have a strong influence on the loss modulus, whereas pH had a weak influence. Based on statistical analysis, these mathematical relationships were further developed in this study.</p><p><strong>Conclusions: </strong>This multi-parameter viscoelastic material model is intended to facilitate future detailed numerical investigations performed with implementation of denture adhesives using the finite element method.</p>","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1186/s42490-024-00082-0
Hamed Mamipour, Seyed Ali Hoseini, Hossein Negahban, Ali Moradi, Amir Hojjati, Fariborz Rezaeitalab, Mohammadreza Torshizian, Arefeh Mehrali, Mohammad Parsa, Iman Kardan, Hamed Tabesh, Ebrahim Ghayem Hassankhani, Alireza Akbarzadeh
Trial design: This study is a pilot randomized clinical trial aimed to investigate the effect of using Hip Exoskeleton Assistive (HEXA) robot compared to conventional physiotherapy on the quality of walking, disability, and quality of life of stroke patients with hemiplegia.
Methods: In this study, 24 patients were randomly assigned to the intervention group (robotic physiotherapy with HEXA robot), or control group (conventional physiotherapy). In each session, both groups received 30 min of conventional physiotherapy including electrotherapy and conventional exercises, and then the intervention group did gait training for 30 min with the HEXA robot and the control group for 30 min without the HEXA robot. The treatment program was 12 sessions, 3 times a week. Before the 1st and after the 12th sessions, both groups were evaluated for walking quality, disability, and quality of life.
Results: The results showed that the main effect of time was significant (P < 0.05) in all outcomes and patients in both groups achieved significant improvement in all outcomes after the intervention. The main effect of the group was also significant in the outcomes of 6MWT (P < 0.05) and TUG (P < 0.05), and the intervention group patients experienced more distance and speed in these two tests. This study was approved by the ethics committee of Mashhad University of Medical Sciences (IR.MUMS.FHMPM.REC.1400.079 dated 28th Jan 2022). The trial was registered with the clinical trials site of www.IRCT.ir (IRCT20210730052024N1) on January 28th 2022.
Conclusion: It seems that the HEXA robot can effectively improve walking capacity and speed.
{"title":"The effect of using the hip exoskeleton assistive (HEXA) robot compared to conventional physiotherapy on clinical functional outcomes in stroke patients with hemiplegia: a pilot randomized controlled trial.","authors":"Hamed Mamipour, Seyed Ali Hoseini, Hossein Negahban, Ali Moradi, Amir Hojjati, Fariborz Rezaeitalab, Mohammadreza Torshizian, Arefeh Mehrali, Mohammad Parsa, Iman Kardan, Hamed Tabesh, Ebrahim Ghayem Hassankhani, Alireza Akbarzadeh","doi":"10.1186/s42490-024-00082-0","DOIUrl":"10.1186/s42490-024-00082-0","url":null,"abstract":"<p><strong>Trial design: </strong>This study is a pilot randomized clinical trial aimed to investigate the effect of using Hip Exoskeleton Assistive (HEXA) robot compared to conventional physiotherapy on the quality of walking, disability, and quality of life of stroke patients with hemiplegia.</p><p><strong>Methods: </strong>In this study, 24 patients were randomly assigned to the intervention group (robotic physiotherapy with HEXA robot), or control group (conventional physiotherapy). In each session, both groups received 30 min of conventional physiotherapy including electrotherapy and conventional exercises, and then the intervention group did gait training for 30 min with the HEXA robot and the control group for 30 min without the HEXA robot. The treatment program was 12 sessions, 3 times a week. Before the 1st and after the 12th sessions, both groups were evaluated for walking quality, disability, and quality of life.</p><p><strong>Results: </strong>The results showed that the main effect of time was significant (P < 0.05) in all outcomes and patients in both groups achieved significant improvement in all outcomes after the intervention. The main effect of the group was also significant in the outcomes of 6MWT (P < 0.05) and TUG (P < 0.05), and the intervention group patients experienced more distance and speed in these two tests. This study was approved by the ethics committee of Mashhad University of Medical Sciences (IR.MUMS.FHMPM.REC.1400.079 dated 28th Jan 2022). The trial was registered with the clinical trials site of www.IRCT.ir (IRCT20210730052024N1) on January 28th 2022.</p><p><strong>Conclusion: </strong>It seems that the HEXA robot can effectively improve walking capacity and speed.</p>","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1186/s42490-024-00081-1
Bahar Tajadini, Saeid R Seydnejad, Soheila Rezakhani
This article aims to provide and implement a patient-specific seizure (for Intervention Time (IT) detection) prediction algorithm using non-invasive data to develop warning devices to prevent further patient injury and reduce stress. Employing algorithms with high initial data volume and computations time to increase the accuracy is an important problem in prediction issues. Consequently, reduction of calculations is met by applying only two effective EEG signal channels without manual removal of artifacts by visual inspection as the algorithm's input. Autoregression (AR) modeling and Cepstrum detect changes due to IT period. We carry out the goal of higher accuracy by increasing sensitivity to interictal epileptiform discharges or artifacts and reduce errors caused by them, taking advantage of the discrete wavelet transform and the comparison of two channels epochs by applying the median filter. Averaging and positive envelope methods are introduced to patient-specific thresholds become more differentiated as soon as possible and can be lead to sooner prediction. We examined this method on a mathematical model of adult epilepsy as well as on 10 patients with EEG data. The results of our experiments confirm that performance of the proposed approach in accuracy and average false prediction rate is superior to other algorithms. Simulation results have been shown the robustness of our proposed method to artifacts and errors, which is a step towards the development of real-time alarm devices by non-invasive techniques.
本文旨在利用无创数据提供并实施一种针对特定患者的癫痫发作(干预时间(IT)检测)预测算法,以开发预警设备,防止对患者造成进一步伤害并减轻压力。采用初始数据量大、计算时间长的算法来提高准确性是预测问题中的一个重要问题。因此,通过仅应用两个有效的脑电信号通道,而不通过目视检查手动去除伪影作为算法输入,可以减少计算量。自回归(AR)建模和倒频谱(Cepstrum)可检测 IT 期间的变化。我们通过提高对发作间期癫痫样放电或伪像的敏感性来实现更高精度的目标,并利用离散小波变换和应用中值滤波器对两个通道的历时进行比较,减少由它们引起的误差。平均法和正包络法的引入使患者特定的阈值尽快得到区分,并能更快地进行预测。我们在一个成人癫痫数学模型以及 10 名患者的脑电图数据上检验了这种方法。实验结果证实,所提出的方法在准确率和平均错误预测率方面都优于其他算法。仿真结果表明,我们提出的方法对伪影和误差具有鲁棒性,这为利用无创技术开发实时报警设备迈出了一步。
{"title":"Short-term epileptic seizures prediction based on cepstrum analysis and signal morphology.","authors":"Bahar Tajadini, Saeid R Seydnejad, Soheila Rezakhani","doi":"10.1186/s42490-024-00081-1","DOIUrl":"10.1186/s42490-024-00081-1","url":null,"abstract":"<p><p>This article aims to provide and implement a patient-specific seizure (for Intervention Time (IT) detection) prediction algorithm using non-invasive data to develop warning devices to prevent further patient injury and reduce stress. Employing algorithms with high initial data volume and computations time to increase the accuracy is an important problem in prediction issues. Consequently, reduction of calculations is met by applying only two effective EEG signal channels without manual removal of artifacts by visual inspection as the algorithm's input. Autoregression (AR) modeling and Cepstrum detect changes due to IT period. We carry out the goal of higher accuracy by increasing sensitivity to interictal epileptiform discharges or artifacts and reduce errors caused by them, taking advantage of the discrete wavelet transform and the comparison of two channels epochs by applying the median filter. Averaging and positive envelope methods are introduced to patient-specific thresholds become more differentiated as soon as possible and can be lead to sooner prediction. We examined this method on a mathematical model of adult epilepsy as well as on 10 patients with EEG data. The results of our experiments confirm that performance of the proposed approach in accuracy and average false prediction rate is superior to other algorithms. Simulation results have been shown the robustness of our proposed method to artifacts and errors, which is a step towards the development of real-time alarm devices by non-invasive techniques.</p>","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1186/s42490-024-00079-9
Christopher Gibson, Shirley C Wang, Arcturus Phoon, Nayana Thalanki Anantha, Kathryn Ottolino-Perry, Stephen Petropoulos, Zuha Qureshi, Vasanth Subramanian, Anam Shahid, Cristiana O'Brien, Steven Carcone, Suzanne Chung, Teresa Tsui, Viktor Son, Mayleen Sukhram, Fannong Meng, Susan J Done, Alexandra M Easson, Tulin Cil, Michael Reedijk, Wey L Leong, Ralph S DaCosta
Background: Visualization of cancer during breast conserving surgery (BCS) remains challenging; the BCS reoperation rate is reported to be 20-70% of patients. An urgent clinical need exists for real-time intraoperative visualization of breast carcinomas during BCS. We previously demonstrated the ability of a prototype imaging device to identify breast carcinoma in excised surgical specimens following 5-aminolevulinic acid (5-ALA) administration. However, this prototype device was not designed to image the surgical cavity for remaining carcinoma after the excised lumpectomy specimen is removed. A new handheld fluorescence (FL) imaging prototype device, designed to image both excised specimens and within the surgical cavity, was assessed in a clinical trial to evaluate its clinical utility for first-in-human, real-time intraoperative imaging during index BCS.
Results: The imaging device combines consumer-grade imaging sensory technology with miniature light-emitting diodes (LEDs) and multiband optical filtering to capture high-resolution white light (WL) and FL digital images and videos. The technology allows for visualization of protoporphyrin IX (PpIX), which fluoresces red when excited by violet-blue light. To date, patients have received bodyweight (BW) 5-ALA orally 2-4 h before imaging to facilitate the accumulation of PpIX within tumour cells. Tissue types were identified based on their colour appearance. Breast tumours in sectioned lumpectomies appeared red, which contrasted against the green connective tissues and orange-brown adipose tissues. In addition, ductal carcinoma in situ (DCIS) that was missed during intraoperative standard of care was identified at the surgical margin at <1 mm depth. In addition, artifacts due to the surgical drape, illumination, and blood within the surgical cavity were discovered.
Conclusions: This study has demonstrated the detection of a grossly occult positive margin intraoperatively. Artifacts from imaging within the surgical cavity have been identified, and potential mitigations have been proposed.
Trial registration: ClinicalTrials.gov Identifier: NCT01837225 (Trial start date is September 2010. It was registered to ClinicalTrials.gov retrospectively on April 23, 2013, then later updated on April 9, 2020, to reflect the introduction of the new imaging device.).
{"title":"A handheld device for intra-cavity and ex vivo fluorescence imaging of breast conserving surgery margins with 5-aminolevulinic acid.","authors":"Christopher Gibson, Shirley C Wang, Arcturus Phoon, Nayana Thalanki Anantha, Kathryn Ottolino-Perry, Stephen Petropoulos, Zuha Qureshi, Vasanth Subramanian, Anam Shahid, Cristiana O'Brien, Steven Carcone, Suzanne Chung, Teresa Tsui, Viktor Son, Mayleen Sukhram, Fannong Meng, Susan J Done, Alexandra M Easson, Tulin Cil, Michael Reedijk, Wey L Leong, Ralph S DaCosta","doi":"10.1186/s42490-024-00079-9","DOIUrl":"10.1186/s42490-024-00079-9","url":null,"abstract":"<p><strong>Background: </strong>Visualization of cancer during breast conserving surgery (BCS) remains challenging; the BCS reoperation rate is reported to be 20-70% of patients. An urgent clinical need exists for real-time intraoperative visualization of breast carcinomas during BCS. We previously demonstrated the ability of a prototype imaging device to identify breast carcinoma in excised surgical specimens following 5-aminolevulinic acid (5-ALA) administration. However, this prototype device was not designed to image the surgical cavity for remaining carcinoma after the excised lumpectomy specimen is removed. A new handheld fluorescence (FL) imaging prototype device, designed to image both excised specimens and within the surgical cavity, was assessed in a clinical trial to evaluate its clinical utility for first-in-human, real-time intraoperative imaging during index BCS.</p><p><strong>Results: </strong>The imaging device combines consumer-grade imaging sensory technology with miniature light-emitting diodes (LEDs) and multiband optical filtering to capture high-resolution white light (WL) and FL digital images and videos. The technology allows for visualization of protoporphyrin IX (PpIX), which fluoresces red when excited by violet-blue light. To date, <math><mrow><mi>n</mi> <mo>=</mo> <mn>17</mn></mrow> </math> patients have received <math><mrow><mn>20</mn> <mfrac><mtext>mg</mtext> <mtext>kg</mtext></mfrac> </mrow> </math> bodyweight (BW) 5-ALA orally 2-4 h before imaging to facilitate the accumulation of PpIX within tumour cells. Tissue types were identified based on their colour appearance. Breast tumours in sectioned lumpectomies appeared red, which contrasted against the green connective tissues and orange-brown adipose tissues. In addition, ductal carcinoma in situ (DCIS) that was missed during intraoperative standard of care was identified at the surgical margin at <1 mm depth. In addition, artifacts due to the surgical drape, illumination, and blood within the surgical cavity were discovered.</p><p><strong>Conclusions: </strong>This study has demonstrated the detection of a grossly occult positive margin intraoperatively. Artifacts from imaging within the surgical cavity have been identified, and potential mitigations have been proposed.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT01837225 (Trial start date is September 2010. It was registered to ClinicalTrials.gov retrospectively on April 23, 2013, then later updated on April 9, 2020, to reflect the introduction of the new imaging device.).</p>","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-02DOI: 10.1186/s42490-024-00080-2
Seif Eldawlatly
Since their inception more than 50 years ago, Brain-Computer Interfaces (BCIs) have held promise to compensate for functions lost by people with disabilities through allowing direct communication between the brain and external devices. While research throughout the past decades has demonstrated the feasibility of BCI to act as a successful assistive technology, the widespread use of BCI outside the lab is still beyond reach. This can be attributed to a number of challenges that need to be addressed for BCI to be of practical use including limited data availability, limited temporal and spatial resolutions of brain signals recorded non-invasively and inter-subject variability. In addition, for a very long time, BCI development has been mainly confined to specific simple brain patterns, while developing other BCI applications relying on complex brain patterns has been proven infeasible. Generative Artificial Intelligence (GAI) has recently emerged as an artificial intelligence domain in which trained models can be used to generate new data with properties resembling that of available data. Given the enhancements observed in other domains that possess similar challenges to BCI development, GAI has been recently employed in a multitude of BCI development applications to generate synthetic brain activity; thereby, augmenting the recorded brain activity. Here, a brief review of the recent adoption of GAI techniques to overcome the aforementioned BCI challenges is provided demonstrating the enhancements achieved using GAI techniques in augmenting limited EEG data, enhancing the spatiotemporal resolution of recorded EEG data, enhancing cross-subject performance of BCI systems and implementing end-to-end BCI applications. GAI could represent the means by which BCI would be transformed into a prevalent assistive technology, thereby improving the quality of life of people with disabilities, and helping in adopting BCI as an emerging human-computer interaction technology for general use.
{"title":"On the role of generative artificial intelligence in the development of brain-computer interfaces","authors":"Seif Eldawlatly","doi":"10.1186/s42490-024-00080-2","DOIUrl":"https://doi.org/10.1186/s42490-024-00080-2","url":null,"abstract":"Since their inception more than 50 years ago, Brain-Computer Interfaces (BCIs) have held promise to compensate for functions lost by people with disabilities through allowing direct communication between the brain and external devices. While research throughout the past decades has demonstrated the feasibility of BCI to act as a successful assistive technology, the widespread use of BCI outside the lab is still beyond reach. This can be attributed to a number of challenges that need to be addressed for BCI to be of practical use including limited data availability, limited temporal and spatial resolutions of brain signals recorded non-invasively and inter-subject variability. In addition, for a very long time, BCI development has been mainly confined to specific simple brain patterns, while developing other BCI applications relying on complex brain patterns has been proven infeasible. Generative Artificial Intelligence (GAI) has recently emerged as an artificial intelligence domain in which trained models can be used to generate new data with properties resembling that of available data. Given the enhancements observed in other domains that possess similar challenges to BCI development, GAI has been recently employed in a multitude of BCI development applications to generate synthetic brain activity; thereby, augmenting the recorded brain activity. Here, a brief review of the recent adoption of GAI techniques to overcome the aforementioned BCI challenges is provided demonstrating the enhancements achieved using GAI techniques in augmenting limited EEG data, enhancing the spatiotemporal resolution of recorded EEG data, enhancing cross-subject performance of BCI systems and implementing end-to-end BCI applications. GAI could represent the means by which BCI would be transformed into a prevalent assistive technology, thereby improving the quality of life of people with disabilities, and helping in adopting BCI as an emerging human-computer interaction technology for general use.","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-23DOI: 10.1186/s42490-024-00078-w
Azza Naïja, O. Mutlu, Talha Khan, Thomas Daniel Seers, Huseyin C Yalcin
{"title":"An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages","authors":"Azza Naïja, O. Mutlu, Talha Khan, Thomas Daniel Seers, Huseyin C Yalcin","doi":"10.1186/s42490-024-00078-w","DOIUrl":"https://doi.org/10.1186/s42490-024-00078-w","url":null,"abstract":"","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-11DOI: 10.1186/s42490-024-00076-y
Carlos A. Reynoso-Mejia, Jonathan Troville, Martin G. Wagner, Bernice Hoppel, Fred T. Lee, Timothy P. Szczykutowicz
MAR algorithms have not been productized in interventional imaging because they are too time-consuming. Application of a beam hardening filter can mitigate metal artifacts and doesn’t increase computational burden. We evaluate the ability to reduce metal artifacts of a 0.5 mm silver (Ag) additional filter in a Multidetector Computed Tomography (MDCT) scanner during CT-guided biopsy procedures. A biopsy needle was positioned inside the lung field of an anthropomorphic phantom (Lungman, Kyoto Kagaku, Kyoto, Japan). CT acquisitions were performed with beam energies of 100 kV, 120 kV, 135 kV, and 120 kV with the Ag filter and reconstructed using a filtered back projection algorithm. For each measurement, the CTDIvol was kept constant at 1 mGy. Quantitative profiles placed in three regions of the artifact (needle, needle tip, and trajectory artifacts) were used to obtain metrics (FWHM, FWTM, width at − 100 HU, and absolute error in HU) to evaluate the blooming artifact, artifact width, change in CT number, and artifact range. An image quality analysis was carried out through image noise measurement. A one-way analysis of variance (ANOVA) test was used to find significant differences between the conventional CT beam energies and the Ag filtered 120 kV beam. The 120 kV-Ag is shown to have the shortest range of artifacts compared to the other beam energies. For needle tip and trajectory artifacts, a significant reduction of − 53.6% (p < 0.001) and − 48.7% (p < 0.001) in the drop of the CT number was found, respectively, in comparison with the reference beam of 120 kV as well as a significant decrease of up to − 34.7% in the artifact width (width at − 100 HU, p < 0.001). Also, a significant reduction in the blooming artifact of − 14.2% (FWHM, p < 0.001) and − 53.3% (FWTM, p < 0.001) was found in the needle artifact. No significant changes (p > 0.05) in image noise between the conventional energies and the 120 kV-Ag were found. A 0.5 mm Ag additional MDCT filter demonstrated consistent metal artifact reduction generated by the biopsy needle. This reduction may lead to a better depiction of the target and surrounding structures while maintaining image quality.
由于 MAR 算法过于耗时,因此尚未在介入成像中实现产品化。应用光束硬化滤波器可以减少金属伪影,而且不会增加计算负担。我们评估了 0.5 毫米银(Ag)附加滤波器在多载体计算机断层扫描(MDCT)扫描仪上进行 CT 引导活检过程中减少金属伪影的能力。活检针被放置在一个拟人化模型(Lungman,日本京都 Kagaku 公司)的肺野内。CT 采集在 100 kV、120 kV、135 kV 和 120 kV 的光束能量和 Ag 滤波器下进行,并使用滤波背投影算法进行重建。每次测量时,CTDIvol 都保持在 1 mGy。在伪影的三个区域(针、针尖和轨迹伪影)放置定量剖面图,以获得度量指标(FWHM、FWTM、- 100 HU 时的宽度和 HU 绝对误差),从而评估开花伪影、伪影宽度、CT 数变化和伪影范围。通过图像噪声测量进行图像质量分析。采用单因素方差分析(ANOVA)检验来发现传统 CT 光束能量与经过 Ag 滤波的 120 kV 光束之间的显著差异。结果表明,与其他光束能量相比,120 kV-Ag光束的伪影范围最短。在针尖和轨迹伪影方面,传统能量与 120 kV-Ag 相比,图像噪声显著降低了 - 53.6% (p 0.05)。0.5 毫米银质附加 MDCT 过滤器显示,活检针产生的金属伪影持续减少。这种减少可能会在保持图像质量的同时更好地描述目标和周围结构。
{"title":"Needle artifact reduction during interventional CT procedures using a silver filter","authors":"Carlos A. Reynoso-Mejia, Jonathan Troville, Martin G. Wagner, Bernice Hoppel, Fred T. Lee, Timothy P. Szczykutowicz","doi":"10.1186/s42490-024-00076-y","DOIUrl":"https://doi.org/10.1186/s42490-024-00076-y","url":null,"abstract":"MAR algorithms have not been productized in interventional imaging because they are too time-consuming. Application of a beam hardening filter can mitigate metal artifacts and doesn’t increase computational burden. We evaluate the ability to reduce metal artifacts of a 0.5 mm silver (Ag) additional filter in a Multidetector Computed Tomography (MDCT) scanner during CT-guided biopsy procedures. A biopsy needle was positioned inside the lung field of an anthropomorphic phantom (Lungman, Kyoto Kagaku, Kyoto, Japan). CT acquisitions were performed with beam energies of 100 kV, 120 kV, 135 kV, and 120 kV with the Ag filter and reconstructed using a filtered back projection algorithm. For each measurement, the CTDIvol was kept constant at 1 mGy. Quantitative profiles placed in three regions of the artifact (needle, needle tip, and trajectory artifacts) were used to obtain metrics (FWHM, FWTM, width at − 100 HU, and absolute error in HU) to evaluate the blooming artifact, artifact width, change in CT number, and artifact range. An image quality analysis was carried out through image noise measurement. A one-way analysis of variance (ANOVA) test was used to find significant differences between the conventional CT beam energies and the Ag filtered 120 kV beam. The 120 kV-Ag is shown to have the shortest range of artifacts compared to the other beam energies. For needle tip and trajectory artifacts, a significant reduction of − 53.6% (p < 0.001) and − 48.7% (p < 0.001) in the drop of the CT number was found, respectively, in comparison with the reference beam of 120 kV as well as a significant decrease of up to − 34.7% in the artifact width (width at − 100 HU, p < 0.001). Also, a significant reduction in the blooming artifact of − 14.2% (FWHM, p < 0.001) and − 53.3% (FWTM, p < 0.001) was found in the needle artifact. No significant changes (p > 0.05) in image noise between the conventional energies and the 120 kV-Ag were found. A 0.5 mm Ag additional MDCT filter demonstrated consistent metal artifact reduction generated by the biopsy needle. This reduction may lead to a better depiction of the target and surrounding structures while maintaining image quality.","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140099240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-17DOI: 10.1186/s42490-024-00075-z
Basak Olcay, Gizem D. Ozdemir, Mehmet A. Ozdemir, Utku K. Ercan, Onan Guren, Ozan Karaman
Infectious diseases not only cause severe health problems but also burden the healthcare system. Therefore, the effective treatment of those diseases is crucial. Both conventional approaches, such as antimicrobial agents, and novel approaches, like antimicrobial peptides (AMPs), are used to treat infections. However, due to the drawbacks of current approaches, new solutions are still being investigated. One recent approach is the use of AMPs and antimicrobial agents in combination, but determining synergism is with a huge variety of AMPs time-consuming and requires multiple experimental studies. Machine learning (ML) algorithms are widely used to predict biological outcomes, particularly in the field of AMPs, but no previous research reported on predicting the synergistic effects of AMPs and antimicrobial agents. Several supervised ML models were implemented to accurately predict the synergistic effect of AMPs and antimicrobial agents. The results demonstrated that the hyperparameter-optimized Light Gradient Boosted Machine Classifier (oLGBMC) yielded the best test accuracy of 76.92% for predicting the synergistic effect. Besides, the feature importance analysis reveals that the target microbial species, the minimum inhibitory concentrations (MICs) of the AMP and the antimicrobial agents, and the used antimicrobial agent were the most important features for the prediction of synergistic effect, which aligns with recent experimental studies in the literature. This study reveals that ML algorithms can predict the synergistic activity of two different antimicrobial agents without the need for complex and time-consuming experimental procedures. The implications support that the ML models may not only reduce the experimental cost but also provide validation of experimental procedures.
传染病不仅会造成严重的健康问题,还会给医疗系统带来负担。因此,有效治疗这些疾病至关重要。传统方法(如抗菌剂)和新型方法(如抗菌肽)都被用于治疗感染。然而,由于目前的方法存在缺陷,新的解决方案仍在研究之中。最近的一种方法是将 AMPs 和抗菌剂结合使用,但确定 AMPs 的协同作用非常耗时,需要进行多次实验研究。机器学习(ML)算法被广泛用于预测生物学结果,特别是在 AMPs 领域,但以前没有关于预测 AMPs 和抗菌剂协同作用的研究报告。为了准确预测 AMPs 和抗菌剂的协同效应,我们采用了几种有监督的 ML 模型。结果表明,超参数优化光梯度提升机分类器(oLGBMC)预测协同效应的测试准确率最高,达到 76.92%。此外,特征重要性分析表明,目标微生物种类、AMP 和抗菌剂的最低抑菌浓度(MICs)以及使用的抗菌剂是预测协同效应的最重要特征,这与近期文献中的实验研究结果一致。本研究揭示了 ML 算法可以预测两种不同抗菌剂的协同活性,而无需复杂耗时的实验过程。这表明 ML 模型不仅能降低实验成本,还能验证实验过程。
{"title":"Prediction of the synergistic effect of antimicrobial peptides and antimicrobial agents via supervised machine learning","authors":"Basak Olcay, Gizem D. Ozdemir, Mehmet A. Ozdemir, Utku K. Ercan, Onan Guren, Ozan Karaman","doi":"10.1186/s42490-024-00075-z","DOIUrl":"https://doi.org/10.1186/s42490-024-00075-z","url":null,"abstract":"Infectious diseases not only cause severe health problems but also burden the healthcare system. Therefore, the effective treatment of those diseases is crucial. Both conventional approaches, such as antimicrobial agents, and novel approaches, like antimicrobial peptides (AMPs), are used to treat infections. However, due to the drawbacks of current approaches, new solutions are still being investigated. One recent approach is the use of AMPs and antimicrobial agents in combination, but determining synergism is with a huge variety of AMPs time-consuming and requires multiple experimental studies. Machine learning (ML) algorithms are widely used to predict biological outcomes, particularly in the field of AMPs, but no previous research reported on predicting the synergistic effects of AMPs and antimicrobial agents. Several supervised ML models were implemented to accurately predict the synergistic effect of AMPs and antimicrobial agents. The results demonstrated that the hyperparameter-optimized Light Gradient Boosted Machine Classifier (oLGBMC) yielded the best test accuracy of 76.92% for predicting the synergistic effect. Besides, the feature importance analysis reveals that the target microbial species, the minimum inhibitory concentrations (MICs) of the AMP and the antimicrobial agents, and the used antimicrobial agent were the most important features for the prediction of synergistic effect, which aligns with recent experimental studies in the literature. This study reveals that ML algorithms can predict the synergistic activity of two different antimicrobial agents without the need for complex and time-consuming experimental procedures. The implications support that the ML models may not only reduce the experimental cost but also provide validation of experimental procedures.","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139483221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-11DOI: 10.1186/s42490-023-00074-6
Bethel Osuagwu, Euan McCaughey, Mariel Purcell
Background: A pressure ulcer (PU) is a debilitating condition that disproportionately affects people with impaired mobility. PUs facilitate tissue damage due to prolonged unrelieved pressure, degrading quality of life with a considerable socio-economic impact. While rapid treatment is crucial, an effective prevention strategy may help avoid the development of PUs altogether. While pressure monitoring is currently used in PU prevention, available monitoring approaches are not formalised and do not appropriately account for accumulation and relief of the effect of an applied pressure over a prolonged duration. The aim of this study was to define an approach that incorporates the accumulation and relief of an applied load to enable continuous pressure monitoring.
Results: A tunable continuous pressure magnitude and duration monitoring approach that can account for accumulated damaging effect of an applied pressure and pressure relief over a prolonged period is proposed. Unlike classic pressure monitoring approaches, the presented method provides ongoing indication of the net impact of a load during and after loading.
Conclusions: The tunable continuous pressure magnitude and duration monitoring approach proposed here may further development towards formalised pressure monitoring approaches that aim to provide information on the risk of PU formation in real-time.
{"title":"A pressure monitoring approach for pressure ulcer prevention.","authors":"Bethel Osuagwu, Euan McCaughey, Mariel Purcell","doi":"10.1186/s42490-023-00074-6","DOIUrl":"10.1186/s42490-023-00074-6","url":null,"abstract":"<p><strong>Background: </strong>A pressure ulcer (PU) is a debilitating condition that disproportionately affects people with impaired mobility. PUs facilitate tissue damage due to prolonged unrelieved pressure, degrading quality of life with a considerable socio-economic impact. While rapid treatment is crucial, an effective prevention strategy may help avoid the development of PUs altogether. While pressure monitoring is currently used in PU prevention, available monitoring approaches are not formalised and do not appropriately account for accumulation and relief of the effect of an applied pressure over a prolonged duration. The aim of this study was to define an approach that incorporates the accumulation and relief of an applied load to enable continuous pressure monitoring.</p><p><strong>Results: </strong>A tunable continuous pressure magnitude and duration monitoring approach that can account for accumulated damaging effect of an applied pressure and pressure relief over a prolonged period is proposed. Unlike classic pressure monitoring approaches, the presented method provides ongoing indication of the net impact of a load during and after loading.</p><p><strong>Conclusions: </strong>The tunable continuous pressure magnitude and duration monitoring approach proposed here may further development towards formalised pressure monitoring approaches that aim to provide information on the risk of PU formation in real-time.</p>","PeriodicalId":72425,"journal":{"name":"BMC biomedical engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9986790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}