Merve Pamukçuoğlu, M. S. Pepeler, Burcu Ülküden, G. Pu, N. Akyürek, Ş. Akı, G. Sucak
Myeloid sarcoma (MS), chloroma and granulositic sarcoma (GS) are all used to describe tumours which proliferate as a result of blasts in the extramedullary parts of the body [1]. Chloroma took its’name from the colour of the tumour [1,2]. It is usually green [1] Granulositic sarcoma occurs in Myelodysplastic syndrome (MDS), Chronic Myelocyter Leukemia (CML) and in 2-8% of AML patients, at a younger age [3,4]. İt usually seen at 1-81 years of age and the size of GS can be from 2 to 20 cm [1]. Compression symptoms of pain and bleeding were as a result of the mass effect of GS. We determined the localizing of mass by Positron emission tomography with fluoroD-glucose integrated with computed tomography (FDG-PET CT) [1,5]. Mass is of containing immature granulocytic series cells and also pathological examination is very difficult [6]. There are three pathologic groups. Group-1 predominantly contains myeloblasts which are poorly differentiated. Group -2 contains moderately differentiated myeloblasts and promyelosites. Promyelosites are dominant. Group-3 contains an equal value of well matured promyelosites and myelosites [4]. Mitotic activity is very different in GS. Kİ-67/MIB1 score was always high (50%95%) [1,7]. When we take a biopsy from a different part of the tumor mitotic activity can change [4]. Single body macrophage demonstrates faster tumor cell turnover [4], but GS does not always have uniform structure nor uniform chromosomal anomalies [4,7].
{"title":"Occurrence of granulocytic sarcoma after allogenic hematopoietic stem cell transplantation","authors":"Merve Pamukçuoğlu, M. S. Pepeler, Burcu Ülküden, G. Pu, N. Akyürek, Ş. Akı, G. Sucak","doi":"10.33425/2639-8478.1005","DOIUrl":"https://doi.org/10.33425/2639-8478.1005","url":null,"abstract":"Myeloid sarcoma (MS), chloroma and granulositic sarcoma (GS) are all used to describe tumours which proliferate as a result of blasts in the extramedullary parts of the body [1]. Chloroma took its’name from the colour of the tumour [1,2]. It is usually green [1] Granulositic sarcoma occurs in Myelodysplastic syndrome (MDS), Chronic Myelocyter Leukemia (CML) and in 2-8% of AML patients, at a younger age [3,4]. İt usually seen at 1-81 years of age and the size of GS can be from 2 to 20 cm [1]. Compression symptoms of pain and bleeding were as a result of the mass effect of GS. We determined the localizing of mass by Positron emission tomography with fluoroD-glucose integrated with computed tomography (FDG-PET CT) [1,5]. Mass is of containing immature granulocytic series cells and also pathological examination is very difficult [6]. There are three pathologic groups. Group-1 predominantly contains myeloblasts which are poorly differentiated. Group -2 contains moderately differentiated myeloblasts and promyelosites. Promyelosites are dominant. Group-3 contains an equal value of well matured promyelosites and myelosites [4]. Mitotic activity is very different in GS. Kİ-67/MIB1 score was always high (50%95%) [1,7]. When we take a biopsy from a different part of the tumor mitotic activity can change [4]. Single body macrophage demonstrates faster tumor cell turnover [4], but GS does not always have uniform structure nor uniform chromosomal anomalies [4,7].","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"1 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43993787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ando, Mayumi Yamamoto, Yasuyoshi Ninosaka, K. Okamura
In these days in Japan, the number of elders is increasing rapidly and many will be die in near future. Home hospice is one of the facilities where they spend their final stage. In Japan the Ministry of Health, Labour and Welfare has recommended the expansion of equality for accessibility of care [1]. However, since home hospice has just begun rapidly in Japan, there are few a formal psychological or spiritual care.
{"title":"A pilot study of narrative approach for terminally ill cancer patient at home hospice","authors":"M. Ando, Mayumi Yamamoto, Yasuyoshi Ninosaka, K. Okamura","doi":"10.15761/CCRR.1000383","DOIUrl":"https://doi.org/10.15761/CCRR.1000383","url":null,"abstract":"In these days in Japan, the number of elders is increasing rapidly and many will be die in near future. Home hospice is one of the facilities where they spend their final stage. In Japan the Ministry of Health, Labour and Welfare has recommended the expansion of equality for accessibility of care [1]. However, since home hospice has just begun rapidly in Japan, there are few a formal psychological or spiritual care.","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67444417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The epidemic of overweight and obesity in youth is increasing the prevalence of prehypertension and hypertension among children and adolescents. The younger the child is at presentation and the more severe the blood pressure abnormality, the more likely a secondary cause of hypertension to be present. Measurement of blood pressure (BP) in children requires adaptation to the age and size of the children. Interpretation must be related to normative values specific to age, gender and height. Evaluation is primarily aimed at identifying secondary causes of hypertension, associated comorbidities, additional risk factors, and evidence of target organ damage. Ambulatory blood pressure monitoring is emerging as a useful tool for evaluation of some patients, particularly for those with suspected white coat hypertension. Uncontrolled and prolonged elevation of blood pressure can lead to a variety of changes in the myocardial structure, coronary vasculature, and conduction system of the heart. These changes in turn can lead to the development of left ventricular hypertrophy, coronary artery disease, various conduction system diseases, and systolic and diastolic dysfunction of the myocardium, cardiac arrhythmias (especially atrial fibrillation), and congestive heart failure. Although these diseases generally develop in response to chronically elevated BP, marked and acute elevation of BP can lead to accentuation of an underlying predisposition to any of the symptoms traditionally associated with chronic hypertension. Management of prehypertension and hypertension is directed at the underlying cause, exacerbating factors, and the magnitude of the blood pressure abnormality. Healthy behavioral changes are a primary management tool for treating hypertension, and more particularly prehypertension and for addressing other cardiovascular risk factors, such as obesity. Pharmacological management is reserved for patients with hypertension who do not respond to behavioral changes, have additional cardiovascular risk factors or diabetes, are symptomatic or have developed target organ damage. Correspondence to: Manal Fuad Elshamaa, Pediatrics Department &Echocardiography Clinic, National Research Centre, Cairo, Egypt, E-mail: manal_elshmaa@hotmail.com
{"title":"Hypertension and Hypertensive Heart Disease in Children and Adolescents","authors":"M. F. Elshamaa","doi":"10.15761/ccrr.1000384","DOIUrl":"https://doi.org/10.15761/ccrr.1000384","url":null,"abstract":"The epidemic of overweight and obesity in youth is increasing the prevalence of prehypertension and hypertension among children and adolescents. The younger the child is at presentation and the more severe the blood pressure abnormality, the more likely a secondary cause of hypertension to be present. Measurement of blood pressure (BP) in children requires adaptation to the age and size of the children. Interpretation must be related to normative values specific to age, gender and height. Evaluation is primarily aimed at identifying secondary causes of hypertension, associated comorbidities, additional risk factors, and evidence of target organ damage. Ambulatory blood pressure monitoring is emerging as a useful tool for evaluation of some patients, particularly for those with suspected white coat hypertension. Uncontrolled and prolonged elevation of blood pressure can lead to a variety of changes in the myocardial structure, coronary vasculature, and conduction system of the heart. These changes in turn can lead to the development of left ventricular hypertrophy, coronary artery disease, various conduction system diseases, and systolic and diastolic dysfunction of the myocardium, cardiac arrhythmias (especially atrial fibrillation), and congestive heart failure. Although these diseases generally develop in response to chronically elevated BP, marked and acute elevation of BP can lead to accentuation of an underlying predisposition to any of the symptoms traditionally associated with chronic hypertension. Management of prehypertension and hypertension is directed at the underlying cause, exacerbating factors, and the magnitude of the blood pressure abnormality. Healthy behavioral changes are a primary management tool for treating hypertension, and more particularly prehypertension and for addressing other cardiovascular risk factors, such as obesity. Pharmacological management is reserved for patients with hypertension who do not respond to behavioral changes, have additional cardiovascular risk factors or diabetes, are symptomatic or have developed target organ damage. Correspondence to: Manal Fuad Elshamaa, Pediatrics Department &Echocardiography Clinic, National Research Centre, Cairo, Egypt, E-mail: manal_elshmaa@hotmail.com","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67444707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Smoking prevalence has been declining in recent years due to utilizing a multi-faceted approach including; policy implementation, ongoing education and behavioural interventions. It has been suggested that the tobacco control approach can be applied to obesity management but the uptake has been minimal. This article examines plausible reasons as to why the suggested strategies from tobacco control have not yet taken effect for obesity management specifically aiming to increase physical activity and nutrition. Utilizing tobacco control strategies to increase physical activity and healthy dietary habits to prevent obesity is not a novel idea, however unlike tobacco prevalence we have not seen a decline in rates of obesity. The purpose of this short communication is to highlight potential reasons as to why the lessons learned from tobacco control have not seen the same success on obesity prevalence specifically in North America.
{"title":"Taking tobacco control for a lap and lunch: Lessons learned from tobacco control initiatives and the impact on the uptake of obesity management strategies","authors":"Taniya S. Nagpal, M. Fagan, H. Prapavessis","doi":"10.15761/CCRR.1000386","DOIUrl":"https://doi.org/10.15761/CCRR.1000386","url":null,"abstract":"Smoking prevalence has been declining in recent years due to utilizing a multi-faceted approach including; policy implementation, ongoing education and behavioural interventions. It has been suggested that the tobacco control approach can be applied to obesity management but the uptake has been minimal. This article examines plausible reasons as to why the suggested strategies from tobacco control have not yet taken effect for obesity management specifically aiming to increase physical activity and nutrition. Utilizing tobacco control strategies to increase physical activity and healthy dietary habits to prevent obesity is not a novel idea, however unlike tobacco prevalence we have not seen a decline in rates of obesity. The purpose of this short communication is to highlight potential reasons as to why the lessons learned from tobacco control have not seen the same success on obesity prevalence specifically in North America.","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67444960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Migraine is one of the commonest neurological disorder encountered by physicians. It affects around 20% of the females and 12% males of the normal population. It is a genetically determined, neurovascular disorder having complex pathophysiology [1]. Cerebral venous thrombosis is a rare type of stroke, which affects 0.5-1% of all types of strokes .Cerebral venous thrombosis presents with varied neurological manifestations, which include headache, seizures, altered sensorium, focal neurological deficits and intracranial hypertension. There are various infective and non infective conditions associated with cerebral venous thrombosis [2].
{"title":"Cerebral venous thrombosis associated with Migraine","authors":"R. Verma, Sagarika Mahapatro, A. More","doi":"10.15761/CCRR.1000399","DOIUrl":"https://doi.org/10.15761/CCRR.1000399","url":null,"abstract":"Migraine is one of the commonest neurological disorder encountered by physicians. It affects around 20% of the females and 12% males of the normal population. It is a genetically determined, neurovascular disorder having complex pathophysiology [1]. Cerebral venous thrombosis is a rare type of stroke, which affects 0.5-1% of all types of strokes .Cerebral venous thrombosis presents with varied neurological manifestations, which include headache, seizures, altered sensorium, focal neurological deficits and intracranial hypertension. There are various infective and non infective conditions associated with cerebral venous thrombosis [2].","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67446510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Molybdenum cofactor deficiency is a rare condition characterized by brain dysfunction (encephalopathy) that worsens over time. Babies with this condition appear normal at birth, but within a week they have difficulty feeding and develop seizures that do not improve with treatment (intractable seizures). Brain abnormalities, including deterioration (atrophy) of brain tissue, lead to severe developmental delay; affected individuals usually do not learn to sit unassisted or to speak. A small percentage of affected individuals have an exaggerated startle reaction (hyperekplexia) to unexpected stimuli such as loud noises. Other features of molybdenum cofactor deficiency can include a small head size (microcephaly) and facial features that are described as "coarse."
{"title":"Molybdenum Cofactor Deficiency","authors":"W. Nyhan","doi":"10.15761/CCRR.1000404","DOIUrl":"https://doi.org/10.15761/CCRR.1000404","url":null,"abstract":"Molybdenum cofactor deficiency is a rare condition characterized by brain dysfunction (encephalopathy) that worsens over time. Babies with this condition appear normal at birth, but within a week they have difficulty feeding and develop seizures that do not improve with treatment (intractable seizures). Brain abnormalities, including deterioration (atrophy) of brain tissue, lead to severe developmental delay; affected individuals usually do not learn to sit unassisted or to speak. A small percentage of affected individuals have an exaggerated startle reaction (hyperekplexia) to unexpected stimuli such as loud noises. Other features of molybdenum cofactor deficiency can include a small head size (microcephaly) and facial features that are described as \"coarse.\"","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67446532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Elfadaly, Nelish S Ardeshna, O. Ekwenna, J. Ortiz
A 68-year-old male presented to the emergency department with severe epigastric pain six months post living donor renal transplant from his daughter-in-law. The patient had an uncomplicated transplant course and was in his usual state of health until the onset of fatigue and constant abdominal pain one week prior. He also reported weight loss, decreased appetite, and night sweats. Past medical history included hypertension, diabetes type II, basal cell carcinoma, and coronary artery bypass surgery. The physical exam was unremarkable except for jaundice and pallor. An abdominal CT scan, colonoscopy, and esophagogastroduodenoscopy were performed several days earlier at a different facility and did not show acute pathology. He was admitted for further workup due to the severity of the abdominal pain. Abstract
{"title":"Metastatic Clear Cell Renal Cell Carcinoma with an Unknown Primary in a Living Donor Kidney Transplant Recipient","authors":"Ahmed Elfadaly, Nelish S Ardeshna, O. Ekwenna, J. Ortiz","doi":"10.15761/CCRR.1000415","DOIUrl":"https://doi.org/10.15761/CCRR.1000415","url":null,"abstract":"A 68-year-old male presented to the emergency department with severe epigastric pain six months post living donor renal transplant from his daughter-in-law. The patient had an uncomplicated transplant course and was in his usual state of health until the onset of fatigue and constant abdominal pain one week prior. He also reported weight loss, decreased appetite, and night sweats. Past medical history included hypertension, diabetes type II, basal cell carcinoma, and coronary artery bypass surgery. The physical exam was unremarkable except for jaundice and pallor. An abdominal CT scan, colonoscopy, and esophagogastroduodenoscopy were performed several days earlier at a different facility and did not show acute pathology. He was admitted for further workup due to the severity of the abdominal pain. Abstract","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67447009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Onset of labor was spontaneous as well the membrane rupture with appearance of large amount of clear amniotic fluid. Fetal heart tones remained strong and regular until the delivery that occurred after two hours from the onset of labor and no signs of fetal distress were recorded. The fetal head engaged in the left occiput transverse position and afterwards it rotated easily to right occiput anterior position until the cervix was fully dilatated. One umbilical cord knot was around the fetal neck, however the fetus was delivered with no traction. During the expulsion phase of the labor a complete spontaneous severance of all the three umbilical vessels occurred at fetus side while umbilical cord was regularly attached to the placenta side.
{"title":"Rupture of umbilical cord at birth: an unusual case of acute neonatal haemorrhage","authors":"L. Petris, M. Sabatini, E. Ruffini","doi":"10.15761/ccrr.1000433","DOIUrl":"https://doi.org/10.15761/ccrr.1000433","url":null,"abstract":"Onset of labor was spontaneous as well the membrane rupture with appearance of large amount of clear amniotic fluid. Fetal heart tones remained strong and regular until the delivery that occurred after two hours from the onset of labor and no signs of fetal distress were recorded. The fetal head engaged in the left occiput transverse position and afterwards it rotated easily to right occiput anterior position until the cervix was fully dilatated. One umbilical cord knot was around the fetal neck, however the fetus was delivered with no traction. During the expulsion phase of the labor a complete spontaneous severance of all the three umbilical vessels occurred at fetus side while umbilical cord was regularly attached to the placenta side.","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67447511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Abdalla, Ahmad O Ahmad, Husam Altahan, Ibrahim A AlOraini, Abdulrahman Altahan
Neuropsychiatric systemic lupus erythematosis (NPSLE) is one of the main diagnostic criteria of systemic lupus erythematosis (SLE), occurring in 25% 75% of affected patients [1,2]. Chorea is recognized as one of the clinical manifestations of NPSLE especially in children, however it is very rare to occur as the first presenting feature of SLE [3]. In this report we describe a teenage girl who presented acutely with generalized chorea and was found later on to have SLE. Her case will be described in detail and the topic of NPSLE will be reviewed.
{"title":"Systemic lupus erythematosus presenting as generalized chorea: case report and review of literature","authors":"M. Abdalla, Ahmad O Ahmad, Husam Altahan, Ibrahim A AlOraini, Abdulrahman Altahan","doi":"10.15761/CCRR.1000391","DOIUrl":"https://doi.org/10.15761/CCRR.1000391","url":null,"abstract":"Neuropsychiatric systemic lupus erythematosis (NPSLE) is one of the main diagnostic criteria of systemic lupus erythematosis (SLE), occurring in 25% 75% of affected patients [1,2]. Chorea is recognized as one of the clinical manifestations of NPSLE especially in children, however it is very rare to occur as the first presenting feature of SLE [3]. In this report we describe a teenage girl who presented acutely with generalized chorea and was found later on to have SLE. Her case will be described in detail and the topic of NPSLE will be reviewed.","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"211 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67444849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Received: June 18, 2018; Accepted: June 24, 2018; Published: June 30, 2018 A 42-year old apparently healthy male presented with the complaints of a swelling and bleeding. History revealed no significant findings except that he was a smoker for 10-years. On examination, a small mucosal elevation of 1 x 1 cm in size with small pin point openings was observed in the right side of the palate close to the midline raphe. Under the clinical impression of necrotizing sialometaplasia, the lesion was excised for histopathological evaluation. The microscopy showed keratinized surface epithelium with pseudoepitheliomatous hyperplasia and dilated endothelial cell lined vascular spaces with adjacent mucous minor salivary glands. High power examination of the vascular spaces revealed projection of the vessel wall into the lumen and covered by endothelial cells with admixed fibrin mesh. The vascular pathology also involved the adjacent minor salivary gland lobules (Figure 1). The differential diagnosis includes hemangioma and necrotizing sialometaplasia. The capillary size dilated blood vessel would indicate hemangioma but the tufted papillary projections are not typical of it. The presence of pseudoepitheliomatous hyperplasia may be confused with the more common necrotizing sialometaplasia, but the latter also show acinar degeneration with preservation of the lobular architecture, squamous metaplasia and inflammation. The present microscopic features are consistent with intravascular papillary endothelial hyperplasia.
{"title":"Intravascular papillary endothelial hyperplasia with pseudoepitheliomatous hyperpasia","authors":"I. Ponniah","doi":"10.15761/CCRR.1000424","DOIUrl":"https://doi.org/10.15761/CCRR.1000424","url":null,"abstract":"Received: June 18, 2018; Accepted: June 24, 2018; Published: June 30, 2018 A 42-year old apparently healthy male presented with the complaints of a swelling and bleeding. History revealed no significant findings except that he was a smoker for 10-years. On examination, a small mucosal elevation of 1 x 1 cm in size with small pin point openings was observed in the right side of the palate close to the midline raphe. Under the clinical impression of necrotizing sialometaplasia, the lesion was excised for histopathological evaluation. The microscopy showed keratinized surface epithelium with pseudoepitheliomatous hyperplasia and dilated endothelial cell lined vascular spaces with adjacent mucous minor salivary glands. High power examination of the vascular spaces revealed projection of the vessel wall into the lumen and covered by endothelial cells with admixed fibrin mesh. The vascular pathology also involved the adjacent minor salivary gland lobules (Figure 1). The differential diagnosis includes hemangioma and necrotizing sialometaplasia. The capillary size dilated blood vessel would indicate hemangioma but the tufted papillary projections are not typical of it. The presence of pseudoepitheliomatous hyperplasia may be confused with the more common necrotizing sialometaplasia, but the latter also show acinar degeneration with preservation of the lobular architecture, squamous metaplasia and inflammation. The present microscopic features are consistent with intravascular papillary endothelial hyperplasia.","PeriodicalId":72607,"journal":{"name":"Clinical case reports and reviews","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67447351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：