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Good Drug, Bad Practice: Tackling the Ivermectin Fiasco 好药,坏做法:应对伊维菌素惨败
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.17
A. Niraula, Vasudha Sundaravaradan, Rebecca M. Price
Throughout history, biomedical advancements have alleviated suffering worldwide and significantly advanced human well-being. As researchers and educators, we are well-familiar with the painstakingly slow and meticulous process of science, some of which culminates in a life-saving therapy or a revolutionary cure. Ivermectin, the drug hailed for treating river blindness and filariasis across the globe, is one such feat of scientific discovery. However, Ivermectin has lately been falsely purported to treat COVID-19, endangering the lives of millions who have taken to self-medication. Worse even, the drug has been weaponized to undermine vaccines, which are our only solution out of this pandemic. The popularity of Ivermectin among large swaths of people is a somber lesson on the need to bridge the gap between science and the public, and to incorporate science education into our curricula. In this lesson, students learn how Ivermectin treats parasitic illnesses but does not treat COVID-19, how politically-motivated scientific misinformation has jeopardized people’s lives, and how lack of proper oversight of scientific papers has fueled the Ivermectin crisis. Through active learning techniques to foster quantitative skills and critical analysis, student-driven activities and discussions, and readings and reflections, this lesson aims to empower students to apply science literacy and education in their daily lives.
纵观历史,生物医学的进步减轻了全世界的痛苦,显著提高了人类的福祉。作为研究人员和教育工作者,我们非常熟悉缓慢而细致的科学过程,其中一些过程最终会带来挽救生命的疗法或革命性的治愈方法。伊维菌素(Ivermectin),一种因治疗河盲症和丝虫病而享誉全球的药物,就是这样一项科学发现的壮举。然而,伊维菌素最近被错误地声称可以治疗COVID-19,危及数百万自行服用药物的人的生命。更糟糕的是,这种药物已经被武器化,以破坏疫苗,这是我们摆脱这场大流行的唯一解决方案。伊维菌素在大量人群中的流行是一个沉重的教训,说明有必要弥合科学与公众之间的差距,并将科学教育纳入我们的课程。在这节课中,学生们了解了伊维菌素如何治疗寄生虫病,但却不能治疗COVID-19,政治动机的科学错误信息如何危及人们的生命,以及缺乏对科学论文的适当监督如何加剧了伊维菌素危机。通过积极的学习技巧来培养定量技能和批判性分析,学生主导的活动和讨论,以及阅读和思考,本课程旨在使学生能够在日常生活中应用科学素养和教育。
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引用次数: 0
Facilitating Scientific Literacy Through Writing: A Write-to-Learn Assignment for Large Introductory Undergraduate Biology Courses 通过写作促进科学素养:大型本科生物学入门课程的“从写到学”作业
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.26
Ayuni W. Ratnayake, Cindy Naw, Karolyn R. Keir, Aarthi Ashok
Write-to-learn (WTL) assignments have been used in a variety of disciplines to encourage conceptual learning and critical thinking in undergraduate education. These assignments focus on facilitating rather than assessing learning. Conversely, write-to-communicate (WTC) assignments ( e.g., lab reports and exams), often with the goal of assessing learning, are more commonly employed in foundation STEM courses. We developed a WTL assignment that focuses on promoting curiosity driven learning, critical thinking, and metacognition; skills that promote students’ scientific literacy through writing. We integrated theoretical frameworks for scientific literacy, that include the sub-constructs of third space , authenticity , and multiple discourse as well as science as a human endeavour , and metacognition and self-direction (1, 2) to develop this 3-part WTL assignment. In this assignment, students first select a topic of interest and write freely on their current understanding of the topic (Part 1). They then develop a research question based on their writing and seek answers to their question from published literature (Part 2). Finally, they reflect on their overall experience with the WTL process and propose further avenues of investigation for their research topic (Part 3). Student feedback suggests that they enjoyed the WTL process and their overall satisfaction with the structure of the assignment was high. As we continue to evolve the assignment based on student feedback, we are gratified that students reported high self-efficacy with regard to future writing as a result of participating in this assignment. We recommend use of this type of WTL assignment in large, introductory STEM courses, so as to facilitate rather than simply assess students’ learning.
在本科教育中,写作-学习(WTL)作业已被用于各种学科,以鼓励概念学习和批判性思维。这些作业侧重于促进学习,而不是评估学习。相反,写作交流(WTC)作业(例如,实验报告和考试)通常以评估学习为目标,更常用于基础STEM课程。我们开发了一个WTL作业,重点是促进好奇心驱动的学习,批判性思维和元认知;通过写作提高学生科学素养的技能。我们整合了科学素养的理论框架,包括第三空间、真实性、多元话语、科学作为人类努力的子结构、元认知和自我指导(1,2)来开发这个由三部分组成的WTL作业。在这项作业中,学生首先选择一个感兴趣的主题,并自由地撰写他们目前对该主题的理解(第1部分)。然后,他们根据自己的写作提出一个研究问题,并从发表的文献中寻求问题的答案(第2部分)。最后,他们反思了他们在WTL过程中的整体体验,并为他们的研究课题提出了进一步的调查途径(第3部分)。学生的反馈表明,他们喜欢WTL过程,他们对作业结构的总体满意度很高。当我们根据学生的反馈继续改进作业时,我们很高兴地看到,学生们在参与这项作业后,对未来的写作表现出了很高的自我效能。我们建议在大型STEM入门课程中使用这种类型的WTL作业,以促进而不是简单地评估学生的学习。
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引用次数: 0
Learning R for Biologists: A Mini Course Grab-Bag for Instructors 生物学家学习R语言:讲师迷你课程包
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.12
Amanda D. Clark, L. Stevison
As biology becomes more data driven, teaching students data literacy skills has become central to biology curriculum. Despite a wealth of online resources that teach researchers how to use R, there are few that offer practical laboratory-based exercises, with teaching resources such as keys, learning objectives, and assessment materials. Here, we present a modular set of lessons and lab activities to help teach R through the platform of RStudio. Both software applications are free and open source making this curriculum highly accessible across various institutions. This curriculum was developed over several years of teaching a graduate level computational biology course. In response to the pandemic, the class was shifted to be completely online. These resources were then migrated to GitHub to make them broadly accessible to anyone wanting to learn R for the analysis of biological datasets. In the following year, these resources were used to teach the course in a flipped format, which is the lesson plan presented here. In general, students responded well to the flipped format, which used class time to conduct live coding demos and work through challenges with the instructor and teaching assistant. Overall, students were able to use these skills to practice analyzing and interpreting data, as well as producing publication quality graphics. While the modules presented range from very basic, doing simple summary statistics and plotting, to quite advanced, where R is integrated onto the command line, teachers should feel free to pick and choose which elements to incorporate into their own curriculum.
随着生物学越来越受数据驱动,教授学生数据素养技能已成为生物学课程的核心。尽管有丰富的在线资源教研究人员如何使用R,但很少有提供实用的实验室练习,以及教学资源,如关键字,学习目标和评估材料。在这里,我们提供了一套模块化的课程和实验活动,以帮助通过RStudio平台教授R。这两个软件应用程序都是免费和开源的,这使得这个课程在不同的机构中都很容易获得。这个课程是在几年教授研究生水平的计算生物学课程的基础上发展起来的。为应对新冠肺炎疫情,该课程完全改为在线授课。这些资源随后被迁移到GitHub上,使任何想要学习R来分析生物数据集的人都可以广泛地访问它们。在接下来的一年里,这些资源被用于以翻转的形式教授课程,这就是这里展示的课程计划。总的来说,学生们对翻转教学模式反应良好,这种模式利用课堂时间进行现场编码演示,并与讲师和助教一起解决挑战。总的来说,学生们能够使用这些技能来练习分析和解释数据,以及制作出版质量的图形。虽然所提供的模块范围从非常基本的(做简单的汇总统计和绘图)到相当高级的(将R集成到命令行中),但教师应该自由选择将哪些元素纳入自己的课程。
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引用次数: 0
Discovery and Invention: A Reflection on Representation in Science 发现与发明:对科学再现的反思
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.13
Fátima Sancheznieto, Lauren Lucas, C. Theisen
Despite increased awareness of the lack of equity and inclusion in the STEMM classroom, lessons on DEI topics are treated as separate to the scientific curriculum being taught. Rarely are intentional reflections and conversations on the lack of representation integrated into the lessons themselves. This lesson, titled “Discovery and Invention”, was developed to guide students through an exploration of the history of a topic—in this case, fermentation—followed by reflections and discussion on the culture of science and how it highlights certain individuals over others. Reflections allow students to explore and discuss their own scientific self-identity and sense of belonging in science. This fermentation lesson was designed to be integrated into a unit introducing students to microbial ecosystems, but it can be adapted for other topics as well, to suit the instructor’s needs
尽管越来越多的人意识到stem课堂缺乏公平和包容性,但关于DEI主题的课程被视为与正在教授的科学课程分开。很少有关于缺乏代表性的有意识的反思和对话融入到课程本身。这节课的题目是“发现与发明”,旨在引导学生探索一个主题的历史——在这个例子中是发酵——然后是对科学文化的反思和讨论,以及它如何突出某些个体而不是其他人。反思让学生探索和讨论自己的科学自我认同和科学归属感。这个发酵课被设计成一个单元,向学生介绍微生物生态系统,但它可以适应其他主题,以及,以适应教师的需要
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引用次数: 0
Population Ecology of the Northern Spotted Owl 北方斑点猫头鹰的种群生态学
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.30
S. Streich, John M. Basey
The mathematical modeling of populations utilizing field-collected demographic data is an important component of lab curricula in a variety of undergraduate biology lab courses. During the global pandemic brought about by the SARS-CoV-2 virus in 2020, we successfully converted an in-person lab on demographic population modeling to a lab that could be run remotely. We used a Google Earth Web Project to simulate a population study of the Northern Spotted Owl. In the simulation, students collected both demographic and mark-recapture data, based on surveying images of Northern Spotted Owls as they navigated four different wildlife transects. After conducting the survey, students used the data to determine population size using the mark-recapture method, derived a life table, calculated the net reproductive rate, and used the information to assess the current management plan for the population studied. Here we outline the lesson and provide materials required to duplicate the lab or to use Google Earth to create a similar simulation centered around a different species in any location around the globe.
利用野外采集的人口统计数据建立种群数学模型是各种本科生物学实验课程的重要组成部分。在2020年SARS-CoV-2病毒带来的全球大流行期间,我们成功地将一个面对面的人口模型实验室转变为一个可以远程运行的实验室。我们使用谷歌地球网络项目来模拟北斑猫头鹰的种群研究。在模拟中,学生们收集了人口统计数据和标记再捕获数据,这些数据是基于对北斑猫头鹰在四个不同的野生动物样带中导航时的调查图像。在进行调查之后,学生们利用这些数据用标记-再捕获法确定种群规模,推导出生命表,计算净繁殖率,并利用这些信息评估当前对所研究种群的管理计划。在这里,我们概述的教训,并提供所需的材料复制实验室或使用谷歌地球创建一个类似的模拟中心围绕一个不同的物种在全球任何位置。
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引用次数: 3
An Original-Design Board Game to Increase Student Comprehension of Cellular Respiration Pathways 一个原创设计的棋盘游戏,以提高学生对细胞呼吸途径的理解
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.6
Matthew B. Parks
Cellular respiration is a daunting topic for many students in introductory biology courses. Students are challenged at conceptual and factual levels, since instruction covers multiple metabolic pathways occurring across different cellular compartments, involving abstract energy and electron transfers through diverse chemical reactions. Lecture-based instruction may clearly convey details of cellular respiration to students, but the complexity of this topic suggests alternative, active learning strategies may improve student comprehension and retention. I designed an original board game as a teaching tool for cellular respiration, targeted at improving learning outcomes for advanced high school, introductory undergraduate
细胞呼吸对许多生物学入门课程的学生来说是一个令人生畏的话题。学生在概念和事实层面面临挑战,因为教学涵盖了不同细胞间发生的多种代谢途径,包括通过各种化学反应进行的抽象能量和电子转移。以讲座为基础的教学可以清楚地向学生传达细胞呼吸的细节,但这一主题的复杂性表明,另一种积极的学习策略可能会提高学生的理解和记忆。我设计了一款原创的棋盘游戏,作为细胞呼吸的教学工具,旨在提高高级高中,入门本科的学习效果
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引用次数: 0
Outside the Norm: Using Public Ecology Database Information to Teach Biostatistics 超常规:利用公共生态数据库信息进行生物统计学教学
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.38
Carl Tyce, Lara K. Goudsouzian
Biology students’ understanding of statistics is incomplete due to poor integration of these two disciplines. In some cases, students fail to learn statistics at the undergraduate level due to poor student interest and cursory teaching of concepts, highlighting a need for new and unique approaches to the teaching of statistics in the undergraduate biology curriculum. The most effective method of teaching statistics is to provide opportunities for students to apply concepts, not just learn facts. Opportunities to learn statistics also need to be prevalent throughout a student’s education to reinforce learning. The purpose of developing and implementing curriculum that integrates a topic in biology with an emphasis on statistical analysis was to improve students’ quantitative thinking skills. Our lesson focuses on the change in the richness of native species for a specified area with the aid of iNaturalist and the capacity for analysis afforded by Google Sheets. We emphasized the skills of data entry, storage, organization, curation and analysis. Students then had to report their findings, as well as discuss biases and other confounding factors. Pre-and post-lesson assessment revealed students’ quantitative thinking skills, as measured by a paired-samples t test, improved. At the end of the lesson, students had an increased understanding of basic statistical concepts, such as bias in research and making data-based claims, within the framework of biology.
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引用次数: 0
Evaluating Representation in Science Through a Peer-Reviewed Research Study 通过同行评议研究评估科学中的代表性
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.41
Cissy J. Ballen, Abby E. Beatty, Enya Granados
The demographic representation of scientists featured in biology curricular materials do not match that of the undergraduate biology student population or of the U.S. population. In this lesson, we promote awareness of inequity in science through an exercise that encourages students to think about who is depicted as scientists in science curricular materials—specifically, biology textbooks. After a brief lecture on the scientific method, students read an excerpt from the introduction of a peer-reviewed publication that provides background information on the importance of representation in science. Next, students collect data from their own biology textbook about the representation of scientists who possess different identities and make a table depicting their results. Then, students fill in predictive graphs about demographic representation over time with respect to scientist identities including perceived gender and race/ethnicity. Students compare their predictions with the results from the peer-reviewed article and discuss the implications of the results. Finally, students apply their new knowledge by designing an experiment that would examine representation of an alternative scientist identity, such as age. Students conclude by answering questions that gauge their knowledge of the scientific method. This activity uses a peer-reviewed publication as well as authentic data generated by the student to increase ideological awareness and teach societal influences on the process of science. Primary Image: Many stacked textbooks. Creative Commons Attribution-Share Alike 4.0 Downloaded from Wikimedia Commons on May 30, 2023 by authors.
生物学课程材料中科学家的人口统计学代表与生物学本科生或美国人口的人口统计学代表不匹配。在这节课中,我们通过一个练习来提高学生对科学不平等的认识,这个练习鼓励学生思考在科学课程材料中,特别是在生物教科书中,谁被描绘成科学家。在关于科学方法的简短讲座之后,学生们阅读了一篇摘录自同行评审出版物的介绍,该出版物提供了代表性在科学中的重要性的背景信息。接下来,学生们从他们自己的生物学教科书中收集关于具有不同身份的科学家的代表的数据,并制作一个表格来描述他们的结果。然后,学生们填写关于科学家身份的预测图表,包括感知到的性别和种族/民族。学生们将他们的预测与同行评议文章的结果进行比较,并讨论结果的含义。最后,学生们通过设计一个实验来应用他们的新知识,这个实验将检验另一种科学家身份的代表,比如年龄。学生通过回答问题来衡量他们对科学方法的了解程度。该活动使用同行评审的出版物以及学生生成的真实数据来提高思想意识并教授社会对科学过程的影响。主要形象:许多堆叠的教科书。2023年5月30日由作者从维基共享资源下载。
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引用次数: 0
The Developmental Origins of Mythology: A Pandemic-Inspired Innovative Developmental Biology Laboratory Exercise 神话的发展起源:大流行启发的创新发育生物学实验室练习
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.21
Laura A Dyer
From an experiential, hands-on perspective, the Developmental Biology Laboratory is easily amenable to a wide range of undergraduate-friendly experiments. Thus, pivoting to a virtual laboratory during the COVID-19 pandemic required significant reconfiguring to capture the essence of student-driven experiments. The innovative laboratory activity described here was inspired by the nuggets of truth contained within many of the mythological origin stories. Students were asked to propose a logical developmental process that could lead to a specific mythological creature. In this article, the mythology-based developmental biology activity is described, including its inspiration, instructions and support for the students, and sample work.
从经验,动手的角度来看,发育生物学实验室很容易适应广泛的本科生友好的实验。因此,在COVID-19大流行期间转向虚拟实验室需要进行重大重新配置,以捕捉学生驱动实验的本质。这里描述的创新实验室活动的灵感来自于许多神话起源故事中包含的真理。学生们被要求提出一个可能导致特定神话生物的逻辑发展过程。本文介绍了以神话为基础的发育生物学活动,包括对学生的启发、指导和支持,以及样本作业。
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引用次数: 0
Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes 中心法则、字典和函数:使用编程概念模拟生物过程
Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.24
Jyothi Kumar, Fabio Gomez-Cano, S. W. Hunt, Serena G Lotreck, Davis T Mathieu, McKena L. Wilson, T. Long
Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills to analyze biological data while understanding the underlying biological concepts. The Integrated training Model in Plant And ComputaTional Sciences (IMPACTS) is an interdisciplinary training program that trains doctoral students to employ computational and data science approaches to address grand challenges in plant biology. The first course in the curriculum, Foundations in Computational Plant Science , focuses on fundamental knowledge in computational and plant science through group learning and peer instruction while using real-world data. The lesson plan described here was developed by the 2019 cohort of IMPACTS trainees (authoring cohort) as part of a subsequent course on STEM teaching and learning. The authoring cohort collaborated to identify a gap in the Foundations curriculum and applied their learning about evidence-based instructional design to develop and subsequently teach the lesson in the next iteration of the course (2020). The lesson plan’s goal was to develop students’ abilities to apply dictionaries and functions as core tools in computational science to answer biological questions. The 2020 cohort that completed the lesson reported confidence in being able to effectively apply dictionaries and functions and provided feedback about modifications to improve lesson efficacy. This feedback was incorporated in the iterative version of this lesson. This lesson is designed to help bridge the gap between computer scientists and biologists by teaching them interdisciplinary concepts using real-world data.
下一代测序、蛋白质组学和高通量表型等技术已经改变了我们研究生物学的方式。在理解潜在的生物学概念的同时,仍然需要具有计算技能的科学家来分析生物学数据。植物与计算科学综合培训模式(impact)是一个跨学科的培训项目,旨在培养博士生运用计算和数据科学方法来解决植物生物学中的重大挑战。课程的第一门课程,计算植物科学基础,通过小组学习和同伴指导,使用真实世界的数据,重点介绍计算和植物科学的基础知识。这里描述的课程计划是由2019年的impact学员(编写组)制定的,作为后续STEM教学和学习课程的一部分。作者团队合作确定了基础课程中的差距,并将他们在基于证据的教学设计方面的学习应用于开发并随后在课程的下一次迭代(2020年)中教授课程。该课程计划的目标是培养学生运用字典和函数作为计算科学核心工具来回答生物学问题的能力。2020年完成课程的学生报告说,他们有信心能够有效地应用字典和函数,并提供有关修改的反馈,以提高课程效果。这个反馈被整合到本课的迭代版本中。本课程旨在通过使用真实世界的数据向计算机科学家和生物学家教授跨学科的概念,帮助他们弥合差距。
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