The goal of this study is to analyze associations between COVID-19 transmission and meteorological indicators in cities of the Black Sea region of Turkey, located specifically in the dampest area, with excess rainfall and recurring fog. In particular, the working hypothesis is that the widespread transmission of new coronavirus SARS-CoV-2 (leading to the airborne disease COVID-19) in cities can be explained by specific weather conditions, namely high levels of air humidity. Statistical evidence here does not seem, in general, to support the hypothesis that the accelerated transmission of COVID-19 in the studied cities can be explained by high levels of humidity because different meteorological, environmental, demographic, and socioeconomic factors also plays a critical role in the disease transmission dynamics of the investigated region. The main implications of our findings here are that the demographic structure of the population, climate indicators, organization of the health system, and environmental factors (e.g., air pollution, etc.) should be considered through a systemic approach when designing effective national and regional pandemic plans directed to implement health policies for facing new variants of COVID-19 and/or new airborne diseases, in order to reduce their negative effects on health, social and economic systems.
{"title":"Transmission of COVID-19 in Cities with Weather Conditions of High Air Humidity: Lessons Learned from Turkish Black Sea Region to Face Next Pandemic Crisis","authors":"Aytac Perihan Akan, Mario Coccia","doi":"10.3390/covid3110113","DOIUrl":"https://doi.org/10.3390/covid3110113","url":null,"abstract":"The goal of this study is to analyze associations between COVID-19 transmission and meteorological indicators in cities of the Black Sea region of Turkey, located specifically in the dampest area, with excess rainfall and recurring fog. In particular, the working hypothesis is that the widespread transmission of new coronavirus SARS-CoV-2 (leading to the airborne disease COVID-19) in cities can be explained by specific weather conditions, namely high levels of air humidity. Statistical evidence here does not seem, in general, to support the hypothesis that the accelerated transmission of COVID-19 in the studied cities can be explained by high levels of humidity because different meteorological, environmental, demographic, and socioeconomic factors also plays a critical role in the disease transmission dynamics of the investigated region. The main implications of our findings here are that the demographic structure of the population, climate indicators, organization of the health system, and environmental factors (e.g., air pollution, etc.) should be considered through a systemic approach when designing effective national and regional pandemic plans directed to implement health policies for facing new variants of COVID-19 and/or new airborne diseases, in order to reduce their negative effects on health, social and economic systems.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"37 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesús Enrique Patiño Escarcina, Felipe de Jesus Souza, Ana Keila Carvalho Vieira Da Silva, Keile Kemyly Assis Da Silva, Ruan Barbosa Souza, Saulo Reis Nery Santos, Eduardo M. Netto
The emergence and rapid spread of the SARS-CoV-2 Gamma variant in Brazil have raised concerns about SARS-CoV-2 vaccines’ neutralizing capacity and viral load impact. Our study aimed to assess the influence of the CoviShield and CoronaVac vaccines on the Ct-N2 value in the healthcare organization’s staff who experienced primary SARS-CoV-2 infection. We examined sixty-three COVID-19 cases reported in the first half of 2021 and identified similar clinical and laboratory characteristics among individuals, regardless of the vaccine they received. Surprisingly, our observations revealed that both CoviShield and CoronaVac vaccines had no impact on viral load or the development and severity of symptoms. These findings suggest a potential reduction in neutralizing response and indicate the need to consider the incorporation of other SARS-CoV-2 vaccines and maintain additional containment measures against SARS-CoV-2, as they remain imperative despite vaccination efforts.
{"title":"Evaluation of CoronaVac and CoviShield Vaccines on SARS-CoV-2 Infection in Healthcare Workers in Salvador, Brazil","authors":"Jesús Enrique Patiño Escarcina, Felipe de Jesus Souza, Ana Keila Carvalho Vieira Da Silva, Keile Kemyly Assis Da Silva, Ruan Barbosa Souza, Saulo Reis Nery Santos, Eduardo M. Netto","doi":"10.3390/covid3110112","DOIUrl":"https://doi.org/10.3390/covid3110112","url":null,"abstract":"The emergence and rapid spread of the SARS-CoV-2 Gamma variant in Brazil have raised concerns about SARS-CoV-2 vaccines’ neutralizing capacity and viral load impact. Our study aimed to assess the influence of the CoviShield and CoronaVac vaccines on the Ct-N2 value in the healthcare organization’s staff who experienced primary SARS-CoV-2 infection. We examined sixty-three COVID-19 cases reported in the first half of 2021 and identified similar clinical and laboratory characteristics among individuals, regardless of the vaccine they received. Surprisingly, our observations revealed that both CoviShield and CoronaVac vaccines had no impact on viral load or the development and severity of symptoms. These findings suggest a potential reduction in neutralizing response and indicate the need to consider the incorporation of other SARS-CoV-2 vaccines and maintain additional containment measures against SARS-CoV-2, as they remain imperative despite vaccination efforts.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"212 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136317410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linying Dong, Alexandra Katsiris, Mariah Lecompte, Cassandra Skrotzki, Lixia Yang
The ability to adaptively cope with the challenges of stressful events such as the COVID-19 pandemic is crucial for healthy aging. One effective coping strategy is social coping in which social networks are tapped for support. However, our review of the current literature on older adults’ coping abilities reveals two shortcomings: (1) a lack of consideration of a specific context and (2) an inadequate amount of attention paid to the different types of social networks in the cognitive appraisal process. As coping is a process in which older adults undergo the cognitive appraisal process to identify appropriate coping strategies, the shortcomings result in an incomplete understanding of older adults’ coping efforts and impair the development of effective community and intervention programs to improve older adults’ well-being. To fill this gap, drawing on the Transactional Model of Stress and Coping and the Social Capital Theory, we conducted 22 interviews with older adults who experienced lockdown measures during COVID-19. Our in-depth qualitative analysis shows the different roles played by bonding and bridging social capital in the cognitive appraisal process and illustrates the influence of a specific context on cognitive appraisals and subsequent coping efforts. Our findings provide significant contributions to theories regarding coping and social capital, as well as practices and policies for improving the well-being of older adults.
{"title":"A Qualitative Analysis of Older Adults’ Cognitive Appraisal in Coping during the COVID-19 Pandemic: The Role of Social Capital","authors":"Linying Dong, Alexandra Katsiris, Mariah Lecompte, Cassandra Skrotzki, Lixia Yang","doi":"10.3390/covid3100111","DOIUrl":"https://doi.org/10.3390/covid3100111","url":null,"abstract":"The ability to adaptively cope with the challenges of stressful events such as the COVID-19 pandemic is crucial for healthy aging. One effective coping strategy is social coping in which social networks are tapped for support. However, our review of the current literature on older adults’ coping abilities reveals two shortcomings: (1) a lack of consideration of a specific context and (2) an inadequate amount of attention paid to the different types of social networks in the cognitive appraisal process. As coping is a process in which older adults undergo the cognitive appraisal process to identify appropriate coping strategies, the shortcomings result in an incomplete understanding of older adults’ coping efforts and impair the development of effective community and intervention programs to improve older adults’ well-being. To fill this gap, drawing on the Transactional Model of Stress and Coping and the Social Capital Theory, we conducted 22 interviews with older adults who experienced lockdown measures during COVID-19. Our in-depth qualitative analysis shows the different roles played by bonding and bridging social capital in the cognitive appraisal process and illustrates the influence of a specific context on cognitive appraisals and subsequent coping efforts. Our findings provide significant contributions to theories regarding coping and social capital, as well as practices and policies for improving the well-being of older adults.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Izza Zaidi, Ashly E. Jordan, Lauren Jessell, Leonardo Dominguez Gomez, Alex Harocopos, Michelle Nolan
Housing conditions can increase health risks for people who use opioids (PWUO). Little research documents the influence of housing on PWUO’s ability to practice disease prevention methods. This study examines associations between housing status of PWUO in NYC and their ability to practice COVID-19 prevention recommendations during the initial wave of the pandemic. Participants were recruited via convenience sampling and administered a survey. Eligibility required age ≥18 years, using opioids ≥3times in the prior 30 days, and accessing a health-related service in the prior year. Descriptive and bivariate statistics assessed relationships between housing and the ability to practice social distancing, access soap and running water or hand sanitizer (soap), and access face masks. Multivariable Poisson regression was used to examine relationships between housing and the potential to practice COVID-19 prevention recommendations. The 329 participants were grouped into stable housing (34.3%), unstable/shelter housing (31.9%), and street homeless (33.7%) categories. Street homeless PWUO were significantly less likely to have access to soap and face masks than those stably housed. There were no significant differences between PWUO experiencing unstable and stable housing. PWUO experiencing street homelessness may have had increased vulnerability to COVID-19. Providing low-threshold health-related resources and increasing linkages to housing opportunities could promote health of PWUO experiencing street homelessness during future emergencies.
{"title":"Housing Status and COVID-19 Prevention Recommendations among People Who Use Drugs","authors":"Izza Zaidi, Ashly E. Jordan, Lauren Jessell, Leonardo Dominguez Gomez, Alex Harocopos, Michelle Nolan","doi":"10.3390/covid3100110","DOIUrl":"https://doi.org/10.3390/covid3100110","url":null,"abstract":"Housing conditions can increase health risks for people who use opioids (PWUO). Little research documents the influence of housing on PWUO’s ability to practice disease prevention methods. This study examines associations between housing status of PWUO in NYC and their ability to practice COVID-19 prevention recommendations during the initial wave of the pandemic. Participants were recruited via convenience sampling and administered a survey. Eligibility required age ≥18 years, using opioids ≥3times in the prior 30 days, and accessing a health-related service in the prior year. Descriptive and bivariate statistics assessed relationships between housing and the ability to practice social distancing, access soap and running water or hand sanitizer (soap), and access face masks. Multivariable Poisson regression was used to examine relationships between housing and the potential to practice COVID-19 prevention recommendations. The 329 participants were grouped into stable housing (34.3%), unstable/shelter housing (31.9%), and street homeless (33.7%) categories. Street homeless PWUO were significantly less likely to have access to soap and face masks than those stably housed. There were no significant differences between PWUO experiencing unstable and stable housing. PWUO experiencing street homelessness may have had increased vulnerability to COVID-19. Providing low-threshold health-related resources and increasing linkages to housing opportunities could promote health of PWUO experiencing street homelessness during future emergencies.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"495 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William Jones Dartora, Maria Inês Schmidt, Rosane Harter Griep, Bruce B. Duncan
The COVID-19 pandemic and society’s response to it may have constrained the ability of those with diabetes to achieve a healthy lifestyle. We conducted a longitudinal study to assess the frequency and magnitude of sedentary habits, physical activity, sleep, alcohol consumption, weight, and smoking from July 2020 to February 2021 and compared these levels to those before the pandemic (2017–2019) in 1082 participants of the ELSA-Brasil study with known diabetes. Our results showed that inappropriate sleep duration was common (649, 68.9%) before the pandemic. Many (447, 31.1%) with this problem achieved an adequate sleep duration during the pandemic. Significant increases occurred in time in front of screens (1.3; 95%CI 0.66–2.11 h/day) and time sitting or reclining (1.4, 95%CI 0.8–2.3 h/day). Physical activity decreased (270, 95%CI 243–298 MET-min/wk). Alcohol consumption decreased without statistical significance (−19.6, 95%CI −51.1–11.9 g/w). In general, changes were similar between diabetics and non-diabetics, except that screen time in-creased less (−0.18, −0.35–−0.01 h/day) for those with diabetes. Sleep duration improved, but the frequency of sedentary habits increased, and physical activity decreased during the pandemic. Understanding changes brought on by the pandemic is essential to facilitate the implementation of quality health care for those with diabetes in moments of social stress.
{"title":"Changes in Lifestyle Habits in Individuals with Diabetes during the COVID-19 Pandemic: The ELSA-Brasil Cohort Study","authors":"William Jones Dartora, Maria Inês Schmidt, Rosane Harter Griep, Bruce B. Duncan","doi":"10.3390/covid3100109","DOIUrl":"https://doi.org/10.3390/covid3100109","url":null,"abstract":"The COVID-19 pandemic and society’s response to it may have constrained the ability of those with diabetes to achieve a healthy lifestyle. We conducted a longitudinal study to assess the frequency and magnitude of sedentary habits, physical activity, sleep, alcohol consumption, weight, and smoking from July 2020 to February 2021 and compared these levels to those before the pandemic (2017–2019) in 1082 participants of the ELSA-Brasil study with known diabetes. Our results showed that inappropriate sleep duration was common (649, 68.9%) before the pandemic. Many (447, 31.1%) with this problem achieved an adequate sleep duration during the pandemic. Significant increases occurred in time in front of screens (1.3; 95%CI 0.66–2.11 h/day) and time sitting or reclining (1.4, 95%CI 0.8–2.3 h/day). Physical activity decreased (270, 95%CI 243–298 MET-min/wk). Alcohol consumption decreased without statistical significance (−19.6, 95%CI −51.1–11.9 g/w). In general, changes were similar between diabetics and non-diabetics, except that screen time in-creased less (−0.18, −0.35–−0.01 h/day) for those with diabetes. Sleep duration improved, but the frequency of sedentary habits increased, and physical activity decreased during the pandemic. Understanding changes brought on by the pandemic is essential to facilitate the implementation of quality health care for those with diabetes in moments of social stress.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135969469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuseppe Lippi, Fabian Sanchis-Gomar, Camilla Mattiuzzi, Brandon M. Henry
Coronavirus Disease 2019 (COVID-19) is an infectious respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease, first identified in the Chinese city of Wuhan in November 2019, has since spread worldwide, is the latest human pandemic and has officially infected over 800 million people and has caused nearly seven million deaths to date. Although SARS-CoV-2 belongs to the large family of coronaviruses, it has some unique biological characteristics in its interplay with the human host. Therefore, this narrative review aims to provide an up-to-date overview of the structure of the virus, incubation and shedding in the human host, infectivity and biological evolution over time, as well as the main mechanisms for invading human host cells and replicating within. We also proffer that ongoing epidemiological surveillance of newly emerged variants must always be accompanied by biological studies aimed at deciphering new advantageous traits that may contribute to increasing virulence and pathogenicity, such that the most appropriate strategies for establishing a (relatively) safe coexistence with the human host can be implemented.
{"title":"SARS-CoV-2: An Update on the Biological Interplay with the Human Host","authors":"Giuseppe Lippi, Fabian Sanchis-Gomar, Camilla Mattiuzzi, Brandon M. Henry","doi":"10.3390/covid3100108","DOIUrl":"https://doi.org/10.3390/covid3100108","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) is an infectious respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease, first identified in the Chinese city of Wuhan in November 2019, has since spread worldwide, is the latest human pandemic and has officially infected over 800 million people and has caused nearly seven million deaths to date. Although SARS-CoV-2 belongs to the large family of coronaviruses, it has some unique biological characteristics in its interplay with the human host. Therefore, this narrative review aims to provide an up-to-date overview of the structure of the virus, incubation and shedding in the human host, infectivity and biological evolution over time, as well as the main mechanisms for invading human host cells and replicating within. We also proffer that ongoing epidemiological surveillance of newly emerged variants must always be accompanied by biological studies aimed at deciphering new advantageous traits that may contribute to increasing virulence and pathogenicity, such that the most appropriate strategies for establishing a (relatively) safe coexistence with the human host can be implemented.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136358389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katie Holtcamp, Molly C. Nicodemus, Tommy Phillips, David Christiansen, Brian J. Rude, Peter L. Ryan, Karen Galarneau
Substance use disorder has become an epidemic in the young adult population across the United States, and these numbers rose during the COVID-19 pandemic. Psychotherapy incorporating equine interaction has emerged to show promise in the mental health community as a complementary form of therapy for this age group and offered a viable treatment option during the pandemic due to the outdoor nature of the treatment environment. However, research concerning its use within a residential treatment program was lacking. The objective of this study was to evaluate the efficacy of psychotherapy incorporating equine interaction in a residential treatment program during the COVID-19 pandemic for developing an emotionally safe environment for learning for young adults. Participants (ages 18–25 years) were those in a substance abuse residential treatment program utilizing psychotherapy incorporating equine interaction during the COVID-19 pandemic. Participants were involved in weekly equine therapy for 2–7 weeks. Participants were divided according to length of stay at the residential facility and participation level with equine interactive activities. Assessment of emotional safety and long-term memory development was performed at the beginning and end of the treatment program. The development of memories centered around equine information that was covered during the treatment program. Semantic memory was assessed using a self-reporting knowledge exam and procedural memory was assessed using a skill evaluation. Emotional safety was determined using a self-reporting survey instrument. Paired t-tests determined significant improvement in emotional safety (p = 0.02) and semantic (p = 0.01) and procedural (p = 0.00) memory for all participants by the end of the program. The one-way analysis of variance indicated length of stay and participation level were not significant indicators of emotional safety (length of stay: p = 0.91, participation level: p = 0.98) and semantic (length of stay: p = 0.09, participation level: p = 0.60) and procedural (length of stay: p = 0.25, participation level: p = 0.09) memory development. These results suggest psychotherapy incorporating equine interaction was an efficient complementary therapeutic intervention for developing emotional safety and encouraging learning in a young-adult residential addiction treatment program during the COVID-19 pandemic.
{"title":"Psychotherapy Incorporating Equine Interaction as a Complementary Therapeutic Intervention for Young Adults in a Residential Treatment Program during the COVID-19 Pandemic","authors":"Katie Holtcamp, Molly C. Nicodemus, Tommy Phillips, David Christiansen, Brian J. Rude, Peter L. Ryan, Karen Galarneau","doi":"10.3390/covid3100107","DOIUrl":"https://doi.org/10.3390/covid3100107","url":null,"abstract":"Substance use disorder has become an epidemic in the young adult population across the United States, and these numbers rose during the COVID-19 pandemic. Psychotherapy incorporating equine interaction has emerged to show promise in the mental health community as a complementary form of therapy for this age group and offered a viable treatment option during the pandemic due to the outdoor nature of the treatment environment. However, research concerning its use within a residential treatment program was lacking. The objective of this study was to evaluate the efficacy of psychotherapy incorporating equine interaction in a residential treatment program during the COVID-19 pandemic for developing an emotionally safe environment for learning for young adults. Participants (ages 18–25 years) were those in a substance abuse residential treatment program utilizing psychotherapy incorporating equine interaction during the COVID-19 pandemic. Participants were involved in weekly equine therapy for 2–7 weeks. Participants were divided according to length of stay at the residential facility and participation level with equine interactive activities. Assessment of emotional safety and long-term memory development was performed at the beginning and end of the treatment program. The development of memories centered around equine information that was covered during the treatment program. Semantic memory was assessed using a self-reporting knowledge exam and procedural memory was assessed using a skill evaluation. Emotional safety was determined using a self-reporting survey instrument. Paired t-tests determined significant improvement in emotional safety (p = 0.02) and semantic (p = 0.01) and procedural (p = 0.00) memory for all participants by the end of the program. The one-way analysis of variance indicated length of stay and participation level were not significant indicators of emotional safety (length of stay: p = 0.91, participation level: p = 0.98) and semantic (length of stay: p = 0.09, participation level: p = 0.60) and procedural (length of stay: p = 0.25, participation level: p = 0.09) memory development. These results suggest psychotherapy incorporating equine interaction was an efficient complementary therapeutic intervention for developing emotional safety and encouraging learning in a young-adult residential addiction treatment program during the COVID-19 pandemic.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135548351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saira Sarwar, Rebecca Aicheler, Lee Butcher, Katie Rees, Stephen Potter, Richard Rowlands, Richard Webb
Given the variability in inflammatory responses to SARS-CoV-2 infection observed within human populations, we aimed to develop an in vitro model system (based on monocyte-macrophages, a key relevant cell type) that could yield insights regarding the impact of rs2228145, a clinically relevant polymorphism within the coding region of a key inflammatory gene in the body’s response to SARS-CoV-2 infection: the interleukin-6 receptor (IL-6R) gene. Three monocyte-macrophage cell-lines (U937, THP-1, MM6) were shown to exhibit AA, AC and CC rs2228145 genotypes, respectively, and to exhibit an MM6 > THP-1 > U937 pattern regarding basal levels of soluble IL-6R (sIL-6R) release. Similar MM6 > THP-1 > U937 patterns were seen regarding the extents to which (i) circulating levels of the IL-6/sIL-6R ‘active complex’ increased and (ii) phosphorylation of the downstream transcription-factor STAT3 occurred, following treatment with SARS-CoV-2 spike protein (SP). Moreover, a blocking antibody for the ACE-2 entry receptor for SARS-CoV-2 suppressed effects (i) and (ii), suggesting that interaction between SP and ACE-2 is the initial event that triggers IL-6/IL-6R signalling in our system. Production of IL-8 occurred to greater extents in A549 lung epithelial cells treated with tissue-culture supernatants from SP-treated MM6 cultures than SP-treated THP-1 or U937 cultures. Our data indicate that the rs2228145 genotype significantly impacts upon SP-associated IL-6/sIL-6R signalling in vitro, suggesting that it may influence in vivo risk of developing severe COVID-19 and/or long-COVID symptoms following infection by SARS-CoV-2. Thus, the rs2228145 genotype may have potential as a biomarker that differentiates between patients at risk of developing severe and/or prolonged symptoms following infection by SARS-CoV-2 and those who are at less risk.
{"title":"The rs2228145 Variant of the Interleukin-6 Receptor (IL-6R) Gene Impacts on In Vitro Cellular Responses to SARS-CoV-2 VOC B1.1.7 Recombinant Spike Protein","authors":"Saira Sarwar, Rebecca Aicheler, Lee Butcher, Katie Rees, Stephen Potter, Richard Rowlands, Richard Webb","doi":"10.3390/covid3100106","DOIUrl":"https://doi.org/10.3390/covid3100106","url":null,"abstract":"Given the variability in inflammatory responses to SARS-CoV-2 infection observed within human populations, we aimed to develop an in vitro model system (based on monocyte-macrophages, a key relevant cell type) that could yield insights regarding the impact of rs2228145, a clinically relevant polymorphism within the coding region of a key inflammatory gene in the body’s response to SARS-CoV-2 infection: the interleukin-6 receptor (IL-6R) gene. Three monocyte-macrophage cell-lines (U937, THP-1, MM6) were shown to exhibit AA, AC and CC rs2228145 genotypes, respectively, and to exhibit an MM6 > THP-1 > U937 pattern regarding basal levels of soluble IL-6R (sIL-6R) release. Similar MM6 > THP-1 > U937 patterns were seen regarding the extents to which (i) circulating levels of the IL-6/sIL-6R ‘active complex’ increased and (ii) phosphorylation of the downstream transcription-factor STAT3 occurred, following treatment with SARS-CoV-2 spike protein (SP). Moreover, a blocking antibody for the ACE-2 entry receptor for SARS-CoV-2 suppressed effects (i) and (ii), suggesting that interaction between SP and ACE-2 is the initial event that triggers IL-6/IL-6R signalling in our system. Production of IL-8 occurred to greater extents in A549 lung epithelial cells treated with tissue-culture supernatants from SP-treated MM6 cultures than SP-treated THP-1 or U937 cultures. Our data indicate that the rs2228145 genotype significantly impacts upon SP-associated IL-6/sIL-6R signalling in vitro, suggesting that it may influence in vivo risk of developing severe COVID-19 and/or long-COVID symptoms following infection by SARS-CoV-2. Thus, the rs2228145 genotype may have potential as a biomarker that differentiates between patients at risk of developing severe and/or prolonged symptoms following infection by SARS-CoV-2 and those who are at less risk.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135739293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coral L. Shuster, Marie C. Tate, Christina T. Schulz, Cheyenne T. Reyes, Megan M. Drohan, Angela G. Astorini, Amy L. Stamates, Manshu Yang, Mark L. Robbins
University students may have experienced heightened levels of stress during the COVID-19 pandemic; however, less is known about coping mechanisms (i.e., approach and avoidance) that were used to manage such stress. Further, there is a need to identify groups of students who may have been at elevated risk for stress. The present study examined the association between coping and perceived stress and whether there were differences in stress based on sociodemographic factors and COVID-19-related changes in employment, housing, and income. Data were collected from 150 university students between the ages of 18 and 25 years (M = 20.68; SD = 1.73). Results indicated that those who endorsed more approach coping skills had lower levels of stress and those who endorsed more avoidance coping skills had higher levels of stress. Additionally, females, those who lost income, and non-heterosexual individuals endorsed higher levels of stress. The results demonstrate the importance of targeted discussions with university students regarding stressors and coping mechanisms.
{"title":"Perceived Stress and Coping among University Students Amidst COVID-19 Pandemic","authors":"Coral L. Shuster, Marie C. Tate, Christina T. Schulz, Cheyenne T. Reyes, Megan M. Drohan, Angela G. Astorini, Amy L. Stamates, Manshu Yang, Mark L. Robbins","doi":"10.3390/covid3100105","DOIUrl":"https://doi.org/10.3390/covid3100105","url":null,"abstract":"University students may have experienced heightened levels of stress during the COVID-19 pandemic; however, less is known about coping mechanisms (i.e., approach and avoidance) that were used to manage such stress. Further, there is a need to identify groups of students who may have been at elevated risk for stress. The present study examined the association between coping and perceived stress and whether there were differences in stress based on sociodemographic factors and COVID-19-related changes in employment, housing, and income. Data were collected from 150 university students between the ages of 18 and 25 years (M = 20.68; SD = 1.73). Results indicated that those who endorsed more approach coping skills had lower levels of stress and those who endorsed more avoidance coping skills had higher levels of stress. Additionally, females, those who lost income, and non-heterosexual individuals endorsed higher levels of stress. The results demonstrate the importance of targeted discussions with university students regarding stressors and coping mechanisms.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anouk Oordt-Speets, Julia Spinardi, Carlos Mendoza, Jingyan Yang, Graciela Morales, John M. McLaughlin, Moe H. Kyaw
Vaccination against infectious disease affords direct protection from vaccine-induced immunity and additional indirect protection for unvaccinated persons. A systematic review was conducted to estimate the indirect effect of COVID-19 vaccination. From PubMed and Embase, 31 studies were included describing the impact of original wild-type COVID-19 vaccines on disease transmission or viral load. Overall, study results showed the effectiveness of COVID-19 vaccination against SARS-CoV-2 transmission (range 16–95%), regardless of vaccine type or number of doses. The effect was apparent, but less pronounced against omicron (range 24–95% for pre-omicron variants versus 16–31% for omicron). Results from viral load studies were supportive, showing SARS-CoV-2 infections in vaccinated individuals had higher Ct values, suggesting lower viral load, compared to infections among the unvaccinated. Based on these findings, well-timed vaccination programs may help reduce SARS-CoV-2 transmission—even in the omicron era. Whether better-matched vaccines can improve effectiveness against transmission in the omicron era needs further study.
{"title":"Effectiveness of COVID-19 Vaccination on Transmission: A Systematic Review","authors":"Anouk Oordt-Speets, Julia Spinardi, Carlos Mendoza, Jingyan Yang, Graciela Morales, John M. McLaughlin, Moe H. Kyaw","doi":"10.3390/covid3100103","DOIUrl":"https://doi.org/10.3390/covid3100103","url":null,"abstract":"Vaccination against infectious disease affords direct protection from vaccine-induced immunity and additional indirect protection for unvaccinated persons. A systematic review was conducted to estimate the indirect effect of COVID-19 vaccination. From PubMed and Embase, 31 studies were included describing the impact of original wild-type COVID-19 vaccines on disease transmission or viral load. Overall, study results showed the effectiveness of COVID-19 vaccination against SARS-CoV-2 transmission (range 16–95%), regardless of vaccine type or number of doses. The effect was apparent, but less pronounced against omicron (range 24–95% for pre-omicron variants versus 16–31% for omicron). Results from viral load studies were supportive, showing SARS-CoV-2 infections in vaccinated individuals had higher Ct values, suggesting lower viral load, compared to infections among the unvaccinated. Based on these findings, well-timed vaccination programs may help reduce SARS-CoV-2 transmission—even in the omicron era. Whether better-matched vaccines can improve effectiveness against transmission in the omicron era needs further study.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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