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Integrative computational approach for gene expression profiling of metastatic breast cancer 转移性乳腺癌基因表达谱的综合计算方法
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_5_23
Aaliya Ashraf, R. Yadav
Background: Breast cancer (BC) is one of the most common cancers in women worldwide, including an estimated 570,000 deaths in 2015. More than 1.5 million women (25% of all women with cancer) are diagnosed with BC every year worldwide. BC is a metastatic cancer and usually spreads to distant organs such as bone, liver, lungs and the brain. Early detection of the disease can lead to better prognosis and higher survival rates. After genome sequencing, DNA microarray analysis has become the most widely used source of genome scale data in life sciences. Microarray's definition studies produce a large number of genetic expression and other genomics performance data, which promises to provide key information on genetic functioning and interaction within and within metabolic pathways. Aim: Prediction and functional enrichment of significant genes expressed in Breast Cancer. Materials and Methods: Microarray data for this study were downloaded from NCBI gene expression omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo), with accession number of GSE157737. It includes four different kind sets of samples, i.e., healthy control neutrophils, healthy donor monocytes, metastatic BC patient G-myeloid-derived suppressor cell (G-MDSCs) and sepsis patient G-MDSCs. The statistical method was applied to identify the differentially expressed gene (DEGs) using Limma package and significant analysis of microarray (SAM) test. Results: The top ten DEGs were identified between different sample sets using Limma package. Out of 32,321 genes, 93 genes were identified to be the significant genes through SAM test. The functional annotation of significant genes was done using different databases such as gene ontology, Kyoto Encyclopedia of Genes and Genomes and Database for Annotation, Visualisation and Integrated Discovery. Significant genes were found to be enriched in haematopoietic cell lineage pathway and the cancer-causing pathway. Conclusions: This research identifies the important genes that have function in BC and regulation of such genes and pathway can be a potential treatment for the BC and prevent the tumour growth.
背景:乳腺癌(BC)是全球女性最常见的癌症之一,2015年估计有57万人死亡。全世界每年有150多万妇女(占所有癌症妇女的25%)被诊断为BC。BC是一种转移性癌症,通常会扩散到远处的器官,如骨、肝、肺和脑。早期发现这种疾病可以带来更好的预后和更高的存活率。继基因组测序之后,DNA微阵列分析已成为生命科学中应用最广泛的基因组数据来源。微阵列的定义研究产生了大量的遗传表达和其他基因组学性能数据,这有望提供遗传功能和代谢途径内部相互作用的关键信息。目的:乳腺癌中重要基因表达的预测及功能富集。材料和方法:本研究的芯片数据从NCBI基因表达综合数据库(GEO) (http://www.ncbi.nlm.nih.gov/geo)下载,登录号为GSE157737。它包括四种不同类型的样本,即健康对照中性粒细胞、健康供体单核细胞、转移性BC患者g -髓源性抑制细胞(G-MDSCs)和败血症患者G-MDSCs。采用统计学方法鉴定差异表达基因(DEGs),采用Limma包装和显著性分析微阵列(SAM)测试。结果:采用Limma包装法在不同样品组间鉴定出前10个deg。在32321个基因中,通过SAM检测鉴定出93个基因为显著基因。利用基因本体、《京都基因与基因组百科全书》、《注释、可视化与综合发现数据库》等数据库对重要基因进行功能标注。在造血细胞谱系途径和致癌途径中发现了显著的基因富集。结论:本研究确定了在BC中起作用的重要基因,调控这些基因和通路可能是治疗BC和防止肿瘤生长的潜在方法。
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引用次数: 1
Clinico-microbiological profile of adults with enteric fever 成人肠热病的临床微生物学特征
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_134_22
Rishikesh Dessai, A. Yadav, A. Garg
Background: Enteric fever is a major public health problem; the burden of disease worldwide is approximately 11.9–26.9 million cases and 129,000–217,000 deaths each year. The burden of disease in India is approximately 6 million per year. Enteric fever is caused by Gram-negative bacteria Salmonella typhi or Salmonella paratyphi A, B or C, which is a bloodstream infection. The re-emergence of susceptibility of old antibiotics such as ampicillin, co-trimoxazole, and chloramphenicol in S. typhi has been observed. Aims: The objective of the study was to study the antibiotic sensitivity pattern of S. typhi, S. paratyphi A and S. paratyphi B and also the clinical and laboratory profile of enteric fever with respect to blood counts, liver function tests and typhoid serology in adult patients with enteric fever. Materials and Methods: The study was conducted in the Department of Internal Medicine and Microbiology at Sir Ganga Ram Hospital in 76 adult patients of blood culture-positive enteric fever. Clinical and laboratory profile of patients was recorded. Antibiotic sensitivity patterns were studied in all cases and the prevalence of multidrug-resistant strains, if the present was established. Results: The mean age in this study was 31.46 + 11.29 years. There were 46 male patients and 30 female patients. Fever was present amongst all patients (100%). Myalgia/headache was present amongst the majority of patients (98.7%). Pain in the abdomen (57.9%) was present. Leucopenia and leucocytosis were present in 25% and 2.6% of patients, respectively. Serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase were abnormal amongst 36.8% and 38.2% of patients, respectively. Complications, such as ileal perforation and gastrointestinal (GI) bleed, were not seen in the patients of enteric fever in this study. Typhidot IgM was positive in 50% of patients. S. typhi (blood culture) was amongst more than half of the patients (69.7%) and S. paratyphi A was 30.3%. Ampicillin was resistant to 5.3% and chloramphenicol and cotrimoxazole each were resistant to 2.6%. Levofloxacin was resistant to 38.2%. Ceftriaxone, azithromycin and cefixime were sensitive to 100%. Multidrug resistance (resistance to ampicillin, chloramphenicol and cotrimoxazole) was seen in 2.6% of cases, which was associated with S. typhi. There was no multidrug resistant (MDR) strain seen with S. paratyphi A. Conclusions: This study showed that fever, myalgia/headache, pain in the abdomen, nausea/vomiting and diarrhoea were the common clinical manifestations of enteric fever. Other important conclusions were low percentages of comorbidities, low occurrence of leucocytosis, high typhidot IgM positivity, low MDR and most of the drugs were 100% sensitive. Ileal perforation and GI bleeding were not found in any case of enteric fever in this study.
背景:肠热是一个重大的公共卫生问题;全世界每年的疾病负担约为1190万至2690万例,死亡12.9万至21.7万例。印度每年的疾病负担约为600万人。肠热是由革兰氏阴性菌伤寒沙门氏菌或副伤寒沙门氏菌A、B或C引起的,这是一种血液感染。观察到伤寒沙门氏菌对氨苄西林、复方新诺明、氯霉素等旧抗生素的敏感性重新出现。目的:研究伤寒沙门氏菌、甲型副伤寒沙门氏菌和乙型副伤寒沙门氏菌的抗生素敏感性模式,以及成年肠炎患者的血球计数、肝功能检查和伤寒血清学的临床和实验室概况。材料和方法:研究在Sir Ganga Ram医院内科和微生物科进行,研究对象为76例血培养阳性肠热成年患者。记录患者的临床和实验室资料。研究了所有病例的抗生素敏感性模式和多重耐药菌株的流行情况,如果目前是确定的。结果:本组患者平均年龄31.46 + 11.29岁。男46例,女30例。所有患者均有发热(100%)。大多数患者(98.7%)存在肌痛/头痛。腹部疼痛(57.9%)。白细胞减少和白细胞增多分别出现在25%和2.6%的患者中。血清谷草转氨酶和谷丙转氨酶异常分别为36.8%和38.2%。本研究未见肠热患者出现回肠穿孔和胃肠道出血等并发症。50%的患者IgM阳性。半数以上患者感染伤寒沙门氏菌(血培养),占69.7%;甲型副伤寒沙门氏菌占30.3%。氨苄西林耐药5.3%,氯霉素和复方新诺明各耐药2.6%。左氧氟沙星耐药率为38.2%。头孢曲松、阿奇霉素和头孢克肟的敏感性为100%。2.6%的病例出现多药耐药(对氨苄西林、氯霉素和复方新诺明耐药),这与伤寒沙门氏菌有关。结论:本研究显示发热、肌痛/头痛、腹痛、恶心/呕吐和腹泻是肠炎热的常见临床表现。其他重要结论是合并症发生率低,白细胞增多症发生率低,伤寒IgM阳性高,耐多药率低,大多数药物100%敏感。本研究未发现任何一例肠热患者出现回肠穿孔和胃肠道出血。
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引用次数: 0
26 years of experience in medical records from 1996 to 2022 从1996年到2022年有26年的医疗记录经验
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_37_23
S. Jena, Parmanand Tiwari, S. Nundy
The importance of maintaining medical records has been well proved and is evident by the advances in this field over the centuries, but in spite of this, record maintenance in India is poor. In this article, we discuss the history of medical record maintenance worldwide and in India as well as its importance. We finally describe our own experience in record maintenance over the last 26 years which was done in a resource-poor setting.
几个世纪以来,这一领域的进步充分证明了维护医疗记录的重要性,但尽管如此,印度的记录维护工作很差。在本文中,我们讨论了世界各地和印度的病历维护历史及其重要性。最后,我们描述了我们在过去26年中在资源贫乏的环境中进行记录维护的经验。
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引用次数: 0
Surgery as an option in adult onset Xanthogranuloma 手术作为成人发病黄色肉芽肿的一种选择
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_1_22
Nikhil Jhunjhunwala, S. Saha
Adult orbital xanthogranulomatous disease (AOXGD) is a group of rare syndromes, involving the periorbital and ocular tissues. We present details of a case of adult-onset xanthogranuloma (AOX) and the management strategy employed in a positive outcome. AOX is the least common variant of AOXGD without any significant systemic involvement. The significance of this entity is that it is often self-limited and is localised to the eye (anterior orbit), with good prognosis. We have kept surgery as our viable primary option in patients presenting late with functional problems and severe cosmetic deformity. In cases with disfiguring lesions and late presentation, the best therapeutic approach is complete excision biopsy and reconstruction with local flaps and full-thickness skin graft. Level of Evidence: Level V, Case report.
成人眼眶黄色肉芽肿病(AOXGD)是一组罕见的综合征,累及眼眶周围和眼部组织。我们详细介绍了一例成人发病的黄色肉芽肿(AOX)和管理策略采用了积极的结果。AOX是AOXGD最不常见的变体,没有明显的系统性累及。这种疾病的重要意义在于它通常是自限性的,并且局限于眼睛(前眼眶),预后良好。对于晚期出现功能问题和严重的外观畸形的患者,我们一直将手术作为可行的主要选择。对于毁容性病变和晚期出现的病例,最好的治疗方法是完全切除、活检和局部皮瓣重建和全层皮肤移植。证据等级:V级,病例报告。
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引用次数: 0
Importance of posters for spreading awareness on HIV/AIDS 海报对传播爱滋病意识的重要性
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_58_23
S. Kakar, Tanvi Batra
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引用次数: 0
Hypomagnesaemia: The esoteric foe in diabetes and diabetic peripheral neuropathy 低镁血症:糖尿病和糖尿病周围神经病变的深奥敌人
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_71_22
Manoj Saluja, P. Sen, Prasad Balachandran, D. Pillai, Saurabh Chittora, Komal Saluja
Background: Diabetes is one of the leading causes of morbidity in India, and diabetic neuropathy is its major complication causing a reduced quality of life. Besides chronic hyperglycaemia, non-glycaemic pathophysiology of insulin resistance and neuronal damage are key to developing novel diabetes management strategies like correcting serum magnesium. Aims: We aimed to analyse hypomagnesemia and its correlation with diabetes and diabetic peripheral neuropathy. Materials and Methods: We conducted a cross sectional study, collecting data for a year (2019-2020) in GMC, Kota. Pearson correlation was performed between serum Magnesium and HbA1C, as well as serum magnesium and nerve conduction parameters. Patients classified based on the absence or presence of neuropathy were compared for various biochemical parameters using Unpaired t-tests, with Welch's correction. Results: Pearson correlation indicates an inverse relationship between hypomagnesemia and hyperglycaemia (HbA1c) (r = -0.5568; P < 0.001), irrespective of neuropathy. Hypomagnesemia has a significant correlation with DPN, such that low serum magnesium has a positive correlation with nerve amplitude (in all the tested nerves) and conduction velocity (in sensory nerves). The pattern of DPN in our study was predominantly sensorimotor axonal polyneuropathy. Mixed axonal and demyelinating neuropathy was seen in sensory nerves. Latency was not affected by serum magnesium concentration in any peripheral nerve tested. T2DM patients with neuropathy had significantly lower serum magnesium, higher HbA1C and serum creatinine than in patients without DPN. Conclusions: Apart from controlling hyperglycaemia, non-glycaemic corrections are also needed to manage the diabetic complications. Serum magnesium and its correlation with disease severity, axonal and demyelinating neuronal injury provides an interesting insight into one such strategy. Further studies are needed to establish the probable role of magnesium supplementation and its benefits in T2DM.
背景:糖尿病是印度发病率的主要原因之一,糖尿病性神经病变是其主要并发症,导致生活质量下降。除慢性高血糖外,胰岛素抵抗和神经元损伤的非血糖病理生理是开发诸如纠正血清镁等新型糖尿病管理策略的关键。目的:我们旨在分析低镁血症及其与糖尿病和糖尿病周围神经病变的关系。材料和方法:我们在Kota GMC进行了一项横断面研究,收集了一年(2019-2020)的数据。血清镁与HbA1C、血清镁与神经传导参数Pearson相关。根据有无神经病变分类的患者,使用未配对t检验比较各种生化参数,并进行Welch校正。结果:Pearson相关性显示低镁血症与高血糖(HbA1c)呈负相关(r = -0.5568;P < 0.001),与神经病变无关。低镁血症与DPN有显著相关性,低血镁与神经振幅(所有被测神经)和传导速度(感觉神经)呈正相关。在我们的研究中,DPN的模式主要是感觉运动轴索多发性神经病。感觉神经有轴突和脱髓鞘混合病变。血清镁浓度对周围神经潜伏期无影响。伴有神经病变的T2DM患者血清镁含量明显低于无DPN患者,HbA1C和血清肌酐含量明显高于无DPN患者。结论:除控制高血糖外,非血糖矫正也需要控制糖尿病并发症。血清镁及其与疾病严重程度、轴突和脱髓鞘神经元损伤的相关性为这种策略提供了有趣的见解。需要进一步的研究来确定补充镁的可能作用及其对2型糖尿病的益处。
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引用次数: 0
The genetic basis of breast cancer: A comprehensive overview 乳腺癌的遗传基础:全面概述
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_100_23
V. Talwar, Arpit Jain
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引用次数: 0
Holi celebrations: Health care-related issues 胡里节庆祝活动:与保健有关的问题
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_63_23
Shanmuganathan Neelamegam
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引用次数: 0
Journey of a denture through the gastrointestinal tract 假牙通过胃肠道的过程
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_129_22
B. Kejriwal, Rakesh Srinivasappa, A. Dey, V. Malik
Foreign-body ingestion and its complications are widely reported and discussed in literature. However, ingested foreign body causing a large-bowel perforation is extremely rare. We present a case of a 49-year-old man who presented to us with complaints of abdominal pain, abdominal distension, fever and obstipation. The patient gave a history of accidental swallowing of his dentures 11 days back. The patient presented with shock in the emergency department and X-ray erect abdomen showed massive air under the diaphragm. The patient was taken for urgent exploratory laparotomy where a sigmoid perforation with ingested denture at the perforation site was found. The perforation was repaired, and a diverting ileostomy was made. The patient had an uneventful post-operative period and was discharged subsequently.
异物摄入及其并发症在文献中被广泛报道和讨论。然而,吞食异物导致大肠穿孔是极为罕见的。我们提出的情况下,一个49岁的男子谁提出了我们的投诉腹痛,腹胀,发烧和顽固。患者11天前有假牙误吞史。病人在急诊科表现为休克,x光显示横膈膜下有大量空气。患者被送往紧急探查剖腹手术,在穿孔部位发现乙状结肠穿孔并摄入义齿。修复了穿孔,并进行了转移回肠造口。患者术后平安无事,随后出院。
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引用次数: 0
Clinical utility of neutrophil-to-lymphocyte ratio in the assessment of asthma and its severity 中性粒细胞与淋巴细胞比值在评估哮喘及其严重程度中的临床应用
Pub Date : 2023-05-01 DOI: 10.4103/cmrp.cmrp_87_22
R. Tahseen, M. Parvez, P. Jahan
Homoeostasis of the immune system is regulated by cell-mediated immune-inflammatory responses. The shift of the immune response is clearly reflected by the cellular ratios than individual cell count. Neutrophil-to-lymphocyte ratio (NLR) serves as a good cell-based marker of inflammation, which is being investigated in various inflammation-related diseases. Asthma which is a chronic inflammatory airway disease associated with hyperresponsiveness, recurrent attacks, wheezing, coughing and chest tightness coupled with multicellular influx of granulocytes with mild-to-severe symptoms of and altered NLR. The aim of the present study was to explore the existing literature on NLR in asthma to realise its clinical utility in asthma and its severity. We searched online database resources 'PubMed' and 'Google Scholar' up till now (20th May, 2022), and studies were included as per eligibility criteria. The data collected were reviewed and analysed. The study included eight published articles on NLR and asthma. The analysis revealed that there is a significant difference in mean NLR between healthy controls and asthma patients (1.57 ± 0.35 vs. 2.36 ± 0.30; P < 0.0001); further, severe versus non-severe asthma cases showed the highest mean NLR as compared to non-severe cases (4.82 ± 2.85 vs. 2.13 ± 0.17; P < 0.0001). Receiver operating curve analysis of NLR showed excellent discriminating capacity, for health versus disease and controlled versus uncontrolled. This mini review suggests NLR can serve as a non-expensive, non-invasive monitoring tool to reduce the risk of exacerbation and hospitalisation. However, large studies are warranted.
免疫系统的稳态是由细胞介导的免疫炎症反应调节的。免疫反应的变化明显地反映在细胞比率而不是单个细胞计数上。中性粒细胞与淋巴细胞比率(NLR)是一种良好的炎症标志物,在各种炎症相关疾病中得到了研究。哮喘是一种慢性炎症性气道疾病,伴有高反应性、反复发作、喘息、咳嗽和胸闷,并伴有粒细胞多细胞涌入,伴有轻度至重度NLR症状和改变。本研究的目的是探讨哮喘NLR的现有文献,以了解其在哮喘及其严重程度中的临床应用。截至目前(2022年5月20日),我们检索了在线数据库资源“PubMed”和“Google Scholar”,并根据入选标准纳入了研究。对收集到的数据进行了审查和分析。该研究包括八篇关于NLR和哮喘的已发表文章。分析显示,健康对照组与哮喘患者的平均NLR差异有统计学意义(1.57±0.35∶2.36±0.30;P < 0.0001);此外,与非严重哮喘患者相比,严重哮喘患者和非严重哮喘患者的平均NLR最高(4.82±2.85∶2.13±0.17;P < 0.0001)。NLR的受试者工作曲线分析显示,NLR对健康与疾病、控制与非控制具有良好的区分能力。这一小型综述表明,NLR可以作为一种非昂贵、非侵入性的监测工具,以降低病情恶化和住院的风险。然而,大规模的研究是有必要的。
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引用次数: 0
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Current medicine research and practice
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