Pub Date : 2024-06-01DOI: 10.56397/crms.2024.06.06
Shuai Tang, Gang Yang
Endoscopic transnasal approach have experienced rapid development and gradual maturation in just a few decades (Kassam AB, Prevedello DM, Carrau RL, et al, 2011; Eloy J A, Vivero R J, Hoang K, et al, 2009). It has expanded from the removal of conventional pituitary tumours to the application of an endoscopic extended transsphenoidal approach for the resection of tumours in the intrasellar, suprasellar and even ventricular systems (Cappabianca P, Cavallo L M, Esposito F, et al, 2008). Larger bone and dural defects at the skull base, causing more severe postoperative complications and resulting in a multiplication of the healthcare burden (Eloy J A, Shukla P A, Choudhry O J, et al, 2013). Skull base Reconstruction after tumour removal has become a great challenge. Currently, skull base reconstruction is mainly divided into soft and rigid reconstruction, and soft reconstruction is represented by the technique of pedicled nasal septum mucosal flap (PNSF) (Thorp B D, Sreenath S B, Ebert C S, et al, 2014)0. As for rigid reconstruction, it is still controversial (Shin J, Forbes J, Lehner K, et al, 2019; Eloy J A, Shukla P A, Choudhry O J, et al, 2012). From the current studies, rigid reconstruction has a role that cannot be ignored. In this article, we will describe the development of skull base surgery and several high-profile skull base reconstruction techniques.
内窥镜经鼻方法在短短几十年间经历了快速发展和逐渐成熟（Kassam AB、Prevedello DM、Carrau RL 等人，2011 年；Eloy J A、Vivero R J、Hoang K 等人，2009 年）。这种方法已从切除传统垂体瘤扩展到应用内窥镜扩展经蝶窦方法切除鞘内、鞘上甚至脑室系统的肿瘤（Cappabianca P、Cavallo L M、Esposito F等人，2008年）。颅底骨质和硬脑膜缺损较大，会引起更严重的术后并发症，导致医疗负担倍增（Eloy J A、Shukla P A、Choudhry O J 等人，2013 年）。肿瘤切除后的颅底重建已成为一项巨大挑战。目前，颅底重建主要分为软性重建和硬性重建，软性重建以带蒂鼻中隔粘膜瓣（PNSF）技术为代表（Thorp B D, Sreenath S B, Ebert C S, et al, 2014）0。 至于硬性重建，目前仍存在争议（Shin J, Forbes J, Lehner K, et al, 2019; Eloy J A, Shukla P A, Choudhry O J, et al, 2012）。从目前的研究来看，刚性重建具有不可忽视的作用。本文将介绍颅底外科的发展以及几种备受瞩目的颅底重建技术。
{"title":"Advances in Skull Base Reconstruction After Transnasal Endoscopy","authors":"Shuai Tang, Gang Yang","doi":"10.56397/crms.2024.06.06","DOIUrl":"https://doi.org/10.56397/crms.2024.06.06","url":null,"abstract":"Endoscopic transnasal approach have experienced rapid development and gradual maturation in just a few decades (Kassam AB, Prevedello DM, Carrau RL, et al, 2011; Eloy J A, Vivero R J, Hoang K, et al, 2009). It has expanded from the removal of conventional pituitary tumours to the application of an endoscopic extended transsphenoidal approach for the resection of tumours in the intrasellar, suprasellar and even ventricular systems (Cappabianca P, Cavallo L M, Esposito F, et al, 2008). Larger bone and dural defects at the skull base, causing more severe postoperative complications and resulting in a multiplication of the healthcare burden (Eloy J A, Shukla P A, Choudhry O J, et al, 2013). Skull base Reconstruction after tumour removal has become a great challenge. Currently, skull base reconstruction is mainly divided into soft and rigid reconstruction, and soft reconstruction is represented by the technique of pedicled nasal septum mucosal flap (PNSF) (Thorp B D, Sreenath S B, Ebert C S, et al, 2014)0. As for rigid reconstruction, it is still controversial (Shin J, Forbes J, Lehner K, et al, 2019; Eloy J A, Shukla P A, Choudhry O J, et al, 2012). From the current studies, rigid reconstruction has a role that cannot be ignored. In this article, we will describe the development of skull base surgery and several high-profile skull base reconstruction techniques.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"42 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141232729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.56397/crms.2024.06.07
Linling Wang, Yao Tang, Hongyu Pan, Zhi-Fei Wen, Xu Cao, Zhi Liu, Ming Wen, Liqiang Zhang
Purpose: To construct a fusion model for predicting CDKN2A/B homozygous deletion status in patients with isocitrate dehydrogenase (IDH)-mutant diffuse astrocytoma by combining the radiomics features and deep learning (DL). Methods: A total of 200 IDH-mutant astrocytoma (103 CDKN2A/B homozygous deletion (HD) and 97 CDKN2A/B non-homozygous deletion (NHD)) patients were retrospectively enrolled in the training cohort (n = 140) and the external test cohort (n = 60) for the prediction of CDKN2A/B homozygous deletion status in patients with IDH-mutant astrocytoma. DL model was constructed by SE-Net model, radiomics features of different regions (edema, tumor and overall lesion) were extracted using Pyradiomics, and radiomics model was built by selecting 4 features in the edema region and 7 features in the tumor region by the least absolute shrinkage and selection operator (LASSO). Finally, a fusion model was jointly constructed by the DL model, radiomics model, and clinical features. The predictive performance of the 3 models was evaluated using calibration curves and decision curves, and compared with the fusion model. Results: Based on the results of the different models, we finally selected a fusion model consisting of DL model, radiomics model, and clinical features. The fusion model showed the best performance with an area under the curve (AUC) of 0.958 in the training cohort and 0.914 in the test cohort. Conclusions: The clinical fusion model based on radiomics features and DL features showed good performance in predicting CDKN2A/B homozygous deletion status in patients with IDH-mutant diffuse astrocytoma. Key Points: 1) Used DL and radiomics to non-invasively predict the CDKN2A/B homozygous deletion status. 2) The model can predict CDKN2A/B homozygous deletion status in IDH-mutant astrocytoma patients. 3) Our result improved classification accuracy and demonstrated better performance in the fusion model.
{"title":"A Clinical Fusion Model Based on Radiomics Features and Deep Learning for Predicting CDKN2A/B Homozygous Deletion Status in IDH-mutant Diffuse Astrocytoma","authors":"Linling Wang, Yao Tang, Hongyu Pan, Zhi-Fei Wen, Xu Cao, Zhi Liu, Ming Wen, Liqiang Zhang","doi":"10.56397/crms.2024.06.07","DOIUrl":"https://doi.org/10.56397/crms.2024.06.07","url":null,"abstract":"Purpose: To construct a fusion model for predicting CDKN2A/B homozygous deletion status in patients with isocitrate dehydrogenase (IDH)-mutant diffuse astrocytoma by combining the radiomics features and deep learning (DL). Methods: A total of 200 IDH-mutant astrocytoma (103 CDKN2A/B homozygous deletion (HD) and 97 CDKN2A/B non-homozygous deletion (NHD)) patients were retrospectively enrolled in the training cohort (n = 140) and the external test cohort (n = 60) for the prediction of CDKN2A/B homozygous deletion status in patients with IDH-mutant astrocytoma. DL model was constructed by SE-Net model, radiomics features of different regions (edema, tumor and overall lesion) were extracted using Pyradiomics, and radiomics model was built by selecting 4 features in the edema region and 7 features in the tumor region by the least absolute shrinkage and selection operator (LASSO). Finally, a fusion model was jointly constructed by the DL model, radiomics model, and clinical features. The predictive performance of the 3 models was evaluated using calibration curves and decision curves, and compared with the fusion model. Results: Based on the results of the different models, we finally selected a fusion model consisting of DL model, radiomics model, and clinical features. The fusion model showed the best performance with an area under the curve (AUC) of 0.958 in the training cohort and 0.914 in the test cohort. Conclusions: The clinical fusion model based on radiomics features and DL features showed good performance in predicting CDKN2A/B homozygous deletion status in patients with IDH-mutant diffuse astrocytoma. Key Points: 1) Used DL and radiomics to non-invasively predict the CDKN2A/B homozygous deletion status. 2) The model can predict CDKN2A/B homozygous deletion status in IDH-mutant astrocytoma patients. 3) Our result improved classification accuracy and demonstrated better performance in the fusion model.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.04
Caiyan Lu, Lin Feng, Lin Feng
Appropriate technology of Chinese medicine, also known as characteristic therapy of Chinese medicine, is also known as the advantageous treatment of Chinese medicine, which is the diagnosis and treatment under the guidance of the basic theoretical knowledge of Chinese medicine. Most of these methods are purely green, without obvious harm and side effects, easy to be accepted by patients and can be implemented in Chinese medicine to play a supplementary therapeutic effect. This paper reviews the significance of Chinese medicine appropriate technology in clinical nursing, the role and mechanism of Chinese medicine appropriate technology, and the identification and application of Chinese medicine appropriate technology, aiming at promoting the complementarity between clinical auxiliary treatment and Chinese medicine appropriate technology, and providing theoretical basis and new ideas for further accelerating the application of Chinese medicine appropriate technology in clinical nursing.
{"title":"A Research Meta-Analysis of Clinical Nursing Combined with Chinese Medicine Appropriate Technology Assisted Treatment","authors":"Caiyan Lu, Lin Feng, Lin Feng","doi":"10.56397/crms.2023.12.04","DOIUrl":"https://doi.org/10.56397/crms.2023.12.04","url":null,"abstract":"Appropriate technology of Chinese medicine, also known as characteristic therapy of Chinese medicine, is also known as the advantageous treatment of Chinese medicine, which is the diagnosis and treatment under the guidance of the basic theoretical knowledge of Chinese medicine. Most of these methods are purely green, without obvious harm and side effects, easy to be accepted by patients and can be implemented in Chinese medicine to play a supplementary therapeutic effect. This paper reviews the significance of Chinese medicine appropriate technology in clinical nursing, the role and mechanism of Chinese medicine appropriate technology, and the identification and application of Chinese medicine appropriate technology, aiming at promoting the complementarity between clinical auxiliary treatment and Chinese medicine appropriate technology, and providing theoretical basis and new ideas for further accelerating the application of Chinese medicine appropriate technology in clinical nursing.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":" 498","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138611058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.07
S.-E. Yang, Xiaohui Han, Shihua Liu, Jianqiang Lan, Aixia Sui
PD-L1 (Programmed Cell Death Protein L1) inhibitor has been used in the first-line treatment of extensive small cell lung cancer, but its prognosis is still poor and its survival time is short, especially in patients with brain metastasis. The effect of PD-1 inhibitor is not satisfactory as well. PD-1 (Programmed Cell Death Protein 1) inhibitors are less effective and used in the third-line treatment, and patients only experience short PSF benefit. Herein, we report a unique case of a patient with brain and adrenal metastases of small cell lung cancer for whom brain metastases partially disappeared, efficacy evaluation at 25 months follow - up PR, quality of life was good, and no significant adverse effects were observed after receiving comprehensive treatment with PD-1 inhibitor Toripalimab.
{"title":"Treatment of Brain Metastasis of Small Cell Lung Cancer with PD-1 Inhibitor: A Case Report","authors":"S.-E. Yang, Xiaohui Han, Shihua Liu, Jianqiang Lan, Aixia Sui","doi":"10.56397/crms.2023.12.07","DOIUrl":"https://doi.org/10.56397/crms.2023.12.07","url":null,"abstract":"PD-L1 (Programmed Cell Death Protein L1) inhibitor has been used in the first-line treatment of extensive small cell lung cancer, but its prognosis is still poor and its survival time is short, especially in patients with brain metastasis. The effect of PD-1 inhibitor is not satisfactory as well. PD-1 (Programmed Cell Death Protein 1) inhibitors are less effective and used in the third-line treatment, and patients only experience short PSF benefit. Herein, we report a unique case of a patient with brain and adrenal metastases of small cell lung cancer for whom brain metastases partially disappeared, efficacy evaluation at 25 months follow - up PR, quality of life was good, and no significant adverse effects were observed after receiving comprehensive treatment with PD-1 inhibitor Toripalimab.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"298 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.08
Jiafeng Xiao
Lumbar disc herniation (LDH), which occurs in male patients aged 20-40 years old, has shown a trend of youthfulness, high incidence and high morbidity in recent years. It is classified as “lumbago” and “paralysis” in Chinese medicine, and is often associated with many pathological factors such as cold, heat, qi, and blood, which makes the TCM patterns of this disease complex and varied, and the clinical application of this disease requires diagnosis and treatment, with qi stagnation and blood stasis patterns being the most common. The treatment of this disease is generally divided into surgical treatment and non-surgical treatment, in which TCM practitioners mostly choose non-surgical treatment methods, such as oral Chinese medicine, acupuncture, massage, etc., which have achieved good efficacy. Therefore, this paper reviews the current status and progress of research on Chinese medicine treatment of lumbar intervertebral disc herniation with qi stagnation and blood stasis over the past 5 years, with the aim of providing clinicians with richer and more mature Chinese medicine treatment programs.
{"title":"Research Progress of Chinese Medicine in the Treatment of Lumbar Intervertebral Disc Herniation of Qi Stagnation and Blood Stasis Type","authors":"Jiafeng Xiao","doi":"10.56397/crms.2023.12.08","DOIUrl":"https://doi.org/10.56397/crms.2023.12.08","url":null,"abstract":"Lumbar disc herniation (LDH), which occurs in male patients aged 20-40 years old, has shown a trend of youthfulness, high incidence and high morbidity in recent years. It is classified as “lumbago” and “paralysis” in Chinese medicine, and is often associated with many pathological factors such as cold, heat, qi, and blood, which makes the TCM patterns of this disease complex and varied, and the clinical application of this disease requires diagnosis and treatment, with qi stagnation and blood stasis patterns being the most common. The treatment of this disease is generally divided into surgical treatment and non-surgical treatment, in which TCM practitioners mostly choose non-surgical treatment methods, such as oral Chinese medicine, acupuncture, massage, etc., which have achieved good efficacy. Therefore, this paper reviews the current status and progress of research on Chinese medicine treatment of lumbar intervertebral disc herniation with qi stagnation and blood stasis over the past 5 years, with the aim of providing clinicians with richer and more mature Chinese medicine treatment programs.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"912 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.03
Ryan Ge
Sarcopenia is characterized by the loss of muscle function and mass as one ages. Muscle stem cells (MuSCs) play a central role to this process, as it is responsible for muscle repair and regeneration. The progressive loss of function in aging skeletal muscle stem cells is thought to be highly influential. This study aims to analyze RNASeq data obtained from young and old skeletal muscle stem cells of Mus musculus and uncover differentially expressed genes between the two groups. These differentially expressed genes were then analyzed to uncover key pathways crucial to the process of MuSC aging. This includes retinol metabolism and neuroactive ligand-receptor interactions.
{"title":"Retinol Metabolism and Neuroactive Ligand-Receptor Interactions Are Key Pathways Involved in Skeletal Muscle Stem Cells (MuSCs) Aging","authors":"Ryan Ge","doi":"10.56397/crms.2023.12.03","DOIUrl":"https://doi.org/10.56397/crms.2023.12.03","url":null,"abstract":"Sarcopenia is characterized by the loss of muscle function and mass as one ages. Muscle stem cells (MuSCs) play a central role to this process, as it is responsible for muscle repair and regeneration. The progressive loss of function in aging skeletal muscle stem cells is thought to be highly influential. This study aims to analyze RNASeq data obtained from young and old skeletal muscle stem cells of Mus musculus and uncover differentially expressed genes between the two groups. These differentially expressed genes were then analyzed to uncover key pathways crucial to the process of MuSC aging. This includes retinol metabolism and neuroactive ligand-receptor interactions.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":" 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Superior Mesenteric Artery Syndrome (SMAS) is a chronic mechanical obstruction of the duodenum due to compression of the superior mesenteric artery (SMA) at the level of the duodenum, with corresponding symptoms that can be improved with postural changes. Gastrointestinal symptoms may improve with positional changes. This kind of disease is very rare in clinic, we now review a case of intractable vomiting caused by superior mesenteric artery syndrome in our hospital, and report the details as follows.
{"title":"A Case of Intractable Vomiting Due to Superior Mesenteric Artery Syndrome","authors":"Minghui Sun, Zhonggang Wu, Shibo Zhao, Huaiyuan Zheng","doi":"10.56397/crms.2023.12.02","DOIUrl":"https://doi.org/10.56397/crms.2023.12.02","url":null,"abstract":"Superior Mesenteric Artery Syndrome (SMAS) is a chronic mechanical obstruction of the duodenum due to compression of the superior mesenteric artery (SMA) at the level of the duodenum, with corresponding symptoms that can be improved with postural changes. Gastrointestinal symptoms may improve with positional changes. This kind of disease is very rare in clinic, we now review a case of intractable vomiting caused by superior mesenteric artery syndrome in our hospital, and report the details as follows.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.01
R. Ayyad, A. Nejm, Yasser Abdel Allem Hassan, Ahmed R. Ayyad
Enzyme inhibition is an important process in the mode of action of many drugs used in the treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic, anti-glaucoma, and anti-malarial drugs act on specific enzymes, leading to bacteriostatic or bactericidal effects, lower blood pressure, reduce cholesterol levels, and cause smooth muscle relaxation of blood vessels. Understanding the mode of action of these drugs and how they affect enzymes is crucial for the development of new drugs and the optimization of existing therapies. This article highlights some various drugs that act through enzyme inhibition and their mechanisms of action.
{"title":"Mechanism of Action of Many Drugs Depend on Enzyme Inhibition","authors":"R. Ayyad, A. Nejm, Yasser Abdel Allem Hassan, Ahmed R. Ayyad","doi":"10.56397/crms.2023.12.01","DOIUrl":"https://doi.org/10.56397/crms.2023.12.01","url":null,"abstract":"Enzyme inhibition is an important process in the mode of action of many drugs used in the treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic, anti-glaucoma, and anti-malarial drugs act on specific enzymes, leading to bacteriostatic or bactericidal effects, lower blood pressure, reduce cholesterol levels, and cause smooth muscle relaxation of blood vessels. Understanding the mode of action of these drugs and how they affect enzymes is crucial for the development of new drugs and the optimization of existing therapies. This article highlights some various drugs that act through enzyme inhibition and their mechanisms of action.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.06
Aihua Dao, Chunhong Pan
Endometrial polyps (EPs) are common gynecological diseases among women of childbearing age. They are formed by the proliferation of blood vessels and connective tissue in a portion of the endometrium, resulting in the formation of a polyp-like mass that protrudes into the uterine cavity and varies in size and number. Typically, the body of the uterus is the site of implantation of these polyp-like growths, which are attached to the medial wall of the uterine cavity by a long, thin tip. Irregular vaginal bleeding is the first clinical manifestation of endometrial polyps, and it can often lead to infertility. Studies have shown that the prevalence of endometrial polyps in the female population is approximately 25.0%. With the widespread use of hysteroscopic techniques in clinical practice, knowledge and diagnosis of endometrial polyps have significantly improved. However, pathological examination remains the “gold standard” for final diagnosis in clinical practice. This article aims to review the epidemiology, pathological histology, and pathogenesis of endometrial polyps to reveal their mechanisms and characteristics more accurately and guide further clinical research and treatment. The relevant progress in recent years in this field, both domestically and internationally, is reviewed below.
{"title":"Advances in the Study of Pathological Histology and Pathogenesis of Endometrial Polyps","authors":"Aihua Dao, Chunhong Pan","doi":"10.56397/crms.2023.12.06","DOIUrl":"https://doi.org/10.56397/crms.2023.12.06","url":null,"abstract":"Endometrial polyps (EPs) are common gynecological diseases among women of childbearing age. They are formed by the proliferation of blood vessels and connective tissue in a portion of the endometrium, resulting in the formation of a polyp-like mass that protrudes into the uterine cavity and varies in size and number. Typically, the body of the uterus is the site of implantation of these polyp-like growths, which are attached to the medial wall of the uterine cavity by a long, thin tip. Irregular vaginal bleeding is the first clinical manifestation of endometrial polyps, and it can often lead to infertility. Studies have shown that the prevalence of endometrial polyps in the female population is approximately 25.0%. With the widespread use of hysteroscopic techniques in clinical practice, knowledge and diagnosis of endometrial polyps have significantly improved. However, pathological examination remains the “gold standard” for final diagnosis in clinical practice. This article aims to review the epidemiology, pathological histology, and pathogenesis of endometrial polyps to reveal their mechanisms and characteristics more accurately and guide further clinical research and treatment. The relevant progress in recent years in this field, both domestically and internationally, is reviewed below.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":"119 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138608386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.56397/crms.2023.12.05
Guangcai Wei, Mei Wang, Yanmei Yang, Fengjie He
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects 6-20% of women of childbearing age (Zafar U, Memon Z, Moin K, et al, 2019). It usually manifests as anovulation or rare ovulation, hirsutism, polycystic ovary changes, and quite common insulin resistance. Due to the heterogeneity of clinical manifestations, there is currently no unified international standard for the diagnosis of PCOS. The etiology and pathogenesis of this syndrome are not fully understood and are generally considered a multifactorial disease with various genetic, endocrine, and metabolic abnormalities.
多囊卵巢综合征(PCOS)是一种复杂的内分泌疾病，影响6-20%的育龄妇女(Zafar U, Memon Z, Moin K, et al .， 2019)。它通常表现为无排卵或罕见排卵，多毛，多囊卵巢改变，以及相当常见的胰岛素抵抗。由于多囊卵巢综合征临床表现的异质性，目前国际上尚无统一的多囊卵巢综合征诊断标准。该综合征的病因和发病机制尚不完全清楚，通常被认为是一种多因素疾病，具有各种遗传、内分泌和代谢异常。
{"title":"Development of Research on the Etiology and Pathogenesis of Polycystic Ovary Syndrome","authors":"Guangcai Wei, Mei Wang, Yanmei Yang, Fengjie He","doi":"10.56397/crms.2023.12.05","DOIUrl":"https://doi.org/10.56397/crms.2023.12.05","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects 6-20% of women of childbearing age (Zafar U, Memon Z, Moin K, et al, 2019). It usually manifests as anovulation or rare ovulation, hirsutism, polycystic ovary changes, and quite common insulin resistance. Due to the heterogeneity of clinical manifestations, there is currently no unified international standard for the diagnosis of PCOS. The etiology and pathogenesis of this syndrome are not fully understood and are generally considered a multifactorial disease with various genetic, endocrine, and metabolic abnormalities.","PeriodicalId":72751,"journal":{"name":"Current research in medical sciences","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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