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Digital detection of craving and stress for individuals in recovery from substance use disorder: A qualitative study 物质使用障碍康复个体渴望和压力的数字检测:一项定性研究
Pub Date : 2025-04-19 DOI: 10.1016/j.dadr.2025.100336
Jazmin Hampton , Reynalde Eugene , Nirzari Kapadia , Emily Caggiano , Amanda Geagea , C. James Watson , Stephanie Carreiro

Aims

This study aims to 1) categorize experiences with stress and craving during substance use disorder (SUD) treatment, 2) explore perceptions of both clients and treatment providers towards a digital detection system for stress and craving during recovery, and 3) identify barriers and facilitators to adopting this technology during SUD treatment.

Methods

This was a qualitative study of people in recovery from SUD (clients) and healthcare providers from outpatient treatment facilities in the northeast United States. Clients were asked to use a digital health tool that detects physiological biomarkers of stress and craving (RAE Health) for 30 days alongside their usual treatment and to engage in a semi-structured interview upon completion. Providers were asked to participate in a one-time focus group.

Results

Thirty-one clients completed a semi-structured interview, and eleven providers participated in two focus groups. Four core themes emerged from the qualitative data: categorization of experiences with stress and craving, perceptions of digital detection systems, perceived barriers and facilitators of the system, and desired features of the system. Overall, client and provider perception were positive, and acceptability of the digital health tool was high.

Conclusions

A digital detection system for stress and craving during SUD recovery was perceived favorably by both clients and providers, with clients citing heightened awareness and providers citing opportunities for personalized care as promising use cases. Future iterations of digital health systems for this population should consider the ideal “dose” of the intervention to maximize benefit.
本研究旨在1)对物质使用障碍(SUD)治疗期间的压力和渴望经历进行分类,2)探索客户和治疗提供者对康复期间压力和渴望数字检测系统的看法,以及3)确定在SUD治疗期间采用该技术的障碍和促进因素。方法本研究是一项定性研究,研究对象为美国东北部门诊治疗机构中从SUD康复的患者和卫生保健提供者。客户被要求使用一种数字健康工具来检测压力和渴望的生理生物标志物(RAE health),为期30天,同时进行常规治疗,并在完成后进行半结构化访谈。提供者被要求参加一个一次性的焦点小组。结果31名客户完成了半结构化访谈,11名服务提供者参加了两个焦点小组。从定性数据中出现了四个核心主题:压力和渴望体验的分类,对数字检测系统的看法,对系统的感知障碍和促进因素,以及系统的期望功能。总体而言,客户和提供者的看法是积极的,数字健康工具的可接受性很高。结论:客户和服务提供者都认为SUD康复期间压力和渴望的数字检测系统是有利的,客户认为提高了意识,服务提供者认为个性化护理的机会是有前景的用例。针对这一人群的数字卫生系统的未来迭代应考虑干预的理想“剂量”,以最大限度地提高效益。
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引用次数: 0
Mental health clinicians’ perceptions on patient motivations and intervention engagement for prenatal cannabis use: A mixed methods study 心理健康临床医生对产前大麻使用患者动机和干预参与的看法:一项混合方法研究
Pub Date : 2025-04-19 DOI: 10.1016/j.dadr.2025.100334
Maha N. Mian , Monique B. Does , Andrea Altschuler , Andrea Green , Deborah R. Ansley , Carley Castellanos , Asma H. Asyyed , Derek D. Satre , Kelly C. Young-Wolff

Background

Mental health clinicians are uniquely suited to support and provide important insights about substance use among pregnant patients. This mixed-methods study explored how mental health clinicians perceive and address prenatal cannabis use.

Methods

Participants were licensed mental health clinicians from Kaiser Permanente Northern California’s Early Start perinatal substance use screening and counseling program. Participants aimed to support patients’ goals for a healthy pregnancy. ESS completed a survey (N = 26; 100 % Female; 73.1 % White; Mage=48.1) and semi-structured interview (n = 14) on their perceptions about patients’ prenatal cannabis use and engagement in the ES program. Interviews were recorded, transcribed coded, and thematically analyzed.

Results

Survey results indicated clinicians perceive that nausea/morning sickness was the most common motive for prenatal cannabis use, and pregnant individuals were most likely to get information about prenatal cannabis use from their peers. Survey and interview results indicated clinicians most often used motivational interviewing, harm reduction, and psychoeducation to address cannabis use. Clinicians reported on psychotherapeutic factors (patient readiness, therapeutic rapport, and mental health support) that facilitate engagement and willingness to quit and/or reduce cannabis use during pregnancy. Other themes included ESS utilization of expertise in complementary mental health topics to support their work.

Conclusions

In this mixed-methods study, clinicians described several approaches to increase pregnant patients’ willingness to engage in perinatal substance use interventions, including eliciting motives for cannabis use and using patient-centered interventions focused on establishing rapport and addressing readiness to quit. Future interventions for patients might incorporate harm reduction and psychoeducation, address motivations for use and readiness to engage in care, emphasize peer support, and support the implementation of complementary interventions.
心理健康临床医生是唯一适合支持和提供怀孕患者药物使用的重要见解。这项混合方法的研究探讨了心理健康临床医生如何感知和解决产前大麻使用问题。方法研究对象是来自北加州Kaiser Permanente早期围产期药物使用筛查和咨询项目的有执照的心理健康临床医生。参与者的目标是支持患者健康怀孕的目标。ESS完成问卷调查(N = 26;100%女性;73.1%白人;法师=48.1)和半结构化访谈(n = 14),了解他们对患者产前大麻使用和参与ES计划的看法。采访被记录下来,转录,编码,并进行主题分析。结果调查结果显示,临床医生认为恶心/孕吐是产前使用大麻的最常见动机,孕妇最有可能从同龄人那里获得产前使用大麻的信息。调查和访谈结果表明,临床医生最常使用动机访谈、减少伤害和心理教育来解决大麻使用问题。临床医生报告了促进怀孕期间戒烟和/或减少使用大麻的参与和意愿的心理治疗因素(患者准备情况、治疗关系和心理健康支持)。其他主题包括ESS利用补充性心理健康专题的专门知识来支持其工作。结论:在这项混合方法的研究中,临床医生描述了几种方法来提高怀孕患者参与围产期物质使用干预的意愿,包括诱导大麻使用动机和使用以患者为中心的干预措施,重点是建立融洽关系和解决戒烟准备问题。未来对患者的干预可能包括减少伤害和心理教育,解决使用动机和参与护理的准备,强调同伴支持,并支持实施补充干预。
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引用次数: 0
The association between race-based bullying and nicotine vaping in adolescents 青少年中基于种族的欺凌与尼古丁电子烟之间的关系
Pub Date : 2025-04-17 DOI: 10.1016/j.dadr.2025.100335
Christina Grimo , Megan Magier , Scott T. Leatherdale , Karen A. Patte

Background

Racialized youth face a higher risk of bullying victimization due to discriminatory bias which can lead to adverse health conditions and increased substance use. This study aimed to examine whether bullying victimization is associated with nicotine vaping, and whether race-based bullying was associated with greater odds of nicotine vaping than other forms of bullying.

Methods

Cross-sectional survey data were used from the COMPASS study collected during the 2022–2023 school year from 14,480 students attending secondary schools in Ontario, Canada. Associations between any bullying victimization (in the last 30 days) and nicotine vaping (≥2 times in the last 30 days), and then among bullied students, between race-based bullying and vaping, were explored using random intercept logistic regression models.

Results

One third (33.4 %) of students who reported race-based bullying engaged in vaping, in comparison to 29.4 % of students who were bullied for other reasons and 15.6 % of nonbullied students. Students who experienced bullying had higher odds (AOR 2.25, 95 % CI [2.03–2.50]) of vaping relative to nonbullied students. Among students who experienced bullying, there was no statistical difference in the odds of vaping between those who reported being bullied due to racial or cultural reasons and their peers who reported being bullied for reasons other than their race or culture (1.16, 95 % CI [0.81–1.67]).

Conclusions

Results suggest that while bullying is strongly associated with vaping among adolescents, being bullied for reasons such as race, culture, or ethnicity does not significantly alter the likelihood of vaping behaviour relative to other forms of bullying.
背景由于歧视性偏见,被歧视的青年面临更大的欺凌受害风险,这可能导致不良的健康状况和更多的药物使用。这项研究旨在研究欺凌受害者是否与尼古丁电子烟有关,以及基于种族的欺凌是否与尼古丁电子烟的可能性比其他形式的欺凌更大有关。方法采用COMPASS研究的横断面调查数据,这些数据收集于2022-2023学年,来自加拿大安大略省的14,480名中学学生。采用随机截距logistic回归模型,探讨任何欺凌受害(最近30天)与尼古丁电子烟(最近30天内≥2次)之间的关系,以及受欺凌学生中基于种族的欺凌与电子烟之间的关系。结果三分之一(33.4%)的种族欺凌学生使用电子烟,相比之下,因其他原因受到欺凌的学生占29.4%,未受欺凌的学生占15.6%。与未受欺凌的学生相比,遭受欺凌的学生吸电子烟的几率更高(AOR 2.25, 95% CI[2.03-2.50])。在遭受欺凌的学生中,报告因种族或文化原因受到欺凌的学生与报告因非种族或文化原因受到欺凌的同龄人之间,吸电子烟的几率没有统计学差异(1.16,95% CI[0.81-1.67])。研究结果表明,虽然欺凌与青少年吸电子烟密切相关,但由于种族、文化或种族等原因受到欺凌,与其他形式的欺凌相比,吸电子烟行为的可能性并没有显著改变。
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引用次数: 0
Minority stress and stimulant use among US adult sexual minority men: A systematic review 美国成年性少数族裔男性中的少数族裔压力和兴奋剂使用:一项系统综述
Pub Date : 2025-04-12 DOI: 10.1016/j.dadr.2025.100333
Michael Miller-Perusse , Keith J. Horvath , Jessica L. Montoya , David J. Moore , Adam W. Carrico , Vanessa B. Serrano

Purpose

Minority stress theory posits health disparities among sexual minority men (SMM; i.e., non-heterosexual) result from experiences of sexual minority stigma (SMS). This systematic review synthesizes quantitative findings on the association between minority stress and stimulant use among US adult SMM.

Methods

PubMed, PsycInfo, CINAHL, and Scopus searches between November 2022 and October 2023 identified 991 studies, with 13 meeting selection criteria: English, peer-reviewed publication reporting an estimated minority stressor–stimulant use association among US adult SMM. Minority stressors included enacted, internalized, or anticipated SMS or identity concealment. Stimulants included methamphetamine, cocaine/crack cocaine, and diverted prescriptions. Proportions of studies and estimates indicating statistically significant associations were examined in total and for each minority stressor–stimulant pair.

Results

Many studies included primarily Black/Latino (69.2 %), urban (76.9 %), young adult samples (38.5 %). Significant associations were reported in 42.9 % (6/13) of studies but represented only 38.2 % (13/34) of unique estimates. Most estimates involving composite stimulant outcomes were nonsignificant (86.7 %, 13/15). Most estimates of enacted SMS–methamphetamine (66.7 %, 2/3), internalized SMS–methamphetamine (66.7 %, 4/6), and internalized SMS–cocaine/crack cocaine (83.3 %, 5/6) associations were significant. Findings suggest sexual orientation (i.e., gay vs bisexual) may moderate internalized SMS effects. Few studies examined prescription stimulants and none examined anticipated SMS or identity concealment.

Conclusions

Further research is needed examining the use of various stimulants independently, not in composite, and testing for moderation by sexual orientation. Findings suggest multi-level approaches targeting enacted SMS and individual-level approaches targeting internalized SMS may benefit SMM who use methamphetamine or cocaine/crack cocaine, respectively.
少数群体压力理论假定性少数男性(SMM)之间的健康差异;例如,非异性恋者)是由于性少数群体耻辱(SMS)的经历造成的。本系统综述综合了美国成年SMM中少数民族压力和兴奋剂使用之间的关联的定量研究结果。方法spubmed、PsycInfo、CINAHL和Scopus在2022年11月至2023年10月期间检索了991项研究,其中13项符合选择标准:英文、同行评审的出版物,报告了美国成人SMM中估计的少数压力源-兴奋剂使用关联。少数民族压力源包括制定的、内化的或预期的短信或身份隐藏。兴奋剂包括甲基苯丙胺、可卡因/快克可卡因和转移处方。研究的比例和估计表明统计上显著的关联被检查了总的和每一个少数压力刺激物对。结果许多研究主要包括黑人/拉丁裔(69.2%)、城市(76.9%)和年轻人(38.5%)。42.9%(6/13)的研究报告了显著相关性,但仅代表38.2%(13/34)的独特估计。大多数涉及复合兴奋剂结果的估计不显著(86.7%,13/15)。制定的短信-甲基苯丙胺(66.7%,2/3)、内化短信-甲基苯丙胺(66.7%,4/6)和内化短信-可卡因/快克可卡因(83.3%,5/6)关联的大多数估计都是显著的。研究结果表明,性取向(即同性恋vs双性恋)可能会缓和内化短信的影响。很少有研究检查处方兴奋剂,也没有研究预期的短信或身份隐瞒。结论需要进一步的研究来检查各种兴奋剂的单独使用,而不是组合使用,并根据性取向进行适度测试。研究结果表明,针对制定短信的多层次方法和针对内化短信的个人层面方法可能分别对使用甲基苯丙胺或可卡因/快克可卡因的SMM有益。
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引用次数: 0
Real-world effectiveness of Motivational Enhancement for Engagement in Treatment (MEET) to improve substance use disorder care transitions 动机增强参与治疗(MEET)改善物质使用障碍护理过渡的现实有效性
Pub Date : 2025-04-11 DOI: 10.1016/j.dadr.2025.100332
Brent R. Crandal , William H. Eger , Naomi Hillery , Amy Panczakiewicz , Zhun Xu , Freddy Arriola , Kelsey S. Dickson

Introduction

Substance use disorder (SUD) treatment effectiveness relies on service continuity during care transitions (e.g., residential to outpatient). Motivational Enhancement for Engagement in Treatment (MEET) is a structured engagement-focused intervention designed to improve service utilization. This study tests the real-world effectiveness of MEET for individuals transitioning between SUD treatment settings.

Methods

Individuals receiving withdrawal management and residential SUD treatment in the San Diego County Behavioral Health Services Drug Medi-Cal Organized Delivery System between March 2021–January 2022 were included in this study. We used logistic regression via generalized estimating equations to calculate adjusted odds ratios (AORs) and 95 % confidence intervals (CIs) that accounted for clustering within treatment facilities and individuals, and stabilized inverse probability of treatment weighting (IPTW) of baseline covariates to assess the probability of connecting to step-down SUD treatment given intervention status (MEET or treatment as usual). We also assessed the probability of timely connection to step-down treatment (i.e., within 10 days of discharge).

Results

Of 10,011 participants in this quasi-experimental study, 141 (1.4 %) received MEET. Participants who received MEET were more likely to be connected to SUD treatment (AOR=1.79, 95 % CI: 1.11, 2.90) and of being connected in ≤ 10 days (AOR=1.65, 95 % CI: 1.01, 2.70) than participants who did not receive the intervention.

Conclusions

Among individuals with a SUD, MEET demonstrated real-world effectiveness for improving connections to step-down care, with participants receiving the intervention having nearly twice the odds of timely connection. This indicates practical engagement-based interventions can improve SUD treatment continuity across care transitions.
物质使用障碍(SUD)的治疗效果依赖于护理过渡期间的服务连续性(例如,从住院到门诊)。动机增强参与治疗(MEET)是一个结构化的参与为重点的干预,旨在提高服务的利用率。本研究测试了MEET对在SUD治疗设置之间过渡的个体的实际有效性。方法选取2021年3月至2022年1月在圣地亚哥县行为健康服务药物医疗- cal有组织递送系统接受戒断管理和住院SUD治疗的个体为研究对象。我们通过广义估计方程使用逻辑回归计算校正优势比(AORs)和95%置信区间(ci),计算治疗设施和个体内的聚类,并稳定基线协变量的治疗加权逆概率(IPTW),以评估在干预状态(MEET或常规治疗)下连接降压性SUD治疗的概率。我们还评估了及时进行降压治疗的可能性(即出院后10天内)。结果在这项准实验研究的10011名参与者中,141人(1.4%)接受了MEET治疗。与未接受干预的参与者相比,接受MEET的参与者更有可能接受SUD治疗(AOR=1.79, 95% CI: 1.11, 2.90),并且在≤10天内(AOR=1.65, 95% CI: 1.01, 2.70)。结论:在患有SUD的个体中,MEET在改善与降服护理的联系方面表现出了现实世界的有效性,接受干预的参与者及时联系的几率几乎是其两倍。这表明基于实际参与的干预措施可以改善整个护理过渡期间SUD治疗的连续性。
{"title":"Real-world effectiveness of Motivational Enhancement for Engagement in Treatment (MEET) to improve substance use disorder care transitions","authors":"Brent R. Crandal ,&nbsp;William H. Eger ,&nbsp;Naomi Hillery ,&nbsp;Amy Panczakiewicz ,&nbsp;Zhun Xu ,&nbsp;Freddy Arriola ,&nbsp;Kelsey S. Dickson","doi":"10.1016/j.dadr.2025.100332","DOIUrl":"10.1016/j.dadr.2025.100332","url":null,"abstract":"<div><h3>Introduction</h3><div>Substance use disorder (SUD) treatment effectiveness relies on service continuity during care transitions (e.g., residential to outpatient). Motivational Enhancement for Engagement in Treatment (MEET) is a structured engagement-focused intervention designed to improve service utilization. This study tests the real-world effectiveness of MEET for individuals transitioning between SUD treatment settings.</div></div><div><h3>Methods</h3><div>Individuals receiving withdrawal management and residential SUD treatment in the San Diego County Behavioral Health Services Drug Medi-Cal Organized Delivery System between March 2021–January 2022 were included in this study. We used logistic regression via generalized estimating equations to calculate adjusted odds ratios (AORs) and 95 % confidence intervals (CIs) that accounted for clustering within treatment facilities and individuals, and stabilized inverse probability of treatment weighting (IPTW) of baseline covariates to assess the probability of connecting to step-down SUD treatment given intervention status (MEET or treatment as usual). We also assessed the probability of timely connection to step-down treatment (i.e., within 10 days of discharge).</div></div><div><h3>Results</h3><div>Of 10,011 participants in this quasi-experimental study, 141 (1.4 %) received MEET. Participants who received MEET were more likely to be connected to SUD treatment (AOR=1.79, 95 % CI: 1.11, 2.90) and of being connected in ≤ 10 days (AOR=1.65, 95 % CI: 1.01, 2.70) than participants who did not receive the intervention.</div></div><div><h3>Conclusions</h3><div>Among individuals with a SUD, MEET demonstrated real-world effectiveness for improving connections to step-down care, with participants receiving the intervention having nearly twice the odds of timely connection. This indicates practical engagement-based interventions can improve SUD treatment continuity across care transitions.</div></div>","PeriodicalId":72841,"journal":{"name":"Drug and alcohol dependence reports","volume":"15 ","pages":"Article 100332"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social media for recovery support for people with substance use disorder. A cross-sectional study of use patterns and motivations 为物质使用障碍患者提供康复支持的社交媒体。使用模式和动机的横断面研究
Pub Date : 2025-04-09 DOI: 10.1016/j.dadr.2025.100331
Chanda Phelan , Abby P.M. Katz , Jennifer E. Merrill , Kristina M. Jackson , Tyler B. Wray

Objective

This study examined the use of social media for recovery support among individuals with substance use disorder (SUD) with past-year treatment attendance and tested whether demographic and SUD history factors were associated with use of social media for recovery support.

Method

Participants (N = 255; 45 % female, 85 % white, mean age = 41.4 [9.6]) recently treated for SUD completed an online survey. The survey gathered demographics, SUD histories, and social media use data. We report descriptive statistics and logistic regression models testing relationships between social media for recovery support and individual factors.

Results

Forty percent of participants used social media for recovery support, and most believed it beneficial. Being female increased use likelihood (OR = 2.56, 95 % CI [1.49, 4.46]), while older age (50 +) was associated with lower use likelihood than young adults (18−35) (OR = 0.35, 95 % CI [0.14, 0.84]). Social media was used primarily to build support systems and follow recovery-related content. Most found support forums on their own, and engaged with the groups for meaningful amounts of time (>weekly, >15 minutes).

Conclusions

Results highlight how common it is to use social media for recovery support. Given the sparse evidence on its efficacy, more research is urgently needed to establish whether recovery support forums on social media convey actual benefits, and how to shape one’s digital environment to maximize those benefits.
目的本研究考察了过去一年参加药物使用障碍(SUD)治疗的个体使用社交媒体进行康复支持的情况,并检验人口统计学和SUD病史因素是否与使用社交媒体进行康复支持有关。方法参与者(N = 255;45%的女性,85%的白人,平均年龄= 41.4[9.6])最近接受了SUD的在线调查。该调查收集了人口统计、SUD历史和社交媒体使用数据。我们报告了描述性统计和逻辑回归模型,测试了社交媒体对恢复支持和个人因素之间的关系。结果40%的参与者使用社交媒体来获得康复支持,大多数人认为这是有益的。女性增加了使用可能性(OR = 2.56, 95% CI[1.49, 4.46]),而年龄较大(50岁以上)的使用可能性低于年轻人(18 - 35)(OR = 0.35, 95% CI[0.14, 0.84])。社交媒体主要用于建立支持系统和跟踪与恢复相关的内容。大多数人都自己找到了支持论坛,并花了大量的时间(每周15分钟)参与其中。研究结果强调了使用社交媒体进行康复支持是多么普遍。鉴于其有效性的证据很少,迫切需要更多的研究来确定社交媒体上的康复支持论坛是否能带来实际的好处,以及如何塑造一个人的数字环境来最大化这些好处。
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引用次数: 0
Impact of recent stimulant use on treatment outcomes amongst individuals initiating medications for opioid use disorders: Secondary analysis of a multisite randomized controlled trial 阿片类药物使用障碍患者近期服用兴奋剂对治疗效果的影响:多站点随机对照试验的二次分析
Pub Date : 2025-04-06 DOI: 10.1016/j.dadr.2025.100330
Cari Coles , Courtney Batts , Joanne Bae , Gabriela León , Alex Schmidt , Sterling M. McPherson , Crystal L. Smith , André C. Miguel

Introduction

Illicit stimulant use among individuals initiating medication for opioid use disorder (MOUD) has significantly increased over the past decade. Co-use of these substances is associated with increased risk of mortality as well as worse treatment outcomes. This study examines the potential predictive role of stimulant urinalysis result at baseline on treatment retention and opioid and stimulant use outcomes amongst individuals initiating MOUD treatment.

Methods

This is a cross-sectional secondary analysis of data from a multi-site randomized clinical trial (CTN-0027). A total of 1269 individuals were randomized to receive 24 weeks of buprenorphine (n = 740) or methadone (n = 529) treatment across nine sites. Multiple linear and logistic regressions were conducted to determine the impact of baseline stimulant urinalysis results on treatment retention, and stimulant and opioid use outcomes.

Results

Individuals initiating MOUD with a stimulant negative urinalysis result at baseline submitted more negative stimulant (ꞵ=7.8; 95 % CI 6.8–8.7) and opioid (ꞵ=2.8; 95 % CI 1.8–3.8) urinalyses during treatment, were more likely to complete treatment (aOR=1.4; 95 % CI 1.1–1.7), and had better outcomes at six-month follow-up, measured as negative urinalysis for stimulant (aOR=5.3; 95 % CI 3.6–7.7), and opioid (aOR=1.8; 95 % CI 1.3–2.6).

Conclusion

Baseline stimulant use is associated with worse MOUD treatment outcomes, underscoring the need for novel integrated interventions designed to address opioid and stimulant co-use.
在过去十年中,开始使用阿片类药物使用障碍(mod)药物的个人中非法兴奋剂的使用显着增加。这些物质的共同使用与死亡风险增加以及治疗结果恶化有关。本研究探讨了兴奋剂尿检结果在基线时对治疗保留和阿片类药物和兴奋剂使用结果的潜在预测作用。方法:本研究是对一项多地点随机临床试验(CTN-0027)数据的横断面二次分析。共有1269人在9个地点随机接受24周的丁丙诺啡(n = 740)或美沙酮(n = 529)治疗。进行了多元线性和逻辑回归,以确定基线兴奋剂尿液分析结果对治疗保留、兴奋剂和阿片类药物使用结果的影响。结果在基线尿检结果为兴奋剂阴性的个体初始化mod时提交了更多的阴性兴奋剂(ꞵ=7.8;95% CI 6.8-8.7)和阿片类药物(ꞵ=2.8;95% CI 1.8-3.8)的患者更有可能完成治疗(aOR=1.4;95% CI 1.1-1.7),并且在6个月的随访中有更好的结果,测量为尿检阴性兴奋剂(aOR=5.3;95% CI 3.6-7.7)和阿片类药物(aOR=1.8;95% ci 1.3-2.6)。结论:基线兴奋剂使用与不良的mod治疗结果相关,强调需要设计新的综合干预措施来解决阿片类药物和兴奋剂的共同使用。
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引用次数: 0
Characterizing withdrawal from long-acting injectable buprenorphine: An observational case series 长效注射丁丙诺啡停药的特征:观察性病例系列
Pub Date : 2025-04-05 DOI: 10.1016/j.dadr.2025.100329
Victoria Hayes , Llewellyn Mills , Gaye Byron , Carolyn Stubley , Eleanor Black , Benjamin T. Trevitt , Andrew A. Somogyi , Arshman Sahid , Nicholas Lintzeris

Introduction

Long-acting injectable buprenorphine (LAIB) products are being increasingly used to treat patients with opioid dependence. Limited data is available on the severity or timespan (time to onset, peak, duration) of withdrawal signs and symptoms following discontinuation of treatment.

Methods

Participants aiming to discontinue long-term LAIB treatment commenced the study on the day of their final dose of Buvidal® 64 mg Monthly. Participants were monitored with weekly assessments of withdrawal severity, cravings, general health, and patient experience measures for up to 16 weeks after last dose.

Results

Fifteen participants – those who remained for at least four weeks after the last LAIB dose – were included in the study. There was minimal increase in withdrawal severity over the study period, with an average peak Clinical Opioid Withdrawal Scale score of 4.8 ± 2.7, occurring at a median of 6 weeks (IQR 4–7.5) after the last LAIB dose. Cravings scores were generally low but increased gradually over the 16-week study period. There was no deterioration in physical or mental health scores, and participants reported high levels of satisfaction with the withdrawal experience. Ten participants used rescue medications, predominately in weeks 5 or 6 after the last dose.

Discussion and conclusions

Participants (last dose of Buvidal® 64 mg Monthly) experienced minimal or mild withdrawal signs and symptoms, usually peaking in severity between 5 and 8 weeks after the last dose. These results are encouraging, however clinical trials comparing withdrawal outcomes between LAIB, sublingual buprenorphine (SL BPN) and methadone are required to inform treatment planning.
长效注射丁丙诺啡(LAIB)产品越来越多地用于治疗阿片类药物依赖患者。关于停药后停药体征和症状的严重程度或时间跨度(发病时间、高峰时间、持续时间)的数据有限。旨在停止长期LAIB治疗的参与者在每月服用Buvidal®64 mg的最后剂量当天开始研究。在最后一次给药后的16周内,每周对参与者进行戒断严重程度、渴望、一般健康状况和患者体验措施的评估。结果15名参与者——在最后一次注射LAIB后至少持续了4周——被纳入研究。在研究期间,戒断严重程度的增加最小,临床阿片类药物戒断量表评分的平均峰值为4.8±2.7,发生在最后一次LAIB剂量后的中位6周(IQR 4-7.5)。渴望得分通常较低,但在16周的研究期间逐渐增加。身体或心理健康得分没有下降,参与者报告对戒断体验的满意度很高。10名参与者使用了抢救药物,主要是在最后一次服药后的第5周或第6周。讨论和结论:参与者(每月最后一次Buvidal®64mg)出现轻微或轻度戒断体征和症状,通常在最后一次给药后5至8周达到严重程度。这些结果令人鼓舞,但是需要临床试验比较LAIB、舌下丁丙诺啡(SL BPN)和美沙酮之间的停药结果,以便为治疗计划提供信息。
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引用次数: 0
Long acting injectable buprenorphine: Perspectives from service-users, staff and stakeholders 长效注射丁丙诺啡:服务使用者、工作人员和利益相关者的观点
Pub Date : 2025-03-29 DOI: 10.1016/j.dadr.2025.100328
Rebecca Fish , Céu Mateus , Hannah Maiden , Euan Lawson , Mark Limmer

Introduction

Long-acting injectable buprenorphine (LAIB) is a relatively novel pharmacological treatment for people with opioid dependence. Despite growing qualitative evidence, there is limited research on practitioner insights, and effectiveness of LAIB in a community setting.

Methods

Thirteen service-users (11 currently prescribed LAIB), 6 practitioners, and 4 stakeholders (public health workers) took part in semi-structured interviews (n = 23) to glean their perspectives on LAIB. They were recruited through a community drug treatment service in the NW of England. The interview schedule was informed by previous literature and co-produced with a peer worker with lived experience of drug recovery treatment. Transcripts were analysed thematically by the research team.

Results

Four major themes were identified from the interviews: A change of focus; challenges; wrap-around support; and target groups.

Discussion

Our findings support existing evidence around the individual benefits to service-users such as changes to lifestyle and reduction of stigma, as well as challenges such as the need for wrap-around support and accessible information. We found that commissioning considerations such as geographical inequalities and the need for multi-service collaboration are important in this setting.

Conclusions

LAIB treatment works well for many people in a community context that offers significant wrap-around support to service-users. The novelty of this research lies in bringing together the views of practitioners and stakeholders as well as treatment/service beneficiaries in evaluating the introduction of LAIB in a community service.
长效注射丁丙诺啡(LAIB)是一种相对较新的阿片类药物依赖药物治疗方法。尽管有越来越多的定性证据,但对从业者的见解和社区环境中LAIB的有效性的研究有限。方法对13名服务使用者(11名现行规定的LAIB)、6名从业人员和4名利益相关者(公共卫生工作者)进行半结构化访谈(n = 23),收集他们对LAIB的看法。他们是通过英格兰西北部的一个社区药物治疗服务机构招募的。访谈时间表参考了以往的文献,并与一位有药物康复治疗生活经验的同行工作者共同制定。研究小组对转录本进行了主题分析。结果从访谈中确定了四个主要主题:焦点的变化;挑战;全方位的支持;目标群体。我们的研究结果支持了现有的证据,证明了服务使用者的个人利益,如生活方式的改变和耻辱的减少,以及对全面支持和可获取信息的需求等挑战。我们发现,在这种情况下,地理不平等和多服务协作需求等调试考虑因素很重要。结论slaib治疗在社区环境中对许多人都有很好的效果,为服务使用者提供了重要的一揽子支持。本研究的新颖之处在于,在评估在社区服务中引入LAIB时,汇集了从业人员和利益相关者以及治疗/服务受益人的观点。
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引用次数: 0
Naloxone training programs in corporately-owned versus independently-owned Alabama community pharmacies: A pilot cross-sectional survey 公司拥有的与独立拥有的阿拉巴马州社区药房的纳洛酮培训计划:一项试点横断面调查
Pub Date : 2025-03-28 DOI: 10.1016/j.dadr.2025.100326
Erin Blythe , Nicholas McCormick , Shannon Woods , Karen Pham , Asia White , Hannah Bricker , Sadie Newhouse , Anne Taylor , Lindsey Hohmann

Introduction

Alabama community pharmacists have the ability to furnish naloxone. The purpose of this study was to identify the differences between naloxone training, policies, procedures, and preferences in corporately-owned (chain) versus independently-owned pharmacies in Alabama.

Methods

An online cross-sectional survey was distributed to Alabama community pharmacists via email. Outcome measures included: 1) in-house versus outsourced naloxone education/training topics (13-item multiple-choice); 2) naloxone training preferences (5-item multiple-choice); and 3) perceived usefulness of naloxone education sources (14-item Likert scale from 1 =strongly disagree to 5 =strongly agree). Data were analyzed using descriptive statistics, 2-sided Fisher’s Exact tests for categorical and Mann Whitney U tests for continuous/ordinal outcomes.

Results

Among the respondents (N = 64), 37 % were female, 95 % White, with an average age of 42 years. Less pharmacists received naloxone training (77 % vs 98 %, p = 0.016), naloxone education mandated by employers (7 % vs 97 %, p < 0.001), and mean[SD] in-house naloxone education topics (3.7[4.9] vs 8.5[4.2], p = 0.003) in independent versus chain pharmacies. Most independent and chain pharmacies preferred naloxone training in an online self-study format (53 % vs 45 %, p = 0.529). However, mean[SD] perceived usefulness of training sources was lower for employer-based training (2.93[0.96] vs 3.90[1.01], p = 0.003), the Alabama Department of Public Health (2.87[1.19] vs 3.66[0.90], p = 0.024), and the Veterans Affairs Administration (1.60[0.91] vs 2.41[0.98], p = 0.013) amongst independents versus chains.

Conclusions

Findings suggest that pharmacists are not all receiving the same training in independent versus chain pharmacies. Targeted training efforts, including development of educational programs tailored to preferences in pharmacy settings, may lead to more efficient and informed provision of naloxone.
阿拉巴马州社区药剂师有能力提供纳洛酮。本研究的目的是确定阿拉巴马州私营(连锁)药店与独立药店的纳洛酮培训、政策、程序和偏好之间的差异。方法通过电子邮件向阿拉巴马州社区药师发放在线横断面调查问卷。结果测量包括:1)内部与外包纳洛酮教育/培训主题(13项多项选择);2)纳洛酮训练偏好(5项选择题);3)纳洛酮教育资源的感知有用性(14项李克特量表从1 =非常不同意到5 =非常同意)。对数据进行描述性统计分析,对分类结果采用双侧Fisher’s Exact检验,对连续/有序结果采用Mann Whitney U检验。结果64例患者中,女性占37%,白人占95%,平均年龄42岁。接受纳洛酮培训(77%对98%,p = 0.016)、雇主要求的纳洛酮教育(7%对97%,p < 0.001)以及独立药房与连锁药店内部纳洛酮教育主题(3.7[4.9]对8.5[4.2],p = 0.003)的平均[SD]较少。大多数独立和连锁药店更喜欢在线自学形式的纳洛酮培训(53%对45%,p = 0.529)。然而,在独立医院和连锁医院中,以雇主为基础的培训的平均[SD]感知有用性较低(2.93[0.96]对3.90[1.01],p = 0.003),阿拉巴马州公共卫生部(2.87[1.19]对3.66[0.90],p = 0.024),退伍军人事务管理局(1.60[0.91]对2.41[0.98],p = 0.013)。结论独立药房和连锁药店的药师接受的培训不尽相同。有针对性的培训工作,包括根据药房设置的偏好制定教育计划,可能会导致更有效和更明智地提供纳洛酮。
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引用次数: 0
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Drug and alcohol dependence reports
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