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CK-MB in serum and in heart and skeletal muscles in patients subjected to mitral valve replacement. 二尖瓣置换术患者血清及心脏和骨骼肌CK-MB含量。
Pub Date : 1980-01-01
R Bendz, S Ström, C Olin

Serum catalytic concentrations of total creatine kinase (CK) and its more heart-specific isoenzyme CK-MB were studied in 25 consecutive patients subjected to isolated mitral valve replacement (Björk--Shiley prosthesis). Heart and skeletal muscle CK and CK-MB content was determined in 10 cases. The postoperative serum levels did not reflect differences in myocardial CK-MB content between patients. CK-MB as a percentage of total CK at peak serum CK-MB (16 +/- 1%) (mean +/- SEM) was of similar order as the percentage of CK-MB in the myocardium (papillary muscle 20.9 +/- 1.3%, right auricle 18.2 +/- 0.5%). A small proportion of CK-MB was present in all skeletal muscle samples examined (diaphragm 4.2 +/- 0.6%, rectus abdominis 0.4 +/- 0.1%), indicating that the total CK level should also be taken into account in attempts to determine the origin of a raised postoperative serum CK-MB activity. The degree of postoperative CK-MB elevation was related to the duration of operation and of aortic cross-clamping. Perioperative myocardial infarction occurred in one patient, and serum CK-MB kinetics in this patient, with a biphasic enzyme curve, differed from those in the other patients.

研究了连续25例接受分离二尖瓣置换术(Björk—Shiley假体)的患者血清总肌酸激酶(CK)及其更具有心脏特异性的同工酶CK- mb的催化浓度。测定10例心脏和骨骼肌CK和CK- mb含量。术后血清CK-MB水平不反映患者间心肌CK-MB含量的差异。峰值血清CK- mb占总CK的百分比(16 +/- 1%)(平均+/- SEM)与心肌CK- mb的百分比(乳头肌20.9 +/- 1.3%,右耳18.2 +/- 0.5%)相似。所有检查的骨骼肌样本中都存在一小部分CK- mb(膈肌4.2 +/- 0.6%,腹直肌0.4 +/- 0.1%),这表明在试图确定术后血清CK- mb活性升高的原因时,还应考虑总CK水平。术后CK-MB升高程度与手术时间和主动脉交叉夹持时间有关。1例患者围手术期发生心肌梗死,该患者血清CK-MB动力学与其他患者不同,具有双相酶曲线。
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引用次数: 0
Blood pressure and vasomotor responses to sympathetic stimuli in patients with chronic myocardial infarction. 慢性心肌梗死患者对交感刺激的血压和血管舒缩反应。
Pub Date : 1980-01-01
E Kellerová, S Cagán, M Kittová

The responses of resistance and capacitance vessels of skin and muscle, and of blood pressure to reflex influences mediated by the sympathetic system were investigated in a group of 63 male patients in a chronic phase of myocardial infarction. In the group of patients with MI, as compared to the controls: (1) the reactive increase of systolic BP and heart rate was significantly smaller but longer lasting after cessation of the stimuli; (2) the vasoconstrictory reactions in skin were significantly prolonged in resistance as well as in capacitance segments of vascular bed; and (3) the resting blood flow in muscle was significantly lower and the vasodilatation during an emotional reaction was less pronounced and shorter. Possible underlying mechanisms of this vasomotor pattern are discussed.

本文研究了63例男性心肌梗死慢性期患者皮肤、肌肉的阻力血管、电容血管和血压对交感神经系统介导的反射影响的反应。心肌梗死组与对照组相比:(1)停止刺激后,收缩压和心率的反应性升高明显较小,但持续时间更长;(2)皮肤血管收缩反应在阻力段和血管床电容段均明显延长;(3)情绪反应时肌肉静息血流量明显降低,血管舒张不明显且时间较短。讨论了这种血管舒缩模式可能的潜在机制。
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引用次数: 0
Clinical electrophysiological properties of penbutolol: a non-selective beta-blocking agent. 戊布托洛尔:一种非选择性阻滞剂的临床电生理特性。
Pub Date : 1980-01-01
E R von Leitner, G Biamino

The electrophysiological effects of the beta-adrenergic blocking agent penbutolol (4 mg i.v.) were studied in 15 patients by means of intracardiac recording using the extra-stimulus technique and rapid atrial pacing. The following effects were observed. (1) Significant prolongation of the sinus cycle length (16%). (2) Significant prolongation of the AV-nodal conduction time during sinus rhythm (12%). (3) Significant prolongation of the AV-nodal conduction time with increasing atrial pacing rate (16--29%). At 150/min, 4 of 7 patients with intact AV-conduction under baseline conditions developed second degree AV-block 15 to 30 min after penbutolol administration. (4) Significant prolongation of the effective refractory period of the AV-node (19%). Penbutolol had no effect on the intraventricular conduction, on intraatrial conduction or on the corrected sinus node recovery time.

采用外刺激法和快速心房起搏法对15例患者进行心内记录,观察肾上腺素能阻滞剂戊布托尔(4mg)的电生理作用。观察到以下效果:(1)窦循环长度明显延长(16%)。(2)窦性心律时av -结传导时间明显延长(12%)。(3)随着心房起搏率的增加,房室结传导时间明显延长(16—29%)。以150/min的速度,基线条件下av传导完整的7例患者中有4例在喷布托洛尔给药后15至30分钟出现二级av传导阻滞。(4) av淋巴结有效不应期明显延长(19%)。喷布托洛尔对脑室内传导、房内传导及窦房结矫正恢复时间均无影响。
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引用次数: 0
Ventricular wall thickness: a predictor of response to vasodilators in cardiomyopathy. 心室壁厚度:心肌病患者对血管扩张剂反应的预测因子。
Pub Date : 1980-01-01
S K Das, O S Randall, T G Steffens

The effect of chronic adjunctive vasodilator therapy was assessed in 14 symptomatic patients with idiopathic cardiomyopathy. Thirteen of the 14 patients improved by one or more in the New York Heart Association functional class, one remained unchanged. Three became asymptomatic (class I). Noninvasive and invasive (hemodynamic) parameters before and after vasodilators were assessed. The echocardiographic findings of septal and posterior wall thickness of 1.2 cm or greater were the best predictors of good response in our patients who subsequently became asymptomatic.

对14例有症状的特发性心肌病患者进行慢性辅助血管扩张剂治疗。在纽约心脏协会的功能分类中,14名患者中有13名得到了一项或多项改善,1名保持不变。3例无症状(I级)。评估血管扩张剂使用前后的无创和有创(血流动力学)参数。超声心动图显示室间隔和后壁厚度为1.2厘米或更厚是我们的无症状患者良好反应的最佳预测指标。
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引用次数: 0
The horizontal interventricular septum. Three cases with different ventriculoarterial connections. 水平室间隔。3例不同脑室动脉连接。
Pub Date : 1980-01-01
M Zach, H Singer, H Löser, K J Hagel

Three hearts sharing the anatomical peculiarity of a horizontal interventricular septum are described. In one, both great vessels originate from the superior right ventricle, in the other the great arteries are connected normally, the third one shows a single aortic trunc. It is concluded that the horizontal interventricular septum has to be considered as an independent cardiac deformity occurring with most types of ventriculoarterial connections. Assuming rotation of the bulboventricular loop around a base-apex-axis as the basic ontogenetic event one can trace this morphology back to its original layout. It is, therefore, possible to classify each case according to the usual nomenclature regarding the horizontal septum and the upstairs-downstairs arrangement of the ventricles as an addition. This embryological event of rotation is considered the product of a restraightening process of the previously looped cardiac tube.

三个心脏共享的解剖特点水平室间隔描述。其中一条,两条大血管都起源于右上心室,另一条大动脉正常连接,第三条显示一条主动脉干。结论:水平室间隔应被认为是一种独立的心脏畸形,发生在大多数类型的心室动脉连接中。假设球室环绕基-顶点轴旋转是基本的个体发生事件,可以将这种形态追溯到其原始布局。因此,可以根据通常的命名法对水平隔膜和心室的上下排列进行分类。这种胚胎学上的旋转事件被认为是先前环路的心管重新拉直过程的产物。
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引用次数: 0
Energetic expenditure during ergometric training after myocardial infarction. 心肌梗死后测力训练期间的能量消耗。
Pub Date : 1980-01-01
P J Birkui

The immediate effects of a single rehabilitation program were appraised in 55 patients with stabilized myocardial infarction (40 inferior and 15 anterior). Subjects were submitted to functional evaluation before and after 20 sessions of interval training on different types of apparatus (cyclorowing, treadmill, bicycle ergometer) and divided into three groups comprising 32, 15 and 8 patients respectively. In both inferior and anterior localization of coronary disease, the predictive value of the energetic indexes Ei1 and Ei2 indicated the improvement in physical fitness resulting from exercise training. For each type of infarct, 15% of the cases studied showed no such improvement after both short- and long-term training. Early changes in energetic indexes are positively correlated with the results of functional evaluation program. Where training is not beneficial, these indexes may therefore be used to help define session by session individualized programs.

对55例稳定型心肌梗死患者(40例为下位心肌梗死,15例为前位心肌梗死)进行单一康复方案的即时效果评价。在不同类型器械(自行车、跑步机、自行车测力器)上进行20次间歇训练前后进行功能评估,并分为3组,分别为32例、15例和8例。在冠状动脉病变的下位和前位,能量指数Ei1和Ei2的预测值提示运动训练对体质的改善。对于每种类型的梗死,15%的研究病例在短期和长期训练后都没有出现这种改善。能量指标的早期变化与功能评价程序的结果呈正相关。在训练没有益处的地方,这些索引因此可以用来帮助定义每个会话的个性化方案。
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引用次数: 0
Echocardiographic diagnosis of mitral valve aneurysm. 二尖瓣动脉瘤的超声心动图诊断。
Pub Date : 1980-01-01
I de Luca, L Colonna

Cases of mitral valve aneurysm determined during the patient's lifetime have not yet been described in literature. Using a mechanical sector scanner we were able to diagnose a mitral valve aneurysm in a 22-yr-old man suffering from rheumatic aortic steno-insufficiency. The real-time, cross-sectional image showed an aneurysm which was limited to the proximal part of the anterior mitral leaflet. During diastole the reflow of blood from the insufficient aorta determined an enlargement of the aneurysm towards the left atrial cavity. Bacterial vegetation which protruded from the aortic valvular surface and which was responsible for abnormal echoes in the M-mode in the left outflow tract was also detected. The patient died of irreversible cardiac insufficiency caused by the infectious endocarditis, and upon autopsy the echocardiographic diagnosis was confirmed.

在患者一生中确定的二尖瓣动脉瘤病例尚未在文献中描述。使用机械扇形扫描仪,我们能够诊断二尖瓣动脉瘤在22岁的男子患有风湿性主动脉狭窄不全。实时,横断面图像显示一个动脉瘤,其局限于前二尖瓣小叶近端。在舒张期,血液从不足的主动脉回流,确定动脉瘤向左心房腔扩张。在左流出道的m型回声中也发现了从主动脉瓣表面突出的细菌植被。患者死于感染性心内膜炎引起的不可逆性心功能不全,经尸检确认超声心动图诊断。
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引用次数: 0
Wolff-Parkinson-White syndrome: disappearance of preexcitation and appearance of complete heart block, probably due to myocardial infarction. Wolff-Parkinson-White综合征:预兴奋消失,出现完全的心脏传导阻滞,可能是由于心肌梗死。
Pub Date : 1980-01-01
R Tur-Kaspa, H O Klein, S Penchas

The appearance and gradual progression of atrioventricular (A-V) block in the presence of the Wolff-Parkinson-White (WPW) syndrome is an intriguing phenomenon. The vast majority of the reports up to date describe persistence of preexcitation in the face of partial or complete heart block. We describe a patient with severe coronary artery disease, in whom WPW disappeared suddenly, transiently at first, during coronary bypass surgery, and then permanently, probably as a result of an acute myocardial infarction, and in whom all the sinus beats during relentlessly progressive heart block were conducted through the normal A-V conduction system only.

Wolff-Parkinson-White (WPW)综合征时房室(A-V)传导阻滞的出现和逐渐发展是一个有趣的现象。到目前为止,绝大多数的报告都描述了面对部分或完全心脏传导阻滞时持续存在的预兴奋。我们描述了一个患有严重冠状动脉疾病的患者,在冠状动脉搭桥手术期间,WPW突然消失,起初是短暂的,然后永久性地消失,可能是急性心肌梗死的结果,并且在无情的进行性心脏传导阻滞期间,所有的窦性搏动仅通过正常的a - v传导系统进行。
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引用次数: 0
Echocardiographic studies of children operated on for congenital heart disease; evaluation during the first postoperative year. 儿童先天性心脏病手术的超声心动图研究术后第一年的评估。
Pub Date : 1980-01-01
G Björkhem, N R Lundström

Fifty-five children in 6 diagnostic groups were followed with repeated echocardiographic examinations during the first postoperative year to establish profiles for different congenital cardiac malformations. One year after total correction, patients with Fallot's anomaly, with and without previous shunt, showed an enlargement of the right ventricular dimension (RVD), the left ventricular internal dimension (LVIDd), the aortic root dimension (AOD), and the left atrial dimension (LAD) compared with normal. In patients with ventricular septal defect (VSD), LVIDd was enlarged; in patients who had been operated on previously with pulmonary banding, both RVD and AOD were enlarged. Patients with VSD and pulmonary stenosis (PS) showed enlarged RVD and AOD but small right ventricular outflow tract (RVOT). Patients with secundum atrial septal defect (ASD) had enlarged RVD, AOD, LVIDd, and LAD. Left ventricular function as judged by echocardiography was normal in all groups pre- and postoperatively. The importance of establishing postoperative echocardiographic profiles is illustrated by patients where deviations from expected findings indicated an unsatisfactory result of the operation and the need for reoperation.

本文对6个诊断组55例患儿进行术后1年多次超声心动图检查,以建立不同先天性心脏畸形的概况。法洛特畸形患者在完全矫正后1年,不论既往是否有分流,均表现为右心室尺寸(RVD)、左心室内尺寸(LVIDd)、主动脉根部尺寸(AOD)和左心房尺寸(LAD)较正常人增大。室间隔缺损(VSD)患者LVIDd增大;既往行过肺动脉束带手术的患者,RVD和AOD均增大。VSD合并肺动脉狭窄(PS)患者RVD和AOD均增大,但右心室流出道(RVOT)较小。继发性房间隔缺损(ASD)患者的RVD、AOD、LVIDd和LAD均增大。术前、术后超声心动图检查各组左心室功能正常。建立术后超声心动图剖面图的重要性体现在与预期结果的偏差表明手术结果不满意并需要再次手术的患者。
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引用次数: 0
Recurrent sustained ventricular tachycardia: report of a case with His-bundle branches reentry as the mechanism. 复发性持续性室性心动过速:以他束分支再入为机制1例报告。
Pub Date : 1980-01-01
C P Reddy, J D Slack

A 57-yr-old man with coronary artery disease presented with recurrent sustained ventricular tachycardia. During electrophysiologic study, the following observations suggested His-bundle branches (His-BB) reentry as the underlying mechanism of ventricular tachycardia: (1) the initiation of ventricular tachycardia by a premature ventricular beat was related to the presence of retrograde His--Purkinje conduction (V2H2) delay; (2) the QRS configuration of tachycardia complexes was similar to that of V1 and V2; (3) each QRS complex of tachycardia was consistently preceded by a His bundle deflection with an H-V interval which was equal to or longer than that of sinus beats; (4) atrioventricular dissociation was present during tachycardia; and (5) after procainamide a greater V2H2 delay was required to initiate the tachycardia. The therapeutic implications of identifying and differentiating the His-BB (macro) reentry from micro reentry are discussed.

一位57岁男性冠心病患者以复发性持续性室性心动过速为主要表现。在电生理学研究中,以下观察结果表明,他束分支(His- bb)再入是室性心动过速的潜在机制:(1)室性心动过速由室性早搏引起的起始与逆行的他—浦肯野传导(V2H2)延迟有关;(2)心动过速复合体QRS构型与V1、V2相似;(3)每次心动过速QRS复合体发生前均有His束偏转,H-V间隔等于或长于窦性心动过速;(4)心动过速时存在房室分离;(5)普鲁卡因胺后,需要更大的V2H2延迟才能启动心动过速。鉴别和区分His-BB(宏观)再入和微再入的治疗意义进行了讨论。
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引用次数: 0
期刊
European journal of cardiology
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