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Persistent left superior vena cava with coronary sinus and left atrial connections. 持续性左上腔静脉伴有冠状窦和左心房连接。
Pub Date : 1980-03-01
P D Bourdillon, R A Foale, J Somerville

A 65-yr-old woman presented with severe congestive cardiac failure and physical signs of an atrial septal defect. Investigation by cardiac catheterisation and cross-sectional echocardiography showed a persistent left superior vena cava draining through an enlarged coronary sinus into the right atrium. In addition, the left atrium was connected to the coronary sinus by two defects in its lateral wall. The atrial septum was intact. The physiological result of this rare anatomical abnormality was a large left-to-right shunt with a small right-to-left component. The defects were closed surgically.

一个65岁的妇女提出严重充血性心力衰竭和房间隔缺损的物理迹象。心导管检查和横断面超声心动图显示持续性左上腔静脉通过扩大的冠状动脉窦引流至右心房。此外,左心房通过其侧壁的两个缺陷与冠状窦相连。房间隔完好无损。这种罕见的解剖异常的生理结果是一个大的左至右分流与一个小的右至左成分。缺损通过手术闭合。
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引用次数: 0
Non-invasive quantification of experimental canine myocardial infarct size using two-dimensional echocardiography. 二维超声心动图对实验性犬心肌梗死面积的无创量化。
Pub Date : 1980-03-01
R S Meltzer, J N Woythaler, A J Buda, J C Griffin, R Kernoff, D C Harrison, R L Popp, R P Martin

In order to study whether wall motion abnormalities detected by two-dimensional (2D) echocardiography can be quantified and correlated with infarct size, we compared wall motion abnormalities viewed by 2D echocardiography in experimental canine infarction with post-mortem infarct size. Nineteen mongrel dogs underwent left anterior descending coronary artery snare occlusion. They were sacrificed 6 h later. Infarct sizing was done by technetium 99-m stannous pyrophosphate scintigraphy of the excised, sliced left ventricles. Fourteen dogs had both 2D echo wall motion abnormalities and infarctions. Four dogs failed to develop infarction and had no or minimal wall motion abnormalities. Inter-observer variation in 2D echocardiographic measurements was small. Wall motion abnormalities correlated with infarct size both in the 14-dog subgroup with infarction (r = 0.75, P less than 0.003) and all the 18 dogs that completed the protocol (r = 0.87, P less than 0.001). Thus, wall motion abnormalities in experimental canine myocardial infraction can be roughly quantified by 2D echocardiography and correlated with post-mortem infarct size measured by scintigraphy.

为了研究二维超声心动图检测到的壁运动异常是否可以量化并与梗死面积相关,我们将实验性犬梗死的二维超声心动图观察到的壁运动异常与死后梗死面积进行了比较。19只杂种狗接受左冠状动脉前降支陷阱闭塞。6小时后处死。用99-m焦磷酸亚锡锝显像对切除的左心室切片进行梗死面积测定。14只犬同时出现二维回声壁运动异常和梗死。4只狗没有发生梗死,没有或只有轻微的壁运动异常。二维超声心动图测量结果的观察者间差异很小。在14只狗梗死亚组(r = 0.75, P < 0.003)和所有18只狗完成方案(r = 0.87, P < 0.001)中,壁运动异常与梗死大小相关。因此,通过二维超声心动图可以大致量化实验性犬心肌梗死的壁运动异常,并与死后超声心动图测量的梗死面积相关。
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引用次数: 0
Problems of rapid digitalization in severe congestive heart failure. 严重充血性心力衰竭的快速数字化治疗问题。
Pub Date : 1980-02-01
K O Haustein, I Assmann, H Fiehring

The pharmacodynamic effects (changes of systolic time intervals, STI, reaction of pulmonary arterial pressure) of digitoxin were studied in 7 patients with severe congestive heart failure in comparison with the corresponding plasma level. STI indicated glycoside-dependent changes, i.e. shortening of LVETc and QS2c and normalization of prolonged PEPc, while ICT shortening was less observed. In 2 patients with cor pulmonale a pulmonary oedema occurred accompanied with prolonged LVETc. During the early period of glycoside-dependent recompensation no significant correlation between STI shortening and glycoside plasma level was observed. Because of the retarded normalization of the haemodynamics of the pulmonary circulation and because of possible side-effects, rapid digitalization has to be reconsidered.

研究了7例重型充血性心力衰竭患者洋地黄素的药效学效应(收缩期间隔变化、STI、肺动脉压反应),并与相应的血浆水平进行了比较。STI显示糖苷依赖性变化,即LVETc和QS2c缩短和延长的PEPc正常化,而ICT缩短较少观察到。2例肺心病患者出现肺水肿伴LVETc延长。在糖苷依赖性再代偿早期,STI缩短与糖苷血浆水平无显著相关性。由于肺循环血流动力学正常化的延迟和可能的副作用,必须重新考虑快速数字化。
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引用次数: 0
Recurrence of myocardial infarction. Observations on patients participating in the Ontario Multicentre Exercise-Heart Trial. 心肌梗死复发。安大略省多中心运动-心脏试验患者观察
Pub Date : 1980-02-01
R J Shephard

The circumstances attending a fatal or non-fatal recurrence of myocardial infarction have been analysed for participants in the Ontario Multicentre Exercise-Heart Trial. After an average of some 20 mth observations, 51 of the 751 participants had sustained a recurrence (rate 4.07 per 100 participant years). Some 24% of episodes were closely associated with various types of physical activity, and a further 22% noted vigorous exercise (sometimes of an unusual nature) a few hours previously. Exercise-related episodes were associated with poor programme compliance and ST segmental depression during test exercise, but were unrelated to the prescribed regimen (high or low intensity physical activity). Continuing smoking and a history of recent angina were associated with a risk of recurrence; both were seen less commonly with recurrence in high intensity exercisers than in their low intensity exercise counterparts. Exercise-induced ST segmental depression was associated with a higher frequency of fatal recurrences in high than in low intensity exercisers (P less than 0.05); there may thus be a 'high-risk' subgroup for whom vigorous exercise is contraindicated, and the existence of such a group could confound therapeutic trials of exercise-centred rehabilitation.

在安大略省多中心运动-心脏试验中,研究人员分析了心肌梗死致死性或非致死性复发的情况。在平均20个月的观察后,751名参与者中有51人持续复发(每100名参与者年的复发率为4.07)。约24%的发作与各种类型的体育活动密切相关,另有22%的发作与几小时前的剧烈运动(有时是不寻常的运动)有关。运动相关的发作与试验运动期间较差的方案依从性和ST段抑郁有关,但与规定的方案(高强度或低强度的身体活动)无关。持续吸烟和近期心绞痛病史与复发风险相关;高强度锻炼者与低强度锻炼者相比,这两种疾病的复发率都较低。运动诱发的ST段抑郁与高强度运动者的致命复发率相关(P < 0.05);因此,可能存在一个“高危”亚组,对他们来说剧烈运动是禁忌的,这样一个群体的存在可能会混淆以运动为中心的康复治疗试验。
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引用次数: 0
Electrophysiological properties of mexiletine assessed with respect to plasma concentrations. 美西汀的电生理特性与血浆浓度的关系。
Pub Date : 1980-02-01
S P Joseph, D W Holt

Electrophysiological measurements were made before and after the intravenous administration of mexiletine in 14 patients with preexcitation syndromes. Following a single infusion of 3 mg/kg body weight plasma concentrations of mexiletine fell rapidly and after 15 min, significant changes in electrophysiological measurements were not found. Higher plasma mexiletine concentrations, bringing about a pharmacological effect, were attained when a second intravenous infusion was also given. The results suggest a minimum effective plasma concentration for mexiletine of about 0.5 mg/l. Side-effects were minimal and their production was largely dependent on the rate of drug infusion. Electrophysiological measurements in previous studies may have been made at a time when plasma mexiletine concentrations were below an effective level and this could explain a disparity in their findings.

对14例预兴奋综合征患者静脉注射美西汀前后进行电生理测量。单次输注3mg /kg体重的美西汀后,血浆浓度迅速下降,15分钟后电生理测量无明显变化。当第二次静脉输注时,血浆美西汀浓度升高,产生药理学效应。结果表明,美西汀的最低有效血药浓度约为0.5 mg/l。副作用很小,其产生在很大程度上取决于药物输注的速度。在以前的研究中,电生理测量可能是在血浆美西汀浓度低于有效水平时进行的,这可以解释他们发现的差异。
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引用次数: 0
Perfusion-fixation of the heart and its conduction system for ultrastructural studies. 心脏灌注固定及其传导系统的超微结构研究。
Pub Date : 1980-02-01
M K Thapar, W W Johnson, S K Sanyal

Nine hearts from children who died from noncardiac causes were perfused within 3 h of death with 2.5% glutaraldehyde, 0.1 M sodium cacodylate, pH 7.2, at 4 degrees C. Each heart was perfused continuously for 4 h using a perfusion pressure of 110 mm Hg. The ultrastructural characteristics of the perfused atrial and ventricular myocardium and conduction system, including sinoatrial, atrioventricular node and Purkinje fibers, were studied. These observations were compared with standard published observations on similar tissues. The results demonstrate that the present method yields comparable results and hence provides a simple, yet effective, means for studying ultrastructural aspects of the heart and its conduction system in children. In addition, this method permits satisfactory gross morphologic examination of the organ.

对9例非心源性死亡患儿在死亡后3 h内灌注2.5%戊二醛、0.1 M草酸钠、pH 7.2、4℃,在110 mm Hg灌注压力下连续灌注4 h,观察灌注后心房和心室心肌及传导系统(包括窦房、房室结和浦肯野纤维)的超微结构特征。将这些观察结果与发表在类似组织上的标准观察结果进行比较。结果表明,目前的方法产生了可比的结果,因此提供了一种简单而有效的方法来研究儿童心脏及其传导系统的超微结构方面。此外,这种方法可以对器官进行令人满意的大体形态学检查。
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引用次数: 0
Further evidence for the site of reentry in so-called sinus node reentrant tachycardia in man. 进一步的证据,在所谓的窦房结再入性心动过速再入的位置在人。
Pub Date : 1980-02-01
G Breithardt, L Seipel

To provide further evidence for the participation of the sinus node in so-called sinus node reentry in man, right atrial stimulation and endocardial mapping were performed in a case with sustained tachycardias which met the commonly accepted criteria for sinus node reentry. In addition to right atrial mapping, the activation of the high left atrium was depicted from the right pulmonary artery. The results clearly showed that in this patient the high right atrium was indeed the site of origin of the atrial echo beats which could be elicited by programmed premature atrial stimulation. The high left atrial electrogram (from the right pulmonary artery) was activated 35 msec after the high right atrium thus excluding the possibility of reentry in Bachmann's bundle. Atrial mapping during echo beats revealed a right atrial activation pattern which was similar to that observed during spontaneous sinus rhythm. Sinus node reentrant beats could also be evoked by programmed premature stimulation of the low lateral right atrium. In conclusion, activation of the high right atrium prior to the high left atrium is an important additional criterion for defining sinus node reentry in man. Thus, the recording of the left atrial signals from the right pulmonary artery helps to exclude reentry in the high left atrium, e.g. Bachmann's bundle.

为了进一步证明窦房结参与了所谓的窦房结再入,我们对一例符合普遍接受的窦房结再入标准的持续性心动过速患者进行了右心房刺激和心内膜测图。除了右心房图外,右肺动脉还描绘了左高心房的激活。结果清楚地表明,在该患者中,右高心房确实是心房回声的起源部位,可以通过程序性过早心房刺激引起心房回声。左心房高位电图(来自右肺动脉)在右心房高位35毫秒后被激活,因此排除了巴赫曼束再入的可能性。回声搏动时的心房标图显示了与自发性窦性心律相似的右心房激活模式。窦房结重入性搏动也可通过程序性过早刺激右心房下外侧引起。总之,右高心房先于左高心房的激活是确定人类窦房结再入的一个重要的附加标准。因此,记录来自右肺动脉的左心房信号有助于排除左心房高位再入,如巴赫曼束。
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引用次数: 0
Right ventricular function at rest and during exercise in patients with coronary heart disease. 冠心病患者静息和运动时的右心室功能。
Pub Date : 1980-02-01
K R Karsch, S Scheufler, H Blanke, P Rentrop

Biplane cineventriculograms of the right ventricle at rest and during exercise were made of 16 patients with a right coronary artery stenosis of greater than 50% and less than 90% to explain the alteration of the volumes and function of the right ventricle during exercise-induced angina pectoris. The right ventricular enddiastolic volume increases from 113 +/- 6.6 ml/m2 to 133.9 +/- 9.8 ml/m2 (P less than 0.001). The endsystolic volume increases from 48.9 +/- 4.1 ml/m2 to 52.9 +/- 5.3 ml/m2. The stroke volume index increases from 64 +/- 5.5 ml/m2 to 81 +/-8.3 ml/m2 (P less than 0.001). At the same time the ejection fraction increases from 56.5 +/- 2.9% to 60.2 +/- 3.2% (P less than 0.05). The left ventricular enddiastolic pressure increases from 12.8 +/- 1.5 mm Hg to 26.6 +/- 1.6 mm Hg (P less than 0.001). The enddiastolic pressure of the right ventricle increases from 5.8 +/- 0.5 to 12.2 +/- 0.8 mm Hg (P less than 0.001). The mean velocity of diameter shortening, VD, increases from 0.9 +/- 0.06 D/s to 1.12 +/- 0.09 D/s (P less than 0.05). Exercise-induced angina pectoris leads to a considerable increase of the left ventricular enddiastolic pressure and therefore to an increase of the right ventricular afterload. The increase of afterload in patients with a right coronary artery stenosis is compensated by a considerable increase of the enddiastolic volume: the pump-function during exercise-induced angina pectoris is maintained by an increase of preload.

本文对16例右冠状动脉狭窄大于50%和小于90%的患者进行静息和运动时的右心室双平面影室图,以解释运动性心绞痛时右心室容量和功能的改变。右心室舒张末期容积从113 +/- 6.6 ml/m2增加到133.9 +/- 9.8 ml/m2 (P < 0.001)。收缩期容积从48.9 +/- 4.1 ml/m2增加到52.9 +/- 5.3 ml/m2。卒中容积指数从64 +/- 5.5 ml/m2增加到81 +/-8.3 ml/m2 (P < 0.001)。同时,射血分数由56.5 +/- 2.9%上升至60.2 +/- 3.2% (P < 0.05)。左室舒张压由12.8 +/- 1.5 mm Hg升高至26.6 +/- 1.6 mm Hg (P < 0.001)。右心室舒张压由5.8 +/- 0.5升高至12.2 +/- 0.8 mm Hg (P < 0.001)。平均直径缩短速度VD由0.9 +/- 0.06 D/s增加到1.12 +/- 0.09 D/s (P < 0.05)。运动性心绞痛导致左心室舒张压显著升高,从而导致右心室后负荷升高。右冠状动脉狭窄患者后负荷的增加可通过舒张期容积的显著增加得到补偿:运动诱发心绞痛时的泵功能是通过增加前负荷来维持的。
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引用次数: 0
Electrophysiologic study of patients with short P-R interval and normal QRS complex. P-R间期短、QRS复合体正常患者的电生理研究。
Pub Date : 1980-02-01
C Moro, F G Cosío

In order to elucidate the electrophysiological nature of the short P-R interval we have studied 15 patients with this phenomenon and a normal QRS complex in the electrocardiogram; none of them had a history of arrhythmias. His bundle electrography and atrial stimulation were used to study the conductivity and refractory periods of the atrioventricular (AV) junction. In 13 cases the studies were repeated after the administration of verapamil. Baseline recordings showed a shortened A-H interval in 6 cases, a shortened H-V interval in 6 and in 3 more with a borderline H-V interval. During rapid atrial pacing A-H interval prolongation was abnormal in 10 cases that showed small increases or sudden prolongations at certain atrial rates. The effective nodal refractory period was shorter than normal. A double AV nodal pathway was demonstrated in one patient and another developed junctional reentrant tachycardias at fixed extrasystolic intervals. After verapamil the A-H interval increased in all but one patient. Significant changes were recorded for the AV nodal refractory periods. In the patient with dual AV nodal conduction verapamil prolonged conduction time and refractory periods through both pathways, and in the one with reentrant tachycardias upon atrial stimulation it abolished the tachycardia. In the presence of a normal QRS, a short P-R interval may be due to shortened conduction time through the AV node, and/or the His-Purkinje network. Our observations tend to rule out the presence of a complete bypass of nodal tissue. Despite the absence of a history of arrhythmias these patients may have electrophysiological abnormalities that predispose them to reentrant AV nodal tachycardias.

为了阐明短P-R间期的电生理性质,我们研究了15例有这种现象和心电图中QRS复合体正常的患者;他们都没有心律失常的病史。他的束电图和心房刺激研究电导率和房室(AV)交界处的不应期。有13例患者在服用维拉帕米后再次进行了研究。基线记录显示6例a - h间期缩短,6例H-V间期缩短,3例H-V间期处于边缘。在快速心房起搏时,10例A-H间期延长不正常,在一定心房率下表现为小幅度增加或突然延长。有效淋巴结不应期明显短于正常。一名患者出现双房室结通路,另一名患者在固定的收缩外间隔出现结性再入性心动过速。维拉帕米治疗后A-H间期均增加,只有1例除外。在房室结不应期记录了显著的变化。在双房室结传导的患者中,维拉帕米延长了传导时间和不应期,在心房刺激后再次进入性心动过速的患者中,维拉帕米消除了心动过速。在QRS正常的情况下,较短的P-R间隔可能是由于通过房室结和/或his -浦肯野神经网络的传导时间缩短。我们的观察倾向于排除淋巴结组织完全旁路的存在。尽管没有心律失常史,但这些患者可能有电生理异常,易发生房室结性心动过速。
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引用次数: 0
Favorable effects of oral digoxin therapy on the left ventricular performance in patients with artificial pacemakers. 口服地高辛治疗对人工起搏器患者左心室功能的有利影响。
Pub Date : 1980-01-01
K Saito, H Tanaka, T Kashima, H Katanasako, M Okamoto, T Kanehisa

The contribution of atrial systole in the left ventricular (LV) function and the effects of oral digoxin maintenance therapy on the LV function were evaluated noninvasively in patients who had artificial pacemakers but no clinical manifestation of congestive heart failure (NYHA Class I). Diastolic dimension (Dd), ejection time (ET), and stroke volume were constant in 8 patients without P waves on their electrocardiograms, but in 20 patients with P waves they were variable from beat to beat because of the variation of the PR intervals which caused them to reach their maximum values when the PR intervals were 160 to 200 msec. Ten out of the 28 patients were given 0.25 mg of digoxin daily for 10 days. Dd did not change significantly, but the ET and the systolic dimension were significantly shortened (P < 0.001). Posterior wall excursion, ejection fraction, and mean posterior wall velocity were significantly increased (P < 0.001). It is concluded that (1) atrial contraction is important to the LV function in patients with artificial pacemakers, and (2) that favorable effects on the LV function can be obtained by a small dose of digoxin administered to the patients who had artificial pacemakers but no congestive heart failure.

对无充血性心力衰竭临床表现(NYHA I类)的人工起搏器患者,无创评价心房收缩对左室功能的贡献及口服地高辛维持治疗对左室功能的影响。8例心电图无P波的患者,舒张尺寸(Dd)、射血时间(ET)、脑卒中容量不变。但在20例有P波的患者中,由于PR间隔的变化,它们在每一次搏动中都是不同的,这使得它们在PR间隔为160到200毫秒时达到最大值。28例患者中有10例每天给予0.25 mg地高辛,持续10天。Dd无明显变化,ET和收缩尺寸明显缩短(P < 0.001)。后壁偏移、射血分数和平均后壁速度显著增加(P < 0.001)。综上所述:(1)心房收缩对人工起搏器患者左室功能有重要影响;(2)对人工起搏器未发生充血性心力衰竭的患者给予小剂量地高辛可对左室功能产生良好影响。
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引用次数: 0
期刊
European journal of cardiology
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