The article presents the theoretical research results of the basic mechanisms of action of accelerated heavy charged particles on the structures of the central nervous system considering their complex geometry. An analysis is performed of spatial distribution regularities of absorbed dose and the probability of hitting different parts of the cell by particles (body, axon, dendrites, spines) when irradiated with charged particles—from protons to iron ions with energies ranging from 10 to 1000 MeV/nucleon. Reactions leading to the formation of both direct and indirect molecular damage in the genetic apparatus and synapses of neurons are considered, involving physical processes that lead to bond rupture as well as chemical reactions with water radiolysis products. The main modeling parameters needed to verify the calculations using experimental results are also discussed. The data can be used for further analysis of radiation risks during interplanetary missions, as well as for evaluating the side effects of hadron therapy.
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