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Clinical utility of the Arabic medication-related burden quality of life (MRB-QoL) tool in hospital-based medicines optimisation services: A mixed methods feasibility study 阿拉伯语药物相关负担生活质量(MRB-QoL)工具在医院药物优化服务中的临床应用:一项混合方法可行性研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-06-03 DOI: 10.1016/j.rcsop.2025.100620
Sundos Q. Al-Ebrahim , Ahmad El Ouweini , Fatima Boura , Heba M. Abu Tayyem , Rami Diab , Omar Adas , Nemah Awwad , Maisam Tobeh , Fatima A.L. Salame , Sara A.L. Jabi , Ghattas Abu Dawoud , Hamzah Alzubaidi , Jeff Harrison , Timothy F. Chen , Mohammed A. Mohammed

Background

The Medication-Related Burden Quality of Life (MRB-QoL) Arabic version is a 31-item valid and reliable measure of medication burden on functioning and well-being in people with long-term conditions.

Aim

To evaluate the feasibility of using the Arabic MRB-QoL tool in clinical pharmacist-led medicines optimisation services in United Arab Emirates (UAE) hospitals.

Method

This non-randomised, non-controlled, feasibility study was conducted in 4 UAE hospitals, utilising a mixed-methods approach. The clinical utility of the MRB-QoL Arabic was evaluated, covering various aspects of feasibility, including acceptability, usability, benefits, facilitators, and barriers to its implementation in practice. The study comprised 3 stages: providing training for clinical pharmacists (CPs) and nurses, implementing the Arabic MRB-QoL tool, and the System Usability Scale (SUS) survey and semi-structured interviews with CPs. The usability and perceived benefits were evaluated using qualitative interviews and a Qualtrics survey. The perceived acceptability, barriers, and facilitators were explored through analysis of the interviews.

Results

Ten CPs implemented the Arabic MRB-QoL tool during routine medication reviews for 227 admitted patients. Thematic analysis of the interview transcripts identified key themes that highlighted the acceptability, usability, benefits, as well as facilitators, and barriers the CPs faced in implementing the tool in their routine clinical practice. In addition, the SUS survey showed an average score of 82.2, indicating excellent usability of the tool in facilitating medicines optimisation services.

Conclusions

This study confirmed the clinical utility of the MRB-QoL Arabic in pharmacist-led medicines optimisation services in UAE hospitals, highlighting preliminary evidence of its acceptability, usability, and benefits, as well as facilitators and barriers to implementation. By promoting patient-centred medicines optimisation, the Arabic MRB-QoL tool has the potential to help healthcare providers gain insights into patients' experiences with medicines and the key dimensions of medication burden patients encounter, optimise medicines regimens, and improve patients' quality of life.
药物相关负担生活质量(MRB-QoL)阿拉伯语版本是一个31项有效和可靠的药物负担对长期疾病患者的功能和福祉的衡量标准。目的评价阿拉伯MRB-QoL工具在阿拉伯联合酋长国(UAE)医院临床药师主导的药物优化服务中的可行性。方法采用混合方法,在阿联酋4家医院进行非随机、非对照的可行性研究。评估了阿拉伯语MRB-QoL的临床应用,涵盖了可行性的各个方面,包括可接受性、可用性、益处、促进因素和在实践中实施的障碍。该研究包括3个阶段:为临床药师和护士提供培训,实施阿拉伯语MRB-QoL工具,系统可用性量表(SUS)调查和对临床药师的半结构化访谈。可用性和感知的好处是通过定性访谈和质量调查来评估的。通过对访谈的分析,探讨了感知可接受性、障碍和促进因素。结果10个CPs在227例住院患者的常规用药评审中采用了阿拉伯语MRB-QoL工具。访谈记录的专题分析确定了重点主题,强调了可接受性、可用性、益处,以及CPs在日常临床实践中实施该工具时面临的促进因素和障碍。此外,SUS调查显示平均得分为82.2,表明该工具在促进药物优化服务方面具有出色的可用性。本研究证实了阿拉伯语MRB-QoL在阿联酋医院药剂师主导的药物优化服务中的临床应用,强调了其可接受性、可用性和益处的初步证据,以及实施的促进因素和障碍。通过促进以患者为中心的药物优化,阿拉伯语MRB-QoL工具有可能帮助医疗保健提供者深入了解患者的用药经历和患者遇到的药物负担的关键方面,优化药物方案,并改善患者的生活质量。
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引用次数: 0
Enhancing pharmacists' engagement and collaboration in sport and exercise medicine: An intervention mapping study using the behaviour change wheel 加强药剂师在运动和运动医学中的参与和合作:使用行为改变轮的干预测绘研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-31 DOI: 10.1016/j.rcsop.2025.100619
Alison D. Hooper , Jodie Marquez , Beata Bajorek , Joyce M. Cooper , David Newby

Background

Pharmacists are accessible, trusted healthcare professionals who are well-positioned to contribute to Sport and Exercise Medicine (SEM), yet their roles remain underutilised. Previous research using the Capability, Opportunity, Motivation-Behaviour (COMB) model identified behavioural barriers and enablers influencing pharmacists' engagement in SEM and collaboration with physiotherapists.

Objective

To design a theory-informed intervention toolkit to enhance pharmacists' engagement in SEM and support pharmacist–physiotherapist collaboration, using the Behaviour Change Wheel (BCW) framework.

Methods

A structured, three-stage intervention mapping approach guided by the BCW was used. This included: (i) understanding behaviour and identifying influencing factors using COM-B analysis; (ii) identifying appropriate intervention functions and supporting policy categories; and (iii) selecting Behaviour Change Techniques (BCTs) and preferred modes of delivery based on the APEASE criteria.

Results

Pharmacists' engagement in SEM is influenced by multiple barriers, including unclear role definitions, limited training and systemic constraints such as time and remuneration. Key enablers include pharmacists' medicines expertise, accessibility and motivation to collaborate. Six intervention functions and five policy categories were identified as suitable. Fifteen BCTs (e.g., goal setting, social support, prompts/cues) were selected to inform intervention content and delivery strategies, with various modes of delivery proposed.

Conclusion

The BCW framework provided a structured method for developing an intervention toolkit aimed at enhancing pharmacists' engagement in SEM and collaboration with physiotherapists. The resulting strategies address key behavioural determinants and offer a foundation for future implementation. However, as the study focused on intervention design rather than implementation, further research is needed to assess the feasibility and real-world impact of the proposed strategies.
药剂师是可访问的,值得信赖的医疗保健专业人员,他们有能力为运动和运动医学(SEM)做出贡献,但他们的角色仍然未得到充分利用。先前的研究使用能力,机会,动机-行为(COMB)模型确定了影响药剂师参与扫描电镜和与物理治疗师合作的行为障碍和使能因素。目的利用行为改变轮(BCW)框架,设计一套基于理论的干预工具,以增强药师对扫描电镜的参与,并支持药师与物理治疗师的合作。方法采用BCW指导下的结构化、三阶段干预制图方法。这包括:(i)利用COM-B分析了解行为并确定影响因素;(ii)确定适当的干预职能和支持政策类别;(iii)根据APEASE标准选择行为改变技术(bct)和首选交付模式。结果影响药师参与电子扫描管理的因素有多种,包括角色定义不清、培训有限以及时间和薪酬等系统性约束。关键的推动因素包括药剂师的药物专业知识、可及性和合作动机。六个干预功能和五个政策类别被确定为合适的。本研究选择了15个BCTs(如目标设定、社会支持、提示/线索)来告知干预内容和实施策略,并提出了各种实施模式。BCW框架为开发干预工具包提供了一种结构化的方法,旨在提高药剂师对扫描电镜的参与以及与物理治疗师的合作。由此产生的战略解决了关键的行为决定因素,并为今后的实施奠定了基础。然而,由于该研究侧重于干预措施的设计而不是实施,因此需要进一步的研究来评估所提出策略的可行性和现实影响。
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引用次数: 0
Impact of clinical pharmacist video-based education on self-care and glycemic control in Sudanese adults with type 2 diabetes: A pre-post interventional study 临床药师视频教育对苏丹成人2型糖尿病患者自我护理和血糖控制的影响:一项干预前后研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-27 DOI: 10.1016/j.rcsop.2025.100617
Safaa Badi , Sara Zainelabdein Suliman , Rayan Almahdi , Mohammed A. Aldomah , Habab Khalid Elkheir , Mohamed Izham Mohamed Ibrahim , Mohamed H. Ahmed

Background

Diabetes affects various body systems, increasing the risk of complications.

Objectives

This study assessed the impact of clinical pharmacist-associated education on diabetes self-care practices and glycemic control in Sudanese individuals with Type 2 Diabetes Mellitus (T2DM).

Design and methods

This quasi-experimental study with no control group recruited 110 adults with T2DM from a diabetes clinic over 12 months using simple random sampling. We collected data through interviews and calls. Participants received 12 educational videos covering diabetes management. The intervention was video-based and delivered over 5 months. We analyzed data using SPSS version 28.

Results

The mean age of participants was 56.2 ± 10.3 years. Self-care practices significantly improved over time. Fasting blood glucose (FBG) levels decreased by 16.7 mg/dL at 6 months (p = 0.009) and 41.9 mg/dL at 12 months (p < 0.001). Two-hour postprandial glucose levels dropped by 18.7 mg/dL at 6 months (p = 0.006) and 61.8 mg/dL at 12 months (p < 0.001). HbA1c levels decreased by 1 % at6 months (p < 0.001) and 1.9 % at 12 months (p < 0.001). The effect size (Cohen's d) was increased from 0.26 at 6 months to 0.74 at 12 months. Similarly, it was increased for 2hrsPPG from 0.2 at 6 months to 0.74 at 12 months. For HbA1c, it was increased from 0.62 at 6 months to 1.25 at 12 months, indicating clinically meaningful improvement in long-term glycemic control following the pharmacist intervention. LDL decreased by 9.2 mg/dL at 12 months (p < 0.001), and HDL increased by 5.5 mg/dL at 12 months (p = 0.002). Changes in BUN and serum creatinine were insignificant.

Conclusion

Clinical pharmacist education improved diabetes self-care practices and metabolic outcomes, including glycemic control and lipid profiles, demonstrating its role in achieving therapeutic goals for patients with T2DM.
糖尿病会影响身体的各个系统,增加并发症的风险。目的:本研究评估临床药师相关教育对苏丹2型糖尿病(T2DM)患者糖尿病自我保健实践和血糖控制的影响。设计与方法本准实验研究无对照组,采用简单随机抽样方法,从糖尿病诊所招募110名成年2型糖尿病患者,为期12个月。我们通过采访和电话收集数据。参与者收到了12个有关糖尿病管理的教育视频。干预以视频为基础,持续时间超过5个月。我们使用SPSS 28版分析数据。结果患者平均年龄为56.2±10.3岁。随着时间的推移,自我护理的做法显著改善。6个月时空腹血糖(FBG)水平下降16.7 mg/dL (p = 0.009), 12个月时下降41.9 mg/dL (p <;0.001)。餐后2小时血糖水平在6个月时下降了18.7 mg/dL (p = 0.006),在12个月时下降了61.8 mg/dL (p <;0.001)。6个月时HbA1c水平下降1% (p <;0.001), 12个月时为1.9% (p <;0.001)。效应量(Cohen’s d)从6个月时的0.26增加到12个月时的0.74。同样,2hrsPPG从6个月时的0.2增加到12个月时的0.74。HbA1c从6个月时的0.62上升到12个月时的1.25,表明药师干预后长期血糖控制有临床意义的改善。12个月时LDL降低9.2 mg/dL (p <;12个月时HDL升高5.5 mg/dL (p = 0.002)。BUN和血清肌酐变化不显著。结论临床药师教育改善了糖尿病患者的自我护理实践和代谢结果,包括血糖控制和脂质谱,证明了其在实现T2DM患者治疗目标中的作用。
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引用次数: 0
An international portrait of pharmacists' professional role identities: A Q-methodology innovative study 药师职业角色认同的国际概况:q -方法论创新研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-26 DOI: 10.1016/j.rcsop.2025.100616
Kaitlyn E. Watson , Theresa J. Schindel , Sherly Meilianti , Ross T. Tsuyuki , Yazid N. Al Hamarneh

Background

Professional identities shape who pharmacists are, what they do, and what they stand for as professionals. Novel research methodologies have potential to illuminate pharmacists' professional identity and roles in new and innovative ways. This study aimed to explore international pharmacists' identity through reflection on their professional roles.

Methods

Q Methodology, which uses quantitative techniques to systematically study subjectivity, was used to allow for an in-depth analysis of professional identity. The participants were self-identified pharmacists working in patient-facing roles who attended the International Pharmaceutical Federation (FIP) Congress in Brisbane, Australia, from September 24–28, 2023. They completed Q methodology online activities to sort the Q-Set within a fixed quasi-normal distribution grid.

Results

Twenty participants completed the Q-Sort activity. Participants came from 10 countries (five of the six World Health Organization regions), two thirds identified as women and approximately one third practiced in hospital and community pharmacy settings, respectively. Three factor arrays are described, which explain 52 % of the variance; Factor 1: Pharmacists as autonomous healthcare providers AND clinical team members; Factor 2: Pharmacists as healthcare providers for individual patients; and Factor 3: Pharmacists as managers first, then healthcare providers.

Conclusion

This study offers a new perspective, revealing how various roles may converge to form a pharmacist's professional role identity: for example, autonomous healthcare providers AND clinical team members AND patient-focused practitioners AND leaders mindful of management responsibilities. Viewing the Q Methodology with a systems thinking lens illuminates pharmacists' professional identities as neither a mere sum of the roles and services they provide, nor represented by a singular aspect of their professional work. Recognizing the complexity of the pharmacists' identities as individuals helps to break free from the cognitive dissonance that has plagued the profession suggesting that professional identity is represented by singular or often competing roles as the scope of pharmacy practice evolves.
职业身份塑造了药剂师是谁,他们做什么,他们作为专业人士代表什么。新颖的研究方法有可能以新的和创新的方式阐明药剂师的职业身份和角色。本研究旨在通过对国际药师职业角色的反思,探讨国际药师的身份认同。方法使用定量技术系统地研究主观性的方法学,允许对职业认同进行深入分析。参与者是自认为是面向患者的药剂师,他们参加了2023年9月24日至28日在澳大利亚布里斯班举行的国际制药联合会(FIP)大会。他们完成了Q方法学在线活动,在固定的准正态分布网格内对Q集进行排序。结果20名参与者完成了Q-Sort活动。参与者来自10个国家(世界卫生组织六个区域中的五个),三分之二被确定为妇女,大约三分之一分别在医院和社区药房工作。描述了三个因素阵列,它们解释了52%的方差;因素1:药师作为自主医疗服务提供者和临床团队成员;因素2:药剂师作为个体患者的医疗保健提供者;因素3:药剂师首先是管理者,然后是医疗服务提供者。结论本研究提供了一个新的视角,揭示了不同的角色如何汇聚形成药剂师的职业角色认同:例如,自主的医疗保健提供者和临床团队成员以及以患者为中心的从业者和关注管理责任的领导者。用系统思维的视角来看待Q方法论,说明药剂师的职业身份既不是他们提供的角色和服务的简单总和,也不是他们专业工作的单一方面。认识到药剂师作为个体身份的复杂性有助于摆脱困扰该职业的认知失调,这表明随着药学实践范围的发展,职业身份由单一或经常竞争的角色代表。
{"title":"An international portrait of pharmacists' professional role identities: A Q-methodology innovative study","authors":"Kaitlyn E. Watson ,&nbsp;Theresa J. Schindel ,&nbsp;Sherly Meilianti ,&nbsp;Ross T. Tsuyuki ,&nbsp;Yazid N. Al Hamarneh","doi":"10.1016/j.rcsop.2025.100616","DOIUrl":"10.1016/j.rcsop.2025.100616","url":null,"abstract":"<div><h3>Background</h3><div>Professional identities shape who pharmacists are, what they do, and what they stand for as professionals. Novel research methodologies have potential to illuminate pharmacists' professional identity and roles in new and innovative ways. This study aimed to explore international pharmacists' identity through reflection on their professional roles.</div></div><div><h3>Methods</h3><div>Q Methodology, which uses quantitative techniques to systematically study subjectivity, was used to allow for an in-depth analysis of professional identity. The participants were self-identified pharmacists working in patient-facing roles who attended the International Pharmaceutical Federation (FIP) Congress in Brisbane, Australia, from September 24–28, 2023. They completed Q methodology online activities to sort the Q-Set within a fixed quasi-normal distribution grid.</div></div><div><h3>Results</h3><div>Twenty participants completed the Q-Sort activity. Participants came from 10 countries (five of the six World Health Organization regions), two thirds identified as women and approximately one third practiced in hospital and community pharmacy settings, respectively. Three factor arrays are described, which explain 52 % of the variance; Factor 1: Pharmacists as autonomous healthcare providers AND clinical team members; Factor 2: Pharmacists as healthcare providers for individual patients; and Factor 3: Pharmacists as managers first, then healthcare providers.</div></div><div><h3>Conclusion</h3><div>This study offers a new perspective, revealing how various roles may converge to form a pharmacist's professional role identity: for example, autonomous healthcare providers AND clinical team members AND patient-focused practitioners AND leaders mindful of management responsibilities. Viewing the Q Methodology with a systems thinking lens illuminates pharmacists' professional identities as neither a mere sum of the roles and services they provide, nor represented by a singular aspect of their professional work. Recognizing the complexity of the pharmacists' identities as individuals helps to break free from the cognitive dissonance that has plagued the profession suggesting that professional identity is represented by singular or often competing roles as the scope of pharmacy practice evolves.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"19 ","pages":"Article 100616"},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can we involve pharmacists as direct service providers for people with tuberculosis? A narrative review of current evidence 我们能否让药剂师成为结核病患者的直接服务提供者?对当前证据的叙述性回顾
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-18 DOI: 10.1016/j.rcsop.2025.100613
Cut Ainul Mardhiyyah , Kevin Aprilio , Sumarheni , Shubashini Gnanasan , Dian Ayu Eka Pitaloka , Ivan Surya Pradipta

Background

Effective management of tuberculosis (TB) necessitates the utilization of all available healthcare resources. Despite a paradigm shift in pharmacy practice from a product-centric to a patient-centered model, pharmacists remain underutilized in direct TB care. This narrative review explores the role of pharmacists in TB management, highlighting the effects of direct pharmaceutical care (PC) practices for TB treatment outcomes by identifying challenges and proposing strategic interventions to enhance pharmacists' engagement in TB services.

Methods

We conducted a literature search across major medical databases to describe existing studies on the effect of direct PC practice on TB case management. We then discussed the challenges and potential strategies for its implementation.

Results

We identified several PC models, including drug therapy monitoring, home-based care, patient counseling, and adherence support. These models mitigate drug-related problems, adverse drug reactions, and medication non-adherence. However, pharmacists face numerous barriers to providing direct TB care, including insufficient clinical training, limited interdisciplinary collaboration, a lack of organizational support and incentives, inadequate regulatory frameworks, and low awareness of pharmacists' potential contributions. To address these challenges, proposed strategies include strengthening pharmacist education and training, fostering collaboration within healthcare teams, developing standardized practice guidelines, ensuring adequate facilities and financial support, and increasing awareness among policymakers and the public on pharmacists' roles in TB care.

Conclusion

Strengthening the role of pharmacists in TB management requires a multi-faceted approach involving targeted policy reforms, enhanced professional training, and interdisciplinary collaboration. A coordinated effort among national and local TB programs, healthcare institutions, professional organizations, and academic institutions is essential to optimize pharmacists' contributions to TB prevention, treatment, and patient support.
背景有效的结核病管理需要利用所有可用的医疗资源。尽管药房实践从以产品为中心的模式转变为以患者为中心的模式,但药剂师在直接结核病治疗中仍未得到充分利用。这篇叙述性综述探讨了药剂师在结核病管理中的作用,通过确定挑战并提出战略性干预措施以加强药剂师参与结核病服务,突出了直接药物护理(PC)实践对结核病治疗结果的影响。方法我们在主要的医学数据库中进行了文献检索,以描述关于直接PC实践对结核病病例管理影响的现有研究。然后,我们讨论了其实施的挑战和潜在战略。结果我们确定了几种PC模式,包括药物治疗监测、家庭护理、患者咨询和依从性支持。这些模型减轻了药物相关问题,药物不良反应和药物不依从性。然而,药剂师在提供直接结核病治疗方面面临许多障碍,包括临床培训不足、跨学科合作有限、缺乏组织支持和激励、监管框架不足以及对药剂师潜在贡献的认识不足。为了应对这些挑战,拟议的战略包括加强药剂师的教育和培训,促进卫生保健团队内部的合作,制定标准化的实践指南,确保充足的设施和财政支持,以及提高决策者和公众对药剂师在结核病治疗中的作用的认识。结论加强药师在结核病管理中的作用需要采取多方面的措施,包括有针对性的政策改革、加强专业培训和跨学科合作。国家和地方结核病规划、卫生保健机构、专业组织和学术机构之间的协调努力对于优化药剂师对结核病预防、治疗和患者支持的贡献至关重要。
{"title":"Can we involve pharmacists as direct service providers for people with tuberculosis? A narrative review of current evidence","authors":"Cut Ainul Mardhiyyah ,&nbsp;Kevin Aprilio ,&nbsp;Sumarheni ,&nbsp;Shubashini Gnanasan ,&nbsp;Dian Ayu Eka Pitaloka ,&nbsp;Ivan Surya Pradipta","doi":"10.1016/j.rcsop.2025.100613","DOIUrl":"10.1016/j.rcsop.2025.100613","url":null,"abstract":"<div><h3>Background</h3><div>Effective management of tuberculosis (TB) necessitates the utilization of all available healthcare resources. Despite a paradigm shift in pharmacy practice from a product-centric to a patient-centered model, pharmacists remain underutilized in direct TB care. This narrative review explores the role of pharmacists in TB management, highlighting the effects of direct pharmaceutical care (PC) practices for TB treatment outcomes by identifying challenges and proposing strategic interventions to enhance pharmacists' engagement in TB services.</div></div><div><h3>Methods</h3><div>We conducted a literature search across major medical databases to describe existing studies on the effect of direct PC practice on TB case management. We then discussed the challenges and potential strategies for its implementation.</div></div><div><h3>Results</h3><div>We identified several PC models, including drug therapy monitoring, home-based care, patient counseling, and adherence support. These models mitigate drug-related problems, adverse drug reactions, and medication non-adherence. However, pharmacists face numerous barriers to providing direct TB care, including insufficient clinical training, limited interdisciplinary collaboration, a lack of organizational support and incentives, inadequate regulatory frameworks, and low awareness of pharmacists' potential contributions. To address these challenges, proposed strategies include strengthening pharmacist education and training, fostering collaboration within healthcare teams, developing standardized practice guidelines, ensuring adequate facilities and financial support, and increasing awareness among policymakers and the public on pharmacists' roles in TB care.</div></div><div><h3>Conclusion</h3><div>Strengthening the role of pharmacists in TB management requires a multi-faceted approach involving targeted policy reforms, enhanced professional training, and interdisciplinary collaboration. A coordinated effort among national and local TB programs, healthcare institutions, professional organizations, and academic institutions is essential to optimize pharmacists' contributions to TB prevention, treatment, and patient support.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"19 ","pages":"Article 100613"},"PeriodicalIF":1.8,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of mRNA COVID-19 vaccination on hematological parameters in patients maintained on clozapine: A retrospective study from Qatar mRNA COVID-19疫苗接种对氯氮平维持患者血液学参数的影响:来自卡塔尔的回顾性研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-18 DOI: 10.1016/j.rcsop.2025.100614
Dalia Albahari , Oraib Abdallah , Shatha Mahmud Ismail Alqam , Mohammed Faisal Hamad Mohammed , Mohamed Ali Siddig Ahmed , Ovais Wadoo

Background

COVID-19 vaccines are known to cause transient changes in white blood cell counts as part of the immune activation process. Clozapine, an antipsychotic agent primarily prescribed for treatment-resistant schizophrenia, possesses both immunosuppressive and pro-inflammatory properties that may influence vaccine-related immune responses. The concurrent use of clozapine during COVID-19 vaccination has therefore raised concerns regarding potential hematological adverse effects. Despite increasing global research in this area, data from Arab populations remain scarce, highlighting the need for region-specific evidence. This study aimed to investigate the incidence of white blood cell and absolute neutrophil count abnormalities in patients receiving clozapine who were vaccinated with mRNA COVID-19 vaccines.

Method

A retrospective study was conducted within Qatar's public mental health services. The study included patients on clozapine who received at least one dose of a COVID-19 vaccine between February 2020 and November 2022. Hematological parameters were assessed at three time points: pre-vaccination, shortly post-vaccination, and three months post-vaccination. Demographic, clinical, and vaccine-related factors were also examined.

Results

Of 111 vaccinated patients, 74 had complete blood test data across the three time points. No cases of agranulocytosis or other serious hematological adverse effects were observed. Mild leukopenia occurred in 6.8–8.1 % of patients, and mild neutropenia in 5.4–6.8 %. These changes were transient and not associated with clozapine dosage, vaccine type, or other clinical variables.

Conclusion

COVID-19 mRNA vaccines appear safe for individuals maintained on clozapine, with only minor, temporary changes in white blood cell counts. These findings support continued vaccination efforts in this population.
作为免疫激活过程的一部分,已知covid -19疫苗会引起白细胞计数的短暂变化。氯氮平是一种主要用于治疗抵抗性精神分裂症的抗精神病药物,具有免疫抑制和促炎特性,可能影响疫苗相关的免疫反应。因此,在COVID-19疫苗接种期间同时使用氯氮平引起了对潜在血液学不良反应的担忧。尽管在这一领域的全球研究越来越多,但来自阿拉伯人口的数据仍然很少,这突出表明需要针对特定区域的证据。本研究旨在探讨接种mRNA - COVID-19疫苗的氯氮平患者白细胞和绝对中性粒细胞计数异常的发生率。方法对卡塔尔公共精神卫生服务机构进行回顾性研究。该研究包括在2020年2月至2022年11月期间接受氯氮平至少一剂COVID-19疫苗的患者。在三个时间点评估血液学参数:接种前、接种后不久和接种后三个月。还检查了人口统计学、临床和疫苗相关因素。结果111例接种疫苗的患者中,74例在三个时间点具有完整的血液检测数据。无粒细胞缺乏症或其他严重的血液学不良反应。轻度白细胞减少发生率为6.8 - 8.1%,轻度中性粒细胞减少发生率为5.4 - 6.8%。这些变化是短暂的,与氯氮平剂量、疫苗类型或其他临床变量无关。结论covid -19 mRNA疫苗对维持氯氮平治疗的个体是安全的,白细胞计数只有轻微的、暂时的变化。这些发现支持在这一人群中继续开展疫苗接种工作。
{"title":"Impact of mRNA COVID-19 vaccination on hematological parameters in patients maintained on clozapine: A retrospective study from Qatar","authors":"Dalia Albahari ,&nbsp;Oraib Abdallah ,&nbsp;Shatha Mahmud Ismail Alqam ,&nbsp;Mohammed Faisal Hamad Mohammed ,&nbsp;Mohamed Ali Siddig Ahmed ,&nbsp;Ovais Wadoo","doi":"10.1016/j.rcsop.2025.100614","DOIUrl":"10.1016/j.rcsop.2025.100614","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 vaccines are known to cause transient changes in white blood cell counts as part of the immune activation process. Clozapine, an antipsychotic agent primarily prescribed for treatment-resistant schizophrenia, possesses both immunosuppressive and pro-inflammatory properties that may influence vaccine-related immune responses. The concurrent use of clozapine during COVID-19 vaccination has therefore raised concerns regarding potential hematological adverse effects. Despite increasing global research in this area, data from Arab populations remain scarce, highlighting the need for region-specific evidence. This study aimed to investigate the incidence of white blood cell and absolute neutrophil count abnormalities in patients receiving clozapine who were vaccinated with mRNA COVID-19 vaccines.</div></div><div><h3>Method</h3><div>A retrospective study was conducted within Qatar's public mental health services. The study included patients on clozapine who received at least one dose of a COVID-19 vaccine between February 2020 and November 2022. Hematological parameters were assessed at three time points: pre-vaccination, shortly post-vaccination, and three months post-vaccination. Demographic, clinical, and vaccine-related factors were also examined.</div></div><div><h3>Results</h3><div>Of 111 vaccinated patients, 74 had complete blood test data across the three time points. No cases of agranulocytosis or other serious hematological adverse effects were observed. Mild leukopenia occurred in 6.8–8.1 % of patients, and mild neutropenia in 5.4–6.8 %. These changes were transient and not associated with clozapine dosage, vaccine type, or other clinical variables.</div></div><div><h3>Conclusion</h3><div>COVID-19 mRNA vaccines appear safe for individuals maintained on clozapine, with only minor, temporary changes in white blood cell counts. These findings support continued vaccination efforts in this population.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"19 ","pages":"Article 100614"},"PeriodicalIF":1.8,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parent perspectives on a pharmacist-disseminated vaping educational tool for vaping prevention 家长对药剂师传播的预防电子烟教育工具的看法
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-15 DOI: 10.1016/j.rcsop.2025.100615
Olufunmilola Abraham , Virginia Quach , Jenny S. Li

Background

Adolescent e-cigarette use is a major public health issue which can lead to respiratory damage and mental health problems. However, there is a lack of reliable educational resources for adolescents and parents. A vaping educational tool can educate parents about e-cigarettes and support discussions with their children. Pharmacists can leverage their accessibility to integrate educating families about vaping within their practice. This study aimed to explore parent perspectives on adolescent vaping, a pharmacist-led vaping educational tool, and pharmacists' potential role in vaping intervention and prevention.

Methods

Parents of adolescents were recruited for virtual semi-structured interviews on vaping knowledge, opinions on pharmacist vaping intervention, and feedback on the Pharmacist-led E-cigarette and Vaping Educational Resource (pH-EVER). Interviews were analyzed on Dedoose software with inductive thematic analysis.

Results

Interviews from 46 parents led to five primary themes: vaping knowledge, exposure, and opinions; pH-EVER availability, feedback and usage; parental and school role in vaping intervention; receptiveness to learning about vaping; and pharmacist role in vaping intervention. Most participants expressed that they had limited vaping knowledge but were aware of some health consequences. Participants found the Ph-EVER to be useful for starting conversations with family. Many participants trusted and respected pharmacists to receive education from them. The Ph-EVER was described as important with potential use to inform and initiate conversations with adolescents on e-cigarette risks.

Conclusion

Parent participants found the Ph-EVER to be a helpful educational tool that can be disseminated in public settings with further need to explore integration into pharmacy practice.
青少年使用电子烟是一个重大的公共卫生问题,可能导致呼吸损伤和精神健康问题。然而,青少年和家长缺乏可靠的教育资源。电子烟教育工具可以教育父母有关电子烟的知识,并支持与孩子进行讨论。药剂师可以利用他们的可及性,在他们的实践中整合对家庭的电子烟教育。本研究旨在探讨家长对青少年电子烟的看法,这是一种药剂师主导的电子烟教育工具,以及药剂师在电子烟干预和预防方面的潜在作用。方法对青少年家长进行虚拟半结构化访谈,内容包括电子烟知识、对药师干预电子烟的意见以及对药师主导的电子烟和电子烟教育资源(pH-EVER)的反馈。在Dedoose软件上对访谈进行归纳主题分析。结果对46名家长的访谈主要涉及5个主题:电子烟知识、接触和观点;pH-EVER的可用性、反馈和使用情况;家长和学校在电子烟干预中的作用;对学习电子烟的接受程度;以及药剂师在电子烟干预中的作用。大多数参与者表示,他们对电子烟的了解有限,但意识到一些健康后果。参与者发现Ph-EVER在与家人开始谈话时很有用。许多参与者信任和尊重药剂师,接受他们的教育。该报告被描述为重要的,具有潜在的用途,可告知并启动与青少年关于电子烟风险的对话。结论家长认为Ph-EVER是一种有益的教育工具,可以在公共环境中推广,但需要进一步探索与药学实践的结合。
{"title":"Parent perspectives on a pharmacist-disseminated vaping educational tool for vaping prevention","authors":"Olufunmilola Abraham ,&nbsp;Virginia Quach ,&nbsp;Jenny S. Li","doi":"10.1016/j.rcsop.2025.100615","DOIUrl":"10.1016/j.rcsop.2025.100615","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent e-cigarette use is a major public health issue which can lead to respiratory damage and mental health problems. However, there is a lack of reliable educational resources for adolescents and parents. A vaping educational tool can educate parents about e-cigarettes and support discussions with their children. Pharmacists can leverage their accessibility to integrate educating families about vaping within their practice. This study aimed to explore parent perspectives on adolescent vaping, a pharmacist-led vaping educational tool, and pharmacists' potential role in vaping intervention and prevention.</div></div><div><h3>Methods</h3><div>Parents of adolescents were recruited for virtual semi-structured interviews on vaping knowledge, opinions on pharmacist vaping intervention, and feedback on the Pharmacist-led <em>E</em>-cigarette and Vaping Educational Resource (pH-EVER). Interviews were analyzed on Dedoose software with inductive thematic analysis.</div></div><div><h3>Results</h3><div>Interviews from 46 parents led to five primary themes: vaping knowledge, exposure, and opinions; pH-EVER availability, feedback and usage; parental and school role in vaping intervention; receptiveness to learning about vaping; and pharmacist role in vaping intervention. Most participants expressed that they had limited vaping knowledge but were aware of some health consequences. Participants found the Ph-EVER to be useful for starting conversations with family. Many participants trusted and respected pharmacists to receive education from them. The Ph-EVER was described as important with potential use to inform and initiate conversations with adolescents on e-cigarette risks.</div></div><div><h3>Conclusion</h3><div>Parent participants found the Ph-EVER to be a helpful educational tool that can be disseminated in public settings with further need to explore integration into pharmacy practice.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"19 ","pages":"Article 100615"},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Let's chat(GPT): Implementation of a ChatGPT-generated social determinants of health activity 让我们聊天(GPT):实现由聊天GPT生成的健康活动的社会决定因素
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-06 DOI: 10.1016/j.rcsop.2024.100553
Karl R. Kodweis, Theodore J. Cory, Elizabeth A. Hall, Christa M. George, Katherine L. March

Background

Artificial intelligence (AI)- powered chatbots have provided some notable benefits for learners. Educators are beginning to explore their possible utility and find ways to leverage AI in their classrooms.

Objective

This study aimed to evaluate the implementation of ChatGPT-generated social determinants of health (SDOH) activity in a team-based pharmacy education course.

Methods

Instructors asked the software to generate a set of learning objectives, an in-class activity, assessment strategies, and summative assessments for a student's conceptual understanding of SDOH. During a required first-year, team-based pharmacy course at the University of Tennessee Health Science Center, participants (n = 95) completed a ChatGPT-generated, in-class activity on SDOH within groups. The students' views on the quality of the activity were evaluated using five Likert-scale questions. Four of the questions assessed the applicability and usefulness of the assignment, with rankings on a scale of 1–4 (1 = strongly disagree; 4 = strongly agree). The fifth question evaluated the quality of the activity compared to activities generated by the instructor, using a scale of 1–5 (1 = far worse; 5 = far better).

Results

For applicability and usefulness,”94.7 % (n = 90) of students agreed that “This in-class exercise was valuable to my professional development as a pharmacist;” 96.8 % (n = 92) agreed with “It is necessary for pharmacists to understand SDOH;” 94.7 % (n = 90) agreement with the statement, “The quality of this in-class activity was on-par with other in-class activities in the course;” and 90.5 % (n = 86) agreed with “This in-class exercise was just as impactful to my professional development as other in-class activities.” The majority of students (63.2 %; n = 60) selected either “somewhat better” (40 %; n = 38) or far better (23.2 %; n = 22) for, “Regarding quality, I feel the in-class activity was ____ than other in-class activities.”

Conclusions

Most students reported that the ChatGPT-generated activity on social determinants of health was useful, applicable, and somewhat or far better than instructor activities. However, AI can generate incorrect information and potentially hinder student learning of conceptual frameworks; thus, instructors should review all output carefully.
人工智能(AI)驱动的聊天机器人为学习者提供了一些显著的好处。教育工作者开始探索人工智能的可能用途,并找到在课堂上利用人工智能的方法。目的本研究旨在评估chatgpt生成的健康社会决定因素(SDOH)活动在团队药学教育课程中的实施情况。方法教师要求软件生成一套学习目标、课堂活动、评估策略和总结性评估,以帮助学生对SDOH的概念理解。在田纳西大学健康科学中心第一年的必修课中,以团队为基础的药学课程,参与者(n = 95)在小组中完成了chatgpt生成的关于SDOH的课堂活动。学生对活动质量的看法使用五个李克特量表问题进行评估。其中四个问题评估了作业的适用性和有用性,评分范围为1 - 4(1 =非常不同意;4 =强烈同意)。第五个问题用1 - 5分(1 =差得多;5 =好多了)。结果在适用性和有用性方面,94.7% (n = 90)的学生同意“该课堂练习对我作为药剂师的专业发展有价值”,96.8% (n = 92)的学生同意“药剂师有必要了解SDOH”,94.7% (n = 90)的学生同意“有必要了解SDOH”。90.5% (n = 86)的人同意“这个课堂练习和其他课堂活动一样,对我的专业发展有同样的影响。”大多数学生(63.2%;N = 60)选择“稍好一些”(40%;N = 38)或更好(23.2%;n = 22),“关于质量,我觉得课堂活动____比其他课堂活动。”大多数学生报告说,chatgpt生成的关于健康的社会决定因素的活动是有用的,适用的,并且在某种程度上或远远优于教师活动。然而,人工智能可能会产生不正确的信息,并可能阻碍学生对概念框架的学习;因此,教师应该仔细检查所有的输出。
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引用次数: 0
Exploring the barriers and facilitators to effective communication with people with age-related hearing loss in community pharmacy settings 探索障碍和促进有效沟通的人与年龄相关的听力损失在社区药房设置
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-06 DOI: 10.1016/j.rcsop.2025.100573
Shanice Thomas , Jane Griffiths , Gabrielle Saunders , Denham Phipps , Chris Todd , Penny Lewis

Background

As populations age, there is a growing number of people who are affected by age-related hearing loss, who are living with chronic health conditions, treated using multiple medicines. Community pharmacy plays an important role in ensuring safe and effective medicine use.

Objective

This study explored the barriers and facilitators to effective communication with people with age-related hearing loss in the community pharmacy setting.

Methods

Semi-structured interviews were conducted with sixteen pharmacy users with self-reported age-related hearing loss in the United Kingdom (UK). Eight community pharmacists took part across two focus groups and one interview. Using a deductive-inductive approach to framework analysis, three overarching themes were generated.

Results

‘Navigating the environment’ highlights barriers related to pharmacists reportedly high workloads and time pressures, also reflected in pharmacy user's accounts. Background noise reduced the confidentiality and effectiveness of communication. Participants had differing views on the extent to which hearing aids could overcome these challenges. ‘Debating the need to communicate and to disclose hearing loss’ reflects barriers relating to pharmacy users' tendency to not disclose their needs, in relation to their personal feelings (embarrassment), perceptions of, and limited contact with, community pharmacy services. Yet, pharmacists emphasised a need to know about hearing loss to adapt communication effectively. Participants reported similar and distinct perspectives regarding ‘coping strategies and solutions to communicate effectively’.

Conclusion

Participants identified a need to improve pharmacists' capacity to implement communication adaptations for people with hearing loss, for which pharmacists suggested digital interventions, and to visibly recognise sensory needs, to promote disclosure.
背景随着人口老龄化,越来越多的人受到与年龄有关的听力损失的影响,他们患有慢性疾病,使用多种药物进行治疗。社区药房在保障安全有效用药方面发挥着重要作用。目的探讨社区药房与年龄相关性听力损失患者有效沟通的障碍和促进因素。方法采用半结构化访谈法对英国16名自报年龄相关性听力损失的药房使用者进行访谈。8名社区药剂师参与了两个焦点小组和一次访谈。使用演绎-归纳方法进行框架分析,产生了三个总体主题。结果“导航环境”突出了与药剂师相关的障碍,据报道,高工作量和时间压力,也反映在药房用户的账户上。背景噪声降低了通信的保密性和有效性。与会者对助听器能在多大程度上克服这些挑战有不同的看法。“讨论沟通和披露听力损失的必要性”反映了与药房使用者倾向于不披露他们的需求有关的障碍,这与他们的个人感受(尴尬)、对社区药房服务的看法和有限的接触有关。然而,药剂师强调有必要了解听力损失,以便有效地适应沟通。参与者报告了关于“有效沟通的应对策略和解决方案”的相似和不同的观点。结论:与会者认为有必要提高药剂师为听力损失患者实施沟通适应的能力,为此药剂师建议进行数字干预,并明显识别感官需求,以促进信息披露。
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引用次数: 0
A qualitative non-participant observational study of non-prescription counseling in community pharmacies 社区药房非处方咨询的定性非参与者观察性研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-05-03 DOI: 10.1016/j.rcsop.2025.100611
Helene Marie Haldorsen Gombos , Tonje Krogstad , Marthe Rambøl Bjørknes , Hege Sletvold , Milada Cvancarova Hagen , Karin Svensberg

Background

The global rise in self-care and non-prescription product sales allows more people to self-treat minor ailments, and pharmacies have a key role in guiding this use. However, discrepancies between counseling standards and practice suggest a gap in ensuring safe and informed self-medication, necessitating exploration and understanding.

Objectives

This study investigates counseling on all non-prescription products in pharmacies, with the following objectives: 1) assess compliance with The Norwegian OTC Counseling Standard (the Standard), 2) identify factors predicting standard compliance, and 3) describe the content of non-prescription counseling.

Methods

A non-participant observation study (n = 275) was conducted in the self-care section of Norwegian pharmacies (n = 7) from September 2022 to March 2023. During the encounters, 494 products were purchased. Notes from the observations were transformed into transcripts. The transcripts were analyzed using Content Analysis, where codes were quantified and compiled into a spreadsheet. Statistical analysis was performed using Chi-square tests and Logistic regression to evaluate standard compliance and predictive factors.

Results

Full compliance with the standard was 14.6 %; however, ∼40 % of product inquiries did not meet the requirements. Busier pharmacies showed higher standard compliance compared to quieter, and counseling starting at the shelves was more comprehensive. Moreover, pharmacists were likelier than pharmacy technicians to provide information about OTC products (p-value = 0.01). Standard compliance was higher for other non-prescription products than for OTC products. Assessment of the customer's product needs typically revolved around previous use, the intended user, and symptoms, with less emphasis on patient-specific factors (e.g., contraindications, interactions). Information was usually practical, for example, instructions on use and dosage, while discussions on effects and adverse drug reactions depended on customer prompts.

Conclusion

The study found infrequent compliance with the standard, with information often being generic and not tailored to customer needs. OTCs have lower standard compliance than other products sold in pharmacies. Further efforts need to be made to improve counseling, including revising the standard focusing on communication skill promotion and expanding to consider all health-related products in the self-care section. This could improve self-treatment and reduce the burden on other healthcare providers.
自我保健和非处方产品销售的全球增长使更多的人能够自我治疗小病,而药房在指导这种使用方面发挥着关键作用。然而,咨询标准与实践之间的差异表明,在确保安全和知情的自我药疗方面存在差距,需要探索和理解。本研究调查了所有非处方药品在药店的咨询情况,目的如下:1)评估挪威OTC咨询标准(该标准)的依从性,2)确定预测标准依从性的因素,3)描述非处方咨询的内容。方法于2022年9月至2023年3月在挪威各药房自我保健科(n = 7)进行非参与式观察研究(n = 275)。在会面期间,共购买了494种产品。观察的笔记被转换成笔录。使用内容分析对转录本进行分析,其中代码被量化并编译成电子表格。采用卡方检验和Logistic回归对标准依从性和预测因素进行统计分析。结果完全符合标准率为14.6%;但是,约40%的产品查询没有达到要求。繁忙的药店比安静的药店更符合标准,从货架上开始的咨询也更全面。此外,药剂师比药学技术人员更有可能提供OTC产品的信息(p值= 0.01)。其他非处方产品的标准符合性高于OTC产品。对客户产品需求的评估通常围绕以前的使用、预期用户和症状展开,较少强调患者特定因素(例如,禁忌症、相互作用)。信息通常是实用的,例如关于使用和剂量的说明,而关于影响和药物不良反应的讨论则取决于顾客的提示。该研究发现,标准的符合性很低,信息通常是通用的,而不是根据客户的需求量身定制的。与药店销售的其他产品相比,otc的标准符合性较低。需要进一步努力来改善咨询,包括修订以沟通技巧提升为重点的标准,并将所有与健康相关的产品扩大到自我保健部分。这可以改善自我治疗,减轻其他医疗保健提供者的负担。
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引用次数: 0
期刊
Exploratory research in clinical and social pharmacy
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