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Examining the evolution and impact of OTC vending machines in Global Healthcare Systems 研究非处方药自动售货机在全球医疗系统中的发展和影响
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-14 DOI: 10.1016/j.rcsop.2024.100540
Ammar Abdulrahman Jairoun , Sabaa Saleh Al-Hemyari , Moyad Shahwan , Sahab Alkhoujah , Faris El-Dahiyat , Ammar Ali Saleh Jaber , Sa'ed H. Zyoud

Background

The study of over the counter (OTC) vending machines is crucial given their growing popularity and potential impact on the pharmaceutical industry and consumer behaviour.

Objectives

This study involves a bibliometric quantitative analysis of academic literature to evaluate OTC vending machines in terms of their evolution, current trends, and potential areas for future research.

Methods and materials

The Scopus database was searched using its advanced search tool, focusing on papers that included the search query in their titles, abstracts, and keywords. Data analysis included bibliometric indicators such as publication counts, citation trends, and co-authorship networks, which were visualized using VOSviewer software (version 1.6.20) to highlight key research themes and collaboration patterns.

Results

A total of 399 publications on OTC vending machines were found between 1833 and 2024. Over the last 20 years, there has been an annual increase in the number of publications related to OTC vending machines, rising from 1 in 2001 to 31 in 2023. The United States (n = 118; 29.57 %) led in productivity, followed by the United Kingdom (45; 11.27 %), India (30; 7.51 %), Australia (27; 6.76 %), Canada (16; 4 %), Italy (15; 3.75 %), and China (15; 3.75 %). A total of 35 institutions have been involved in research on OTC vending machines. The Dubai Municipality contributed the highest percentage of articles (n = 3, 0.75 %), followed by the Emirates Health Services (n = 3, 0.75 %), Al Ain University (n = 2, 0.5 %), and Baystate Medical Center (n = 2, 0.5 %). Before 2016, much of the research on OTC vending machines focused on terms related to healthcare policy and health promotion, indicating the early exploration of this field. Present trends highlight terms associated with pharmacy practice, such as pharmacists, pharmacy, and prescription-related subjects.

Conclusions

This study emphasises the practical necessity for enhanced regulatory structures to mitigate risks such as medication abuse, unfavourable drug interactions, and incorrect dispensing practices. Additionally, the study highlights the need for interdisciplinary collaboration among technologists, policymakers, and healthcare professionals to maximize the benefits of OTC vending machines while addressing consumer behaviour and safety issues.
背景鉴于非处方药(OTC)自动售货机的日益普及及其对制药行业和消费者行为的潜在影响,对其进行研究至关重要。本研究对学术文献进行了文献计量学定量分析,以评估非处方药自动售货机的演变、当前趋势以及未来研究的潜在领域。数据分析包括文献计量指标,如发表数量、引用趋势和合著网络,并使用 VOSviewer 软件(1.6.20 版)对这些指标进行可视化,以突出关键研究主题和合作模式。在过去 20 年中,与非处方药自动售货机相关的出版物数量逐年增加,从 2001 年的 1 篇增加到 2023 年的 31 篇。美国(n = 118; 29.57 %)的产量居首位,其次是英国(45; 11.27 %)、印度(30; 7.51 %)、澳大利亚(27; 6.76 %)、加拿大(16; 4 %)、意大利(15; 3.75 %)和中国(15; 3.75 %)。共有 35 个机构参与了非处方药自动售货机的研究。迪拜市政府撰写的文章比例最高(3 篇,0.75%),其次是阿联酋卫生服务机构(3 篇,0.75%)、艾因大学(2 篇,0.5%)和贝州医疗中心(2 篇,0.5%)。在 2016 年之前,有关非处方药自动售货机的研究大多集中在与医疗保健政策和健康促进相关的术语上,这表明了这一领域的早期探索。目前的趋势突出了与药学实践相关的术语,如药剂师、药房和与处方相关的主题。结论本研究强调了加强监管结构以降低药物滥用、不利的药物相互作用和不正确的配药实践等风险的实际必要性。此外,该研究还强调了技术专家、政策制定者和医疗保健专业人员之间开展跨学科合作的必要性,以便在解决消费者行为和安全问题的同时,最大限度地发挥非处方药自动售货机的优势。
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引用次数: 0
Screening and referral programs for diabetes and cardiovascular disease: Can community pharmacists bridge the care gap? 糖尿病和心血管疾病的筛查和转诊项目:社区药剂师能否弥合护理差距?
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-13 DOI: 10.1016/j.rcsop.2024.100539
Melanie Livet , Amber Watson , Shweta Pathak , Courtney Humphries , Jessica Roller , Jon Easter

Background and Objectives

Heart disease and diabetes are leading causes of death in the U.S., with timely screening, referrals, and education being critical for effective treatment. The Community-based Valued-driven Care Initiative (CVCI) aimed to develop, implement, and evaluate the feasibility of delivering patient-centered care interventions for high priority disease states in community pharmacies. This article focuses specifically on two of the selected interventions, both of which were screening and referral (S&R) programs for the prevention and treatment of cardiovascular disease (CVD) and diabetes (DM) respectively. This exploratory evaluation was designed as an effectiveness-implementation hybrid Type II study. Its objectives were to assess both implementation and preliminary program effectiveness using mixed data.

Methods

Fifteen community pharmacies opted to implement one of the two programs over a 12-month period. Implementation feasibility involved examining program adoption rates by sites and patients; acceptability, appropriateness, feasibility, and intent to sustain use survey scores; and pharmacists' interviews. Program effectiveness was based on patient referral rates, physician follow-up communication rates, and perceived outcomes, collected via patient logs, surveys, and interviews.

Results

Two of the 15 sites discontinued participation, yielding an 87 % adoption rate. Patient adoption varied based on contact and screening rates, due to differences in patient recruitment, staffing, and workflow. Pharmacist acceptability, compatibility, and feasibility remained high throughout implementation; however, only three pharmacy sites planned on continuing offering the programs. All at-risk patients were appropriately referred based on screening results, with 65 % having their screening results communicated to their primary healthcare providers. The programs were perceived as beneficial, increasing pharmacists' knowledge and motivation, enhancing relationships with patients, and producing an impact on patients'' health.

Discussion

Results highlight the implementation feasibility and preliminary outcomes of delivering DM and CVD S&R programs in community pharmacies. However, despite these positive results, most pharmacies did not intend to continue the programs, underscoring the continued need for sustainable clinical services models in non-traditional settings. Success with broader implementation will require a paradigm shift in support of community pharmacists as clinical care extenders.
背景与目的在美国,心脏病和糖尿病是导致死亡的主要原因,及时筛查、转诊和教育是有效治疗的关键。基于社区的价值驱动型护理倡议(CVCI)旨在开发、实施和评估在社区药房为高优先疾病状态提供以患者为中心的护理干预措施的可行性。本文特别关注其中两种选定的干预措施,这两种干预措施分别是预防和治疗心血管疾病(CVD)和糖尿病(DM)的筛查和转诊(S&;R)计划。本探索性评价设计为有效性-实施混合型II型研究。其目的是使用混合数据评估实施和初步方案的有效性。方法15家社区药店选择在12个月的时间内实施两种方案中的一种。实施可行性包括检查项目的地点和患者的采用率;可接受性、适当性、可行性和意图维持使用调查得分;还有药剂师的采访。项目的有效性基于患者转诊率、医生随访沟通率和感知结果,这些数据通过患者日志、调查和访谈收集。结果15个站点中有2个停止参与,采用率为87%。由于患者招募、人员配备和工作流程的差异,患者采用率因接触率和筛查率而异。在整个实施过程中,药师的可接受性、兼容性和可行性保持较高;然而,只有三家药店计划继续提供这项服务。根据筛查结果,所有高危患者都得到了适当的转诊,65%的患者将筛查结果告知了初级卫生保健提供者。这些项目被认为是有益的,增加了药剂师的知识和动力,加强了与患者的关系,并对患者的健康产生了影响。讨论结果强调了在社区药房实施DM和CVD s&s&r项目的可行性和初步成果。然而,尽管取得了这些积极的成果,大多数药店并不打算继续实施这些计划,这强调了在非传统环境中持续需要可持续的临床服务模式。成功的更广泛的实施将需要一个范例的转变,以支持社区药剂师作为临床护理的推动者。
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引用次数: 0
A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists 苯并二氮杂卓受体激动剂机动车驾驶员性能评估范围审查
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-09 DOI: 10.1016/j.rcsop.2024.100538
Andrea L. Murphy , Korolos Sawires , Sophie M. Peltekian , Melissa Helwig , Marilyn Macdonald , Ruth Martin-Misener , Bandana Saini , Heather Neyedli , Chris Giacomantonio , David M. Gardner

Background

Benzodiazepines and Z-drugs (e.g., zopiclone, zolpidem) (benzodiazepine receptor agonists or BZRAs), are prescribed for anxiety and insomnia disorders. However, they are not indicated as first line therapies for long-term management due to harms and efficacy limitations. BZRAs have also been associated with traffic accident risks. Patients taking BZRAs are told to consult with health care providers regarding motor vehicle operation safety. However, advice on driving is variable. The objective of this scoping review is to identify, map, and characterize the evidence for assessments that measure driving performance in people taking BZRAs.

Methods

Embase (Elsevier), MEDLINE (Ovid), and PsycINFO (EBSCO) were searched. Covidence was used for screening. Each stage of screening included two independent reviewers. A REDCap database was used for data extraction by two independent reviewers. Results were tabulated and summarised as a narrative.

Results

Driving performance was assessed with 20 unique BZRAs across 183 studies (n = 92 experimental; n = 91 observational) in 178 publications. Zopiclone was the most studied. In experimental studies, the Standard Deviation of Lateral Position (SDLP) was used most often (n = 54, 62 %) and many studies (n = 35, 38 %) were conducted in the Netherlands. For observational studies, biological detection (e.g., urine, blood) (n = 73, 80 %) followed by prescription drug/dispensing records (n = 17, 19 %) were the most common impairment measures and Norway (n = 20) is where most studies took place. In experimental studies, most (n = 89, 97 %) were conducted using only one driving setting. Simulated driving in a car (n = 36) and road driving in traffic (n = 36) were common as compared to nontraffic driving course (n = 8) and simulated driving (n = 9). In experimental studies, seventy-eight of the 92 studies (85 %) had at least one measure that identified impairment.

Conclusions

BZRA effects on motor vehicle driving performance have been studied using heterogenous protocols with multiple measures and settings, ranging from simulation to authentic traffic situations in experimental studies to biological detection and dispensing records in observational studies. Many BZRAs have been studied but study representation does not match prescribing pattern prevalence. The interpretation and contextualization of results for clinical practice is challenging due to the complexity (i.e., protocols, measures, settings). Future work in this area should work to improve knowledge translation of results so information is more readily accessible and applicable to health care providers and patients.
背景苯二氮卓类药物和 Z 类药物(如佐匹克隆、唑吡坦)(苯二氮卓受体激动剂或 BZRA)可用于治疗焦虑症和失眠症。然而,由于其危害性和疗效的局限性,它们并不适合作为长期治疗的一线疗法。BZRAs 还与交通事故风险有关。服用 BZRAs 的患者被告知应向医护人员咨询有关机动车驾驶安全的问题。然而,有关驾驶的建议不尽相同。本范围综述的目的是识别、绘制和描述评估服用 BZRAs 患者驾驶性能的证据。使用 Covidence 进行筛选。每个筛选阶段都有两名独立审稿人。两名独立审稿人使用 REDCap 数据库进行数据提取。结果在 178 篇出版物的 183 项研究(n = 92 项实验研究;n = 91 项观察研究)中使用 20 种独特的 BZRA 对驾驶性能进行了评估。研究最多的是佐匹克隆。在实验研究中,最常使用的是侧位标准偏差(SDLP)(n = 54,62%),许多研究(n = 35,38%)在荷兰进行。在观察性研究中,生物检测(如尿液、血液)(n = 73,80%)是最常用的损伤测量方法,其次是处方药/配药记录(n = 17,19%),挪威(n = 20)是大多数研究的发生地。在实验研究中,大多数研究(n = 89,97%)只使用一种驾驶环境。与非交通驾驶课程(8 项)和模拟驾驶(9 项)相比,汽车模拟驾驶(36 项)和交通道路驾驶(36 项)更为常见。在实验研究中,92 项研究中有 78 项(85%)至少有一种测量方法可确定损伤。结论BZRA 对机动车驾驶性能影响的研究采用了多种测量方法和设置的不同方案,从实验研究中的模拟真实交通状况到观察研究中的生物检测和配药记录。对许多 BZRA 进行了研究,但研究的代表性与处方模式的普遍性并不匹配。由于其复杂性(即协议、措施、设置),对临床实践结果的解释和上下文关联具有挑战性。该领域未来的工作应致力于改善结果的知识转化,使信息更易于获取,并适用于医疗服务提供者和患者。
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引用次数: 0
High-risk medication errors: Insight from the UK National Reporting and learning system 高风险用药错误:英国国家报告和学习系统的启示。
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-04 DOI: 10.1016/j.rcsop.2024.100531
Abdulrhman Alrowily , Khalid Alfaraidy , Saleh Almutairi , Abdullah Alamri , Wejdan Alrowily , Mohammed Abutaleb , Mohammad Zaitoun , Waddad Sarawi , Mashael Aljead

Background

Ensuring patient safety is of paramount importance in healthcare systems. Rising concerns about medical errors in the UK have necessitated a greater focus on studying the nature of such errors, particularly those involving high-risk medications.

Objectives

To conduct a retrospective analysis of incidents related to patient safety in the UK based on data from the National Rporting and Learning System (NRLS).

Methods

This study was conducted based on a review of the National Reporting and Learning System (NRLS) patient safety reports published between January 1, 2015, and December 31, 2015. NHS Improvement provides details regarding incidents following approval using a data-sharing agreement. In total, 1500 incidents were analszed and equally divided among the three categories of high-risk drugs: opioids, insulin, and anticoagulants. Excel® features and deductive reasoning (thematic analysis) were used for data analysis.

Results

The results showed that the insulin category had both the highest risk and most errors compared with anticoagulants and opioids. These errors primarily result from issues related to administering, prescribing, and dispensing the drugs. Inadequate drug checks, communication difficulties among staff and patients, and high staff workloads are often linked to these errors.

Conclusion

This study confirms that the NRLS database is a valuable source of data, and the suggestions put forth, based on these results, could contribute to the formulation of measures that diminish the occurrence of errors related to high-risk drugs in healthcare settings. Information technology should enhance medication safety by tracking the process of medication use.
背景:在医疗保健系统中,确保患者安全至关重要。在英国,人们对医疗差错的担忧日益增加,这就需要更多地关注研究此类差错的性质,特别是那些涉及高风险药物的差错。目的:根据国家报告和学习系统(NRLS)的数据,对英国与患者安全相关的事件进行回顾性分析。方法:本研究基于2015年1月1日至2015年12月31日期间发布的国家报告和学习系统(NRLS)患者安全报告进行。NHS改进使用数据共享协议提供有关批准后事件的详细信息。总共分析了1500起事件,并将其平均分为三类高危药物:阿片类药物、胰岛素和抗凝血剂。使用Excel®功能和演绎推理(主题分析)进行数据分析。结果:与抗凝剂和阿片类药物相比,胰岛素类别的风险最高,错误也最多。这些错误主要是由于与给药、处方和配药有关的问题造成的。药物检查不足、工作人员和患者之间的沟通困难以及工作人员工作量大往往与这些错误有关。结论:本研究证实NRLS数据库是一个有价值的数据来源,基于这些结果提出的建议有助于制定措施,减少医疗机构中高危药物相关错误的发生。信息技术应该通过跟踪用药过程来加强用药安全。
{"title":"High-risk medication errors: Insight from the UK National Reporting and learning system","authors":"Abdulrhman Alrowily ,&nbsp;Khalid Alfaraidy ,&nbsp;Saleh Almutairi ,&nbsp;Abdullah Alamri ,&nbsp;Wejdan Alrowily ,&nbsp;Mohammed Abutaleb ,&nbsp;Mohammad Zaitoun ,&nbsp;Waddad Sarawi ,&nbsp;Mashael Aljead","doi":"10.1016/j.rcsop.2024.100531","DOIUrl":"10.1016/j.rcsop.2024.100531","url":null,"abstract":"<div><h3>Background</h3><div>Ensuring patient safety is of paramount importance in healthcare systems. Rising concerns about medical errors in the UK have necessitated a greater focus on studying the nature of such errors, particularly those involving high-risk medications.</div></div><div><h3>Objectives</h3><div>To conduct a retrospective analysis of incidents related to patient safety in the UK based on data from the National Rporting and Learning System (NRLS).</div></div><div><h3>Methods</h3><div>This study was conducted based on a review of the National Reporting and Learning System <strong>(</strong>NRLS) patient safety reports published between January 1, 2015, and December 31, 2015. NHS Improvement provides details regarding incidents following approval using a data-sharing agreement. In total, 1500 incidents were analszed and equally divided among the three categories of high-risk drugs: opioids, insulin, and anticoagulants. Excel® features and deductive reasoning (thematic analysis) were used for data analysis.</div></div><div><h3>Results</h3><div>The results showed that the insulin category had both the highest risk and most errors compared with anticoagulants and opioids. These errors primarily result from issues related to administering, prescribing, and dispensing the drugs. Inadequate drug checks, communication difficulties among staff and patients, and high staff workloads are often linked to these errors.</div></div><div><h3>Conclusion</h3><div>This study confirms that the NRLS database is a valuable source of data, and the suggestions put forth, based on these results, could contribute to the formulation of measures that diminish the occurrence of errors related to high-risk drugs in healthcare settings. Information technology should enhance medication safety by tracking the process of medication use.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"17 ","pages":"Article 100531"},"PeriodicalIF":1.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empowering Thai community pharmacists in combating antimicrobial resistance: Qualitative insight and sentiment analysis 增强泰国社区药剂师抗击抗生素耐药性的能力:定性洞察与情感分析
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-03 DOI: 10.1016/j.rcsop.2024.100535
Rojjares Netthong , Sisira Donsamak , Dai N. John , Ros Kane , Keivan Armani

Background

Antimicrobial resistance (AMR) is increasing globally and poses a significant public health challenge. Community pharmacists, especially in primary care settings, play a pivotal role in mitigating the irrational use of antibiotics, a key driver of AMR.

Objectives

This study aims to explore qualitative insights from community pharmacists regarding antibiotic supply and usage, analyze sentiments related to AMR, and highlight the crucial role of community pharmacists in AMR stewardship at the primary care/community level.

Methods

This study engaged community pharmacists in Thailand through semi-structured interviews to obtain in-depth insights into the antibiotic supply and perceptions of AMR. Additionally, sentiment analysis, which evaluates the emotional tone of the pharmacists' responses, was conducted to enrich the findings.

Results

Interviews with 23 community pharmacists highlighted the practices, challenges, and strategies related to antibiotic supply and use. Key findings include the identification of barriers such as patient demand and lack of awareness about antimicrobial resistance (AMR), alongside strategies for improvement such as public education and professional development. Sentiment analysis reveals a cautiously optimistic perspective toward enhancing rational antibiotic use, underscoring the importance of comprehensive approaches that combine education, ethics, and regulatory measures to address the complexities of antibiotic management at community pharmacies.

Conclusion

This study underscores the necessity of public awareness, pharmacist–patient relationships, and regulatory reforms for the rational use of antibiotics in community pharmacies. These findings emphasize that pharmacist education and adherence to professional ethics are essential for mitigating antimicrobial resistance and promoting rational antibiotic use.
背景抗生素耐药性(AMR)在全球范围内日益严重,对公共卫生构成了巨大挑战。本研究旨在探讨社区药剂师对抗生素供应和使用的定性见解,分析与 AMR 相关的情绪,并强调社区药剂师在初级保健/社区层面的 AMR 管理中的关键作用。方法本研究通过半结构式访谈的方式,与泰国的社区药剂师接触,深入了解抗生素供应情况和对 AMR 的看法。此外,还进行了情感分析,评估药剂师回答中的情感基调,以丰富研究结果。结果对 23 名社区药剂师的访谈强调了与抗生素供应和使用相关的实践、挑战和策略。主要发现包括患者需求和缺乏对抗菌药耐药性 (AMR) 的认识等障碍,以及公众教育和专业发展等改进策略。情感分析表明,人们对加强合理使用抗生素持谨慎乐观的态度,强调了结合教育、道德和监管措施的综合方法的重要性,以解决社区药房抗生素管理的复杂性。这些发现强调,药剂师教育和遵守职业道德对于减轻抗菌素耐药性和促进合理使用抗生素至关重要。
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引用次数: 0
Deprescribing oral antidiabetics in elderly patients: Do electronic leaflets across the world address it? 老年患者口服抗糖尿病药物的处方减少:世界各地的电子宣传单是否解决了这一问题?
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-11-01 DOI: 10.1016/j.rcsop.2024.100537
Kitete Tunda Bunnel, Silvio José Elisei Carvalho Jr, Mariana Linhares Pereira, Renê Oliveira Couto, André Oliveira Baldoni
Diabetes caused 6.7 million deaths in 2021, equating to one death every five seconds, with its global financial burden projected to rise from $1.32 trillion in 2015 to $2.12 trillion by 2030. Severe hypoglycemia necessitates interventions like deprescribing, behavioral strategies, and technology for prevention. Deprescribing aims to reduce unnecessary medication use, enhance rational prescribing, prevent prescribing cascades, and improve health outcomes in elderly patients. Evaluating electronic leaflets can support deprescribing based on patient-centered care and shared decision-making.

Objective

To analyze information on deprescribing in oral antidiabetic leaflets from national medicines regulatory authorities, focusing on elderly patients with type 2 diabetes.

Methods

This documental study analyzed electronic leaflets of oral antidiabetics from the official websites of nine Medicines Regulatory Authorities: Australia, Brazil, Canada, New Zealand, Singapore, South Africa, UK, USA, and EU, covering drugs listed in the WHO's Essential Medicines List 2023. The analysis focused on the alignment of deprescribing information with the Ontario deprescribing algorithm for oral antidiabetics developed by the Bruyère Institute in Canada.

Results

Out of 72 expected leaflets, 64 (88.9 %) were retrieved. Only 18 leaflets (28.1 %) explicitly discussed deprescribing oral antihyperglycemics. Hypoglycemia and drug interaction risks were addressed in 55 leaflets (85.9 %). Caution for use in patients over 65 was mentioned in 32 leaflets (50 %), and 23 leaflets (35.9 %) addressed the risks of tight glucose and HbA1c targets.

Conclusion

Despite a high retrieval rate, 11.1 % of leaflets were missing, and those available contained inconsistent deprescribing information. There are significant disparities in guidance across regulatory authorities. Standardized, updated leaflets that address deprescribing in frail older patients could enhance prescribers' confidence and support shared decision-making
2021 年,糖尿病导致 670 万人死亡,相当于每 5 秒钟就有一人死亡,其全球经济负担预计将从 2015 年的 1.32 万亿美元增至 2030 年的 2.12 万亿美元。严重低血糖需要采取干预措施,如取消处方、行为策略和技术预防。取消处方旨在减少不必要的用药,提高处方的合理性,防止处方连环效应,改善老年患者的健康状况。评估电子宣传页可支持基于以患者为中心的护理和共同决策的去处方化。目的分析各国药品监管机构提供的口服抗糖尿病药物宣传页中有关去处方化的信息,重点关注 2 型糖尿病老年患者:澳大利亚、巴西、加拿大、新西兰、新加坡、南非、英国、美国和欧盟九个药品监管局的官方网站上的口服抗糖尿病药物电子说明书进行了分析,涵盖了世界卫生组织《2023 年基本药物目录》中列出的药物。分析的重点是处方信息与加拿大布鲁耶尔研究所开发的安大略省口服抗糖尿病药处方算法的一致性。只有 18 份宣传单(28.1%)明确讨论了口服降糖药的停药问题。55 份宣传页(85.9%)涉及低血糖和药物相互作用风险。尽管检索率很高,但仍有 11.1% 的宣传单张丢失,而且现有宣传单张中的处方信息也不一致。各监管机构在指导方面存在很大差异。针对老年体弱患者去处方化问题的标准化最新宣传单可增强处方者的信心并支持共同决策。
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引用次数: 0
Impact of pharmacist-led interventions in identifying and resolving drug related problems and potentially inappropriate prescriptions among rural patients: A pilot study 以药剂师为主导的干预措施在识别和解决农村患者药物相关问题及潜在不当处方方面的影响:试点研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-10-24 DOI: 10.1016/j.rcsop.2024.100536
Salvador Gutiérrez-Igual , Rut Lucas-Domínguez , José Sendra-Lillo , Alberto Martí-Rodrigo , Isabel Romero Crespo , M. Carmen Montesinos

Background

Drug-related problems are a major problem that can lead to increased morbidity, mortality, and healthcare costs due to heightened medical visits, hospital readmissions, or emergency room visits. In rural areas, new tools for clinical pharmacy services, such as medication review, could decrease this problem.

Objective

To analyze the prevalence of clinically relevant drug-related problems (DRPs) and potentially inappropriate prescriptions (PIPs) identified by new medication review software (Revisem®) in rural pharmacies. The effectiveness of resolving DRPs and PIPs in patients who received pharmacist-led intervention (PLI) was also evaluated.

Methods

A prospective, multicenter, observational pilot study in 17 rural pharmacies from the Valencian region (Spain) was conducted over a period of 6 months. Revisem®, a type 1 medication review software, was developed and implemented to detect and resolve drug-related issues (DRPs and PIPs). The clinical history of 135 polymedicated patients was recorded, as well as the PLI conducted after the identification of incidences. The mean number of DRPs and PIPs before and after PLI were analyzed and compared.

Findings

A total of 1545 drug-related issues were detected in 135 patients (86 women). 1166 were DRPs and 379 were PIPs. Interactions were the most common incidence (43.7 %), with furosemide and omeprazole being the drugs with the highest number of significant interactions. In the before-after intervention study, the mean number of incidents detected per patient by Revisem® decreased from 9.7 ± 6.9 to 8.8 ± 6.9 (p < 0.05) after PLI. Written reports were the most frequent means of communication between pharmacists and physicians (45.0 %). The acceptance rate of pharmacists' suggestions was 45.2 %.

Conclusion

The impact of pharmacist-led interventions in rural pharmacies allowed the detection of a high number of drug-related issues and significantly reduced the number of DRPs and PIPs, preventing negative health outcomes.
背景药物相关问题是一个重大问题,可导致发病率、死亡率和医疗费用增加,原因是就诊人数、再次入院人数或急诊就诊人数增加。目的 分析农村药房使用新型药物审查软件 (Revisem®) 发现的临床相关药物问题 (DRP) 和潜在不当处方 (PIP) 的发生率。方法 在巴伦西亚地区(西班牙)的 17 家农村药房开展了一项为期 6 个月的前瞻性、多中心、观察性试点研究。Revisem® 是一款 1 类药物审查软件,用于检测和解决与药物相关的问题(DRP 和 PIP)。记录了 135 名多药患者的临床病史,以及发现问题后进行的 PLI。对 PLI 前后的 DRP 和 PIP 平均数量进行了分析和比较。其中 1166 例为 DRP,379 例为 PIP。相互作用是最常见的情况(43.7%),其中呋塞米和奥美拉唑是发生重大相互作用次数最多的药物。在干预前后的研究中,PLI 后,Revisem® 检测到的每位患者的平均事件数从 9.7 ± 6.9 降至 8.8 ± 6.9(p <0.05)。书面报告是药剂师和医生之间最常见的沟通方式(45.0%)。药剂师建议的接受率为 45.2%。结论药剂师主导的干预措施对农村药房的影响是发现了大量与药物相关的问题,显著减少了 DRP 和 PIP 的数量,避免了负面的健康后果。
{"title":"Impact of pharmacist-led interventions in identifying and resolving drug related problems and potentially inappropriate prescriptions among rural patients: A pilot study","authors":"Salvador Gutiérrez-Igual ,&nbsp;Rut Lucas-Domínguez ,&nbsp;José Sendra-Lillo ,&nbsp;Alberto Martí-Rodrigo ,&nbsp;Isabel Romero Crespo ,&nbsp;M. Carmen Montesinos","doi":"10.1016/j.rcsop.2024.100536","DOIUrl":"10.1016/j.rcsop.2024.100536","url":null,"abstract":"<div><h3>Background</h3><div>Drug-related problems are a major problem that can lead to increased morbidity, mortality, and healthcare costs due to heightened medical visits, hospital readmissions, or emergency room visits. In rural areas, new tools for clinical pharmacy services, such as medication review, could decrease this problem.</div></div><div><h3>Objective</h3><div>To analyze the prevalence of clinically relevant drug-related problems (DRPs) and potentially inappropriate prescriptions (PIPs) identified by new medication review software (Revisem®) in rural pharmacies. The effectiveness of resolving DRPs and PIPs in patients who received pharmacist-led intervention (PLI) was also evaluated.</div></div><div><h3>Methods</h3><div>A prospective, multicenter, observational pilot study in 17 rural pharmacies from the Valencian region (Spain) was conducted over a period of 6 months. Revisem®, a type 1 medication review software, was developed and implemented to detect and resolve drug-related issues (DRPs and PIPs). The clinical history of 135 polymedicated patients was recorded, as well as the PLI conducted after the identification of incidences. The mean number of DRPs and PIPs before and after PLI were analyzed and compared.</div></div><div><h3>Findings</h3><div>A total of 1545 drug-related issues were detected in 135 patients (86 women). 1166 were DRPs and 379 were PIPs. Interactions were the most common incidence (43.7 %), with furosemide and omeprazole being the drugs with the highest number of significant interactions. In the before-after intervention study, the mean number of incidents detected per patient by Revisem® decreased from 9.7 ± 6.9 to 8.8 ± 6.9 (<em>p</em> &lt; 0.05) after PLI. Written reports were the most frequent means of communication between pharmacists and physicians (45.0 %). The acceptance rate of pharmacists' suggestions was 45.2 %.</div></div><div><h3>Conclusion</h3><div>The impact of pharmacist-led interventions in rural pharmacies allowed the detection of a high number of drug-related issues and significantly reduced the number of DRPs and PIPs, preventing negative health outcomes.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100536"},"PeriodicalIF":1.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professional pharmacy Services' outcomes performance measurement: A narrative review 专业药房服务的成果绩效衡量:叙述性综述
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-10-23 DOI: 10.1016/j.rcsop.2024.100533
Lígia Reis , João Gregório

Background

Professional pharmacy services are widely recognized for their role in promoting patient health and ensuring optimal medication therapy outcomes. Community pharmacies and pharmacists need to assess professional services' performance at patient level and demonstrate their value to stakeholders. To do so is important to understand which outcome performance indicators are currently being used and how added value is proven.

Objective

To identify performance indicators that measure patients' outcomes and demonstrate value of professional pharmacy services.

Methods

A narrative review was performed based on a systematic search in Pubmed and Scopus databases since year 2000. Manually search was also conducted in Google Scholar and Google.com. Inclusion criteria followed the PCC mnemonic in which Population is “community pharmacies”, Context is “pharmaceutical care, professional pharmaceutical services or pharmaceutical interventions” and Concept is “key performance indicators, or performance measures or clinical indicators”. English, Spanish or Portuguese language were accepted.

Results

All types of papers were included, adding up to a total of 12 papers. The publication of papers on this subject has increased in the last decade. Outcomes indicators identified were based in different frameworks, mainly linked to quality, and were clearly outlined. Disease and therapy management were the most evaluated services. Indicators were identified across 8 different domains corresponding, predominantly, to outputs rather than outcomes. Measurement is mainly conducted under the auspices of coalitions, alliances, government and payers reflecting their perspectives and based on easy-to-retrieve pharmacy data and information.

Conclusions

A paradigm shift is needed, so that performance indicators are based on more appropriate frameworks to measure patient level outcomes and value assignment of professional pharmacy services. By providing robust evidence of the impact of pharmacist interventions on patient outcomes, community pharmacists can advocate for the integration, expansion, and recognition of pharmacist-led services within the broader healthcare system.
背景专业药学服务在促进患者健康和确保最佳药物治疗效果方面的作用得到了广泛认可。社区药房和药剂师需要评估专业服务在患者层面的表现,并向利益相关者展示其价值。为此,了解目前正在使用哪些结果绩效指标以及如何证明其附加值非常重要。方法根据自 2000 年以来在 Pubmed 和 Scopus 数据库中的系统性搜索,进行了叙述性综述。还在 Google Scholar 和 Google.com 上进行了手动搜索。纳入标准采用 PCC 记忆法,其中 Population 指 "社区药房",Context 指 "医药护理、专业医药服务或医药干预",Concept 指 "关键绩效指标、绩效衡量或临床指标"。结果 所有类型的论文均被收录,共计 12 篇。在过去十年中,有关这一主题的论文发表量有所增加。所确定的成果指标基于不同的框架,主要与质量相关,并有明确的概述。疾病和治疗管理是接受评估最多的服务。已确定的指标涉及 8 个不同领域,主要与产出而非成果相关。衡量工作主要在联盟、政府和支付方的支持下进行,反映了他们的观点,并以易于检索的药学数据和信息为基础。通过提供药剂师干预措施对患者疗效影响的有力证据,社区药剂师可以倡导在更广泛的医疗保健系统中整合、扩大和认可药剂师主导的服务。
{"title":"Professional pharmacy Services' outcomes performance measurement: A narrative review","authors":"Lígia Reis ,&nbsp;João Gregório","doi":"10.1016/j.rcsop.2024.100533","DOIUrl":"10.1016/j.rcsop.2024.100533","url":null,"abstract":"<div><h3>Background</h3><div>Professional pharmacy services are widely recognized for their role in promoting patient health and ensuring optimal medication therapy outcomes. Community pharmacies and pharmacists need to assess professional services' performance at patient level and demonstrate their value to stakeholders. To do so is important to understand which outcome performance indicators are currently being used and how added value is proven.</div></div><div><h3>Objective</h3><div>To identify performance indicators that measure patients' outcomes and demonstrate value of professional pharmacy services.</div></div><div><h3>Methods</h3><div>A narrative review was performed based on a systematic search in Pubmed and Scopus databases since year 2000. Manually search was also conducted in Google Scholar and <span><span>Google.com</span><svg><path></path></svg></span>. Inclusion criteria followed the PCC mnemonic in which Population is “community pharmacies”, Context is “pharmaceutical care, professional pharmaceutical services or pharmaceutical interventions” and Concept is “key performance indicators, or performance measures or clinical indicators”. English, Spanish or Portuguese language were accepted.</div></div><div><h3>Results</h3><div>All types of papers were included, adding up to a total of 12 papers. The publication of papers on this subject has increased in the last decade. Outcomes indicators identified were based in different frameworks, mainly linked to quality, and were clearly outlined. Disease and therapy management were the most evaluated services. Indicators were identified across 8 different domains corresponding, predominantly, to outputs rather than outcomes. Measurement is mainly conducted under the auspices of coalitions, alliances, government and payers reflecting their perspectives and based on easy-to-retrieve pharmacy data and information.</div></div><div><h3>Conclusions</h3><div>A paradigm shift is needed, so that performance indicators are based on more appropriate frameworks to measure patient level outcomes and value assignment of professional pharmacy services. By providing robust evidence of the impact of pharmacist interventions on patient outcomes, community pharmacists can advocate for the integration, expansion, and recognition of pharmacist-led services within the broader healthcare system.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100533"},"PeriodicalIF":1.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ReflACTION framework: A proposed model for implementation of clinical pharmacy services ReflACTION 框架:临床药学服务的拟议实施模式
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-10-22 DOI: 10.1016/j.rcsop.2024.100534
Kérilin Stancine Santos Rocha , Sabrina Cerqueira-Santos , Genival Araújo dos Santos-Júnior , Lincoln Marques Cavalcante-Santos , Fernando de Castro Araújo-Neto , Fernanda Oliveira Prado , Giselle de Carvalho Brito , Divaldo Pereira de Lyra-Jr.
The implementation of clinical pharmacy services (CPS) has grown worldwide. However, few studies have used models and/or frameworks to facilitate the implementation process, especially in a low and middle-income countries. In addition, there are limitations in the ways that implementation frameworks are used. Therefore, this discussion aimed to propose and describe an approach using the ReflACTION framework. ReflACTION emerged from several years of systematic observation and experience of the Laboratory of Teaching and Research in Social Pharmacy (LEPFS) in implementing CPS in different settings of Brazilian health system. These experiences led the research group to systematize the implementation of CPS based on three theorical references: Paulo Freire's theoretical references, the Maguerez Arc and the Apoteca framework. The ReflACTION framework proposes five steps that starts and ends in the setting, which are: observation of reality; gathering key-points; theorization; solution hypothesis; and application to reality. All steps were carried out considering the determinants of the implementation process. For the present study, we highlight the importance of the implementation team, the involvement of stakeholders as well as their dialogue and awareness. Thus, we describe the operationalization process for each step. The ReflACTION framework can be used to describe and guide the implementation process of CPS. We expect the proposed framework may add knowledge to implementation science and, ultimately, achieve desired patient outcomes.
临床药学服务(CPS)的实施已在全球范围内得到发展。然而,很少有研究使用模型和/或框架来促进实施过程,尤其是在中低收入国家。此外,实施框架的使用方式也存在局限性。因此,本次讨论旨在提出并描述一种使用 ReflACTION 框架的方法。ReflACTION 是社会药学教学与研究实验室(LEPFS)在巴西卫生系统的不同环境中实施 CPS 的数年系统观察和经验的结晶。这些经验促使研究小组在三个理论参考的基础上将 CPS 的实施系统化:保罗-弗莱雷(Paulo Freire)的理论参考、马奎雷斯弧线(Maguerez Arc)和 Apoteca 框架。ReflACTION 框架提出了以环境为起点和终点的五个步骤,即:观察现实;收集关键点; 理论化;解决方案假设;以及应用于现实。所有步骤的实施都考虑到了实施过程的决定因素。在本研究中,我们强调实施团队、利益相关者的参与以及他们的对话和认识的重要性。因此,我们描述了每个步骤的操作过程。ReflACTION 框架可用于描述和指导 CPS 的实施过程。我们希望所提出的框架能为实施科学增添知识,并最终实现预期的患者疗效。
{"title":"ReflACTION framework: A proposed model for implementation of clinical pharmacy services","authors":"Kérilin Stancine Santos Rocha ,&nbsp;Sabrina Cerqueira-Santos ,&nbsp;Genival Araújo dos Santos-Júnior ,&nbsp;Lincoln Marques Cavalcante-Santos ,&nbsp;Fernando de Castro Araújo-Neto ,&nbsp;Fernanda Oliveira Prado ,&nbsp;Giselle de Carvalho Brito ,&nbsp;Divaldo Pereira de Lyra-Jr.","doi":"10.1016/j.rcsop.2024.100534","DOIUrl":"10.1016/j.rcsop.2024.100534","url":null,"abstract":"<div><div>The implementation of clinical pharmacy services (CPS) has grown worldwide. However, few studies have used models and/or frameworks to facilitate the implementation process, especially in a low and middle-income countries. In addition, there are limitations in the ways that implementation frameworks are used. Therefore, this discussion aimed to propose and describe an approach using the ReflACTION framework. ReflACTION emerged from several years of systematic observation and experience of the Laboratory of Teaching and Research in Social Pharmacy (LEPFS) in implementing CPS in different settings of Brazilian health system. These experiences led the research group to systematize the implementation of CPS based on three theorical references: Paulo Freire's theoretical references, the Maguerez Arc and the Apoteca framework. The ReflACTION framework proposes five steps that starts and ends in the setting, which are: observation of reality; gathering key-points; theorization; solution hypothesis; and application to reality. All steps were carried out considering the determinants of the implementation process. For the present study, we highlight the importance of the implementation team, the involvement of stakeholders as well as their dialogue and awareness. Thus, we describe the operationalization process for each step. The ReflACTION framework can be used to describe and guide the implementation process of CPS. We expect the proposed framework may add knowledge to implementation science and, ultimately, achieve desired patient outcomes.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100534"},"PeriodicalIF":1.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parent perspectives on the design, implementation, and use of the parent E-cigarette and vaping educational resource (P-EVER) 家长对电子烟和吸烟教育资源(P-EVER)的设计、实施和使用的看法
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-10-20 DOI: 10.1016/j.rcsop.2024.100532
Olufunmilola Abraham , Zachary Paulsen , Evan Slonac , Jenny Li

Background

Adolescent use of e-cigarettes has been recognized as a significant public health concern as rates of adolescent vaping increase. As evidence of respiratory damage and other health concerns continue to emerge, educational resources for parents are critical in combating the vaping epidemic. A vaping educational tool can serve as a resource that parents of adolescents can reference to learn about e-cigarette use and how to address this topic with their families.

Objective

The purpose of this study was to examine parents' perspectives on the design and use of an educational infographic (Parent E-Cigarette and Vaping Educational Resource; P-EVER) to inform parents of adolescents and their families about e-cigarette use, risks, and quitting resources.

Methods

Parents who had an adolescent aged 12 to 18 years were recruited through community pharmacies in Wisconsin through recruitment fliers, emails, and word of mouth between February and June 2023. Participants reviewed the vaping educational handout in a semi-structured interview that was recorded and transcribed verbatim. Two members of the research team independently coded each transcript using NVivo software to conduct inductive thematic analysis. Bi-weekly meetings were held to refine codes, develop the master codebook, and identify prevalent themes (intercoder reliability - 0.83).

Results

Thirty-five parents were interviewed between February and June 2023. Four themes were identified: vaping awareness, P-EVER content and implementation, pharmacist's role, and barriers to pharmacist intervention on vaping. Participants believed the vaping educational handout was an effective resource for disseminating information to parents of adolescents. Responses highlighted the importance of providing educational resources to initiate conversations surrounding health risks to adolescents.

Conclusion

Pharmacists played a crucial role in successfully disseminating the P-EVER education tool to parents of adolescents. Future work is required to determine effective interventions for pharmacists and adolescents to discuss the topic of vaping awareness and safety.
背景随着青少年吸食电子烟比例的上升,青少年使用电子烟已被公认为一个重大的公共卫生问题。随着呼吸系统损伤和其他健康问题的证据不断涌现,为家长提供教育资源对于打击吸食电子烟的流行至关重要。本研究的目的是研究家长对教育信息图表(家长电子烟和吸食电子烟教育资源;P-EVER)的设计和使用的看法,以便向青少年家长及其家人介绍电子烟的使用、风险和戒烟资源。方法 在 2023 年 2 月至 6 月期间,通过威斯康星州的社区药店,以招募传单、电子邮件和口口相传的方式招募有 12 至 18 岁青少年的家长。参与者在半结构化访谈中阅读了吸食电子烟教育手册,访谈过程被逐字记录和转录。研究小组的两名成员使用 NVivo 软件对每份记录誊本进行独立编码,以进行归纳式主题分析。研究小组每两周举行一次会议,以完善编码、编制主编码本并确定普遍存在的主题(编码间可靠性为 0.83)。结果在 2023 年 2 月至 6 月期间,研究小组对 35 名家长进行了访谈。确定了四个主题:对吸食电子烟的认识、P-EVER 的内容和实施、药剂师的作用以及药剂师干预吸食电子烟的障碍。参与者认为,吸食电子烟教育手册是向青少年家长传播信息的有效资源。结论药剂师在向青少年家长成功传播 P-EVER 教育工具方面发挥了至关重要的作用。今后的工作需要确定有效的干预措施,以便药剂师和青少年讨论关于吸食电子烟的意识和安全话题。
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引用次数: 0
期刊
Exploratory research in clinical and social pharmacy
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