Exploratory research in clinical and social pharmacy最新文献

{"title":"Impact of pharmaceutical care interventions on antidepressants adherence and clinical outcomes in depressed patients: A systematic review","authors":"Nirmal Raj Marasine ,&nbsp;Sabina Sankhi ,&nbsp;Shishir Paudel ,&nbsp;Anisha Chalise ,&nbsp;Rajendra Lamichhane","doi":"10.1016/j.rcsop.2025.100644","DOIUrl":"10.1016/j.rcsop.2025.100644","url":null,"abstract":"<div><h3>Background</h3><div>Medication non-adherence, impaired health-related quality of life (HRQoL), increased depression severity, and patient dissatisfaction are common challenges among patients with depression. This systematic review aimed to evaluate the impact of pharmaceutical care interventions (PCIs) on antidepressant adherence, HRQoL, depression severity, and patient satisfaction.</div></div><div><h3>Methods</h3><div>This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted across PubMed, EMBASE, Web of Science, Scopus, PsycINFO, and CINAHL for randomized controlled trials (RCTs) published between 2000 and 2024. Studies evaluating pharmacist-led pharmaceutical care interventions aimed at improving antidepressant use and related outcomes were included. Data extraction and risk of bias assessment were performed using standardized forms and the Cochrane Collaboration's Risk of Bias tool.</div></div><div><h3>Results</h3><div>Fifteen RCTs met the inclusion criteria. Common intervention strategies included patient education, counseling, telephone follow-ups, and drug monitoring. Nine studies reported statistically significant improvements in antidepressant adherence. Of the three studies assessing HRQoL, one demonstrated significant improvement. Four of thirteen studies showed a significant reduction in depression severity, and three of five studies reported increased patient satisfaction in the intervention group compared to controls<strong>.</strong></div></div><div><h3>Conclusion</h3><div>Pharmaceutical care interventions, particularly patient education and counseling, contribute meaningfully in improving antidepressant adherence and related patient outcomes. However, findings across studies are inconsistent due to variability in intervention components, measurement tools, delivery methods, and outcome measures. Further research should focus on well-designed, large randomized trials with standardized, therory-based interventions.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100644"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health educational interventions for pharmacists and pharmacy staff: A scoping review","authors":"Hayley Man ,&nbsp;Ajesh George ,&nbsp;Arash Rudman ,&nbsp;Meng-Wong Taing ,&nbsp;Angela Masoe ,&nbsp;Leanne Smith ,&nbsp;Woosung Sohn ,&nbsp;Bradley Christian","doi":"10.1016/j.rcsop.2025.100658","DOIUrl":"10.1016/j.rcsop.2025.100658","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral diseases are a significant public health issue globally, however timely access to healthcare can assist in reducing this disease burden. Pharmacists and pharmacy staff are increasingly being recognised as a valuable health service resource, especially in rural-remote areas where access to dental services is limited. Access to oral health training is a challenge that has been identified to enable pharmacists and staff to integrate oral healthcare into their routine practice.</div></div><div><h3>Aim</h3><div>To identify and examine the characteristics of existing oral health education interventions for pharmacy staff including evaluation outcomes of the identified interventions.</div></div><div><h3>Method</h3><div>Medline, Embase and CINAHL databases were searched. Citation searching and a structured grey literature search was performed using search engine Google, OAIster, BASE, dental and pharmacy organization websites. The review method was informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (the PRISMA-ScR). Studies were eligible if they described an educational intervention focused on oral health for pharmacists or pharmacy staff, in any setting, and reported characteristics, content, delivery, or evaluation outcomes.</div></div><div><h3>Findings</h3><div>Ten oral health educational interventions for pharmacists and pharmacy staff were identified. The most common topics covered were general oral health promotion and management of common oral presentations in pharmacies. Most interventions had a single delivery format, such as a standalone online module or printed resource, rather than a suite of complementary materials combining multiple formats. Four were accredited as continuing professional development. Three identified interventions required membership to professional organisations. One resource had published literature on an evaluation process which reported that participants considered the content acceptable, relevant, and feasible to incorporate into pharmacy practice; however, it did not measure changes in knowledge, attitudes, confidence, or practice quantitatively.</div></div><div><h3>Conclusions</h3><div>There are very limited publicly accessible oral health educational interventions for pharmacy staff, and little evidence on their impact including KAP (Knowledge Attitudes and Practices), confidence, feasibility and acceptability. Addressing these gaps could support pharmacists to play a greater role in meeting oral health needs, particularly in underserved areas.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100658"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk perception, attitudes, and quality of life in a multicomponent benzodiazepine deprescription strategy","authors":"Ingrid Ferrer López ,&nbsp;Antonio Olry de Labry-Lima ,&nbsp;Alicia Gutiérrez-Valencia ,&nbsp;Encarnación García Bermúdez ,&nbsp;Francisco Atienza Martín ,&nbsp;Amalia García-Delgado Morente ,&nbsp;María Dolores Murillo Fernández ,&nbsp;Yolanda Sánchez Cañete ,&nbsp;Clara Bermúdez-Tamayo","doi":"10.1016/j.rcsop.2025.100666","DOIUrl":"10.1016/j.rcsop.2025.100666","url":null,"abstract":"<div><h3>Background</h3><div>Multicomponent strategies can reduce benzodiazepine (BZD) use. BenzoStopJuntos (Spanish for “Stop Benzos Together”), a multidisciplinary deprescribing programme of the Andalusian Health Service, supports patients to taper/stop BZD through education, behavioral support, and non-pharmacological alternatives. We evaluated whether early changes (6 months) in risk perception and attitudes—and secondarily, quality of life—were associated with long-term discontinuation of BZD.</div></div><div><h3>Methods</h3><div>In a quasi-experimental pre–post study in two primary care centres (Seville, Spain; <em>n</em> = 243), the intervention included patient education, tapering support, and alternatives for anxiety/insomnia delivered by a multidisciplinary team. Primary outcomes were (a) short-term (6-month) changes in risk perception and attitudes and (b) long-term BZD discontinuation over 5.5 years; the secondary outcome was quality of life (WONCA/COOP), monitored to detect potential harms. Multivariable logistic regression examined whether 6-month changes in beliefs/attitudes predicted subsequent discontinuation, adjusting for sociodemographic and clinical factors.</div></div><div><h3>Results</h3><div>BZD discontinuation increased from 31.3 % at 6 months to 40.7 % at 5.5 years. Participants who considered BZD safe long-term were more likely to continue use (OR = 2.0; 95 % CI: 1.6–2.6). Fears of worsened anxiety/sleep strongly predicted persistence (OR = 4.7; 95 % CI: 3.6–6.1). Prior intermittent vs continuous use favored discontinuation (OR = 4.9; 95 % CI: 3.7–6.5). Quality of life improved in emotional, social, and physical domains, with no deterioration observed during follow-up.</div></div><div><h3>Conclusions</h3><div>Tailored education and behavioral strategies changed risk perceptions and attitudes, which in turn facilitated sustained BZD discontinuation without adverse effects on quality of life. Addressing patient beliefs and encouraging intermittent use patterns may enhance deprescribing success.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> <span><span>NCT06209827</span><svg><path></path></svg></span></div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100666"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing access: Making naloxone available at highway rest areas","authors":"Tim Ingram ,&nbsp;Sofia Rubi ,&nbsp;Jennifer L. Brown ,&nbsp;Joel Sprunger ,&nbsp;Aimee Shadwick ,&nbsp;Clark Crago ,&nbsp;Michael S. Lyons ,&nbsp;T. John Winhusen","doi":"10.1016/j.rcsop.2025.100660","DOIUrl":"10.1016/j.rcsop.2025.100660","url":null,"abstract":"<div><h3>Background</h3><div>Naloxone is one of the most successful drugs in reversing the pharmacological effects of opioids and, in turn, preventing overdose. Increasing naloxone availability is an effective way to combat opioid-related overdose deaths. Recent changes in legislation across the United States have provided the jurisdiction to make naloxone more readily available. Naloxboxes are transparent, unsecured containers stocked with naloxone that are strategically placed in semi-private public spaces, such as restrooms.</div></div><div><h3>Objective</h3><div>To assess the effectiveness of installing naloxboxes at highway rest areas in Ohio as a strategy to increase public access to naloxone. This assessment draws on the pilot partnerships with the Ohio Department of Transportation, emergency medical services, and public health agencies, and explores implications for broader community implementation.</div></div><div><h3>Methods</h3><div>In collaboration with existing Ohio organizations, the HEALing Communities Study leveraged local and national funding to facilitate the expansion of naloxone use through the deployment of naloxone boxes at Ohio highway rest areas.</div></div><div><h3>Results</h3><div>Naloxboxes were found to be well accepted by the public and sustainable in highway rest areas. Their successful implementation and ongoing maintenance relied on multisectoral support, requiring collaboration across community organizations, public health agencies, and other stakeholders.</div></div><div><h3>Conclusion</h3><div>This innovative approach promoted the widespread distribution of naloxone while still preserving anonymity.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100660"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of non-prescription medication misuse in the geriatric population","authors":"Moaddey Alfarhan ,&nbsp;Jala Ashqar ,&nbsp;Jawaher Ajeebi ,&nbsp;Munira Ghazwani ,&nbsp;Nouf Alnahdi ,&nbsp;Yunus Yatimi ,&nbsp;Talal AlMohammed ,&nbsp;Khalid Khubrani ,&nbsp;Dania Saleh ,&nbsp;Haya Alsharif ,&nbsp;Saeed A. Alqahtani","doi":"10.1016/j.rcsop.2025.100663","DOIUrl":"10.1016/j.rcsop.2025.100663","url":null,"abstract":"<div><h3>Background</h3><div>Geriatric patients constitute the largest consumers of non-prescription medications. Understanding their patterns and consequences is essential.</div></div><div><h3>Aim</h3><div>This study investigated OTC medication misuse among adults aged 65 and older in Saudi Arabia. It aimed to determine the extent of misuse, identify common medication classes, and analyze associated health risks.</div></div><div><h3>Methods</h3><div>The study used a cross-sectional approach with 386 participants from various cities. Data were collected using a structured questionnaire delivered via two modes: an online survey and in-person interviews addressing demographics, medication use, drug interaction awareness, and educational needs. The sample ensured statistical accuracy, with a 5 % margin of error and a 95 % confidence level.</div></div><div><h3>Results</h3><div>The majority of participants (80.7 %) used over-the-counter medications, primarily painkillers (66.4 %). Notably, 28.5 % use five or more regular medications. Some exhibited misuse behaviors, including overdosing (14.2 %) and using OTC medications for non-recommended purposes. Additionally, 24.9 % reported drug-drug interactions. Awareness gaps were significant: 39.4 % were unaware of the dangers of misuse, 38.3 % did not know potential side effects, 43.5 % were unaware of interactions with prescribed medications, and 56.2 % did not know about contraindications. Correlation analysis revealed that participants aware of potential side effects (80.1 %) were less likely to misuse OTC drugs than those unaware (89.2 %) (<em>p</em> = 0.046), and those who understood contraindications (75.5 %) showed lower misuse rates than the unaware (86.6 %) (<em>p</em> = 0.049).</div></div><div><h3>Conclusion</h3><div>The study showed that most participants frequently used OTC medications, primarily analgesics, yet lacked knowledge about these drugs. It underscores the urgent need for interventions to prevent OTC misuse among the aging population, focusing on enhancing health literacy and safe drug practices. Recommended strategies include media campaigns and clinical programs to raise awareness about OTC misuse risks.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100663"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Australian pharmacists' experiences and perspectives in implementing a chronic kidney disease screening service in community pharmacies: A qualitative study","authors":"Ayana Korsa ,&nbsp;Ines Krass ,&nbsp;Connie Van ,&nbsp;Wubshet Tesfaye ,&nbsp;Natasa Gisev ,&nbsp;Anh Tran ,&nbsp;Rita McMorrow ,&nbsp;Breonny Robson ,&nbsp;Judith Fethney ,&nbsp;Vincent Versace ,&nbsp;Kamal Sud ,&nbsp;Lukas Kairaitis ,&nbsp;David Johnson ,&nbsp;Judy Mullan ,&nbsp;Sanjyot Vagholkar ,&nbsp;Ronald L. Castelino","doi":"10.1016/j.rcsop.2025.100643","DOIUrl":"10.1016/j.rcsop.2025.100643","url":null,"abstract":"<div><h3>Background</h3><div>The emerging role of pharmacists in chronic kidney disease (CKD) care prompted the pharmacy-led screening and quality use of medicines in CKD trial (QUM-CKD), a pharmacy-led screening initiative to detect previously undiagnosed CKD and improve medication safety.Objective: To explore pharmacists' experiences and perspectives on the implementation of the QUM-CKD trial in Australian community pharmacies.</div></div><div><h3>Methods</h3><div>A descriptive phenomenological qualitative approach was employed, involving in-depth, semi-structured telephone interviews with thirteen metropolitan and rural community pharmacists in the trial. Pharmacists were selected via purposive maximum variation sampling and were recruited mid-trial. Interviews were audio- recorded, transcribed verbatim, and thematically analysed using both deductive and inductive approaches in NVivo 14.</div></div><div><h3>Results</h3><div>Most participating pharmacists reported having positive experiences with the trial's implementation. Facilitators of implementation included pharmacists' knowledge and beliefs, the availability of resources, support and training. The alignment with roles, values, and systems, along with perceived benefits of the service, the point-of-care testing service, a whole-team approach, and patient acceptance coupled with positive feedback, also facilitated implementation. Barriers included insufficient pharmacist staffing, time constraints, heavy workload, trial software and documentation issues, patients' lack of time, interest or unfavourable perceptions of the service, and interprofessional communication challenges between pharmacists and general practitioners (GPs). Pharmacists also suggested several potential improvements and expressed concerns about the sustainability of the service.</div></div><div><h3>Conclusions</h3><div>Australian community pharmacists generally reported positive experiences in implementing the QUM-CKD trial. To ensure the service's success and sustainability, we recommend adequate pharmacy staffing, appropriate pharmacist remuneration, active stakeholder promotion and strong interprofessional collaboration. Pharmacists' suggestions for service improvement should also be considered.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100643"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criteria pharmacists use to refer patients to a post discharge pharmacist review clinic","authors":"Adrienne Kostellar ,&nbsp;Michael Barras ,&nbsp;Ian Coombes ,&nbsp;Andrew Hale ,&nbsp;Carla Scuderi ,&nbsp;Neil Cottrell ,&nbsp;Nazanin Falconer","doi":"10.1016/j.rcsop.2025.100647","DOIUrl":"10.1016/j.rcsop.2025.100647","url":null,"abstract":"<div><h3>Background</h3><div>The transition from hospital discharge to primary care is a critical period in a patient's healthcare journey. Health system errors occur, due to a breakdown in communication or lack of structured planning which can lead to medication related harm or hospital readmission. At a quaternary referral hospital in Australia, pharmacists refer Internal Medicine patients to a pharmacist-led clinic for post-discharge medication review. While clinical resources exist to guide identification of at-risk patients, it remains unclear if and to what extent, pharmacists incorporate these criteria into their referral.</div></div><div><h3>Aim</h3><div>To determine the criteria and reasons used by pharmacists to refer Internal Medicine patients to a post discharge pharmacist review clinic.</div></div><div><h3>Methods</h3><div>Semi-structured interviews were conducted with hospital pharmacists who had worked in Internal Medicine and previously referred patients to the post discharge review clinic. Interviews were conducted until data saturation was obtained. Interviews were audio recorded, transcribed and coded using NVivo®. Themes and subthemes were identified through inductive thematic analysis and finalised via discussion within the research team.</div></div><div><h3>Results</h3><div>Eleven pharmacists were interviewed. Five themes emerged describing referral criteria and reasons: (1) medication criteria including the use of high-risk medications and adjustments; (2) patient criteria including health status, frailty and social aspects of health including carer supports; (3) system pressures including patient flow and time constraints in care delivery; (4) post-discharge care including medication liaison and evaluation of tolerability and; (5) clinical judgement described as “worry” about the patient, highlighting the role of clinical reasoning.</div></div><div><h3>Conclusion</h3><div>Pharmacists used established criteria from clinical resources to identify high-risk patients for referral; however, they also relied on clinical judgement. Referrals aimed to prevent medication related harm and improve communication with patients and healthcare providers. Future research should evaluate the effectiveness of clinical judgement to ensure high-risk patients are identified for transition of care services.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100647"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and development of a mobile application for drug information and other health data for users and patients of pharmacies and outpatient pharmaceutical services","authors":"Raquel Agudelo ,&nbsp;Johan Granados ,&nbsp;Mauricio Ceballos ,&nbsp;Jaime Andrés Pereañez","doi":"10.1016/j.rcsop.2025.100661","DOIUrl":"10.1016/j.rcsop.2025.100661","url":null,"abstract":"<div><h3>Background</h3><div>The advancement of Information and Communication Technologies (ICT) has transformed multiple sectors, including healthcare, by enhancing access to information, optimizing service management, and reshaping interactions between healthcare professionals and users.</div></div><div><h3>Objective</h3><div>(1) To enhance the accessibility and quality of PC services, (2) to advance digital health implementation in Colombia by integrating pharmaceutical practice with innovative technological solutions that promote patient empowerment and patient- centered care models, (3) to demonstrate a comprehensive workflow for developing e- health applications using a User-Centered Design (UCD) approach.</div></div><div><h3>Methods</h3><div>The study employed a User-Centered Design (UCD) approach, structured in four phases: (1) identification of user needs through an exploratory review and a descriptive study; (2) gathering and prioritization of functional requirements using the MoSCoW method; (3) design and development of a prototype based on six thematic databases; and (4) usability testing through task-based user evaluations and satisfaction rating scales.</div></div><div><h3>Results</h3><div>A total of 72 functional requirements were identified and categorized into two main groups: those related to information provision and those linked to specific application features. Twenty functionalities were prioritized as essential, including drug information searches, healthy lifestyle guidance, medication intake reminders, and pharmacy geolocation. The final prototype comprised eight functional modules.Usability testing showed that 100 % of users completed most tasks, with task times under one minute and high satisfaction scores across all evaluated components.</div></div><div><h3>Conclusions</h3><div>The application demonstrated high levels of acceptance and usability, establishing itself as a potentially effective tool to improve access to pharmaceutical care services, empower patients, and promote safe medication use in outpatient settings. Additionally, the methodology presented in this study may serve as a reference for the development of future digital health tools.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100661"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of comprehensive pharmaceutical care on medication safety in gynecologic oncology chemotherapy patients","authors":"Zhiqi Zhang ,&nbsp;Zhuo Zhang ,&nbsp;Qianxin Liu ,&nbsp;Yan Zhang ,&nbsp;Peng Jia ,&nbsp;Lan Mi ,&nbsp;Rui Lian ,&nbsp;Fei Chen ,&nbsp;Xiaocong Pang ,&nbsp;Ying Zhou","doi":"10.1016/j.rcsop.2025.100681","DOIUrl":"10.1016/j.rcsop.2025.100681","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of our hospital's full-course pharmacy service on the safety and rationality of medication in patients with gynecologic malignancies undergoing chemotherapy.</div></div><div><h3>Methods</h3><div>A retrospective cohort analysis was conducted on patients who underwent chemotherapy in the Gynecologic Oncology Ward at Peking University First Hospital between September 2022 and September 2024. Patients were divided into a control group, who received routine pharmaceutical care based on clinical medication prescription review, and the intervention group, who received comprehensive pharmaceutical care throughout their treatment. This included prescription review, medication education, drug consultation, and adverse reaction management. The incidence of severe adverse reactions, the appropriateness of leukopoietic treatment and monitoring, and the rate of unplanned hospital admissions were compared between the two groups.</div></div><div><h3>Results</h3><div>The intervention group demonstrated a significantly lower incidence of severe nausea (6.1 % vs 11.4 %, <em>P</em> = 0.034), anorexia (3.3 % vs 9.3 %, <em>P</em> = 0.003), and leukopenia (9.4 % vs 15.7 %, P = 0.034) compared to the control group. Additionally, the appropriateness of leukopoietic treatment (93.5 % vs 85.0 %, <em>P</em> = 0.001) and monitoring (89.2 % vs 65.0 %, <em>P</em> &lt; 0.001), as well as the rate of unexpected hospital admissions (2.2 % vs 6.4 %, <em>P</em> = 0.013), have shown significant improvement in the intervention group.</div></div><div><h3>Conclusion</h3><div>Comprehensive pharmaceutical care has a positive impact on medication safety for gynecologic oncology patients, significantly reducing the incidence of severe adverse reactions and the rate of unplanned hospital admissions.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100681"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overemployment and underemployment of part-time pharmacists: Prevalence and connection to work-life characteristics","authors":"David A. Mott ,&nbsp;William R. Doucette ,&nbsp;Eilan Alhersh ,&nbsp;Vibhuti Arya ,&nbsp;Brianne K. Bakken ,&nbsp;Caroline Gaither ,&nbsp;David H. Kreling ,&nbsp;Jon C. Schommer ,&nbsp;Matthew Witry","doi":"10.1016/j.rcsop.2025.100673","DOIUrl":"10.1016/j.rcsop.2025.100673","url":null,"abstract":"<div><h3>Background</h3><div>Overemployment and underemployment are associated with fluctuations in labor supply and can negatively impact psychosocial aspects of work and worker health.</div></div><div><h3>Objectives</h3><div>The objectives of this study were to 1) determine the prevalence and characteristics of underemployment, overemployment and matched employment among part-time pharmacists; 2) examine differences in actual and ideal hours worked for overemployed and underemployed part-time pharmacists; and 3) test associations between overemployment, underemployment and matched employment and part-time pharmacists' perceptions of job quality and work-life characteristics.</div></div><div><h3>Methods</h3><div>Data for 636 pharmacists self-reporting working part-time (≤ 30 h/week) were extracted from the 2019 National Pharmacists Workforce Study. The difference in self-reported actual and ideal hours worked weekly was calculated and used to classify part-time pharmacists as overemployed, underemployed or matched employed. Differences between the variables were tested with multivariate ordinary least squares regression models.</div></div><div><h3>Results</h3><div>Being matched employed was most common (41.3 %) followed by underemployed (34.9 %) and being overemployed (23.8 %). Of underemployed respondents, over half (54.1 %) reported wanting to work full-time, which likely is reflective of the relatively loose national pharmacist labor market in 2019. Overemployed and underemployed respondents reported significantly lower levels of several of the work-life characteristics relative to those with matched employment.</div></div><div><h3>Conclusion</h3><div>The higher rate of underemployment among pharmacists working part-time is consistent with the surplus of US pharmacists in 2019. The results show that for pharmacists working part-time, a lack of control over how much they work is negatively associated with job quality and work-life characteristics relative to pharmacists with work schedule control.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100673"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}