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Measuring the impact of automated dispensing cabinets implementation on data and inventory management of human normal immunoglobulin in an acute teaching hospital: A pre- and post- intervention study 衡量自动配药柜的实施对一家急诊教学医院人正常免疫球蛋白数据和库存管理的影响:干预前后研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-24 DOI: 10.1016/j.rcsop.2024.100516
Alice Pinfield, Kit Lai, Shelley Jones

Background

Human Normal Immunoglobulin (HNIg) is a complex plasma-derived blood product used to treat a variety of medical conditions. Global supply problems have increased focus on HNIg stewardship, including mandatory recording of HNIg usage on the National Immunoglobulin Database (NIgD). Local departmental audits identified significant inconsistencies in data uploaded to NIgD. Inventory management issues caused a number of stock losses in the last financial year. A paper-based HNIg batch number recording system was replaced with the use of Automated Dispensing Cabinets (ADCs), which generated an electronic batch number report, with matching fields required for electronic upload to NIgD.

Aim

To measure the impact of ADC implementation on the accuracy of data uploaded to NIgD, HNIg stock control and staff time associated with processes of HNIg data and inventory management.

Method

Three months of pre- and post-implementation HNIg dispensing data was compared to the data uploaded to the NIgD for discrepancies. Inventory reports were used to identify unexplained stock adjustments. Time and motion methods were used to quantify staff time associated with HNIg activities.

Results

Pre-implementation: 20.7 % (3762.5 g/18,217 g) of HNIg by volume (23.7 % of dispensing episodes; 66/279) were inaccurately uploaded or absent on the NIgD and three stock adjustments were made (loss of >£15 k). Post-implementation: 12 % (2325 g/19,347 g) of HNIg by volume (10.8 % of dispensing episodes; 31/286) were inaccurately uploaded or absent on the NIgD and zero stock adjustments were observed; Mean time for dispensing per HNIg prescription reduced from 17 min to 8 min; Time spent uploading data to NIgD per month reduced from 5 h to 1.75 h.

Discussion/Conclusion

The use of ADCs improved accuracy of NIgD data upload. Following implementation direct observations have cited unregistered or finished patient episodes, dispensing procedural compliance, and user familiarity with the system as common reasons for incomplete data uploads to NIgD. The new ADC process had consequences of forcing dispensing procedure compliance to improve uploads, whilst reducing dispensing times. It led to improved stock control and removed upload burden from dispensers. ADC stock discrepancy alerts allowed staff to proactively resolve discrepancies in real time. Time taken for additional processes to support management of stocks in ADCs, including monthly stock cycle counts, were important considerations for implementation. The key advantage of using ADC batch number reports is the ability to upload as a single monthly batch without having to manually access individual patient records on the NIgD. It facilitates early identification of failed upload attempts and supports resolution of stock discrepancies.
背景人体正常免疫球蛋白(HNIg)是一种复杂的血浆衍生血液制品,用于治疗多种疾病。全球供应问题使人们更加关注 HNIg 的管理,包括在国家免疫球蛋白数据库 (NIgD) 中强制记录 HNIg 的使用情况。地方部门审计发现,上传到 NIgD 的数据严重不一致。库存管理问题在上一财政年度造成了一些库存损失。使用自动配药柜(ADC)取代了纸质 HNIg 批号记录系统,自动配药柜可生成电子批号报告,并提供电子上传到 NIgD 所需的匹配字段。方法将实施前和实施后三个月的 HNIg 配药数据与上传到 NIgD 的数据进行比较,找出差异。库存报告用于识别无法解释的库存调整。结果实施前:20.7%(3762.5 克/18217 克)的 HNIg(占配药次数的 23.7%;66/279)在 NIgD 上上传不准确或缺失,并进行了三次库存调整(损失 1.5 万英镑)。实施后:12%(2325 克/19,347 克)的 HNIg(按用量计算)(配药次数的 10.8%;31/286)在 NIgD 上上载不准确或缺失,库存调整次数为零;每张 HNIg 处方的平均配药时间从 17 分钟减少到 8 分钟;每月上载数据到 NIgD 的时间从 5 小时减少到 1.75 小时。在实施后的直接观察中发现,未登记或已完成的患者病程、配药程序合规性以及用户对系统的熟悉程度是导致向 NIgD 上传数据不完整的常见原因。新的 ADC 流程的结果是,强制配药程序合规以改进上传,同时减少配药时间。它改善了库存控制,减轻了配药员的上传负担。ADC 库存差异警报使员工能够实时主动地解决差异问题。支持 ADC 库存管理的其他流程(包括每月库存周期清点)所需的时间是实施时的重要考虑因素。使用 ADC 批次号报告的主要优势在于,它能够作为单个月度批次上传,而无需手动访问 NIgD 上的单个患者记录。这有助于及早识别上传失败的尝试,并支持解决库存差异问题。
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引用次数: 0
Involving community pharmacies in management of late effects of cancer treatment: Opinions from cancer survivors. 让社区药房参与癌症晚期治疗效果管理:癌症幸存者的意见。
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-21 DOI: 10.1016/j.rcsop.2024.100514
Nadia Lund Olsen , Ramune Jacobsen , Linda Aagaard Thomsen , Lotte Stig Nørgaard

Background

More than 50 % of cancer survivors experience late effects of cancer (LEC). Current models of follow-up care often prove inadequate, resulting in unresolved LEC. Given the pivotal role of community pharmacists as the most accessible healthcare professionals and the demonstrated benefits of evidence-based pharmacy services on patient centered care, exploring the potential contribution of community pharmacies in managing LEC is relevant.

Objective

This study aimed to investigate cancer survivors' needs, preferences, and attitudes regarding pharmacy involvement in managing LEC.

Method

The developed questionnaire based on validated instruments underwent a pilot test among cancer survivors at four Danish community pharmacies. In August 2021, the questionnaire was distributed to all 611 cancer survivors of the Danish Cancer Society's cancer patient panel. The resulting quantitative data were subjected to descriptive statistical analysis, while qualitative data underwent a thematic content analysis.

Results

Among the 611 panel members, 354 responded to the questionnaire (response rate 58 %). Fatigue was the most frequent LEC experienced by 88 % of respondents. Three out of four (75 %) of respondents expressed dissatisfaction with the level of counseling they had received regarding LEC, and 23 % disclosed not having discussed LEC with a healthcare professional despite feeling the need to do so. Nearly all respondents visited pharmacies annually and used available products to alleviate LEC. Approximately half of respondents expressed a need for counseling on the appropriate use of these products. While nearly half of respondents were receptive to pharmacy-based counseling, concerns regarding discretion and staff knowledge were prevalent.

Conclusion

Cancer survivors experience an insufficiency in counseling on LEC and demonstrate an openness towards involving community pharmacies in addressing this gap. However, further investigation is warranted to delineate survivors' specific needs and expectations regarding community pharmacy involvement in LEC management. Additionally, suggestions from survivors underscore the importance of enhancing pharmacy staff knowledge and establishing discreet counseling areas.
背景50%以上的癌症幸存者会出现癌症晚期反应(LEC)。目前的后续护理模式往往被证明是不够的,导致 LEC 无法解决。鉴于社区药剂师作为最容易获得的医疗保健专业人员所发挥的关键作用,以及以证据为基础的药学服务对以患者为中心的护理所带来的益处,探索社区药房在管理 LEC 方面的潜在贡献具有重要意义。这项研究旨在调查癌症幸存者对药房参与管理 LEC 的需求、偏好和态度。2021 年 8 月,该问卷被分发给丹麦癌症协会癌症患者小组的所有 611 名癌症幸存者。对所得定量数据进行了描述性统计分析,并对定性数据进行了主题内容分析。88%的受访者认为疲劳是最常见的 LEC。每四位受访者中就有三位(75%)对他们所接受的有关 LEC 的咨询水平表示不满,23% 的受访者透露,尽管觉得有必要与医护人员讨论 LEC,但他们并没有这样做。几乎所有的受访者每年都会去药店买药,并使用现有的产品来缓解 LEC。大约一半的受访者表示需要就如何正确使用这些产品进行咨询。尽管近一半的受访者愿意接受药房提供的咨询服务,但他们普遍对药房的谨慎性和工作人员的知识表示担忧。然而,还需要进一步调查,以确定幸存者对社区药房参与 LEC 管理的具体需求和期望。此外,幸存者提出的建议强调了加强药房员工知识和建立独立咨询区的重要性。
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引用次数: 0
Prescribers' perspectives: The impact of the controlled substance scheduling system on providing optimal patient care 处方者的观点:受管制物质列表系统对提供最佳患者护理的影响
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-21 DOI: 10.1016/j.rcsop.2024.100511
Michael R. Barnes , Yijia Luo , Jonathon M. Parker , Brian M. Shepler

Background

In the United States, the scheduling system for controlled substances was established by the Controlled Substance Act of 1970. In 2009, Parker et al. published the study “Physicians' knowledge and attitudes toward scheduling.” Since 2009, the opioid epidemic has gathered national attention from social and scientific perspectives as the number of drug overdose deaths in the United States has nearly tripled.

Objective

To follow up on a 2009 survey by Parker, et al. to determine prescribers' knowledge and attitudes regarding the controlled substance scheduling system and assess the impact of the controlled substance scheduling system on providing optimal patient care.

Methods

The cross-sectional survey was designed to assess prescribers' attitudes and mailed to 400 randomly selected physicians and 400 randomly selected nurse practitioners.

Results

Prescribers across all groups provided consistent responses suggesting an overall lack of understanding of controlled substance regulations, a negative attitude towards the controlled substance scheduling system, and a detrimental effect on providing optimal patient care. Responses from nurse practitioners differed significantly from physicians in 75 % (3 of the 4) questions regarding regulations, suggesting nurse practitioners possess a greater understanding of pharmaceutical regulations. Specialists' responses demonstrated an enhanced level of dissatisfaction regarding the controlled substance scheduling system compared to primary care providers in 75 % (3 of the 4) questions. Questions regarding the impact of the scheduling system on prescribing patterns differed significantly across multiple demographic groups, notably between physicians and nurse practitioners, differences in practice setting, and primary state of practice for 75 % (3 of the 4) questions.

Conclusions

The results of this survey confirm the findings of Parker, et al., and further display the need for investigation into how to improve the controlled substance scheduling system in the United States.
背景美国 1970 年的《受控物质法案》建立了受控物质的列表系统。2009 年,Parker 等人发表了题为 "医生对列表的认识和态度 "的研究报告。自 2009 年以来,阿片类药物的流行引起了社会和科学界的广泛关注,因为美国药物过量致死的人数几乎增加了两倍。目的对 Parker 等人 2009 年的调查进行跟踪,以确定处方医生对管制药物排期制度的了解和态度,并评估管制药物排期制度对提供最佳患者护理的影响。方法该横断面调查旨在评估处方者的态度,并邮寄给了随机抽取的 400 名医生和 400 名执业护士。结果所有组别的处方者都给出了一致的回答,表明他们对管制物质法规总体缺乏了解,对管制物质调度系统持消极态度,并认为该系统不利于提供最佳的患者护理。执业护士在 75% 的问题(4 个问题中的 3 个)上的回答与医生的回答有明显不同,这表明执业护士对药品法规有更深入的了解。在 75%(4 个问题中的 3 个)的问题中,专科医生的回答比初级保健提供者对管制药物排班系统的不满程度更高。关于调度系统对处方模式的影响的问题在多个人口统计群体中存在显著差异,尤其是在医生和执业护士之间、执业环境差异以及主要执业州的 75% (4 个问题中的 3 个)问题上。
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引用次数: 0
Assessing the psychometric properties of Connor-Davidson Resilience Scale 25 (CD-RISC 25) in pharmacy students and academics in the Eastern Mediterranean Region 评估康纳-戴维森复原力量表 25 (CD-RISC 25) 在东地中海地区药学专业学生和学者中的心理测量特性
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-21 DOI: 10.1016/j.rcsop.2024.100515
Mona Almanasef , Dalia Bajis , Asmaa Al-Haqan , Saja Alnahar , Ian Bates

Background

Resilience is a complex concept that is defined and influenced by the context of individuals, organisations, societies and cultures. The Connor-Davidson Resilience Scale (CD-RISC) is a widely used validated tool to evaluate psychological resilience. CD-RISC is a self-administered scale of twenty-five items, each rated by a 5-point Likert scale. The scale evaluates overall personal resilience through assessing five main resilience-related constructs; personal competence, trust in one's instincts, positive acceptance of change, control and spiritual influences. As per the scale's developers, higher scores reflecting greater level of resilience. This particular tool has not previously been tested with a pharmacy student or academic population sample.

Objective

This study aims to assess the factor structure, validity, and reliability of the CD-RISC-25 in a sample of pharmacy students and academics from faculties drawn across the Eastern Mediterranean Region (EMR).

Methods

A cross-sectional study was carried out between October 2020 and January 2021 sampling pharmacy students and academics across the EMR who were invited to complete the self-administered CD-RISC 25 questionnaire. Confirmatory factor analysis using principal components analysis with oblique rotation was conducted on sample responses (n = 616). The internal consistency and reliability for each identified factor and from the CD-RISC scale was evaluated by using Cronbach's alpha coefficient.

Results

Five factors were isolated accounting for 51.5 % total cumulative model variance. Identification of factors showed high convergence with previous work on the CD-RISC resilience tool. The current study in our sample found a five–factor structure which differed from the original scale reliabilities. This study did identify a five-factor solution with differing item factor loadings. The reliability analysis on the CD-RISC-25 items in our study sample revealed an overall Cronbach Alpha value of 0.89; however, three items showed corrected Item-total correlations of <0.3. Our analysis, in this respondent sample, suggested a re-adjustment of the scale inclusions to improve overall scale stability and performance.

Conclusions

The current research findings propose a modified five-factor structure to resilience, with a 22-item unidimensional model of CD-RISC scale.
背景抗逆力是一个复杂的概念,它受到个人、组织、社会和文化背景的界定和影响。康纳-戴维森复原力量表(CD-RISC)是一种广泛使用的评估心理复原力的有效工具。CD-RISC 是一个由二十五个项目组成的自编量表,每个项目均采用李克特五点量表评分。该量表通过评估与抗逆力相关的五个主要构念,即个人能力、对自身本能的信任、对变化的积极接受、控制力和精神影响,来评价个人的整体抗逆力。根据量表开发者的说法,分数越高,抗逆力越强。本研究旨在对 CD-RISC-25 的因子结构、有效性和可靠性进行评估,样本来自东地中海地区(EMR)的药学系学生和学者。采用主成分分析和斜向旋转对样本回答(n = 616)进行了确认性因子分析。使用 Cronbach's alpha 系数评估了每个已识别因子和 CD-RISC 量表的内部一致性和可靠性。这些因子的确定与之前关于 CD-RISC 抗挫折能力工具的研究结果高度一致。本研究在我们的样本中发现了一个五因素结构,它与原始量表的信度有所不同。本研究确实发现了一个五因素解决方案,其项目因素负荷各不相同。在我们的研究样本中,CD-RISC-25 项目的信度分析表明,总体 Cronbach Alpha 值为 0.89;但是,有三个项目的修正项目-总相关系数为 <0.3。我们对这一受访样本的分析表明,应重新调整量表的内容,以提高量表的整体稳定性和表现。
{"title":"Assessing the psychometric properties of Connor-Davidson Resilience Scale 25 (CD-RISC 25) in pharmacy students and academics in the Eastern Mediterranean Region","authors":"Mona Almanasef ,&nbsp;Dalia Bajis ,&nbsp;Asmaa Al-Haqan ,&nbsp;Saja Alnahar ,&nbsp;Ian Bates","doi":"10.1016/j.rcsop.2024.100515","DOIUrl":"10.1016/j.rcsop.2024.100515","url":null,"abstract":"<div><h3>Background</h3><div>Resilience is a complex concept that is defined and influenced by the context of individuals, organisations, societies and cultures. The Connor-Davidson Resilience Scale (CD-RISC) is a widely used validated tool to evaluate psychological resilience. CD-RISC is a self-administered scale of twenty-five items, each rated by a 5-point Likert scale. The scale evaluates overall personal resilience through assessing five main resilience-related constructs; personal competence, trust in one's instincts, positive acceptance of change, control and spiritual influences. As per the scale's developers, higher scores reflecting greater level of resilience. This particular tool has not previously been tested with a pharmacy student or academic population sample.</div></div><div><h3>Objective</h3><div>This study aims to assess the factor structure, validity, and reliability of the CD-RISC-25 in a sample of pharmacy students and academics from faculties drawn across the Eastern Mediterranean Region (EMR).</div></div><div><h3>Methods</h3><div>A cross-sectional study was carried out between October 2020 and January 2021 sampling pharmacy students and academics across the EMR who were invited to complete the self-administered CD-RISC 25 questionnaire. Confirmatory factor analysis using principal components analysis with oblique rotation was conducted on sample responses (<em>n</em> = 616). The internal consistency and reliability for each identified factor and from the CD-RISC scale was evaluated by using Cronbach's alpha coefficient.</div></div><div><h3>Results</h3><div>Five factors were isolated accounting for 51.5 % total cumulative model variance. Identification of factors showed high convergence with previous work on the CD-RISC resilience tool. The current study in our sample found a five–factor structure which differed from the original scale reliabilities. This study did identify a five-factor solution with differing item factor loadings. The reliability analysis on the CD-RISC-25 items in our study sample revealed an overall Cronbach Alpha value of 0.89; however, three items showed corrected Item-total correlations of &lt;0.3. Our analysis, in this respondent sample, suggested a re-adjustment of the scale inclusions to improve overall scale stability and performance.</div></div><div><h3>Conclusions</h3><div>The current research findings propose a modified five-factor structure to resilience, with a 22-item unidimensional model of CD-RISC scale.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100515"},"PeriodicalIF":1.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral factors associated with medication adherence among hypertensive patients using the theoretical domains framework 利用理论领域框架分析与高血压患者坚持服药相关的行为因素
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-17 DOI: 10.1016/j.rcsop.2024.100510
Van De Tran , Thi My Loan Vo , Quang Loc Duyen Vo , Minh Trung Nguyen , Minh Cuong Nguyen , Rebecca Susan Dewey , Thi Hai Yen Nguyen

Background

Theoretical exploration of the behavioral factors associated with adherence to medication in hypertensive patients has been limited in previous studies.

Objectives

This study aims to understand the associations between demographic and health characteristics and behavioral factors for medication taking, and how these predict medication adherence.

Methods

A cross-sectional survey was conducted in hypertensive outpatients, with a sample size of 399 participants. Behavioral factors predicting medication taking, designed to align with the theoretical domains framework, and the medication adherence scale were used. Behavioral factors were determined using principal component analysis, and their associations with demographic and health characteristics and medication adherence were analyzed using non-parametric statistics.

Results

Four behavioral factors were identified: (F1) negative emotions and beliefs about capabilities, (F2) beliefs about consequences, (F3) knowledge and skills, and (F4) social support. F1 showed a strongest inverse association with medication adherence (ρ = −0.25; p < 0.01). Significantly higher F1 scores were recorded in hypertensive patients with secondary school or lower education (p < 0.001), income less than 4 million VND (p = 0.03), who were currently smoking (p = 0.018), self-reporting chest pain or discomfort (p < 0.001), and of older age (p < 0.01).

Conclusions

Certain demographic and health characteristics were significantly associated with emotions and beliefs about capabilities to take medication, which, in turn, was significantly associated with medication adherence. Future research should design interventions that focus on reassuring patients of the need and of their ability to overcome their worries and sadness and reduce their difficulties in using medications.
背景以往的研究对与高血压患者坚持服药相关的行为因素进行的理论探讨十分有限。采用了与理论领域框架相一致的预测服药行为因素和服药依从性量表。采用主成分分析法确定行为因素,并采用非参数统计法分析行为因素与人口统计学特征、健康特征和服药依从性之间的关系:(结果确定了四个行为因素:(F1)消极情绪和能力信念;(F2)后果信念;(F3)知识和技能;(F4)社会支持。F1 与服药依从性呈最强的反向关系 (ρ = -0.25; p < 0.01)。结论某些人口和健康特征与服药能力的情绪和信念显著相关,而服药能力又与服药依从性显著相关。未来的研究应设计干预措施,重点是让患者相信他们有必要和有能力克服忧虑和悲伤,减少用药困难。
{"title":"Behavioral factors associated with medication adherence among hypertensive patients using the theoretical domains framework","authors":"Van De Tran ,&nbsp;Thi My Loan Vo ,&nbsp;Quang Loc Duyen Vo ,&nbsp;Minh Trung Nguyen ,&nbsp;Minh Cuong Nguyen ,&nbsp;Rebecca Susan Dewey ,&nbsp;Thi Hai Yen Nguyen","doi":"10.1016/j.rcsop.2024.100510","DOIUrl":"10.1016/j.rcsop.2024.100510","url":null,"abstract":"<div><h3>Background</h3><div>Theoretical exploration of the behavioral factors associated with adherence to medication in hypertensive patients has been limited in previous studies.</div></div><div><h3>Objectives</h3><div>This study aims to understand the associations between demographic and health characteristics and behavioral factors for medication taking, and how these predict medication adherence.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted in hypertensive outpatients, with a sample size of 399 participants. Behavioral factors predicting medication taking, designed to align with the theoretical domains framework, and the medication adherence scale were used. Behavioral factors were determined using principal component analysis, and their associations with demographic and health characteristics and medication adherence were analyzed using non-parametric statistics.</div></div><div><h3>Results</h3><div>Four behavioral factors were identified: (F1) negative emotions and beliefs about capabilities, (F2) beliefs about consequences, (F3) knowledge and skills, and (F4) social support. F1 showed a strongest inverse association with medication adherence (ρ = −0.25; <em>p</em> &lt; 0.01). Significantly higher F1 scores were recorded in hypertensive patients with secondary school or lower education (<em>p</em> &lt; 0.001), income less than 4 million VND (<em>p</em> = 0.03), who were currently smoking (<em>p</em> = 0.018), self-reporting chest pain or discomfort (<em>p</em> &lt; 0.001), and of older age (<em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Certain demographic and health characteristics were significantly associated with emotions and beliefs about capabilities to take medication, which, in turn, was significantly associated with medication adherence. Future research should design interventions that focus on reassuring patients of the need and of their ability to overcome their worries and sadness and reduce their difficulties in using medications.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100510"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Montelukast deprescribing in outpatient specialty clinics: A single center cross-sectional study 门诊专科诊所的孟鲁司特去势:单中心横断面研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-17 DOI: 10.1016/j.rcsop.2024.100509
David C. Foote , Jamie L. Miller , Grant H. Skrepnek , Stephen Neely , Kiya Bennett , Paul M. Boylan

Objective

To identify and evaluate montelukast deprescribing in outpatient specialty clinics.

Methods

This was a single-center, retrospective, cross-sectional study conducted at an academic health system in the southern US including 21 specialty clinics. Subjects included adults ≥18 years with an active prescription for montelukast who attended at least one appointment in pulmonology, otolaryngology, or neurology outpatient specialty clinics between January 1, 2021 to December 31, 2022. Patients <18 years and those with diagnoses of uncontrolled asthma or allergic rhinitis were excluded. Outcomes assessed included the frequency and period prevalence of montelukast deprescribing, defined by a documented montelukast discontinuation within the medical record, and evaluation of reasoning for discontinuation mentioned in visit notes.

Results

There were 1152 patients who met inclusion criteria. Of these, 43 (3.7 %) experienced a montelukast deprescribing event: 18 (41.9 %) in neurology, 13 (30.2 %) in otolaryngology, and 12 (27.9 %) in pulmonology. Documented reasons for deprescribing were only available for 11 patients (25.6 %); reasons for deprescribing included patient-provider shared decision-making regarding the Black Box Warning [n = 5 (11.6 %)], inadequate treatment response [n = 3 (7.0 %)], suicidal thought development [n = 1 (2.3 %)], adverse drug event [n = 1 (2.3 %)], and pregnancy planning [n = 1 (2.3 %)].

Conclusion

Montelukast deprescribing rates were less than 5 % in outpatient specialty clinics. Factors associated with montelukast deprescribing beget further investigation.

方法 这是一项单中心、回顾性、横断面研究,在美国南部的一个学术医疗系统进行,包括 21 个专科门诊。研究对象包括 2021 年 1 月 1 日至 2022 年 12 月 31 日期间在肺科、耳鼻喉科或神经内科专科门诊至少就诊过一次、持有孟鲁司特有效处方、年龄≥18 岁的成人。18岁及诊断为哮喘或过敏性鼻炎未得到控制的患者除外。评估的结果包括停用孟鲁司特的频率和时期流行率(定义为病历中记录的孟鲁司特停药情况),以及对就诊记录中提到的停药原因进行评估。其中,43 例(3.7%)发生了孟鲁司特停药事件:神经内科 18 例(41.9%),耳鼻喉科 13 例(30.2%),肺科 12 例(27.9%)。仅有 11 名患者(25.6%)提供了有记录的停药原因;停药原因包括:患者与医护人员共同决定黑框警告 [n = 5 (11.6%)]、治疗反应不充分 [n = 3 (7.0%)]、有自杀倾向 [n = 3 (7.0%)]。结论孟鲁司特在专科门诊的停药率低于 5%。与停用孟鲁司特相关的因素有待进一步调查。
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引用次数: 0
Empowering precision medicine: Insights from a national survey on pharmacogenomics knowledge, attitudes, and perceptions among community pharmacists in the UAE 为精准医疗赋能:阿联酋社区药剂师对药物基因组学知识、态度和看法的全国性调查透视
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-12 DOI: 10.1016/j.rcsop.2024.100508
Ammar Abdulrahman Jairoun , Sabaa Saleh Al-Hemyari , Moyad Shahwan , Mena Al-Ani , Mustafa Aal Yaseen , Mahmood H. Al-Aawad , Ghala Rashid Alnuaimi , B. Mahalakshmi

Background

Community pharmacists are essential to pharmacogenomics implementation because they can help trainers, clinical advisors, and other medical professionals understand the importance of pharmacogenomics and encourage them to use it in their practice. This study is to evaluate the community pharmacists' understanding, attitudes, and perceptions of pharmacogenomics in the United Arab Emirates (UAE).

Methods

Professionals employed at community pharmacies in Abu Dhabi, Dubai, and the Northern Emirates participated in a cross-sectional study design. From July 2023 to February 2024, five pharmacy students in their last year conducted the survey. The study team employed a structured questionnaire to collect data in addition to conducting in-person interviews. The study questionnaire comprised three distinct sections namely, demographic information, knowledge of pharmacogenomics concepts, and perceptions regarding pharmacogenomics.

Results

A total of 586 pharmacists enrolled in the study. The average knowledge score regarding pharmacogenomics was 75.1 % with a 95 % confidence interval (CI) of [72.4 %, 77.7 %]. The average attitude score toward pharmacogenomics was 67.5 % with a 95 % CI of [66.3 %, 68.7 %]. Better pharmacogenomics knowledge among several groups: independent pharmacies (OR 1.7; 95 % CI 1.2–2.4), Pharmacists in Charge (OR 1.4; 95 % CI 1.3–2.02), pharmacists with 11–15 years of experience (OR 2.1; 95 % CI 1.4–4.2), graduates from international universities (OR 4.6; 95 % CI 1.6–12.9), and those who received training on pharmacogenomics (OR 11.9; 95 % CI 3.3–14.5). Similarly, better attitude scores were observed among independent pharmacies (OR 1.5; 95 % CI 1.1–2.1), Pharmacists in Charge (OR 1.5; 95 % CI 1.07–2.1), pharmacists with 16–20 years of experience (OR 2.1; 95 % CI 1.16–3.7), graduates regional universities (OR 1.47; 95 % CI 1.05–2.1), and those who received training on pharmacogenomics (OR 4.8; 95 % CI 3.2–7.3).

Conclusion

The positive attitudes toward pharmacogenomics that we found in our research indicate that community pharmacists in the United Arab Emirates are beginning to realize the potential advantages of pharmacogenomics in terms of improving patient care. Policies ensuring the privacy and confidentiality of genetic information are also necessary in considering concerns about the availability of genetic test results to insurance companies and potential employers.
背景社区药剂师对药物基因组学的实施至关重要,因为他们可以帮助培训师、临床顾问和其他医疗专业人员了解药物基因组学的重要性,并鼓励他们在实践中使用药物基因组学。本研究旨在评估阿拉伯联合酋长国(UAE)社区药剂师对药物基因组学的理解、态度和看法。方法阿布扎比、迪拜和北阿联酋社区药房的专业人员参与了横断面研究设计。从 2023 年 7 月到 2024 年 2 月,5 名药剂学专业的最后一年学生进行了调查。研究小组采用了结构化问卷来收集数据,此外还进行了面谈。研究问卷包括三个不同的部分,即人口统计学信息、药物基因组学概念知识和对药物基因组学的看法。药剂师对药物基因组学的平均认知度为 75.1%,95% 置信区间(CI)为[72.4%, 77.7%]。对药物基因组学的态度平均得分为 67.5%,95% 置信区间为 [66.3%, 68.7%]。以下几组人对药物基因组学的了解程度更高:独立药房(OR 1.7;95 % CI 1.2-2.4)、主管药剂师(OR 1.4;95 % CI 1.3-2.02)、拥有 11-15 年工作经验的药剂师(OR 2.1;95 % CI 1.4-4.2)、国际大学毕业生(OR 4.6;95 % CI 1.6-12.9)以及接受过药物基因组学培训的人(OR 11.9;95 % CI 3.3-14.5)。同样,在独立药房(OR 1.5;95 % CI 1.1-2.1)、主管药剂师(OR 1.5;95 % CI 1.07-2.1)、拥有 16-20 年经验的药剂师(OR 2.1;95 % CI 1.16-3.7)、地区性大学毕业生(OR 1.47;95 % CI 1.05-2.1)和接受过药物基因组学培训的药剂师(OR 11.9;95 % CI 3.3-14.5)中也观察到了较好的态度评分。结论我们在研究中发现的对药物基因组学的积极态度表明,阿拉伯联合酋长国的社区药剂师开始意识到药物基因组学在改善患者护理方面的潜在优势。考虑到保险公司和潜在雇主对基因检测结果可用性的担忧,确保基因信息隐私和保密性的政策也是必要的。
{"title":"Empowering precision medicine: Insights from a national survey on pharmacogenomics knowledge, attitudes, and perceptions among community pharmacists in the UAE","authors":"Ammar Abdulrahman Jairoun ,&nbsp;Sabaa Saleh Al-Hemyari ,&nbsp;Moyad Shahwan ,&nbsp;Mena Al-Ani ,&nbsp;Mustafa Aal Yaseen ,&nbsp;Mahmood H. Al-Aawad ,&nbsp;Ghala Rashid Alnuaimi ,&nbsp;B. Mahalakshmi","doi":"10.1016/j.rcsop.2024.100508","DOIUrl":"10.1016/j.rcsop.2024.100508","url":null,"abstract":"<div><h3>Background</h3><div>Community pharmacists are essential to pharmacogenomics implementation because they can help trainers, clinical advisors, and other medical professionals understand the importance of pharmacogenomics and encourage them to use it in their practice. This study is to evaluate the community pharmacists' understanding, attitudes, and perceptions of pharmacogenomics in the United Arab Emirates (UAE).</div></div><div><h3>Methods</h3><div>Professionals employed at community pharmacies in Abu Dhabi, Dubai, and the Northern Emirates participated in a cross-sectional study design. From July 2023 to February 2024, five pharmacy students in their last year conducted the survey. The study team employed a structured questionnaire to collect data in addition to conducting in-person interviews. The study questionnaire comprised three distinct sections namely, demographic information, knowledge of pharmacogenomics concepts, and perceptions regarding pharmacogenomics.</div></div><div><h3>Results</h3><div>A total of 586 pharmacists enrolled in the study. The average knowledge score regarding pharmacogenomics was 75.1 % with a 95 % confidence interval (CI) of [72.4 %, 77.7 %]. The average attitude score toward pharmacogenomics was 67.5 % with a 95 % CI of [66.3 %, 68.7 %]. Better pharmacogenomics knowledge among several groups: independent pharmacies (OR 1.7; 95 % CI 1.2–2.4), Pharmacists in Charge (OR 1.4; 95 % CI 1.3–2.02), pharmacists with 11–15 years of experience (OR 2.1; 95 % CI 1.4–4.2), graduates from international universities (OR 4.6; 95 % CI 1.6–12.9), and those who received training on pharmacogenomics (OR 11.9; 95 % CI 3.3–14.5). Similarly, better attitude scores were observed among independent pharmacies (OR 1.5; 95 % CI 1.1–2.1), Pharmacists in Charge (OR 1.5; 95 % CI 1.07–2.1), pharmacists with 16–20 years of experience (OR 2.1; 95 % CI 1.16–3.7), graduates regional universities (OR 1.47; 95 % CI 1.05–2.1), and those who received training on pharmacogenomics (OR 4.8; 95 % CI 3.2–7.3).</div></div><div><h3>Conclusion</h3><div>The positive attitudes toward pharmacogenomics that we found in our research indicate that community pharmacists in the United Arab Emirates are beginning to realize the potential advantages of pharmacogenomics in terms of improving patient care. Policies ensuring the privacy and confidentiality of genetic information are also necessary in considering concerns about the availability of genetic test results to insurance companies and potential employers.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100508"},"PeriodicalIF":1.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667276624001057/pdfft?md5=625218b46de6b74959c05f84dba93308&pid=1-s2.0-S2667276624001057-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appropriateness of direct oral anticoagulant dosing in patients with atrial fibrillation at a tertiary care hospital in Thailand 泰国一家三级医院心房颤动患者直接口服抗凝剂剂量的适当性
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-11 DOI: 10.1016/j.rcsop.2024.100507
Chayanat Pongsathabordee , Piyachat Saringkarn , Kanjana Ratanapornsompong , Ratiya Rungruang , Saranporn Srithonrat , Pimlada Tangkaotong , Salintip Sena , Taniya Paiboonvong

Background

Appropriate dosing of direct oral anticoagulants (DOACs) has been associated with clinical efficacy and safety. Several studies have shown that DOAC dosing are often inconsistent with guideline recommendations. Little is known about this issue in Thailand. This study aimed to evaluate the appropriateness of DOAC dosing in Thai hospitalized patients with atrial fibrillation (AF).

Method

This was a retrospective descriptive study conducted on hospitalized patients at Rajavithi Hospital, a tertiary care hospital in Thailand. Inpatients diagnosed with AF and treated with DOACs between February 2021 and February 2023 were enrolled in the study. The appropriate dosing of DOACs was assessed according to the recommendation of the 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (EHRA). Descriptive statistics were used to analyze the data; median (interquartile range) for continuous variables, and numbers and percentages for categorical variables.

Results

A total of 120 patients with AF were evaluated for dosing. The patients received rivaroxaban in 47 cases (39.2 %), apixaban in 32 cases (26.7 %), edoxaban in 31 cases (25.8 %), and dabigatran in 10 cases (8.3 %). Most of the patients were elderly, with a median age of 77.5 (68–84) years. Females were predominant (57.5 %). Our findings indicate that the prevalence of appropriate dosing of DOACs was 63.3 %. However, approximately one-third of patients received inappropriate dosing, with 24 (20.0 %) being overdosed, and 20 (16.7 %) being underdosed. The highest overdosing and underdosing rates were seen in dabigatran (90.0 %) and apixaban (21.9 %), respectively.

Conclusion

Inappropriate dosing of DOACs according to the 2021 EHRA recommendations was high in 36.7 %, with overdosing mostly occurring in 20.0 %. The high number of inappropriate dosing highlights the need for implementation of optimal strategies to select the appropriate dose of DOACs in Thai hospitalized patients with AF.

背景直接口服抗凝药(DOAC)的适当剂量与临床疗效和安全性有关。多项研究表明,DOAC 的剂量往往与指南建议不一致。在泰国,人们对这一问题知之甚少。本研究旨在评估泰国住院心房颤动(房颤)患者 DOAC 剂量的适当性。研究对象为 2021 年 2 月至 2023 年 2 月期间确诊为房颤并接受 DOACs 治疗的住院患者。根据《2021 年欧洲心脏节律协会心房颤动患者使用非维生素 K 拮抗剂口服抗凝药实用指南》(EHRA)的建议,对 DOACs 的适当剂量进行了评估。数据分析采用描述性统计;连续变量采用中位数(四分位间距),分类变量采用数字和百分比。其中利伐沙班 47 例(39.2%),阿哌沙班 32 例(26.7%),埃多沙班 31 例(25.8%),达比加群 10 例(8.3%)。大多数患者为老年人,中位年龄为 77.5(68-84)岁。女性占多数(57.5%)。我们的研究结果表明,DOACs 合理用药率为 63.3%。然而,约有三分之一的患者用药不当,其中 24 人(20.0%)用药过量,20 人(16.7%)用药不足。达比加群(90.0%)和阿哌沙班(21.9%)的用药过量率和用药不足率最高。不适当用药的比例很高,这凸显了在泰国住院的房颤患者中实施选择适当剂量 DOACs 的最佳策略的必要性。
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引用次数: 0
Development of a medication review intervention by seconding a hospital pharmacist to primary care 通过向基层医疗机构借调一名医院药剂师,制定药物审查干预措施
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-10 DOI: 10.1016/j.rcsop.2024.100505
Sara Sommer Holst , Johanne Mølby Hansen , Susanne Kaae , Charlotte Vermehren

Background

Medication reviews (MRs) are a well-described initiative that improves health outcomes for polypharmacy patients. However, there is limited knowledge about the performance of medication reviews carried out in general practice especially under the leadership of hospital clinical pharmacists. When developing complex interventions, such as MRs, it is essential to describe the development process to ensure transparency and avoid research waste.

Objective

Thus, this study aimed to describe the steps of developing a new MR intervention targeting general practice to ensure transparency and transferability.

Methods

A stepwise approach inspired by the Medical Research Council framework was utilised in the process, covering two of the phases, i.e., development and feasibility, divided into four steps: 1) intervention drafting by a literature search, 2) expert opinion, 3) pilot testing in general practice clinics, and 4) evaluation of quantitative MR data.

Results

Based on the results from the first three steps, four main themes which influenced the success of the MR intervention were identified: general practitioner resources, patient involvement, implementation difficulties and interdisciplinarity. These themes guided the pilot evaluation in step four.

Conclusion

A new feasible, complex MR intervention utilising clinical pharmacists in general practice involving hospital clinical pharmacists in a real-life setting was developed.
背景用药回顾(MRs)是一项可改善多药合用患者健康状况的措施,已得到了广泛应用。然而,人们对全科医生,尤其是在医院临床药师领导下开展的用药点评的绩效了解有限。因此,本研究旨在描述针对全科实践开发新的 MR 干预措施的步骤,以确保其透明度和可转让性。方法在此过程中采用了受医学研究委员会框架启发的循序渐进法,涵盖其中的两个阶段,即开发和可行性,分为四个步骤:结果根据前三个步骤的结果,确定了影响 MR 干预成功的四大主题:全科医生资源、患者参与、实施困难和跨学科性。这些主题为第四步的试点评估提供了指导。结论利用全科临床药师和医院临床药师在现实生活中开展了一项新的可行、复杂的 MR 干预活动。
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引用次数: 0
Comparing nursing medication rounds before and after implementation of automated dispensing cabinets: A time and motion study 实施自动配药柜前后护理人员巡视用药情况的比较:时间与运动研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2024-09-07 DOI: 10.1016/j.rcsop.2024.100504
Emma Jeffrey , Áine Walsh , Joseph Hague , Kit Lai

Nursing medication administration is an integral, albeit time consuming component of a nursing shift. Automated dispensing cabinets (ADCs) are a medicines management solution designed to improve both efficiency and patient safety. This study aimed to evaluate the time taken to undertake a medication round including the number of locations visited to retrieve medicines, across four different clinical specialties within one hospital. Studies to date have investigated the effect of ADCs on nursing medication rounds centred around one clinical specialty, in hospitals with varying levels of digital maturity. This study adds to the existing body of evidence by investigating multiple clinical specialties where EPMA in use throughout the study period. In this study, prior to ADC implementation nurses retrieved required medicines from shelves in the medication room, mobile medication carts, and patients' own drug (POD) lockers. Post-ADC implementation, medicines were retrieved exclusively from the ADC and POD lockers only. Nurses were observed on each ward completing medication rounds, using the data collection tool designed for this study. Pre-implementation data was collected between February and June 2023, and post-implementation data collected between July and September 2023. There was a statistically significant reduction in the time required for medicines retrieval on the surgical ward only, post- ADC implementation. The time taken to retrieve each medication went from a mean of 98.1 s to 47.2 s (p = 0.0255). When comparing all four specialties as a whole, there was a reduction in the mean time required to issue each medicine preversus post-ADC implementation, from 83.3 s to 62.6 s respectively, however this difference was not shown to be statistically significant. The mean number of locations visited to obtain all required medicines for each patient reduced significantly from 1.73 to 1.04 (p < 0.01). There is potential for improved efficiency as nurses become more familiar with new workflows. It may be of benefit to repeat this study to ascertain whether time savings have been further improved.

护理人员的用药管理是护理工作中不可或缺的一部分,尽管非常耗时。自动配药柜 (ADC) 是一种药品管理解决方案,旨在提高效率和患者安全。本研究旨在评估一家医院内四个不同临床专科进行一次药品巡视所需的时间,包括巡视取药地点的数量。迄今为止的研究都是围绕一个临床专科,在数字化成熟度不同的医院中调查 ADC 对护理用药巡视的影响。本研究通过调查在整个研究期间使用 EPMA 的多个临床专科,对现有证据进行了补充。在这项研究中,在 ADC 实施之前,护士从药品室的货架、移动药品车和患者自备药品(POD)柜中提取所需药品。实施 ADC 后,药品只从 ADC 和 POD 储物柜中提取。使用为本研究设计的数据收集工具,观察护士在每个病房完成药物巡视的情况。实施前的数据收集时间为 2023 年 2 月至 6 月,实施后的数据收集时间为 2023 年 7 月至 9 月。实施 ADC 后,仅外科病房的取药时间在统计学上有了显著减少。检索每种药物所需的时间从平均 98.1 秒减少到 47.2 秒(p = 0.0255)。如果将所有四个专科作为一个整体进行比较,在实施 ADC 之前和之后,发放每种药品所需的平均时间分别从 83.3 秒减少到 62.6 秒,但这一差异在统计学上并不显著。为每名患者获取所有所需药品而走访的平均地点数从 1.73 个大幅减少到 1.04 个(p < 0.01)。随着护士越来越熟悉新的工作流程,效率有可能得到提高。重复这项研究以确定是否进一步节省了时间,可能会有所裨益。
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引用次数: 0
期刊
Exploratory research in clinical and social pharmacy
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