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Barriers and facilitators for pharmacist-led vaccination services: A systematic review using the Consolidated Framework for Implementation Research (CFIR) 药剂师主导的疫苗接种服务的障碍和促进因素:使用实施研究综合框架(CFIR)的系统综述
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.rcsop.2025.100687
Meral Abdulselam , Alla El-Awaisi , Ziad G. Nasr , Shahd Shaar , Maguy Saffouh El Hajj

Background

Pharmacists are well positioned to contribute to the expansion of vaccination program outreach, owing to their high accessibility, pharmacotherapy knowledge, and patient-centered services. Over the past decade, the scope of pharmacy practice has progressively evolved, shifting from a product-oriented role toward more direct involvement in public health initiatives, including immunization. Despite this advancement, the full potential of pharmacists as immunization providers remains underutilized due to several barriers.

Objective

This systematic review aims to synthesize evidence on the barriers and facilitators of pharmacist-led vaccination services using the Consolidated Framework for Implementation Research (CFIR).

Method

A comprehensive literature search was conducted across multiple databases (Ovid/Medline, EMBASE, ISI Web of Science, ProQuest Dissertations, PROSPERO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Elsevier Science Direct, Health Management Information Consortium (HMIC), and Google Scholar. Studies were included if they focused on pharmacist-initiated vaccinations and reported relevant barriers or facilitators. The findings were mapped to CFIR.

Results

A total of 33 studies were included. Barriers to pharmacist-led vaccination services were reported in 32 studies. The main barriers in the Outer Domain were mainly fear of conflicting roles with physicians and public attitudes, lack of physician support, patient unwillingness to receive vaccinations in community settings, liability and regulation related issues, and reimbursement for pharmacist vaccination services. In the Inner Domain, lack of pharmacist training and lack of adequate facilities for delivering community pharmacy vaccination services were the main barriers. Facilitators in the Outer Domain were professional recognition, cooperation between pharmacists and healthcare centers, and financial remuneration. In the Inner Domain, immunization training was frequently considered as a crucial element. Under the Individual Characteristics Domain, opportunities to strengthen the pharmacist–patient relationship, pharmacist interest, patient trust, and patient demand were considered as key facilitators.

Conclusion

This study identified the main barriers and facilitators to pharmacist-led vaccination services using the CFIR framework, primarily within the Outer and Inner Setting domains. Findings highlight the need for targeted training, regulatory support, and reorganized reimbursement. Future research should explore context-specific interventions and evaluate training effectiveness to advance pharmacist-led immunization.
药剂师由于其高可及性、药物治疗知识和以患者为中心的服务,在扩大疫苗接种计划外展方面处于有利地位。在过去十年中,药房的业务范围逐步发展,从以产品为导向的角色转向更直接地参与公共卫生行动,包括免疫接种。尽管取得了这一进展,但由于一些障碍,药剂师作为免疫提供者的全部潜力仍未得到充分利用。目的:本系统综述旨在利用实施研究统一框架(CFIR)综合有关药剂师主导的疫苗接种服务的障碍和促进因素的证据。方法在多个数据库(Ovid/Medline、EMBASE、ISI Web of Science、ProQuest Dissertations、PROSPERO、Cumulative Index to Nursing and Allied Health literature (CINAHL)、Elsevier Science Direct、Health Management Information Consortium (HMIC)和谷歌Scholar)中进行综合文献检索。如果研究的重点是药剂师发起的疫苗接种,并报告了相关的障碍或促进因素,则纳入研究。研究结果被映射到CFIR。结果共纳入33项研究。32项研究报告了药剂师主导的疫苗接种服务存在的障碍。外域的主要障碍主要是害怕与医生的角色冲突和公众态度,缺乏医生的支持,患者不愿意在社区环境中接受疫苗接种,责任和监管相关问题,以及药剂师疫苗接种服务的报销。在内陆地区,缺乏药剂师培训和缺乏提供社区药房疫苗接种服务的适当设施是主要障碍。外域的促进因素包括专业认可、药师与医疗中心的合作以及财务报酬。在内在领域,免疫训练经常被认为是一个关键因素。在个体特征领域,加强医患关系、药师利益、患者信任和患者需求的机会被认为是关键的促进因素。本研究确定了使用CFIR框架的药剂师主导的疫苗接种服务的主要障碍和促进因素,主要是在外部和内部设置领域。研究结果强调了有针对性的培训、监管支持和重组报销的必要性。未来的研究应探索针对具体情况的干预措施,并评估培训效果,以推进药剂师主导的免疫接种。
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引用次数: 0
Improved persistence to statin therapy through a patient counseling intervention in community pharmacies – A nationwide cohort study 通过社区药房患者咨询干预提高他汀类药物治疗的持久性-一项全国性队列研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-03-01 Epub Date: 2025-12-22 DOI: 10.1016/j.rcsop.2025.100699
Karin Svensberg , Björn Wettermark , Jenna Ramsin Eklund , Mohammadhossein Hajiebrahimi , Marie Ekenberg , Albin Tranberg , Sofia Kälvemark Sporrong

Background

Poor adherence is a well-known problem for statins, key medicines for reducing cardiovascular morbidity and mortality. Community pharmacy services have been identified as a way to increase adherence. We assessed the effect of motivating counseling in Swedish community pharmacies on treatment persistence in patients starting statin therapy.

Methods

In this cohort study, one-year persistence was evaluated in patients who initiated statin therapy (ATC C10AA) between October 2022 and June 2023 following pharmacy-based counseling, and compared with five age- and sex-matched controls per patient from pharmacies not providing the service. Data were collected from Swedish national health registers on dispensed medications, diagnoses and socioeconomic characteristics of patients. Odds ratios for being persistent with 95 % confidence intervals were calculated using a logistic regression model adjusted for socioeconomics, cardiovascular comorbidity and pharmacy size.

Results

A total of 902 patients who had data available in the Swedish national registers received the intervention. They had a higher education and income, mostly Swedish born and they had less history of cardiovascular disease, compared to the 4510 age- and sex-matched controls. The one-year persistence was significantly higher among those who received the service compared to controls (80.2 % compared to 73.6 %). Adjusted odds ratios for being persistent after the intervention was 1.43 (95 % CI 1.19–1.71).

Conclusion

Patients who receive a motivating counseling service in community pharmacies have a higher persistence to statin treatment, one year after initiation, after adjustment for differences in patient characteristics.
作为降低心血管疾病发病率和死亡率的关键药物,他汀类药物的依从性差是一个众所周知的问题。社区药房服务已被确定为增加依从性的一种方式。我们评估了瑞典社区药房的激励咨询对开始他汀类药物治疗的患者治疗持久性的影响。方法在这项队列研究中,评估了在2022年10月至2023年6月期间接受药物咨询后开始他汀类药物治疗(ATC C10AA)的患者一年的持续性,并与来自未提供该服务的药店的5名患者进行了年龄和性别匹配的对照。从瑞典国家卫生登记中收集了关于分配的药物、诊断和患者的社会经济特征的数据。使用经社会经济学、心血管合并症和药房规模调整后的逻辑回归模型计算持久性的优势比,置信区间为95%。结果共有902例瑞典国家登记数据的患者接受了干预。与4510名年龄和性别匹配的对照组相比,他们受教育程度和收入都较高,大多出生在瑞典,心血管疾病史较少。与对照组相比,接受这项服务的人一年的持久性明显更高(80.2%比73.6%)。干预后持续治疗的校正优势比为1.43 (95% CI 1.19-1.71)。结论在社区药房接受激励性咨询服务的患者在调整患者特征差异后,对他汀类药物治疗的坚持度较高。
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引用次数: 0
Prescription-only medicine requests by clients: Insights from community pharmacies 客户的处方药物要求:来自社区药房的见解
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-03-01 Epub Date: 2025-12-03 DOI: 10.1016/j.rcsop.2025.100689
Chabiya Ayuba Tashiwa , Erick Wesley Hedima

Background

The accessibility of community pharmacies increases the likelihood that patients will approach pharmacists for medication needs, including those that require prescriptions. This study assessed prescription medicine requests from members of the public. Method This study employed a cross-sectional design to investigate clients seeking medication from community pharmacies in Karu, Nasarawa State, Nigeria. Data were collected using a validated questionnaire comprising of two sections. Chi-square or Fisher's exact tests, where appropriate, were utilized to determine factors associated with prescription-only medicine (POM) requests. Associations between perception scores and patient characteristics were analyzed using the Mann-Whitney U test or Kruskal-Wallis test. Logistic regression analysis was employed to identify factors that may elucidate the correlates of obtaining medicines without a prescription. Statistical significance was set at p < 0.05 (95 % CI).

Results

A total of 258 adults with access to prescription-only (POM) or over-thecounter (OTC) medications were included in the study. The prevalence of prescription medicine request was 53 %. Headaches, fever, pain, and dysmenorrhea were the most frequent complaints (33.9 %). A significant difference was observed between medicineseeking practices and chronic illnesses (p = 0.01). The odds of requesting a POM decreased with lower educational attainment (AOR 0.05; 95 % CI, 0.06–0.43). While Age (p = 0.006), employment status (p = 0.03), and monthly income (p = 0.01) were significantly associated with perception of medication-seeking behavior. The most commonly requested medicine was artemether and lumefantrine, accounting for 12.3 % of prescriptions. Most respondents agreed that consultation with a registered medical practitioner for any health concern is necessary.

Conclusion

The prevalence of prescription-only medicine requests by clients seeking healthcare from community pharmacies was relatively high. Artemether/lumefantrine and amoxicillin/clavulanate were the most sought medicines. Strengthen national prescribing policies by granting pharmacists structured prescribing authority, thereby promoting accountability and the rational use of medicines.
社区药房的可及性增加了患者向药剂师寻求药物需求的可能性,包括那些需要处方的药物。这项研究评估了公众对处方药的要求。方法本研究采用横断面设计对尼日利亚纳萨拉瓦州卡鲁社区药房求医的顾客进行调查。数据收集使用有效的问卷调查,包括两个部分。在适当的情况下,使用卡方检验或Fisher精确检验来确定与处方药物(POM)请求相关的因素。使用Mann-Whitney U检验或Kruskal-Wallis检验分析感知评分与患者特征之间的关系。采用Logistic回归分析来确定可能阐明无处方获得药物的相关因素。p < 0.05 (95% CI)具有统计学意义。结果共有258名获得处方(POM)或非处方(OTC)药物的成年人被纳入研究。处方用药请求率为53%。头痛、发热、疼痛和痛经是最常见的主诉(33.9%)。就诊行为与慢性疾病有显著性差异(p = 0.01)。要求POM的几率随着受教育程度的降低而降低(AOR 0.05; 95% CI, 0.06-0.43)。年龄(p = 0.006)、就业状况(p = 0.03)和月收入(p = 0.01)与就医行为感知显著相关。用药最多的是蒿甲醚和苯丙啶,占处方的12.3%。大多数答复者同意,就任何健康问题向注册医生咨询是必要的。结论在社区药房就诊的患者中,单处方用药的比例较高。甲醚/氨苯曲明和阿莫西林/克拉维酸是最常寻求的药物。加强国家处方政策,赋予药剂师结构化的处方权,从而促进问责制和合理用药。
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引用次数: 0
Prevalence and determinants of unused medicines among households in Ethiopia: A systematic review and meta-analysis 埃塞俄比亚家庭中未使用药物的流行情况和决定因素:系统回顾和荟萃分析
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-07-31 DOI: 10.1016/j.rcsop.2025.100639
Tekletsadik Tekleslassie Alemayehu , Gebremariam Wulie Geremew , Eskedar Dires Gebremeskel , Zemenu Wube Bayleyegn , Ayelign Eshete Fitgu , Tefera Minwagaw , Mulugojjam Jegnie Tagele , Rahel Belete Abebe , Tirsit Ketsela Zeleke , Abaynesh Fentahun Bekalu , Masho Tigabie Tekle , Mekonnen Derese Mekete , Mulugeta Assefa Estifo , Abebech Tewabe Gelaye , Tadele Mesfin Demelash , Fraol Zeleke Desta , Elsabeth Alemayehu Haile , Simon Zemenfes Hailu , Adugna Tadesse Gemeda , Tesfaye Birhanu Abebe

Background

Unused medicines present significant public health, environmental risks and economic challenges. Understanding their prevalence and determinants is crucial for designing appropriate interventions. This systematic review and meta-analysis aimed to estimate the pooled prevalence and determinants of unused medicines among households in Ethiopia.

Method

A comprehensive search was conducted across major databases, including Scopus, Science Direct, Embase, PubMed/MEDLINE, Google Scholar, and Research Gate, to identify relevant studies published up to January 10, 2025. Eligible studies reporting the prevalence and determinants of unused medicines in Ethiopian households were included. Data were extracted via a Microsoft Excel spreadsheet and analyzed using STATA version 11.0, applying a random-effects model to estimate the pooled prevalence and account for heterogeneity. Subgroup and sensitivity analyses were performed to explore variations across studies.

Result

A total of 12 studies involving 6123 households were included. The pooled prevalence of unused medicines was estimated at 44.34 % (95 % CI: 32.83, 55.84), with substantial heterogeneity among studies (I2 = 99.0 %, p value =0.000). Subgroup analyses revealed higher prevalence rates in urban households at 47.8 % compared to rural households at 26.89 % and regional disparities. Antibiotics were the most frequently unused class of medications, accounting for 31.49 % of all unused medicines in households, followed by analgesics at 26.14 %, while antacids constituted 8.7 %. The primary reasons for the accumulation of unused medicines included self-discontinuation upon symptom relief at 34.21 %, while anticipation of future use constitute 20.47 %. Factors such as self-medication with NSAIDs, acquisition of medications without prescriptions, and higher household income were significantly associated with the prevalence of unused medicines among households in Ethiopia.

Conclusion

This systematic review and meta-analysis revealed that unused medicines among households in Ethiopian was prevalent, with significant regional variations. Antibiotics were the most commonly unused medications, followed by analgesics, while cardiovascular medicines and dietary supplements were the least reported. The primary reasons for the accumulation of unused medicines included self-discontinuation upon symptom relief, and anticipation of future use. Key determinants such as self-medication with NSAIDs, acquisition of medications without prescriptions, and higher household income were significantly associated with the prevalence of unused medicines. These findings underscore the need for context specific interventions to address the high prevalence of unused medicines in Ethiopia, particularly in urban settings and regions with higher rates.
使用过的药物带来了重大的公共卫生、环境风险和经济挑战。了解其流行情况和决定因素对于设计适当的干预措施至关重要。本系统综述和荟萃分析旨在估计埃塞俄比亚家庭中未使用药物的总流行率和决定因素。方法对Scopus、Science Direct、Embase、PubMed/MEDLINE、谷歌Scholar、Research Gate等主要数据库进行综合检索,确定截至2025年1月10日发表的相关研究。纳入了报告埃塞俄比亚家庭中未使用药物的流行情况和决定因素的合格研究。通过Microsoft Excel电子表格提取数据,并使用STATA 11.0版本进行分析,应用随机效应模型估计合并患病率并解释异质性。进行亚组和敏感性分析以探索研究间的差异。结果共纳入12项研究,涉及6123户家庭。未使用药物的总患病率估计为44.34% (95% CI: 32.83, 55.84),研究之间存在很大的异质性(I2 = 99.0%, p值=0.000)。亚组分析显示,城市家庭的患病率为47.8%,高于农村家庭的26.89%,而且存在地区差异。抗生素是最常被使用的一类药物,占家庭所有未使用药物的31.49%,其次是镇痛药,占26.14%,而抗酸药占8.7%。未用药物积累的主要原因是症状缓解后自行停药,占34.21%,预期再次用药占20.47%。在埃塞俄比亚,使用非甾体抗炎药自我药疗、在没有处方的情况下获得药物以及较高的家庭收入等因素与家庭中未使用药物的流行程度显著相关。本系统综述和荟萃分析显示,埃塞俄比亚家庭中未使用药物的情况普遍存在,且存在显著的地区差异。抗生素是最常见的未使用药物,其次是镇痛药,而心血管药物和膳食补充剂的报告最少。未使用药物积累的主要原因包括症状缓解后自行停药和预期将来使用。关键决定因素,如非甾体抗炎药自我药疗、无需处方获得药物以及较高的家庭收入与未使用药物的流行率显著相关。这些发现强调需要针对具体情况采取干预措施,以解决埃塞俄比亚,特别是在城市环境和使用率较高的地区未使用药物的高流行率问题。
{"title":"Prevalence and determinants of unused medicines among households in Ethiopia: A systematic review and meta-analysis","authors":"Tekletsadik Tekleslassie Alemayehu ,&nbsp;Gebremariam Wulie Geremew ,&nbsp;Eskedar Dires Gebremeskel ,&nbsp;Zemenu Wube Bayleyegn ,&nbsp;Ayelign Eshete Fitgu ,&nbsp;Tefera Minwagaw ,&nbsp;Mulugojjam Jegnie Tagele ,&nbsp;Rahel Belete Abebe ,&nbsp;Tirsit Ketsela Zeleke ,&nbsp;Abaynesh Fentahun Bekalu ,&nbsp;Masho Tigabie Tekle ,&nbsp;Mekonnen Derese Mekete ,&nbsp;Mulugeta Assefa Estifo ,&nbsp;Abebech Tewabe Gelaye ,&nbsp;Tadele Mesfin Demelash ,&nbsp;Fraol Zeleke Desta ,&nbsp;Elsabeth Alemayehu Haile ,&nbsp;Simon Zemenfes Hailu ,&nbsp;Adugna Tadesse Gemeda ,&nbsp;Tesfaye Birhanu Abebe","doi":"10.1016/j.rcsop.2025.100639","DOIUrl":"10.1016/j.rcsop.2025.100639","url":null,"abstract":"<div><h3>Background</h3><div>Unused medicines present significant public health, environmental risks and economic challenges. Understanding their prevalence and determinants is crucial for designing appropriate interventions. This systematic review and meta-analysis aimed to estimate the pooled prevalence and determinants of unused medicines among households in Ethiopia.</div></div><div><h3>Method</h3><div>A comprehensive search was conducted across major databases, including Scopus, Science Direct, Embase, PubMed/MEDLINE, Google Scholar, and Research Gate, to identify relevant studies published up to January 10, 2025. Eligible studies reporting the prevalence and determinants of unused medicines in Ethiopian households were included. Data were extracted via a Microsoft Excel spreadsheet and analyzed using STATA version 11.0, applying a random-effects model to estimate the pooled prevalence and account for heterogeneity. Subgroup and sensitivity analyses were performed to explore variations across studies.</div></div><div><h3>Result</h3><div>A total of 12 studies involving 6123 households were included. The pooled prevalence of unused medicines was estimated at 44.34 % (95 % CI: 32.83, 55.84), with substantial heterogeneity among studies (I<sup>2</sup> = 99.0 %, <em>p</em> value =0.000). Subgroup analyses revealed higher prevalence rates in urban households at 47.8 % compared to rural households at 26.89 % and regional disparities. Antibiotics were the most frequently unused class of medications, accounting for 31.49 % of all unused medicines in households, followed by analgesics at 26.14 %, while antacids constituted 8.7 %. The primary reasons for the accumulation of unused medicines included self-discontinuation upon symptom relief at 34.21 %, while anticipation of future use constitute 20.47 %. Factors such as self-medication with NSAIDs, acquisition of medications without prescriptions, and higher household income were significantly associated with the prevalence of unused medicines among households in Ethiopia.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis revealed that unused medicines among households in Ethiopian was prevalent, with significant regional variations. Antibiotics were the most commonly unused medications, followed by analgesics, while cardiovascular medicines and dietary supplements were the least reported. The primary reasons for the accumulation of unused medicines included self-discontinuation upon symptom relief, and anticipation of future use. Key determinants such as self-medication with NSAIDs, acquisition of medications without prescriptions, and higher household income were significantly associated with the prevalence of unused medicines. These findings underscore the need for context specific interventions to address the high prevalence of unused medicines in Ethiopia, particularly in urban settings and regions with higher rates.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"20 ","pages":"Article 100639"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a medication safety self-assessment tool for high-alert medications in community pharmacies 开发社区药房高危药物用药安全自我评估工具
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI: 10.1016/j.rcsop.2025.100664
Rositsa Koleva , Anita Währn , Ercan Celikkayalar , Sonja Kallio , Raisa Laaksonen

Background

High-alert medications are recognised as those carrying heightened risk of causing significant patient harm when used erroneously.

Objective

To develop a high-alert medications self-assessment tool for Finnish community pharmacies.

Methods

The tool was developed using a three-phase Delphi method and is based on the Institute for Safe Medication Practices´ Medication Safety Self Assessment® for High-Alert Medications, which comprises 380 items. A pre-Delphi round was first conducted to assess tool's applicability for Finnish pharmacies, followed by two Delphi rounds with a multidisciplinary expert panel evaluating the applicability and desirability of each item. A consensus rate of 70 % was defined. Following the Delphi rounds, the tool was finalized through refinement, removal of duplicates, and reorganization.

Results

Consensus was reached on 114 items, resulting in a finalized self-assessment tool organized into eight sections covering medicine groups such as insulin and oral diabetes medicines, anticoagulants, opioids, immunosuppressants, methotrexate, and over-the-counter high-alert medications. After the first Delphi round, 33 items were accepted without changes and 97 were revised. After the second Delphi round, 77 items were transferred to the final tool as such, 35 were modified and 21 were removed.

Conclusion

The developed high-alert self-assessment tool offers a structured method for evaluating existing practices and implementing targeted safety measures, addressing a specific need in community pharmacies, where such resources are limited. While further validation and implementation research are needed, the tool represents a practical step toward enhancing medication safety and promoting continuous improvement in pharmacy practice.
背景:高警戒性药物被认为是那些在使用错误时对患者造成重大伤害的高风险药物。目的开发芬兰社区药房高警惕性用药自我评估工具。方法该工具采用三阶段德尔菲法开发,基于美国安全用药实践研究所的“高度警戒药物用药安全自我评估®”,包含380个项目。首先进行了德尔菲前一轮评估工具对芬兰药房的适用性,随后进行了两轮德尔菲,由多学科专家小组评估每个项目的适用性和可取性。共识率为70%。在Delphi轮之后,该工具通过改进、删除重复和重组完成。结果在114个项目上达成共识,最终形成了一个自我评估工具,分为8个部分,涵盖了胰岛素和口服糖尿病药物、抗凝血剂、阿片类药物、免疫抑制剂、甲氨蝶呤和非处方高警惕性药物等药物组。经过第一轮德尔菲评审,33个项目未作修改,97个项目进行了修改。在第二次德尔菲轮后,77个项目被转移到最终工具中,35个被修改,21个被删除。结论开发的高警惕性自我评估工具为评估现有做法和实施有针对性的安全措施提供了一种结构化的方法,解决了资源有限的社区药房的特定需求。虽然需要进一步的验证和实施研究,但该工具代表了加强用药安全性和促进药学实践持续改进的实际步骤。
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引用次数: 0
Incorporating patient preference into as needed pain orders at a large academic health system 在一个大型学术卫生系统中,将患者偏好纳入必要的疼痛指令
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-09-07 DOI: 10.1016/j.rcsop.2025.100654
Meghan D. McNulty , Michael E. Guerra, Kristina Shvets, Philip Rosselli, Adam L. Ackerman, Roberta Chuong , Jessie Riemer

Background

Joint Commission Accreditation Surveys at multiple hospitals within the Yale New Haven Health System (YNHHS) revealed that patients often requested lower doses and/or lower potencies of as needed (PRN) pain medications than those ordered for their reported pain score. This resulted in the potential for PRN pain medications to be given without a proper order or risking a delay in care while waiting for a new medication order to be placed by a clinician. This project followed the requirements set forth by The Joint Commission to seamlessly integrate patient preferences into the health system electronic health record (EHR) to enhance patient care and reduce unnecessary opioid consumption.

Methods

Two Joint Commission Standards that provided project guidance were PC.01.02.07 (the hospital manages and assesses patient pain while minimizing risks) and MM.04.01.01 (medication orders are clear and accurate). Implementing the proposal involved modifying the existing PRN pain orders and the Medication Administration Record (MAR) and updating the YNHHS Pain Assessment and Management policy. Education was developed and shared with clinicians, nursing, and pharmacy, along with a Tips and Tricks document for this newly developed workflow.

Results

The project successfully enhanced utilization of as needed pain medication orders through incorporation of patient preference options into PRN pain medication orders. Feedback after implementation from clinicians and nursing staff was also positive.

Conclusions

This project successfully demonstrates how large academic health systems can incorporate patient preference into PRN pain orders.
在耶鲁纽黑文医疗系统(YNHHS)内的多家医院进行的联合委员会认证调查显示,患者通常要求按需(PRN)止痛药的剂量和/或效力低于他们报告的疼痛评分。这导致了在没有适当的处方的情况下给PRN止痛药的可能性,或者在等待临床医生开出新的药物处方时冒着延误护理的风险。该项目遵循联合委员会提出的要求,将患者偏好无缝整合到卫生系统电子健康记录(EHR)中,以加强患者护理并减少不必要的阿片类药物消耗。方法提供项目指导的两项联委会标准分别为PC.01.02.07(医院在降低风险的同时管理和评估患者疼痛)和MM.04.01.01(医嘱清晰准确)。实施该提案涉及修改现有的PRN疼痛单和药物管理记录(MAR),并更新YNHHS疼痛评估和管理政策。开发了教育,并与临床医生、护理和药房共享,同时还为这个新开发的工作流程编写了一份提示和技巧文档。结果通过将患者偏好选项纳入PRN镇痛药单,成功提高了按需镇痛药单的使用率。实施后临床医生和护理人员的反馈也是积极的。该项目成功地展示了大型学术卫生系统如何将患者偏好纳入PRN疼痛订单。
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引用次数: 0
Longitudinal study on the seasonal variation in methylphenidate consumption in the South African private healthcare sector 南非私营医疗保健部门哌甲酯消费季节性变化的纵向研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-11-03 DOI: 10.1016/j.rcsop.2025.100680
Ilse Truter, Ashmitha Munasur-Naidoo

Background

A steady growth in the consumption of medicine for Attention-Deficit/Hyperactivity Disorder (ADHD) has been evident over the past two decades. The Coronavirus disease 2019 (COVID-19) pandemic is reported to have had an effect on stimulant consumption. Methylphenidate is the main active ingredient used in the treatment of ADHD, both in children and adults.

Objective

The primary aim was to analyze the consumption patterns of methylphenidate in the private healthcare sector in South Africa by means of a drug utilization study using the Defined Daily Dose (DDD) methodology to establish trends, detect seasonal variations and to compare the results with international studies.

Methods

A retrospective descriptive drug utilization study was conducted. IQVIA sales data from the South African private healthcare sector from 2013 to 2023 were analyzed. Consumption patterns were expressed as the number of Defined Daily Doses (DDDs)/1000 inhabitants/day and DDDs/1000 inhabitants/month. Ethical approval for the study was granted.

Results

Methylphenidate consumption showed a steady increase in the years around the pandemic period, from 9.07 (in 2018) to 9.88 DDDs/1000 inhabitants/day (in 2023), with a notable lower consumption in 2020 when the COVID-19 pandemic started. Consumption in 2013 was only 6.01 DDD/1000 inhabitants/day, which indicates an increase of 64.39 % over the 11-year period. Seasonal peaks in consumption were observed in February, May, August and November, coinciding with times before assessment periods in schools and universities.

Conclusions

There was a clear visible upward trend in the consumption of methylphenidate, with a decrease during 2020, as was also observed in other countries. Similar studies are recommended for other central nervous system drug classes.
背景:在过去的二十年中,治疗注意力缺陷/多动障碍(ADHD)的药物消费量稳步增长。据报道,2019年冠状病毒病(COVID-19)大流行对兴奋剂消费产生了影响。哌甲酯是治疗儿童和成人多动症的主要有效成分。目的:主要目的是通过使用限定日剂量(DDD)方法进行药物利用研究,分析南非私营医疗保健部门哌甲酯的消费模式,以确定趋势,检测季节性变化,并将结果与国际研究进行比较。方法采用回顾性描述性药物使用研究。分析了2013年至2023年南非私人医疗保健部门的IQVIA销售数据。消费模式表示为限定日剂量(DDDs)/1000居民/天和DDDs/1000居民/月。该研究获得了伦理批准。结果在大流行期间,哌甲酯消费量呈稳步增长趋势,从2018年的9.07 DDDs/1000人/天增加到2023年的9.88 DDDs/1000人/天,而在2019冠状病毒病大流行开始的2020年,哌甲酯消费量明显下降。2013年的消费量仅为6.01 DDD/1000居民/天,11年间增长了64.39%。在2月、5月、8月和11月观察到季节性消费高峰,与学校和大学评估期之前的时间相吻合。结论与其他国家一样,2020年哌醋甲酯消费量呈明显上升趋势,呈下降趋势。其他中枢神经系统药物也建议进行类似的研究。
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引用次数: 0
A data-driven approach to optimizing waiting times in outpatient pharmacy services: Interrupted time series analysis 优化门诊药房服务等待时间的数据驱动方法:中断时间序列分析
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.rcsop.2025.100672
Hazzaa Alghamdi , Talal S. Alshihayb , Yazeed Alharbi , Mohammad Alawagi , Abdullah Aleissa , Yasser Albogami

Background

Operational efficiency in outpatient pharmacies is a critical factor in healthcare delivery, directly impacting patient satisfaction and adherence to prescribed treatments. Prolonged waiting times in pharmacies can lead to patient dissatisfaction, reduced medication adherence, and potential health risks.

Objective

This study aimed to analyze the impact of a data-driven intervention on reducing patient waiting times in an outpatient pharmacy at a tertiary hospital, with a goal of ensuring that patients are served within 30 min of ticket issuance.

Methods

The study utilized data from the “Qsmart” ticketing system, covering October 2022 to November 2023. A descriptive analysis was conducted to identify peak service hours and assess staffing patterns. An interrupted time series analysis (ITSA) was employed to evaluate the effectiveness of an intervention implemented between January 22 and February 26, 2023. The intervention included increased staffing during peak hours, adjustments to break schedules, and enhanced pre-peak hour preparations.

Results

The descriptive analysis revealed peak service hours between 9 AM and 11 AM, with the highest number of tickets issued at 10 AM. The intervention produced a significant immediate level reduction in waiting times of 0.1540 (95 %CI: 0.0421,0.2659) but there was no additional post-intervention slope change, indicating that the improvement was not progressively increasing over time.

Conclusion

The data-driven intervention effectively reduced waiting times in the outpatient pharmacy, with significant immediate improvements observed. This study highlights the potential of strategic operational adjustments to enhance service efficiency and patient satisfaction. Further research is needed to validate the sustainability and generalizability of these findings in other settings.
门诊药房的运营效率是医疗保健服务的关键因素,直接影响患者满意度和对处方治疗的依从性。在药房等待时间过长可能导致患者不满,降低服药依从性,并带来潜在的健康风险。本研究旨在分析数据驱动干预对减少三级医院门诊药房患者等待时间的影响,目标是确保患者在出票后30分钟内获得服务。该研究利用了“Qsmart”票务系统的数据,时间为2022年10月至2023年11月。进行了描述性分析,以确定高峰服务时间和评估人员配置模式。采用中断时间序列分析(ITSA)来评估2023年1月22日至2月26日实施的干预措施的有效性。干预措施包括在高峰时段增加人员配备,调整休息时间表,并加强高峰时段前的准备工作。结果描述性分析显示,高峰服务时间为上午9点至11点,上午10点开出的车票数量最多。干预产生了显著的等待时间减少0.1540 (95% CI: 0.0421,0.2659),但没有额外的干预后斜率变化,表明改善并没有随着时间的推移而逐渐增加。结论数据驱动的干预有效减少了门诊药房的等待时间,效果显著。本研究强调策略性运作调整的潜力,以提高服务效率和病人满意度。需要进一步的研究来验证这些发现在其他情况下的可持续性和普遍性。
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引用次数: 0
Exploring the experience of managers, employees, and pharmacists in clinical pharmacy in primary care using the SEIPS model: A focus group study 使用SEIPS模型探讨初级保健临床药学管理者、员工和药剂师的经验:焦点小组研究
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-09-14 DOI: 10.1016/j.rcsop.2025.100657
Karin Svensberg , Lea Axelsson , Lina Hellström

Background and aim

Medication management in primary care faces challenges that affect patient outcomes.
The inclusion of clinical pharmacists in care teams aims to address these issues. In Nordic countries, the role of clinical pharmacy services in primary care is still evolving with limited research. The Systems Engineering Initiative for Patient Safety (SEIPS) model provides a framework for evaluating healthcare systems by examining the system factors and processes that influence outcomes. This study aimed to identify factors influencing the integration and advancement of the role of pharmacists in primary care using the SEIPS model.

Methods

A focus group study was conducted with four groups (n = 17): managers, pharmacists, nurses, and general practitioners. Deductive thematic analysis guided by the SEIPS model was used to structure the data.

Results

Despite taking time to establish the pharmacist as a colleague, the participants expressed satisfaction with the collaboration and the pharmacist's role within the work system and processes at healthcare centres. Central factors for system and process development were identified, including a needs-based and structured approach to implementation, pharmacists with the right qualities and skills, teamwork, and physical presence. Perceived outcomes included increased pharmaceutical knowledge among coworkers and patients, reduced workload for staff, and improved patient safety regarding therapies.

Conclusion

Participants emphasised the potential of integrating pharmacists into primary care to address medication-management challenges. The SEIPS model provides insights into work system dynamics and can help develop the role of pharmacists in healthcare.
背景和目的初级保健的药物管理面临着影响患者预后的挑战。将临床药师纳入护理团队旨在解决这些问题。在北欧国家,临床药学服务在初级保健中的作用仍在发展,研究有限。患者安全系统工程计划(SEIPS)模型通过检查影响结果的系统因素和过程,为评估医疗保健系统提供了一个框架。本研究旨在运用SEIPS模型,探讨药师在基层医疗中角色整合与提升的影响因素。方法采用焦点小组研究,分为管理人员、药师、护士、全科医生4组(n = 17)。采用SEIPS模型指导下的演绎主题分析对数据进行结构化。结果:尽管将药剂师建立为同事需要时间,但参与者对合作以及药剂师在医疗保健中心的工作系统和流程中的作用表示满意。确定了系统和流程开发的中心因素,包括基于需求和结构化的实施方法,具有适当素质和技能的药剂师,团队合作和实际存在。可感知的结果包括增加同事和患者的药学知识,减少工作人员的工作量,提高患者对治疗的安全性。结论:与会者强调了将药剂师纳入初级保健以解决药物管理挑战的潜力。SEIPS模型提供了对工作系统动态的见解,可以帮助开发药剂师在医疗保健中的作用。
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引用次数: 0
From the patient point of view: Using eye tracking to evaluate older adult shopping behavior change with a community pharmacy OTC intervention 从患者的角度:使用眼动追踪评估老年人购物行为改变与社区药房OTC干预
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2025-12-01 Epub Date: 2025-08-19 DOI: 10.1016/j.rcsop.2025.100646
Emily L. Hoffins , Jamie A. Stone , Aaron M. Gilson , Taylor L. Watterson , Jason S. Chladek , Michelle A. Chui

Background

Over-the-counter medications are an integral component of community pharmacies, providing patients with accessible options for addressing health concerns independently. However, this increases the potential for adverse drug events, particularly among older adults, due to overestimating medication safety. Pharmacy layouts, often informed by retail store principles, frequently prioritize product profitability over patient safety.

Objective

This study evaluates the impact of Senior Safe™, a physical redesign of pharmacy aisles, on older adults' visual attention during medication selection to enhance patient safety.

Methods

Senior Safe rearranged over-the-counter products based on safety designation and human factors engineering principles. Older adult participants wore eye-tracking glasses and engaged in a scenario-based simulation to measure gaze behavior during medication selection. Simulations were conducted pre- and post-intervention to analyze fixation durations within each medication safety category.

Results

Thirty-eight older adult participants completed this portion of the study. Post-intervention participants spent significantly more time fixating on Senior Safe medications (μ = 25.17 s) compared to pre-implementation participants (μ = 9.40s). Post-intervention participants also spent more time selecting OTCs overall.

Conclusion

This study demonstrates how environmental redesign influences patient visual attention behavior. These findings emphasize the role of environmental design in enhancing patient safety and support eye-tracking as an effective method for measuring patient behavior in community pharmacy settings.
非处方药物是社区药房的一个组成部分,为患者提供可获得的选择,以独立解决健康问题。然而,这增加了药物不良事件的可能性,特别是在老年人中,由于高估了药物安全性。药房的布局,通常根据零售商店的原则,经常优先考虑产品的盈利能力,而不是患者的安全。目的:本研究旨在评估老年人在选择药物时视觉注意力的影响,以提高患者的安全性。方法基于安全标识和人因工程原理对非处方药进行重新排序。老年参与者戴着眼球追踪眼镜,参与基于场景的模拟,以测量药物选择过程中的凝视行为。在干预前和干预后进行模拟,分析每个药物安全类别的固定时间。38名老年参与者完成了研究的这一部分。干预后受试者对高级安全药物的注视时间(μ = 25.17 s)显著高于干预前受试者(μ = 9.40s)。总体而言,干预后的参与者也花了更多的时间选择otc。结论本研究揭示了环境再造对患者视觉注意行为的影响。这些研究结果强调了环境设计在提高患者安全方面的作用,并支持眼动追踪作为衡量社区药房患者行为的有效方法。
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引用次数: 0
期刊
Exploratory research in clinical and social pharmacy
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