Pub Date : 2024-02-17DOI: 10.17352/2455-8583.000064
Ilesanmi Ayodele O, Atanda Tiamiyu A, Ilesanmi Rose, Ogunniyi Tolulope J, Akinleye Waheed A
Background and aims: Diabetes Mellitus (DM) is a metabolic disorder that manifests as chronic hyperglycemia accompanied by a dysfunctional metabolism of carbohydrates, lipids, and proteins. Several studies have earlier pointed out several complications associated with the disease and in particular, the sufferer’s susceptibility to various infectious diseases. We therefore sought to investigate the adaptive immune status of the condition, as represented by the assessment of CD4+ T cell count among DM patients. Method: Seventy-six type 2 DM patients were recruited for the study. Thirty (30) age and sex-matched, non-diabetic individuals were enrolled as negative controls. Their fasting blood sugar (FBS), HbA1c, and CD4 count were assayed using standardized procedures. The demographic and clinical data of the studied group and controls were compared with respect to age, sex, BMI, FBS, HbA1c, and CD4+ T cell counts. Result: The mean concentration of glucose (7.82 ± 2.58) and the percentage concentration of HBA1c (8.21 ± 2.31) were significantly higher in DM individuals as against the control (3.67 ± 0.66) (p = 0.0001) and (5.20 ± 0.48) (p = 0.0001) respectively. The CD4+ cell count was also significantly lower in DM subjects (843.58 ± 297.6) when compared with the control (1067.9 ±195.4) (p = 0.035). Conclusion: A significant reduction in CD4+ T cell level was noted among diabetic patients in our study, which could be a contributing factor for aggravating some of the associated complications in DM, especially those that involve susceptibility to infectious diseases. We found out that having Hb-AA is associated with normal or elevated CD4+ T cells in DM patients; whereas having the Hb-AS variant increases the chance of a low CD4+ T cell count. Assessment of CD4+ T cell count should be included as part of periodic investigations in DM patients, especially for those with unresolved complications, in spite of treatment.
{"title":"Low CD4+ T Cell count among HIV-seronegative Type 2 Diabetes Mellitus patients in Ilorin metropolis","authors":"Ilesanmi Ayodele O, Atanda Tiamiyu A, Ilesanmi Rose, Ogunniyi Tolulope J, Akinleye Waheed A","doi":"10.17352/2455-8583.000064","DOIUrl":"https://doi.org/10.17352/2455-8583.000064","url":null,"abstract":"Background and aims: Diabetes Mellitus (DM) is a metabolic disorder that manifests as chronic hyperglycemia accompanied by a dysfunctional metabolism of carbohydrates, lipids, and proteins. Several studies have earlier pointed out several complications associated with the disease and in particular, the sufferer’s susceptibility to various infectious diseases. We therefore sought to investigate the adaptive immune status of the condition, as represented by the assessment of CD4+ T cell count among DM patients. Method: Seventy-six type 2 DM patients were recruited for the study. Thirty (30) age and sex-matched, non-diabetic individuals were enrolled as negative controls. Their fasting blood sugar (FBS), HbA1c, and CD4 count were assayed using standardized procedures. The demographic and clinical data of the studied group and controls were compared with respect to age, sex, BMI, FBS, HbA1c, and CD4+ T cell counts. Result: The mean concentration of glucose (7.82 ± 2.58) and the percentage concentration of HBA1c (8.21 ± 2.31) were significantly higher in DM individuals as against the control (3.67 ± 0.66) (p = 0.0001) and (5.20 ± 0.48) (p = 0.0001) respectively. The CD4+ cell count was also significantly lower in DM subjects (843.58 ± 297.6) when compared with the control (1067.9 ±195.4) (p = 0.035). Conclusion: A significant reduction in CD4+ T cell level was noted among diabetic patients in our study, which could be a contributing factor for aggravating some of the associated complications in DM, especially those that involve susceptibility to infectious diseases. We found out that having Hb-AA is associated with normal or elevated CD4+ T cells in DM patients; whereas having the Hb-AS variant increases the chance of a low CD4+ T cell count. Assessment of CD4+ T cell count should be included as part of periodic investigations in DM patients, especially for those with unresolved complications, in spite of treatment.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.17352/2455-8583.000063
AA Haji Mona Hussain
Diabetes, a chronic metabolic disorder affecting millions worldwide, relies heavily on a stable and efficient supply chain for insulin, a life-saving hormone. However, the insulin supply chain faces multifaceted challenges that can disrupt access to this essential medication. In the realm of diabetes management, a novel and devastating occurrence has emerged—a severe shortage of insulin. This case report revolves around a singular clinical encounter that showcases a series of remarkable and uncommon aspects, which can enrich the knowledge of healthcare professionals. The patient’s condition presented several unique features, providing a learning opportunity that transcends the typical clinical scenarios seen in diabetes management. The findings surrounding the unavailability of insulin, the dire consequences it has on patients, and the clinical course and prognosis of an individual patient closely related to previous challenges. The shortage of insulin, though not a new challenge, has now reached unparalleled levels, resulting in life-threatening situations for those dependent on this vital hormone. This case report delves into a unique scenario where an individual patient’s health dramatically deteriorated due to the insulin scarcity, highlighting the urgency for comprehensive solutions and international cooperation to ensure access to this life-saving medication. This case report manuscript reviews the importance of enhancing the resistance and resilience of the insulin supply chain to ensure uninterrupted access to insulin for people with diabetes. We discuss the current challenges, their impact on diabetes management, and propose strategies to mitigate these issues. Strengthening the insulin supply chain is essential for the well-being of those living with diabetes, highlighting its significance for healthcare systems globally.
{"title":"Enhancing insulin supply chain resilience: A critical importance for diabetes management","authors":"AA Haji Mona Hussain","doi":"10.17352/2455-8583.000063","DOIUrl":"https://doi.org/10.17352/2455-8583.000063","url":null,"abstract":"Diabetes, a chronic metabolic disorder affecting millions worldwide, relies heavily on a stable and efficient supply chain for insulin, a life-saving hormone. However, the insulin supply chain faces multifaceted challenges that can disrupt access to this essential medication. In the realm of diabetes management, a novel and devastating occurrence has emerged—a severe shortage of insulin. This case report revolves around a singular clinical encounter that showcases a series of remarkable and uncommon aspects, which can enrich the knowledge of healthcare professionals. The patient’s condition presented several unique features, providing a learning opportunity that transcends the typical clinical scenarios seen in diabetes management. The findings surrounding the unavailability of insulin, the dire consequences it has on patients, and the clinical course and prognosis of an individual patient closely related to previous challenges. The shortage of insulin, though not a new challenge, has now reached unparalleled levels, resulting in life-threatening situations for those dependent on this vital hormone. This case report delves into a unique scenario where an individual patient’s health dramatically deteriorated due to the insulin scarcity, highlighting the urgency for comprehensive solutions and international cooperation to ensure access to this life-saving medication. This case report manuscript reviews the importance of enhancing the resistance and resilience of the insulin supply chain to ensure uninterrupted access to insulin for people with diabetes. We discuss the current challenges, their impact on diabetes management, and propose strategies to mitigate these issues. Strengthening the insulin supply chain is essential for the well-being of those living with diabetes, highlighting its significance for healthcare systems globally.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135218120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.17352/2455-8583.000062
Correia Cláudia, Cascais Inês, G. Rita, Mansilha Helena Ferreira, Morais Lurdes, Rios Marta, Afonso Alberto Caldas
Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction and Autonomic Dysregulation is a rare and complex pediatric syndrome with unknown etiology. The disease hallmark is sudden and severe obesity in early childhood, with a later onset of central hypoventilation, responsible for high mortality. We present the case of a 2.5-year-old boy with sudden weight gain starting after 12 months of age (18 kg in a year) and hypoventilation in the setting of acute nasopharyngitis, requiring Non-Invasive Ventilation (NIV) initiation. Additionally, he presented symptoms and signs of autonomic disturbance, neurodevelopmental delay and behavior disorders. High prolactin, leptin and insulin were also present. Despite periodic adjustment of settings and adherence to NIV and great efforts to control food intake, he remained morbidly obese and died during an infectious intercurrence at 6 years of age. This case illustrates the challenging diagnosis and treatment/management of this rare syndrome, which can have a variable and not always complete presentation and has no specific diagnostic test available. Identifying hypoventilation and NIV treatment is essential to decrease morbimortality. However, most patients do not live past ten years old.
{"title":"A rare and challenging case of ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) syndrome","authors":"Correia Cláudia, Cascais Inês, G. Rita, Mansilha Helena Ferreira, Morais Lurdes, Rios Marta, Afonso Alberto Caldas","doi":"10.17352/2455-8583.000062","DOIUrl":"https://doi.org/10.17352/2455-8583.000062","url":null,"abstract":"Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction and Autonomic Dysregulation is a rare and complex pediatric syndrome with unknown etiology. The disease hallmark is sudden and severe obesity in early childhood, with a later onset of central hypoventilation, responsible for high mortality. We present the case of a 2.5-year-old boy with sudden weight gain starting after 12 months of age (18 kg in a year) and hypoventilation in the setting of acute nasopharyngitis, requiring Non-Invasive Ventilation (NIV) initiation. Additionally, he presented symptoms and signs of autonomic disturbance, neurodevelopmental delay and behavior disorders. High prolactin, leptin and insulin were also present. Despite periodic adjustment of settings and adherence to NIV and great efforts to control food intake, he remained morbidly obese and died during an infectious intercurrence at 6 years of age. This case illustrates the challenging diagnosis and treatment/management of this rare syndrome, which can have a variable and not always complete presentation and has no specific diagnostic test available. Identifying hypoventilation and NIV treatment is essential to decrease morbimortality. However, most patients do not live past ten years old.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90606054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-21DOI: 10.17352/2455-8583.000061
Da-Ming Liao, Chen Chieh
The human body cannot produce omega-3 fatty acids and must obtain them from the diet. There are three types of omega-3 fatty acids that are needed by the human body, namely α-linolenic acid (ALA), Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA). Although studies have shown that omega-3 fatty acids cannot prevent or treat diabetes or heart diseases, they did improve the condition of insulin resistance and the level of triglycerides in the body. It is well known that being overweight leads to insulin resistance, which in turn leads to metabolic syndrome. Many animal experiments have already confirmed that long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) are beneficial in promoting insulin sensitivity. It inhibits nuclear transcription factor kappa B (NFκB), which is a key transcription factor for gene expression of inflammatory cytokines. On the other hand, studies have also pointed out that omega-3 polyunsaturated fatty acids do not improve the function of the kidney’s endothelial cells and high blood pressure in patients with type 2 diabetes.
{"title":"Benefits of omega-3 polyunsaturated fatty acids to patients with oral and metabolic diseases","authors":"Da-Ming Liao, Chen Chieh","doi":"10.17352/2455-8583.000061","DOIUrl":"https://doi.org/10.17352/2455-8583.000061","url":null,"abstract":"The human body cannot produce omega-3 fatty acids and must obtain them from the diet. There are three types of omega-3 fatty acids that are needed by the human body, namely α-linolenic acid (ALA), Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA). Although studies have shown that omega-3 fatty acids cannot prevent or treat diabetes or heart diseases, they did improve the condition of insulin resistance and the level of triglycerides in the body. It is well known that being overweight leads to insulin resistance, which in turn leads to metabolic syndrome. Many animal experiments have already confirmed that long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) are beneficial in promoting insulin sensitivity. It inhibits nuclear transcription factor kappa B (NFκB), which is a key transcription factor for gene expression of inflammatory cytokines. On the other hand, studies have also pointed out that omega-3 polyunsaturated fatty acids do not improve the function of the kidney’s endothelial cells and high blood pressure in patients with type 2 diabetes.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89513384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.17352/2455-8583.000060
Proskurina Мargarita V, Taranushenko Tatiana E, Kiseleva Natalia G
Type 1 diabetes mellitus (T1DM) in children and adolescents remains one of the urgent problems of pediatric endocrinology. There is a constant increase in disease rates, both worldwide and Russia. The occurrence of pathology in childhood leads to a decrease in the quality of life of patients and their parents, the early development of chronic complications and disability, which makes type 1 diabetes a social problem in society. Despite numerous scientific works devoted to the study of the factors of manifestation of the disease, the causes of the occurrence are still unclear and ambiguous. The purpose of the study: is to identify and study possible clinical and laboratory features of the onset of type 1 diabetes in children and adolescents permanently residing in the territory of closed administrative-territorial entities (ZATO). Materials and methods: a continuous cohort retrospective study of children with type 1 DM was conducted for the period from 2009-2019, permanently residing in the ZATO territory to obtain data related to the period of manifestation of the disease. The study group included 55 children from 0 - 18 years of age suffering from type 1 diabetes. Results: Data on the anamnesis of life and disease, and indicators of clinical and laboratory studies (fasting glycemia, postprandial glycemia, average daily glycemia, average amplitude of glycemia fluctuations and glycated hemoglobin) at the time of disease manifestation are presented. A comparative analysis was carried out with the indicators of the Krasnoyarsk Territory, Russia, the obtained features were described.
{"title":"The period of manifestation of type 1 diabetes mellitus in children and adolescents living on the territory of ZATO (Closed administrative-territorial entity)","authors":"Proskurina Мargarita V, Taranushenko Tatiana E, Kiseleva Natalia G","doi":"10.17352/2455-8583.000060","DOIUrl":"https://doi.org/10.17352/2455-8583.000060","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) in children and adolescents remains one of the urgent problems of pediatric endocrinology. There is a constant increase in disease rates, both worldwide and Russia. The occurrence of pathology in childhood leads to a decrease in the quality of life of patients and their parents, the early development of chronic complications and disability, which makes type 1 diabetes a social problem in society. Despite numerous scientific works devoted to the study of the factors of manifestation of the disease, the causes of the occurrence are still unclear and ambiguous. The purpose of the study: is to identify and study possible clinical and laboratory features of the onset of type 1 diabetes in children and adolescents permanently residing in the territory of closed administrative-territorial entities (ZATO). Materials and methods: a continuous cohort retrospective study of children with type 1 DM was conducted for the period from 2009-2019, permanently residing in the ZATO territory to obtain data related to the period of manifestation of the disease. The study group included 55 children from 0 - 18 years of age suffering from type 1 diabetes. Results: Data on the anamnesis of life and disease, and indicators of clinical and laboratory studies (fasting glycemia, postprandial glycemia, average daily glycemia, average amplitude of glycemia fluctuations and glycated hemoglobin) at the time of disease manifestation are presented. A comparative analysis was carried out with the indicators of the Krasnoyarsk Territory, Russia, the obtained features were described.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86065458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-13DOI: 10.17352/2455-8583.000059
Z. Stephanie, Paracha Nawar, Rafii Daniel
Primary aldosteronism, also known as Conn’s Syndrome, is one of the most common causes of secondary hypertension. It is a disorder of the adrenal glands that is caused by the hypersecretion of the hormone aldosterone from the adrenal glands.
{"title":"A case of primary aldosteronism","authors":"Z. Stephanie, Paracha Nawar, Rafii Daniel","doi":"10.17352/2455-8583.000059","DOIUrl":"https://doi.org/10.17352/2455-8583.000059","url":null,"abstract":"Primary aldosteronism, also known as Conn’s Syndrome, is one of the most common causes of secondary hypertension. It is a disorder of the adrenal glands that is caused by the hypersecretion of the hormone aldosterone from the adrenal glands.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78260696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Obesity and Type 2 Diabetes (T2D) are crucial problems worldwide. Oral semaglutide (Rybelsus) was introduced to medical practice for Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA). Case presentation: The patient is 24-year-old female with obesity (BMI 39.3 kg/m2), T2D and fatty liver. Results: She started and increased Rybelsus from 3mg, 7mg to 14mg/day each 4 weeks. She showed significant efficacy for 4 months as HbA1c 6.3% to 5.6% and weight 107kg to 103kg, without Gastrointestinal Adverse Events (GIAEs). Discussion: Rybelsus is provided just after waking up, and kept >30 min fasting period. Longer fasting time may contribute current effect.
{"title":"Clinically Both Effects of Weight and Glucose Variability by Oral Semaglutide (Rybelsus) for Younger Female Patient with Type 2 Diabetes (T2D)","authors":"B. Hiroshi, Yamashita Hisako, Kato Yoshinobu, Ogura Katsunori, Kato Yoshikane, Kanazawa Setsuko","doi":"10.33805/2638-812x.126","DOIUrl":"https://doi.org/10.33805/2638-812x.126","url":null,"abstract":"Background: Obesity and Type 2 Diabetes (T2D) are crucial problems worldwide. Oral semaglutide (Rybelsus) was introduced to medical practice for Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA). Case presentation: The patient is 24-year-old female with obesity (BMI 39.3 kg/m2), T2D and fatty liver. Results: She started and increased Rybelsus from 3mg, 7mg to 14mg/day each 4 weeks. She showed significant efficacy for 4 months as HbA1c 6.3% to 5.6% and weight 107kg to 103kg, without Gastrointestinal Adverse Events (GIAEs). Discussion: Rybelsus is provided just after waking up, and kept >30 min fasting period. Longer fasting time may contribute current effect.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78768355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manal Hamed Awad Elmadih, A. Khalid, Ibrahim Abdelrhim Ali, Adam Hussein, Omer Abd elaziz Musa
The study discussed the physiological changes of pregnancy in Sudanese pregnant women the study aimed to assess the effect of pregnancy in Red blood cell, Packed Cell Volume (PCV) and hemoglobin among Sudanese pregnant women, and to correlate the PCV as an indicator of hemodilution in different trimesters among Sudanese women using or not using iron and folic acid supplement. The researcher used across sectional study which applied on 300 pregnant women presented to Port-Sudan obstetrical Hospital for antenatal care from 2019 to 2020. The samples were collected with Chemically clean and sterile disposable needles, syringes and swab were used for all blood samples, 4.5 mL of blood was collected from each participant into a tube containing the anticoagulant Ethylene Diamine Tetraacetic Acid (EDTA), gently mixed the tube five to six times A full blood count was performed using Hematological analyzer (Sysmex XP 300). The study found out that 90 women in each trimester of pregnancy (first, second and third) the mean value of Hemoglobin (Hb) in pregnant women was 11.3±1.4 g/dl, 11.4 ±1.4 g/dl and 10.3±1.2 g/dl in 1st, 2nd and 3rd trimester respectively. The study also found out that the mean value of PCV was 33.35%. Moreover, Hb was lower during 3rd trimester compared with 1st (hemodilution). The cut off level for anemia in Sudanese non pregnant females could be even lower than 11g/dl as the normal level was found to be lower than the international one. Due to hemodilution anemia in pregnancy is considered if Hb less than 9g/dl. The study recommends that diagnosis of anemia should be revised during pregnancy as this study has shown Hb level less than 9g/dl (66%) can be the cut off level.
本研究探讨了苏丹孕妇妊娠的生理变化，旨在评估妊娠对苏丹孕妇红细胞、堆积细胞体积(PCV)和血红蛋白的影响，并将PCV作为苏丹妇女在使用或不使用铁和叶酸补充剂的不同孕期血液稀释的指标进行关联。研究人员采用了横断面研究，该研究适用于2019年至2020年在苏丹港产科医院接受产前护理的300名孕妇。使用化学清洁和无菌的一次性针头采集样本，所有血液样本均使用注射器和拭子，每位参与者取4.5 mL血液放入含有抗凝剂乙二胺四乙酸(EDTA)的试管中，轻轻混合5至6次，使用血液分析仪(Sysmex XP 300)进行全血计数。研究发现，90名孕妇在妊娠第一、第二、第三三个孕期的血红蛋白(Hb)均值分别为11.3±1.4 g/dl、11.4±1.4 g/dl和10.3±1.2 g/dl。研究还发现PCV的平均值为33.35%。此外，与妊娠早期(血液稀释)相比，妊娠晚期Hb较低。苏丹未怀孕女性贫血的临界值甚至可以低于11g/dl，因为发现正常水平低于国际标准。如果Hb低于9g/dl，则考虑妊娠期血液稀释性贫血。该研究建议在怀孕期间修改贫血的诊断，因为该研究表明Hb水平低于9g/dl(66%)可以作为临界值。
{"title":"Hemoglobin and Red Blood Cells Count in Pregnant Sudanese Women","authors":"Manal Hamed Awad Elmadih, A. Khalid, Ibrahim Abdelrhim Ali, Adam Hussein, Omer Abd elaziz Musa","doi":"10.33805/2638-812x.125","DOIUrl":"https://doi.org/10.33805/2638-812x.125","url":null,"abstract":"The study discussed the physiological changes of pregnancy in Sudanese pregnant women the study aimed to assess the effect of pregnancy in Red blood cell, Packed Cell Volume (PCV) and hemoglobin among Sudanese pregnant women, and to correlate the PCV as an indicator of hemodilution in different trimesters among Sudanese women using or not using iron and folic acid supplement. The researcher used across sectional study which applied on 300 pregnant women presented to Port-Sudan obstetrical Hospital for antenatal care from 2019 to 2020. The samples were collected with Chemically clean and sterile disposable needles, syringes and swab were used for all blood samples, 4.5 mL of blood was collected from each participant into a tube containing the anticoagulant Ethylene Diamine Tetraacetic Acid (EDTA), gently mixed the tube five to six times A full blood count was performed using Hematological analyzer (Sysmex XP 300). The study found out that 90 women in each trimester of pregnancy (first, second and third) the mean value of Hemoglobin (Hb) in pregnant women was 11.3±1.4 g/dl, 11.4 ±1.4 g/dl and 10.3±1.2 g/dl in 1st, 2nd and 3rd trimester respectively. The study also found out that the mean value of PCV was 33.35%. Moreover, Hb was lower during 3rd trimester compared with 1st (hemodilution). The cut off level for anemia in Sudanese non pregnant females could be even lower than 11g/dl as the normal level was found to be lower than the international one. Due to hemodilution anemia in pregnancy is considered if Hb less than 9g/dl. The study recommends that diagnosis of anemia should be revised during pregnancy as this study has shown Hb level less than 9g/dl (66%) can be the cut off level.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83746465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.17352/2455-8583.000058
C. Pekin, M. Mchale, G. Byrne
Introduction: Bariatric surgical candidates confer an elevated risk of psychopathology. Prior reviews highlight the vulnerability and bidirectionality of psychopathology in people with Type 2 Diabetes Mellitus (T2DM). Despite this, current evidence for the rates of psychopathology in people with T2DM pre and post-bariatric surgery has yet to be systematically reviewed. Objective: To perform a systematic review of the prevalence of psychopathology in adults with Type 2 Diabetes Mellitus pre and post-bariatric surgery. Results: Seven studies fulfilled the inclusion criteria, from 45,576 studies on the digital search of databases. Conclusions: Scant evidence exists which specifies cohorts of bariatric surgical patients with T2DM and rates of psychopathology. Further research is warranted to understand the risks, measures, and potential interventions for this subgroup.
{"title":"Prevalence of Psychopathology in Bariatric Surgical Candidates with Type 2 Diabetes Mellitus: Systematic Review","authors":"C. Pekin, M. Mchale, G. Byrne","doi":"10.17352/2455-8583.000058","DOIUrl":"https://doi.org/10.17352/2455-8583.000058","url":null,"abstract":"Introduction: Bariatric surgical candidates confer an elevated risk of psychopathology. Prior reviews highlight the vulnerability and bidirectionality of psychopathology in people with Type 2 Diabetes Mellitus (T2DM). Despite this, current evidence for the rates of psychopathology in people with T2DM pre and post-bariatric surgery has yet to be systematically reviewed. Objective: To perform a systematic review of the prevalence of psychopathology in adults with Type 2 Diabetes Mellitus pre and post-bariatric surgery. Results: Seven studies fulfilled the inclusion criteria, from 45,576 studies on the digital search of databases. Conclusions: Scant evidence exists which specifies cohorts of bariatric surgical patients with T2DM and rates of psychopathology. Further research is warranted to understand the risks, measures, and potential interventions for this subgroup.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86561443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diminished Ovarian Reserve (DOR) is one of the main causes of female infertility and is common in women under of 40s. The definition and diagnosis are pragmatic and the treatment in mainstream medicine is not promising as many of the sufferers have to choose IVF as the last resort. DOR could be the reduced ability of producing quality egg or the poor quality of eggs produced. Premature Ovarian Insufficiency (POI) belongs to its aggravate stage. Traditional Chinese medicine has long been employed in treating female infertility, and a large proportion of the cases in the records now could be classified as DOR or POI. Some clinical reports have demonstrated great potential in treating DOR & POI. The authors have treated many cases of DOR and POI, and great achievements have been recorded. The protocol used in the treatment is a whole system approach which combines acupuncture, Chinese herbal medicine and lifestyle advice into an organic composition to maximize the effects. The cases reported here are of good details and could demonstrate the application of the TCM diagnosis of syndrome pattern which logically leads to the whole-system treatment implementation.
{"title":"Cases Study on the Management of Diminished Ovarian Reserve (DOR) and Premature Ovarian Insufficiency (POI) with Traditional Chinese Medicine (TCM)","authors":"D. Jiang, F. Meng","doi":"10.33805/2638-812x.124","DOIUrl":"https://doi.org/10.33805/2638-812x.124","url":null,"abstract":"Diminished Ovarian Reserve (DOR) is one of the main causes of female infertility and is common in women under of 40s. The definition and diagnosis are pragmatic and the treatment in mainstream medicine is not promising as many of the sufferers have to choose IVF as the last resort. DOR could be the reduced ability of producing quality egg or the poor quality of eggs produced. Premature Ovarian Insufficiency (POI) belongs to its aggravate stage. Traditional Chinese medicine has long been employed in treating female infertility, and a large proportion of the cases in the records now could be classified as DOR or POI. Some clinical reports have demonstrated great potential in treating DOR & POI. The authors have treated many cases of DOR and POI, and great achievements have been recorded. The protocol used in the treatment is a whole system approach which combines acupuncture, Chinese herbal medicine and lifestyle advice into an organic composition to maximize the effects. The cases reported here are of good details and could demonstrate the application of the TCM diagnosis of syndrome pattern which logically leads to the whole-system treatment implementation.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83401790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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