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Persistence of MRSA and ESBL-producing E. coli and K. oxytoca in river water 耐甲氧西林金黄色葡萄球菌和产esbl的大肠杆菌和脱氧梭菌在河水中的持久性
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100072
Sarah M. Essert , Nicole Zacharias , Tabea Precht , Debbie Pankratz , Karolin Funken , Nico T. Mutters , Thomas Kistemann , Christiane Schreiber

Due to climate change precipitation patterns are changing in terms of frequency and quantity in Germany. As a result, prolonged dry weather can lead to extremely low flow rates in river systems with large portions of treated wastewater. However, storm events and heavy rainfall events are increasing too, which may lead to higher frequencies of combined sewer overflows. Increased microbial pollution (e.g. coliform bacteria, clostridia, faecal streptococci) of waterbodies after heavy precipitation events was demonstrated in several studies. Pathogenic multi-resistant bacteria enter waterbodies via sewer systems. The persistence potential of such pathogens in aquatic environments is mainly still unknown. This study investigated the growth behaviour of Gram-negative extended spectrum beta-Lactamase-producing Klebsiella oxytoca and Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus in river water. The concentrations of these antibiotic-resistant bacteria were monitored in batch experiments using river water differently impacted by wastewater. Staphylococcus aureus persisted for at least 3 days at incubation temperatures of 8 and 18 °C. The persistence of Koxytoca and Ecoli was shown for at least 37 days at both temperatures. In the river water at 8 °C, bacteria concentrations decreased slower, suggesting diminished persistence of ARB (antibiotic-resistant bacteria) with increasing temperatures. Initial concentrations of ARB and other pathogens in river water corresponded to the impact of wastewater. However, significant effects on the persistence itself by wastewater impact could not be shown for the bacteria species tested. Further studies should pursue our approaches concerning the persistence of pathogenic ARB in freshwater to assess the health risk for humans and animals.

由于气候变化,降水模式在德国的频率和数量方面正在发生变化。因此,长时间的干燥天气可能导致河流系统的流量极低,其中含有大量处理过的废水。然而,暴雨事件和强降雨事件也在增加,这可能导致合流下水道溢流的频率更高。几项研究表明,强降水事件后水体的微生物污染(如大肠菌群、梭状芽孢杆菌、粪便链球菌)增加。致病性多重耐药细菌通过下水道系统进入水体。这些病原体在水生环境中的持久性潜力主要仍然未知。本研究研究了革兰氏阴性产广谱β -内酰胺酶克雷伯菌和大肠杆菌以及革兰氏阳性耐甲氧西林金黄色葡萄球菌在河水中的生长行为。利用受不同污水影响程度的河水进行了批量试验,监测了这些耐药菌的浓度。金黄色葡萄球菌在8°C和18°C的孵育温度下可存活至少3天。结果表明,在这两种温度下,后芽胞杆菌和大肠杆菌的持久性至少为37天。在8°C的河水中,细菌浓度下降较慢,表明ARB(抗生素耐药细菌)的持久性随着温度的升高而降低。河水中ARB和其他病原体的初始浓度与废水的影响相对应。然而,污水影响对所测细菌种类的持久性本身没有显着影响。进一步的研究应遵循我们关于淡水中致病性ARB持续存在的方法,以评估对人类和动物的健康风险。
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引用次数: 0
Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data 基于流行病学数据的中国全氟辛烷磺酸和全氟辛酸暴露健康风险评估
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100066
Yun-Ting Zhang , Huihui Bao , Lei Zhang , Sheng Wen , Weihong Tan , Mohammed Zeeshan , Ming-Kun Sun , Chu Chu , Zhao-Huan Gui , Li-Zi Lin , Ru-Qing Liu , Xiao-Wen Zeng , Yunjiang Yu , Guang-Hui Dong

Background

Health risk assessment based on epidemiological data for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are evidenced. Whereas information about health-based guidance values (HBGVs) and health risk for Chinese population related to PFOS and PFOA is scarce.

Objectives

To provide candidate HBGVs for PFOS and PFOA based on Chinese epidemiological data and assess the health risk related to excessive exposure.

Methods

We reviewed scientific literature and collected available original data from epidemiological studies conducted in China. Critical endpoints and data were selected and used in benchmark dose (BMD) analysis to obtain lower confidence limits of BMD (BMDLs) of PFOS and PFOA. Physiologically based pharmacokinetic (PBPK) models were applied to calculate the point of departure (PODs) for PFOS and PFOA, which led to the determination of the HBGVs for the said chemicals. Margin of exposure (MOE) method was used to evaluate the health risk of population based on exposure data among Chinese and HBGVs.

Results

Alanine aminotransferase (ALT), total cholesterol (TC) and birth weight (BW) were selected as critical endpoints. Epidemiological data from 4,224 adults, 2,153 paired mother-newborn, 2,518 newborns, 439 pregnant women and 733 children in China were included in this study. BMDLs and PODs for PFOS are varied while BMDLs for PFOA were similar. PODs for PFOS (1.56 ng/kg/day) and PFOA (1.52 ng/kg/day) based on BW using National Birth Cohort Study were selected as HBGVs. Most MOEs for PFOS and PFOA among Chinese population were larger than 1 and smaller than 100, indicating moderate concern. Around 16% MOEs for PFOS were smaller than 1, implying high concern.

Conclusion

The HBGVs for PFOS and PFOA were 1.56 ng/kg/day and 1.52 ng/kg/day, respectively. Health risk of Chinese population related to PFOS and PFOA exposure should be concerned and more studies should be conducted to evaluate the risk of the chemicals.

背景:基于流行病学数据对全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)进行了健康风险评估。而与全氟辛烷磺酸和全氟辛烷磺酸相关的中国人群健康指导值(hbgv)和健康风险信息却很少。目的根据中国流行病学资料提供PFOS和PFOA的候选hbgv,并评估过量暴露的健康风险。方法回顾科学文献,收集在中国开展的流行病学研究的现有原始资料。选择关键终点和数据用于基准剂量(BMD)分析,以获得全氟辛烷磺酸和全氟辛烷磺酸的BMD (BMDLs)的下限置信限。应用基于生理的药代动力学(PBPK)模型计算全氟辛烷磺酸和全氟辛烷磺酸的起始点(pod),从而确定上述化学物质的hbgv。基于中国人与乙肝病毒携带者的暴露数据,采用暴露边际(MOE)法评价人群的健康风险。结果选择丙氨酸转氨酶(ALT)、总胆固醇(TC)和出生体重(BW)作为关键终点。本研究纳入了中国4,224名成年人、2,153对母婴、2,518名新生儿、439名孕妇和733名儿童的流行病学数据。全氟辛烷磺酸的bmdl和pod不同,而全氟辛烷磺酸的bmdl相似。根据国家出生队列研究,选择全氟辛烷磺酸(1.56 ng/kg/day)和全氟辛烷磺酸(1.52 ng/kg/day)作为hbgv。中国人群对PFOS和PFOA的MOEs大多大于1,小于100,属于中度关注。约16%的全氟辛烷磺酸MOEs小于1,表明高度关注。结论PFOS和PFOA的hbgv分别为1.56 ng/kg/day和1.52 ng/kg/day。全氟辛烷磺酸和全氟辛烷磺酸暴露对中国人群的健康风险值得关注,并应开展更多的研究来评估这些化学品的风险。
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引用次数: 0
Dengue outbreak following unprecedented flooding in Pakistan 巴基斯坦发生史无前例的洪水后爆发登革热
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100076
Omer A. Shaikh , Mirza T. Baig , Sara Tahir , Ad-Duhaa E. Parekh , Abdulqadir J. Nashwan

An unexpected rise in dengue cases has overwhelmed hospitals in Pakistan. Floods and intense monsoon rain have affected almost 33 million people since June 2022. Heavy monsoon rains may be a result of rising water temperatures. Dengue poses a severe risk to public health globally and to countries affected by floods, particularly Pakistan and the whole Indian subcontinent. Pakistan's expanding urban and agricultural economies place it at a higher risk for contracting vector-borne diseases.

登革热病例的意外增加使巴基斯坦的医院不堪重负。自2022年6月以来,洪水和强季风性降雨影响了近3300万人。季风性暴雨可能是水温上升的结果。登革热对全球和受洪水影响的国家,特别是巴基斯坦和整个印度次大陆的公共卫生构成严重威胁。巴基斯坦不断扩大的城市和农业经济使其感染媒介传播疾病的风险更高。
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引用次数: 0
Access to water sources and intimate partner violence against women in 26 Sub-Saharan African countries 撒哈拉以南非洲26个国家获得水源和亲密伴侣对妇女的暴力行为
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100063
Jovine Bachwenkizi , Hussein Mohamed , Priscilla Funsan , Dennis Rweyemamu , William Nelson , Magdalena Shao , Heribert Kaijage , Namakau Muyumbana , Said Salehe , Luco P. Mwelange , Saumu Shabani , Baldwina T. Olirk , Simon Mamuya , Jane Mlimbila

Background

Intimate partner violence (IPV) against women is a serious problem in many developing countries. Longer distance traveled to access water services may affect women's ability to meet domestic obligations and results in violence. However, the associations between times spent by women to access water services and intimate partner violence against women in Sub-Saharan Africa (SSA) remain unknown.

Methods

We used population-based data collected from demographic and health surveys (DHS) in 26 SSA, to examine the associations between round-trip time to water sources and IPV. We estimated round-trip time to water sources based on the self-reported experience of women through their time spent collecting water during the period of 2008 and 2020 as presented in the DHS surveys. Primary outcomes were all self-reported and were derived from the DHS questionnaires about IPV, especially physical violence. We categorized IPV into two groups (Severe and less severe IPV). Respondents who reported being kicked, strangled, threatened with a knife/gun or other weapons by their husbands, or hurt were pooled together and labelled as having experienced severe IPV. Those who claimed to have been pushed, had their arms twisted, or had their hair pulled were grouped and classified as less severe forms of violence. Multivariable logistic regression was performed by fitting crude models and adjusted models. We also conducted a sensitivity analysis, stratification, and country-specific analysis to examine the contributions of these factors to the associations between round-trip time to water sources and IPV. The estimated results are presented as an odds ratio (OR) and their 95% confidence interval (CI).

Results

A total of 14,714 (11.2%) women faced severe IPV and 38,222 (28.9%) faced less severe IPV. Results showed that a 30 min increase in round-trip fetching time was associated with an increase in severe IPV and the crude OR was 1.06 (95% CI: 1.05, 1.07) for all 26 countries. After adjusting for covariates, the association of round-trip time to water sources and severe IPV remained positive and significant with an OR of 1.03 (95% CI: 1.01, 1.05). Furthermore, there were positive and significant associations between round-trip time and less severe IPV before and after adjusting for covariates. There were positive associations between round-trip time to basic access to water sources and severe IPV with an OR of 1.08 (95% CI: 1.05, 1.10). For potential effect modifiers, our results revealed disparities in IPV estimates stratified by husbands who consumed alcohol, level of education of husbands, and age of respective women. There were differences in the estimates between countries, the largest increment in severe IPV was observed in Comoros, Sierra Leone, and Namibia.

Conclusions

This cross-sectional study provides persuasive evidence for the association between round-trip tim

在许多发展中国家,针对妇女的最终伴侣暴力(IPV)是一个严重的问题。前往取水服务的路程较长,可能影响妇女履行家庭义务的能力,并导致暴力。然而,在撒哈拉以南非洲(SSA),妇女获得供水服务所花费的时间与亲密伴侣对妇女的暴力行为之间的关系尚不清楚。方法使用26个SSA的人口与健康调查(DHS)收集的基于人群的数据,研究到水源的往返时间与IPV之间的关系。我们根据2008年至2020年期间妇女自述的取水经验,根据国土安全部的调查,估计了到水源的往返时间。主要结果均为自我报告,并来自国土安全部关于IPV,特别是身体暴力的问卷。我们将IPV分为两组(重度IPV和轻度IPV)。报告被丈夫踢、勒死、用刀/枪或其他武器威胁或受伤的受访者被集中在一起,并被标记为经历过严重的IPV。那些声称被推过、扭过胳膊或扯过头发的人被归类为较轻的暴力形式。通过拟合粗模型和调整模型进行多变量logistic回归。我们还进行了敏感性分析、分层和国别分析,以检验这些因素对往返水源时间和IPV之间关系的贡献。估计结果以比值比(OR)及其95%置信区间(CI)表示。结果重度IPV 14714例(11.2%),轻度IPV 38222例(28.9%)。结果显示,往返取水时间增加30分钟与严重IPV的增加有关,所有26个国家的原始OR为1.06 (95% CI: 1.05, 1.07)。在调整协变量后,往返水源的时间与严重IPV的相关性仍然为正相关,OR为1.03 (95% CI: 1.01, 1.05)。此外,在调整协变量前后,往返时间与轻度IPV之间存在显著的正相关关系。到基本水源的往返时间与严重IPV之间存在正相关,OR为1.08 (95% CI: 1.05, 1.10)。对于潜在的影响调节因子,我们的结果揭示了按丈夫是否饮酒、丈夫的教育水平和各自女性的年龄分层的IPV估计的差异。各国之间的估计数存在差异,在科摩罗、塞拉利昂和纳米比亚观察到严重IPV的最大增幅。结论本横断面研究为往返水源时间与IPV之间的关系提供了有说服力的证据。我们的研究结果强调,有必要通过确保面临水不安全的社区获得适当的水服务来保护妇女免受IPV的侵害。
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引用次数: 0
Airborne soil and dust are potential sources of antimony to residents across Delhi: Exposure likely to occur via dermal route 空气中的土壤和灰尘是德里居民的潜在锑来源:可能通过皮肤途径暴露
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100075
Manoj P. Singh , Saroj Bhattacharyya , Khorshed Chinu , Rabeya Akter , Christopher E. Marjo

Background

There is an urgent need to assess sources of toxic metals in highly urbanized environments, to identify high risk areas for testing to enable planning to minimize exposure to residents. Notable toxic metals identified in this study were Antimony (Sb) and mercury (Hg), listed as priority pollutants by USEPA that can cause a variety of diseases in humans, and cobalt (Co), compounds of which have been shown to be carcinogenic in animal studies.

Objectives

Objectives of this study were to measure the level and spatial distribution of toxic metals in roadside soil and road dust across a large area of Delhi. Toxic metals with notably high levels were identified and assessed for potential environmental exposure, non-carcinogenic and carcinogenic risks to the population in the study area.

Research methods

A sampling scheme was designed to collect soil from a wide range of roadside environments across the urban region of Delhi. The soil and dust fractions were separated and selected toxic metals extracted and analyzed on Inductively Coupled Plasma – Mass Spectroscopy (ICP–MS) adopting USEPA methodology.

Results

Mean concentrations of Sb (2.62 and 3.59 in μgg−1) were 13 and 18 times higher than background level (0.2 μgg−1) in fine fractions of roadside soil and road dust, respectively in all areas sampled. The Hg and Co were moderately and minimally enriched in a fine fraction of soil and dust, respectively. The fine fraction of soil and dust showed a significant decrease in the Cu/Sb ratio compared to the coarse fraction suggesting an anthropogenic addition of Sb from vehicular brake pads. This study is the first of its type to calculate the cancer risk assessment of Sb from inhalation exposure.

Conclusion

Measurements of Sb, Hg and Co in roadside soil and dust are mapped to highlight regions where testing of the population would be advisable. In addition, toxic levels of Sb may enter the human body via a dermal route and cause various diseases including diabetes mellitus and gestational diabetes mellitus. Finally, our results suggest an immediate change to antimony free brake pads for all vehicles is recommended.

背景:迫切需要评估高度城市化环境中有毒金属的来源,以确定高风险地区进行检测,从而使规划能够最大限度地减少对居民的暴露。在这项研究中发现的值得注意的有毒金属是锑(Sb)和汞(Hg),它们被美国环保署列为可导致人类多种疾病的优先污染物,以及钴(Co),其化合物在动物研究中已被证明具有致癌性。本研究的目的是测量德里一大片地区路边土壤和道路尘埃中有毒金属的水平和空间分布。研究人员确定并评估了研究区域人口潜在的环境暴露、非致癌风险和致癌风险。研究方法设计了一个抽样方案,从德里市区的各种路边环境中收集土壤。采用USEPA方法对土壤和粉尘组分进行分离,选取有毒金属进行电感耦合等离子体质谱(ICP-MS)分析。结果各地区道路土壤和道路粉尘细组分中Sb的平均浓度(2.62 μgg−1)和Sb的平均浓度(3.59 μgg−1)分别是本底水平(0.2 μgg−1)的13倍和18倍。Hg和Co在土壤和粉尘中分别有中度和轻度富集。与粗粒组分相比,细粒组分土壤和粉尘的Cu/Sb比值显著降低,这表明汽车刹车片人为添加了Sb。本研究首次计算了吸入接触锑的致癌风险评估。结论路边土壤和粉尘中Sb、Hg和Co的测量值绘制了地图,以突出建议对人群进行检测的区域。此外,Sb的毒性水平可通过皮肤途径进入人体,引起各种疾病,包括糖尿病和妊娠糖尿病。最后,我们的研究结果建议立即更换所有车辆的无锑刹车片。
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引用次数: 0
Speech at the awarding ceremony of NST Sustainability Award 在NST可持续发展奖颁奖典礼上的致辞
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100064
Zhenhua Xie
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引用次数: 0
Lack of SARS-CoV-2 in environmental samples collected from September 2020-February 2021 in a university that followed CDC reopening guidance 在一所遵循疾病预防控制中心重新开放指导的大学中,从2020年9月至2021年2月收集的环境样本中缺乏SARS-CoV-2
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100061
Hongwan Li , Sripriya Nannu Shankar , Chiran T. Witanachchi , John A. Lednicky , Julia C. Loeb , Md. Mahbubul Alam , Z. Hugh Fan , Michael Lauzardo , Karim Mohamed , Arantzazu Eiguren-Fernandez , Chang-Yu Wu

This study aimed to provide environmental surveillance data for evaluating the risk of acquiring SARS-CoV-2 in public areas with high foot traffic in a university. Air and surface samples were collected at a university that had the second highest number of COVID-19 cases among public higher education institutions in the U.S. during Fall 2020. A total of 60 samples were collected in 16 sampling events performed during Fall 2020 and Spring 2021. Nearly 9800 students traversed the sites during the study period. SARS-CoV-2 was not detected in any air or surface samples. The university followed CDC guidance, including COVID-19 testing, case investigations, and contact tracing. Students, faculty, and staff were asked to maintain physical distancing and wear face coverings. Although COVID-19 cases were relatively high at the university, the possibility of acquiring SARS-CoV-2 infections at the sites tested was low.

本研究旨在为评价某高校高人流量公共区域感染SARS-CoV-2风险提供环境监测数据。2020年秋季,在美国公立高等教育机构中COVID-19病例数第二高的一所大学收集了空气和地表样本。在2020年秋季和2021年春季进行的16次抽样活动中共收集了60份样本。在研究期间,近9800名学生穿越了这些地点。在任何空气或表面样本中均未检测到SARS-CoV-2。该大学遵循了疾病预防控制中心的指导,包括COVID-19检测、病例调查和接触者追踪。学生、教职员工被要求保持身体距离,并戴上口罩。虽然该大学的COVID-19病例相对较高,但在检测地点感染SARS-CoV-2的可能性很低。
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引用次数: 0
Water quality in rural Greenland - acceptability and safety 格陵兰农村的水质——可接受性和安全性
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100065
Judith Y.A. Maréchal , Lisbeth Truelstrup Hansen , Pernille Erland Jensen

The low proportion of households with piped drinking water in Greenlandic settlements – and elsewhere in the Arctic, leads to improvised methods of household water storage and water saving practices that could present a risk for public health.

This interview-based study investigated the perceptions of safety and acceptability of the water supply in rural Greenlandic households. The bacterial quality of the water distributed by the public supply before and after storage in the homes, of alternative water sourced from nature by the users themselves, and of shared handwash basins used in un-piped homes, was analyzed.

The treated water distributed by the rural Greenlandic water supply was acceptable to most users, although half of them expressed concerns about its quality, and distrusted the state of the infrastructure delivering piped water. For drinking, most respondents preferred untreated water from nature, but a majority used mainly piped water for practical reasons of access. The microbial quality of the public water supply met legislative requirements in most cases, but was found to deteriorate during both distribution to some taps, and storage in the homes, which constitutes a challenge to the reliable provision of safe water to users. Water from alternative sources showed slightly higher heterotrophic plate counts (HPC) than piped water, but no Escherichia coli. As for washbasins, they were found to have high levels of contamination in all three bacterial parameters investigated (HPC, coliforms and E. coli), indicating a possible transmission route for pathogens.

In conclusion, while the quality of treated water was overall good at distribution, the water saving and storage practices developed to compensate for the lack of piping may threaten public health. Alternative water sources are culturally important and trusted by users, although the possible impact of changes in climate and land use on the reliability of their quality is unknown.

在格陵兰定居点和北极其他地方,有管道饮用水的家庭比例很低,导致家庭用水储存和节水做法的临时方法可能对公众健康构成威胁。这项基于访谈的研究调查了格陵兰农村家庭对供水的安全性和可接受性的看法。分析了公共供水分配的水在家庭储存前后的细菌质量,用户自己从自然中获取的替代水,以及在没有管道的家庭中使用的共用洗手盆。格陵兰农村供水分配的处理过的水对大多数用户来说是可以接受的,尽管其中一半人对水的质量表示关切,并且不信任输送管道水的基础设施的状况。在饮用水方面,大多数受访者更喜欢未经处理的自然水,但出于获取的实际原因,大多数人主要使用管道水。公共供水的微生物质量在大多数情况下符合立法要求,但发现在分配到一些水龙头和在家庭储存期间恶化,这对向用户可靠地提供安全用水构成挑战。从其他来源的水显示稍高的异养板计数(HPC)比自来水,但没有大肠杆菌。至于洗手盆,它们被发现在调查的所有三种细菌参数(HPC、大肠菌群和大肠杆菌)中都有高度污染,表明病原体可能存在传播途径。最后,虽然处理过的水在分配方面总体质量良好,但为弥补管道不足而开发的节水和储存做法可能威胁到公众健康。替代水源在文化上是重要的,并受到用户的信任,尽管气候和土地利用变化对其质量可靠性的可能影响尚不清楚。
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引用次数: 1
Long-term air pollution exposures on type 2 diabetes prevalence and medication use 长期空气污染暴露对2型糖尿病患病率和药物使用的影响
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100062
Ying-Ying Meng , Yu Yu , Susan H. Babey , Jason Su

Background

Type 2 diabetes has raised great public health concerns due to its association with the increased risk of several adverse health outcomes. We aimed to investigate the association of criteria air pollutants and traffic density with the prevalence of type 2 diabetes and antidiabetic medication use in California.

Methods

A cross-sectional study was conducted using 2005 California Health Interview Survey (CHIS) data, linked with criteria air pollutant exposure measures, including government-monitored ozone (O3), particulate matter (PM10, PM2.5) and nitrogen dioxide (NO2), residential traffic density, and land use regression modeled NOX, NO, and NO2 estimates for Los Angeles County only based on the respondents’ geocoded residential addresses. Weighted logistic regression models were used to examine the influences of 36-month average exposures to each air pollutant and traffic density on diabetes prevalence and medication use.

Results

Among 31,483 CHIS 2005 state-wide respondents, 6.7% of adults reported having been diagnosed with type 2 diabetes. We observed type 2 diabetes prevalence was positively associated with exposures to O3, PM10, and PM2.5, and with NO, NO2, and NOx only in Los Angeles County. For each 10ppb increase in O3 or 10ug/m3 increase in PM10 or PM2.5, the odds of taking any medication increased by 40%, 56%, and 50%; taking pills increased by 33%, 31%, and 41%; taking insulin increased by 43%, 53%, and 46%; and taking both insulin and pills increased by 70%, 60%, and 88%, respectively. When traffic density within 750 feet of a respondent's home increased by one interquartile, 7% increase in odds of using any medication and taking pills was also observed.

Conclusion

This study adds to evidence indicating greater air pollution exposure is associated with increased diabetes prevalence. It also provides new evidence demonstrating a strong association between pollutant exposure and antidiabetic medication use in adult Californians.

背景:2型糖尿病与几种不良健康结果的风险增加有关,引起了公众对其健康的高度关注。我们的目的是调查加州标准空气污染物和交通密度与2型糖尿病患病率和抗糖尿病药物使用的关系。方法利用2005年加州健康访谈调查(CHIS)数据进行了一项横断面研究,并与标准空气污染物暴露措施相关联,包括政府监测的臭氧(O3)、颗粒物(PM10、PM2.5)和二氧化氮(NO2)、住宅交通密度,以及仅基于受访者地理代码的洛杉矶县NOX、NO和NO2估算的土地利用回归模型。采用加权logistic回归模型检验了36个月平均暴露于每种空气污染物和交通密度对糖尿病患病率和药物使用的影响。结果在2005年CHIS的31483名全州受访者中,6.7%的成年人报告被诊断为2型糖尿病。我们观察到,仅在洛杉矶县,2型糖尿病的患病率与O3、PM10和PM2.5以及NO、NO2和NOx的暴露呈正相关。臭氧浓度每增加10ppb或PM10或PM2.5浓度每增加10ug/m3,服用任何药物的几率分别增加40%、56%和50%;服药人数分别增加了33%、31%和41%;胰岛素使用量分别增加了43%、53%和46%;同时服用胰岛素和药片的人数分别增加了70%、60%和88%。当被调查者家周围750英尺范围内的交通密度增加一个四分之一时,使用任何药物和服用药片的几率也会增加7%。结论:该研究进一步证明,暴露在空气污染中与糖尿病患病率增加有关。该研究还提供了新的证据,证明加州成年人接触污染物与使用抗糖尿病药物之间存在密切联系。
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引用次数: 0
Artificial intelligence in heavy metals detection: Methodological and ethical challenges 重金属检测中的人工智能:方法和伦理挑战
Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100071
Nidhi Yadav , Brij Mohan Maurya , Dewan Chettri , Pooja , Chirag Pulwani , Mahesh Jajula , Savleen Singh kanda , Harysh Winster Suresh babu , Ajay Elangovan , Parthasarathy Velusamy , Mahalaxmi Iyer , Balachandar Vellingiri

Heavy metals (HMs) are metallic substances. They enter biotic and abiotic systems through natural and human activities. These HMs have an impact on the atmosphere, soil, and groundwater, and they also affect all living things, especially humans, when they enter the food chain. Therefore, monitoring and removing HMs from the environment and humans are crucial for maintaining HMs-based toxicity. The detection of HMs from environmental and human samples has been performed by techniques such as atomic adsorption spectrometry (AAS) and inductively coupled plasma mass spectrometry (ICP-MS). With the advancement of AI-based technology, HMs are now detected and removed from the environment and human systems. This review discusses the impact of HMs on the environment and human health, their detection and removal techniques, and the integration of recent advancements in AI-based technology for the detection and removal of HMs from environmental and human samples.

重金属是一种金属物质。它们通过自然和人类活动进入生物和非生物系统。这些有机污染物对大气、土壤和地下水都有影响,当它们进入食物链时,也会影响所有生物,尤其是人类。因此,监测并从环境和人类中清除HMs对于维持HMs毒性至关重要。原子吸附光谱法(AAS)和电感耦合等离子体质谱法(ICP-MS)等技术对环境和人体样品中的HMs进行了检测。随着基于人工智能的技术的进步,现在可以从环境和人类系统中检测并清除HMs。本文讨论了HMs对环境和人类健康的影响,它们的检测和去除技术,以及基于人工智能的技术在环境和人类样本中检测和去除HMs的最新进展。
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Hygiene and environmental health advances
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