Hygiene and environmental health advances最新文献

{"title":"Plant-driven strategies for mitigating microplastic pollution in agricultural ecosystems","authors":"Anindita Banerjee ,&nbsp;Pranav Kumar ,&nbsp;Arkaprobha Ghosh ,&nbsp;Soumita Reja ,&nbsp;Surjit Singh","doi":"10.1016/j.heha.2025.100160","DOIUrl":"10.1016/j.heha.2025.100160","url":null,"abstract":"<div><div>Microplastics (MPs) have become a widespread and novel threat to agriculture by degrading soils, damaging plant productivity and ultimately threatening food security. Research on MP contamination paths through plastic mulching, biosolids, compost, and wastewater irrigation has led to a greater understanding the problem, but the physiological and ecological impacts on plants have not been quantified and explained. MPs affect the biophysical properties of the soils, including the water and nutrients, which impacts their flow to the MP-affected plants. Biophysical changes caused by the MPs to the soils include changes to bulk density, porosity, and hydraulic conductivity. In the rhizosphere, they cause disruption to the microbial networks, suppression of enzymes, and the destabilization of symbiotic relationships, which impacts the plants’ ability to biogoechemically cycle and mitigate stress. MP-affected plants result in reduced germination, depressed photosynthetic productivity, oxidative stress leading to altered carbon distribution, secondary metabolites, and loss of other metabolites.</div><div>While there are many studies on the microbial and physicochemical approaches to remediation, the plant pathway and approaches to remediation are still largely unexplored and present a novel opportunity to address the problem. Symbiotic microbial consortia associated with root systems will help with enzymatic transformation of aggregating, immobilizing, and in some cases, biochemically transforming MPs. The detoxification capacity of PGPR and rhizosphere biochar are often situational and short-lived. Most importantly, the short-term laboratory studies using pristine MPs and over concentrated MPs will not accurately influence or predict the ecological impact and applicability to the field.</div><div>This review underscores the need for an integrated, nature-based strategies to combat MP pollution and protect agroecosystem integrity by bridging microbiology, soil science, and sustainable agriculture. Furthermore, a comprehensive understanding of the root system physiology, chemical exudation patterns, and microbial associations has been explored to determine the fate of the MP in deriving implementable plant-driven approaches. Such a framework is necessary to develop resilient self-remediating agroecosystems that can degrade plastic waste while maintaining productive agriculture.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100160"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorooctanoic acid impairs myogenic differentiation and muscle function via activation of the hippo-YAP pathway in mice and C2C12 myoblasts","authors":"Gaowei Duan ,&nbsp;Hong Hong ,&nbsp;Yuanhang Liu ,&nbsp;He Xiao ,&nbsp;Yuan Ding ,&nbsp;Muhammad Amjad ,&nbsp;Peixuan Wu ,&nbsp;Li Zhong ,&nbsp;Xu Wang ,&nbsp;Xin Meng ,&nbsp;Haiyan Zhang","doi":"10.1016/j.heha.2025.100162","DOIUrl":"10.1016/j.heha.2025.100162","url":null,"abstract":"<div><div>Perfluorooctanoic acid (PFOA), a widely distributed environmental pollutant, exerts toxic effects on multiple human organs and tissues. However, its impact on skeletal muscle function and the underlying molecular mechanisms remain poorly understood. In this study, we first observed that PFOA exposure caused muscle dysfunction in juvenile mice, characterized by reduced grip strength and impaired motor coordination; to explore the underlying mechanism, we further conducted in vitro experiments using C2C12 myoblasts. Long-term treatment with 100 μacid (PFOA), a widely distributed environmental pollutant, exerts toxic effects on multiple human organs and tissues. However, its impact on myotubes. Transcriptome sequencing revealed a significant decrease in the expression of key myogenic regulatory factors (e.g., myosin heavy chain MYHC and myogenin) in PFOA-treated cells, findings that were confirmed by RT-qPCR and Western blot analyses. Mechanistically, PFOA treatment activated the Hippo signaling pathway, as evidenced by increased phosphorylation of the YAP protein. Treatment with taurine, an indirect activator of YAP, significantly restored the expression of myogenic genes and effectively promoted myotube formation. In summary, this study demonstrates that PFOA impairs muscle function by activating the Hippo signaling pathway and suppressing the transcription of key myogenic factors, providing new insights into PFOA-induced myotoxicity.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"17 ","pages":"Article 100162"},"PeriodicalIF":2.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated burden of disease and health effects attributable to fine particulate matter and ozone exposure in relation to COPD and cardiovascular disease in Upper Northern Thailand","authors":"Sarawut Sangkham ,&nbsp;Nattapon Pansakun ,&nbsp;Patipat Vongruang ,&nbsp;Mohammad Nayeem Hasan ,&nbsp;Saksin Simsin","doi":"10.1016/j.heha.2025.100161","DOIUrl":"10.1016/j.heha.2025.100161","url":null,"abstract":"<div><div>Fine particulate matter (PM_2.5) is a significant contributor to air pollution and is associated with many diseases of global public health concern. In this study, the burden of lung cancer and cardiopulmonary disease attributed to PM_2.5 exposure in Thailand's upper northern region is estimated. Additionally, generalised additive models (GAMs) were used to examine the relationship between PM_2.5 and ozone (O₃) levels and the incidence of cardiovascular diseases (CVDs) and chronic obstructive pulmonary disease (COPD). The results indicated all eight provinces showed a positive relative risk (RR) for lung cancer and cardiopulmonary disease. The estimated long-term exposure to PM_2.5 during 2015–2023 showed that the regional average relative risk (RR) was 1.558 (95 % CI: 1.530–1.586) for lung cancer and 1.344 (95 % CI: 1.328–1.361) for cardiopulmonary disease. This study examined the short-term effects of PM_2.5 and ozone (O₃) exposure on morbidity from COPD and CVD. PM_2.5 exposure was significantly associated with increased COPD risk only in Lampang province, where the incidence rate ratio [IRR] was 1.009 (95 % CI: 1.002–1.017), <em>p</em> &lt; 0.05. Ozone exposure showed significant associations with COPD risk in Chiang Mai, Chiang Rai, and Nan provinces, with the IRRs of 1.021 (95 % CI: 1.009–1.033), 1.020 (95 % CI: 1.007–1.032), and 1.026 (95 % CI: 1.012–1.040), respectively (<em>p</em> &lt; 0.05). Ozone exposure was associated with an increased IRR for CVD risk in Chiang Mai, Chiang Rai, and Nan provinces; however, the association was not statistically significant. In contrast, no significant association in IRR was observed for short-term PM_2.5 exposure in relation to CVD. Joint exposure to PM_2.5 and O₃ was significantly associated with increased risk of COPD in Chiang Mai, Chiang Rai, and Nan provinces (<em>p</em> &lt; 0.05). Interaction analyses revealed synergistic effects on COPD in Nan and CVD in Chiang Rai and Nan. Male sex, older age (≥ 60 years), and seasonal variation of particulate matter and ozone concentration were identified as significant effect modifiers. These findings elucidate the differential impacts of air pollutants on respiratory and cardiovascular health in upper northern Thailand. Furthermore, they emphasise the heightened vulnerability of older adults and males, underscoring the urgent need for targeted, region-specific public health interventions.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"17 ","pages":"Article 100161"},"PeriodicalIF":2.7,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-existing pulmonary function abnormality exacerbates the impact of occupational dust exposure on incident hypertension: Evidence from a large occupational cohort","authors":"Zhongzhi Xu ,&nbsp;Xin Xu ,&nbsp;Shao Lin ,&nbsp;Bing Xia ,&nbsp;Shanyu Zhou ,&nbsp;Shu Wang ,&nbsp;Yawei Guo ,&nbsp;Lulu Lin ,&nbsp;Huiyuan Zhong ,&nbsp;Lerong Liu ,&nbsp;Yongshun Huang ,&nbsp;Wangjian Zhang","doi":"10.1016/j.heha.2025.100157","DOIUrl":"10.1016/j.heha.2025.100157","url":null,"abstract":"<div><div>This study aimed to examine the independent and joint effects of occupational dust exposure (ODE) and pulmonary function abnormalities (PFA) on the incidence of hypertension, and to assess whether pre-existing PFA modifies the ODE–hypertension relationship. A prospective cohort design was used, drawing data from the Guangdong Key Occupational Diseases Surveillance Project (2021–2023), which included 144,627 workers from 21 cities in Guangdong, China. ODE and PFA were assessed using standardized protocols, and hypertension was defined as elevated blood pressure or use of antihypertensive medication. Cox proportional hazards models, restricted cubic splines, and interaction analyses were performed to evaluate associations, and Mendelian randomization (MR) using UK Biobank data was conducted to assess causality. At baseline, 33,766 participants (23.3 %) had PFA, and during follow-up, 14,996 (10.4 %) developed hypertension. Both ODE (HR = 1.12, 95 % CI: 1.08–1.16) and PFA (HR = 1.19, 95 % CI: 1.14–1.23) were independently associated with increased hypertension risk (<em>P</em> &lt; 0.001), with a higher combined effect (HR = 1.39, 95 % CI: 1.31–1.47). A positive trend was observed between dust exposure duration and hypertension risk (HR = 1.11 for ≥6 years vs. &lt;2 years; <em>P</em> for trend = 0.017). Respirable dust (≤10 μm) and inorganic dust were significantly associated with increased hypertension risk (HR = 1.16 and 1.13). MR analysis supported a causal relationship between ODE, PFA, and hypertension. These findings indicate that pre-existing PFA amplifies the hypertensive effects of ODE, highlighting the importance of respiratory health interventions to reduce hypertension risk among dust-exposed workers.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100157"},"PeriodicalIF":2.7,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What drives toilet cleanliness in urban schools? Roles of infrastructure, resources, and hygiene promotion in Kampala","authors":"Jude Zziwa Byansi ,&nbsp;Swaib Semiyaga ,&nbsp;Alex Yasoni Katukiza ,&nbsp;Najib Lukooya Bateganya ,&nbsp;Frank Kansiime ,&nbsp;Robinah Nakawunde Kulabako","doi":"10.1016/j.heha.2025.100158","DOIUrl":"10.1016/j.heha.2025.100158","url":null,"abstract":"<div><div>Access to clean toilets in schools is essential for a conducive learning environment and safeguarding pupils' health. Urban schools often face sanitation challenges stemming from overcrowding, inadequate facilities, and differences in management practices across school categories such as public or private, primary or secondary, day or boarding, and service level classifications. Identifying key factors influencing toilet cleanliness is vital for improving urban school sanitation. This study investigated the drivers of toilet cleanliness through a cross-sectional study conducted in Kampala City, in Uganda. Kampala City has 852 schools of which 274 were selected for this study. Data collection comprised 274 structured observations guided by a checklist, 548 questionnaires administered to Head Teachers and Sanitation Teachers, and 40 key informant interviews. Logistic regression and decision tree modeling were used for data analysis. Across all school types, significant associations were observed between toilet cleanliness and facility privacy, sex segregation, presence of health clubs, handwashing facilities with soap and water, rainwater harvesting systems, sanitation budget, and toilet paper availability. The decision tree model identified rainwater harvesting, handwashing facilities, and health clubs as the strongest predictors of toilet cleanliness, in that order. Findings indicate that policymakers and school administrators should prioritize investment in water access, hygiene infrastructure, and health clubs to improve and sustain toilet cleanliness in urban schools.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100158"},"PeriodicalIF":2.7,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to cadmium and cerebrovascular mortality in the United States","authors":"Xin Wang ,&nbsp;Ziqin Cao ,&nbsp;Kelly M. Bakulski ,&nbsp;Henry L. Paulson","doi":"10.1016/j.heha.2025.100156","DOIUrl":"10.1016/j.heha.2025.100156","url":null,"abstract":"<div><h3>Background</h3><div>Cerebrovascular diseases are a leading cause of death in the U.S., and emerging evidence suggests that environmental toxicants such as cadmium may contribute to cerebrovascular risk. This study investigates the association between cadmium exposure and cerebrovascular mortality in a nationally representative sample of U.S. adults.</div></div><div><h3>Methods</h3><div>We analyzed data from adults aged ≥40 years in the National Health and Nutrition Examination Survey (NHANES) 1999–2016 cycles, with mortality follow-up through 2019. Blood cadmium was measured in 23,455 participants, and urinary cadmium was measured in 8929 participants. Cerebrovascular deaths were identified through linkage with the National Death Index. Survey-weighted Cox proportional hazards models evaluated associations between cadmium concentrations and cerebrovascular mortality.</div></div><div><h3>Results</h3><div>Over a mean follow-up of 10.2 years, 247 cerebrovascular deaths were observed. Each interquartile range increase in blood cadmium (0.40 µg/L) was associated with a 23 % higher risk of cerebrovascular mortality (HR = 1.23, 95 % CI: 1.04–1.46). Urinary cadmium was also associated with higher cerebrovascular mortality, although marginally significant (HR = 1.36 per doubling, 95 % CI: 0.99–1.87). Associations appeared stronger among former and current smokers, though interaction terms were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Cadmium exposure is associated with increased cerebrovascular mortality in the U.S. population. These findings support cadmium as a modifiable environmental risk factor and underscore the need for public health interventions to reduce exposure through tobacco control, dietary regulations, and environmental policy.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100156"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of particulate matter exposure associated with biomass storage in urban heating plant","authors":"Daniel Tomčík ,&nbsp;Miloš Gejdoš","doi":"10.1016/j.heha.2025.100154","DOIUrl":"10.1016/j.heha.2025.100154","url":null,"abstract":"<div><div>This study assessed the airborne particulate matter (PM) in urban heating plants, potentially affecting respiratory health in workers and nearby residents. The objectives of this study were to characterize occupational exposure during chip-loading activities and to evaluate ambient PM concentrations in the surrounding environment. Occupational exposure was assessed in accordance with the relevant standards using the Temtop M2000C, while continuous ambient monitoring was conducted with the AirNote device. The results indicate a significant increase in PM concentrations during woodchip loading activities. Mean PM2.5 concentrations were 24.03 µg/m³ during loading and 8.07 µg/m³ during non-loading, while PM10 levels were 38.75 µg/m³ and 12.80 µg/m³, respectively. Continuous monitoring revealed that daily mean PM2.5 concentrations were above the WHO 24-h guideline value of 15 µg/m³ on 3 days. The maximum daily mean PM2.5 concentration was 43.7 µg/m³, while the median daily mean was 22.5 µg/m³. For PM10, the maximum daily mean reached 70.9 µg/m³ and the median daily mean was 35.6 µg/m³, with exceedance of the WHO 24-hour guideline of 45 µg/m³ observed on one day. Distance from the woodchip pile also had a significant effect on PM concentrations (<em>p</em> &lt; 0.001), with short-term mean levels at 50 m exceeding the WHO 24-h guideline value by 2.9 times for PM2.5 and 1.6 times for PM10. These guideline values are provided for context only, as they represent 24-hour mean concentrations and not instantaneous limits. Beyond 100 m, no further significant reduction in PM levels was observed. Biomass storage operations can cause temporary PM exceedances, particularly during handling and near storage areas. These findings underscore the importance of implementing mitigation strategies to reduce airborne particulate emissions.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100154"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution mixtures and stillbirth: k-means cluster analysis","authors":"Naomi O. Riches ,&nbsp;Ramkiran Gouripeddi ,&nbsp;Robert M. Silver ,&nbsp;Julio C. Facelli","doi":"10.1016/j.heha.2025.100153","DOIUrl":"10.1016/j.heha.2025.100153","url":null,"abstract":"<div><h3>Background</h3><div>Preventing stillbirths starts with identifying modifiable risk factors, such as air pollution (AP). Most research has focused on individual components of AP (e.g. PM_2.5) to assess the linear relationship between air pollutant concentration and stillbirth, with mixed results. However, the air we breathe is a mixture of gases and particles. The purpose of this study was to assess how mixtures of criteria air pollutants are associated with stillbirth in the United States.</div></div><div><h3>Materials and Methods</h3><div>Air pollution data from the US Environmental Protection Agency and individual US birth and fetal death data from the CDC National Vital Statistics System were used. Air pollutant exposures were clustered using k-means clustering. A categorical variable linking each patient to one of these clusters was used in a regression analysis.</div></div><div><h3>Results</h3><div>Four AP clusters were identified through k-means. Exposure to air pollution mixtures included in Clusters 1, 2, and 4 during pregnancy was associated with a 40%, 13%, and 43% increase in the odds of stillbirth, compared to Cluster 3 (reference), (OR = 1.40, 95% CI: 1.36-1.44, p&lt;0.001; OR = 1.13, 95% CI: 1.09-1.16, p&lt;0.001; OR = 1.43, 95% CI: 1.38-1.49, p&lt;0.001), respectively.</div></div><div><h3>Discussion</h3><div>The air pollution cluster associated with the greatest odds of stillbirth was high in PM_2.5 and SO₂, which may indicate industrial sources. To our knowledge, this is the first study to assess the impact of air pollution mixtures on stillbirth using k-means clustering. This method can be used to identify non-linear relationships between mixtures of air pollution and a health outcome.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100153"},"PeriodicalIF":2.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood cadmium and lead concentrations in association with homocysteine and all-cause and cardiovascular mortality","authors":"Shaohui Liu ,&nbsp;Ziqi Zeng ,&nbsp;Quanhong Chen ,&nbsp;Anan Zhou ,&nbsp;Yunan Xu ,&nbsp;Hao Chen ,&nbsp;Yunfeng Zou","doi":"10.1016/j.heha.2025.100148","DOIUrl":"10.1016/j.heha.2025.100148","url":null,"abstract":"<div><div>Cadmium and lead exposure are reported to associate with elevated plasma homocysteine concentrations. However, whether homocysteine plays a role in the associations of cadmium and lead with all-cause and cardiovascular mortality is unclear. We conducted a cohort study using data from 6456 participants in the National Health and Nutrition Examination Survey (NHANES) (2003–2006). Cox regression models and restricted cubic splines (RCS) were used to examine the associations between cadmium, lead, and homocysteine and all-cause and cardiovascular mortality. Mediation analysis was conducted to evaluate the indirect effect of homocysteine in the associations between cadmium, lead and all-cause and cardiovascular mortality. During a median of 14.33 years of follow-up, 1642 (25.43 %) all-cause deaths and 575 (8.91 %) cardiovascular deaths were observed. When compared with the first quartile, cadmium, lead, and homocysteine levels in the fourth quartile were associated with increased all-cause mortality risk [hazard ratios (HRs) with 95 % confidence interval (CI) 1.91 (1.60, 2.29), 1.38 (1.16, 1.64), and 1.74 (1.42, 2.14), respectively] and cardiovascular mortality [1.85 (1.37, 2.50), 1.55 (1.15, 2.09), 1.67 (1.17, 2.37), respectively]. RCS analysis suggested nonlinear associations of cadmium, lead, and homocysteine with all-cause mortality, nonlinear relationships between cadmium and cardiovascular mortality, and linear associations between lead, homocysteine and cardiovascular mortality. Changes in homocysteine levels accounted for approximately 4.11 % and 5.81 % of the observed associations between cadmium exposure and all-cause and cardiovascular mortality, respectively. Similar observations were made for homocysteine on the associations of lead exposure and all-cause (11.05 %) and cardiovascular (7.69 %) mortality. Furthermore, lead concentrations modified the associations of cadmium and homocysteine with cardiovascular and all-cause mortality. Our findings suggested that plasma homocysteine was associated with the observed relationships between cadmium and lead exposure and increased all-cause and cardiovascular mortality, potentially reflecting underlying pathways relevant to heavy metal-related cardiovascular risk.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100148"},"PeriodicalIF":2.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling co-contamination characteristics of heavy metals in soil-crop system and collaborative management of their health risk across China","authors":"Wenzhuo Deng ,&nbsp;Fei Li ,&nbsp;Xiyao Chen ,&nbsp;Jinyuan Guo ,&nbsp;Chang Gao ,&nbsp;Junrui Zhao ,&nbsp;Tianwei Sun ,&nbsp;Jingdong Zhang","doi":"10.1016/j.heha.2025.100151","DOIUrl":"10.1016/j.heha.2025.100151","url":null,"abstract":"<div><div>Heavy metal pollution in farmland soil and crops directly affects the food safety and public health. A comprehensive national-scale assessment from an integrated soil-crop perspective in China remains limited. To address this gap, this study conducted a systematic review using an optimized bibliometric approach enhanced with uncertainty control and case mining. 1157 publications reporting on eight heavy metals (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) in agricultural soils, grains, and vegetables across China were analyzed. Key findings include: (1) Cadmium (Cd) was the most widespread pollutant in soils, whereas mercury (Hg) showed highly concentrated hotspots. (2) A discrepancy was observed between soil pollution levels and the corresponding crop contamination indicating that the relationship between them is not fully synergistic. (3) Health risk assessment revealed that the total carcinogenic risk from soil exposure (10⁻⁶ - 10⁻⁵) was significantly lower than that from ingestion of contaminated grains and vegetables (10⁻⁴ - 10⁻³). Arsenic (As) and Cd were identified as the primary risk contributors in most provinces. (4) Geographically, integrated high-risk areas were classified as Class I (Guangdong, Guizhou, Yunnan) and Class II (Hunan). Risk sources in Yunnan and Guizhou were attributed to both geogenic and anthropogenic activities, with exposure dominated by vegetable and grain ingestion, respectively. In contrast, risks in Guangdong and Hunan were primarily linked to human activities (industrial, mining, and agricultural), with comparable exposure from both crops. Based on these findings, tailored risk mitigation strategies are proposed for the identified high-risk provinces, considering their distinct exposure pathways and contamination sources.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"16 ","pages":"Article 100151"},"PeriodicalIF":2.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}