Hygiene and environmental health advances最新文献_第2页

Analyzing novel crowdsourced data sources and their role in understanding health outcomes of climate change-driven disasters 分析新的众包数据源及其在了解气候变化驱动的灾害的健康后果方面的作用

IF 2.7

Hygiene and environmental health advances

Pub Date : 2026-03-01 Epub Date: 2026-01-02 DOI: 10.1016/j.heha.2026.100167

Ramya S. Nayaka , Jennifer L. Chan , Michael S. Bloom , Hemant Purohit

Climate change has increased the frequency and severity of natural disasters that pose significant mental and physical health risks to the public during and after the event. Simultaneously, the dependency on social media to provide real-time information on how a disaster unfolds has also grown. We performed a scoping review using the Arksey and O’Malley framework to identify how crowdsourced data from social media platforms from the year 2010 to 2024 can be used to understand health outcomes during climate change-driven natural disasters in the United States. We reviewed thirty-four peer-reviewed articles using an interdisciplinary multi-method approach of human-machine collaboration. Two key research questions guided the review: (1) How is social media used to inform early warning systems for public health risks during climate-related disasters? and (2) Do social media indicators reflect disparities in health outcomes across different populations and geographic regions in such disaster events? The scoping review revealed four dominant thematic areas where the value of social media has been demonstrated: Health Concerns, Affected Populations, Disaster Impact & Response, and Environmental Factors. Social media platforms have frequently supported early warning efforts and detection of health risks, offering real-time insights into public perceptions and changing situations on the ground. Our findings highlight the value of social media as a complementary tool for real-time surveillance of disaster situations and public health response. The insights from social media can support timely action by public health officials, emergency services, nonprofits, and volunteers to plan and act efficiently during disaster response and relief. Future research should focus on extracting granular health-related information from social media data to enhance disaster response effectiveness and support for affected communities.

气候变化增加了自然灾害发生的频率和严重程度，在灾害发生期间和之后对公众的身心健康构成重大风险。与此同时，人们对社交媒体提供灾难如何展开的实时信息的依赖也在增加。我们使用Arksey和O 'Malley框架进行了范围审查，以确定如何使用2010年至2024年来自社交媒体平台的众包数据来了解美国气候变化驱动的自然灾害期间的健康结果。我们使用人机协作的跨学科多方法方法回顾了34篇同行评议的文章。两个关键的研究问题指导了这次审查：(1)在气候相关灾害期间，如何利用社交媒体为公共卫生风险预警系统提供信息？(2)在此类灾害事件中，社交媒体指标是否反映了不同人群和地理区域之间健康结果的差异？范围审查揭示了社会媒体价值已得到证明的四个主要专题领域：健康问题、受影响人口、灾害影响和应对以及环境因素。社交媒体平台经常支持早期预警工作和健康风险检测，提供对公众看法和实地情况变化的实时洞察。我们的研究结果强调了社交媒体作为实时监测灾害情况和公共卫生反应的补充工具的价值。来自社交媒体的见解可以支持公共卫生官员、应急服务机构、非营利组织和志愿者及时采取行动，在灾难响应和救济期间有效地制定计划和采取行动。未来的研究应侧重于从社交媒体数据中提取与健康相关的详细信息，以提高救灾效率和对受影响社区的支持。

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引用次数: 0

Unraveling co-contamination characteristics of heavy metals in soil-crop system and collaborative management of their health risk across China 中国土壤-作物系统重金属共污染特征及其健康风险协同管理

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.heha.2025.100151

Wenzhuo Deng , Fei Li , Xiyao Chen , Jinyuan Guo , Chang Gao , Junrui Zhao , Tianwei Sun , Jingdong Zhang

Heavy metal pollution in farmland soil and crops directly affects the food safety and public health. A comprehensive national-scale assessment from an integrated soil-crop perspective in China remains limited. To address this gap, this study conducted a systematic review using an optimized bibliometric approach enhanced with uncertainty control and case mining. 1157 publications reporting on eight heavy metals (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) in agricultural soils, grains, and vegetables across China were analyzed. Key findings include: (1) Cadmium (Cd) was the most widespread pollutant in soils, whereas mercury (Hg) showed highly concentrated hotspots. (2) A discrepancy was observed between soil pollution levels and the corresponding crop contamination indicating that the relationship between them is not fully synergistic. (3) Health risk assessment revealed that the total carcinogenic risk from soil exposure (10⁻⁶ - 10⁻⁵) was significantly lower than that from ingestion of contaminated grains and vegetables (10⁻⁴ - 10⁻³). Arsenic (As) and Cd were identified as the primary risk contributors in most provinces. (4) Geographically, integrated high-risk areas were classified as Class I (Guangdong, Guizhou, Yunnan) and Class II (Hunan). Risk sources in Yunnan and Guizhou were attributed to both geogenic and anthropogenic activities, with exposure dominated by vegetable and grain ingestion, respectively. In contrast, risks in Guangdong and Hunan were primarily linked to human activities (industrial, mining, and agricultural), with comparable exposure from both crops. Based on these findings, tailored risk mitigation strategies are proposed for the identified high-risk provinces, considering their distinct exposure pathways and contamination sources.

农田土壤和农作物重金属污染直接影响食品安全和公众健康。在中国，从土壤-作物综合角度进行全国范围的综合评估仍然有限。为了解决这一差距，本研究使用优化的文献计量学方法进行了系统回顾，并加强了不确定性控制和案例挖掘。分析了中国农业土壤、粮食和蔬菜中8种重金属（As、Cd、Cr、Cu、Hg、Ni、Pb和Zn）的1157份出版物。主要发现包括：(1)镉（Cd）是土壤中分布最广的污染物，而汞（Hg）则呈现高度集中的热点。(2)土壤污染水平与作物污染水平之间存在差异，表明两者之间的关系并非完全协同。(3)健康风险评估显示，接触土壤（10⁻6 - 10⁻5）的总致癌风险明显低于摄入受污染的谷物和蔬菜（10⁻4 - 10⁻3）。在大多数省份，砷（As）和镉被确定为主要的危险因素。(4)综合高风险区域在地理上划分为一类（广东、贵州、云南）和二类（湖南）。云南和贵州的风险源主要为地质和人为活动，暴露主要为蔬菜和谷物摄入。相比之下，广东和湖南的风险主要与人类活动（工业、采矿和农业）有关，两种作物的风险相当。在此基础上，针对已确定的高风险省份，考虑到其不同的暴露途径和污染源，提出了量身定制的风险缓解策略。

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引用次数: 0

HEHA editorial - Perspectives on climate change and health HEHA社论-对气候变化和健康的看法

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.heha.2025.100150

Shao Lin , Michael S. Bloom , Guang-Hui Dong , Samantha Friedman , Wenjun Ma , Di Wu , Xiaobo Romeiko , Jennifer Manganello , Xiaojun Yuan , DeeDee Bennett Gayle

引用次数: 0

Assessing the longitudinal impact of environmental chemical mixtures on children’s neurodevelopment: A Bayesian approach 评估环境化学混合物对儿童神经发育的纵向影响：贝叶斯方法

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-09-09 DOI: 10.1016/j.heha.2025.100146

Wei Jia , Aimin Chen , Kimberly Yolton , Yingying Xu , He Lili , Roman A. Jandarov

This manuscript presents a novel Bayesian varying coefficient quantile regression (BVCQR) model designed to assess the longitudinal effects of chemical exposure mixtures on children’s neurodevelopment. Recognizing the complexity and high-dimensionality of environmental exposures, the proposed approach addresses critical gaps in existing research by offering a method that can manage the sparsity of data and provide interpretable results. The proposed BVCQR model estimates the effects of mixtures on neurodevelopmental outcomes at specific ages, leveraging a horseshoe prior for sparsity and utilizing a Bayesian method for uncertainty quantification. Our simulations demonstrate the model’s robustness and effectiveness in handling high-dimensional data, offering significant improvements over traditional models. The model’s application to the Health Outcomes and Measures of the Environment (HOME) Study further illustrates its utility in identifying significant chemical exposures affecting children’s growth and development. The findings underscore the potential of BVCQR in environmental health research, providing a sophisticated tool for analyzing the longitudinal impact of complex chemical mixtures, with implications for future studies aimed at understanding and mitigating environmental risks to child health.

本文提出了一种新的贝叶斯变系数分位数回归（BVCQR）模型，旨在评估化学接触混合物对儿童神经发育的纵向影响。认识到环境暴露的复杂性和高维性，提出的方法通过提供一种可以管理数据稀疏性并提供可解释结果的方法来解决现有研究中的关键空白。提出的BVCQR模型估计了特定年龄的混合对神经发育结果的影响，利用马蹄形先验进行稀疏性，并利用贝叶斯方法进行不确定性量化。我们的仿真证明了该模型在处理高维数据方面的鲁棒性和有效性，与传统模型相比有了显著的改进。该模型在环境健康结果和措施研究（HOME）中的应用进一步说明了它在确定影响儿童生长和发育的重大化学品接触方面的效用。研究结果强调了BVCQR在环境卫生研究中的潜力，为分析复杂化学混合物的纵向影响提供了一个复杂的工具，对旨在了解和减轻环境对儿童健康的风险的未来研究具有启示意义。

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引用次数: 0

Pre-existing pulmonary function abnormality exacerbates the impact of occupational dust exposure on incident hypertension: Evidence from a large occupational cohort 先前存在的肺功能异常加剧了职业性粉尘暴露对高血压事件的影响：来自大型职业队列的证据

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-11-09 DOI: 10.1016/j.heha.2025.100157

Zhongzhi Xu , Xin Xu , Shao Lin , Bing Xia , Shanyu Zhou , Shu Wang , Yawei Guo , Lulu Lin , Huiyuan Zhong , Lerong Liu , Yongshun Huang , Wangjian Zhang

This study aimed to examine the independent and joint effects of occupational dust exposure (ODE) and pulmonary function abnormalities (PFA) on the incidence of hypertension, and to assess whether pre-existing PFA modifies the ODE–hypertension relationship. A prospective cohort design was used, drawing data from the Guangdong Key Occupational Diseases Surveillance Project (2021–2023), which included 144,627 workers from 21 cities in Guangdong, China. ODE and PFA were assessed using standardized protocols, and hypertension was defined as elevated blood pressure or use of antihypertensive medication. Cox proportional hazards models, restricted cubic splines, and interaction analyses were performed to evaluate associations, and Mendelian randomization (MR) using UK Biobank data was conducted to assess causality. At baseline, 33,766 participants (23.3 %) had PFA, and during follow-up, 14,996 (10.4 %) developed hypertension. Both ODE (HR = 1.12, 95 % CI: 1.08–1.16) and PFA (HR = 1.19, 95 % CI: 1.14–1.23) were independently associated with increased hypertension risk (P < 0.001), with a higher combined effect (HR = 1.39, 95 % CI: 1.31–1.47). A positive trend was observed between dust exposure duration and hypertension risk (HR = 1.11 for ≥6 years vs. <2 years; P for trend = 0.017). Respirable dust (≤10 μm) and inorganic dust were significantly associated with increased hypertension risk (HR = 1.16 and 1.13). MR analysis supported a causal relationship between ODE, PFA, and hypertension. These findings indicate that pre-existing PFA amplifies the hypertensive effects of ODE, highlighting the importance of respiratory health interventions to reduce hypertension risk among dust-exposed workers.

本研究旨在探讨职业性粉尘暴露（ODE）和肺功能异常（PFA）对高血压发病率的独立和联合影响，并评估先前存在的PFA是否会改变ODE与高血压的关系。采用前瞻性队列设计，数据来源于广东省重点职业病监测项目（2021-2023），包括来自广东省21个城市的144,627名劳动者。采用标准化方案评估ODE和PFA，并将高血压定义为血压升高或使用抗高血压药物。采用Cox比例风险模型、受限三次样条和相互作用分析来评估相关性，并使用UK Biobank数据进行孟德尔随机化（MR）来评估因果关系。在基线时，33,766名参与者（23.3%）患有PFA，在随访期间，14,996名参与者（10.4%）患有高血压。ODE （HR = 1.12, 95% CI: 1.08-1.16）和PFA （HR = 1.19, 95% CI: 1.14-1.23）与高血压风险增加独立相关（P < 0.001），合并效应更高（HR = 1.39, 95% CI: 1.31-1.47）。粉尘暴露时间与高血压风险呈正相关（≥6年HR = 1.11 vs. 2年P = 0.017）。呼吸性粉尘（≤10 μm）和无机粉尘与高血压风险增加显著相关（HR = 1.16和1.13）。磁共振分析支持ODE、PFA和高血压之间的因果关系。这些研究结果表明，先前存在的PFA放大了ODE的高血压效应，强调了呼吸健康干预措施对降低粉尘暴露工人高血压风险的重要性。

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引用次数: 0

Exposure to cadmium and cerebrovascular mortality in the United States 美国的镉暴露与脑血管死亡率

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI: 10.1016/j.heha.2025.100156

Xin Wang , Ziqin Cao , Kelly M. Bakulski , Henry L. Paulson

Background

Cerebrovascular diseases are a leading cause of death in the U.S., and emerging evidence suggests that environmental toxicants such as cadmium may contribute to cerebrovascular risk. This study investigates the association between cadmium exposure and cerebrovascular mortality in a nationally representative sample of U.S. adults.

Methods

We analyzed data from adults aged ≥40 years in the National Health and Nutrition Examination Survey (NHANES) 1999–2016 cycles, with mortality follow-up through 2019. Blood cadmium was measured in 23,455 participants, and urinary cadmium was measured in 8929 participants. Cerebrovascular deaths were identified through linkage with the National Death Index. Survey-weighted Cox proportional hazards models evaluated associations between cadmium concentrations and cerebrovascular mortality.

Results

Over a mean follow-up of 10.2 years, 247 cerebrovascular deaths were observed. Each interquartile range increase in blood cadmium (0.40 µg/L) was associated with a 23 % higher risk of cerebrovascular mortality (HR = 1.23, 95 % CI: 1.04–1.46). Urinary cadmium was also associated with higher cerebrovascular mortality, although marginally significant (HR = 1.36 per doubling, 95 % CI: 0.99–1.87). Associations appeared stronger among former and current smokers, though interaction terms were not statistically significant.

Conclusions

Cadmium exposure is associated with increased cerebrovascular mortality in the U.S. population. These findings support cadmium as a modifiable environmental risk factor and underscore the need for public health interventions to reduce exposure through tobacco control, dietary regulations, and environmental policy.

背景在美国，脑血管疾病是导致死亡的主要原因之一，而且越来越多的证据表明，镉等环境毒物可能会增加脑血管风险。本研究调查了镉暴露与脑血管死亡率之间的关系，在美国成年人的全国代表性样本。方法分析1999-2016年国家健康与营养调查（NHANES）周期中年龄≥40岁的成年人的数据，并随访至2019年的死亡率。在23,455名参与者中测量了血镉，在8929名参与者中测量了尿镉。脑血管死亡是通过与国家死亡指数的联系来确定的。调查加权Cox比例风险模型评估了镉浓度与脑血管死亡率之间的关系。结果平均随访10.2年，共发生247例脑血管死亡。血镉浓度每增加四分位数（0.40µg/L），脑血管死亡风险增加23% （HR = 1.23, 95% CI: 1.04-1.46）。尿镉也与较高的脑血管死亡率相关，尽管有边际意义（HR = 1.36 / 2倍，95% CI: 0.99-1.87）。尽管相互作用项在统计上不显著，但在曾经和现在的吸烟者之间的关联似乎更强。结论：在美国人群中，镉暴露与脑血管死亡率增加有关。这些发现支持镉是一种可改变的环境风险因素，并强调需要通过烟草控制、饮食法规和环境政策进行公共卫生干预，以减少镉的暴露。

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引用次数: 0

Exposure to organophosphate esters (OPEs) of children (1-12y) in Guangxi, China: Predictors evaluation by machine learning 中国广西儿童（1-12岁）暴露于有机磷酸酯（OPEs）：机器学习预测评估

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1016/j.heha.2025.100159

Na Li , Ting Fan Leung , Linwei Tian , Huachang Hong , Wen-Jing Deng

Organophosphate esters (OPEs), widely employed as flame-retardants and plasticizers, have been linked to adverse health outcomes in children. This study evaluated the predictors of OPE exposure in children aged 1 to 12 years in Guangxi, China. Eleven OPEs were detected in a cohort of 84 children and their parents’ urine, with geometric mean (GM) levels ranging from 0.11 ng/g_crea (tri-n-propyl phosphate, TPP) to 25.93 ng/g_crea (tris(2,3-dichloropropyl) phosphate, TDCPP) in children, and from 0.04 ng/g_crea (triphenyl phosphate, TPHP) to 18.71 ng/g_crea (TDCPP) in parents. These findings are consistent with values reported in several large-scale national urinary biomonitoring studies on OPEs. Significant positive correlations among most target OPEs and no significant gender and age differences in children’s urine were found. The eXtreme Gradient Boosting (XGBoost) coupled with Shapley Additive explanations (SHAP), was employed to analyse the importance of 93 variables from the questionnaire and interpret the levels of OPEs in children’s urine. Models for six OPEs were constructed, revealing that daily use of fans affected the levels of five OPEs. Additionally, egg consumption and the number of family members were associated with higher levels of TPP/TCEP, and CDP/TEHP, respectively. There is a need to conduct more precise quantitative assessments of OPE exposure routes.

广泛用作阻燃剂和增塑剂的有机磷酸酯（OPEs）与儿童的不良健康结果有关。本研究评估了中国广西1至12岁儿童暴露于OPE的预测因素。在84名儿童及其父母的尿液中检测到11种OPEs，儿童的几何平均（GM）水平从0.11 ng/gcrea（三正丙基磷酸，TPP）到25.93 ng/gcrea（三（2,3-二氯丙基）磷酸，TDCPP）到0.04 ng/gcrea（三苯基磷酸，TPHP）到18.71 ng/gcrea（三苯基磷酸，TDCPP）。这些发现与几项大规模国家泌尿系统生物监测研究报告的结果一致。大多数目标OPEs之间存在显著的正相关，儿童尿液中没有显著的性别和年龄差异。采用极限梯度提升法（XGBoost）结合Shapley加性解释法（SHAP）分析问卷中93个变量的重要性，并解释儿童尿液中OPEs的水平。构建了6个OPEs的模型，揭示了风机的日常使用影响了5个OPEs的水平。此外，鸡蛋摄入量和家庭成员数量分别与较高水平的TPP/TCEP和CDP/TEHP有关。有必要对接触外伤性脑炎的途径进行更精确的定量评估。

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引用次数: 0

Blood cadmium and lead concentrations in association with homocysteine and all-cause and cardiovascular mortality 血镉和铅浓度与同型半胱氨酸、全因死亡率和心血管死亡率的关系

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.heha.2025.100148

Shaohui Liu , Ziqi Zeng , Quanhong Chen , Anan Zhou , Yunan Xu , Hao Chen , Yunfeng Zou

Cadmium and lead exposure are reported to associate with elevated plasma homocysteine concentrations. However, whether homocysteine plays a role in the associations of cadmium and lead with all-cause and cardiovascular mortality is unclear. We conducted a cohort study using data from 6456 participants in the National Health and Nutrition Examination Survey (NHANES) (2003–2006). Cox regression models and restricted cubic splines (RCS) were used to examine the associations between cadmium, lead, and homocysteine and all-cause and cardiovascular mortality. Mediation analysis was conducted to evaluate the indirect effect of homocysteine in the associations between cadmium, lead and all-cause and cardiovascular mortality. During a median of 14.33 years of follow-up, 1642 (25.43 %) all-cause deaths and 575 (8.91 %) cardiovascular deaths were observed. When compared with the first quartile, cadmium, lead, and homocysteine levels in the fourth quartile were associated with increased all-cause mortality risk [hazard ratios (HRs) with 95 % confidence interval (CI) 1.91 (1.60, 2.29), 1.38 (1.16, 1.64), and 1.74 (1.42, 2.14), respectively] and cardiovascular mortality [1.85 (1.37, 2.50), 1.55 (1.15, 2.09), 1.67 (1.17, 2.37), respectively]. RCS analysis suggested nonlinear associations of cadmium, lead, and homocysteine with all-cause mortality, nonlinear relationships between cadmium and cardiovascular mortality, and linear associations between lead, homocysteine and cardiovascular mortality. Changes in homocysteine levels accounted for approximately 4.11 % and 5.81 % of the observed associations between cadmium exposure and all-cause and cardiovascular mortality, respectively. Similar observations were made for homocysteine on the associations of lead exposure and all-cause (11.05 %) and cardiovascular (7.69 %) mortality. Furthermore, lead concentrations modified the associations of cadmium and homocysteine with cardiovascular and all-cause mortality. Our findings suggested that plasma homocysteine was associated with the observed relationships between cadmium and lead exposure and increased all-cause and cardiovascular mortality, potentially reflecting underlying pathways relevant to heavy metal-related cardiovascular risk.

据报道，镉和铅暴露与血浆同型半胱氨酸浓度升高有关。然而，同型半胱氨酸是否在镉和铅与全因死亡率和心血管死亡率的关联中起作用尚不清楚。我们使用2003-2006年国家健康与营养检查调查（NHANES）的6456名参与者的数据进行了一项队列研究。使用Cox回归模型和限制性三次样条（RCS）来检查镉、铅和同型半胱氨酸与全因死亡率和心血管死亡率之间的关系。进行了中介分析，以评估同型半胱氨酸在镉、铅与全因死亡率和心血管死亡率之间的间接影响。在中位14.33年的随访期间，观察到1642例（25.43%）全因死亡和575例（8.91%）心血管死亡。与第一个四分位数相比，第四个四分位数的镉、铅和同型半胱氨酸水平与全因死亡风险增加相关[95%可信区间（CI）分别为1.91（1.60,2.29）、1.38（1.16,1.64）和1.74(1.42,2.14)]和心血管死亡率[分别为1.85（1.37,2.50）、1.55（1.15,2.09）、1.67(1.17,2.37)]。RCS分析表明，镉、铅和同型半胱氨酸与全因死亡率呈非线性关系，镉与心血管死亡率呈非线性关系，铅、同型半胱氨酸与心血管死亡率呈线性关系。在观察到的镉暴露与全因死亡率和心血管死亡率之间的关联中，同型半胱氨酸水平的变化分别占约4.11%和5.81%。同型半胱氨酸对铅暴露与全因死亡率（11.05%）和心血管死亡率（7.69%）之间的关系也进行了类似的观察。此外，铅浓度改变了镉和同型半胱氨酸与心血管和全因死亡率的关系。我们的研究结果表明，血浆同型半胱氨酸与观察到的镉和铅暴露、全因死亡率和心血管死亡率增加之间的关系有关，可能反映了与重金属相关的心血管风险相关的潜在途径。

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引用次数: 0

Air pollution mixtures and stillbirth: k-means cluster analysis 空气污染混合物与死产：k均值聚类分析

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.heha.2025.100153

Naomi O. Riches , Ramkiran Gouripeddi , Robert M. Silver , Julio C. Facelli

Background

Preventing stillbirths starts with identifying modifiable risk factors, such as air pollution (AP). Most research has focused on individual components of AP (e.g. PM_2.5) to assess the linear relationship between air pollutant concentration and stillbirth, with mixed results. However, the air we breathe is a mixture of gases and particles. The purpose of this study was to assess how mixtures of criteria air pollutants are associated with stillbirth in the United States.

Materials and Methods

Air pollution data from the US Environmental Protection Agency and individual US birth and fetal death data from the CDC National Vital Statistics System were used. Air pollutant exposures were clustered using k-means clustering. A categorical variable linking each patient to one of these clusters was used in a regression analysis.

Results

Four AP clusters were identified through k-means. Exposure to air pollution mixtures included in Clusters 1, 2, and 4 during pregnancy was associated with a 40%, 13%, and 43% increase in the odds of stillbirth, compared to Cluster 3 (reference), (OR = 1.40, 95% CI: 1.36-1.44, p<0.001; OR = 1.13, 95% CI: 1.09-1.16, p<0.001; OR = 1.43, 95% CI: 1.38-1.49, p<0.001), respectively.

Discussion

The air pollution cluster associated with the greatest odds of stillbirth was high in PM_2.5 and SO₂, which may indicate industrial sources. To our knowledge, this is the first study to assess the impact of air pollution mixtures on stillbirth using k-means clustering. This method can be used to identify non-linear relationships between mixtures of air pollution and a health outcome.

预防死产始于确定可改变的风险因素，如空气污染（AP）。大多数研究都集中在AP的单个成分（例如PM2.5）上，以评估空气污染物浓度与死胎之间的线性关系，结果好坏参半。然而，我们呼吸的空气是气体和颗粒的混合物。本研究的目的是评估美国标准空气污染物的混合物与死产的关系。材料和方法使用美国环境保护署的空气污染数据和美国疾病控制与预防中心国家生命统计系统的美国出生和胎儿死亡数据。采用k-均值聚类对空气污染物暴露进行聚类。在回归分析中使用了将每个患者与其中一个集群联系起来的分类变量。结果通过k-means鉴定出4个AP聚类。与聚类3（参考文献）相比，妊娠期间暴露于聚类1、2和4中的空气污染混合物与死产几率分别增加40%、13%和43%相关（OR = 1.40, 95% CI: 1.36-1.44, p<0.001; OR = 1.13, 95% CI: 1.09-1.16, p<0.001; OR = 1.43, 95% CI: 1.38-1.49, p<0.001）。与死产几率最高相关的空气污染集群PM2.5和SO2含量较高，这可能表明工业来源。据我们所知，这是第一个使用k均值聚类来评估空气污染混合物对死胎影响的研究。这种方法可用于确定空气污染混合物与健康结果之间的非线性关系。

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引用次数: 0

Effects of occupational exposure factors interacting with NLRP3 gene polymorphisms on mild cognitive impairment: A cross-sectional study of workers in an aluminum electrolysis production environment 职业暴露因素与NLRP3基因多态性相互作用对轻度认知障碍的影响：铝电解生产环境中工人的横断面研究

IF 2.7

Hygiene and environmental health advances

Pub Date : 2025-12-01 Epub Date: 2025-08-26 DOI: 10.1016/j.heha.2025.100144

Youxing Li , Yaqin Pang , Wenxue Li , Dongshun Chen , Caiping Zhang , Yufang Cen , Junhong Wei , Rongqing Xiao , Wenlian Rao , Yinxia Lin , Ahmad Razali Ishak , Mohd Shukri Bin Mohd Aris , Guangzi Qi

Mild cognitive impairment (MCI) is an early stage of Alzheimer's disease and is the result of interactions between environmental and genetic factors. However, their impact on aluminum workers is not yet clear. This study aimed to explore the interaction between occupational exposure and NLRP3 gene polymorphisms on the odds of MCI among aluminum production workers. We assessed the cognitive function of 478 workers in a factory in Guangxi, China, and identified two main occupational exposure factors: principal component 1 (PC1: noise, high temperature, carbon monoxide, sulfur dioxide, nitrogen oxides) and principal component 2 (PC2: aluminum oxide dust, magnetic field, fluoride, manganese dioxide). Genotyping of polymorphisms in the NLRP3 gene (rs10754558, rs10925027, rs3806265, rs4612666) was performed. The results of the analysis showed that high PC2 exposure significantly increased the odds of MCI [OR (95 % CI): 1.99 (1.36, 2.91)], and the rs10754558 G/C genotype was independently associated with MCI [OR (95 % CI): 1.56 (1.05, 2.33)]. PC2 interacted with rs3806265 C/T [OR (95 % CI):2.13 (1.16, 3.92)] and rs4612666 C/T [OR (95 % CI): 2.84 (1.19,6.81)], further increasing the odds of MCI. These findings suggest that alumina dust, magnetic fields, fluoride, and manganese dioxide are the main occupational hazards factors for MCI. rs10754558 G/C is an independent susceptibility genotype for MCI, while rs3806265 C/T and rs4612666 C/T are environmental susceptibility genotypes for MCI. This study emphasizes that reducing occupational exposure and screening for susceptibility genes can provide a basis for targeted interventions to reduce the odds of MCI in this population.

轻度认知障碍（MCI）是阿尔茨海默病的早期阶段，是环境和遗传因素相互作用的结果。然而，它们对铝业工人的影响尚不清楚。本研究旨在探讨职业暴露与NLRP3基因多态性对铝生产工人MCI患病几率的相互作用。我们评估了中国广西某工厂478名工人的认知功能，并确定了两个主要的职业暴露因素：主成分1 （PC1：噪音、高温、一氧化碳、二氧化硫、氮氧化物）和主成分2 （PC2：氧化铝粉尘、磁场、氟化物、二氧化锰）。对NLRP3基因（rs10754558、rs10925027、rs3806265、rs4612666）的多态性进行基因分型。分析结果显示，高PC2暴露显著增加MCI的发生几率[OR (95% CI): 1.99 (1.36, 2.91)]， rs10754558 G/C基因型与MCI独立相关[OR (95% CI): 1.56(1.05, 2.33)]。PC2与rs3806265 C/T [OR (95% CI):2.13(1.16, 3.92)]和rs4612666 C/T [OR (95% CI): 2.84(1.19,6.81)]相互作用，进一步增加MCI的发生几率。综上所述，氧化铝粉尘、磁场、氟化物和二氧化锰是MCI的主要职业危害因素。rs10754558 G/C为MCI的独立易感基因型，rs3806265 C/T和rs4612666 C/T为MCI的环境易感基因型。本研究强调，减少职业暴露和筛查易感基因可以为有针对性的干预提供基础，以降低这一人群MCI的发生率。

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