Pub Date : 2023-10-16DOI: 10.1097/jd9.0000000000000350
Rong Tao, Zhe Wan, Ruo-Yu Li, Ruo-Jun Wang
Objective: Current theories highlight the role of the microbiome in the pathogenesis of psoriasis. Additionally, abnormal metabolism can alter disease processes in terms of occurrence, progression, and prognosis. Therefore, an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for psoriasis. Methods: We recruited 22 patients with psoriasis and 22 age- and sex-matched healthy controls. Skin swabs were collected from the participants’ scalps. All samples underwent amplicon sequencing of the ITS1 and V3V4 16S rRNA regions and metabolome analysis. Results: The psoriatic lesions were characterized by higher bacterial diversity, significantly higher abundances of Corynebacterium and Staphylococcus , and a lower abundance of Cutibacterium compared with healthy controls. However, no significant alterations in the fungal diversity or fungal taxonomies were detected. Metabolome analysis revealed that prostaglandin-related metabolites, nucleotides, and cysteine- and methionine-related metabolites were significantly enriched in patients with psoriasis, and these metabolites were positively correlated with the disease-associated bacteria Staphylococcus and Corynebacterium . Conclusions: We demonstrated significant alterations in the skin microbiome and metabolome in patients with psoriasis compared with healthy controls.
{"title":"Integrated skin microbiome and metabolome analyses reveal altered bacterial community composition and metabolites in psoriasis","authors":"Rong Tao, Zhe Wan, Ruo-Yu Li, Ruo-Jun Wang","doi":"10.1097/jd9.0000000000000350","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000350","url":null,"abstract":"Objective: Current theories highlight the role of the microbiome in the pathogenesis of psoriasis. Additionally, abnormal metabolism can alter disease processes in terms of occurrence, progression, and prognosis. Therefore, an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for psoriasis. Methods: We recruited 22 patients with psoriasis and 22 age- and sex-matched healthy controls. Skin swabs were collected from the participants’ scalps. All samples underwent amplicon sequencing of the ITS1 and V3V4 16S rRNA regions and metabolome analysis. Results: The psoriatic lesions were characterized by higher bacterial diversity, significantly higher abundances of Corynebacterium and Staphylococcus , and a lower abundance of Cutibacterium compared with healthy controls. However, no significant alterations in the fungal diversity or fungal taxonomies were detected. Metabolome analysis revealed that prostaglandin-related metabolites, nucleotides, and cysteine- and methionine-related metabolites were significantly enriched in patients with psoriasis, and these metabolites were positively correlated with the disease-associated bacteria Staphylococcus and Corynebacterium . Conclusions: We demonstrated significant alterations in the skin microbiome and metabolome in patients with psoriasis compared with healthy controls.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.1097/jd9.0000000000000348
Shivali Devjani, Ogechi Ezemma, Kristen J. Kelley, Maryanne Makredes Senna
Devjani, Shivali1; Ezemma, Ogechi1; Kelley, Kristen J.1; Senna, Maryanne Makredes1,2 Author Information
Devjani Shivali1;Ezemma Ogechi1;你有多久?你是媒体吗
{"title":"Platelet-Rich Plasma for Androgenetic Alopecia: What the Dermatologist Needs to Know","authors":"Shivali Devjani, Ogechi Ezemma, Kristen J. Kelley, Maryanne Makredes Senna","doi":"10.1097/jd9.0000000000000348","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000348","url":null,"abstract":"Devjani, Shivali1; Ezemma, Ogechi1; Kelley, Kristen J.1; Senna, Maryanne Makredes1,2 Author Information","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136058030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Climatic Factors on Varicella-Zoster Viral Infection","authors":"Sarah-Jane Dempsey, Louise K. Andersen, Sarah J. Coates, Mark D.P. Davis","doi":"10.1097/jd9.0000000000000347","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000347","url":null,"abstract":"Dempsey, Sarah-Jane; Andersen, Louise K. MD; Coates, Sarah J. MD; Davis, Mark D.P. MD Author Information","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136313170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitiligo is an autoimmune disorder caused by the destruction of melanocytes in various body regions. Numerous diseases may accompany vitiligo. The prevalence of vitiligo varies among geographical regions and shows no relation to sex or age. However, vitiligo most commonly affects people aged 10 to 30 years. The clinical symptoms of vitiligo include irregular patches on the skin and various diseases associated with this disorder. The present review focuses on the clinical effects and risk factors of vitiligo-associated conditions and the current therapeutics for treating vitiligo. This systematic review was performed based on the PRISMA guidelines and articles published from 2000 to 2023 in several electronic databases (Web of Science, PubMed, PsycINFO, and others). The most clinically significant diseases associated with vitiligo are alopecia areata, autoimmune thyroid disease, Addison's disease, and type 1 diabetes mellitus. No targeted population is specifically prone to vitiligo; it does not affect any particular race or sex. Hence, awareness of the diseases associated with vitiligo is necessary to control them through various medical and surgical treatments with the proper facilities.
白癜风是一种自身免疫性疾病，由身体各个部位的黑色素细胞破坏引起。许多疾病可能伴随白癜风。白癜风的患病率因地理区域而异，与性别或年龄无关。然而，白癜风最常见于10至30岁的人群。白癜风的临床症状包括皮肤上不规则的斑块和与此疾病相关的各种疾病。现就白癜风相关疾病的临床疗效、危险因素及目前治疗白癜风的方法作一综述。本系统综述基于PRISMA指南和2000年至2023年在几个电子数据库(Web of Science、PubMed、PsycINFO等)中发表的文章。与白癜风相关的最重要的临床疾病是斑秃、自身免疫性甲状腺疾病、Addison病和1型糖尿病。没有目标人群特别容易患白癜风;它不影响任何特定的种族或性别。因此，意识到与白癜风相关的疾病是必要的，通过适当的医疗和手术治疗来控制它们。
{"title":"An extensive review of vitiligo-associated conditions","authors":"Madhavi Premkumar, Iyshwarya Bhaskar Kalarani, Vajagathali Mohammed, Ramakrishnan Veerabathiran","doi":"10.1097/jd9.0000000000000346","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000346","url":null,"abstract":"Vitiligo is an autoimmune disorder caused by the destruction of melanocytes in various body regions. Numerous diseases may accompany vitiligo. The prevalence of vitiligo varies among geographical regions and shows no relation to sex or age. However, vitiligo most commonly affects people aged 10 to 30 years. The clinical symptoms of vitiligo include irregular patches on the skin and various diseases associated with this disorder. The present review focuses on the clinical effects and risk factors of vitiligo-associated conditions and the current therapeutics for treating vitiligo. This systematic review was performed based on the PRISMA guidelines and articles published from 2000 to 2023 in several electronic databases (Web of Science, PubMed, PsycINFO, and others). The most clinically significant diseases associated with vitiligo are alopecia areata, autoimmune thyroid disease, Addison's disease, and type 1 diabetes mellitus. No targeted population is specifically prone to vitiligo; it does not affect any particular race or sex. Hence, awareness of the diseases associated with vitiligo is necessary to control them through various medical and surgical treatments with the proper facilities.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135152885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2023-01-10DOI: 10.1097/jd9.0000000000000286
Alexa J Cohen, Laura K Gleason, Safiyyah A Bhatti, Neda Nikbakht
Introduction: Neutrophilic panniculitis (NP) is a rare subtype of neutrophilic dermatosis, a group of neutrophil-rich inflammatory skin disorders that can present in association with myeloid neoplasms. NP is defined by the presence of a neutrophilic infiltrate in the fat lobules of the subcutis in the absence of either infection or vasculitis. We herein describe a 65-year-old woman with a recent diagnosis of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome (MDS/MPN) who abruptly developed painful, pruritic nodules consistent with NP.
Case presentation: A 65-year-old woman with MDS/MPN presented for evaluation of painful and pruritic nodules on her upper and lower extremities. A biopsy revealed a lobular neutrophilic infiltrate in the subcutis without evidence of microorganisms or vasculitis. The patient was diagnosed with NP and treated with oral prednisone. Within 1 month of treatment, she reported complete resolution of the nodules.
Discussion: Similar to other neutrophilic dermatoses, NP may arise in association with hematologic malignancies of myeloid origin, such as MDS/MPN. A literature review revealed that most cases of NP associated with MDS occur after the onset of MDS and respond to systemic corticosteroids, not antibiotics. Infection should be ruled out before initiating treatment with systemic steroids.
Conclusion: Although the mechanism is still unknown, it is important for clinicians to be aware that NP is associated with MDS; thus, hematological malignancies should be investigated upon diagnosis of NP. Once diagnosed, NP is easily treated and has an excellent response to systemic corticosteroids.
{"title":"Neutrophilic panniculitis associated with myelodysplastic syndrome/myeloproliferative neoplasm: a case report and literature review.","authors":"Alexa J Cohen, Laura K Gleason, Safiyyah A Bhatti, Neda Nikbakht","doi":"10.1097/jd9.0000000000000286","DOIUrl":"10.1097/jd9.0000000000000286","url":null,"abstract":"<p><strong>Introduction: </strong>Neutrophilic panniculitis (NP) is a rare subtype of neutrophilic dermatosis, a group of neutrophil-rich inflammatory skin disorders that can present in association with myeloid neoplasms. NP is defined by the presence of a neutrophilic infiltrate in the fat lobules of the subcutis in the absence of either infection or vasculitis. We herein describe a 65-year-old woman with a recent diagnosis of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome (MDS/MPN) who abruptly developed painful, pruritic nodules consistent with NP.</p><p><strong>Case presentation: </strong>A 65-year-old woman with MDS/MPN presented for evaluation of painful and pruritic nodules on her upper and lower extremities. A biopsy revealed a lobular neutrophilic infiltrate in the subcutis without evidence of microorganisms or vasculitis. The patient was diagnosed with NP and treated with oral prednisone. Within 1 month of treatment, she reported complete resolution of the nodules.</p><p><strong>Discussion: </strong>Similar to other neutrophilic dermatoses, NP may arise in association with hematologic malignancies of myeloid origin, such as MDS/MPN. A literature review revealed that most cases of NP associated with MDS occur after the onset of MDS and respond to systemic corticosteroids, not antibiotics. Infection should be ruled out before initiating treatment with systemic steroids.</p><p><strong>Conclusion: </strong>Although the mechanism is still unknown, it is important for clinicians to be aware that NP is associated with MDS; thus, hematological malignancies should be investigated upon diagnosis of NP. Once diagnosed, NP is easily treated and has an excellent response to systemic corticosteroids.</p>","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1097/jd9.0000000000000322
{"title":"Correlation of Whole Blood Zinc Levels, CD4 Cell Count, Disease Stage, and Dermatologic Manifestations Among HIV Patients: A Single Center Experience in Philippines: Erratum","authors":"","doi":"10.1097/jd9.0000000000000322","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000322","url":null,"abstract":"","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To describe the epidemiological characteristics of leprosy in China in 2021 and provide essential information for future national leprosy control and prevention strategies. Methods: We collected epidemiological data of leprosy from 31 provinces, autonomous regions, and municipalities of China (except for Hong Kong, Macao, and Taiwan) provided by the Leprosy Management Information System. We performed a comparative analysis of the epidemiological features of patients with leprosy including age, sex, geographical distribution, and grade of disability. Results: In total, 374 newly detected leprosy cases were reported nationwide in China in 2021, giving an incidence rate of 0.27 per million population, which represented a decrease of 7.9% compared with 2020. Among the population with leprosy in 2021 that comprised 238 males (63.6%) and 136 females (36.4%), 1.9% (7/374) were children younger than 15 years, 92.8% (347/374) had multibacillary leprosy, and 18.2% (68/374) had grade 2 disability. More than half of the new leprosy cases (54.8%, 205/374) were distributed in southwest China. There were 33 relapsed leprosy cases reported in 2021. By the end of 2021, there were 1,897 registered leprosy cases reported nationwide, giving a prevalence rate of 1.35 per million population. Conclusion: The leprosy epidemic in China shows a downward trend in terms of the prevalence and incidence rates. However, the high prevalence of leprosy in southwest China is still a matter of concern.
{"title":"Epidemiology of leprosy in China, 2021: an update","authors":"Ying Shi, Pei-Wen Sun, Le Wang, Hong-Sheng Wang, Mei-Wen Yu, Heng Gu","doi":"10.1097/jd9.0000000000000344","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000344","url":null,"abstract":"Objective: To describe the epidemiological characteristics of leprosy in China in 2021 and provide essential information for future national leprosy control and prevention strategies. Methods: We collected epidemiological data of leprosy from 31 provinces, autonomous regions, and municipalities of China (except for Hong Kong, Macao, and Taiwan) provided by the Leprosy Management Information System. We performed a comparative analysis of the epidemiological features of patients with leprosy including age, sex, geographical distribution, and grade of disability. Results: In total, 374 newly detected leprosy cases were reported nationwide in China in 2021, giving an incidence rate of 0.27 per million population, which represented a decrease of 7.9% compared with 2020. Among the population with leprosy in 2021 that comprised 238 males (63.6%) and 136 females (36.4%), 1.9% (7/374) were children younger than 15 years, 92.8% (347/374) had multibacillary leprosy, and 18.2% (68/374) had grade 2 disability. More than half of the new leprosy cases (54.8%, 205/374) were distributed in southwest China. There were 33 relapsed leprosy cases reported in 2021. By the end of 2021, there were 1,897 registered leprosy cases reported nationwide, giving a prevalence rate of 1.35 per million population. Conclusion: The leprosy epidemic in China shows a downward trend in terms of the prevalence and incidence rates. However, the high prevalence of leprosy in southwest China is still a matter of concern.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135990885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.1097/jd9.0000000000000343
Jie Liu, Xuan Wang, Xiao-Ling Yu, Zhi-Miao Lin, Li-Yan Yuan, Bin Yang
Objective: Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health. While biologics have been shown to be effective in treating psoriatic lesions, thus improving QoL, real-life data regarding such effects remain scant. We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis. Methods: From March to May 2022, patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University. Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics. Psoriasis severity, QoL, and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), 36-Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS). A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators. Results: Among the 78 enrolled patients, the ranges of pretreatment scores were 4.6–46.8 for the PASI, 1–30 for the DLQI, 31.5–100 for the physical component score (PCS) of the SF-36, 16.6–100 for the mental component score (MCS) of the SF-36, 0–15 for the HADS-A, and 0–17 for the HADS-D. After 8 weeks of biologics treatment, 98.7% (77/78) of patients had obtained PASI 75. All assessed scores changed over time (GEE, P < 0.05). Moreover, there were group-by-time interaction effects for the DLQI score (GEE, P = 0.023) and PCS (GEE, P = 0.029). The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values. Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression. Conclusion: Biologics are not only effective in the treatment of skin lesions, but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.
目的:银屑病是一种严重影响患者生活质量和心理健康的慢性炎性全身性疾病。虽然生物制剂已被证明对治疗银屑病病变有效，从而改善生活质量，但关于这种效果的实际数据仍然很少。我们进行了一项重复的横断面调查，以评估8周生物制剂治疗对中重度斑块型银屑病患者生活质量和心理健康状况的影响。方法:于2022年3月至5月在南方医科大学皮肤病医院门诊招募中重度斑块型银屑病患者，并给予生物制剂治疗。分别在治疗前、生物制剂治疗4周和8周后进行评估。采用银屑病面积及严重程度指数(PASI)、皮肤病生活质量指数(DLQI)、36项简短健康调查(SF-36)和医院焦虑抑郁量表(HADS)评估银屑病严重程度、生活质量和心理健康状况。使用多元广义估计方程(GEE)分析来解释重复测量，并确定治疗时间和生物制剂类型对相关指标的影响。结果:78例入组患者中，PASI预处理评分范围为4.6 ~ 46.8分，DLQI预处理评分范围为1 ~ 30分，SF-36预处理评分范围为31.5 ~ 100分，SF-36预处理评分范围为16.6 ~ 100分，HADS-A预处理评分范围为0 ~ 15分，HADS-D预处理评分范围为0 ~ 17分。经过8周的生物制剂治疗，98.7%(77/78)的患者达到PASI 75。所有评估分数都随时间变化(GEE, P <0.05)。此外，DLQI评分(GEE, P = 0.023)和PCS (GEE, P = 0.029)存在分组-时间交互效应。与预处理值相比，HADS-A和HADS-D评分在第8周均下降。相关分析显示，DLQI得分越高，生活质量水平越低，焦虑或抑郁水平越高。结论:生物制剂不仅能有效治疗皮肤病变，而且对银屑病患者的生活质量和心理健康也有有益的影响，这是本研究短期评估的结果。
{"title":"Effects of three different biologics on mental health and health-related quality of life in patients with psoriasis: a repeated cross-sectional survey of Chinese patients","authors":"Jie Liu, Xuan Wang, Xiao-Ling Yu, Zhi-Miao Lin, Li-Yan Yuan, Bin Yang","doi":"10.1097/jd9.0000000000000343","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000343","url":null,"abstract":"Objective: Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health. While biologics have been shown to be effective in treating psoriatic lesions, thus improving QoL, real-life data regarding such effects remain scant. We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis. Methods: From March to May 2022, patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University. Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics. Psoriasis severity, QoL, and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), 36-Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS). A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators. Results: Among the 78 enrolled patients, the ranges of pretreatment scores were 4.6–46.8 for the PASI, 1–30 for the DLQI, 31.5–100 for the physical component score (PCS) of the SF-36, 16.6–100 for the mental component score (MCS) of the SF-36, 0–15 for the HADS-A, and 0–17 for the HADS-D. After 8 weeks of biologics treatment, 98.7% (77/78) of patients had obtained PASI 75. All assessed scores changed over time (GEE, P < 0.05). Moreover, there were group-by-time interaction effects for the DLQI score (GEE, P = 0.023) and PCS (GEE, P = 0.029). The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values. Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression. Conclusion: Biologics are not only effective in the treatment of skin lesions, but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136239510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.1097/jd9.0000000000000342
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
{"title":"Mental Stress Affects the Occurrence and Development of Psoriasis Through Neuroendocrine-Immune Regulation: A Narrative Review","authors":"","doi":"10.1097/jd9.0000000000000342","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000342","url":null,"abstract":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135715939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1097/JD9.0000000000000184
[This corrects the article DOI: 10.1097/JD9.0000000000000170.].
[更正文章DOI: 10.1097/JD9.0000000000000170.]。
{"title":"Erratum: Genetic Predisposition to Numerous Large Ulcerating Basal Cell Carcinomas and Response to Immune Therapy: Erratum.","authors":"","doi":"10.1097/JD9.0000000000000184","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000184","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/JD9.0000000000000170.].</p>","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/57/jd9-6-106.PMC10309099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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