Pub Date : 2024-01-30DOI: 10.1097/jd9.0000000000000369
Chun-Yu Han, Xin Li, Ya-Qi Cao, Yi Zhang, Hong-Min Han, Jing Li, Xin Lyu, Jian-Wen Han
{"title":"Genetic analysis and evaluation of 2% cholesterol / 2% simvastatin cream in a family with CHILD syndrome","authors":"Chun-Yu Han, Xin Li, Ya-Qi Cao, Yi Zhang, Hong-Min Han, Jing Li, Xin Lyu, Jian-Wen Han","doi":"10.1097/jd9.0000000000000369","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000369","url":null,"abstract":"","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"64 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140482533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30DOI: 10.1097/jd9.0000000000000370
Meilin Ding, Hongyang Li, Jingjing Xu, Kun Ren, Wei Zhang
Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that acts as an extracellular and intracellular messenger in a variety of biological activities, many of which are mediated by binding to S1P-specific G protein-coupled receptors. S1P receptors can affect cell fate by mediating cell differentiation, proliferation, and apoptosis. S1P mainly plays an immunomodulatory role in vivo. In recent years, increasing numbers of studies have shown that S1P is involved in the occurrence and development of immune-related skin diseases by regulating keratinocyte differentiation, proliferation, and apoptosis; lymphocyte migration; and angiogenesis. This review explores the metabolism and signal transduction mechanism of S1P, focusing on research advancements in the immune regulation function of S1P and its impact on immune-related skin diseases. The aim is to provide insights that can contribute to the research and application of S1P in immune-related skin diseases.
{"title":"Research advancements in the immunomodulating effect of sphingosine-1-phosphate in skin diseases","authors":"Meilin Ding, Hongyang Li, Jingjing Xu, Kun Ren, Wei Zhang","doi":"10.1097/jd9.0000000000000370","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000370","url":null,"abstract":"Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that acts as an extracellular and intracellular messenger in a variety of biological activities, many of which are mediated by binding to S1P-specific G protein-coupled receptors. S1P receptors can affect cell fate by mediating cell differentiation, proliferation, and apoptosis. S1P mainly plays an immunomodulatory role in vivo. In recent years, increasing numbers of studies have shown that S1P is involved in the occurrence and development of immune-related skin diseases by regulating keratinocyte differentiation, proliferation, and apoptosis; lymphocyte migration; and angiogenesis. This review explores the metabolism and signal transduction mechanism of S1P, focusing on research advancements in the immune regulation function of S1P and its impact on immune-related skin diseases. The aim is to provide insights that can contribute to the research and application of S1P in immune-related skin diseases.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"58 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-23DOI: 10.1097/jd9.0000000000000368
Quang Minh Nguyen, Mai Le Thi, Hieu Duong Phuc, Ha Vu Thai, Doanh Le Huu
Botulinum toxin type A is frequently used to treat crow’s feet lines. However, the optimal dose and injection sites are still controversial. The objective of this study was to compare the efficacy of different botulinum toxin type A injection patterns for the treatment of crow’s feet. This single-center, retrospective, cohort study was conducted at the National Hospital of Dermatology. Sixty patients with crow’s feet were recruited and randomly assigned in a 1:1 ratio to receive botulinum toxin type A using either a three-point or a four-point intramuscular injection technique. The treatment efficacy was assessed based on the changes in the Crow’s Feet Grading Scale score at 1, 4 and 16 weeks after treatment. After treatment, the average Crow’s Feet Grading Scale score was significantly decreased compared with the pretreatment score at all timepoints (1, 4, and 16 weeks) in both states (dynamic and static). The average subjective patient-rated satisfaction scores after treatment were significantly higher in the four-point injection group than the three-point injection group (P=0.028). The adverse events were post-injection bruising in three patients and a feeling of eyelid tightness in three patients. Botulinum toxin type A injection is an effective treatment for crow’s feet. Adding a fourth injection maintains the same therapeutic effect and does not increase adverse effects. Patients with lower-fan crow’s feet patterns may benefit more from four-point injection therapy. However, the present findings require confirmation in studies with larger sample sizes, longer follow-up times, and different botulinum toxin type A doses.
A 型肉毒杆菌毒素常用于治疗鱼尾纹。然而，最佳剂量和注射部位仍存在争议。本研究旨在比较不同的 A 型肉毒毒素注射模式对治疗鱼尾纹的疗效。 这项单中心、回顾性、队列研究在国立皮肤病医院进行。研究人员招募了 60 名鱼尾纹患者，并按 1:1 的比例随机分配他们接受三点式或四点式肌肉注射 A 型肉毒毒素。疗效根据治疗后 1 周、4 周和 16 周的鱼尾纹评分量表得分变化进行评估。 治疗后，与治疗前相比，在所有时间点（1、4 和 16 周），两种状态（动态和静态）的鱼尾纹评分量表平均得分都有明显下降。四点注射组患者治疗后的平均主观满意度评分明显高于三点注射组（P=0.028）。不良反应为 3 名患者注射后出现瘀伤，3 名患者出现眼睑紧绷感。 A 型肉毒杆菌毒素注射是治疗鱼尾纹的有效方法。增加第四次注射可保持相同的治疗效果，且不会增加不良反应。下扇形鱼尾纹患者可能从四点注射疗法中获益更多。不过，目前的研究结果还需要样本量更大、随访时间更长、A型肉毒毒素剂量不同的研究来证实。
{"title":"Comparative study of the efficacy of three versus four botulinum toxin type A injection sites to treat crow’s feet lines in Vietnamese patients: A retrospective cohort study","authors":"Quang Minh Nguyen, Mai Le Thi, Hieu Duong Phuc, Ha Vu Thai, Doanh Le Huu","doi":"10.1097/jd9.0000000000000368","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000368","url":null,"abstract":"\u0000 \u0000 Botulinum toxin type A is frequently used to treat crow’s feet lines. However, the optimal dose and injection sites are still controversial. The objective of this study was to compare the efficacy of different botulinum toxin type A injection patterns for the treatment of crow’s feet.\u0000 \u0000 \u0000 \u0000 This single-center, retrospective, cohort study was conducted at the National Hospital of Dermatology. Sixty patients with crow’s feet were recruited and randomly assigned in a 1:1 ratio to receive botulinum toxin type A using either a three-point or a four-point intramuscular injection technique. The treatment efficacy was assessed based on the changes in the Crow’s Feet Grading Scale score at 1, 4 and 16 weeks after treatment.\u0000 \u0000 \u0000 \u0000 After treatment, the average Crow’s Feet Grading Scale score was significantly decreased compared with the pretreatment score at all timepoints (1, 4, and 16 weeks) in both states (dynamic and static). The average subjective patient-rated satisfaction scores after treatment were significantly higher in the four-point injection group than the three-point injection group (P=0.028). The adverse events were post-injection bruising in three patients and a feeling of eyelid tightness in three patients.\u0000 \u0000 \u0000 \u0000 Botulinum toxin type A injection is an effective treatment for crow’s feet. Adding a fourth injection maintains the same therapeutic effect and does not increase adverse effects. Patients with lower-fan crow’s feet patterns may benefit more from four-point injection therapy. However, the present findings require confirmation in studies with larger sample sizes, longer follow-up times, and different botulinum toxin type A doses.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"125 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-17DOI: 10.1097/jd9.0000000000000367
Deepthi Konda, Gopi Krishna Mathurthi, Praneeth Sai Santosh Madhavarapu, V. Sakthivadivel, R. Kolavali, A. Morya
Dyskeratosis congenita (DC) is a rare genodermatosis caused by mutations in various genes encoding the proteins responsible for maintaining the telomere length. It is defined by the presence of three clinical features: nail dystrophy, abnormal skin pigmentation, and oral leukoplakia. We herein report a typical case of DC with all three classical features along with pancytopenia, osteopenia, and epiphora but with no identifiable pathogenic mutations of DC-associated genes. Cutaneous examination revealed areas of hypopigmented and hyperpigmented macules forming a reticular pattern all over the body but mainly over the neck and upper chest, with relative sparing of the face. Skin atrophy with hypopigmentation was observed on the knuckles. The nails showed dystrophy in the form of pterygium, anonychia, and brittleness. The palms showed mild wrinkling with hypopigmented macules. Examination of the oral cavity revealed a white non-removable coating over the tongue and bilateral buccal mucosae (oral leukoplakia); the teeth were normal. Syringing of both eyes was performed by an ophthalmologist, and the patient was diagnosed with punctual stenosis (occlusion of the opening of the lacrimal canaliculus). DC is a genodermatosis caused by germline mutations in genes encoding telomerase-associated components, shelterin proteins, and other regulators of telomere length and replication. Depending upon the gene involved, the mode of inheritance can be X-linked autosomal dominant or autosomal recessive. DC is characterized by the clinical triad of abnormal skin pigmentation, dystrophic nails, and oral leukoplakia. Patients with DC are also known to develop other rare clinical features at later stages, including epiphora, early graying of the hair, premature tooth loss, enteropathy with malabsorption, immune deficiency, esophageal stricture, cardiomyopathy, liver cirrhosis, osteoporosis and avascular necrosis of the bone. Patients with DC are predisposed to the development of malignancies, especially hematological malignancies and head/neck cancer. Management of DC involves a multidisciplinary approach and includes genetic counseling of family members at risk, regular surveillance of the patient for bone marrow failure and malignancies, and treatment of the associated features and any complications. Dyskeratosis congenita (DC) is a rare genodermatosis caused by mutations in various genes encoding telomerase complex. We present a typical case of DC with all three classical features but with no pathogenic mutations of existing DC-associated genes thus raising the possibility of new unidentified genes in the pathogenesis of DC.
先天性甲营养不良症（DC）是一种罕见的遗传性皮肤病，由多种编码维持端粒长度的蛋白质的基因突变引起。它有三个临床特征：指甲营养不良、皮肤色素异常和口腔白斑。我们在此报告了一个典型的 DC 病例，该病例具有所有这三个典型特征，同时伴有泛发型、骨质疏松症和眼睑外翻，但没有发现 DC 相关基因的致病突变。 皮肤检查显示，患者全身出现色素减退和色素沉着斑，形成网状模式，但主要分布在颈部和上胸部，面部相对较少。指关节皮肤萎缩，色素减退。指甲出现翼状胬肉、无甲和脆性萎缩。手掌有轻度皱纹，并伴有色素沉着斑。口腔检查发现，舌头和双侧口腔粘膜上有一层白色不可拆卸的涂层（口腔白斑病）；牙齿正常。眼科医生对患者的双眼进行了注射，诊断为点状狭窄（泪道开口闭塞）。 DC是一种基因皮肤病，由编码端粒相关成分、保护蛋白和其他端粒长度和复制调节因子的基因发生种系突变引起。根据所涉及基因的不同，遗传方式可以是 X 连锁常染色体显性遗传或常染色体隐性遗传。DC 的临床特征是皮肤色素异常、指甲萎缩和口腔白斑。据了解，DC 患者在后期还会出现其他罕见的临床特征，包括眼睑外翻、头发早白、牙齿过早脱落、吸收不良的肠病、免疫缺陷、食管狭窄、心肌病、肝硬化、骨质疏松症和骨无血管性坏死。DC 患者易患恶性肿瘤，尤其是血液恶性肿瘤和头颈癌。对先天性角化病的治疗涉及多学科方法，包括对高危家庭成员进行遗传咨询，定期监测患者是否出现骨髓衰竭和恶性肿瘤，以及治疗相关特征和任何并发症。 先天性角化不良症（DC）是一种罕见的遗传性皮肤病，由编码端粒酶复合物的多种基因突变引起。我们介绍了一个典型的先天性角化病病例，该病例具有所有三个典型特征，但现有的先天性角化病相关基因没有发生致病突变，因此在先天性角化病的发病机制中可能存在新的未发现的基因。
{"title":"Dyskeratosis congenita: beyond the triad and beyond the cause","authors":"Deepthi Konda, Gopi Krishna Mathurthi, Praneeth Sai Santosh Madhavarapu, V. Sakthivadivel, R. Kolavali, A. Morya","doi":"10.1097/jd9.0000000000000367","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000367","url":null,"abstract":"\u0000 \u0000 Dyskeratosis congenita (DC) is a rare genodermatosis caused by mutations in various genes encoding the proteins responsible for maintaining the telomere length. It is defined by the presence of three clinical features: nail dystrophy, abnormal skin pigmentation, and oral leukoplakia.\u0000 We herein report a typical case of DC with all three classical features along with pancytopenia, osteopenia, and epiphora but with no identifiable pathogenic mutations of DC-associated genes.\u0000 \u0000 \u0000 \u0000 Cutaneous examination revealed areas of hypopigmented and hyperpigmented macules forming a reticular pattern all over the body but mainly over the neck and upper chest, with relative sparing of the face. Skin atrophy with hypopigmentation was observed on the knuckles. The nails showed dystrophy in the form of pterygium, anonychia, and brittleness. The palms showed mild wrinkling with hypopigmented macules. Examination of the oral cavity revealed a white non-removable coating over the tongue and bilateral buccal mucosae (oral leukoplakia); the teeth were normal. Syringing of both eyes was performed by an ophthalmologist, and the patient was diagnosed with punctual stenosis (occlusion of the opening of the lacrimal canaliculus).\u0000 \u0000 \u0000 \u0000 DC is a genodermatosis caused by germline mutations in genes encoding telomerase-associated components, shelterin proteins, and other regulators of telomere length and replication. Depending upon the gene involved, the mode of inheritance can be X-linked autosomal dominant or autosomal recessive. DC is characterized by the clinical triad of abnormal skin pigmentation, dystrophic nails, and oral leukoplakia. Patients with DC are also known to develop other rare clinical features at later stages, including epiphora, early graying of the hair, premature tooth loss, enteropathy with malabsorption, immune deficiency, esophageal stricture, cardiomyopathy, liver cirrhosis, osteoporosis and avascular necrosis of the bone. Patients with DC are predisposed to the development of malignancies, especially hematological malignancies and head/neck cancer. Management of DC involves a multidisciplinary approach and includes genetic counseling of family members at risk, regular surveillance of the patient for bone marrow failure and malignancies, and treatment of the associated features and any complications.\u0000 \u0000 \u0000 \u0000 Dyskeratosis congenita (DC) is a rare genodermatosis caused by mutations in various genes encoding telomerase complex. We present a typical case of DC with all three classical features but with no pathogenic mutations of existing DC-associated genes thus raising the possibility of new unidentified genes in the pathogenesis of DC.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"60 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-19DOI: 10.1097/jd9.0000000000000365
Francesca Mazzarella, Bianca Maria Del Forno, Enrico Caporali, A. Costa, Vincenzo Vindigni, F. Bassetto, T. Brambullo
Pilomatricoma, also known as benign calcifying epithelioma of Malherbe, is a follicular tumor originating from cells in the hair follicle matrix. It usually manifests as a firm subcutaneous mass up to 3 cm in size. Less commonly, it may measure >5 cm and in such cases is called giant pilomatricoma. We herein present a case of a subcutaneous lesion that was characterized by aggressive biological behavior and initially thought to be malignant but subsequently found to be a rare angiomyxoid variant of giant pilomatricoma. This case involved a young, healthy woman with a rapidly growing subcutaneous lesion on the distal lateral side of her right arm. An incisional biopsy was performed, and the lesion was diagnosed as hyperplasia of the epidermis and subcutaneous tissue, likely of reactive nature. After radical excision, analysis of the entire specimen led the pathologist to diagnose a rare variant of giant pilomatricoma with angiomyxoid stroma. Classic pilomatricoma is an indolent, slow-growing lesion that is well defined and not fixed to the underlying tissue planes. However, after showing no signs of enlargement for 6 months, the lesion in the present case began to grow in a very unusual and concerning manner, suggesting a skin malignancy. The patient’s young age and the rapid development and large dimensions of the lesion led us to suspect a sarcoma. This case highlights the importance of cooperation between the dermatosurgeon and the pathologist to ensure thorough evaluation of such misleading cases. Such cooperation will guide appropriate management decisions and avoid overtreatment of benign lesions.
{"title":"Giant pilomatricoma with coexisting angiomyxoid stroma histopathology: a case report","authors":"Francesca Mazzarella, Bianca Maria Del Forno, Enrico Caporali, A. Costa, Vincenzo Vindigni, F. Bassetto, T. Brambullo","doi":"10.1097/jd9.0000000000000365","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000365","url":null,"abstract":"\u0000 \u0000 Pilomatricoma, also known as benign calcifying epithelioma of Malherbe, is a follicular tumor originating from cells in the hair follicle matrix. It usually manifests as a firm subcutaneous mass up to 3 cm in size. Less commonly, it may measure >5 cm and in such cases is called giant pilomatricoma.\u0000 We herein present a case of a subcutaneous lesion that was characterized by aggressive biological behavior and initially thought to be malignant but subsequently found to be a rare angiomyxoid variant of giant pilomatricoma.\u0000 \u0000 \u0000 \u0000 This case involved a young, healthy woman with a rapidly growing subcutaneous lesion on the distal lateral side of her right arm. An incisional biopsy was performed, and the lesion was diagnosed as hyperplasia of the epidermis and subcutaneous tissue, likely of reactive nature. After radical excision, analysis of the entire specimen led the pathologist to diagnose a rare variant of giant pilomatricoma with angiomyxoid stroma.\u0000 \u0000 \u0000 \u0000 Classic pilomatricoma is an indolent, slow-growing lesion that is well defined and not fixed to the underlying tissue planes. However, after showing no signs of enlargement for 6 months, the lesion in the present case began to grow in a very unusual and concerning manner, suggesting a skin malignancy. The patient’s young age and the rapid development and large dimensions of the lesion led us to suspect a sarcoma.\u0000 \u0000 \u0000 \u0000 This case highlights the importance of cooperation between the dermatosurgeon and the pathologist to ensure thorough evaluation of such misleading cases. Such cooperation will guide appropriate management decisions and avoid overtreatment of benign lesions.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-19DOI: 10.1097/jd9.0000000000000364
Hao-Hao Wu, You Yi
Pruritus is a common symptom of many skin diseases that seriously affects the physical and mental health of patients. In clinical practice, many patients have pruritus that cannot be effectively improved by conventional treatments. Recent studies have found that pruritus is related to a variety of cells and cytokines that are expected to become therapeutic targets. Biological agents and new small-molecule drugs have shown good prospects in the treatment of pruritus. We searched the PubMed, Embase, Cochrane Library, and other databases for clinical trials and case reports of biological agents and small-molecule drugs in the treatment of pruritus, and reviewed the relevant content. This review provides new ideas for the improvement of pruritus and quality of life of patients with skin diseases.
{"title":"Evaluation of biological agents and small-molecule drugs in the treatment of pruritus caused by various dermatoses","authors":"Hao-Hao Wu, You Yi","doi":"10.1097/jd9.0000000000000364","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000364","url":null,"abstract":"Pruritus is a common symptom of many skin diseases that seriously affects the physical and mental health of patients. In clinical practice, many patients have pruritus that cannot be effectively improved by conventional treatments. Recent studies have found that pruritus is related to a variety of cells and cytokines that are expected to become therapeutic targets. Biological agents and new small-molecule drugs have shown good prospects in the treatment of pruritus. We searched the PubMed, Embase, Cochrane Library, and other databases for clinical trials and case reports of biological agents and small-molecule drugs in the treatment of pruritus, and reviewed the relevant content. This review provides new ideas for the improvement of pruritus and quality of life of patients with skin diseases.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138961371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-07DOI: 10.1097/jd9.0000000000000345
Li-Xia Lu, Shuang Zhao, Mingliang Chen, Xiang Chen, Juan Su
In clinical practice, black-brown-gray pigment granules are common under dermoscopy. However, little is known about their clinical significance. We conducted this study to investigate the dermoscopy features of drug reaction. We searched the clinical database in Xiangya Hospital, Central South University from August 2017 to August 2022. Patients with full information on pigment granules and demographic and pathological findings were entered into the final analysis. Cases were reviewed for information regarding pathological and dermoscopic patterns. Fisher’s exact test was used to examine the correlation between individual histologic variables and established diagnoses. The depth of pigment granules showed a non-normal distribution and was analyzed using a nonparametric test. In total, 83 patients were included in this analysis. The presence of pigment granules under dermoscopy significantly indicated destruction of basal cells or pigment incontinence (91.5%, 76/83). The pigment granules within lesions were divided into uniform and nonuniform patterns with respect to their size, color, and distribution. Uniform granular pigmentation was more likely to be associated with eosinophils (numerous or in aggregates, P<0.001) or perifollicular inflammatory infiltration in the dermis (P=0.008). Notably, uniform granular pigmentation was more likely to be induced by medications. Uniform granular pigmentation under dermoscopy is a novel indicator of a drug reaction and necessitates a detailed inquiry.
{"title":"Uniform granular pigmentation as a novel dermoscopic feature of drug reaction","authors":"Li-Xia Lu, Shuang Zhao, Mingliang Chen, Xiang Chen, Juan Su","doi":"10.1097/jd9.0000000000000345","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000345","url":null,"abstract":"\u0000 \u0000 In clinical practice, black-brown-gray pigment granules are common under dermoscopy. However, little is known about their clinical significance. We conducted this study to investigate the dermoscopy features of drug reaction.\u0000 \u0000 \u0000 \u0000 We searched the clinical database in Xiangya Hospital, Central South University from August 2017 to August 2022. Patients with full information on pigment granules and demographic and pathological findings were entered into the final analysis. Cases were reviewed for information regarding pathological and dermoscopic patterns. Fisher’s exact test was used to examine the correlation between individual histologic variables and established diagnoses. The depth of pigment granules showed a non-normal distribution and was analyzed using a nonparametric test.\u0000 \u0000 \u0000 \u0000 In total, 83 patients were included in this analysis. The presence of pigment granules under dermoscopy significantly indicated destruction of basal cells or pigment incontinence (91.5%, 76/83). The pigment granules within lesions were divided into uniform and nonuniform patterns with respect to their size, color, and distribution. Uniform granular pigmentation was more likely to be associated with eosinophils (numerous or in aggregates, P<0.001) or perifollicular inflammatory infiltration in the dermis (P=0.008). Notably, uniform granular pigmentation was more likely to be induced by medications.\u0000 \u0000 \u0000 \u0000 Uniform granular pigmentation under dermoscopy is a novel indicator of a drug reaction and necessitates a detailed inquiry.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"49 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138593789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-04DOI: 10.1097/jd9.0000000000000359
Fei Hao, Tian Qian
{"title":"Monkeypox: A New Public Health Concern for Dermatologists","authors":"Fei Hao, Tian Qian","doi":"10.1097/jd9.0000000000000359","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000359","url":null,"abstract":"","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138603189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/jd9.0000000000000362
Ya-Qi Cao, Chun-Yu Han, Jianwen Han
Dyschromatosis symmetrica hereditaria (DSH) is a rare autosomal dominantly inherited disease with high penetrance. Patients with DSH display a mixture of hyperpigmented and hypopigmented macules on the dorsal aspects of the extremities and freckle-like macules on the face. We identified mutations in two Chinese pedigrees with DSH using whole-exome sequencing (WES) and verified these mutations with PCR-Sanger sequencing. We found a previously reported mutation, c.2433_2434del (p.A813Qfs*29), in exon 7 of ADAR1 in the patient of pedigree one and a novel mutation, c.3301G>T(p.V1101F), in exon 13 of ADAR1 in the patients of pedigree two. We have identified two gene mutations, one of which may be a novel mutation. At present, the main focus is to improve the color of skin lesions. Laser therapy and sun protection can to some extent alleviate skin lesions. The findings of the current case have expanded the range of ADAR1 mutations associated with DSH and may be of great help for future clinical genetic counseling.
{"title":"ADAR1 gene mutations in two Chinese pedigrees with dyschromatosis symmetrica hereditaria","authors":"Ya-Qi Cao, Chun-Yu Han, Jianwen Han","doi":"10.1097/jd9.0000000000000362","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000362","url":null,"abstract":"\u0000 \u0000 Dyschromatosis symmetrica hereditaria (DSH) is a rare autosomal dominantly inherited disease with high penetrance. Patients with DSH display a mixture of hyperpigmented and hypopigmented macules on the dorsal aspects of the extremities and freckle-like macules on the face.\u0000 \u0000 \u0000 \u0000 We identified mutations in two Chinese pedigrees with DSH using whole-exome sequencing (WES) and verified these mutations with PCR-Sanger sequencing. We found a previously reported mutation, c.2433_2434del (p.A813Qfs*29), in exon 7 of ADAR1 in the patient of pedigree one and a novel mutation, c.3301G>T(p.V1101F), in exon 13 of ADAR1 in the patients of pedigree two.\u0000 \u0000 \u0000 \u0000 We have identified two gene mutations, one of which may be a novel mutation. At present, the main focus is to improve the color of skin lesions. Laser therapy and sun protection can to some extent alleviate skin lesions.\u0000 \u0000 \u0000 \u0000 The findings of the current case have expanded the range of ADAR1 mutations associated with DSH and may be of great help for future clinical genetic counseling.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/jd9.0000000000000363
Yan Ding, Lin Gao, Li He, Dan Jian, Q. Ju, Xian Jiang, Cheng-Xin Li, Tong Lin, W. Lai, Yi Liu, Yan Tian, Baoxi Wang, Xiang Wen, Yan Wu, Lei-Hong Xiang, Bin Yang, Rui Yin, Rong-Ya Yang, Yan Yan, Yin Yang, Cheng Zhou, Li Zhang, Wei-hui Zeng
Chemical peels are widely used to treat various skin diseases and photoaging. Their rational, effective, and safe use has become an important issue in clinical practice. To standardize the clinical use of chemical peels, a group of experts developed this consensus based on the latest research and discussions. This consensus provides specific guidance to clinicians on chemical peels with respect to their classification, peeling agents, mechanisms, indications, contraindications, peeling techniques, and complications.
{"title":"Expert Consensus on the Clinical Application of Chemical Peels in China (2022) #","authors":"Yan Ding, Lin Gao, Li He, Dan Jian, Q. Ju, Xian Jiang, Cheng-Xin Li, Tong Lin, W. Lai, Yi Liu, Yan Tian, Baoxi Wang, Xiang Wen, Yan Wu, Lei-Hong Xiang, Bin Yang, Rui Yin, Rong-Ya Yang, Yan Yan, Yin Yang, Cheng Zhou, Li Zhang, Wei-hui Zeng","doi":"10.1097/jd9.0000000000000363","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000363","url":null,"abstract":"Chemical peels are widely used to treat various skin diseases and photoaging. Their rational, effective, and safe use has become an important issue in clinical practice. To standardize the clinical use of chemical peels, a group of experts developed this consensus based on the latest research and discussions. This consensus provides specific guidance to clinicians on chemical peels with respect to their classification, peeling agents, mechanisms, indications, contraindications, peeling techniques, and complications.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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