Pub Date : 2023-11-15DOI: 10.1097/jd9.0000000000000360
Marwa A. Aboelmagd, Hanan A. Assaf, Mohammed H. Hassan, Hanan A. Abdelmegeed, Ashraf Abdelwahab
Vitiligo is a relatively common skin disfiguring disorder that exhibits a fluctuating course between activity and stability, making monitoring and management challenging. Autoimmunity plays a crucial role in the pathogenesis of vitiligo. Numerous autoimmune disorders have been associated with both CD27 and chemokine (C-X-C motif) ligand 10 (CXCL10). However, trials evaluating their role in vitiligo are lacking in the Egyptian setting. We evaluated the circulating levels of these two biomarkers in patients with vitiligo and the possible correlation between their levels and disease activity. This cross-sectional study included 70 patients with vitiligo and 20 healthy controls. The patients were clinically assessed and then divided into active and stable groups according to clinical signs of activity and Vitiligo Disease Activity Scores. The levels of CD27 and CXCL10 in the serum were assessed using an enzyme-linked immunosorbent assay in both the patients and the controls, then the Mann-Whitney and Kruskal Wallis tests were used to analyze the data. Active and stable vitiligo patients have significantly higher median serum CXCL10 (385.9, and 245.2 pg/ml) and CD27 (61.6, and 66.5 ng/ml) levels compared to the controls (193 pg/ml, and 52.5 ng/ml respectively), p˂0.05 for all. In vitiligo cases, although CXCL10 levels significantly increased with disease activity (P < 0.001), CD27 levels were comparable between the two subgroups (P =0.953). CXCL10 positively correlated with disease activity (r=0.887, P < 0.0001). CXCL10 had higher sensitivity and lower specificity (95.7% and 60% respectively) compared to CD27 (71.4% and 75%, respectively) for differentiating cases from controls. There is a possibility that CXCL10 and CD27 are involved in the development and course of vitiligo.
{"title":"Evaluation of Serum Soluble CD27 and CXCL-10 Levels in Patients with Vitiligo","authors":"Marwa A. Aboelmagd, Hanan A. Assaf, Mohammed H. Hassan, Hanan A. Abdelmegeed, Ashraf Abdelwahab","doi":"10.1097/jd9.0000000000000360","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000360","url":null,"abstract":"Vitiligo is a relatively common skin disfiguring disorder that exhibits a fluctuating course between activity and stability, making monitoring and management challenging. Autoimmunity plays a crucial role in the pathogenesis of vitiligo. Numerous autoimmune disorders have been associated with both CD27 and chemokine (C-X-C motif) ligand 10 (CXCL10). However, trials evaluating their role in vitiligo are lacking in the Egyptian setting. We evaluated the circulating levels of these two biomarkers in patients with vitiligo and the possible correlation between their levels and disease activity. This cross-sectional study included 70 patients with vitiligo and 20 healthy controls. The patients were clinically assessed and then divided into active and stable groups according to clinical signs of activity and Vitiligo Disease Activity Scores. The levels of CD27 and CXCL10 in the serum were assessed using an enzyme-linked immunosorbent assay in both the patients and the controls, then the Mann-Whitney and Kruskal Wallis tests were used to analyze the data. Active and stable vitiligo patients have significantly higher median serum CXCL10 (385.9, and 245.2 pg/ml) and CD27 (61.6, and 66.5 ng/ml) levels compared to the controls (193 pg/ml, and 52.5 ng/ml respectively), p˂0.05 for all. In vitiligo cases, although CXCL10 levels significantly increased with disease activity (P < 0.001), CD27 levels were comparable between the two subgroups (P =0.953). CXCL10 positively correlated with disease activity (r=0.887, P < 0.0001). CXCL10 had higher sensitivity and lower specificity (95.7% and 60% respectively) compared to CD27 (71.4% and 75%, respectively) for differentiating cases from controls. There is a possibility that CXCL10 and CD27 are involved in the development and course of vitiligo.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139273199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.1097/jd9.0000000000000356
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
{"title":"A Study of Normal Epidermal Melanocyte Distribution: Erratum","authors":"","doi":"10.1097/jd9.0000000000000356","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000356","url":null,"abstract":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.1097/jd9.0000000000000358
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
{"title":"Linagliptin-Associated Bullous Pemphigoid: The First Case in China: Erratum","authors":"","doi":"10.1097/jd9.0000000000000358","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000358","url":null,"abstract":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.1097/jd9.0000000000000357
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
{"title":"Erosive Pustular Dermatosis of the Scalp After Excision and Skin Grafting of Scalp Squamous Cell Carcinoma: Erratum","authors":"","doi":"10.1097/jd9.0000000000000357","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000357","url":null,"abstract":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-02DOI: 10.1097/jd9.0000000000000355
Tian-ze Yu, Wei Li
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease. Skin microbiota disorder, skin barrier dysfunction, and predominantly elevated type 2 immune responses are core initiate mechanisms of AD. Cutibacterium acnes ( C. acnes ) is a commensal bacterium that is ubiquitous and predominant in healthy skin, with intraspecific subtype diversity. The abundance of C. acnes is closely related to the sebum secreted by sebaceous glands. C. acnes has long been considered a pro-inflammatory skin bacteria that drives the development of acne vulgaris. Growing evidence supports C. acnes promotes the skin microbiota homeostasis and skin barrier maintenance, while the potential role of C. acnes in AD remains largely unexamined. This review provides the latest information on the distribution of C. acnes and its phylotypes in healthy skin and AD, meanwhile offering an overview of the possible role of C. acnes in the pathophysiological pathways underlying AD. Additionally, the review focuses on new evidence regarding the protective functions of C. acnes and its metabolites in AD, with the potential for therapeutic applications.
{"title":"Cutibacterium acnes in Atopic Dermatitis: Roles and Potential Therapeutic Applications","authors":"Tian-ze Yu, Wei Li","doi":"10.1097/jd9.0000000000000355","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000355","url":null,"abstract":"Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease. Skin microbiota disorder, skin barrier dysfunction, and predominantly elevated type 2 immune responses are core initiate mechanisms of AD. Cutibacterium acnes ( C. acnes ) is a commensal bacterium that is ubiquitous and predominant in healthy skin, with intraspecific subtype diversity. The abundance of C. acnes is closely related to the sebum secreted by sebaceous glands. C. acnes has long been considered a pro-inflammatory skin bacteria that drives the development of acne vulgaris. Growing evidence supports C. acnes promotes the skin microbiota homeostasis and skin barrier maintenance, while the potential role of C. acnes in AD remains largely unexamined. This review provides the latest information on the distribution of C. acnes and its phylotypes in healthy skin and AD, meanwhile offering an overview of the possible role of C. acnes in the pathophysiological pathways underlying AD. Additionally, the review focuses on new evidence regarding the protective functions of C. acnes and its metabolites in AD, with the potential for therapeutic applications.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135973307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermatomyositis, an idiopathic inflammatory myopathy, is characterized by distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology Branch of the China International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice.
{"title":"Chinese expert consensus on the diagnosis and treatment of adult dermatomyositis (2022)","authors":"Hua Cao, Aijun Chen, Yong Cui, Danqi Deng, Xinghua Gao, Yanling He, Xiaojing Kang, Hongzhong Jin, Chengxin Li, Feng Li, Hengjin Li, Wenjun Liao, Xiaoming Liu, Qianjin Lu, Yan Lu, Meng Pan, Weihua Pan, Xiaoming Shu, Keyun Tang, Juan Tao, Yu Wang, Ting Xiao, Furen Zhang, Hanlin Zhang","doi":"10.1097/jd9.0000000000000354","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000354","url":null,"abstract":"Dermatomyositis, an idiopathic inflammatory myopathy, is characterized by distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology Branch of the China International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135169327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-17DOI: 10.1097/jd9.0000000000000353
Cui-Hao Song, Rui Wang, Zhen-Kai Zhao, Yuan Zhang, Jie Sun, Xu Zhang, Xiang-Yu Ding, Jia Bai, Xiao-Qiang Liang, Xuan-Jin Wei, Xiao-Ling Liu, Tao Yang, Xin-Lin Liang, Cheng-Xin Li, Bi-Wen Lin
Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: We measured the epidermal leptin, P62, and LC3 concentrations by immunohistochemistry, and measured the serum leptin concentrations by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these concentrations between groups. Additionally, we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins. Next, we transfected ATG5 to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 were again measured. One-way ANOVA was used for the comparison of means of multiple samples, and Tukey's post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum and epidermal leptin concentrations were significantly higher in patients with concomitant psoriasis and MS than in healthy control individuals and patients with psoriasis without MS (serum leptin concentrations: 1330 ± 244.2, 1041 ± 282.7, and 760.4 ± 361.1 pg/mL, P <0.0001; epidermal leptin concentrations 0.589 ± 0.151, 0.393 ± 0.125, and 0.266 ± 0.191 pg/mL, P <0.0001). The level of the autophagy marker LC3 was strongly reduced and that of P62 was strongly increased in the epidermis of patients with concomitant psoriasis and MS compared with healthy control individuals and patients with psoriasis without MS (LC3: 0.274 ± 0.113, 0.291 ± 0.128, and 0.462 ± 0.169, P <0.0001; P62: 0.185 ± 0.075, 0.132 ± 0.030, and 0.099 ± 0.031, P <0.0001). We also observed a positive correlation between leptin and P62 concentrations in the blood ( r =0.4028, P =0.0002) and epidermis ( r =0.2721, P =0.0174), and a negative correlation between serum leptin concentrations and epidermal LC3 concentrations ( r =-0.3944, P =0.0004). In vitro, leptin significantly decreased the autophagy markers Beclin1 and LC3B and increased P62. Western blotting showed that leptin treatment resulted in decreased expression of the differentiation marker K10, and increased expressions of K16 and K17; when the decrease in autophagy was restored by ATG5, this phenomenon was reversed. In addition, lep
目的:银屑病与代谢综合征(MS)的高发率相关，同时伴有银屑病和MS的患者受影响更严重，对治疗的反应更差。然而，这些作用背后的分子机制尚不清楚。最近的研究表明，瘦素可能是银屑病和MS之间的分子联系，提示高瘦素浓度可能会加重银屑病。然而，这种作用的分子机制尚不清楚。我们的目的是研究瘦素对银屑病患者自噬的影响。方法:采用免疫组化法测定小鼠表皮瘦素、P62、LC3浓度，酶联免疫吸附法测定血清瘦素浓度。然后，我们进行了相关分析，比较各组之间的这些浓度。此外，我们在体外培养不同浓度瘦素的HaCaT细胞后进行western blotting，并测量自噬标志物Beclin1、LC3B和P62的表达水平;分化标记K10、K16和K17;以及PI3K/AKT/mTOR信号通路相关蛋白。接下来，我们转染ATG5以恢复自噬，并使用特异性PI3K抑制剂LY294002阻断PI3K/AKT/mTOR信号传导。再次测定K10、K16、K17的表达水平。多样本均数比较采用单因素方差分析，两组比较采用Tukey事后检验。计数资料采用卡方检验。采用Pearson相关分析评价相关性。结果:银屑病合并多发性硬化症患者血清和表皮瘦素浓度显著高于健康对照和无多发性硬化症银屑病患者(血清瘦素浓度分别为1330±244.2、1041±282.7和760.4±361.1 pg/mL, P <0.0001;表皮瘦素浓度分别为0.589±0.151、0.393±0.125和0.266±0.191 pg/mL, P <0.0001)。银屑病合并多发性硬化症患者表皮自噬标志物LC3水平较健康对照和无多发性硬化症银屑病患者明显降低，P62水平明显升高(LC3: 0.274±0.113、0.291±0.128、0.462±0.169,P <0.0001;P62: 0.185±0.075,0.132±0.030,0.099±0.031,P <0.0001)。我们还观察到血清瘦素浓度与P62浓度(r =0.4028, P =0.0002)和表皮清瘦素浓度(r =0.2721, P =0.0174)呈正相关，血清瘦素浓度与表皮LC3浓度呈负相关(r =-0.3944, P =0.0004)。在体外，瘦素显著降低自噬标志物Beclin1和LC3B，升高P62。Western blotting结果显示，瘦素处理导致分化标志物K10表达降低，K16和K17表达升高;当ATG5恢复自噬减少后，这一现象被逆转。此外，与对照组相比，瘦素处理显著上调HaCaT细胞中磷酸化PI3K、AKT和mTOR的表达;当p-PI3K的表达被LY294002显著抑制时，瘦素并没有逆转这些蛋白的表达下降。结论:瘦素与银屑病自噬呈负相关，瘦素通过PI3K/AKT/mTOR通路下调自噬，从而显著降低自噬，影响角化细胞分化。优化银屑病伴发MS患者的治疗具有重要意义。我们的研究增强了对MS与银屑病之间联系的认识，为银屑病伴发MS患者提供了潜在的治疗靶点。
{"title":"Leptin modulates the differentiation of keratinocytes via autophagy in patients with psoriasis and metabolic syndrome","authors":"Cui-Hao Song, Rui Wang, Zhen-Kai Zhao, Yuan Zhang, Jie Sun, Xu Zhang, Xiang-Yu Ding, Jia Bai, Xiao-Qiang Liang, Xuan-Jin Wei, Xiao-Ling Liu, Tao Yang, Xin-Lin Liang, Cheng-Xin Li, Bi-Wen Lin","doi":"10.1097/jd9.0000000000000353","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000353","url":null,"abstract":"Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: We measured the epidermal leptin, P62, and LC3 concentrations by immunohistochemistry, and measured the serum leptin concentrations by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these concentrations between groups. Additionally, we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins. Next, we transfected ATG5 to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 were again measured. One-way ANOVA was used for the comparison of means of multiple samples, and Tukey's post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum and epidermal leptin concentrations were significantly higher in patients with concomitant psoriasis and MS than in healthy control individuals and patients with psoriasis without MS (serum leptin concentrations: 1330 ± 244.2, 1041 ± 282.7, and 760.4 ± 361.1 pg/mL, P <0.0001; epidermal leptin concentrations 0.589 ± 0.151, 0.393 ± 0.125, and 0.266 ± 0.191 pg/mL, P <0.0001). The level of the autophagy marker LC3 was strongly reduced and that of P62 was strongly increased in the epidermis of patients with concomitant psoriasis and MS compared with healthy control individuals and patients with psoriasis without MS (LC3: 0.274 ± 0.113, 0.291 ± 0.128, and 0.462 ± 0.169, P <0.0001; P62: 0.185 ± 0.075, 0.132 ± 0.030, and 0.099 ± 0.031, P <0.0001). We also observed a positive correlation between leptin and P62 concentrations in the blood ( r =0.4028, P =0.0002) and epidermis ( r =0.2721, P =0.0174), and a negative correlation between serum leptin concentrations and epidermal LC3 concentrations ( r =-0.3944, P =0.0004). In vitro, leptin significantly decreased the autophagy markers Beclin1 and LC3B and increased P62. Western blotting showed that leptin treatment resulted in decreased expression of the differentiation marker K10, and increased expressions of K16 and K17; when the decrease in autophagy was restored by ATG5, this phenomenon was reversed. In addition, lep","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136037737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Vascular lesions, such as port wine stain (PWS), lead to facial and psychological problems that require careful and timely treatments. This review aims to compare two mainstream methods pulsed dye laser (PDL) therapy and photodynamic therapy (PDT) for PWS. Methods: The Cochrane Library, PubMed, Embase, CNKI Full-Text Chinese Database and VIP Chinese Scientific Journals Database were searched for literatures comparing PDL versus PDT in treating PWS with no dates set. Studies were eligible for inclusion if they were randomised, placebo-controlled or head-to-head trials published in either English or Chinese. The primary outcome was overall response rate judged by physician/investigator-reported outcome scoring system. Adverse effects were also recorded. Review Manager (RevMan) was used to perform data synthesis. Cochrane risk of bias tool was used for methodological quality assessment. Retrospective studies were assessed based on Newcastle-Ottawa Scale. Results: Twelve studies met the inclusion criteria, among which eight studies had the data necessary for the meta-analysis. Among the eight studies, four were retrospective studies with 1,075 patients. The other four were RCT studies with 532 randomised participants. Regarding the overall response rate of RCT studies, PDT demonstrated no significantly higher efficacy than PDL with RR 0.76 (95% credible interval [CI] 0.48–1.20). Regarding purple types, the overall response rate of PDT was statistically significantly superior to that of PDL with RR of 0.47 (95% CI: 0.29–0.79). In terms of red types, PDT also manifested no significantly higher efficacy compared with PDL with RR of 0.85 (95% CI : 0.27–2.71). Conclusion: PDT is an effective and safe treatment for different types of PWS and was more effective than PDL in treating purple type of PWS.
{"title":"Pulsed dye laser (PDL) versus photodynamic therapy (PDT) for the treatment of port wine stain (PWS): a systematic review and meta-analysis","authors":"Yi-Di Liu, Ying Wang, Jing Zeng, Hui Li, Hai-Xia Qiu, Ying Gu","doi":"10.1097/jd9.0000000000000352","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000352","url":null,"abstract":"Objective: Vascular lesions, such as port wine stain (PWS), lead to facial and psychological problems that require careful and timely treatments. This review aims to compare two mainstream methods pulsed dye laser (PDL) therapy and photodynamic therapy (PDT) for PWS. Methods: The Cochrane Library, PubMed, Embase, CNKI Full-Text Chinese Database and VIP Chinese Scientific Journals Database were searched for literatures comparing PDL versus PDT in treating PWS with no dates set. Studies were eligible for inclusion if they were randomised, placebo-controlled or head-to-head trials published in either English or Chinese. The primary outcome was overall response rate judged by physician/investigator-reported outcome scoring system. Adverse effects were also recorded. Review Manager (RevMan) was used to perform data synthesis. Cochrane risk of bias tool was used for methodological quality assessment. Retrospective studies were assessed based on Newcastle-Ottawa Scale. Results: Twelve studies met the inclusion criteria, among which eight studies had the data necessary for the meta-analysis. Among the eight studies, four were retrospective studies with 1,075 patients. The other four were RCT studies with 532 randomised participants. Regarding the overall response rate of RCT studies, PDT demonstrated no significantly higher efficacy than PDL with RR 0.76 (95% credible interval [CI] 0.48–1.20). Regarding purple types, the overall response rate of PDT was statistically significantly superior to that of PDL with RR of 0.47 (95% CI: 0.29–0.79). In terms of red types, PDT also manifested no significantly higher efficacy compared with PDL with RR of 0.85 (95% CI : 0.27–2.71). Conclusion: PDT is an effective and safe treatment for different types of PWS and was more effective than PDL in treating purple type of PWS.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136181955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1097/jd9.0000000000000351
Wen-Jia Nie, Xin-Yue Zhang, Yu-Ting Xia, Bi-ling Jiang, Zhen Cai, Yan Liu, Ayan Hasen, Juan Tao, Yan Li
Infantile hemangioma is the most common benign vascular tumor of infancy and is characterized by a unique life cycle. Animal models that reflect the histological and biological characteristics of infantile hemangioma are critical tools for preclinical studies. Various infantile hemangioma animal models have been developed and improved during the past few decades. However, very few reports have provided practical suggestions for selecting a suitable animal model based on the study purpose. This comprehensive review summarizes the construction methods and application scenarios of different models. The advantages and disadvantages of each model are fully discussed, providing a reference for choosing the most applicable animal model for infantile hemangioma-associated research.
{"title":"Murine Models of Infantile Hemangioma: A Comprehensive Review","authors":"Wen-Jia Nie, Xin-Yue Zhang, Yu-Ting Xia, Bi-ling Jiang, Zhen Cai, Yan Liu, Ayan Hasen, Juan Tao, Yan Li","doi":"10.1097/jd9.0000000000000351","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000351","url":null,"abstract":"Infantile hemangioma is the most common benign vascular tumor of infancy and is characterized by a unique life cycle. Animal models that reflect the histological and biological characteristics of infantile hemangioma are critical tools for preclinical studies. Various infantile hemangioma animal models have been developed and improved during the past few decades. However, very few reports have provided practical suggestions for selecting a suitable animal model based on the study purpose. This comprehensive review summarizes the construction methods and application scenarios of different models. The advantages and disadvantages of each model are fully discussed, providing a reference for choosing the most applicable animal model for infantile hemangioma-associated research.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Elderly atopic dermatitis (AD) is a newly identified subtype of AD. Whether specific diagnostic criteria are needed for elderly AD has been debated. This study aimed to propose diagnostic criteria for elderly AD and evaluate the sensitivity. Methods: A hospital-based study was conducted. We screened the clinical features of 1312 patients with AD of different ages in one cohort and proposed a set of diagnostic criteria for elderly AD. The criteria were then validated in another cohort of 223 patients clinically diagnosed with elderly AD by dermatologists specialized in AD to examine the diagnostic sensitivity compared with other criteria by chi-square test. Results: Based on the patients’ clinical features, a set of diagnostic criteria for elderly AD were proposed. The new diagnostic criteria showed significantly higher sensitivity than the classical diagnostic criteria (P<0.001), especially for mild and moderate AD (P<0.001）. Of all 223 patients with elderly AD, 93.3% fulfilled our criteria, while only 43.5%, 65.5%, and 52.0% fulfilled the Hanifin and Rajka criteria, the Japanese Dermatology Academy criteria, and the United Kingdom Working Party criteria, respectively. Conclusion: The newly proposed criteria for elderly AD yielded high diagnostic sensitivity, particularly for mild and moderate AD.
{"title":"Development and validation of diagnostic criteria for elderly atopic dermatitis","authors":"Shang-Shang Wang, Zheng Li, Chao-Ying Gu, Hui-Bin Yin, Yue-Meng Wu, Xu Yao, Wei Li","doi":"10.1097/jd9.0000000000000349","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000349","url":null,"abstract":"Objective: Elderly atopic dermatitis (AD) is a newly identified subtype of AD. Whether specific diagnostic criteria are needed for elderly AD has been debated. This study aimed to propose diagnostic criteria for elderly AD and evaluate the sensitivity. Methods: A hospital-based study was conducted. We screened the clinical features of 1312 patients with AD of different ages in one cohort and proposed a set of diagnostic criteria for elderly AD. The criteria were then validated in another cohort of 223 patients clinically diagnosed with elderly AD by dermatologists specialized in AD to examine the diagnostic sensitivity compared with other criteria by chi-square test. Results: Based on the patients’ clinical features, a set of diagnostic criteria for elderly AD were proposed. The new diagnostic criteria showed significantly higher sensitivity than the classical diagnostic criteria (P<0.001), especially for mild and moderate AD (P<0.001）. Of all 223 patients with elderly AD, 93.3% fulfilled our criteria, while only 43.5%, 65.5%, and 52.0% fulfilled the Hanifin and Rajka criteria, the Japanese Dermatology Academy criteria, and the United Kingdom Working Party criteria, respectively. Conclusion: The newly proposed criteria for elderly AD yielded high diagnostic sensitivity, particularly for mild and moderate AD.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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