Advances in medical sciences最新文献_第4页

Association of systemic immune–inflammation index with in-hospital mortality of cardiogenic shock patients supported with extracorporeal membrane oxygenation 体外膜氧合支持下心源性休克患者全身免疫炎症指数与住院死亡率的关系

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-05-03 DOI: 10.1016/j.advms.2025.04.002

Shixing Li , Hao Wang , Jin Yu, Jingsong Xu, Yan Xu

Purpose

The systemic immune-inflammation index (SII) is a useful predictor in cardiovascular diseases. The purpose of this study was to investigate the association of SII with in–hospital mortality in patients with cardiogenic shock (CS) supported with extracorporeal membrane oxygenation (ECMO).

Patients and Methods

A total of 126 CS patients received ECMO implantation between January 2020 and December 2023. SII was calculated as follows: SII = neutrophil count × platelet count / lymphocyte count at admission. Participants were divided into high or low SII group based on the cut–off value of SII. In–hospital mortality was compared between the groups.

Results

The optimal SII cut–off value for predicting in–hospital mortality in CS patients supported with ECMO was 1735.9 (AUC 0.68, p = 0.001). In–hospital mortality was significantly higher in the high SII group compared to the low SII group (59.09 % vs. 21.67 %, p <0.001). The univariate and multivariate logistic regression analyses had shown that SII and left ventricular ejection fraction (LVEF) were identified as independent predictors of in–hospital mortality in CS patients supported with ECMO (OR: 1.001, 95 % CI: 1.000–1.002, p = 0.007 and OR: 0.881, 95 % CI: 0.803–0.966, p = 0.007, respectively). SII combined with LVEF offered a superior prognostic capability compared to SII alone (AUC 0.707, v. s. AUC 0.68).

Conclusion

We demonstrated that elevated admission SII was independently associated with in-hospital mortality in CS patients supported with ECMO. These findings highlight the potential role of SII as an indicator of mortality risk in this population.

目的：全身免疫炎症指数（SII）是心血管疾病的有效预测指标。本研究的目的是探讨SII与体外膜氧合（ECMO）支持的心源性休克（CS）患者住院死亡率的关系。患者和方法：2020年1月至2023年12月，共126例CS患者接受ECMO植入。SII计算公式如下：SII =入院时中性粒细胞计数×血小板计数/淋巴细胞计数。根据SII的临界值将参与者分为高SII组和低SII组。比较两组之间的住院死亡率。结果：预测经ECMO支持的CS患者住院死亡率的最佳SII临界值为1735.9 （AUC 0.68, p = 0.001）。高SII组的住院死亡率明显高于低SII组（59.09% vs. 21.67%, p）结论：我们证明了入院SII升高与ECMO支持下CS患者的住院死亡率独立相关。这些发现强调了SII作为该人群死亡风险指标的潜在作用。

{"title":"Association of systemic immune–inflammation index with in-hospital mortality of cardiogenic shock patients supported with extracorporeal membrane oxygenation","authors":"Shixing Li , Hao Wang , Jin Yu, Jingsong Xu, Yan Xu","doi":"10.1016/j.advms.2025.04.002","DOIUrl":"10.1016/j.advms.2025.04.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The systemic immune-inflammation index (SII) is a useful predictor in cardiovascular diseases. The purpose of this study was to investigate the association of SII with in–hospital mortality in patients with cardiogenic shock (CS) supported with extracorporeal membrane oxygenation (ECMO).</div></div><div><h3>Patients and Methods</h3><div>A total of 126 CS patients received ECMO implantation between January 2020 and December 2023. SII was calculated as follows: SII = neutrophil count × platelet count / lymphocyte count at admission. Participants were divided into high or low SII group based on the cut–off value of SII. In–hospital mortality was compared between the groups.</div></div><div><h3>Results</h3><div>The optimal SII cut–off value for predicting in–hospital mortality in CS patients supported with ECMO was 1735.9 (AUC 0.68, <em>p</em> = 0.001). In–hospital mortality was significantly higher in the high SII group compared to the low SII group (59.09 % vs. 21.67 %, <em>p</em> <0.001). The univariate and multivariate logistic regression analyses had shown that SII and left ventricular ejection fraction (LVEF) were identified as independent predictors of in–hospital mortality in CS patients supported with ECMO (OR: 1.001, 95 % CI: 1.000–1.002, <em>p</em> = 0.007 and OR: 0.881, 95 % CI: 0.803–0.966, <em>p</em> = 0.007, respectively). SII combined with LVEF offered a superior prognostic capability compared to SII alone (AUC 0.707, v. s. AUC 0.68).</div></div><div><h3>Conclusion</h3><div>We demonstrated that elevated admission SII was independently associated with in-hospital mortality in CS patients supported with ECMO. These findings highlight the potential role of SII as an indicator of mortality risk in this population.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 243-247"},"PeriodicalIF":2.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen (rs3134646) and ARHGAP15 (rs4662344) genetic variants may predispose to colonic diverticulosis 胶原蛋白（rs3134646）和ARHGAP15 （rs4662344）基因变异可能易患结肠憩室病

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-04-22 DOI: 10.1016/j.advms.2025.04.001

Piotr Nehring , Grzegorz Placha , Adam Przybyłkowski

Purpose

Colonic diverticulosis is a common condition in older adults in the entire world. Besides environmental factors, there are emerging data on underlying genetic predisposition to diverticula formation. The study aimed to identify genetic factors associated with colonic diverticulosis.

Patients and methods

The study involved 323 patients, 134 with colonic diverticulosis, and 189 healthy controls. In all study participants the following genetic variants were assessed using RT-PCR: rs1800587 in IL1, rs16944, and rs2853550 in IL1B, rs3134646, and rs6434304 in COL3A1, rs3771810, and rs3771863 in TACR1, rs4644560 in NK2R, rs4662344 in ARHGAP15, rs67153654 in FAM155A, and rs7848647 in TNFSF15.

Results

Both, the allele C of the COL3A1 (rs3134646) variant and allele T of the ARHGAP15 (rs4662344) variant, were shown to be associated with diverticulosis, compared to healthy controls in co-dominant and recessive models. Both of them were more frequently reported in patients with colonic diverticulosis, compared to healthy controls.

There were no allelic or genetic associations in patients with diverticulosis or diverticulitis compared to healthy controls, for the following genetic variants: IL1A (rs1800587), IL1B (rs16944, rs2853550), COL3A1 (rs6434304), TACR1 (rs3771810, rs3771863), NK2R (rs4644560), FAM155A (rs67153654) and TNFSF15 (rs7848647).

Conclusions

The allele C of COL3A1 (rs3134646) and allele T of the ARHGAP15 (rs4662344) may predispose to colonic diverticulosis. When viewed in the context of previous studies, these findings suggest that the development of colonic diverticula may be influenced by the involvement and degradation of the extracellular matrix.

目的：结肠憩室病是世界范围内老年人的常见病。除了环境因素外，关于憩室形成的潜在遗传易感性的数据也在不断涌现。该研究旨在确定与结肠憩室病相关的遗传因素。患者和方法本研究纳入323例患者，134例结肠憩室病，189例健康对照。在所有研究参与者中，使用RT-PCR评估以下遗传变异：IL1中的rs1800587、IL1B中的rs16944和rs2853550、COL3A1中的rs3134646和rs6434304、TACR1中的rs3771810和rs3771863、NK2R中的rs4644560、ARHGAP15中的rs4662344、FAM155A中的rs67153654和TNFSF15中的rs7848647。结果在共显性和隐性模型中，与健康对照相比，COL3A1 （rs3134646）变异的等位基因C和ARHGAP15 （rs4662344）变异的等位基因T都与憩室病有关。与健康对照组相比，这两种情况在结肠憩室病患者中更常见。与健康对照组相比，憩室病或憩室炎患者的以下遗传变异：IL1A （rs1800587）、IL1B （rs16944、rs2853550）、COL3A1 （rs6434304）、TACR1 （rs3771810、rs3771863）、NK2R （rs4644560）、FAM155A （rs67153654）和TNFSF15 （rs7848647）没有等位基因或遗传关联。结论COL3A1等位基因C （rs3134646）和ARHGAP15等位基因T （rs4662344）可能易患结肠憩室病。从以往的研究来看，这些发现表明结肠憩室的发育可能受到细胞外基质的受累和降解的影响。

{"title":"Collagen (rs3134646) and ARHGAP15 (rs4662344) genetic variants may predispose to colonic diverticulosis","authors":"Piotr Nehring , Grzegorz Placha , Adam Przybyłkowski","doi":"10.1016/j.advms.2025.04.001","DOIUrl":"10.1016/j.advms.2025.04.001","url":null,"abstract":"<div><h3>Purpose</h3><div>Colonic diverticulosis is a common condition in older adults in the entire world. Besides environmental factors, there are emerging data on underlying genetic predisposition to diverticula formation. The study aimed to identify genetic factors associated with colonic diverticulosis.</div></div><div><h3>Patients and methods</h3><div>The study involved 323 patients, 134 with colonic diverticulosis, and 189 healthy controls. In all study participants the following genetic variants were assessed using RT-PCR: rs1800587 in <em>IL1</em>, rs16944, and rs2853550 in <em>IL1B</em>, rs3134646, and rs6434304 in <em>COL3A1</em>, rs3771810, and rs3771863 in <em>TACR1</em>, rs4644560 in <em>NK2R</em>, rs4662344 in <em>ARHGAP15</em>, rs67153654 in <em>FAM155A</em>, and rs7848647 in <em>TNFSF15</em>.</div></div><div><h3>Results</h3><div>Both, the allele C of the <em>COL3A1</em> (rs3134646) variant and allele T of the <em>ARHGAP15</em> (rs4662344) variant, were shown to be associated with diverticulosis, compared to healthy controls in co-dominant and recessive models. Both of them were more frequently reported in patients with colonic diverticulosis, compared to healthy controls.</div><div>There were no allelic or genetic associations in patients with diverticulosis or diverticulitis compared to healthy controls, for the following genetic variants: <em>IL1A</em> (rs1800587), <em>IL1B</em> (rs16944, rs2853550), <em>COL3A1</em> (rs6434304), <em>TACR1</em> (rs3771810, rs3771863), <em>NK2R</em> (rs4644560), <em>FAM155A</em> (rs67153654) and <em>TNFSF15</em> (rs7848647).</div></div><div><h3>Conclusions</h3><div>The allele C of <em>COL3A1</em> (rs3134646) and allele T of the <em>ARHGAP15</em> (rs4662344) may predispose to colonic diverticulosis. When viewed in the context of previous studies, these findings suggest that the development of colonic diverticula may be influenced by the involvement and degradation of the extracellular matrix.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 2","pages":"Pages 231-236"},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of salusin-β in paediatric patients with chronic kidney disease or hypertension 慢性肾病或高血压患儿salusin-β的评价

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.02.006

Mirjam Močnik , Sonja Golob Jančič , Martina Filipič , Evgenija Homšak , Mateja Svetej , Nataša Marčun Varda

Purpose

Salusins are newly identified endogenous peptides implicated in the atherosclerotic process. Salusin-β, in particular, is recognized for its proatherogenic role. Given that atherosclerosis can commence in childhood, salusin-β holds promise as a potential biomarker for cardiovascular risk assessment. The objective of our study was to investigate salusin-β levels in children with early stages of chronic kidney disease (CKD) or hypertension (HTN), and compare them to healthy controls. Furthermore, we aimed to evaluate its association with obesity and pulse wave velocity (PWV), the latter being a well-established marker for determining arterial elasticity.

Materials and methods

This cross-sectional study involved 96 paediatric patients, including 46 with CKD and 50 with HTN, as well as 33 healthy controls. Anthropometric measurements, PWV assessments, serum salusin-β values, and basic laboratory investigations were conducted for all participants.

Results

Salusin-β levels were found to be elevated in patients with CKD (p = 0.014), but not in patients with HTN when compared to healthy controls. When correlating salusin-β levels with PWV, a significant but weak correlation was observed (r = 0.211, p = 0.020).

Conclusions

Salusin-β levels were elevated in paediatric patients with CKD. Additionally, salusin-β levels correlated significantly with PWV. Obesity played a smaller role in these correlations, with significant correlations observed only after combining cardiovascular risk factors revealing certain associations between salusin-β levels and some cardiovascular variables, but with inconclusive findings and, in some instances, even contrary to anticipated outcomes.

目的alusins是新发现的与动脉粥样硬化过程有关的内源性肽。特别是Salusin-β，被认为具有促进动脉粥样硬化的作用。鉴于动脉粥样硬化可以在儿童时期开始，salusin-β有望成为心血管风险评估的潜在生物标志物。本研究的目的是调查早期慢性肾脏疾病（CKD）或高血压（HTN）儿童的salusin-β水平，并将其与健康对照进行比较。此外，我们旨在评估其与肥胖和脉搏波速度（PWV）的关系，后者是确定动脉弹性的公认标志。材料和方法本横断面研究纳入96例儿科患者，包括46例CKD患者和50例HTN患者，以及33例健康对照。对所有参与者进行了人体测量、PWV评估、血清salusin-β值和基础实验室调查。结果与健康对照相比，CKD患者的salusin -β水平升高（p = 0.014），而HTN患者的salusin -β水平没有升高。当salusin-β水平与PWV相关时，观察到显著但微弱的相关性（r = 0.211, p = 0.020）。结论儿童CKD患者salusin -β水平升高。此外，salusin-β水平与PWV显著相关。肥胖在这些相关性中所起的作用较小，只有在结合心血管危险因素揭示salusin-β水平与一些心血管变量之间的某些关联后，才能观察到显著的相关性，但结果不确定，在某些情况下，甚至与预期结果相反。

{"title":"Evaluation of salusin-β in paediatric patients with chronic kidney disease or hypertension","authors":"Mirjam Močnik , Sonja Golob Jančič , Martina Filipič , Evgenija Homšak , Mateja Svetej , Nataša Marčun Varda","doi":"10.1016/j.advms.2025.02.006","DOIUrl":"10.1016/j.advms.2025.02.006","url":null,"abstract":"<div><h3>Purpose</h3><div>Salusins are newly identified endogenous peptides implicated in the atherosclerotic process. Salusin-β, in particular, is recognized for its proatherogenic role. Given that atherosclerosis can commence in childhood, salusin-β holds promise as a potential biomarker for cardiovascular risk assessment. The objective of our study was to investigate salusin-β levels in children with early stages of chronic kidney disease (CKD) or hypertension (HTN), and compare them to healthy controls. Furthermore, we aimed to evaluate its association with obesity and pulse wave velocity (PWV), the latter being a well-established marker for determining arterial elasticity.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study involved 96 paediatric patients, including 46 with CKD and 50 with HTN, as well as 33 healthy controls. Anthropometric measurements, PWV assessments, serum salusin-β values, and basic laboratory investigations were conducted for all participants.</div></div><div><h3>Results</h3><div>Salusin-β levels were found to be elevated in patients with CKD (<em>p</em> = 0.014), but not in patients with HTN when compared to healthy controls. When correlating salusin-β levels with PWV, a significant but weak correlation was observed (r = 0.211, <em>p</em> = 0.020).</div></div><div><h3>Conclusions</h3><div>Salusin-β levels were elevated in paediatric patients with CKD. Additionally, salusin-β levels correlated significantly with PWV. Obesity played a smaller role in these correlations, with significant correlations observed only after combining cardiovascular risk factors revealing certain associations between salusin-β levels and some cardiovascular variables, but with inconclusive findings and, in some instances, even contrary to anticipated outcomes.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 184-190"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of patients with severe asthma reported to be eligible or non-eligible for biologic therapy in Poland: Results from the international observational study RECOGNISE 波兰报道的符合或不符合生物治疗条件的严重哮喘患者的特征：来自国际观察性研究recognition的结果

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.03.003

Robert M. Mróz , Łukasz Minarowski , Jolanta Biegalska

Purpose

To analyze characteristics of real-world patients with severe asthma in Poland and identify factors determining clinicians’ opinion on the eligibility for biologics.

Methods

In this retrospective, multi-national, single-visit study (NCT03629782), investigators were asked whether the patient might benefit from a referral for further clinical assessment and potentially biologic therapy. Asthma exacerbations and healthcare resource utilization (HCRU) in the last 12 months were documented by the investigators. Patient-reported outcomes included St George's Respiratory Questionnaire (SGRQ) and Asthma Control Questionnaire (ACQ-6).

Results

Of 1025 patients, 146 were enrolled in Poland. Investigators considered 77.4 % of patients eligible for biologics and 22.6 % non-eligible. Patients considered eligible were diagnosed at younger age than non-eligible (median 39 vs 45 years; p = 0.0113) and more frequently had a history of atopy (46 % vs 21.2 %; p = 0.0106). Eligible patients had a higher frequency (93.8 % vs 66.7 %, p < 0.0001) and number of exacerbations (median 2 vs 1, p = 0.0003). Among eligible patients, 81.4 % and among non-eligible, 66.7 % had not well-controlled asthma; long-term oral corticosteroids were used by 46.0 % and 51.5 %, respectively. Short-term corticosteroid use was more frequent in biologics-eligible than in non-eligible patients (82.3 % vs 48.5 %, p < 0.0001). Patients eligible for biologics had a higher median SGRQ total score (64.7 vs 48.4; p = 0.0075) and HRCU (63.7 % vs 9.1 %; p < 0.0001).

Conclusions

In Poland, 3 in 4 patients with severe asthma are recognized by clinicians as potential candidates for biologics. However, eligibility is not associated with long-term oral corticosteroid use, highlighting the need to better inform the physicians about the benefits of biologic therapy.

目的：分析波兰现实世界严重哮喘患者的特征，并确定影响临床医生对生物制剂资格的因素。方法：在这项回顾性、多国、单次来访的研究（NCT03629782）中，研究人员被问及患者是否可能从进一步的临床评估和潜在的生物治疗中获益。研究人员记录了过去12个月的哮喘恶化和医疗资源利用（HCRU）。患者报告的结局包括圣乔治呼吸问卷（SGRQ）和哮喘控制问卷（ACQ-6）。结果：1025例患者中，146例在波兰入组。研究人员认为77.4%的患者符合使用生物制剂的条件，22.6%的患者不符合。被认为符合条件的患者比不符合条件的患者诊断年龄更小(中位39 vs 45岁；P =0.0113)，有特异反应史的患者较多(46% vs 21.2%；p = 0.0106)。符合条件的患者有更高的频率（93.8% vs 66.7%）。结论：在波兰，临床医生认为4例严重哮喘患者中有3例是生物制剂的潜在候选者。然而，适格性与长期口服皮质类固醇使用无关，强调有必要更好地告知医生生物治疗的益处。

{"title":"Characteristics of patients with severe asthma reported to be eligible or non-eligible for biologic therapy in Poland: Results from the international observational study RECOGNISE","authors":"Robert M. Mróz , Łukasz Minarowski , Jolanta Biegalska","doi":"10.1016/j.advms.2025.03.003","DOIUrl":"10.1016/j.advms.2025.03.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze characteristics of real-world patients with severe asthma in Poland and identify factors determining clinicians’ opinion on the eligibility for biologics.</div></div><div><h3>Methods</h3><div>In this retrospective, multi-national, single-visit study (NCT03629782), investigators were asked whether the patient might benefit from a referral for further clinical assessment and potentially biologic therapy. Asthma exacerbations and healthcare resource utilization (HCRU) in the last 12 months were documented by the investigators. Patient-reported outcomes included St George's Respiratory Questionnaire (SGRQ) and Asthma Control Questionnaire (ACQ-6).</div></div><div><h3>Results</h3><div>Of 1025 patients, 146 were enrolled in Poland. Investigators considered 77.4 % of patients eligible for biologics and 22.6 % non-eligible. Patients considered eligible were diagnosed at younger age than non-eligible (median 39 vs 45 years; p = 0.0113) and more frequently had a history of atopy (46 % vs 21.2 %; p = 0.0106). Eligible patients had a higher frequency (93.8 % vs 66.7 %, p < 0.0001) and number of exacerbations (median 2 vs 1, p = 0.0003). Among eligible patients, 81.4 % and among non-eligible, 66.7 % had not well-controlled asthma; long-term oral corticosteroids were used by 46.0 % and 51.5 %, respectively. Short-term corticosteroid use was more frequent in biologics-eligible than in non-eligible patients (82.3 % vs 48.5 %, p < 0.0001). Patients eligible for biologics had a higher median SGRQ total score (64.7 vs 48.4; p = 0.0075) and HRCU (63.7 % vs 9.1 %; p < 0.0001).</div></div><div><h3>Conclusions</h3><div>In Poland, 3 in 4 patients with severe asthma are recognized by clinicians as potential candidates for biologics. However, eligibility is not associated with long-term oral corticosteroid use, highlighting the need to better inform the physicians about the benefits of biologic therapy.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 203-208"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Column chart prediction model for ovarian cancer based on serum ovarian tumor related biomarkers and validation 基于血清卵巢肿瘤相关生物标志物的卵巢癌柱状图预测模型及验证。

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.03.001

Yuting Song , Libo Liu , Jie Gao , Naibao Wu , Jiwei Yin

Purpose

The aim was to study the predictive model and validate serum ovarian tumor-related biomarkers for ovarian cancer histograms.

Method

We randomly selected 181 patients with ovarian tumors and 80 healthy individuals who underwent physical examinations from the hospital's medical record information system as the study participants. Clinical data and detection results of ovarian tumor-related markers such as serum carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and human epididymal protein (HE4) were collected from all study participants for analysis.

Result

Significant differences were found in serum CEA, CA125, CA19-9, and HE4 levels between healthy controls, benign ovarian tumors, and ovarian cancer (P < 0.05). Dysmenorrhea (present), family history (present), age at menarche, menstrual period, number of pregnancies, natural abortion frequency, number of induced abortions, CEA, CA125, CA19-9, HE4 were all influencing factors for the incidence of ovarian cancer (P < 0.05). The number of induced abortions, CEA, CA125, CA19-9, and HE4 were all independent risk factors for ovarian cancer, while the natural abortion frequency was a protective factor for ovarian cancer (P < 0.05). The constructed column chart prediction model had good discrimination and prediction accuracy for ovarian cancer, good clinical utility, and higher predictive performance for ovarian cancer than traditional ROMA models.

Conclusion

The ovarian cancer column chart prediction model based on serum ovarian tumor related markers has good discrimination and prediction accuracy for ovarian cancer, with high clinical utility. Future research may need to incorporate more serum markers related to ovarian cancer to further improve the performance of predictive models.

目的：研究卵巢癌直方图的预测模型并验证血清卵巢肿瘤相关生物标志物。方法：从医院病历信息系统中随机抽取181例卵巢肿瘤患者和80例健康体检者作为研究对象。收集所有受试者血清癌胚抗原（CEA）、碳水化合物抗原125 （CA125）、碳水化合物抗原19-9 （CA19-9）、人附睾蛋白（HE4）等卵巢肿瘤相关标志物的临床资料及检测结果进行分析。结果：健康对照、良性卵巢肿瘤及卵巢癌患者血清CEA、CA125、CA19-9、HE4水平差异均有统计学意义(p)。结论：基于血清卵巢肿瘤相关标志物的卵巢癌柱状图预测模型对卵巢癌有较好的鉴别和预测准确性，具有较高的临床应用价值。未来的研究可能需要纳入更多与卵巢癌相关的血清标志物，以进一步提高预测模型的性能。

{"title":"Column chart prediction model for ovarian cancer based on serum ovarian tumor related biomarkers and validation","authors":"Yuting Song , Libo Liu , Jie Gao , Naibao Wu , Jiwei Yin","doi":"10.1016/j.advms.2025.03.001","DOIUrl":"10.1016/j.advms.2025.03.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim was to study the predictive model and validate serum ovarian tumor-related biomarkers for ovarian cancer histograms.</div></div><div><h3>Method</h3><div>We randomly selected 181 patients with ovarian tumors and 80 healthy individuals who underwent physical examinations from the hospital's medical record information system as the study participants. Clinical data and detection results of ovarian tumor-related markers such as serum carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and human epididymal protein (HE4) were collected from all study participants for analysis.</div></div><div><h3>Result</h3><div>Significant differences were found in serum CEA, CA125, CA19-9, and HE4 levels between healthy controls, benign ovarian tumors, and ovarian cancer (<em>P</em> < 0.05). Dysmenorrhea (present), family history (present), age at menarche, menstrual period, number of pregnancies, natural abortion frequency, number of induced abortions, CEA, CA125, CA19-9, HE4 were all influencing factors for the incidence of ovarian cancer (<em>P</em> < 0.05). The number of induced abortions, CEA, CA125, CA19-9, and HE4 were all independent risk factors for ovarian cancer, while the natural abortion frequency was a protective factor for ovarian cancer (<em>P</em> < 0.05). The constructed column chart prediction model had good discrimination and prediction accuracy for ovarian cancer, good clinical utility, and higher predictive performance for ovarian cancer than traditional ROMA models.</div></div><div><h3>Conclusion</h3><div>The ovarian cancer column chart prediction model based on serum ovarian tumor related markers has good discrimination and prediction accuracy for ovarian cancer, with high clinical utility. Future research may need to incorporate more serum markers related to ovarian cancer to further improve the performance of predictive models.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 209-218"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conduction system optimized cardiac resynchronization therapy– exceptional modality of cardiac pacing in patients with severe heart failure. A hope for non-responders? 传导系统优化心脏再同步化治疗-严重心力衰竭患者心脏起搏的特殊模式。对无反应者的希望？

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.02.008

Jędrzej Michalik , Maciej Sterliński , Ewa Świerżyńska-Wodarska , Aleksandra Klaus , Marek Szołkiewicz

For many years, the apex of the right ventricle (RV) seemed to be a sufficiently good site for ventricular pacing, effectively protecting both the health and life of patients with atrioventricular conduction disorders. However, the studies have demonstrated that this is not an optimal site, since it leads to electrical and mechanical interventricular asynchrony, which in some cases (15–20 %) results in the development of pacing-induced cardiomyopathy (PICM). The introduction of biventricular cardiac resynchronization therapy (BiV-CRT) into clinical practice was a real breakthrough in the development of modern electrotherapy, and conduction system pacing (CSP) has heralded even greater hopes. The CSP-optimized CRT is the most complex modality of CRT, involving the simultaneous pacing of His bundle or its left branch, and additionally, epicardial pacing of the left ventricle. This modality of pacing may represent the most optimal method for spreading the ventricle depolarization wave in severely damaged cardiac muscle and may represent a real hope for patients who do not adequately respond to other forms of CRT.

多年来，右心室尖部（RV）似乎是一个足够好的心室起搏部位，有效地保护了房室传导障碍患者的健康和生命。然而，研究表明，这不是一个最佳的位置，因为它会导致电性和机械性室间不同步，在某些情况下（15-20%）导致起搏性心肌病（PICM）的发展。双心室心脏再同步化治疗（BiV-CRT）进入临床实践是现代电疗发展的一个真正突破，传导系统起搏（CSP）预示着更大的希望。csp优化的CRT是CRT中最复杂的一种方式，包括His束或其左分支的同时起搏，以及左心室的心外膜起搏。这种起搏方式可能代表了在严重受损的心肌中传播心室去极化波的最佳方法，并且可能代表了对其他形式的CRT没有充分反应的患者的真正希望。

{"title":"Conduction system optimized cardiac resynchronization therapy– exceptional modality of cardiac pacing in patients with severe heart failure. A hope for non-responders?","authors":"Jędrzej Michalik , Maciej Sterliński , Ewa Świerżyńska-Wodarska , Aleksandra Klaus , Marek Szołkiewicz","doi":"10.1016/j.advms.2025.02.008","DOIUrl":"10.1016/j.advms.2025.02.008","url":null,"abstract":"<div><div>For many years, the apex of the right ventricle (RV) seemed to be a sufficiently good site for ventricular pacing, effectively protecting both the health and life of patients with atrioventricular conduction disorders. However, the studies have demonstrated that this is not an optimal site, since it leads to electrical and mechanical interventricular asynchrony, which in some cases (15–20 %) results in the development of pacing-induced cardiomyopathy (PICM). The introduction of biventricular cardiac resynchronization therapy (BiV-CRT) into clinical practice was a real breakthrough in the development of modern electrotherapy, and conduction system pacing (CSP) has heralded even greater hopes. The CSP-optimized CRT is the most complex modality of CRT, involving the simultaneous pacing of His bundle or its left branch, and additionally, epicardial pacing of the left ventricle. This modality of pacing may represent the most optimal method for spreading the ventricle depolarization wave in severely damaged cardiac muscle and may represent a real hope for patients who do not adequately respond to other forms of CRT.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 197-202"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trimethylamine N-oxide as a potential prognostic biomarker for mortality in patients with COVID-19 disease 三甲胺n -氧化物作为COVID-19疾病患者死亡率的潜在预后生物标志物

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.02.002

Zinnet Şevval Aksoyalp , Betül Rabia Erdoğan , Saliha Aksun , Melih Kaan Sözmen , Murat Aksun , Cüneyt Kemal Buharalıoğlu , Nagihan Altıncı-Karahan , Nergiz Hacer Turgut , Tijen Kaya-Temiz

Purpose

Trimethylamine N-oxide (TMAO) is suggested as a biomarker for inflammatory and cardiovascular diseases which are identified as risk factors for severe cases of coronavirus disease 2019 (COVID-19). Our primary aim was to assess prognostic potential of serum TMAO levels in predicting COVID-19-related mortality. The secondary aim was to examine the potential of various biochemical parameters, particularly those associated with inflammation or thrombosis, as predictors of mortality.

Patients and methods

In this prospective and single-centre study, COVID-19 patients were categorized as death (group 1) or discharged (group 2) based on their in-hospital mortality status. The characteristics of participants were documented, and clinical data, including TMAO, angiotensin-converting enzyme-2 (ACE2), and neutrophil to lymphocyte ratio (NLR), were determined. The association of these independent variables with the COVID-19-related mortality, was assessed by calculation of crude odds ratios (OR) in bivariate and logistic regression analysis. Receiver operation characteristic (ROC) analysis was used for cut-off values.

Results

The serum levels of TMAO, ACE2 and NLR were markedly higher in group 1 on the days of hospital admission (p < 0.05, p < 0.05, and p < 0.01, respectively). Serum TMAO levels (OR 1.422; 95 % CI [1.067–1.894]; p = 0.016) and NLR (OR 1.166; 95 % CI [1.012–1.343]; p = 0.033) were determined as independent predictors for COVID-19-related mortality with after multivariate logistic regression analysis. The optimal cut-off values were detected as 7.9 ng/ml for TMAO (71 % sensitivity, 68 % specificity, AUC = 0.701).

Conclusions

The findings of this initial study indicate that serum TMAO levels and NLR may be useful in predicting mortality in the early stages of COVID-19.

目的：三甲胺n -氧化物（TMAO）被认为是炎症和心血管疾病的生物标志物，这些疾病被确定为2019冠状病毒病（COVID-19）重症病例的危险因素。我们的主要目的是评估血清TMAO水平在预测covid -19相关死亡率方面的预后潜力。第二个目的是检查各种生化参数的潜力，特别是与炎症或血栓相关的生化参数，作为死亡率的预测因子。患者和方法：在这项前瞻性单中心研究中，根据住院死亡率情况将COVID-19患者分为死亡组（1组）和出院组（2组）。记录参与者的特征，并确定临床数据，包括TMAO，血管紧张素转换酶-2 （ACE2）和中性粒细胞与淋巴细胞比率（NLR）。在双变量和logistic回归分析中，通过计算粗优势比（OR）来评估这些自变量与covid -19相关死亡率的关联。截断值采用受试者工作特征（ROC）分析。结果：1组患者入院当天血清TMAO、ACE2和NLR水平明显升高(p结论：本初步研究结果提示血清TMAO水平和NLR可能有助于预测COVID-19早期死亡率。

{"title":"Trimethylamine N-oxide as a potential prognostic biomarker for mortality in patients with COVID-19 disease","authors":"Zinnet Şevval Aksoyalp , Betül Rabia Erdoğan , Saliha Aksun , Melih Kaan Sözmen , Murat Aksun , Cüneyt Kemal Buharalıoğlu , Nagihan Altıncı-Karahan , Nergiz Hacer Turgut , Tijen Kaya-Temiz","doi":"10.1016/j.advms.2025.02.002","DOIUrl":"10.1016/j.advms.2025.02.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Trimethylamine N-oxide (TMAO) is suggested as a biomarker for inflammatory and cardiovascular diseases which are identified as risk factors for severe cases of coronavirus disease 2019 (COVID-19). Our primary aim was to assess prognostic potential of serum TMAO levels in predicting COVID-19-related mortality. The secondary aim was to examine the potential of various biochemical parameters, particularly those associated with inflammation or thrombosis, as predictors of mortality.</div></div><div><h3>Patients and methods</h3><div>In this prospective and single-centre study, COVID-19 patients were categorized as death (group 1) or discharged (group 2) based on their in-hospital mortality status. The characteristics of participants were documented, and clinical data, including TMAO, angiotensin-converting enzyme-2 (ACE2), and neutrophil to lymphocyte ratio (NLR), were determined. The association of these independent variables with the COVID-19-related mortality, was assessed by calculation of crude odds ratios (OR) in bivariate and logistic regression analysis. Receiver operation characteristic (ROC) analysis was used for cut-off values.</div></div><div><h3>Results</h3><div>The serum levels of TMAO, ACE2 and NLR were markedly higher in group 1 on the days of hospital admission (<em>p</em> < 0.05, <em>p</em> < 0.05, and <em>p</em> < 0.01, respectively). Serum TMAO levels (OR 1.422; 95 % CI [1.067–1.894]; <em>p</em> = 0.016) and NLR (OR 1.166; 95 % CI [1.012–1.343]; <em>p</em> = 0.033) were determined as independent predictors for COVID-19-related mortality with after multivariate logistic regression analysis. The optimal cut-off values were detected as 7.9 ng/ml for TMAO (71 % sensitivity, 68 % specificity, AUC = 0.701).</div></div><div><h3>Conclusions</h3><div>The findings of this initial study indicate that serum TMAO levels and NLR may be useful in predicting mortality in the early stages of COVID-19.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 174-183"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Genome-engineering technologies for modeling and treatment of cystic fibrosis” [Adv Med Sci (2023 Sept) 68(1) 111–120] “用于囊性纤维化建模和治疗的基因组工程技术”的勘误表[Journal of the Advances in Medical Sciences卷68/ 1,111 -120(2023),522]。

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.01.009

Michał Dębczyński , Damian Mojsak , Łukasz Minarowski , Monika Maciejewska , Paweł Lisowski , Robert M. Mróz

引用次数: 0

Determinants and dynamics of the seroprevalence of anti-SARS-CoV-2 antibodies in Poland 波兰抗sars - cov -2抗体血清流行率的决定因素和动态

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.03.002

Justyna Adamczuk , Karol Adam Kamiński , Sebastian Sołomacha , Małgorzata Kazberuk , Magdalena Chlabicz , Piotr Czupryna , Justyna Dunaj-Małyszko , Anna Citko , Paweł Sowa , Marlena Dubatówka , Magda Łapińska , Łukasz Kiszkiel , Łukasz Szczerbiński , Piotr Paweł Laskowski , Maciej Alimowski , Anna Moniuszko-Malinowska

Purpose

In the present study, we aimed to assess the anti-SARS-CoV-2 antibodies in population and in convalescents 6 months after infection with COVID-19.

Patients and methods

The study population consisted of 2 groups, i.e. group I: 232 post-COVID-19 patients, and group II: 544 patients from a population cohort.

Detection of anti-N antibodies was performed with Elecsys Anti-SARS-CoV-2 and anti-S antibodies with LIAISON SARS-CoV-2 S1/S2 IgG tests.

Results

After the Omicron wave, gradual increase in the prevalence of the analyzed antibodies was observed in the general population - up to 92.5 % of anti-S and 69.7 % of anti-N antibodies. In the COVID-19 convalescents, 6 months after infection, 4.3 % and 3.7 % did not generate significant titers of anti-S and anti-N antibodies, respectively. Among patients, who were vaccinated, 1 % did not generate anti-S antibodies. The median age of non-responders was higher than that of responders. Sex did not influence the results. Comparison of anti-N and anti-S antibodies 6 months after infection in the whole group showed higher anti-N titer in patients who suffered from the disease than in the general population. In the general population, 17.4 % of participants had anti-N antibodies, and 9 % had anti-S antibodies, despite no prior vaccination or history of COVID-19.

Conclusions

High prevalence of anti-N antibodies in patients reporting no history of COVID-19 during last wave, even after official end of the pandemic suggests high prevalence of SARS-CoV-2 in the environment and frequent asymptomatic or unspecific COVID-19, what is of high importance from the public health perspective.

目的：在本研究中，我们旨在评估COVID-19感染后6个月人群或恢复期人群的抗sars - cov -2抗体水平。患者和方法：研究人群包括2组，即I组：232例covid -19后患者，II组：544例来自人群队列的患者。采用Elecsys anti- cov -2检测抗n抗体，采用LIAISON SARS-CoV-2 S1/S2 IgG检测抗s抗体。结果：经过欧米克隆波后，所分析的抗体在一般人群中的患病率逐渐增加，抗s抗体和抗n抗体的患病率分别高达92.5%和69.7%。在COVID-19恢复期，感染后6个月，分别有4.3%和3.7%的患者抗s抗体和抗n抗体滴度不显著。在接种疫苗的患者中，1%没有产生抗s抗体。无应答者的年龄中位数高于应答者。性别对结果没有影响。全组感染6个月后抗n和抗s抗体比较显示，患病患者的抗n滴度高于一般人群。在一般人群中，17.4%的参与者有抗n抗体，9%的参与者有抗s抗体，尽管之前没有接种疫苗或COVID-19病史。结论：在上一波疫情中，即使在疫情正式结束后，无COVID-19病史的患者中抗n抗体的高流行率提示环境中SARS-CoV-2的高流行率和无症状或非特异性COVID-19的频繁发生，从公共卫生角度来看具有重要意义。

{"title":"Determinants and dynamics of the seroprevalence of anti-SARS-CoV-2 antibodies in Poland","authors":"Justyna Adamczuk , Karol Adam Kamiński , Sebastian Sołomacha , Małgorzata Kazberuk , Magdalena Chlabicz , Piotr Czupryna , Justyna Dunaj-Małyszko , Anna Citko , Paweł Sowa , Marlena Dubatówka , Magda Łapińska , Łukasz Kiszkiel , Łukasz Szczerbiński , Piotr Paweł Laskowski , Maciej Alimowski , Anna Moniuszko-Malinowska","doi":"10.1016/j.advms.2025.03.002","DOIUrl":"10.1016/j.advms.2025.03.002","url":null,"abstract":"<div><h3>Purpose</h3><div>In the present study, we aimed to assess the anti-SARS-CoV-2 antibodies in population and in convalescents 6 months after infection with COVID-19.</div></div><div><h3>Patients and methods</h3><div>The study population consisted of 2 groups, i.e. group I: 232 post-COVID-19 patients, and group II: 544 patients from a population cohort.</div><div>Detection of anti-N antibodies was performed with Elecsys Anti-SARS-CoV-2 and anti-S antibodies with LIAISON SARS-CoV-2 S1/S2 IgG tests.</div></div><div><h3>Results</h3><div>After the Omicron wave, gradual increase in the prevalence of the analyzed antibodies was observed in the general population - up to 92.5 % of anti-S and 69.7 % of anti-N antibodies. In the COVID-19 convalescents, 6 months after infection, 4.3 % and 3.7 % did not generate significant titers of anti-S and anti-N antibodies, respectively. Among patients, who were vaccinated, 1 % did not generate anti-S antibodies. The median age of non-responders was higher than that of responders. Sex did not influence the results. Comparison of anti-N and anti-S antibodies 6 months after infection in the whole group showed higher anti-N titer in patients who suffered from the disease than in the general population. In the general population, 17.4 % of participants had anti-N antibodies, and 9 % had anti-S antibodies, despite no prior vaccination or history of COVID-19.</div></div><div><h3>Conclusions</h3><div>High prevalence of anti-N antibodies in patients reporting no history of COVID-19 during last wave, even after official end of the pandemic suggests high prevalence of SARS-CoV-2 in the environment and frequent asymptomatic or unspecific COVID-19, what is of high importance from the public health perspective.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 219-228"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High levels of soluble neuropilin −1 in critically ill multiple trauma/surgical patients 多发性创伤/外科危重患者高水平可溶性神经匹林-1

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences

Pub Date : 2025-03-01 DOI: 10.1016/j.advms.2025.02.007

Charikleia S. Vrettou, Chrysi Keskinidou , Alice G. Vassiliou , Georgios Poupouzas, Edison Jahaj, Vassilios Issaris, Evangelia Theodorou, Asimenia Halioti, Vassiliki Giannopoulou, Nikolaos S. Lotsios, Anastasia Kotanidou, Ioanna Dimopoulou

Purpose

Critically ill trauma/surgical patients may experience excessive inflammation, immune and coagulation dysregulation, leading to multiple organ failure (MOF), carrying high mortality rates. Neuropilin-1 (NRP-1) and its soluble isoform (sNRP-1) are implicated in immune response regulation, inflammation, and vascular permeability. This study aimed to investigate the possible role of sNRP-1 in trauma/surgical patients in the intensive care unit (ICU).

Patients and methods

This prospective observational study was conducted in a 31-bed ICU and included 81 patients, 43 of whom were trauma/surgical patients and 38 of whom were matched medical patients, comprising the control group. sNRP-1, interleukin (IL)-6, IL-8, and IL-10 levels were measured on admission to the ICU (within 48 h).

Results

Trauma/surgical patients had significantly higher sNRP-1 (p = 0.027), IL-6, IL-8, and IL-10 levels (p < 0.05) compared to medical patients. In the entire cohort, sNRP-1 correlated positively with the international normalized ratio (INR) (p = 0.017), the activated partial thromboplastin time (p = 0.026), fibrinogen (p = 0.027), alanine aminotransferase (p = 0.024), and C-reactive protein (p = 0.004). Moreover, sNRP-1 correlated negatively with total protein (p = 0.035), albumin (p = 0.005), and platelets (p = 0.033).

Conclusion

sNRP-1 levels were elevated in critically ill trauma/surgical patients compared to matched medical ICU patients. Further research is needed to elucidate the exact role of sNRP-1 in these patients' pathophysiology.

目的：创伤/外科危重患者可能出现过度炎症、免疫和凝血功能失调，导致多器官功能衰竭（MOF），死亡率高。神经匹林-1 （NRP-1）及其可溶性异构体（sNRP-1）参与免疫反应调节、炎症和血管通透性。本研究旨在探讨sNRP-1在重症监护病房（ICU）创伤/外科患者中的可能作用。患者和方法：本前瞻性观察性研究在31张床位的ICU进行，纳入81例患者，其中43例为创伤/外科患者，38例为匹配的内科患者，构成对照组。入院时（48小时内）检测sNRP-1、白细胞介素(IL)-6、IL-8、IL-10水平。结果：创伤/外科患者sNRP-1、IL-6、IL-8、IL-10水平显著升高（p = 0.027）。结论：创伤/外科危重症患者sNRP-1水平高于匹配的内科ICU患者。sNRP-1在这些患者病理生理中的确切作用有待进一步研究阐明。

{"title":"High levels of soluble neuropilin −1 in critically ill multiple trauma/surgical patients","authors":"Charikleia S. Vrettou, Chrysi Keskinidou , Alice G. Vassiliou , Georgios Poupouzas, Edison Jahaj, Vassilios Issaris, Evangelia Theodorou, Asimenia Halioti, Vassiliki Giannopoulou, Nikolaos S. Lotsios, Anastasia Kotanidou, Ioanna Dimopoulou","doi":"10.1016/j.advms.2025.02.007","DOIUrl":"10.1016/j.advms.2025.02.007","url":null,"abstract":"<div><h3>Purpose</h3><div>Critically ill trauma/surgical patients may experience excessive inflammation, immune and coagulation dysregulation, leading to multiple organ failure (MOF), carrying high mortality rates. Neuropilin-1 (NRP-1) and its soluble isoform (sNRP-1) are implicated in immune response regulation, inflammation, and vascular permeability. This study aimed to investigate the possible role of sNRP-1 in trauma/surgical patients in the intensive care unit (ICU).</div></div><div><h3>Patients and methods</h3><div>This prospective observational study was conducted in a 31-bed ICU and included 81 patients, 43 of whom were trauma/surgical patients and 38 of whom were matched medical patients, comprising the control group. sNRP-1, interleukin (IL)-6, IL-8, and IL-10 levels were measured on admission to the ICU (within 48 h).</div></div><div><h3>Results</h3><div>Trauma/surgical patients had significantly higher sNRP-1 (p = 0.027), IL-6, IL-8, and IL-10 levels (p < 0.05) compared to medical patients. In the entire cohort, sNRP-1 correlated positively with the international normalized ratio (INR) (p = 0.017), the activated partial thromboplastin time (p = 0.026), fibrinogen (p = 0.027), alanine aminotransferase (p = 0.024), and C-reactive protein (p = 0.004). Moreover, sNRP-1 correlated negatively with total protein (p = 0.035), albumin (p = 0.005), and platelets (p = 0.033).</div></div><div><h3>Conclusion</h3><div>sNRP-1 levels were elevated in critically ill trauma/surgical patients compared to matched medical ICU patients. Further research is needed to elucidate the exact role of sNRP-1 in these patients' pathophysiology.</div></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"70 1","pages":"Pages 191-196"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0