K. Spiteri, J. Xerri de Caro, K. England, N. Calleja, Lee Smith, K. Grafton, D. Broom
(1) Objectives: The study aimed to examine data from Malta’s Health Interview Survey (HIS) to assess differences between persons in employment and those retired, across different time periods. (2) Methods: A repeat cross-sectional design was adopted. Data that were collected over a period of 12 years included three cross-sectional HIS waves (2002, 2008 and 2014). Data were analysed cross-sectionally and longitudinally using multilevel analysis. (3) Results: In total, 4690 participants between the ages of 50 and 74 years provided data on physical activity (PA). A statistical difference was found between those employed and retired, with the latter undertaking less PA MET min per week in 2002 and 2008. There was no difference in 2014. When adjusting for covariates, people in employment carried out less PA MET min per week (OR-0.16–−0.02) compared to retired individuals. Using multilevel modelling, this study shows that individual factors such BMI and long-standing illness are predictors of PA behaviour as opposed to time trends. (4) Conclusion: Retirement can increase PA measured in MET minutes per week. Individual factors such as BMI, long-standing health problems and self-rated health could be causing the higher levels seen in the employed population during the studied period.
{"title":"Physical Activity Behaviour in 50- to 74-Year-Olds: Differences between Employed and Retired Individuals","authors":"K. Spiteri, J. Xerri de Caro, K. England, N. Calleja, Lee Smith, K. Grafton, D. Broom","doi":"10.3390/jal1010003","DOIUrl":"https://doi.org/10.3390/jal1010003","url":null,"abstract":"(1) Objectives: The study aimed to examine data from Malta’s Health Interview Survey (HIS) to assess differences between persons in employment and those retired, across different time periods. (2) Methods: A repeat cross-sectional design was adopted. Data that were collected over a period of 12 years included three cross-sectional HIS waves (2002, 2008 and 2014). Data were analysed cross-sectionally and longitudinally using multilevel analysis. (3) Results: In total, 4690 participants between the ages of 50 and 74 years provided data on physical activity (PA). A statistical difference was found between those employed and retired, with the latter undertaking less PA MET min per week in 2002 and 2008. There was no difference in 2014. When adjusting for covariates, people in employment carried out less PA MET min per week (OR-0.16–−0.02) compared to retired individuals. Using multilevel modelling, this study shows that individual factors such BMI and long-standing illness are predictors of PA behaviour as opposed to time trends. (4) Conclusion: Retirement can increase PA measured in MET minutes per week. Individual factors such as BMI, long-standing health problems and self-rated health could be causing the higher levels seen in the employed population during the studied period.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44179589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previous studies pointed out that the outbreak of the coronavirus disease 2019 (COVID-19) had a lesser effect on elderly people compared to their younger counterparts. However, a limited number of studies have analyzed the effects of COVID-19 on the psychological aspects of the elderly using longitudinal data. Therefore, the main objective of our study was to clarify the changes in self-rated overall daily life satisfaction among community dwelling elderly in Japan during the COVID-19 pandemic. We used the longitudinal data of 5176 individuals aged 15 years and older from the first and second internet surveys on “Changes in Daily Life Awareness and Behavior under the Influence of the New Coronavirus Infection” conducted by the Cabinet Office of Japan. The estimation result of the mixed-effects model indicated that elderly people were more adversely affected by the first wave of the pandemic (May 2020) compared to their younger counterparts. However, by the beginning of the third wave (December 2020), they had largely recovered to the same level as that of before the COVID-19 pandemic, which suggested that the elderly managed to cope with psychological distress to some extent during the prolonged COVID-19 pandemic.
{"title":"Changes in Daily Life Satisfaction among Community Dwelling Elderly during the COVID-19 Pandemic in Japan","authors":"Akira Ishida, Emiko Ishida","doi":"10.3390/jal1010002","DOIUrl":"https://doi.org/10.3390/jal1010002","url":null,"abstract":"Previous studies pointed out that the outbreak of the coronavirus disease 2019 (COVID-19) had a lesser effect on elderly people compared to their younger counterparts. However, a limited number of studies have analyzed the effects of COVID-19 on the psychological aspects of the elderly using longitudinal data. Therefore, the main objective of our study was to clarify the changes in self-rated overall daily life satisfaction among community dwelling elderly in Japan during the COVID-19 pandemic. We used the longitudinal data of 5176 individuals aged 15 years and older from the first and second internet surveys on “Changes in Daily Life Awareness and Behavior under the Influence of the New Coronavirus Infection” conducted by the Cabinet Office of Japan. The estimation result of the mixed-effects model indicated that elderly people were more adversely affected by the first wave of the pandemic (May 2020) compared to their younger counterparts. However, by the beginning of the third wave (December 2020), they had largely recovered to the same level as that of before the COVID-19 pandemic, which suggested that the elderly managed to cope with psychological distress to some extent during the prolonged COVID-19 pandemic.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44252614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-03DOI: 10.47855/jal9020-2021-2-4
A. Bozhkov, Ievgeniy Ivanov, E. Klimova, N. Kurguzova, А. Bozhkov, A. Goltvyanskiy, Y. Nikitchenko
Abstract: the content of lipid hydroperoxides in the serum and liver mitochondria in animals in the late stages of ontogenesis (12 and 33 months old, Wistar male rats) was investigated. The possible effect of the food additive (“mix factor”) on these parameters in 33 months old animals, if they received this supplement from 22 months age daily throughout life in a dose of 0.05 - 0.06 ml / 100 g of body weight was determined. Moreover, the lifespan of animals was determined if they started taking a mix – factor from 22 months and from 30.5 months age. The influence of the mix – factor on the ability of old animals to perform work was determined in a separate series of experiments. It was shown that from 22 to 33 months the content of lipid hydroperoxides in mitochondria and serum increased by 23% and 41%, respectively. The activity of glutathione peroxidase in the serum, mitochondria and erythrocytes decreased, and the activity of glutathione reductase decreased only in the post-mitochondrial fraction of the liver. At the same time, malate– isocitrate dehydrogenase and 6-phosphate dehydrogenase remained unchanged in 33 months old animals compared with 12 months old animals. If animals from 22 months age received a mix factor with drinking water in a dose of 0.05-0.06 mg / 100 g of body weight every day until the end of life, the content of lipid hydroperoxides and the activity of glutathione peroxidase and glutathione reductase of 33 months old animals did not differ from 12 months old animals. The survival curve in animals receiving the mix factor was shifted to the right from 25 to 28 months of age compared with the survival curve of control animals. If animals began to receive the mix – factor at a very old age (from 30.5 months age) until the end of life, their lifespan was longer than that of the control animals. The last ones lived to 41 months, while the animals of the control group lived to 36 months. At the same time, the mix – factor increased the ability of old animals to do work in the test “running in treadmill”. Key words: aging, redox-system, geroprotectors, lifespan
{"title":"The “Mix-Factor” is involved in the regulation of the organism's redox systems in the late stages of ontogenesis and affects the lifespan of animals","authors":"A. Bozhkov, Ievgeniy Ivanov, E. Klimova, N. Kurguzova, А. Bozhkov, A. Goltvyanskiy, Y. Nikitchenko","doi":"10.47855/jal9020-2021-2-4","DOIUrl":"https://doi.org/10.47855/jal9020-2021-2-4","url":null,"abstract":"Abstract: the content of lipid hydroperoxides in the serum and liver mitochondria in animals in the late stages of ontogenesis (12 and 33 months old, Wistar male rats) was investigated. The possible effect of the food additive (“mix factor”) on these parameters in 33 months old animals, if they received this supplement from 22 months age daily throughout life in a dose of 0.05 - 0.06 ml / 100 g of body weight was determined. Moreover, the lifespan of animals was determined if they started taking a mix – factor from 22 months and from 30.5 months age. The influence of the mix – factor on the ability of old animals to perform work was determined in a separate series of experiments. It was shown that from 22 to 33 months the content of lipid hydroperoxides in mitochondria and serum increased by 23% and 41%, respectively. The activity of glutathione peroxidase in the serum, mitochondria and erythrocytes decreased, and the activity of glutathione reductase decreased only in the post-mitochondrial fraction of the liver. At the same time, malate– isocitrate dehydrogenase and 6-phosphate dehydrogenase remained unchanged in 33 months old animals compared with 12 months old animals. If animals from 22 months age received a mix factor with drinking water in a dose of 0.05-0.06 mg / 100 g of body weight every day until the end of life, the content of lipid hydroperoxides and the activity of glutathione peroxidase and glutathione reductase of 33 months old animals did not differ from 12 months old animals. The survival curve in animals receiving the mix factor was shifted to the right from 25 to 28 months of age compared with the survival curve of control animals. If animals began to receive the mix – factor at a very old age (from 30.5 months age) until the end of life, their lifespan was longer than that of the control animals. The last ones lived to 41 months, while the animals of the control group lived to 36 months. At the same time, the mix – factor increased the ability of old animals to do work in the test “running in treadmill”.\u0000Key words: aging, redox-system, geroprotectors, lifespan","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86145189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-12DOI: 10.47855/JAL9020-2021-2-3
A. Pisaruk, N. Koshel, Ludmila Pysaruk, V. Shatilo
Abstract. The symptoms of post-COVID-19 syndrome (PPCS) are nonspecific and similar to those signs of aging. Therefore, it was suggested that those who have recovered from COVID-19 have accelerating the aging of the body. The aim of this work was to assess the influence of COVID-19 on the frequency of signs of aging. To collect the data, there was used a developed questionnaire, which included 17 signs of aging. There were received the answers from 306 people at the age from 30 to 70 years old. Among them, 98 people have had COVID-19. The average age of the people in the post-COVID-19 and COVID-19-free groups was 51,3 ± 1,65 and 50,4 ± 1,17, respectively (p> 0,05). The frequency of 14 signs of aging was significantly (p <0,01) higher among post-COVID-19 people. Particularly significant differences between post-COVID-19 and COVID-19-free were in the group of people under the age of 50 years old. The data, received by us, allowed to develop a computational procedure for diagnosing of PPCS. The task of attributing of the surveyed people to the post-COVID-19 and COVID-19-free group in accordance with the presence of certain symptoms was solved with the help of the Bayesian method in Gubler's modification, multiple logistic regression and neural network analysis. The developed diagnostic procedures can be used for the identification of the people with a high probability of the developing of PPCS. Keywords: rate of aging, post-COVID-19 syndrome, questionnaire
{"title":"Impact of COVID-19 on the signs of human ageing","authors":"A. Pisaruk, N. Koshel, Ludmila Pysaruk, V. Shatilo","doi":"10.47855/JAL9020-2021-2-3","DOIUrl":"https://doi.org/10.47855/JAL9020-2021-2-3","url":null,"abstract":"Abstract. The symptoms of post-COVID-19 syndrome (PPCS) are nonspecific and similar to those signs of aging. Therefore, it was suggested that those who have recovered from COVID-19 have accelerating the aging of the body. The aim of this work was to assess the influence of COVID-19 on the frequency of signs of aging. To collect the data, there was used a developed questionnaire, which included 17 signs of aging. There were received the answers from 306 people at the age from 30 to 70 years old. Among them, 98 people have had COVID-19. The average age of the people in the post-COVID-19 and COVID-19-free groups was 51,3 ± 1,65 and 50,4 ± 1,17, respectively (p> 0,05). The frequency of 14 signs of aging was significantly (p <0,01) higher among post-COVID-19 people. Particularly significant differences between post-COVID-19 and COVID-19-free were in the group of people under the age of 50 years old. The data, received by us, allowed to develop a computational procedure for diagnosing of PPCS. The task of attributing of the surveyed people to the post-COVID-19 and COVID-19-free group in accordance with the presence of certain symptoms was solved with the help of the Bayesian method in Gubler's modification, multiple logistic regression and neural network analysis. The developed diagnostic procedures can be used for the identification of the people with a high probability of the developing of PPCS.\u0000Keywords: rate of aging, post-COVID-19 syndrome, questionnaire","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89061695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.47855/JAL9020-2021-2-2
V. Bezrukov, Liana Kuprush, N. Sykalo, T. Panteleymonova, L. Sharabura, V. Olar
Abstract. Pathology of the cardiovascular system occupies a major place in the structure of diseases of the elderly and old patients. Metabolic disturbances are very important in ischemic damages of myocardium in the elderly and old people. So, drugі with metabolic mechanism of action is very ppromising in the treatment of elderly patients with cardiovascular diseases. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism of cardiomyocytes, improve blood supply to the myocardium, increase its contractile function. The effect of ATP-molsidomine combination on myocardial contractility in different age animals was stuiesy in vitro experiments. The experiments on the isolated hearts from adult and old rats have shown that combined use of ATP and molsidomine did not significantly affect the contractility of the isolated hearts of adult rats under different perfusion regimes. In old rats, the use of ATP-molsidomine combination had a positive effect on the contractile function of the myocardium under the influence of damaging factors (ischemia, reperfusion): prevented a decrease of left ventricular developing pressure and its first derivative (velocity of pressure rise and velocity of pressure decline) and accelerated its growth during reperfusion. Co-administration of ATP and molsidomine during ischemia had a positive effect on the heart rhythm and restored heart rate at the reperfusion period in adult and old rats. The results of the study indicate a positive effect of the ATP-molsidomine combination on the myocardial contractility in old rats. Combined use of ATP and molsidomine exerted a favourable influence on the heart rhythm under damaging factors both in the adult and old animals. Key words: ATP; molsidomine; isolated rat heart; myocardial contractility; ageing
{"title":"Effect of ATP and molsidomine combination on contractile function of isolated adult and old rat hearts during adequate coronary perfusion, at ischemia and reperfusion","authors":"V. Bezrukov, Liana Kuprush, N. Sykalo, T. Panteleymonova, L. Sharabura, V. Olar","doi":"10.47855/JAL9020-2021-2-2","DOIUrl":"https://doi.org/10.47855/JAL9020-2021-2-2","url":null,"abstract":"Abstract. Pathology of the cardiovascular system occupies a major place in the structure of diseases of the elderly and old patients. Metabolic disturbances are very important in ischemic damages of myocardium in the elderly and old people. So, drugі with metabolic mechanism of action is very ppromising in the treatment of elderly patients with cardiovascular diseases. The relevance of this study is determined by the feasibility of using drugs of metabolic action, which have a beneficial effect on the metabolism of cardiomyocytes, improve blood supply to the myocardium, increase its contractile function. The effect of ATP-molsidomine combination on myocardial contractility in different age animals was stuiesy in vitro experiments. The experiments on the isolated hearts from adult and old rats have shown that combined use of ATP and molsidomine did not significantly affect the contractility of the isolated hearts of adult rats under different perfusion regimes. In old rats, the use of ATP-molsidomine combination had a positive effect on the contractile function of the myocardium under the influence of damaging factors (ischemia, reperfusion): prevented a decrease of left ventricular developing pressure and its first derivative (velocity of pressure rise and velocity of pressure decline) and accelerated its growth during reperfusion. Co-administration of ATP and molsidomine during ischemia had a positive effect on the heart rhythm and restored heart rate at the reperfusion period in adult and old rats. The results of the study indicate a positive effect of the ATP-molsidomine combination on the myocardial contractility in old rats. Combined use of ATP and molsidomine exerted a favourable influence on the heart rhythm under damaging factors both in the adult and old animals.\u0000Key words: ATP; molsidomine; isolated rat heart; myocardial contractility; ageing","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87799244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-06DOI: 10.47855/jal9020-2021-2-1
A. Pisaruk
Abstract. To eliminate the shortcomings of calculating biological age by the multiple regression method, an alternative mathematical approach is proposed. This method consists in calculating the average value of the ratio of the values of the indicators of the examined person to the average population values of these indicators. Comparison of this method with the regression method on the data set of healthy people showed that it eliminates the disadvantages of the regression method, but gives a slightly lower accuracy in assessing biological age. Keywords: biological age; mathematical method
{"title":"Alternative mathematical method for calculating biological age","authors":"A. Pisaruk","doi":"10.47855/jal9020-2021-2-1","DOIUrl":"https://doi.org/10.47855/jal9020-2021-2-1","url":null,"abstract":"Abstract. To eliminate the shortcomings of calculating biological age by the multiple regression method, an alternative mathematical approach is proposed. This method consists in calculating the average value of the ratio of the values of the indicators of the examined person to the average population values of these indicators. Comparison of this method with the regression method on the data set of healthy people showed that it eliminates the disadvantages of the regression method, but gives a slightly lower accuracy in assessing biological age.\u0000Keywords: biological age; mathematical method","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77123012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-06DOI: 10.47855//jal9020-2021-2
{"title":"Issue 2 2021","authors":"","doi":"10.47855//jal9020-2021-2","DOIUrl":"https://doi.org/10.47855//jal9020-2021-2","url":null,"abstract":"","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73041043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is our pleasure to inaugurate the new open access journal, the Journal of Ageing and Longevity (JAL, ISSN 2673-9259) [...]
我们很高兴创刊新的开放获取期刊《journal of Ageing and Longevity》(日航，ISSN 2673-9259)[…]
{"title":"The Journal of Ageing and Longevity: Taking a Holistic View of the Human Healthspan","authors":"M. Tully, G. Pawelec","doi":"10.3390/JAL1010001","DOIUrl":"https://doi.org/10.3390/JAL1010001","url":null,"abstract":"It is our pleasure to inaugurate the new open access journal, the Journal of Ageing and Longevity (JAL, ISSN 2673-9259) [...]","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3390/JAL1010001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48689850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-05DOI: 10.47855/JAL9020-2021-1-2
A. Pisaruk
There was proposed аsimple method of the correction of systematic error of the equation of multiple regression while calculating biological age. The principle of this method is in the vertical transfer of points on the graph "predicted age -chronologicalage" on a diagonalline. At the same time, the distances from the points to the regression line are maintained. This correction eliminates the systematic error of the multiple regression equation and increases the accuracyof the biological age model.
{"title":"A simple method for correction of the systematic error in calculating biological age by the multiple regression equation","authors":"A. Pisaruk","doi":"10.47855/JAL9020-2021-1-2","DOIUrl":"https://doi.org/10.47855/JAL9020-2021-1-2","url":null,"abstract":"There was proposed аsimple method of the correction of systematic error of the equation of multiple regression while calculating biological age. The principle of this method is in the vertical transfer of points on the graph \"predicted age -chronologicalage\" on a diagonalline. At the same time, the distances from the points to the regression line are maintained. This correction eliminates the systematic error of the multiple regression equation and increases the accuracyof the biological age model.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"34 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73789179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-03DOI: 10.47855//jal9020-2020-2-5
A. Pisaruk, N. Koshel, L. Mekhova, O. Zabuga, S. Ivanov
In this study we have applied the different doses of curcumin at the larval stages of a fruitfly Drosophila melanogaster and subsequently ivestigated its effect on the developmental duration and life expectancy of imago. It has been shown a 2-day delay in the hatching of the flies, which were developing in the medium containing 500 mM of curcumin. Exposure to curcumin significantly influenced on the average and maximum lifespan (ALS and MLS respectively) of all Drosofila in the study: ALS – F=13.01, p<0.001 for males and F=14.3, p<0.001 for females; MLS – F=35.9, p<0.001 for males and F=16.7, p <0.001 for females. Thus, the ALS in the males, which at the larval stage were kept in the medium containing 125 mM, 250 mM and 500 mM of curcumin, was significantly higher (p<0.001) comparing to the control. In females, such kind of significant increase in ALS has been shown at a dose of 500 mM of curcumin (p<0.001) in the medium during the developmental stage comparing to the control. In other words, the ALS of the imago has increased in correlation to the increase in the dose of curcumin applied at the developmental stage in males by 9%, 16%, 13%, and 23% and in females by 0%, 1%, 3%, 16% respectively. There has been also shown the sharp raise in MLS in both males and females, which at the larval stage were kept in the medium containing more than 125 mM of curcumin. To sum up we can assume that in this study consumption of curcumin at the larval stage of fruit flies significantly increased the developmental duration and life span of adult Drosophila, and this may demonstrate the effect of curcumin on the epigenetic programming of pace of life. Keywords: Development; Life span; Curcumin; Drosophila
{"title":"Influense of curcumin on lifespan if it is applied at the larval stage of drosophila melanogaster","authors":"A. Pisaruk, N. Koshel, L. Mekhova, O. Zabuga, S. Ivanov","doi":"10.47855//jal9020-2020-2-5","DOIUrl":"https://doi.org/10.47855//jal9020-2020-2-5","url":null,"abstract":"In this study we have applied the different doses of curcumin at the larval stages of a fruitfly Drosophila melanogaster and subsequently ivestigated its effect on the developmental duration and life expectancy of imago. It has been shown a 2-day delay in the hatching of the flies, which were developing in the medium containing 500 mM of curcumin. Exposure to curcumin significantly influenced on the average and maximum lifespan (ALS and MLS respectively) of all Drosofila in the study: ALS – F=13.01, p<0.001 for males and F=14.3, p<0.001 for females; MLS – F=35.9, p<0.001 for males and F=16.7, p <0.001 for females. Thus, the ALS in the males, which at the larval stage were kept in the medium containing 125 mM, 250 mM and 500 mM of curcumin, was significantly higher (p<0.001) comparing to the control. In females, such kind of significant increase in ALS has been shown at a dose of 500 mM of curcumin (p<0.001) in the medium during the developmental stage comparing to the control. In other words, the ALS of the imago has increased in correlation to the increase in the dose of curcumin applied at the developmental stage in males by 9%, 16%, 13%, and 23% and in females by 0%, 1%, 3%, 16% respectively. There has been also shown the sharp raise in MLS in both males and females, which at the larval stage were kept in the medium containing more than 125 mM of curcumin. To sum up we can assume that in this study consumption of curcumin at the larval stage of fruit flies significantly increased the developmental duration and life span of adult Drosophila, and this may demonstrate the effect of curcumin on the epigenetic programming of pace of life.\u0000Keywords: Development; Life span; Curcumin; Drosophila","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84863839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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