Pub Date : 2016-05-29DOI: 10.4172/2167-0897.1000223
Amirmohammad Armanian, M. Nazem, Nima Salehimehr, B. Nekooie
Introduction: Mesenchymal hamartoma of liver (MHL) is the second most common benign liver tumor in children. This tumor typically presents as a large benign cystic mass, solid or mix in children less than three years. Prenatally, it may grow quickly to an abnormal size that may lead to death or hydrops. Prenatal suspicion arises by increasing maternal serum α-FP or HCG and polyhydroamnious and can usually identify the case in the last trimester of pregnancy by ultrasound. Case presentation: The patient was a sick 19 day old baby boy. The patient was admitted to the hospital due to the poor feeding, restlessness and nausea. On physical examination, a mass was found on the left side of the abdomen. In the MRI of the abdomen, the heterogeneous multi-lobulated mass was reported in the upper quadrant of the abdomen. Incision and drainage was done and purulent material was drained from a large abscess located in the left lobe of the liver. Finally, the pathology report showed that the infected mesengymal hamartoma of the liver. Conclusion: In neonatal period MHL can lead to emergency surgery due to fluid or puss accumulation in the cysts. Complete surgical removal is the preferred treatment and histopathological diagnosis helps.
{"title":"Mesenchymal Hamartoma of Liver in a Neonate","authors":"Amirmohammad Armanian, M. Nazem, Nima Salehimehr, B. Nekooie","doi":"10.4172/2167-0897.1000223","DOIUrl":"https://doi.org/10.4172/2167-0897.1000223","url":null,"abstract":"Introduction: Mesenchymal hamartoma of liver (MHL) is the second most common benign liver tumor in children. This tumor typically presents as a large benign cystic mass, solid or mix in children less than three years. Prenatally, it may grow quickly to an abnormal size that may lead to death or hydrops. Prenatal suspicion arises by increasing maternal serum α-FP or HCG and polyhydroamnious and can usually identify the case in the last trimester of pregnancy by ultrasound. \u0000Case presentation: The patient was a sick 19 day old baby boy. The patient was admitted to the hospital due to the poor feeding, restlessness and nausea. On physical examination, a mass was found on the left side of the abdomen. In the MRI of the abdomen, the heterogeneous multi-lobulated mass was reported in the upper quadrant of the abdomen. Incision and drainage was done and purulent material was drained from a large abscess located in the left lobe of the liver. Finally, the pathology report showed that the infected mesengymal hamartoma of the liver. \u0000Conclusion: In neonatal period MHL can lead to emergency surgery due to fluid or puss accumulation in the cysts. Complete surgical removal is the preferred treatment and histopathological diagnosis helps.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"54 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-28DOI: 10.4172/2167-0897.1000222
Mari Ohoka, Takashi Ito, Masako Kitsunezaki, K. Nomoto, Yuki Bando, M. Ishii
Commensal bacterial colonization is crucial for human health, and the early neonatal period is important for the establishment of microbial populations. However, studies on the developmental patterns of microbiota in early life, particularly in those exposed to the environment of the neonatal intensive care unit (NICU), are limited. Using a 16S ribosomal RNA polymerase chain reaction assay, this study aimed to evaluate the changes in the levels of representative microbiota in healthy term infants and infants who were admitted to the NICU during the first month of life. Compared with term infants, the NICU group showed lower levels of Bifidobacterium in the early days after birth but achieved the same levels as those of term infants after day 30 of probiotics use. In addition, we found that the presence of Staphylococcus aureus, including methicillin-resistant S. aureus, from fecal samples was not associated with disturbances in Bifidobacterium during the neonatal period. Clinical factors such as the mode of delivery, antibiotic therapy, and intubation for mechanical ventilation could change the neonatal distribution of microbiota, but the most important factor was insufficient enteral nutrition. This group, which had experienced poor general conditions and/or underwent surgery early in the neonatal period, showed are markable decrease in Bifidobacterium level at day 30. In conclusion, infants in the NICU developed similar microbiota composition as in the healthy term infants group in 1 month afterbirth; however, insufficient enteral nutrition could lead to disintegration of the microbiota distribution.
{"title":"Changes in Neonatal Microbiota Distribution Influenced by the Environment of the Neonatal Intensive Care Unit in the First Month of Life","authors":"Mari Ohoka, Takashi Ito, Masako Kitsunezaki, K. Nomoto, Yuki Bando, M. Ishii","doi":"10.4172/2167-0897.1000222","DOIUrl":"https://doi.org/10.4172/2167-0897.1000222","url":null,"abstract":"Commensal bacterial colonization is crucial for human health, and the early neonatal period is important for the establishment of microbial populations. However, studies on the developmental patterns of microbiota in early life, particularly in those exposed to the environment of the neonatal intensive care unit (NICU), are limited. Using a 16S ribosomal RNA polymerase chain reaction assay, this study aimed to evaluate the changes in the levels of representative microbiota in healthy term infants and infants who were admitted to the NICU during the first month of life. Compared with term infants, the NICU group showed lower levels of Bifidobacterium in the early days after birth but achieved the same levels as those of term infants after day 30 of probiotics use. In addition, we found that the presence of Staphylococcus aureus, including methicillin-resistant S. aureus, from fecal samples was not associated with disturbances in Bifidobacterium during the neonatal period. Clinical factors such as the mode of delivery, antibiotic therapy, and intubation for mechanical ventilation could change the neonatal distribution of microbiota, but the most important factor was insufficient enteral nutrition. This group, which had experienced poor general conditions and/or underwent surgery early in the neonatal period, showed are markable decrease in Bifidobacterium level at day 30. In conclusion, infants in the NICU developed similar microbiota composition as in the healthy term infants group in 1 month afterbirth; however, insufficient enteral nutrition could lead to disintegration of the microbiota distribution.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-23DOI: 10.4172/2167-0897.1000221
Vishal Vishnu Tewari, K. Tewari, R. Mehta
Neonates and young infants are physiologically encumbered by an inadequate hemostatic mechanism. They may also have inherited or acquired bleeding disorders which may have a catastrophic presentation with intracerebral hemorrhage. The need to reach an accurate diagnosis is paramount in order to provide accurate therapy and genetic counseling. We report two infants who presented with unprovoked life threatening massive intracerebral hemorrhage. The first infant was diagnosed and managed for congenital factor V deficiency while the second infant had Glanzmann thrombasthenia.
{"title":"Intracerebral Bleeding in Young Infants due to Rare Etiologies–A Report of two Cases","authors":"Vishal Vishnu Tewari, K. Tewari, R. Mehta","doi":"10.4172/2167-0897.1000221","DOIUrl":"https://doi.org/10.4172/2167-0897.1000221","url":null,"abstract":"Neonates and young infants are physiologically encumbered by an inadequate hemostatic mechanism. They may also have inherited or acquired bleeding disorders which may have a catastrophic presentation with intracerebral hemorrhage. The need to reach an accurate diagnosis is paramount in order to provide accurate therapy and genetic counseling. We report two infants who presented with unprovoked life threatening massive intracerebral hemorrhage. The first infant was diagnosed and managed for congenital factor V deficiency while the second infant had Glanzmann thrombasthenia.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-11DOI: 10.4172/2167-0897.1000220
S. Rahman, M. Alvin
Neonatal jaundice is seen in up to 60% of full-term infants and 80% of preterm infants during the first week of life. While it is often considered as a single clinical entity, neonatal jaundice is a physical finding associated with many possible etiologies. Jaundice is observed when the pigment bilirubin accumulates in the skin, sclera and other tissues. The importance of correctly identifying the etiology of neonatal jaundice lies in the necessity of intervening early to avoid the devastating sequelae of prolonged hyperbilirubinemia, namely bilirubin-induced neurological dysfunction (BIND), formerly kernicteruskernicterus. This manuscript provides a framework for thinking about the etiologies of neonatal jaundice with respect to type of hyperbilirubinemia (direct vs. indirect) and age of the newborn.
{"title":"Etiologies and Initial Evaluation of Neonatal Jaundice","authors":"S. Rahman, M. Alvin","doi":"10.4172/2167-0897.1000220","DOIUrl":"https://doi.org/10.4172/2167-0897.1000220","url":null,"abstract":"Neonatal jaundice is seen in up to 60% of full-term infants and 80% of preterm infants during the first week of life. While it is often considered as a single clinical entity, neonatal jaundice is a physical finding associated with many possible etiologies. Jaundice is observed when the pigment bilirubin accumulates in the skin, sclera and other tissues. The importance of correctly identifying the etiology of neonatal jaundice lies in the necessity of intervening early to avoid the devastating sequelae of prolonged hyperbilirubinemia, namely bilirubin-induced neurological dysfunction (BIND), formerly kernicteruskernicterus. This manuscript provides a framework for thinking about the etiologies of neonatal jaundice with respect to type of hyperbilirubinemia (direct vs. indirect) and age of the newborn.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-10DOI: 10.4172/2167-0897.1000219
Di, R. Silva, Monara Nunes, V. Carvalho, Fern, António Sousa, C. Ventura, S. Teixeira, V. Bastos
Zika virus infection has attracted attention of the world population, being reported in many countries / territories. The Zika virus (ZIKV; genus Flavivirus, family Flaviviridae) is a pathogen globally transmitted by emerging mosquitoes (arboviruses) of the genus Aedes spp. Recently in Brazil, the Ministry of Health confirmed the association between ZIKV and microcephaly outbreak in the Northeast, however, is not clear in the studies the pathogenesis of this process, which led us to conduct a review in databases Pubmed, Medline and Lilacs. The literature reports that the clinical manifestations of ZIKV infection are very similar to infections such as dengue and chikungunya, but usually milder and without deaths, however, the absence of specific commercial serological tests for ZIKV, makes infection a clinical challenge in diagnosis. The association of ZIKV with microcephaly is initially related to the first three months of pregnancy and leads to neurological complications that when does not result in death, causes severe functional limitations accompanied by changes in neuropsychomotor development. Because of the increased number of cases of microcephaly associated with ZIKV infection reported in Brazil, further discussions should be carried out.
{"title":"Zika Virus Infection: New Findings Related to Neurological Complications","authors":"Di, R. Silva, Monara Nunes, V. Carvalho, Fern, António Sousa, C. Ventura, S. Teixeira, V. Bastos","doi":"10.4172/2167-0897.1000219","DOIUrl":"https://doi.org/10.4172/2167-0897.1000219","url":null,"abstract":"Zika virus infection has attracted attention of the world population, being reported in many countries / territories. The Zika virus (ZIKV; genus Flavivirus, family Flaviviridae) is a pathogen globally transmitted by emerging mosquitoes (arboviruses) of the genus Aedes spp. Recently in Brazil, the Ministry of Health confirmed the association between ZIKV and microcephaly outbreak in the Northeast, however, is not clear in the studies the pathogenesis of this process, which led us to conduct a review in databases Pubmed, Medline and Lilacs. The literature reports that the clinical manifestations of ZIKV infection are very similar to infections such as dengue and chikungunya, but usually milder and without deaths, however, the absence of specific commercial serological tests for ZIKV, makes infection a clinical challenge in diagnosis. The association of ZIKV with microcephaly is initially related to the first three months of pregnancy and leads to neurological complications that when does not result in death, causes severe functional limitations accompanied by changes in neuropsychomotor development. Because of the increased number of cases of microcephaly associated with ZIKV infection reported in Brazil, further discussions should be carried out.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-07DOI: 10.4172/2167-0897.1000218
M. Saito, T. Kamoda, Daigo Kajikawa, Yayoi Miyazono, Yu Kanai, Satoshi Fujiyama, Ryoko Suzuki, Miho Takahashi Igari, Yasuhisa Urita, R. Sumazaki
Chylothorax is an abnormal condition of lymphatic fluid collection in theapleural space, and the somatostatin analog octreotide is thought to have a beneficial effect on chylothorax. However, the octreotide dosage and administration route for chylothorax have been inconsistent to date. We report three neonatal cases of persistent chylothorax successfully treated with high-dose octreotide infusion therapy (20 μg/kg/h). Case 1 was congenital chylothorax, Case 2 was secondary chylothorax after an operation for congenital diaphragmatic hernia, and Case 3 was chylothorax after a cardiac operation. In all cases, the chylothorax was not decreased by a low-dose octreotide infusion, but after a high-dose octreotide infusion, the chylothorax decreased and eventually vanished, with no side effects. Conclusion: We suggest that the dose of octreotide in neonatal chylothorax can be safely increased to a maximum of 20 µg/kg/h.
{"title":"High Dose Octreotide for the Treatment of Chylothorax in Three Neonates","authors":"M. Saito, T. Kamoda, Daigo Kajikawa, Yayoi Miyazono, Yu Kanai, Satoshi Fujiyama, Ryoko Suzuki, Miho Takahashi Igari, Yasuhisa Urita, R. Sumazaki","doi":"10.4172/2167-0897.1000218","DOIUrl":"https://doi.org/10.4172/2167-0897.1000218","url":null,"abstract":"Chylothorax is an abnormal condition of lymphatic fluid collection in theapleural space, and the somatostatin analog octreotide is thought to have a beneficial effect on chylothorax. However, the octreotide dosage and administration route for chylothorax have been inconsistent to date. We report three neonatal cases of persistent chylothorax successfully treated with high-dose octreotide infusion therapy (20 μg/kg/h). Case 1 was congenital chylothorax, Case 2 was secondary chylothorax after an operation for congenital diaphragmatic hernia, and Case 3 was chylothorax after a cardiac operation. In all cases, the chylothorax was not decreased by a low-dose octreotide infusion, but after a high-dose octreotide infusion, the chylothorax decreased and eventually vanished, with no side effects. \u0000Conclusion: We suggest that the dose of octreotide in neonatal chylothorax can be safely increased to a maximum of 20 µg/kg/h.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-05DOI: 10.4172/2167-0897.1000217
C. Mumphrey, B. Barkemeyer, Regina M. Zambrano
We report a patient with fetal hydantoin syndrome and hypoplastic left heart. Only three other cases with this association have been described. This case also highlights the importance genetic variation plays in the phenotypic variability of teratogens and the importance of good prenatal care to minimize risk of teratogenesis.
{"title":"Hypoplastic Left Heart Syndrome in a Patient with Fetal Hydantoin Syndrome","authors":"C. Mumphrey, B. Barkemeyer, Regina M. Zambrano","doi":"10.4172/2167-0897.1000217","DOIUrl":"https://doi.org/10.4172/2167-0897.1000217","url":null,"abstract":"We report a patient with fetal hydantoin syndrome and hypoplastic left heart. Only three other cases with this association have been described. This case also highlights the importance genetic variation plays in the phenotypic variability of teratogens and the importance of good prenatal care to minimize risk of teratogenesis.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-05DOI: 10.4172/2167-0897.1000216
Li Yonglin, Qiao Yanmei, Yun Zhong-ming, Zhang Xiaopu, B. Shamsi
Introduction: Respiratory distress syndrome (RDS) is the most common respiratory complication occurring in preterm newborns due to deficiency of endogenous pulmonary surfactant. Ambroxol, is a promoter of fetal lung maturity and indicated as secretolytic therapy in bronchopulmonary diseases. Klebsiella ozaenae, whose antibiotic susceptibility data is limited, is associated with ozena; a primary atrophic rhinitis (AR), RTIs, cerebral abscess, meningitis, UTIs, and is one of the leading cause of (ICU) acquired pneumonia. This case study reports the use of post-natal intravenous amroxol to treat RDS, and use of cefoperazone sulbactam to treat Klebsiella ozaenae and Pseudomonas aeruginosa. Case Presentation: A Chinese preterm, extremely low birth weight female (birth weight was 750 grams) was delivered by emergency caesarian section to a pregnancy-induced hypertensive G2P2 mother at 27 weeks’ gestational age and was admitted in the pediatric ward because of severe dyspnoea with grunting respiration, tachypnoea, cyanosis and crackles in the lung fields. A working diagnosis of RDS was made and she was placed in incubator and neonatal continuous positive airway pressure (NCPAP) was applied immediately. She was managed with ambroxol for RDS and cefoperazone sulbactam for Klebsiella ozaenae and Pseudomonas aeruginosa bacteria and was successfully treated by 3 days’ intravenous gamma globulin therapy and 10 days’ antibiotics administration. On 67th day of hospitalization, baby was discharged with a body weight of more than 2100 grams. Conclusions: The early application of NCPAP and ambroxol reduced the severity of this disease in preterm neonate and improved the clinical course of RDS. The combination of cefoperazone and sulbactam is effective against both of K. ozaenae and Pseudomonas aeruginosa bacteria.
{"title":"Use of Ambroxol and Treatment of Klebsiella Ozaenae in Extremely Low Birth Weight Preterm: Case Report and Literature Review","authors":"Li Yonglin, Qiao Yanmei, Yun Zhong-ming, Zhang Xiaopu, B. Shamsi","doi":"10.4172/2167-0897.1000216","DOIUrl":"https://doi.org/10.4172/2167-0897.1000216","url":null,"abstract":"Introduction: Respiratory distress syndrome (RDS) is the most common respiratory complication occurring in preterm newborns due to deficiency of endogenous pulmonary surfactant. Ambroxol, is a promoter of fetal lung maturity and indicated as secretolytic therapy in bronchopulmonary diseases. Klebsiella ozaenae, whose antibiotic susceptibility data is limited, is associated with ozena; a primary atrophic rhinitis (AR), RTIs, cerebral abscess, meningitis, UTIs, and is one of the leading cause of (ICU) acquired pneumonia. This case study reports the use of post-natal intravenous amroxol to treat RDS, and use of cefoperazone sulbactam to treat Klebsiella ozaenae and Pseudomonas aeruginosa. \u0000Case Presentation: A Chinese preterm, extremely low birth weight female (birth weight was 750 grams) was delivered by emergency caesarian section to a pregnancy-induced hypertensive G2P2 mother at 27 weeks’ gestational age and was admitted in the pediatric ward because of severe dyspnoea with grunting respiration, tachypnoea, cyanosis and crackles in the lung fields. A working diagnosis of RDS was made and she was placed in incubator and neonatal continuous positive airway pressure (NCPAP) was applied immediately. She was managed with ambroxol for RDS and cefoperazone sulbactam for Klebsiella ozaenae and Pseudomonas aeruginosa bacteria and was successfully treated by 3 days’ intravenous gamma globulin therapy and 10 days’ antibiotics administration. On 67th day of hospitalization, baby was discharged with a body weight of more than 2100 grams. \u0000Conclusions: The early application of NCPAP and ambroxol reduced the severity of this disease in preterm neonate and improved the clinical course of RDS. The combination of cefoperazone and sulbactam is effective against both of K. ozaenae and Pseudomonas aeruginosa bacteria.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-29DOI: 10.4172/2167-0897.1000214
R. Kadam, V. Prasad, M. Santosh
Objective: To evaluate whether preterm neonates less than 34 weeks at birth receiving rapid enteral feeding advancement at 25-30 ml/kg/day and those receiving slow enteral feeding advancement at 15-20 mL⁄kg⁄day to attain full feeding (180 ml/kg/day) are atincrease in the incidence of necrotizing enterocolitis or feed intolerance. Study design: Retrospective cohort study. Setting: Level III Neonatal Unit in Southern India Subjects: Neonates born at <34 weeks of gestational age and admitted to the NICU during study period were enrolled. Outcome: Mortality and major morbidity - NEC as per Bell staging, incidence of feedintolerance. Results: Both groups had similar baseline characteristics. The average gain in weight, length and head circumference were significantly lower in the slow feeding group as compared rapid feeding group. The mean days to reach birth weight was less in rapid feeding group; 12.43 vs. 15.46 in slow feeding group (p=0.04). It was inferred that duration of hospital stay (22.58 vs. 31.34 days) and parenteral nutrition( 8.69 vs. 11.18 days) was less in rapid feeding group as compared to slow feeding group (p= 0.04). Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Rapid feeding group does not have increased episodes of feed intolerance or NEC (5 vs. 6 cases) compared to slow feeding group. Conclusions: Our study support enteral nutrition by rapid enter
{"title":"Rapid Versus Slow Advancement of Feeds in Preterm Babies Less than 34 Weeksin Incidence of NEC and Feed Intolerance","authors":"R. Kadam, V. Prasad, M. Santosh","doi":"10.4172/2167-0897.1000214","DOIUrl":"https://doi.org/10.4172/2167-0897.1000214","url":null,"abstract":"Objective: To evaluate whether preterm neonates less than 34 weeks at birth receiving rapid enteral feeding advancement at 25-30 ml/kg/day and those receiving slow enteral feeding advancement at 15-20 mL⁄kg⁄day to attain full feeding (180 ml/kg/day) are atincrease in the incidence of necrotizing enterocolitis or feed intolerance. \u0000Study design: Retrospective cohort study. \u0000Setting: Level III Neonatal Unit in Southern India Subjects: Neonates born at <34 weeks of gestational age and admitted to the NICU during study period were enrolled. \u0000Outcome: Mortality and major morbidity - NEC as per Bell staging, incidence of feedintolerance. \u0000Results: Both groups had similar baseline characteristics. The average gain in weight, length and head circumference were significantly lower in the slow feeding group as compared rapid feeding group. The mean days to reach birth weight was less in rapid feeding group; 12.43 vs. 15.46 in slow feeding group (p=0.04). It was inferred that duration of hospital stay (22.58 vs. 31.34 days) and parenteral nutrition( 8.69 vs. 11.18 days) was less in rapid feeding group as compared to slow feeding group (p= 0.04). Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Rapid feeding group does not have increased episodes of feed intolerance or NEC (5 vs. 6 cases) compared to slow feeding group. Conclusions: Our study support enteral nutrition by rapid enter","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"2016 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-25DOI: 10.4172/2167-0897.1000213
Alonso Mata-Peréz, M. Soto-Martínez, A. Yock-Corrales
All emergency departments should be prepared to care for a critically ill infant, including having the appropriate sized equipment. The most common diagnosis in admitted neonates include respiratory infections, sepsis, congenital heart disease, bowel obstruction, hypoglycemia and seizures. Febrile neonates are at high risk for sepsis and therefore need blood, urine and CSF testing. These patients should receive empiric antibiotic therapy in hospital. There are many life-threatening illness that can affect this population and is the responsibility of the emergency physician to assess the neonate, stabilize, narrow the differential diagnosis to the most likely and begin life-sustaining treatment. Very different types of illnesses can affect a child in the neonatal period and some can give us different clinical presentation. For example, the spectrum of congenital heart disease presenting in the newborn period and early infancy ranges from benign to catastrophic. Neonatal seizures may have subtle manifestations and require a different approach than seizures in older infants and children. This is a review of the more common but life threatening pathologic conditions in the neonate if not managed adequately.
{"title":"A Practical Approach to Emergencies in the Neonatal Period","authors":"Alonso Mata-Peréz, M. Soto-Martínez, A. Yock-Corrales","doi":"10.4172/2167-0897.1000213","DOIUrl":"https://doi.org/10.4172/2167-0897.1000213","url":null,"abstract":"All emergency departments should be prepared to care for a critically ill infant, including having the appropriate sized equipment. The most common diagnosis in admitted neonates include respiratory infections, sepsis, congenital heart disease, bowel obstruction, hypoglycemia and seizures. Febrile neonates are at high risk for sepsis and therefore need blood, urine and CSF testing. These patients should receive empiric antibiotic therapy in hospital. There are many life-threatening illness that can affect this population and is the responsibility of the emergency physician to assess the neonate, stabilize, narrow the differential diagnosis to the most likely and begin life-sustaining treatment. Very different types of illnesses can affect a child in the neonatal period and some can give us different clinical presentation. For example, the spectrum of congenital heart disease presenting in the newborn period and early infancy ranges from benign to catastrophic. Neonatal seizures may have subtle manifestations and require a different approach than seizures in older infants and children. This is a review of the more common but life threatening pathologic conditions in the neonate if not managed adequately.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2016-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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