Pub Date : 2016-10-15DOI: 10.4172/2167-0897.1000233
Ksibi Imen, A. Radhouane, B. Nadia, Bennour Wafa, Cheour Meriem, Ben Amara Moez, Ayari Fayrouz, N. Benameur, A. Nadia, Néji Khaled, M. Aida, K. Samia
In neonates, renal vein thrombosis (RVT) is the second most common thrombosis.We report a case of antenatal bilateral RVT and we review the optimal therapeutic approaches. I, a male newborn was admitted in the Neonatal Intensive Care Unit of the Center for Maternity and Neonatology of Tunis (CMNT) for respiratory distress and gross hematuria. Initial laboratory work demonstrated renal impairment and Doppler renal ultrasound confirmed the diagnosis of bilateral RVT. Thrombophilia evaluation found a combined protein C and S deficiency. Thrombolysis was started with tissue plasminogen factor in association to anticoagulation with unfractionated heparin. Renal vein thrombosis in neonates is a rare condition with a high morbidity rate. Thrombotic conditions may be associated with more severe clinical presentations. Currently, there is a lack of consensus concerning the management of RVT.
{"title":"Antenatal Bilateral Renal Vein Thrombosis with Combined Protein S and C Deficiency","authors":"Ksibi Imen, A. Radhouane, B. Nadia, Bennour Wafa, Cheour Meriem, Ben Amara Moez, Ayari Fayrouz, N. Benameur, A. Nadia, Néji Khaled, M. Aida, K. Samia","doi":"10.4172/2167-0897.1000233","DOIUrl":"https://doi.org/10.4172/2167-0897.1000233","url":null,"abstract":"In neonates, renal vein thrombosis (RVT) is the second most common thrombosis.We report a case of antenatal bilateral RVT and we review the optimal therapeutic approaches. I, a male newborn was admitted in the Neonatal Intensive Care Unit of the Center for Maternity and Neonatology of Tunis (CMNT) for respiratory distress and gross hematuria. Initial laboratory work demonstrated renal impairment and Doppler renal ultrasound confirmed the diagnosis of bilateral RVT. Thrombophilia evaluation found a combined protein C and S deficiency. Thrombolysis was started with tissue plasminogen factor in association to anticoagulation with unfractionated heparin. Renal vein thrombosis in neonates is a rare condition with a high morbidity rate. Thrombotic conditions may be associated with more severe clinical presentations. Currently, there is a lack of consensus concerning the management of RVT.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-05DOI: 10.4172/2167-0897.1000232
D. Sharma, Pradeep Sharma, Sweta Shastri
Intrauterine growth restriction (IUGR) is defined as a velocity of fetal growth less than the normal fetus growth potential because of maternal, placental, fetal or genetic cause. This is an important cause of fetal and neonatal morbidity and mortality. Small for gestational age (SGA) is defined when birth weight is less than two standard deviations below the mean or less than 10th percentile for a specific population and gestational age. Usually IUGR and SGA are used interchangeably, but there exists subtle difference between the two terms. IUGR infants have both acute and long term complications and need regular follow up. This review will cover various postnatal aspects of IUGR.
{"title":"Postnatal Complications of Intrauterine Growth Restriction","authors":"D. Sharma, Pradeep Sharma, Sweta Shastri","doi":"10.4172/2167-0897.1000232","DOIUrl":"https://doi.org/10.4172/2167-0897.1000232","url":null,"abstract":"Intrauterine growth restriction (IUGR) is defined as a velocity of fetal growth less than the normal fetus growth potential because of maternal, placental, fetal or genetic cause. This is an important cause of fetal and neonatal morbidity and mortality. Small for gestational age (SGA) is defined when birth weight is less than two standard deviations below the mean or less than 10th percentile for a specific population and gestational age. Usually IUGR and SGA are used interchangeably, but there exists subtle difference between the two terms. IUGR infants have both acute and long term complications and need regular follow up. This review will cover various postnatal aspects of IUGR.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-25DOI: 10.4172/2167-0897.1000231
Ksibi Imen, A. Radhouane, J. Nádia, Cheour Meriem, H. Hafsi, Ben Amara Moez, Ayari Feirouz, B. Nadia, A. Nadia, Néji Khaled, K. Samia
Introduction: Cutis marmorata telangiectatica congenita (CMTC) is a sporadic congenital skin vascular abnormality, present at birth or shortly thereafter. The prognosis is generally good. Case report: we report the case of a preterm female newborn with cutis marmorata pattern. Conclusion: CMTC is a rare disease whose determinism remains unknown. The treatment required a multidisciplinary intervention including dermatologist, pediatricians and psychologists.
{"title":"Cutis Marmorata Telangiectatica Congenital: A Case Report","authors":"Ksibi Imen, A. Radhouane, J. Nádia, Cheour Meriem, H. Hafsi, Ben Amara Moez, Ayari Feirouz, B. Nadia, A. Nadia, Néji Khaled, K. Samia","doi":"10.4172/2167-0897.1000231","DOIUrl":"https://doi.org/10.4172/2167-0897.1000231","url":null,"abstract":"Introduction: Cutis marmorata telangiectatica congenita (CMTC) is a sporadic congenital skin vascular abnormality, present at birth or shortly thereafter. The prognosis is generally good. \u0000Case report: we report the case of a preterm female newborn with cutis marmorata pattern. \u0000Conclusion: CMTC is a rare disease whose determinism remains unknown. The treatment required a multidisciplinary intervention including dermatologist, pediatricians and psychologists.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-16DOI: 10.4172/2167-0897.1000230
M. Giampietri, P. Biver, P. Ghirri, L. Bartalena, R. Scaramuzzo, A. Guzzetta, E. Fiorentini, S. Fiori, Viviana Marchi, A. Boldrini, G. Cioni, R. Guerrini
Background: The clinical use of amplitude integrated electroencephalogram (aEEG) in the neonatal intensive care unit has largely increased. This method has been reported to have a very good predictive value for neurodevelopmental outcome in term neonates after perinatal asphyxia. Aim: The aim of this study was to assess the recovery of aEEG patterns during hypothermic treatment in full term asphyxiated neonates. Our working hypothesis is that children with aEEG recovery within 24 h of therapeutic hypothermia will have a normal development outcome (i.e., no or mild neurological impairment). Study design: We performed an observational prospective study on a group of asphyxiated patients admitted to our Neonatal Intensive Care Unit from April 2009 to April 2012. Results: 24 patients with moderate to severe perinatal asphyxia had an aEEG recorded for at least 72 h during hypotermia (at the beginning of the registration 13 patients presented moderate aEEG abnormalities and 11 severe aEEG abnormalities). Respectively 11 neonates with moderate aEEG abnormalities and 1 neonate with severe abnormalities normalized the aEEG pattern during the treatment. At the follow up 3 patients died during neonatal age, 5 babies developed cerebral palsy, 4 babies developed dyskinetic cerebral palsy and 12 babies did not develop any disability (babies with good outcome were those with normal aEEG pattern at 24 h). Conclusion: Recovery to a normal aEEG background pattern within the first 24 h of hypothermia after perinatal asphyxia predicts a normal outcome. Abnormal aEEG pattern persisting after 24 h correlates with poor outcome (death or cerebral palsy).
背景:波幅综合脑电图(aEEG)在新生儿重症监护病房的临床应用已大大增加。据报道，这种方法对围产期窒息后足月新生儿的神经发育结局有很好的预测价值。目的:本研究的目的是评估在低温治疗足月窒息新生儿aEEG模式的恢复。我们的工作假设是，治疗性低温24小时内aEEG恢复的儿童将具有正常的发育结果(即无或轻度神经损伤)。研究设计:我们对2009年4月至2012年4月入住新生儿重症监护病房的一组窒息患者进行了一项观察性前瞻性研究。结果:24例中重度围产期窒息患者在低温期间记录了至少72 h的aEEG(登记开始时13例出现中度aEEG异常，11例出现重度aEEG异常)。11例中度aEEG异常新生儿和1例重度异常新生儿在治疗期间aEEG模式正常化。随访时新生儿死亡3例，脑瘫5例，运动障碍脑瘫4例，无残疾12例(24 h aEEG模式正常的患儿预后良好)。结论:围产期窒息后低温后24 h内恢复到正常aEEG背景模式患儿预后正常。异常aEEG模式持续24小时与预后不良(死亡或脑瘫)相关。
{"title":"Recovery of aEEG Patterns at 24 Hours of Hypothermia Predicts Good Neurodevelopmental Outcome","authors":"M. Giampietri, P. Biver, P. Ghirri, L. Bartalena, R. Scaramuzzo, A. Guzzetta, E. Fiorentini, S. Fiori, Viviana Marchi, A. Boldrini, G. Cioni, R. Guerrini","doi":"10.4172/2167-0897.1000230","DOIUrl":"https://doi.org/10.4172/2167-0897.1000230","url":null,"abstract":"Background: The clinical use of amplitude integrated electroencephalogram (aEEG) in the neonatal intensive care unit has largely increased. This method has been reported to have a very good predictive value for neurodevelopmental outcome in term neonates after perinatal asphyxia. \u0000Aim: The aim of this study was to assess the recovery of aEEG patterns during hypothermic treatment in full term asphyxiated neonates. Our working hypothesis is that children with aEEG recovery within 24 h of therapeutic hypothermia will have a normal development outcome (i.e., no or mild neurological impairment). \u0000 \u0000Study design: We performed an observational prospective study on a group of asphyxiated patients admitted to our Neonatal Intensive Care Unit from April 2009 to April 2012. Results: 24 patients with moderate to severe perinatal asphyxia had an aEEG recorded for at least 72 h during hypotermia (at the beginning of the registration 13 patients presented moderate aEEG abnormalities and 11 severe aEEG abnormalities). Respectively 11 neonates with moderate aEEG abnormalities and 1 neonate with severe abnormalities normalized the aEEG pattern during the treatment. At the follow up 3 patients died during neonatal age, 5 babies developed cerebral palsy, 4 babies developed dyskinetic cerebral palsy and 12 babies did not develop any disability (babies with good outcome were those with normal aEEG pattern at 24 h). \u0000Conclusion: Recovery to a normal aEEG background pattern within the first 24 h of hypothermia after perinatal asphyxia predicts a normal outcome. Abnormal aEEG pattern persisting after 24 h correlates with poor outcome (death or cerebral palsy).","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-11DOI: 10.4172/2167-0897.1000229
Y. Ethawi
US have a promising alternative mean for quick confirmation of the ETT placement. However, small and few studies have shown that the sensitivity of this tool to accurately assess the ETT placement relative to chest XR or capnography is approximately 91-100%. The overall accuracy of this method is very interesting as it reaches 89-98% in some studies. An additional advantage of this method as suggested by some of these studies is the rapid assessment of the ETT position; this can be as quick as 17 seconds using an US curvilinear probe. Understandably, the confirmation of the ETT position was somewhat challenging in short neck patients and in those wearing cervical collars. I believe that using this method is worth looking into in the near future. Although most of the subjects of these studies were adults and children, I don't see a limitation to use this tool in neonatology, especially if the waiting time between intubation and doing confirmatory XR in some facilities is long. Based upon various small observational studies, bedside US can be used to 1. Direct visualization of the ETT in the trachea 2. Showing lung sliding 3. Diaphragmatic Excursion
{"title":"Confirming Endotracheal Tube (ETT) Position in Pediatric and Neonatology Using a Bedside Ultrasound (Us); an Emerging Tool","authors":"Y. Ethawi","doi":"10.4172/2167-0897.1000229","DOIUrl":"https://doi.org/10.4172/2167-0897.1000229","url":null,"abstract":"US have a promising alternative mean for quick confirmation of the ETT placement. However, small and few studies have shown that the sensitivity of this tool to accurately assess the ETT placement relative to chest XR or capnography is approximately 91-100%. The overall accuracy of this method is very interesting as it reaches 89-98% in some studies. An additional advantage of this method as suggested by some of these studies is the rapid assessment of the ETT position; this can be as quick as 17 seconds using an US curvilinear probe. Understandably, the confirmation of the ETT position was somewhat challenging in short neck patients and in those wearing cervical collars. I believe that using this method is worth looking into in the near future. Although most of the subjects of these studies were adults and children, I don't see a limitation to use this tool in neonatology, especially if the waiting time between intubation and doing confirmatory XR in some facilities is long. Based upon various small observational studies, bedside US can be used to \u00001. Direct visualization of the ETT in the trachea \u00002. Showing lung sliding \u00003. Diaphragmatic Excursion","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-09DOI: 10.4172/2167-0897.1000226
Priyanka Gupta, A. Upadhyay
Seizures are defined clinically as a paroxysmal alteration in neurologic function, i.e., motor, behaviour and/or autonomic function. Seizures are the most important signal of neurological disease in the neonatal period. They occur in 1-5% of the new-borns. The incidence is higher during this period than in any other period in life. It is important to treat seizures because of the potential adverse effects of seizure on respiratory function, circulation, cerebral metabolism and brain development. If aEEG is being used, termination of all electrical seizure activity should be the goal of therapy. Though mortality due to neonatal seizures has decreased from 40% to about 20% over the years, the prevalence of long term neurodevelopmental sequel has remained almost unchanged at around 30%. This signifies that the treatment of neonatal seizures is still inappropriate and there is a potential for improvement. Current guidelines are based on limited clinical data. The controversies regarding the best first line agent, second line agent, dose and duration, monitoring the drug levels still continue.
{"title":"Phenobarbitone in Neonatal Seizures: Controversies","authors":"Priyanka Gupta, A. Upadhyay","doi":"10.4172/2167-0897.1000226","DOIUrl":"https://doi.org/10.4172/2167-0897.1000226","url":null,"abstract":"Seizures are defined clinically as a paroxysmal alteration in neurologic function, i.e., motor, behaviour and/or autonomic function. Seizures are the most important signal of neurological disease in the neonatal period. They occur in 1-5% of the new-borns. The incidence is higher during this period than in any other period in life. It is important to treat seizures because of the potential adverse effects of seizure on respiratory function, circulation, cerebral metabolism and brain development. If aEEG is being used, termination of all electrical seizure activity should be the goal of therapy. Though mortality due to neonatal seizures has decreased from 40% to about 20% over the years, the prevalence of long term neurodevelopmental sequel has remained almost unchanged at around 30%. This signifies that the treatment of neonatal seizures is still inappropriate and there is a potential for improvement. Current guidelines are based on limited clinical data. The controversies regarding the best first line agent, second line agent, dose and duration, monitoring the drug levels still continue.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-09DOI: 10.4172/2167-0897.1000227
Naoko Horii
There is strong evidence about the benefits of early, exclusive and continued breastfeeding to mitigate maternal and child mortality risk and illnesses [1–4]. Breastfeeding has been globally recognized as a measurement indicator for the health outcome of populations [5]. However, a secondary analysis of the Niger 2012 demographic health survey showed that exclusivity of postpartum breastfeeding was compromised too early by prelacteal feeding: half of the interviewed women (50.3%) reported having given their child other liquids than breast milk in the first 3 days of birth [6]. The 67th World Health Assembly adopted a resolution on sustainable actions across sectors to improve health equity [7]. Community based interventions led by a non-health sector were recognized to improve neonatal health of the poorest [8]. Studies showed that early initiation of breastfeeding, a critical protective factor for neonatal survival, is impaired by socioeconomic vulnerability of mothers [9–11]. A recently published article by the author clearly revealed the importance of identifying risk factors hindering early initiation of breastfeeding for which the scientific evidence remains scarce in Sub-Saharan Africa [12].
{"title":"Is the Poverty Gap a Barrier to Early Initiation of Breastfeeding in Rural Niger","authors":"Naoko Horii","doi":"10.4172/2167-0897.1000227","DOIUrl":"https://doi.org/10.4172/2167-0897.1000227","url":null,"abstract":"There is strong evidence about the benefits of early, exclusive and continued breastfeeding to mitigate maternal and child mortality risk and illnesses [1–4]. Breastfeeding has been globally recognized as a measurement indicator for the health outcome of populations [5]. However, a secondary analysis of the Niger 2012 demographic health survey showed that exclusivity of postpartum breastfeeding was compromised too early by prelacteal feeding: half of the interviewed women (50.3%) reported having given their child other liquids than breast milk in the first 3 days of birth [6]. The 67th World Health Assembly adopted a resolution on sustainable actions across sectors to improve health equity [7]. Community based interventions led by a non-health sector were recognized to improve neonatal health of the poorest [8]. Studies showed that early initiation of breastfeeding, a critical protective factor for neonatal survival, is impaired by socioeconomic vulnerability of mothers [9–11]. A recently published article by the author clearly revealed the importance of identifying risk factors hindering early initiation of breastfeeding for which the scientific evidence remains scarce in Sub-Saharan Africa [12].","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-05DOI: 10.4172/2167-0897.1000228
Akanksha Verma, P. Dixit
Background: Breast feeding has been defines as the practice through which adequate nutrition and other nutritional requirements of the new born are being taken care of. Exclusively Breast feeding is a term used to define the process by which only breast milk is given to the new born till the first six months of life. But it has been enveloped in many layers of the factors like the Social and cultural attitudes which further affect the practice and rate of breast feeding worldwide and also in India which is considered to be one of the major reasons for the IMR and under-5 mortality rate. Methods: Cross-sectional study was conducted using a semi-structured interview schedule. A total of 256 mothers who were in their reproductive age and had delivered in the last 12 months were interviewed. Results: While studying the practice of exclusive breast-feeding among the participants it was seen that the practice of exclusive breast-feeding was were low among them, i.e., only 24.8% of the total women going for the practice of exclusive breast-feeding. On looking at the various reasons for the early cessation of exclusive breast feeding, multiple responses were seen like breast related factors included reasons like breast feeding were painful or the baby had difficulty in swallowing. Cultural belief was seen to be one of most dominant factor for the practice of giving prelacteal feed. It was seen that many factors associated with the practice of breastfeeding including psychosocial factors, maternal socio-demographic characteristics, hospital practices and environmental support, etc. Conclusion: Nutrition has been considered to be one of the basis of a healthy foundation of the future. Breast milk and breast feeding has been considered to be the best nutrition for the new born till the first six months of age. Under nutrition during first two years impairs not only the cognitive development, intelligence, strength, energy and productivity. Although breast feeding is almost universal in India the rate of early initiation of breast feeding and exclusive breast feeding are dismally low. Several f actors can be attributed to this which has a great influence on the breast feeding practices.
{"title":"Knowledge and Practices of Exclusive Breastfeeding among Women in Rural Uttar Pradesh","authors":"Akanksha Verma, P. Dixit","doi":"10.4172/2167-0897.1000228","DOIUrl":"https://doi.org/10.4172/2167-0897.1000228","url":null,"abstract":"Background: Breast feeding has been defines as the practice through which adequate nutrition and other nutritional requirements of the new born are being taken care of. Exclusively Breast feeding is a term used to define the process by which only breast milk is given to the new born till the first six months of life. But it has been enveloped in many layers of the factors like the Social and cultural attitudes which further affect the practice and rate of breast feeding worldwide and also in India which is considered to be one of the major reasons for the IMR and under-5 mortality rate. \u0000Methods: Cross-sectional study was conducted using a semi-structured interview schedule. A total of 256 mothers who were in their reproductive age and had delivered in the last 12 months were interviewed. Results: While studying the practice of exclusive breast-feeding among the participants it was seen that the practice of exclusive breast-feeding was were low among them, i.e., only 24.8% of the total women going for the practice of exclusive breast-feeding. On looking at the various reasons for the early cessation of exclusive breast feeding, multiple responses were seen like breast related factors included reasons like breast feeding were painful or the baby had difficulty in swallowing. Cultural belief was seen to be one of most dominant factor for the practice of giving prelacteal feed. It was seen that many factors associated with the practice of breastfeeding including psychosocial factors, maternal socio-demographic characteristics, hospital practices and environmental support, etc. \u0000Conclusion: Nutrition has been considered to be one of the basis of a healthy foundation of the future. Breast milk and breast feeding has been considered to be the best nutrition for the new born till the first six months of age. Under nutrition during first two years impairs not only the cognitive development, intelligence, strength, energy and productivity. Although breast feeding is almost universal in India the rate of early initiation of breast feeding and exclusive breast feeding are dismally low. Several f actors can be attributed to this which has a great influence on the breast feeding practices.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-27DOI: 10.4172/2167-0897.1000225
Rafaela Wagner, Camila Vieira Bellettini, B. Márcia, Eira, Eduardo Maranhão Gubert, M. Santos
Mevalonate kinase (MK) deficiency is an auto inflammatory autosomal recessive disorder caused by a mutation in the gene encoding MK, an essential enzyme in the biosynthesis of cholesterol and isoprenoids. The disease has a wide clinical spectrum according to enzyme residual activity, the most severe form is known as Mevalonic Aciduria (MA). The aim of this article is to report a clinical case of severe MA, with an initial manifestation of a skin rash known as blueberry muffin, most commonly associated with congenital infections or neonatal hematopoietic diseases. We report the case of a three-month boy, born to consanguineous parents, that was referred to our service for assessment of malnutrition, vomiting, fever, jaundice and hepatosplenomegaly. At birth, he presented a purpuric rash suggestive of Blueberry Muffin Baby Syndrome. A thorough investigation revealed increased excretion of urinary mevalonic acid and a single mutation in homozygosis in exon 10 of the MK gene, which confirmed the diagnosis of MA. Our clinical case brings out the first report that associates blueberry muffin rash and MA.
{"title":"Mevalonic Aciduria as a Differential Diagnosis of Blueberry Muffin Baby","authors":"Rafaela Wagner, Camila Vieira Bellettini, B. Márcia, Eira, Eduardo Maranhão Gubert, M. Santos","doi":"10.4172/2167-0897.1000225","DOIUrl":"https://doi.org/10.4172/2167-0897.1000225","url":null,"abstract":"Mevalonate kinase (MK) deficiency is an auto inflammatory autosomal recessive disorder caused by a mutation in the gene encoding MK, an essential enzyme in the biosynthesis of cholesterol and isoprenoids. The disease has a wide clinical spectrum according to enzyme residual activity, the most severe form is known as Mevalonic Aciduria (MA). The aim of this article is to report a clinical case of severe MA, with an initial manifestation of a skin rash known as blueberry muffin, most commonly associated with congenital infections or neonatal hematopoietic diseases. We report the case of a three-month boy, born to consanguineous parents, that was referred to our service for assessment of malnutrition, vomiting, fever, jaundice and hepatosplenomegaly. At birth, he presented a purpuric rash suggestive of Blueberry Muffin Baby Syndrome. A thorough investigation revealed increased excretion of urinary mevalonic acid and a single mutation in homozygosis in exon 10 of the MK gene, which confirmed the diagnosis of MA. Our clinical case brings out the first report that associates blueberry muffin rash and MA.","PeriodicalId":73850,"journal":{"name":"Journal of neonatal biology","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-0897.1000225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-27DOI: 10.4172/2167-0897.1000224
H. Moussa, S. Nasab, S. Blackwell, B. Sibai
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