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How do GLP-1 receptor agonists influence the progression of shoulder pathology? A matched cohort analysis GLP-1受体激动剂如何影响肩关节病理进展?配对队列分析
Q4 Medicine Pub Date : 2025-10-31 DOI: 10.1016/j.xrrt.2025.100613
William R. Davis BS , Nicholas C. Bank MD , Bradley J. Lauck BA , Robert A. Creighton MD , R. Justin Mistovich MD, MBA

Background

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used for managing type 2 diabetes mellitus (T2DM) and obesity due to their proven metabolic benefits. However, their impact on musculoskeletal conditions, particularly in non-weight-bearing joints such as the shoulder joint, remains unclear. This study aimed to determine whether GLP-1RA use was associated with the development of shoulder pathologies (glenohumeral osteoarthritis, adhesive capsulitis, atraumatic rotator cuff tears, and shoulder fractures) over a 5-year period.

Methods

A retrospective cohort study was performed using the TriNetX research database. Adult patients prescribed GLP-1RAs between 2017 and 2019 were identified and stratified into 3 cohorts based on obesity (body mass index ≥30) and T2DM status: (1) obese T2DM, (2) nonobese T2DM, and (3) nonobese non-T2DM. Within each group, GLP-1RA users were 1:1 propensity score matched to nonusers. Primary outcomes (glenohumeral osteoarthritis, adhesive capsulitis, atraumatic rotator cuff tears, and shoulder fractures) were evaluated over a 5-year period, and secondary outcomes (hemoglobin A1c and body mass index) were assessed over a 2-year period. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to compare incidence between GLP-1RA users and nonusers.

Results

At 5-year follow-up, GLP-1RA use was associated with higher incidence rates of glenohumeral osteoarthritis, adhesive capsulitis, and atraumatic rotator cuff tears across all subgroups as compared to nonusers. The highest increased risk was observed for adhesive capsulitis, particularly in the obese nondiabetic subgroup (HR: 2.465; 95% CI [3.173-1.916]). Shoulder fracture incidence was lower among GLP-1RA users with both obesity and T2DM (HR: 0.903; 95% CI [0.827-0.987]) but did not differ significantly in patients with obesity without T2DM or in nonobese patients with diabetes.

Conclusions

GLP-1RA therapy was associated with an increased incidence of certain shoulder pathologies, most notably adhesive capsulitis, suggesting GLP-1RAs may have adverse musculoskeletal effects in the shoulder joint. These findings highlight the need for future prospective studies to confirm these associations.
胰高血糖素样肽-1受体激动剂(GLP-1RAs)越来越多地用于治疗2型糖尿病(T2DM)和肥胖,因为它们具有已证实的代谢益处。然而,它们对肌肉骨骼状况的影响,特别是对非负重关节(如肩关节)的影响尚不清楚。本研究旨在确定GLP-1RA的使用是否与肩关节病变(肩关节骨关节炎、粘连性囊炎、非外伤性肩袖撕裂和肩关节骨折)的发展相关。方法采用TriNetX研究数据库进行回顾性队列研究。2017年至2019年期间服用GLP-1RAs的成年患者被确定并根据肥胖(体重指数≥30)和T2DM状态分为3组:(1)肥胖型T2DM,(2)非肥胖型T2DM,(3)非肥胖型非T2DM。在每一组中,GLP-1RA使用者与非使用者的倾向评分为1:1。主要结局(肩关节骨关节炎、粘连性囊炎、非外伤性肩袖撕裂和肩部骨折)在5年内进行评估,次要结局(血红蛋白A1c和体重指数)在2年内进行评估。使用95%置信区间(ci)的风险比(hr)比较GLP-1RA使用者和非使用者之间的发病率。结果在5年的随访中,与未使用GLP-1RA相比,所有亚组中GLP-1RA的使用与肩关节骨关节炎、粘连性囊炎和非外伤性肩袖撕裂的发生率较高相关。粘连性囊炎的风险增加最高,尤其是肥胖非糖尿病亚组(HR: 2.465; 95% CI[3.173-1.916])。肩关节骨折的发生率在同时患有肥胖和T2DM的GLP-1RA使用者中较低(HR: 0.903; 95% CI[0.827-0.987]),但在没有T2DM的肥胖患者和非肥胖的糖尿病患者中无显著差异。结论:glp - 1ra治疗与某些肩部病变的发生率增加有关,最明显的是粘连性囊炎,这表明GLP-1RAs可能对肩关节的肌肉骨骼有不良影响。这些发现强调了未来前瞻性研究证实这些关联的必要性。
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引用次数: 0
Anterior shoulder dislocation with coracoid fracture treated with Bristow procedure: a case report and literature review 布里斯托手术治疗前肩脱位合并喙突骨折1例并文献复习
Q4 Medicine Pub Date : 2025-10-30 DOI: 10.1016/j.xrrt.2025.100607
Fotios Panagopoulos MD, Vasileios Giannatos MD, Panagiotis Antzoulas MD, Michail Kroustalakis MD, Konstantinos Koutas MD, Zinon Kokkalis MD
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引用次数: 0
All-cause cancellation of primary total shoulder arthroplasty at a single institution: prevalence, reasons and risk factors 单一机构原发性全肩关节置换术的全因取消:患病率、原因和危险因素
Q4 Medicine Pub Date : 2025-10-30 DOI: 10.1016/j.xrrt.2025.100609
Vishal Shankar BA , Cameron Smith BA, MPH , Savino Stallone BS , Yungtai Lo PhD , Elilary Montilla MD , Konrad I. Gruson MD

Background

Cancellation of elective total shoulder arthroplasty (TSA), particularly those occurring on or just before the surgical date, results in disruption to the surgeon's schedule and operating room flow with resulting negative financial implications. The prevalence and risk factors for all-cause cancellations remain poorly defined.

Methods

A retrospective review of an institutional database was performed to identify all-cause cancellations of primary TSA from January 2016 through December 2024. Patient demographics and surgical data, including age, insurance type, distance from home-to-clinic, socioeconomic status based on the Area Deprivation Index and arthroplasty type was tabulated. The time from booking and cancellation to planned arthroplasty, and reason for cancellation, in addition to whether the surgery was rescheduled and ultimately performed, was documented.

Results

There were 489 total cases booked during the study period by a single surgeon, of which 127 (25.9%) were canceled prior to the surgical date. There were 225 anatomic and 264 reverse TSAs, and 318 (65%) patients were female. Of the cancellations, 50 (39.4%) rescheduled and underwent TSA at a median of 98 days (interquartile range 47,238) later. A longer time between booking and planned surgery (OR 1.01, 95% confidence interval (CI) 1.001-1.02, P = .012) and presentation to the emergency department for any reason within 1 year prior to planned surgery were significantly associated with cancellation. Among cancellations, patient-driven cancellations (OR 3.74, 95% CI 1.45-9.60, P = .008) were associated with a significantly higher likelihood of not rescheduling surgery, whereas being married was associated with a decreased risk for not rescheduling (OR 0.36, 95% CI 0.15-0.84, P = .018).

Discussion

Identification of the factors associated with cancellation of elective TSA may serve as the basis for developing preoperative interventions aimed specifically at those more likely to cancel.
背景:选择性全肩关节置换术(TSA)的取消,特别是在手术当日或手术前取消,会导致外科医生的日程安排和手术室流程中断,并产生负面的经济影响。全因取消的患病率和危险因素仍然不明确。方法回顾性分析2016年1月至2024年12月间机构数据库中原发性TSA的全因取消。患者人口统计数据和手术数据,包括年龄、保险类型、从家到诊所的距离、基于区域剥夺指数的社会经济状况和关节置换类型。从预约和取消到计划的关节置换术的时间,取消的原因,以及手术是否重新安排并最终进行,都被记录下来。结果研究期间单个外科医生共预约489例,其中术前取消127例(25.9%)。解剖性tsa 225例,反向tsa 264例,女性318例(65%)。在取消的病例中,50例(39.4%)重新安排并在中位数为98天(四分位数间距为47,238)后接受了TSA。预约和计划手术之间的时间间隔较长(OR 1.01, 95%可信区间(CI) 1.001-1.02, P = 0.012)以及在计划手术前1年内因任何原因到急诊科就诊与取消手术显著相关。在取消手术中,患者驱动的取消手术(OR 3.74, 95% CI 1.45-9.60, P = 0.008)与不重新安排手术的可能性显著增加相关,而已婚患者与不重新安排手术的风险降低相关(OR 0.36, 95% CI 0.15-0.84, P = 0.018)。讨论确定与取消选择性TSA相关的因素可以作为制定术前干预措施的基础,特别是针对那些更有可能取消的患者。
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引用次数: 0
Treatment of isolated greater tuberosity fractures: a scoping review 孤立性大结节骨折的治疗:范围回顾
Q4 Medicine Pub Date : 2025-10-30 DOI: 10.1016/j.xrrt.2025.100611
Mathilde Abildgaard MD , David Karimi MD , Kristine Rask Andreasen MD , Dennis Karimi MD, PhD , Tazio Maleitzke MD , Per Hölmich MD, DMSc , Adam Witten MD, PhD

Background

There are no evidence-based guidelines to support the management of isolated greater tuberosity fractures. While the choice between nonoperative and operative treatment is generally based on the degree of fracture displacement, the definition of an acceptable displacement continues to be debated. Consequently, the ideal management of these fractures can be a therapeutic challenge. The objective of this study was to create an overview of the literature investigating the treatment of isolated greater tuberosity fractures.

Methods

A scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension guidelines for scoping reviews (PRISMA-ScR). Electronic databases MEDLINE, EMBASE, SPORTDiscus, and CINAHL were systematically searched from inception to September 29, 2024. Original studies investigating the treatment of isolated greater tuberosity fractures were eligible for inclusion. Screening of studies was independently performed by 3 reviewers. Data items were extracted using a standardized charting form. Risk of bias of the included studies was assessed by 2 independent reviewers using the Newcastle-Ottawa Quality Assessment Scale.

Results

3.788 records were identified in the search, 296 were retrieved for full-text screening, of which 59 were included. No randomized controlled trials were identified. 88% of the included studies were retrospective and 98% had a moderate or high risk of bias. Most of the included studies investigated operative treatment of displaced fractures (defined as >5 mm) in patient populations with a mean age between 40 and 60 years. Few studies investigated nonoperative treatment and treatment in young (<40 years) or elderly (>60 years) patients. Detailed fracture characteristics were not consistently reported. Accordingly, the size of the fragment was reported in 8% of the included studies, fractures were subclassified into avulsion, split or depression type in 29% of the included studies, and the direction of fragment displacement was reported in 34% of the included studies.

Conclusion

The literature regarding the treatment of isolated greater tuberosity fractures is comprised of studies with a moderate to high risk of bias and a lack of randomized controlled trials. A 5 mm fracture displacement threshold is often used to guide treatment, though it has not been validated in clinical studies. High-quality studies are needed to establish evidence-based guidelines and improve clinical decision-making.
背景:目前尚无基于证据的指南来支持孤立性大结节骨折的治疗。虽然非手术治疗和手术治疗的选择通常基于骨折移位的程度,但可接受移位的定义仍在争论中。因此,这些骨折的理想管理可能是一个治疗挑战。本研究的目的是对研究孤立性大结节骨折治疗的文献进行综述。方法根据系统评价和荟萃分析范围评价扩展指南的首选报告项目(PRISMA-ScR)进行范围评价。系统检索了MEDLINE、EMBASE、SPORTDiscus和CINAHL等电子数据库,检索时间从成立到2024年9月29日。研究孤立性大结节骨折治疗的原始研究符合纳入条件。研究筛选由3位评论者独立完成。使用标准化的图表形式提取数据项。纳入研究的偏倚风险由2名独立审稿人使用Newcastle-Ottawa质量评估量表进行评估。结果检索到3.788条记录,检索到296条进行全文筛选,其中59条被纳入。未发现随机对照试验。纳入的研究中88%是回顾性研究,98%有中度或高度偏倚风险。大多数纳入的研究调查了平均年龄在40至60岁之间的移位性骨折(定义为>;5 mm)的手术治疗。很少有研究探讨非手术治疗和年轻(40岁)或老年(60岁)患者的治疗。详细的骨折特征没有一致的报道。因此,8%的纳入研究报道了碎片的大小,29%的纳入研究将骨折细分为撕脱型、劈裂型或凹陷型,34%的纳入研究报道了碎片移位的方向。结论:文献中关于孤立性大结节骨折治疗的研究存在中等至高偏倚风险,缺乏随机对照试验。5mm骨折位移阈值通常用于指导治疗,但尚未在临床研究中得到验证。需要高质量的研究来建立循证指南和改善临床决策。
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引用次数: 0
Arthroscopic bone block using an autologous iliac crest graft and concomitant remplissage for severe bipolar bone loss in a young patient with anterior shoulder instability: a case report 关节镜下应用自体髂骨移植物进行骨阻滞并伴随复发治疗严重双相骨丢失的年轻前肩不稳患者:一例报告
Q4 Medicine Pub Date : 2025-10-29 DOI: 10.1016/j.xrrt.2025.100606
Irina Todiraş MD , Christina Lorenz MD , Markus Scheibel PD, MD , Florian Freislederer MD
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引用次数: 0
Débridement, antibiotics, and implant retention versus 2-stage revision for infected total elbow arthroplasty: a systematic review and meta-analysis 对感染的全肘关节置换术患者进行2期翻修:一项系统回顾和荟萃分析
Q4 Medicine Pub Date : 2025-10-28 DOI: 10.1016/j.xrrt.2025.100603
Ankur Khanna BS, Christopher M. Hart MD, Tristan B. Weir MD, Micah Nieboer MD, Larry J. Prokop MLIS, Jonathan D. Barlow MD, Jennifer Tangtiphaiboontana MD, Joaquin Sanchez-Sotelo MD, Mark E. Morrey MD

Background

Periprosthetic joint infection after total elbow arthroplasty (TEA) is associated with substantial morbidity and the need for revision surgery. The aim of this systematic review and meta-analysis was to summarize studies on 2-stage exchange and débridement, antibiotics, and implant retention (DAIR) to determine differences in rates of recurrent infection, risk factors for recurrent infection, noninfectious complications, and functional outcomes.

Methods

A systematic search was conducted of the MEDLINE, EMBASE, Cochrane, Scopus, and Web of Science databases in March 2024 to identify studies on infected TEAs treated with either 2-stage revision surgery or DAIR. Exclusion criteria included duplicate publications, review articles, and studies with a mean follow-up of less than 1 year. Fourteen studies were included in the final analysis. Data abstracted included demographics, treatment modalities, bacterial speciation, rates of recurrent infection, and functional outcomes (range of motion data and Mayo Elbow Performance Score.

Results

Two hundred ninety infected TEAs were included across all 14 studies, 131 treated with DAIR and 159 treated with 2-stage exchange. The overall pooled random-effects rate of recurrent infection was 34% (95% confidence interval: 21%-47%). The rate of recurrent infection was significantly lower following 2-stage exchange compared to DAIR (18% vs. 51%, P = .004). The overall pooled rate of noninfectious complications was 34% (95% confidence interval: 22%-46%). With the numbers available, the rate of noninfectious complications between 2-stage exchange and DAIR was smaller for 2-stage exchange, although the difference did not achieve statistical significance (27% vs. 43%, P = .244). Patients infected with coagulase-negative Staphylococci experienced a higher rate of recurrent infection than those infected with other species (44% vs. 14%), although again this difference did not reach statistical significance (P = .060). In patients undergoing 2-stage exchange, incomplete cement removal was associated with a significantly higher rate of recurrent infection than complete removal (56% vs. 19%, P = .001), but intentional retention of 1 component was not significantly associated with a higher rate of recurrent infection (37% vs. 20%, P = .315).

Discussion

The results of this systematic review and meta-analysis of the outcomes associated with the treatment of TEA periprosthetic joint infection with either DAIR or 2-stage reimplantation, 2-stage exchange was associated with a lower rate of recurrent infection. Incomplete cement removal was a risk factor for recurrent infection. Although it did not reach significance, it appeared that infection with coagulase-negative Staphylococci could also be a risk factor for failure of infection eradication.
背景:全肘关节置换术(TEA)后假体周围关节感染与大量发病率和翻修手术的需要相关。本系统综述和荟萃分析的目的是总结关于2期换药和体外移植术、抗生素和植入物保留(DAIR)的研究,以确定复发感染率、复发感染的危险因素、非感染性并发症和功能结局的差异。方法于2024年3月对MEDLINE、EMBASE、Cochrane、Scopus和Web of Science数据库进行系统检索,确定两期翻修手术或DAIR治疗感染tea的研究。排除标准包括重复出版物、综述文章和平均随访时间少于1年的研究。最终的分析包括14项研究。提取的数据包括人口统计学、治疗方式、细菌种类、复发感染率和功能结果(活动范围数据和梅奥肘部表现评分)。结果14项研究共纳入290例感染tea,其中131例采用DAIR治疗,159例采用2期交换治疗。复发感染的总随机效应发生率为34%(95%可信区间:21%-47%)。与DAIR相比,2期换药后复发感染率显著降低(18% vs. 51%, P = 0.004)。非感染性并发症的总合并率为34%(95%可信区间:22%-46%)。根据现有数据,两期置换与DAIR的非感染性并发症发生率较低,但差异无统计学意义(27% vs 43%, P = 0.244)。凝固酶阴性葡萄球菌感染的患者复发率高于其他种类葡萄球菌感染的患者(44%比14%),尽管这种差异也没有达到统计学意义(P = 0.060)。在接受2期骨置换的患者中,不完全骨水泥移除与复发感染的比例明显高于完全移除(56% vs. 19%, P = .001),但故意保留一个骨水泥组件与复发感染的比例没有显著相关性(37% vs. 20%, P = .315)。本系统综述和荟萃分析的结果与DAIR或2期再植入术治疗TEA假体周围关节感染相关的结果,2期置换与较低的复发感染率相关。骨水泥去除不完全是复发性感染的危险因素。虽然没有达到显著性,但凝固酶阴性葡萄球菌感染也可能是感染根除失败的危险因素。
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引用次数: 0
Arthroscopic anterior glenoid reconstruction using distal tibial allograft with suture button fixation: 2-year postoperative clinical outcomes 关节镜下胫骨远端同种异体骨带缝合扣固定重建前盂关节:术后2年临床结果
Q4 Medicine Pub Date : 2025-10-28 DOI: 10.1016/j.xrrt.2025.100602
Grant Greaves BEng, MD, Ailar Ramadi PhD, Lauren Beaupre PhD, Dylan Alexander BSc, MSc (PT candidate), Martin Bouliane MD

Background

Anterior glenohumeral instability is a common cause of shoulder instability. Bony reconstruction with distal tibial allograft (DTA) is a relatively new technique with promising results. Screw fixation of the graft comes with certain risks including hardware complications requiring revision surgery, so a novel technique, arthroscopic DTA with double suture-button fixation, has been proposed. The purpose of our study was therefore to report the outcomes of arthroscopic DTA anterior glenoid reconstruction with double suture-button fixation.

Methods

A single-surgeon, single-center, mixed retrospective/prospective cohort review of patients who underwent arthroscopic DTA glenoid reconstruction with double-button suture anchor fixation between 2018 and 2022 in Alberta, Canada, was performed. The study included adult patients at least 18 years old at time of study with at least 13% glenoid bone loss and 2 years of follow-up. Chart reviews and telephone interviews were completed to assess for radiographic and clinical outcomes. Primary outcomes were failure rate, complication rate including infection, neurovascular injury, revision rate, reoperation rate, and patient-reported outcome measures.

Results

Forty-eight patients with mean age 31 ± 10 years (range 18-63) and 43 (90%) males were included. Mean follow-up was 63 ± 15 months (range 24-78 months). Seventeen patients (35%) had previous stabilization surgery. Mean preoperative glenoid bone loss was 32 ± 8%. Objective recurrent instability was observed in 10 (21%) patients. One (2%) patient required reoperation for loose suture material. Other complications include 1 (2%) pulmonary embolism and 1 (2%) neurovascular injury, both of which occurred in the same patient. The study was not powered to identify risk factors for failure, and odds ratios (ORs) did not achieve statistical significance for patients with a history of epilepsy (OR 4.4, P = .15), smoking (OR 6.8, P = .08), and substance use (OR 1.8, P = .81). Twenty-three participants (53%) completed a telephone interview with the following results: subjective persistent instability 9 (39%), chronic stiffness 9 (39%), mechanical symptoms 16 (70%), overall Single Assessment Numeric Evaluation score 87 ± 9, average Visual Analog Score 1.1 ± 1.5, and 20 (87%) were 'satisfied' or 'very satisfied' with their surgery.

Conclusion

The rate of recurrent instability is 21% in this challenging population. Reoperation rate for symptomatic hardware was 2%, and the other complication rate was 2%. While DTA reconstruction with suture button fixation can be considered an option in patients with risk factors for failure, patients should be counseled on the risk of recurrent instability and need for reoperation.
背景:前肩关节不稳定是导致肩关节不稳定的常见原因。胫骨远端同种异体骨重建(DTA)是一项相对较新的技术,具有良好的效果。螺钉固定移植物有一定的风险,包括需要翻修手术的硬件并发症,因此提出了一种新的技术,关节镜下DTA双缝线-扣固定。因此,我们研究的目的是报告关节镜下双缝扣固定DTA前盂重建的结果。方法对2018年至2022年在加拿大艾伯塔省接受关节镜DTA关节盂重建术双扣线锚定固定的患者进行单外科、单中心、混合回顾性/前瞻性队列研究。该研究包括18岁以上的成年患者,研究时至少有13%的盂骨丢失,随访2年。完成了图表回顾和电话访谈,以评估放射学和临床结果。主要结果包括失败率、并发症发生率(包括感染)、神经血管损伤、翻修率、再手术率和患者报告的结果测量。结果48例患者平均年龄(31±10岁)(18 ~ 63岁),男性43例(90%)。平均随访63±15个月(24 ~ 78个月)。17例患者(35%)既往有过稳定手术。术前平均盂骨丢失32±8%。目的10例(21%)患者出现复发性不稳定。1例(2%)患者因缝线材料松动需要再次手术。其他并发症包括1例(2%)肺栓塞和1例(2%)神经血管损伤,均发生在同一患者身上。该研究没有确定失败的危险因素,并且癫痫史(OR 4.4, P = 0.15)、吸烟史(OR 6.8, P = 0.08)和药物使用史(OR 1.8, P = 0.81)患者的比值比(OR)没有达到统计学意义。23名参与者(53%)完成了电话访谈,结果如下:主观持续不稳定9(39%),慢性僵硬9(39%),机械症状16(70%),整体单一评估数值评估评分87±9,平均视觉模拟评分1.1±1.5,20名(87%)对手术“满意”或“非常满意”。结论在这一具有挑战性的人群中,不稳定复发率为21%。症状性硬体再手术率为2%,其他并发症发生率为2%。虽然对于有失败风险因素的患者,可以考虑采用缝合扣固定的DTA重建,但应告知患者复发不稳定的风险和再次手术的必要性。
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引用次数: 0
Current outcomes of triceps-sparing elbow arthroplasties: a systematic review 保留肱三头肌肘关节置换术的当前疗效:系统回顾
Q4 Medicine Pub Date : 2025-10-28 DOI: 10.1016/j.xrrt.2025.100604
James R. Satalich MD , Shahabeddin Yazdanpanah MS , Grayson M. Talaski BSE , Devi-Preetham Veeramgari BS , Nicholas R. Kiritsis BS , John W. Cyrus MS , Benjamin P. Cassidy MD , Matthew S. Smith MD , Jennifer L. Vanderbeck MD

Background

Total elbow arthroplasty (TEA) is a reconstructive option for fractures, arthritis, and tumors, particularly in older adults. Approaches for the procedure can be categorized into triceps-sparing (TS) or triceps-detaching (TD). TD approaches are well-studied, but are associated with many complications such as infections, limited range of motion, and triceps insufficiency. Despite being more technically demanding, TS approaches are rising in popularity due to preservation of the triceps insertion. This study consolidates the most recent literature on TS-TEAs and TS elbow hemiarthroplasties (EHAs) to better inform updated clinical decision-making.

Methods

A PROSPERO-registered systematic review was conducted on March 10, 2025, searching PubMed, Ovid-Embase, MEDLINE, and Web of Science for studies published since 2020 that investigate TS elbow arthroplasty findings in adults. Extracted outcomes included demographics, range of motion metrics, and complications. Frequency-weighted means, t-tests, and chi-square tests were accordingly utilized in R Studio for statistical analyses.

Results

Eight moderate-quality retrospective studies were identified (5 TS-TEA and 3 TS-EHA) out of 290. Patients (n = 252; TS-TEA 195; TS-EHA 57) had average ages of 64.5 ± 12.5 and 73.1 ± 10.6, with average follow-ups of 43.8 ± 39.5 and 56.3 ± 20.0 months for TS-TEA and TS-EHA, respectively. Average flexion degrees were 129.7° ± 19.5 and 129.0° ± 13.8, followed by extension deficits at 17.9° ± 17.3 and 19.8° ± 12.9, respectively. Average postoperative prosupination arc ranges were 140.6°-144.6° and 155°-171°, respectively. Complication rates were 22.9% after TS-TEA and 54.4% after TS-EHA, characterized by literature-compared high rates of ulnar nerve symptoms and heterotopic ossification, but low rates of infection and triceps insufficiency.

Conclusion

TS approaches, either in TEA or EHA, are reasonable options for surgeons today. Further studies are recommended for more granular and consistent elucidation, with arthroplasty approaches remaining individualized to patient needs and surgeon preferences.
背景:全肘关节置换术(TEA)是骨折、关节炎和肿瘤的重建选择,特别是在老年人中。手术方法可分为保留肱三头肌(TS)或分离肱三头肌(TD)。TD入路已被充分研究,但与许多并发症相关,如感染、活动范围受限和三头肌功能不全。尽管技术要求更高,但由于保留了三头肌的插入,TS入路越来越受欢迎。本研究整合了TS- tea和TS肘关节半置换术(EHAs)的最新文献,以更好地为最新的临床决策提供信息。方法于2025年3月10日进行了一项普洛斯罗注册的系统评价,检索PubMed、Ovid-Embase、MEDLINE和Web of Science,检索自2020年以来发表的关于成人TS肘关节置换术结果的研究。提取的结果包括人口统计学、运动指标范围和并发症。因此,在R Studio中使用频率加权均值、t检验和卡方检验进行统计分析。结果从290篇回顾性研究中筛选出8篇中等质量的研究(5篇TS-TEA, 3篇TS-EHA)。患者252例,TS-TEA 195例,TS-EHA 57例,平均年龄64.5±12.5岁,73.1±10.6岁,TS-TEA和TS-EHA的平均随访时间分别为43.8±39.5个月和56.3±20.0个月。平均屈曲度为129.7°±19.5°和129.0°±13.8°,其次是伸展缺陷,分别为17.9°±17.3°和19.8°±12.9°。术后平均旋前弧度范围分别为140.6°~ 144.6°和155°~ 171°。TS-TEA术后的并发症发生率为22.9%,TS-EHA术后的并发症发生率为54.4%,与文献相比,尺神经症状和异位骨化发生率高,但感染和三头肌功能不全发生率低。结论TEA或EHA入路是当今外科医生的合理选择。建议进一步的研究进行更细致和一致的阐明,关节置换术的方法仍然根据患者的需要和外科医生的喜好进行个体化。
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引用次数: 0
Rotator cuff repair and biologic augmentation—what do we know? 肩袖修复和生物隆胸——我们知道些什么?
Q4 Medicine Pub Date : 2025-10-25 DOI: 10.1016/j.xrrt.2025.100605
Adam J. Tagliero MD , Erick M. Marigi MD , Christopher M. Hart MD , Tristan B. Weir MD , Gavin H. Ward BA , Christopher L. Camp MD , Jonathan D. Barlow MD , John W. Sperling MD, MBA , Joaquin Sanchez-Sotelo MD, PhD

Background

Despite advancements in rotator cuff repair (RCR) techniques, failure of tendon healing remains common. In recent years, there has been an increasing body of work assessing the healing environment of the injured rotator cuff and exploring which adjuncts may be suitable to augment repairs.

Methods

In this review, we summarize the best available literature regarding the biology of rotator cuff healing and the use of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), scaffold-, and graft-based augmentations to RCR to guide the treating clinician.

Results

Proposed treatment modalities range from injection-based augmentation such as PRP and BMAC to scaffold and graft-based augmentations at the time of RCR.

Conclusion

The field of biologic augmentation for RCR is rapidly evolving and has demonstrated substantial potential in improving structural integrity and healing rates. PRP, BMAC, as well as scaffold- or graft-based strategies, have all shown promise; however, variability in study methodology, preparation techniques, and clinical outcomes continue to limit definitive recommendations. Key challenges remain, including the need for optimization and standardization of biologic formulations, patient selection criteria, and cost-effective analyses. The need for well-powered, high-quality randomized controlled trials with standardized protocols are paramount to guiding clinical decision-making. The need to optimize RCR is clear, and the interest is evident in the numerous studies in the field. Future studies should aim to establish clear guidelines for biologic augmentation, ensuring that evidence-based applications can optimize patient outcomes in the future.
背景:尽管肩袖修复(RCR)技术取得了进步,但肌腱愈合失败仍然很常见。近年来,有越来越多的工作评估受伤的肩袖愈合环境,并探索哪些辅助物可能适合增加修复。方法在本综述中,我们总结了关于肩袖愈合的生物学和使用富血小板血浆(PRP)、骨髓浓缩物(BMAC)、支架和移植物为基础的RCR增强来指导临床医生的治疗。建议的治疗方式包括注射增强如PRP和BMAC,支架和移植物增强在RCR时。结论RCR生物增强技术正在快速发展,在改善结构完整性和愈合率方面具有巨大的潜力。PRP、BMAC以及基于支架或移植物的策略都显示出了希望;然而,研究方法、制备技术和临床结果的可变性仍然限制了明确的推荐。主要的挑战仍然存在,包括生物制剂的优化和标准化、患者选择标准和成本效益分析的需要。对标准化方案的高质量随机对照试验的需求对指导临床决策至关重要。优化RCR的必要性是明确的,并且在该领域的许多研究中都有明显的兴趣。未来的研究应旨在建立明确的生物增强指南,确保以证据为基础的应用可以在未来优化患者的预后。
{"title":"Rotator cuff repair and biologic augmentation—what do we know?","authors":"Adam J. Tagliero MD ,&nbsp;Erick M. Marigi MD ,&nbsp;Christopher M. Hart MD ,&nbsp;Tristan B. Weir MD ,&nbsp;Gavin H. Ward BA ,&nbsp;Christopher L. Camp MD ,&nbsp;Jonathan D. Barlow MD ,&nbsp;John W. Sperling MD, MBA ,&nbsp;Joaquin Sanchez-Sotelo MD, PhD","doi":"10.1016/j.xrrt.2025.100605","DOIUrl":"10.1016/j.xrrt.2025.100605","url":null,"abstract":"<div><h3>Background</h3><div>Despite advancements in rotator cuff repair (RCR) techniques, failure of tendon healing remains common. In recent years, there has been an increasing body of work assessing the healing environment of the injured rotator cuff and exploring which adjuncts may be suitable to augment repairs.</div></div><div><h3>Methods</h3><div>In this review, we summarize the best available literature regarding the biology of rotator cuff healing and the use of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), scaffold-, and graft-based augmentations to RCR to guide the treating clinician.</div></div><div><h3>Results</h3><div>Proposed treatment modalities range from injection-based augmentation such as PRP and BMAC to scaffold and graft-based augmentations at the time of RCR.</div></div><div><h3>Conclusion</h3><div>The field of biologic augmentation for RCR is rapidly evolving and has demonstrated substantial potential in improving structural integrity and healing rates. PRP, BMAC, as well as scaffold- or graft-based strategies, have all shown promise; however, variability in study methodology, preparation techniques, and clinical outcomes continue to limit definitive recommendations. Key challenges remain, including the need for optimization and standardization of biologic formulations, patient selection criteria, and cost-effective analyses. The need for well-powered, high-quality randomized controlled trials with standardized protocols are paramount to guiding clinical decision-making. The need to optimize RCR is clear, and the interest is evident in the numerous studies in the field. Future studies should aim to establish clear guidelines for biologic augmentation, ensuring that evidence-based applications can optimize patient outcomes in the future.</div></div>","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 1","pages":"Article 100605"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hospital, regional, and policy-level variations in shoulder arthroplasty prices: a Nationwide database study 医院、地区和政策层面的肩关节置换术价格变化:一项全国数据库研究
Q4 Medicine Pub Date : 2025-10-24 DOI: 10.1016/j.xrrt.2025.100601
Devika A. Shenoy BS, Katelyn E. Parsons BS, Kevin A. Wu MD, Aaron D. Therien MS, Yiqiu Zhang BS, Amanda Hayes MD, Christian A. Pean MD, MS, Christopher S. Klifto MD, William C. Eward MD, DVM

Background

Surgical reconstruction via hemiarthroplasty, anatomic total shoulder arthroplasty (aTSA), or reverse total shoulder arthroplasty (rTSA) is a common approach for treatment of various shoulder pathologies. Little is known about variations in negotiated payor rates for these procedures. The objective of this study was to examine hospital, regional, and policy-level factors associated with variations in negotiated rates for total shoulder arthroplasty (TSA) and hemiarthroplasty across the United States.

Methods

A cross-sectional analysis was performed with 2024 payor rate data from the Turquoise Health Database, using current procedural terminology codes for hemiarthroplasty (23470) and rTSA/aTSA (23472). Variables of interest were downloaded from publicly available sources, including hospital size, payor class, metropolitan/nonmetropolitan classification, regional household income, and Area Deprivation Index. State-level policies included Medicaid expansion status, certificate-of-need (CON) status, nurse practitioner scope-of-practice regulations, and participation in the All-Payer Claims Database (APCD). Multivariable linear regressions were used to assess associations between payor rates and variables of interest.

Results

In total, 516,904 total rates were evaluated (256,422 hemiarthroplasty; 260,480 rTSA/aTSA). The unadjusted mean negotiated rate was $9,082 (standard deviation: $1,182) for hemiarthroplasty and $10,840 (standard deviation: $1,405) for TSA. In a separate multivariable analysis, the mean rate difference was $68 (95% CI: $35-$102). Hospital bed capacity was tied to variations in both cohorts. Metropolitan hospitals reported higher payor rates for both hemiarthroplasty (+$2,151.46) and rTSA/aTSA (+$879.73) in comparison to nonmetropolitan hospitals. Medicaid expansion was associated with higher rates for both cohorts, while increased nurse practitioner scope of practice, CON status, and APCD database participation were associated with lower rates (P < .001).

Conclusion

Shoulder arthroplasty negotiated payor rates show large variations and are associated with several factors, including hospital size, payor class, and regional factors. Mean TSA rates were $68 higher, a clinically insignificant amount. States with CON laws and APCD database participation have lower payor rates while states with Medicaid expansion have higher rates. These findings underscore significant variations in how hospitals and payors negotiate rates for shoulder arthroplasty, emphasizing the many factors that play a role in shaping surgical costs.
背景:通过半关节置换术、解剖全肩关节置换术(aTSA)或反向全肩关节置换术(rTSA)进行手术重建是治疗各种肩关节病变的常用方法。关于这些程序的协商付款率的变化所知甚少。本研究的目的是检查医院、地区和政策层面的因素与全肩关节置换术(TSA)和半肩关节置换术谈判价格的变化有关。方法对来自Turquoise Health数据库的2024年支付率数据进行横断面分析,使用当前半关节置换术的程序术语代码(23470)和rTSA/aTSA(23472)。从公开来源下载感兴趣的变量,包括医院规模、付款人类别、大都市/非大都市分类、区域家庭收入和地区剥夺指数。州一级的政策包括医疗补助扩张状态,需求证明(CON)状态,执业护士的执业范围法规,以及参与所有付款人索赔数据库(APCD)。使用多变量线性回归来评估付款率与利率变量之间的关联。结果共评估516,904例(半关节置换术256,422例;rTSA/aTSA 260,480例)。未经调整的平均协商费用为半关节置换术9,082美元(标准差:1,182美元),TSA为10,840美元(标准差:1,405美元)。在单独的多变量分析中,平均比率差异为68美元(95% CI: 35- 102美元)。医院病床容量与两组人群的差异有关。与非大都市医院相比,大都市医院报告的半关节置换术(+ 2151.46美元)和rTSA/aTSA(+ 879.73美元)的支付率更高。在两个队列中,医疗补助扩张与较高的发生率相关,而执业护士的执业范围、CON状态和APCD数据库参与的增加与较低的发生率相关(P < 0.001)。结论肩关节置换术协商付款率差异较大,与医院规模、付款人类别和地区因素有关。平均TSA率高出68美元,临床意义不显著。拥有CON法律和参与APCD数据库的州的支付率较低,而扩大医疗补助计划的州的支付率较高。这些发现强调了医院和付款人协商肩关节置换术费用的显著差异,强调了影响手术费用的许多因素。
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引用次数: 0
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