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Preoperative humeral computed tomography may be a useful indicator of low bone mineral density in patients undergoing rotator cuff repair 术前肱骨计算机断层扫描可能是一个有用的指标低骨密度的患者进行肩袖修复
Q4 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.xrrt.2025.100624
Yuki Matsui MD, PhD , Yusuke Menjo MD , Yoshihiro Hojo MD, PhD , Daisuke Momma MD, PhD , Norimasa Iwasaki MD, PhD

Background

Bone fragility can compromise rotator cuff repair, particularly in patients with osteoporosis. Although previous studies have demonstrated correlations between systemic bone mineral density (BMD) and bone quality, only a few have focused on the anchor-relevant regions in patients with rotator cuff tears. We hypothesized that preoperative computed tomography (CT)-based Hounsfield unit (HU) values at anchor-relevant areas in the proximal humerus could be used to estimate systemic BMD in these patients.

Methods

This retrospective study included 58 patients (62 shoulders) who underwent arthroscopic rotator cuff repair and had both preoperative shoulder CT and dual energy X-ray absorptiometry scans. HU values were measured in 4 regions of interest within the proximal humerus: medial, central, lateral, and greater tuberosity (GT). Systemic BMD was assessed using femoral neck and lumbar spine T-scores and BMD values. Pearson correlation coefficients were used to evaluate the association between the HU values and systemic T-score/BMD. Multivariate linear regression analyses were performed using HU values at the GT after adjusting for age, sex, and rotator cuff tear size.

Results

HU values were significantly lower in the lateral and GT regions than in the medial and central regions (P < .01). Among regions, the HU values at the GT showed the highest correlations with the systemic T-scores and BMD (all moderate): femoral neck T-score (r = 0.57), lumbar spine T-score (r = 0.55), femoral neck BMD (r = 0.60), and lumbar spine BMD (r = 0.56) (all P < .01). Multivariate regression confirmed that GT values were independently associated with both femoral and lumbar T-score/BMD (adjusted R2 = 0.37-0.45, P < .001), even after controlling age, sex, and tear size.

Conclusion

Preoperative CT-derived HU values, particularly at the GT, have a moderate correlation with systemic T-scores and BMD in patients with rotator cuff tears. Given the lower HU values observed at the anchor insertion sites (GT and lateral regions), clinicians should consider the risk of bone fragility during surgical planning.
背景:骨脆性会影响肩袖修复,尤其是骨质疏松患者。虽然以前的研究已经证明了全身骨密度(BMD)和骨质量之间的相关性,但只有少数研究关注肩袖撕裂患者的锚定相关区域。我们假设术前基于肱骨近端锚定相关区域Hounsfield单位(HU)值的计算机断层扫描(CT)可用于评估这些患者的全身骨密度。方法回顾性研究纳入58例(62肩)行关节镜下肩袖修复术的患者,术前均行肩部CT和双能x线吸收仪扫描。测量肱骨近端内4个感兴趣区域的HU值:内侧、中央、外侧和大结节(GT)。采用股骨颈、腰椎t评分和骨密度值评估全身骨密度。使用Pearson相关系数评估HU值与系统t评分/BMD之间的关系。在调整年龄、性别和肩袖撕裂大小后,使用GT时的HU值进行多元线性回归分析。结果外侧和GT区的shu值明显低于内侧和中央区(P < 0.01)。在各区域中,GT时的HU值与全身t评分和骨密度相关性最高(均为中度):股骨颈t评分(r = 0.57)、腰椎t评分(r = 0.55)、股骨颈骨密度(r = 0.60)、腰椎骨密度(r = 0.56)(均P <; 0.01)。多因素回归证实GT值与股骨和腰椎t评分/BMD独立相关(校正R2 = 0.37-0.45, P < 0.001),即使在控制年龄、性别和撕裂大小后也是如此。结论:肩袖撕裂患者术前ct提取的HU值,特别是GT值,与全身t评分和骨密度有中等相关性。鉴于锚钉插入部位(GT和外侧区域)观察到较低的HU值,临床医生在计划手术时应考虑骨脆性的风险。
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引用次数: 0
Use of locking humeral stems in reverse total shoulder arthroplasty for complex proximal humerus fractures: a scoping review 在复杂肱骨近端骨折的反向全肩关节置换术中使用锁定肱骨柄:范围回顾
Q4 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.xrrt.2025.100625
Victor Cardona-Perez BS , Elyette Lugo BS , Alberto R. Rivera MD , Umasuthan Srikumaran MD, MBA, MPH
The use of locked humeral stems in reverse total shoulder arthroplasty (rTSA) has emerged as an alternative fixation strategy for treating complex proximal humerus fractures (PHFs). This scoping review synthesizes the available literature evaluating clinical outcomes, radiographic findings, and complications associated with interlocking humeral stems in rTSA for PHFs. Nine studies, encompassing 434 patients, were identified, of whom 308 underwent rTSA with a locking humeral stem. The mean patient age was 75.7 ± 5.1 years, with a mean follow-up of 20.0 ± 8.9 months, and at least 54% of patients were female. Postoperative functional outcomes demonstrated a mean forward flexion of 120° ± 13.2°, abduction of 101° ± 2.3°, external rotation of 29.3° ± 8.9°, and internal rotation to the lumbar spine. Patient-reported outcomes showed a mean Quick Disabilities of the Arm, Shoulder, and Hand score of 31.4 ± 4.2 and a Constant-Murley Score of 65.4 ± 10.7. Tuberosity healing was observed in 76% of cases. The overall complication rate was 13.0%, with locking screw -related complications occurring in 1.6% of cases, accounting for 12.5% of all reported complications. These findings suggest that locked humeral stems provide reliable diaphyseal fixation with a low incidence of screw-related complications in rTSA for complex PHFs. Long-term success depends on achieving stable metaphyseal fixation and osteointegration; cemented or press-fit stems without screws remain viable alternatives. Further prospective, comparative studies are needed to clarify long-term outcomes and optimize implant selection.
在反向全肩关节置换术(rTSA)中使用锁定肱骨柄已成为治疗复杂肱骨近端骨折(phf)的一种替代固定策略。本综述综合了现有的文献,评估了临床结果、影像学表现和与肱骨干互锁相关的rTSA治疗phf的并发症。9项研究共纳入434名患者,其中308人接受了肱骨干锁定的rTSA。患者平均年龄75.7±5.1岁,平均随访20.0±8.9个月,至少54%的患者为女性。术后功能结果显示,患者平均前屈120°±13.2°,外展101°±2.3°,外旋29.3°±8.9°,腰椎内旋。患者报告的结果显示手臂、肩部和手部的平均快速残疾评分为31.4±4.2,Constant-Murley评分为65.4±10.7。结节愈合率为76%。总并发症发生率为13.0%,其中锁定螺钉相关并发症发生率为1.6%,占所有报告并发症的12.5%。这些结果表明,在rTSA治疗复杂phf时,锁定肱骨柄提供可靠的骨干固定,螺钉相关并发症发生率低。长期成功依赖于稳定的干骺端固定和骨整合;没有螺钉的胶结或压合阀杆仍然是可行的选择。需要进一步的前瞻性比较研究来明确长期结果并优化种植体选择。
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引用次数: 0
Postoperative nonsteroidal anti-inflammatory drug prophylaxis for elbow heterotopic ossification: a systematic review and meta-analysis comparing COX-2 selective and nonselective inhibitors 肘关节异位骨化术后非甾体抗炎药预防:比较COX-2选择性和非选择性抑制剂的系统回顾和荟萃分析
Q4 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.xrrt.2025.100628
Areeb Ahmad BS , Roya Khorram MD , Kassem Ghayyad MD , Vraj Amin BS , Amir R. Kachooei MD, PhD , G. Russell Huffman MD, MPH , Daryl C. Osbahr MD , Luke S. Oh MD, MS

Background

Heterotopic ossification (HO) is a significant complication following elbow trauma and surgery, leading to pain, stiffness, and functional impairment. While nonsteroidal anti-inflammatory drugs (NSAIDs) have been extensively investigated for HO prophylaxis, their effectiveness in preventing postoperative HO in the elbow remains unclear. This study aims to compare the efficacy of selective vs. nonselective NSAIDs in reducing postoperative HO rates after traumatic elbow surgeries.

Methods

This systematic review and meta-analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search was performed in PubMed, Embase, Cochrane Library, and Web of Science from January 2004 to January 10, 2025. Level I-III studies were included if they examined patients who underwent elbow surgery following trauma and compared selective COX-2 inhibitors or nonselective NSAIDs to no prophylaxis, with reported postoperative HO formation rates.

Results

A total of 2,429 articles were identified across the four databases. Following full-text review, 1 randomized control trial and 5 retrospective studies were included in the quantitative synthesis, comprising patients who underwent either acute post-traumatic surgery or postexcision/open arthrolysis for established HO. Both selective (celecoxib) and nonselective (indomethacin) NSAIDs demonstrated no statistically significant difference in reducing postoperative HO compared with controls (celecoxib: risk ratio = 0.64, 95% confidence interval 0.32-1.31, P = .22; indomethacin: risk ratio = 0.87, 95% confidence interval 0.65-1.18, P = .38). Nonselective (indomethacin and ibuprofen) and selective (celecoxib) NSAID prophylaxis significantly reduced HO incidence compared to controls (P = .007), demonstrating a 27% relative risk reduction.

Conclusion

This study demonstrates that both selective (celecoxib) and nonselective (indomethacin and ibuprofen) NSAIDs effectively reduce the risk of HO following elbow trauma surgery. When analyzed individually, neither the selective COX-2 inhibitor (celecoxib) nor the nonselective NSAIDs (indomethacin, ibuprofen) showed a statistically significant difference compared with controls, indicating no clear difference in efficacy between NSAID classes. However, given the limited number of studies and interstudy heterogeneity, the overall power of the current evidence is low, and further prospective research is needed to validate these findings.
背景:异位骨化(HO)是肘关节创伤和手术后的一个重要并发症,可导致疼痛、僵硬和功能损害。虽然非甾体抗炎药(NSAIDs)已被广泛研究用于预防肘关节术后HO,但其预防肘关节术后HO的有效性尚不清楚。本研究旨在比较选择性与非选择性非甾体抗炎药在降低外伤性肘关节手术后HO发生率方面的疗效。方法本系统评价和荟萃分析遵循系统评价和荟萃分析指南的首选报告项目进行。从2004年1月到2025年1月10日,在PubMed、Embase、Cochrane Library和Web of Science中进行了全面的检索。I-III级研究包括创伤后接受肘部手术的患者,并比较选择性COX-2抑制剂或非选择性非甾体抗炎药与无预防的患者,报告术后HO形成率。结果4个数据库共鉴定出2429篇文献。在全文综述后,定量综合纳入了1项随机对照试验和5项回顾性研究,包括接受急性创伤后手术或切除后/开放关节松解术治疗已建立HO的患者。选择性(塞来昔布)和非选择性(吲哚美辛)非甾体抗炎药在降低术后HO方面与对照组相比均无统计学差异(塞来昔布:风险比= 0.64,95%可信区间0.32-1.31,P = 0.22;吲哚美辛:风险比= 0.87,95%可信区间0.65-1.18,P = 0.38)。与对照组相比,非选择性(吲哚美辛和布洛芬)和选择性(塞来昔布)非甾体抗炎药预防显著降低了HO发病率(P = 0.007),显示相对风险降低了27%。结论选择性非甾体抗炎药(塞来昔布)和非选择性非甾体抗炎药(吲哚美辛和布洛芬)均可有效降低肘部外伤术后发生HO的风险。单独分析时,选择性COX-2抑制剂(塞来昔布)和非选择性非甾体抗炎药(吲哚美辛、布洛芬)与对照组相比均无统计学差异,表明两类非甾体抗炎药的疗效无明显差异。然而,由于研究数量有限和研究间的异质性,目前证据的总体效力较低,需要进一步的前瞻性研究来验证这些发现。
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引用次数: 0
Outcomes of endoscopic, thoracic segment long thoracic nerve decompression 结果内镜下,胸段长胸神经减压
Q4 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.xrrt.2025.100629
Ryan Lohre MD, Sarah Koljaka BA, Nicholas Wiley MS, Joseph Macksood MS, Olive Kozelian BA, Bassem Elhassan MD

Background

Axillary and inferior periscapular pain often presents with scapulothoracic abnormal motion and observable winging and can be debilitating for patients. Our hypothesis is that endoscopic long thoracic nerve (LTN) decompression in the thoracic segment is effective at improving axillary and inferior periscapular border pain.

Methods

A retrospective chart review was performed of all patients diagnosed with persistent axillary and inferior periscapular border pain receiving endoscopic LTN decompression at a single institution, performed by 2 surgeons between 2020 and 2024. Patient demographics and patient pre- and postoperative patient-reported outcome measures were collected.

Results

Thirty-one patients receiving endoscopic LTN decompression were identified and included for analysis. The average follow-up was 25.1 ± 10.9 months, with an average patient age of 45.2 ± 18.1 years. Fifteen (n = 15/31; 48.4%) had prior ipsilateral upper-extremity surgery. Nineteen (n = 19/31; 61.2%) patients received a concomitant pectoralis minor release, 11 (n = 11/31; 35.5%) arthroscopic brachial plexus neurolysis, 10 (n = 10/31; 32.2%) arthroscopic scapulothoracic decompression, and 2 biceps tenodesis (n = 2/31; 6.5%) at the time of their arthroscopic LTN decompression. Visual analog scores (VAS) (7.7 ± 2.1 vs. 2.7 ± 2.7; P < .001) and subjective shoulder value (38.0 ± 24.2% vs. 85.6 ± 8.2%; P = .02) significantly improved after surgery. Patient-Reported Outcomes Measurement Information System (PROMIS) Short Form 7a (P = .35), PROMIS global physical (P = .58), PROMIS mental health (P = .65), and quick disabilities of the arm, shoulder, and hand (P = .11) did not significantly change after surgery. Measured forward elevation (127 ± 41° vs. 157 ± 10°; P = .003), abduction (117 ± 29° vs. 136 ± 14°; P = .01), and external rotation (54 ± 19° vs. 58 ± 4°; P = .009) significantly improved after surgery, while internal rotation (L1 ± 3 levels vs. T11 ± 2 levels; P = .11) remained unchanged. There were 4 (n = 4/31; 12.9%) complications characterized as persistent pain after surgery. There was one revision endoscopic LTN release (n = 1/31; 3.2%). There was no predictive patient (age, sex, body mass index, American Society of Anesthesiologists score, smoking status, diabetes, prior ipsilateral surgery) or surgical (operating room time) factors predisposing to surgical complications using logistic regression.

Conclusion

Thoracic-based, endoscopic decompression of the LTN improves pain, patient-reported outcome measures, and range of motion with minimal complications. Further study is required to determine long-term pain relief and outcomes.
背景:腋下和下肩胛骨周围疼痛通常表现为肩胸异常运动和可观察到的翅膀,并可使患者虚弱。我们的假设是内窥镜胸椎长神经(LTN)减压在胸段是有效的改善腋窝和下肩胛周围边界疼痛。方法回顾性分析2020年至2024年间,由2位外科医生在同一医院行LTN减压术的所有诊断为持续性腋窝和下肩胛周缘疼痛的患者。收集患者人口统计数据以及患者术前和术后患者报告的结果。结果31例患者接受内镜下LTN减压并纳入分析。平均随访25.1±10.9个月,平均年龄45.2±18.1岁。15例(n = 15/31; 48.4%)既往有同侧上肢手术史。19例(n = 19/31, 61.2%)患者同时接受了胸小肌松解术,11例(n = 11/31, 35.5%)患者接受了关节镜下臂丛神经松解术,10例(n = 10/31, 32.2%)患者接受了关节镜下肩胸减压术,2例(n = 2/31, 6.5%)患者接受了二头肌肌腱固定术。视觉模拟评分(VAS)(7.7±2.1 vs. 2.7±2.7;P < 0.001)和主观肩值(38.0±24.2% vs. 85.6±8.2%;P = 0.02)术后显著改善。患者报告的预后测量信息系统(PROMIS)短表7a (P = 0.35)、PROMIS整体身体状况(P = 0.58)、PROMIS心理健康状况(P = 0.65)以及手臂、肩部和手部的快速残疾(P = 0.11)在手术后没有显著变化。手术后测量的前抬高(127±41°vs 157±10°,P = 0.003)、外展(117±29°vs 136±14°,P = 0.01)和外旋(54±19°vs 58±4°,P = 0.009)显著改善,而内旋(L1±3个水平vs T11±2个水平,P = 0.009)保持不变。有4例(n = 4/31; 12.9%)并发症表现为术后持续疼痛。内镜下LTN释放1例(n = 1/31; 3.2%)。采用logistic回归分析,没有预测患者(年龄、性别、体重指数、美国麻醉医师学会评分、吸烟状况、糖尿病、既往同侧手术)或手术(手术室时间)因素易导致手术并发症。结论:胸腔镜下LTN减压可改善疼痛、患者报告的预后指标和活动范围,并发症最少。需要进一步的研究来确定长期的疼痛缓解和结果。
{"title":"Outcomes of endoscopic, thoracic segment long thoracic nerve decompression","authors":"Ryan Lohre MD,&nbsp;Sarah Koljaka BA,&nbsp;Nicholas Wiley MS,&nbsp;Joseph Macksood MS,&nbsp;Olive Kozelian BA,&nbsp;Bassem Elhassan MD","doi":"10.1016/j.xrrt.2025.100629","DOIUrl":"10.1016/j.xrrt.2025.100629","url":null,"abstract":"<div><h3>Background</h3><div>Axillary and inferior periscapular pain often presents with scapulothoracic abnormal motion and observable winging and can be debilitating for patients. Our hypothesis is that endoscopic long thoracic nerve (LTN) decompression in the thoracic segment is effective at improving axillary and inferior periscapular border pain.</div></div><div><h3>Methods</h3><div>A retrospective chart review was performed of all patients diagnosed with persistent axillary and inferior periscapular border pain receiving endoscopic LTN decompression at a single institution, performed by 2 surgeons between 2020 and 2024. Patient demographics and patient pre- and postoperative patient-reported outcome measures were collected.</div></div><div><h3>Results</h3><div>Thirty-one patients receiving endoscopic LTN decompression were identified and included for analysis. The average follow-up was 25.1 ± 10.9 months, with an average patient age of 45.2 ± 18.1 years. Fifteen (n = 15/31; 48.4%) had prior ipsilateral upper-extremity surgery. Nineteen (n = 19/31; 61.2%) patients received a concomitant pectoralis minor release, 11 (n = 11/31; 35.5%) arthroscopic brachial plexus neurolysis, 10 (n = 10/31; 32.2%) arthroscopic scapulothoracic decompression, and 2 biceps tenodesis (n = 2/31; 6.5%) at the time of their arthroscopic LTN decompression. Visual analog scores (VAS) (7.7 ± 2.1 vs. 2.7 ± 2.7; <em>P</em> &lt; .001) and subjective shoulder value (38.0 ± 24.2% vs. 85.6 ± 8.2%; <em>P</em> = .02) significantly improved after surgery. Patient-Reported Outcomes Measurement Information System (PROMIS) Short Form 7a (<em>P</em> = .35), PROMIS global physical (<em>P</em> = .58), PROMIS mental health (<em>P</em> = .65), and quick disabilities of the arm, shoulder, and hand (<em>P</em> = .11) did not significantly change after surgery. Measured forward elevation (127 ± 41° vs. 157 ± 10°; <em>P</em> = .003), abduction (117 ± 29° vs. 136 ± 14°; <em>P</em> = .01), and external rotation (54 ± 19° vs. 58 ± 4°; <em>P</em> = .009) significantly improved after surgery, while internal rotation (L1 ± 3 levels vs. T11 ± 2 levels; <em>P</em> = .11) remained unchanged. There were 4 (n = 4/31; 12.9%) complications characterized as persistent pain after surgery. There was one revision endoscopic LTN release (n = 1/31; 3.2%). There was no predictive patient (age, sex, body mass index, American Society of Anesthesiologists score, smoking status, diabetes, prior ipsilateral surgery) or surgical (operating room time) factors predisposing to surgical complications using logistic regression.</div></div><div><h3>Conclusion</h3><div>Thoracic-based, endoscopic decompression of the LTN improves pain, patient-reported outcome measures, and range of motion with minimal complications. Further study is required to determine long-term pain relief and outcomes.</div></div>","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 2","pages":"Article 100629"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between testosterone replacement therapy and incidence of proximal humerus fractures in men: a matched retrospective analysis 睾酮替代治疗与男性肱骨近端骨折发生率之间的关系:一项匹配的回顾性分析
Q4 Medicine Pub Date : 2025-12-01 DOI: 10.1016/j.xrrt.2025.100631
Paul-Hugo Arcand BA , Simbarashe J. Peresuh MD , Joseph Confessore BS , Edward J. Testa MD , Matthew Quinn MD , Manjot Singh BS , Gabriella J. Avellino MD , Alan H. Daniels MD , Michel A. Arcand MD

Background

Anabolic androgenic steroid supraphysiologic dose use is linked to an increased risk of tendon rupture. Testosterone replacement therapy (TRT) is used to treat hypogonadism and is associated with increased bone mineral density. However, its relationship with fracture risk, particularly proximal humerus fractures (PHF), remains uncertain. This study evaluates the association between TRT and the incidence of PHFs using a large national database. We hypothesized that TRT use would be associated with a difference in the incidence of PHFs compared to a control group due to testosterone's role in maintaining bone mineral density.

Methods

This retrospective study with one-to-one matching queried the PearlDiver Mariner165 dataset to obtain a random sample of 500,000 patients aged 35 to 75 who received TRT continuously for at least 3 months and a random control sample of 500,000 different patients. Of the targeted 1,000,000 patients, 335,753 pairs of patients were matched based on age, tobacco use, diabetes history, and the Charlson Comorbidity Index. Incidence of PHF was assessed over a 2-year follow-up using the International Classification of Diseases codes, with comparisons made across the different cohorts. Multivariable logistic regression was conducted to identify the association between TRT use with PHF in men. An alpha level of 0.01 was prespecified to reduce the risk of type I error and ensure statistical rigor.

Results

In this matched-cohort study of 335,753 paired TRT and control patients, the mean age was 53.82 ± 10.58 years. Patients administered TRT demonstrated a higher incidence of PHF compared to the control cohort (0.029% vs. 0.005%, P < .001). Logistic regression analysis demonstrated that TRT was associated with a significantly increased risk of PHF (adjusted odds ratio 3.14; 95% confidence interval: 1.84-5.59; P < .001).

Conclusions

In this retrospective matched-cohort study, TRT patients demonstrated an increase in 2-year incidence rates of PHF in men. These findings underscore the need for tailored patient management and provide actionable insights for orthopedic practice. Future studies of prospective design are needed to better address confounding factors, establish causation, and evaluate surgical outcomes in TRT patients.
背景:代谢雄激素类固醇的超生理剂量使用与肌腱断裂风险增加有关。睾酮替代疗法(TRT)用于治疗性腺功能减退,并与骨矿物质密度增加有关。然而,其与骨折风险,特别是肱骨近端骨折(PHF)的关系仍不确定。本研究使用大型国家数据库评估TRT与phf发生率之间的关系。我们假设,由于睾酮在维持骨密度方面的作用,与对照组相比,TRT的使用可能与phf发病率的差异有关。方法采用一对一匹配的回顾性研究方法,查询PearlDiver Mariner165数据集,随机抽取50万例35 ~ 75岁连续接受TRT治疗至少3个月的患者,并随机抽取50万例不同患者作为对照。在目标的1,000,000例患者中,335,753对患者根据年龄、烟草使用、糖尿病史和Charlson合并症指数进行匹配。使用国际疾病分类代码对PHF的发病率进行了为期2年的随访评估,并对不同队列进行了比较。进行多变量逻辑回归以确定男性使用TRT与PHF之间的关系。预先设定alpha水平为0.01,以减少I型错误的风险并确保统计严谨性。结果该配对队列研究纳入了335,753例配对的TRT与对照患者,平均年龄为53.82±10.58岁。与对照组相比,接受TRT治疗的患者PHF发病率更高(0.029%对0.005%,P < 0.001)。Logistic回归分析显示,TRT与PHF风险显著增加相关(校正优势比3.14;95%可信区间:1.84-5.59;P < 0.001)。结论:在这项回顾性匹配队列研究中,TRT患者显示男性2年PHF发病率增加。这些发现强调了定制患者管理的必要性,并为骨科实践提供了可操作的见解。未来的前瞻性设计研究需要更好地解决混杂因素,建立因果关系,并评估TRT患者的手术结果。
{"title":"The relationship between testosterone replacement therapy and incidence of proximal humerus fractures in men: a matched retrospective analysis","authors":"Paul-Hugo Arcand BA ,&nbsp;Simbarashe J. Peresuh MD ,&nbsp;Joseph Confessore BS ,&nbsp;Edward J. Testa MD ,&nbsp;Matthew Quinn MD ,&nbsp;Manjot Singh BS ,&nbsp;Gabriella J. Avellino MD ,&nbsp;Alan H. Daniels MD ,&nbsp;Michel A. Arcand MD","doi":"10.1016/j.xrrt.2025.100631","DOIUrl":"10.1016/j.xrrt.2025.100631","url":null,"abstract":"<div><h3>Background</h3><div>Anabolic androgenic steroid supraphysiologic dose use is linked to an increased risk of tendon rupture. Testosterone replacement therapy (TRT) is used to treat hypogonadism and is associated with increased bone mineral density. However, its relationship with fracture risk, particularly proximal humerus fractures (PHF), remains uncertain. This study evaluates the association between TRT and the incidence of PHFs using a large national database. We hypothesized that TRT use would be associated with a difference in the incidence of PHFs compared to a control group due to testosterone's role in maintaining bone mineral density.</div></div><div><h3>Methods</h3><div>This retrospective study with one-to-one matching queried the PearlDiver Mariner165 dataset to obtain a random sample of 500,000 patients aged 35 to 75 who received TRT continuously for at least 3 months and a random control sample of 500,000 different patients. Of the targeted 1,000,000 patients, 335,753 pairs of patients were matched based on age, tobacco use, diabetes history, and the Charlson Comorbidity Index. Incidence of PHF was assessed over a 2-year follow-up using the International Classification of Diseases codes, with comparisons made across the different cohorts. Multivariable logistic regression was conducted to identify the association between TRT use with PHF in men. An alpha level of 0.01 was prespecified to reduce the risk of type I error and ensure statistical rigor.</div></div><div><h3>Results</h3><div>In this matched-cohort study of 335,753 paired TRT and control patients, the mean age was 53.82 ± 10.58 years. Patients administered TRT demonstrated a higher incidence of PHF compared to the control cohort (0.029% vs. 0.005%, <em>P</em> &lt; .001). Logistic regression analysis demonstrated that TRT was associated with a significantly increased risk of PHF (adjusted odds ratio 3.14; 95% confidence interval: 1.84-5.59; <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>In this retrospective matched-cohort study, TRT patients demonstrated an increase in 2-year incidence rates of PHF in men. These findings underscore the need for tailored patient management and provide actionable insights for orthopedic practice. Future studies of prospective design are needed to better address confounding factors, establish causation, and evaluate surgical outcomes in TRT patients.</div></div>","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 2","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of a proximal humerus nonunion with an extramedullary calcar replacing iliac crest autograft: surgical technique and review of the literature 肱骨近端骨不连髓外骨骨置换自体髂骨移植物的治疗:手术技术和文献回顾
Q4 Medicine Pub Date : 2025-11-29 DOI: 10.1016/j.xrrt.2025.100626
Bradley W. Fossum MD, Daniel Z. You MD, MSc, FRCSC, Samuel S. Rudisill MD, Joaquin Sanchez-Sotelo MD, PhD
{"title":"Management of a proximal humerus nonunion with an extramedullary calcar replacing iliac crest autograft: surgical technique and review of the literature","authors":"Bradley W. Fossum MD,&nbsp;Daniel Z. You MD, MSc, FRCSC,&nbsp;Samuel S. Rudisill MD,&nbsp;Joaquin Sanchez-Sotelo MD, PhD","doi":"10.1016/j.xrrt.2025.100626","DOIUrl":"10.1016/j.xrrt.2025.100626","url":null,"abstract":"","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 2","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allograft strut–screw construct in the management of total elbow periprosthetic fractures: a surgical technique with high complication rate 同种异体支架-螺钉结构治疗全肘关节假体周围骨折:一种高并发症的手术技术
Q4 Medicine Pub Date : 2025-11-29 DOI: 10.1016/j.xrrt.2025.100627
Julia C. Mastracci MD , Nainisha Chintalapudi MD , James Tyler Frix MD , R. Glenn Gaston MD , Bryan J. Loeffler MD
{"title":"Allograft strut–screw construct in the management of total elbow periprosthetic fractures: a surgical technique with high complication rate","authors":"Julia C. Mastracci MD ,&nbsp;Nainisha Chintalapudi MD ,&nbsp;James Tyler Frix MD ,&nbsp;R. Glenn Gaston MD ,&nbsp;Bryan J. Loeffler MD","doi":"10.1016/j.xrrt.2025.100627","DOIUrl":"10.1016/j.xrrt.2025.100627","url":null,"abstract":"","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 2","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of engaging reverse Hill-Sachs lesions with press-fit large fresh osteochondral allografts: a technical note 压合大新鲜骨软骨同种异体移植物治疗反向Hill-Sachs病变:技术说明
Q4 Medicine Pub Date : 2025-11-19 DOI: 10.1016/j.xrrt.2025.100620
Jamal Zahir BS, Kassem Ghayyad MD, Daniel Goltz MD, G. Russell Huffman MD, MPH, FAAOS
{"title":"Treatment of engaging reverse Hill-Sachs lesions with press-fit large fresh osteochondral allografts: a technical note","authors":"Jamal Zahir BS,&nbsp;Kassem Ghayyad MD,&nbsp;Daniel Goltz MD,&nbsp;G. Russell Huffman MD, MPH, FAAOS","doi":"10.1016/j.xrrt.2025.100620","DOIUrl":"10.1016/j.xrrt.2025.100620","url":null,"abstract":"","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 1","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-stage early reconstruction for neglected elbow dislocation with heterotopic ossification 被忽视的肘关节脱位伴异位骨化的一期早期重建
Q4 Medicine Pub Date : 2025-11-19 DOI: 10.1016/j.xrrt.2025.100619
Ryosuke Sato MD , Tomohiro Goto MD, PhD , Tetsuya Enishi MD, PhD , Michihiro Takai MD, PhD , Yasuyuki Omichi MD, PhD , Yusaku Nakayama MD , Gakuto Yoshida MD , Shunji Nakano MD, PhD , Koichi Sairyo MD, PhD
{"title":"One-stage early reconstruction for neglected elbow dislocation with heterotopic ossification","authors":"Ryosuke Sato MD ,&nbsp;Tomohiro Goto MD, PhD ,&nbsp;Tetsuya Enishi MD, PhD ,&nbsp;Michihiro Takai MD, PhD ,&nbsp;Yasuyuki Omichi MD, PhD ,&nbsp;Yusaku Nakayama MD ,&nbsp;Gakuto Yoshida MD ,&nbsp;Shunji Nakano MD, PhD ,&nbsp;Koichi Sairyo MD, PhD","doi":"10.1016/j.xrrt.2025.100619","DOIUrl":"10.1016/j.xrrt.2025.100619","url":null,"abstract":"","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 1","pages":"Article 100619"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term outcomes of hemiarthroplasty for complex proximal humerus fractures: a systematic review of clinical studies with minimum 10-year follow-up 复杂肱骨近端骨折半关节置换术的长期疗效:对至少10年随访的临床研究的系统回顾
Q4 Medicine Pub Date : 2025-11-19 DOI: 10.1016/j.xrrt.2025.100616
Logan D. Moews BS , Lord J. Hyeamang BA , Alexander L. Hornung MD , Tomas F. Vega MD , Jacob T. Morgan BA , Amelia Hummel MD , Matthew E. Henriques MD , Andrew S. Bi MD , Nikhil N. Verma MD

Background

While hemiarthroplasty (HA) has decreased in use as a surgical treatment for complex proximal humerus fractures, its long-term performance remains poorly defined. This systematic review evaluates clinical and functional outcomes and complication rates following HA with minimum 10-year follow-up.

Methods

A systematic search of PubMed, Embase, and Scopus was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify clinical studies reporting ≥10-year outcomes of HA for acute complex (3- or 4-part, fracture dislocations, or head split) proximal humerus fractures. Included studies reported functional or patient-reported outcomes and had a minimum average follow-up of 10 years. Study quality was assessed using the Methodological Index for Non-Randomized Studies criteria.

Results

Five studies encompassing 198 patients met the inclusion criteria. Mean follow-up ranged from 10.3 to 20.5 years. Postoperative Constant scores ranged from 63.9 to 82.8. Mean forward flexion ranged from 100.0° to 126.0°, and external rotation ranged from 28.0° to 46.0°. Greater tuberosity healing rates ranged from 30.0% to 91.0%, with improved clinical outcomes associated with anatomic healing at the greater tuberosity. Failure rates ranged from 0% to 29%, most commonly due to tuberosity malunion or nonunion. Glenoid erosion was reported in up to 72.7% of patients at a mean follow-up of 20.3 years. The overall complication (range, 0%-3.2%) and reoperation (range, 0%-12.9%) rates were low. Most failures were converted to reverse total shoulder arthroplasty.

Conclusion

HA for the treatment of complex proximal humerus fractures yields variable long-term clinical outcomes and high rates of failure, with the majority due to greater tuberosity malunion or nonunion. Anatomic greater tuberosity healing appears to result in improved function and lower failure risk. These findings suggest limited utility of HA in the long term, supporting the need for careful patient selection and consideration of alternative surgical options such as reverse shoulder arthroplasty for treatment of complex proximal humerus fractures.
虽然半关节置换术(HA)作为复杂肱骨近端骨折的手术治疗已经减少,但其长期疗效仍不明确。本系统综述通过至少10年随访评估HA的临床和功能结果以及并发症发生率。方法根据系统评价和荟萃分析指南的首选报告项目,对PubMed、Embase和Scopus进行系统检索,以确定报告HA治疗急性复杂(3部或4部骨折脱位或头裂)肱骨近端骨折≥10年结局的临床研究。纳入的研究报告了功能或患者报告的结果,平均随访时间至少为10年。采用非随机研究标准的方法学指数评估研究质量。结果5项研究共198例患者符合纳入标准。平均随访时间为10.3 - 20.5年。术后恒评分从63.9到82.8。平均前屈范围为100.0°至126.0°,外旋范围为28.0°至46.0°。大结节的愈合率从30.0%到91.0%不等,与大结节解剖愈合相关的临床结果得到改善。失败率从0%到29%不等,最常见的原因是结节畸形愈合或不愈合。在平均20.3年的随访中,高达72.7%的患者报告了关节盂糜烂。总并发症(范围0 ~ 3.2%)和再手术(范围0 ~ 12.9%)发生率较低。大多数失败转化为反向全肩关节置换术。结论ha治疗复杂肱骨近端骨折的长期临床结果多变,失败率高,主要原因是大结节不愈合或不愈合。解剖性大结节愈合可改善功能,降低手术失败风险。这些研究结果表明,从长期来看,HA的效用有限,因此需要仔细选择患者,并考虑其他手术选择,如治疗复杂肱骨近端骨折的反向肩关节置换术。
{"title":"Long-term outcomes of hemiarthroplasty for complex proximal humerus fractures: a systematic review of clinical studies with minimum 10-year follow-up","authors":"Logan D. Moews BS ,&nbsp;Lord J. Hyeamang BA ,&nbsp;Alexander L. Hornung MD ,&nbsp;Tomas F. Vega MD ,&nbsp;Jacob T. Morgan BA ,&nbsp;Amelia Hummel MD ,&nbsp;Matthew E. Henriques MD ,&nbsp;Andrew S. Bi MD ,&nbsp;Nikhil N. Verma MD","doi":"10.1016/j.xrrt.2025.100616","DOIUrl":"10.1016/j.xrrt.2025.100616","url":null,"abstract":"<div><h3>Background</h3><div>While hemiarthroplasty (HA) has decreased in use as a surgical treatment for complex proximal humerus fractures, its long-term performance remains poorly defined. This systematic review evaluates clinical and functional outcomes and complication rates following HA with minimum 10-year follow-up.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Embase, and Scopus was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify clinical studies reporting ≥10-year outcomes of HA for acute complex (3- or 4-part, fracture dislocations, or head split) proximal humerus fractures. Included studies reported functional or patient-reported outcomes and had a minimum average follow-up of 10 years. Study quality was assessed using the Methodological Index for Non-Randomized Studies criteria.</div></div><div><h3>Results</h3><div>Five studies encompassing 198 patients met the inclusion criteria. Mean follow-up ranged from 10.3 to 20.5 years. Postoperative Constant scores ranged from 63.9 to 82.8. Mean forward flexion ranged from 100.0° to 126.0°, and external rotation ranged from 28.0° to 46.0°. Greater tuberosity healing rates ranged from 30.0% to 91.0%, with improved clinical outcomes associated with anatomic healing at the greater tuberosity. Failure rates ranged from 0% to 29%, most commonly due to tuberosity malunion or nonunion. Glenoid erosion was reported in up to 72.7% of patients at a mean follow-up of 20.3 years. The overall complication (range, 0%-3.2%) and reoperation (range, 0%-12.9%) rates were low. Most failures were converted to reverse total shoulder arthroplasty.</div></div><div><h3>Conclusion</h3><div>HA for the treatment of complex proximal humerus fractures yields variable long-term clinical outcomes and high rates of failure, with the majority due to greater tuberosity malunion or nonunion. Anatomic greater tuberosity healing appears to result in improved function and lower failure risk. These findings suggest limited utility of HA in the long term, supporting the need for careful patient selection and consideration of alternative surgical options such as reverse shoulder arthroplasty for treatment of complex proximal humerus fractures.</div></div>","PeriodicalId":74030,"journal":{"name":"JSES reviews, reports, and techniques","volume":"6 1","pages":"Article 100616"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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JSES reviews, reports, and techniques
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