JVS-vascular science最新文献

{"title":"Microbe-derived Butyrate Activation of Free Fatty Acid Receptor-3 Reduces Neointimal Hyperplasia after Arterial Injury by Regulating Immune Response Transcription Networks in Endothelial Cells","authors":"Jonathan Jung , Sarbjeet Niraula , James Du , Vivek Pamulapati , Jae Woong Jang , Liqun Xiong , M. Luisa Iruela-Arispe , Michael R. MacArthur , Karen J. Ho","doi":"10.1016/j.jvssci.2023.100144","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100144","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000482/pdfft?md5=256c59b9ef44f830c8190db4bed5e3b4&pid=1-s2.0-S2666350323000482-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139107307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purinergic Receptor P2Y6 Mediates Perfusion Recovery After Femoral Artery Ligation","authors":"Rohan N. Kulkarni , Dylan McCreary , Nolan Skirtich , Michael Calderon , Ryan M. McEnaney","doi":"10.1016/j.jvssci.2023.100171","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100171","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000755/pdfft?md5=41526174ad4306405950047e9ea3a1bd&pid=1-s2.0-S2666350323000755-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and Is Associated With Blood Pressure","authors":"Kevin Mangum, Amrita Joshi, Sonya Wolf, Emily Barrett, Jadie Moon, Bethany Moore, Andrea T. Obi, Frank Davis, Katherine A. Gallagher","doi":"10.1016/j.jvssci.2023.100149","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100149","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000536/pdfft?md5=8256b9a4b886d0a68e2a5171059a36e6&pid=1-s2.0-S2666350323000536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Info for readers","authors":"","doi":"10.1016/S2666-3503(23)00090-1","DOIUrl":"https://doi.org/10.1016/S2666-3503(23)00090-1","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000901/pdfft?md5=284d5d8af825949e51552ff5f69a85ab&pid=1-s2.0-S2666350323000901-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Events of interest","authors":"","doi":"10.1016/S2666-3503(23)00091-3","DOIUrl":"https://doi.org/10.1016/S2666-3503(23)00091-3","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000913/pdfft?md5=fa66f2c2a16d0d277accbb1cda26aba9&pid=1-s2.0-S2666350323000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide Association Study of Intracranial Aneurysms Reveals Shared Heritability With Aortic Aneurysms and Atherosclerosis","authors":"Shaunak Adkar , Julie Lynch , Sharika Bamezai , Sabina Sorondo , Ryan Choi , Michael Levin , Scott M. Damrauer , Saiju Pyarajan , Philip S. Tsao , Stephen Skirboll , Nick J. Leeper , Derek Klarin","doi":"10.1016/j.jvssci.2023.100160","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100160","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000640/pdfft?md5=6a55a4435a65814778e2127e6157f893&pid=1-s2.0-S2666350323000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Basis of Thoracic Aortic Aneurysms in a Large Unselected Clinical Population","authors":"Hannah S. Mirshahi, Jeremy S. Haley, Diane T. Smelser, Evan J. Ryer, James R. Elmore, David J. Carey","doi":"10.1016/j.jvssci.2023.100164","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100164","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000688/pdfft?md5=8fb2a120f05fb4b5a9039cc07df12742&pid=1-s2.0-S2666350323000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a targeted approach to diabetes-related peripheral arterial occlusive disease","authors":"Rym El Khoury MD , Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2023.100112","DOIUrl":"10.1016/j.jvssci.2023.100112","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/79/main.PMC10366572.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-powered assessment of biomarkers for growth prediction of abdominal aortic aneurysms","authors":"Arianna Forneris PhD ,&nbsp;Richard Beddoes MSc ,&nbsp;Mitchel Benovoy PhD ,&nbsp;Peter Faris PhD ,&nbsp;Randy D. Moore MD ,&nbsp;Elena S. Di Martino PhD","doi":"10.1016/j.jvssci.2023.100119","DOIUrl":"10.1016/j.jvssci.2023.100119","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study was to employ biomechanics-based biomarkers to locally characterize abdominal aortic aneurysm (AAA) tissue and investigate their relation to local aortic growth by means of an artificial intelligence model.</p></div><div><h3>Methods</h3><p>The study focused on a population of 36 patients with AAAs undergoing serial monitoring with electrocardiogram-gated multiphase computed tomography angiography acquisitions. The geometries of the aortic lumen and wall were reconstructed from the baseline scans and used for the baseline assessment of regional aortic weakness with three functional biomarkers, time-averaged wall-shear stress, in vivo principal strain, and intra-luminal thrombus thickness. The biomarkers were encoded as regional averages on axial and circumferential sections perpendicularly to the aortic centerline. Local diametric growth was obtained as difference in diameter between baseline and follow-up at the level of each axial section. An artificial intelligence model was developed to predict accelerated aneurysmal growth with the Extra Trees algorithm used as a binary classifier where the positive class represented regions that grew more than 2.5 mm/year. Additional clinical biomarkers, such as maximum aortic diameter at baseline, were also investigated as predictors of growth.</p></div><div><h3>Results</h3><p>The area under the curve for the constructed receiver operating characteristic curve for the Extra Trees classifier showed a very good performance in predicting relevant aortic growth (area under the curve = 0.92), with the three biomechanics-based functional biomarkers being objectively selected as the main predictors of growth.</p></div><div><h3>Conclusions</h3><p>The use of features based on the functional and local characterization of the aortic tissue resulted in a superior performance in terms of growth prediction when compared with models based on geometrical assessments. With rapid growth linked to increasing risk for patients with AAAs, the ability to access functional information related to tissue weakening and disease progression at baseline has the potential to support early clinical decisions and improve disease management.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/45/main.PMC10470267.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization","authors":"Kevin Kiesworo MS ,&nbsp;Michael R. MacArthur PhD ,&nbsp;Peter Kip MD, PhD ,&nbsp;Thomas Agius MS ,&nbsp;Diane Macabrey MS ,&nbsp;Martine Lambelet BS ,&nbsp;Lauriane Hamard PhD ,&nbsp;C.-Keith Ozaki MD ,&nbsp;James R. Mitchell PhD ,&nbsp;Sébastien Déglise MD ,&nbsp;Sarah J. Mitchell PhD ,&nbsp;Florent Allagnat PhD ,&nbsp;Alban Longchamp MD, PhD","doi":"10.1016/j.jvssci.2022.11.003","DOIUrl":"10.1016/j.jvssci.2022.11.003","url":null,"abstract":"<div><h3>Objective</h3><p>Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease. However, the benefits of increasing endogenous CGL and its mechanism of action have not yet been elucidated.</p></div><div><h3>Methods</h3><p>Male whole body CGL-overexpressing transgenic (CGL^Tg) mice and wild-type (WT) littermates (C57BL/6J) were subjected to the hindlimb ischemia model (age, 10-12 weeks). Functional recovery was assessed via the treadmill exercise endurance test. Leg perfusion was measured by laser Doppler imaging and vascular endothelial-cadherin immunostaining. To examine the angiogenic potential, aortic ring sprouting assay and postnatal mouse retinal vasculature development studies were performed. Finally, comparative metabolomics analysis, oxidized/reduced nicotinamide adenine dinucleotide (NAD⁺/NADH) analysis, and quantitative real-time polymerase chain reaction were performed on CGL^WT and CGL^Tg gastrocnemius muscle.</p></div><div><h3>Results</h3><p>The restoration of blood flow occurred more rapidly in CGL^Tg mice. Compared with the CGL^WT mice, the median ± standard deviation running distance and time were increased for the CGL^Tg mice after femoral artery ligation (159 ± 53 m vs 291 ± 74 m [<em>P</em> &lt; .005] and 17 ± 4 minutes vs 27 ± 5 minutes [<em>P</em> &lt; .05], respectively). Consistently, in the CGL^Tg ischemic gastrocnemius muscle, the capillary density was increased fourfold (0.05 ± 0.02 vs 0.20 ± 0.12; <em>P</em> &lt; .005). Ex vivo, the endothelial cell (EC) sprouting length was increased in aorta isolated from CGL^Tg mice, especially when cultured in VEGFA (vascular endothelial growth factor A)-only media (63 ± 2 pixels vs 146 ± 52 pixels; <em>P</em> &lt; .05). Metabolomics analysis demonstrated a higher level of niacinamide, a precursor of NAD⁺/NADH in the muscle of CGL^Tg mice (61.4 × 10⁶ ± 5.9 × 10⁶ vs 72.4 ± 7.7 × 10⁶ area under the curve; <em>P</em> &lt; .05). Similarly, the NAD⁺ salvage pathway gene expression was increased in CGL^Tg gastrocnemius muscle. Finally, CGL overexpression or supplementation with the NAD⁺ precursor nicotinamide mononucleotide improved EC migration in vitro (wound closure: control, 35% ± 9%; CGL, 55% ± 11%; nicotinamide mononucleotide, 42% ± 13%; <em>P</em> &lt; .05).</p></div><div><h3>Conclusions</h3><p>Our results have demonstrated that CGL overexpression improves the neovascularization of skeletal muscle on hindlimb ischemia. These effects correlated with changes in the NAD pathway, which improved EC migration.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9369038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}