Shiraz Mohammed Ahmed, Ban Mousa Rashid, Lana Mustafa Haji Kareim, Sakar Karem Abdulla, Jamal Mahmood Salih, Beston Faiek Nore
Background: Diabetes mellitus is a serious metabolic disorder of multiple etiologies manifested by chronic hyperglycemia. The type 2 diabetes mellitus is characterized as multifactorial genetic syndrome, induced by mutations of different genes and environmental factors. Circulating homocysteine, a non- essential amino acid containing sulfur, is a broad biochemical marker for health/disease status diagnostics. The aim of our study is to evaluate circulating serum homocysteine levels in type 2 diabetes mellitus patients. Method: A cohort of 197 individuals randomly identified for this study. Of those, 148 individuals were diagnosed by consultants as type 2 diabetes mellitus and the rest 49 volunteer were normal controls group. In clinical chemistry laboratory, serum samples were analyzed for serum homocysteine, fasting blood sugar, glycated hemoglobin, serum creatinine, blood urea, blood urea nitrogen and lipid profile. Results: There was a significant difference in the HbA1c and sugar level between type 2 diabetes mellitus patients and control group. There was non-significant (P-value=0.32), the serum level of homocysteine was (13.6 ± 4.8, 12.5 ± 5.0 and 12.7 ± 6.2) in T2DM glycemic (controlled, poorly controlled and un controlled), respectively and (11.4 ± 4.8) in control group. Conclusions: Serum level of homocysteine was not differed significantly in type 2 diabetes mellitus when compared with control group. According to ages of T2DM and control group, there was no significant difference in serum level of homocysteine. There was significant difference between male and female in the level of serum homocysteine in glycemic uncontrolled group.
{"title":"Association of Serum Homocysteine with Controlled and Uncontrolled Type2 Diabetes Mellitus in Sulaimani City","authors":"Shiraz Mohammed Ahmed, Ban Mousa Rashid, Lana Mustafa Haji Kareim, Sakar Karem Abdulla, Jamal Mahmood Salih, Beston Faiek Nore","doi":"10.32947/ajps.v22i2.834","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.834","url":null,"abstract":"Background: Diabetes mellitus is a serious metabolic disorder of multiple etiologies manifested by chronic hyperglycemia. The type 2 diabetes mellitus is characterized as multifactorial genetic syndrome, induced by mutations of different genes \u0000 \u0000and environmental factors. Circulating homocysteine, a non- essential amino acid containing sulfur, is a broad biochemical marker for health/disease status diagnostics. The aim of our study is to evaluate circulating serum homocysteine levels in type 2 diabetes mellitus patients. \u0000Method: A cohort of 197 individuals randomly identified for this study. Of those, 148 individuals were diagnosed by consultants as type 2 diabetes mellitus and the rest 49 volunteer were normal controls group. In clinical chemistry laboratory, serum samples were analyzed for serum homocysteine, fasting blood sugar, glycated hemoglobin, serum creatinine, blood urea, blood urea nitrogen and lipid profile. \u0000Results: There was a significant difference in the HbA1c and sugar level between type 2 diabetes mellitus patients and control group. There was non-significant (P-value=0.32), the serum level of homocysteine was (13.6 ± 4.8, 12.5 ± 5.0 and 12.7 ± 6.2) in T2DM glycemic (controlled, poorly controlled and un controlled), respectively and (11.4 ± 4.8) in control group. \u0000Conclusions: Serum level of homocysteine was not differed significantly in type 2 diabetes mellitus when compared with control group. According to ages of T2DM and control group, there was no significant difference in serum level of homocysteine. There was significant difference between male and female in the level of serum homocysteine in glycemic uncontrolled group.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88802062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. B. Qasim, G. A. Jasim, Ihsan Rabeea, مساق تجهب, يلع ثيغ, عيبر حلاص ناسحا
Acute kidney injury (AKI), formly known as acute renal failure (ARF), is an abrupt and reversible decrease in kidney function as indicated by the glomerular filtration rate (GFR). Diclofenac-induced AKI is due to toxic effect of it on renal glomeruli, resulting in glomerular lesions. Furthermore, diclofenac causes autolysis, which increase renal intracellular osmolarity that leads to proximal renal tubular dilatations. Lipoic acid (LA) has antioxidant and anti-inflammatory activities. Bosentan is a competitive endothelin A (ETA) and endothelin B (ETB) receptors antagonist. In this study, the evaluation of effectiveness of lipoic acid and bosentan against diclofenac-induced AKI was done by histopathological examination. The results showed that diclofenac caused histopathological changes include; retracted glomerulus, tubular cast, tubule-interstitial inflammation and tubular necrosis. Lipoic acid or bosentan alone could not reduce the histopathological alterations caused by diclofenac. Meanwhile, the combination therapy was able to reduce the histopathological changes significantly (p>0.05). Therefore, the combination therapy of lipoic acid and bosentan showed promising ameliorative effect against diclofenac-induced AKI
{"title":"Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats","authors":"L. B. Qasim, G. A. Jasim, Ihsan Rabeea, مساق تجهب, يلع ثيغ, عيبر حلاص ناسحا","doi":"10.32947/ajps.v22i1.829","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.829","url":null,"abstract":"Acute kidney injury (AKI), formly known as acute renal failure (ARF), is an abrupt and reversible decrease in kidney function as indicated by the glomerular filtration rate (GFR). Diclofenac-induced AKI is due to toxic effect of it on renal glomeruli, resulting in glomerular lesions. \u0000Furthermore, diclofenac causes autolysis, which increase renal intracellular osmolarity that leads to proximal renal tubular dilatations. Lipoic acid (LA) has antioxidant and anti-inflammatory activities. Bosentan is a competitive endothelin A (ETA) and endothelin B (ETB) receptors antagonist. In this study, the evaluation of effectiveness of lipoic acid and bosentan against diclofenac-induced AKI was done by histopathological examination. The results showed that diclofenac caused histopathological changes include; retracted glomerulus, tubular cast, tubule-interstitial inflammation and tubular necrosis. Lipoic acid or bosentan alone could not reduce the histopathological alterations caused by diclofenac. Meanwhile, the combination therapy was able to reduce the histopathological changes significantly (p>0.05). Therefore, the combination therapy of lipoic acid and bosentan showed promising ameliorative effect against diclofenac-induced AKI","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86750911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. O. Farooq, N. Mohammed, ديمح ةيدان،, ةحصلا ،دادغب, ةرازو, لوتلاب ةهيبشلا, تلابقتسملا ،ليربوتباكلا, ،يمزيتامورلا لصافملا
Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2.
类风湿性关节炎(RA)是一种自身免疫性炎症性疾病，首先影响关节，然后发展为全身性疾病。Toll样受体(Toll like receptor, TLR)在本病的发生发展中起重要作用。卡托普利是一种血管紧张素酶抑制剂(ACEI)，广泛用于控制血压升高。该药具有抗炎活性，因此我们试图研究其在RA中的作用。在本研究中我们发现卡托普利降低了TLR2的表达和强度。
{"title":"Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis","authors":"A. O. Farooq, N. Mohammed, ديمح ةيدان،, ةحصلا ،دادغب, ةرازو, لوتلاب ةهيبشلا, تلابقتسملا ،ليربوتباكلا, ،يمزيتامورلا لصافملا","doi":"10.32947/ajps.v22i1.825","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.825","url":null,"abstract":"Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin \u0000enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2. \u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87519465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
May Mohammed Jawad Al-Mudhafar, Tagreed N-A Omar, Shayma L. Abdulhadi
Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations can lead to new molecular modifications that result in compounds with more desirable pharmacological properties
{"title":"Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review","authors":"May Mohammed Jawad Al-Mudhafar, Tagreed N-A Omar, Shayma L. Abdulhadi","doi":"10.32947/ajps.v22i1.827","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.827","url":null,"abstract":"Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations can lead to new molecular modifications that result in compounds with more desirable pharmacological properties","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87973130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and drug resistance to currently available treatments. Previous studies showed that a high intake of Brassica vegetables has been associated to a decreased risk of a number of malignancies. The aim of this study is the evaluation of antiproliferative activity of Brassica nigra seeds extract in mice exposed to phenobarbital. Brassica nigra seeds where extracted; phytochemical analysis of the extract was done that including phytochemical screening tests and Gas chromatography-mass spectrometry (GC-MS) analysis. Antiproliferative activity of hydro alcoholic Brassica seeds extract has been studied by 800mg/kg and compare with control group (given normal saline), phenobarbital group (Phenobarbital 75mg/kg) and combination group (Brassica extract 800mg/kg+ Phenobarbital 75mg/kg). The GC-MS analysis revealed the presence of isothiocynate compound. Histologically phenobarbital induced severe hepatocellular proliferation (hyperplasia and hypertrophy), glass ground cytoplasm, while Brassica seeds extract produce improvement in histopathological changes that include mild scattered proliferation picture and eosinophilic cytoplasm. In comparison to phenobarbital group, Combination groups pretreated with Brassica nigra seeds for 14 days and phenobarbital for 7 days caused significant reduction relative liver weight and alanine aminotransferase (ALT) Brassica nigra seeds extract have isothiocynate as main compound it showed antiproliferative action on the liver tissue, implying that it may have a promising effect in minimizing the risk of liver cancer.
{"title":"Antiproliferative activity of Brassica nigra seeds extract in liver tissue of mice exposed to phenobarbital","authors":"Ibtehal Naseer Salman, Dalya Basil Hanna, Bahir Abdul-Razzaq Mshimesh","doi":"10.32947/ajps.v22i1.826","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.826","url":null,"abstract":"Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and drug resistance to currently available \u0000treatments. Previous studies showed that a high intake of Brassica vegetables has been associated to a decreased risk of a number of malignancies. The aim of this study is the evaluation of antiproliferative activity of Brassica nigra seeds extract in mice exposed to phenobarbital. Brassica nigra seeds where extracted; phytochemical analysis of the extract was done that including phytochemical screening tests and Gas chromatography-mass spectrometry (GC-MS) analysis. Antiproliferative activity of hydro alcoholic Brassica seeds extract has been studied by 800mg/kg and compare with control group (given normal saline), phenobarbital group (Phenobarbital 75mg/kg) and combination group (Brassica extract 800mg/kg+ Phenobarbital 75mg/kg). The GC-MS analysis revealed the presence of isothiocynate compound. Histologically phenobarbital induced severe hepatocellular proliferation (hyperplasia and hypertrophy), glass ground cytoplasm, while Brassica seeds extract produce improvement in histopathological changes that include mild scattered proliferation picture and eosinophilic cytoplasm. In comparison to phenobarbital group, Combination groups pretreated with Brassica nigra seeds for 14 days and phenobarbital for 7 days caused significant reduction relative liver weight and alanine aminotransferase (ALT) Brassica nigra seeds extract have isothiocynate as main compound it showed antiproliferative action on the liver tissue, implying that it may have a promising effect in minimizing the risk of liver cancer.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79930903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized by reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form tetrahydrocarbazole (THCZ), where the latter is reacted with NSAID (Ketoprofen) via amide bond to yield substituted THCZ, compounds chemical structures were verified by: 1H, 13C NMR and FTIR spectroscopy. Antifungal activity of the synthesized compounds was investigated by docking study and in vitro test to reveal good antifungal activity, but the in vitro test also showed that the compounds have weak to moderate antibacterial activity.
{"title":"Synthesis and study of antimicrobial activity of some tetrahydrocarbazole derivatives substituted with NSAID","authors":"Mustafa H. Mahdi, A. Dawood, D. Q. Shaheed","doi":"10.32947/ajps.v22i2.857","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.857","url":null,"abstract":"New tetrahydrocarbazole derivatives substituted at the heteroatom (N) by non-steroidal anti-inflammatory drug (NSAIDs) were synthesized by reaction of cyclohehexanon (C.H.N.) with phenyl hydrazine (P.H.Z.) to form tetrahydrocarbazole (THCZ), where the latter is reacted with NSAID (Ketoprofen) via amide bond to yield \u0000substituted THCZ, compounds chemical structures were verified by: 1H, 13C NMR and FTIR spectroscopy. \u0000Antifungal activity of the synthesized compounds was investigated by docking study and in vitro test to reveal good antifungal activity, but the in vitro test also showed that the compounds have weak to moderate antibacterial activity.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73903945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rana Hussein Kutaif, Mustafa G. Alabbassi, Weqar Akram Hussein, Zainab Faleh Ali, Shatha Khayun Jassim
Abdominal fat synthesizes a variety of adipokines, including vaspin and chemerin, that affect the resistance to insulin. This research was conducted to demonstrate the effect of pioglitazone, one insulin sensitizer used to decrease insulin resistance, on these adipokines in obese patients with polycystic ovary (PCOS). Twenty-five obese women with PCOS were treated with pioglitazone 15mg/bid for 12 weeks. Modifications in fasting blood glucose (FBG), serum fasting insulin (FSI), chemerin and vaspin serum levels, follicle stimulation hormone (FSH), luteinizing hormone (LH), testosterone (T), and in baseline and post-therapy were assessed. Body mass index decreased without any substantial variance after 12 weeks of pioglitazone therapy (P> 0.05). T, FSI, HOMA-IR, LH, and FBG levels have decreased considerably (P≤0.01, P≤0.05) after the therapy. No substantial variations were found in FSH (P>0.05). Serum chemerin and vaspin levels were observed no significant difference than before treatment (P>0.05) in obese women with polycystic ovarian syndrome cases.
{"title":"Effect of pioglitazone treatment on serum chemerin and vaspin levels in polycystic ovary syndrome.","authors":"Rana Hussein Kutaif, Mustafa G. Alabbassi, Weqar Akram Hussein, Zainab Faleh Ali, Shatha Khayun Jassim","doi":"10.32947/ajps.v21i1.789","DOIUrl":"https://doi.org/10.32947/ajps.v21i1.789","url":null,"abstract":"Abdominal fat synthesizes a variety of adipokines, including vaspin and chemerin, that affect the resistance to insulin. This research was conducted to demonstrate the effect of pioglitazone, one insulin sensitizer used to decrease insulin resistance, on these adipokines in \u0000 \u0000obese patients with polycystic ovary (PCOS). Twenty-five obese women with PCOS were treated with pioglitazone 15mg/bid for 12 weeks. Modifications in fasting blood glucose (FBG), serum fasting insulin (FSI), chemerin and vaspin serum levels, follicle stimulation hormone (FSH), luteinizing hormone (LH), testosterone (T), and in baseline and post-therapy were assessed. Body mass index decreased without any substantial variance after 12 weeks of pioglitazone therapy (P> 0.05). T, FSI, HOMA-IR, LH, and FBG levels have decreased considerably (P≤0.01, P≤0.05) after the therapy. No substantial variations were found in FSH (P>0.05). Serum chemerin and vaspin levels were observed no significant difference than before treatment (P>0.05) in obese women with polycystic ovarian syndrome cases.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74489784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacterial diseases are an important cause of mortality and morbidity worldwide. The Improper and uncontrolled use of antibiotics contribute to the bacterial resistance to antibiotics. It is well known that the antibiotics stop bacterial infections by killing or inhibiting their growth. Antibiotics are interfering with critical functions that are important for bacterial growth. To overcome this, bacteria developed different mechanisms to resist the antibiotics and survive. Targeting bacterial function without killing them is a promising way to inhibit bacterial infection. Bacterial adherence is a serious step towards infection. Anti –adhesion therapy aims to inhibit bacterial infection via interfering with bacterial attachment without killing them. This review will cover different strategies in anti-adhesion therapy.
{"title":"Strategies in anti-adhesion therapy: A review article","authors":"Fitua Al-Saedi","doi":"10.32947/ajps.v21i1.799","DOIUrl":"https://doi.org/10.32947/ajps.v21i1.799","url":null,"abstract":"Bacterial diseases are an important cause of mortality and morbidity worldwide. The Improper and uncontrolled use of antibiotics contribute to the bacterial resistance to antibiotics. \u0000It is well known that the antibiotics stop bacterial infections by killing or \u0000 \u0000inhibiting their growth. Antibiotics are interfering with critical functions that are important for bacterial growth. To overcome this, bacteria developed different mechanisms to resist the antibiotics and survive. \u0000Targeting bacterial function without killing them is a promising way to inhibit bacterial infection. Bacterial adherence is a serious step towards infection. Anti –adhesion therapy aims to inhibit bacterial infection via interfering with bacterial attachment without killing them. \u0000This review will cover different strategies in anti-adhesion therapy.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87157152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fadwa Ghassan Hameed, Inam Sameh Arif, Mohammed Mahmood Mohammed, Hala S. Arif
Unusual cases of coexistence between Wilson's disease and autoimmune hepatitis have occurred. There are characteristics of both diseases in this community of patients, and laboratory and histo pathological findings can be misleading. Wilson disease's clinical appearance can differ widely; thus, there is not always an easy diagnosis. In addition to being childhood and young adult illnesses, Wilson's disease can also be triggered at any age. Liver disease and cirrhosis, neuropsychiatric disorders, Kayser-Fleischer(KF.) rings, and acute hemolysis events are the primary characteristics of Wilson's disease, frequently in combination with acute liver failure. Diagnosis is extremely difficult for children and adults with active liver disease. None of the latest Wilson's disease laboratory tests are optimal and may not be specific. Therefore, by taking into account acute hepatitis similar to Wilson's disease and autoimmune hepatitis, concomitant treatment with immunosuppression and penicillamine may have a superior impact.
{"title":"Co-occurrence of Wilson disease and Auto-Immune Hepatitis in 14-year-old female: A case report","authors":"Fadwa Ghassan Hameed, Inam Sameh Arif, Mohammed Mahmood Mohammed, Hala S. Arif","doi":"10.32947/ajps.v21i2.803","DOIUrl":"https://doi.org/10.32947/ajps.v21i2.803","url":null,"abstract":"Unusual cases of coexistence between Wilson's disease and autoimmune hepatitis have occurred. There are characteristics of both diseases in this community of patients, and laboratory and histo pathological findings can be misleading. Wilson disease's clinical appearance can differ widely; thus, \u0000there is not always an easy diagnosis. In addition to being childhood and young adult illnesses, Wilson's disease can also be triggered at any age. Liver disease and cirrhosis, neuropsychiatric disorders, Kayser-Fleischer(KF.) rings, and acute hemolysis events are the primary characteristics of Wilson's disease, frequently in combination with acute liver failure. Diagnosis is extremely difficult for children and adults with active liver disease. None of the latest Wilson's disease laboratory tests are optimal and may not be specific. Therefore, by taking into account acute hepatitis similar to Wilson's disease and autoimmune hepatitis, concomitant treatment with immunosuppression and penicillamine may have a superior impact.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86470147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noor Wafaa Hashim, Kadhim Ali Kadhim, Abbas Mahdi Rahmah
Background: Both human insulin and insulin analogue used in the treatment of type 1 diabetes mellitus. The modification in amino acids sequences of human insulin lead to produce analogue form which have a pharmacokinetic and pharmacodynamics effect near to normal human endogenous insulin release. Aim of study: This study designed to compare between the effect of each type of insulin on high sensitive C-reactive protein and interleukin-6 and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents. Study design: The study was enrolled on fifty-one Iraqi type 1 diabetic children and adolecence age range (6-18) year. The patients allocated into two groups, Group (1) includes 20 patients assigned to receive conventional human insulin (regular and NPH), and Group (2) includes 20 patients assigned to receive insulin analogue (insulin aspart and glargine) for three months. The inflammatory and antioxidant markers measured at baseline and after three months of intervention. Results: After three months of treatment, both insulin groups did not affect high sensetive C_reactive protein (hs-CRP) significantly from baseline to 3 months. Only insulin analogue reduced Interleukin-6 (IL-6) significantly, while human insulin reduced level of IL-6 but it was not statistically significant. Both therapies reduced total antioxidant capacity (TAOC) significantly; however, insulin analogue had higher reduction percentage (15.1% vs. 5.7%) compared to the conventional insulin. Conclusion: Only insulin analogue reduced IL-6 significantly. Both types of insulins did not effect on hs-CRP. Both therapies reduce TAOC significantly.
背景:人胰岛素和胰岛素类似物均用于1型糖尿病的治疗。通过对人胰岛素氨基酸序列的修饰，产生了类似的胰岛素，其药代动力学和药效学效应接近于正常的人内源性胰岛素释放。研究目的:本研究旨在比较伊拉克1型糖尿病儿童和青少年样本中每种胰岛素对高敏c反应蛋白和白细胞介素-6以及总抗氧化能力的影响。研究设计:本研究纳入51名伊拉克1型糖尿病儿童和青少年(6-18岁)。患者被分为两组，组(1)包括20名患者接受常规人胰岛素(常规和非ph)，组(2)包括20名患者接受胰岛素类似物(胰岛素分离和甘精)，为期3个月。在基线和干预三个月后测量炎症和抗氧化标志物。结果:治疗3个月后，从基线到3个月，两组胰岛素对高敏C_reactive protein (hs-CRP)无显著影响。只有胰岛素类似物能显著降低白细胞介素-6 (IL-6)水平，而人胰岛素能降低IL-6水平，但无统计学意义。两种疗法均显著降低总抗氧化能力(TAOC);然而，与传统胰岛素相比，胰岛素类似物具有更高的降低百分比(15.1%对5.7%)。结论:仅胰岛素类似物可显著降低IL-6。两种胰岛素对hs-CRP均无影响。两种疗法均可显著降低TAOC。
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