Pub Date : 2023-01-01DOI: 10.5455/pbs.20221021062041
Vusala Novruzova, Ali Erdoğan, Yusuf Hor, B. Kulaksızoğlu
Objective: It was aimed to investigate internalized stigma, self-esteem, suicide probability, and loneliness in patients with alcohol use disorder (AUD) in remission. Methods: Fifty patients diagnosed with AUD according to DSM-5 diagnostic criteria and 50 healthy volunteers were included in the study. The Structured Clinical Interview for DSM-5 (SCID-5), Suicide Probability Scale (SPS), Rosenberg Self-Esteem Scale (RSS), and University of California Los Angeles Loneliness Scale (UCLA-LS) were administered to all participants. In addition, Internalized Stigma of Mental Illness Scale (ISMIS) was applied to the AUD group. Results: UCLA-LS scores were found to be significantly higher in the AUD group than the control group (p=0.014). RSS scores were found to be significantly lower in the AUD group compared to the control group (p=0.019). The SPS total score and all subscale scores were similar in the AUD group and healthy controls (for all; p>0.05). In the AUD group, as ISMIS scores increased, SPS scores and UCLA-LS scores increased (respectively; p=0.022, p=0.003), while as UCLA-LS scores increased, SPS scores increased and RSS scores decreased (respectively; p=0.005, p=0.001). In the regression analysis, loneliness predicts the probability of suicide in AUD patients. Conclusion: It can be said that even if AUD patients are in remission, they have lower self-esteem and higher levels of loneliness, and the probability of suicide is not different from healthy controls. In addition, it can be said that as internalized stigma increases in AUD patients, the level of loneliness and the possibility of suicide increase.
目的:探讨酒精使用障碍(AUD)缓解期患者的内化污名、自尊、自杀概率和孤独感。方法:选取50例符合DSM-5诊断标准的AUD患者和50名健康志愿者作为研究对象。采用DSM-5结构化临床访谈(SCID-5)、自杀概率量表(SPS)、Rosenberg自尊量表(RSS)和加州大学洛杉矶分校孤独量表(UCLA-LS)对所有参与者进行问卷调查。此外，对AUD组采用心理疾病内化污名量表(ISMIS)。结果:AUD组UCLA-LS评分明显高于对照组(p=0.014)。与对照组相比，AUD组的RSS评分显著降低(p=0.019)。AUD组和健康对照组的SPS总分和所有子量表得分相似(所有;p > 0.05)。在AUD组，随着ISMIS评分的升高，SPS评分和UCLA-LS评分分别升高(;p=0.022, p=0.003)，而随着UCLA-LS评分的升高，SPS评分升高，RSS评分降低(分别为;p = 0.005, p = 0.001)。在回归分析中，孤独感可以预测AUD患者的自杀概率。结论:可以说，即使AUD患者处于缓解期，其自尊水平较低，孤独感水平较高，自杀概率与健康对照无明显差异。此外，可以说，随着AUD患者内化耻辱感的增加，孤独感的水平和自杀的可能性也会增加。
{"title":"Internalized Stigma, Self-Esteem, Loneliness, and Suicide Probability in Patients with Alcohol Use Disorder in Remission","authors":"Vusala Novruzova, Ali Erdoğan, Yusuf Hor, B. Kulaksızoğlu","doi":"10.5455/pbs.20221021062041","DOIUrl":"https://doi.org/10.5455/pbs.20221021062041","url":null,"abstract":"Objective: It was aimed to investigate internalized stigma, self-esteem, suicide probability, and loneliness in patients with alcohol use disorder (AUD) in remission. Methods: Fifty patients diagnosed with AUD according to DSM-5 diagnostic criteria and 50 healthy volunteers were included in the study. The Structured Clinical Interview for DSM-5 (SCID-5), Suicide Probability Scale (SPS), Rosenberg Self-Esteem Scale (RSS), and University of California Los Angeles Loneliness Scale (UCLA-LS) were administered to all participants. In addition, Internalized Stigma of Mental Illness Scale (ISMIS) was applied to the AUD group. Results: UCLA-LS scores were found to be significantly higher in the AUD group than the control group (p=0.014). RSS scores were found to be significantly lower in the AUD group compared to the control group (p=0.019). The SPS total score and all subscale scores were similar in the AUD group and healthy controls (for all; p>0.05). In the AUD group, as ISMIS scores increased, SPS scores and UCLA-LS scores increased (respectively; p=0.022, p=0.003), while as UCLA-LS scores increased, SPS scores increased and RSS scores decreased (respectively; p=0.005, p=0.001). In the regression analysis, loneliness predicts the probability of suicide in AUD patients. Conclusion: It can be said that even if AUD patients are in remission, they have lower self-esteem and higher levels of loneliness, and the probability of suicide is not different from healthy controls. In addition, it can be said that as internalized stigma increases in AUD patients, the level of loneliness and the possibility of suicide increase.","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90791630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.33582/mppbs.2022.202211002
Damian D. Osa-Afiana
This study examined dimensions of stress among sample of selected Nigerian Navy personnel in Lagos, Calabar, Jaji, in Kaduna Nigeria.
本研究考察了尼日利亚卡杜纳拉各斯、卡拉巴尔、贾吉等地选定的尼日利亚海军人员的压力维度。
{"title":"Dimensions of Operational Stress in the Nigerian Navy: Selected Samples of Combatant, Artisan and Retired Naval Personnel in Nigeria","authors":"Damian D. Osa-Afiana","doi":"10.33582/mppbs.2022.202211002","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202211002","url":null,"abstract":"This study examined dimensions of stress among sample of selected Nigerian Navy personnel in Lagos, Calabar, Jaji, in Kaduna Nigeria.","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88714226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.33582/mppbs.2022.202211004
Aamir Jalal Al-Mosawi
Background: Autism disorders which are also known pervasive developmental disorders as are very complex and heterogeneous group of chronic disorders that marked by early impairment in socialization, communication, and behavior
{"title":"A Girl from Pakistan with atypical Autism:Expert Opinion and a Therapeutic Recommendation","authors":"Aamir Jalal Al-Mosawi","doi":"10.33582/mppbs.2022.202211004","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202211004","url":null,"abstract":"Background: Autism disorders which are also known pervasive developmental disorders as are very complex and heterogeneous group of chronic disorders that marked by early impairment in socialization, communication, and behavior","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"188 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76618652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.33582/mppbs.2022.202211001
Dennis Uba Donald, Owoseni Sulaimon Kayode
The study examined core self–evaluation as predicates of clinical decision making in selected sample of perioperative nurses in Ondo State Nigeria.
该研究检查了核心自我评价作为临床决策的谓词在选定的样本围手术期护士在尼日利亚翁多州。
{"title":"Core Self–Evaluations as Predicates of Clinical Decision Making in Selected Team of Perioperative Nurses in Ondo State, Nigeria","authors":"Dennis Uba Donald, Owoseni Sulaimon Kayode","doi":"10.33582/mppbs.2022.202211001","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202211001","url":null,"abstract":"The study examined core self–evaluation as predicates of clinical decision making in selected sample of perioperative nurses in Ondo State Nigeria.","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"55 36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90040696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-31DOI: 10.33582/mppbs.2022.202209011
S. Batchu, Michael Joseph Diaz, B. Lucke-Wold
Background Accumulating evidence suggests overexpression of Eph receptors is associated with malignant human gliomas. Inhibiting interactions of Eph receptors with their ephrin ligands may improve clinical outcomes in glioma patients. The present study investigated the potential of cannabinoids to bind Eph receptors and block Eph/ephrin interactions. Methods Twelve major cannabinoids were computationally docked with ligand binding domains from six glioma-associated Eph receptors through Auto Dock Vina to measure their potential binding affinities. The molecular structures and residue interactions of the most favorable poses for each receptor binding domain were further visually examined. Results Cannabichromene (CBC) exhibited the most favorable binding with EphA2, EphA3, and EphB4 receptor ligand binding domains while tetrahydrocannabinol (THC) was predicted to bind favorably with EphB2 and EphB3 receptor ligand binding domains. EphA4 showed the best potential binding affinity with cannabidivarin (CBDV). Further analysis revealed that these cannabinoids bind to specific locations on Eph receptors required for Eph/ephrin interactions. Conclusion The findings suggest that certain cannabinoids can effectively bind to hydrophobic pockets required for ephrin binding and thereby be used to block subsequent Eph/ephrin interactions.
背景越来越多的证据表明，Eph受体的过度表达与人类恶性胶质瘤有关。抑制Eph受体与其ephrin配体的相互作用可能改善胶质瘤患者的临床预后。本研究探讨了大麻素结合Eph受体和阻断Eph/ephrin相互作用的潜力。方法通过Auto Dock Vina计算12种主要大麻素与6种胶质瘤相关Eph受体的配体结合域对接，测量它们的潜在结合亲和力。进一步目测了每个受体结合域最有利姿态的分子结构和残基相互作用。结果scan - abichromene (CBC)与EphA2、EphA3和EphB4受体结合域的结合效果最好，而四氢大麻酚(THC)与EphB2和EphB3受体结合域的结合效果最好。EphA4与大麻二酚(cannabidivarin, CBDV)的结合亲和力最强。进一步分析表明，这些大麻素结合到Eph/ephrin相互作用所需的Eph受体上的特定位置。结论某些大麻素可以有效结合到ephrin结合所需的疏水袋上，从而阻断Eph/ephrin随后的相互作用。
{"title":"In Silico Binding Analysis of Cannabinoids with Eph Receptors for Therapeutic Use in Gliomas.","authors":"S. Batchu, Michael Joseph Diaz, B. Lucke-Wold","doi":"10.33582/mppbs.2022.202209011","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202209011","url":null,"abstract":"Background\u0000Accumulating evidence suggests overexpression of Eph receptors is associated with malignant human gliomas. Inhibiting interactions of Eph receptors with their ephrin ligands may improve clinical outcomes in glioma patients. The present study investigated the potential of cannabinoids to bind Eph receptors and block Eph/ephrin interactions.\u0000\u0000\u0000Methods\u0000Twelve major cannabinoids were computationally docked with ligand binding domains from six glioma-associated Eph receptors through Auto Dock Vina to measure their potential binding affinities. The molecular structures and residue interactions of the most favorable poses for each receptor binding domain were further visually examined.\u0000\u0000\u0000Results\u0000Cannabichromene (CBC) exhibited the most favorable binding with EphA2, EphA3, and EphB4 receptor ligand binding domains while tetrahydrocannabinol (THC) was predicted to bind favorably with EphB2 and EphB3 receptor ligand binding domains. EphA4 showed the best potential binding affinity with cannabidivarin (CBDV). Further analysis revealed that these cannabinoids bind to specific locations on Eph receptors required for Eph/ephrin interactions.\u0000\u0000\u0000Conclusion\u0000The findings suggest that certain cannabinoids can effectively bind to hydrophobic pockets required for ephrin binding and thereby be used to block subsequent Eph/ephrin interactions.","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89893424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-29DOI: 10.33582/mppbs.2022.202209010
Anu Bajaj
Carcinoma cervix is an invasive epithelial neoplasm comprised of neoplastic cells demonstrating varying degrees of squamous differentiation.
宫颈癌是一种侵袭性上皮性肿瘤，由肿瘤细胞组成，表现出不同程度的鳞状分化。
{"title":"Deviant and Heretical–Carcinoma Cervix","authors":"Anu Bajaj","doi":"10.33582/mppbs.2022.202209010","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202209010","url":null,"abstract":"Carcinoma cervix is an invasive epithelial neoplasm comprised of neoplastic cells demonstrating varying degrees of squamous differentiation.","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87883174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.33582/mppbs.2022.202209006
Aamir Jalal Al-Mosawi
Background: We have previously reported our extensive experiences with autism disorders and their treatments, and we showed the possibility of curing the major autistic features with a new therapeutic approach
{"title":"Atypical Genetic Autism: Cure of the Major Autistic Features and the Need for Cognitive Improvement and Rehabilitation","authors":"Aamir Jalal Al-Mosawi","doi":"10.33582/mppbs.2022.202209006","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202209006","url":null,"abstract":"Background: We have previously reported our extensive experiences with autism disorders and their treatments, and we showed the possibility of curing the major autistic features with a new therapeutic approach","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80512564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.33582/mppbs.2022.202209004
Aamir Jalal Al-Mosawi
The increasing complexity of medical care environment and medical education and practices has made the understanding the principles and concepts of training, development, and the related concepts and disciplines necessary for doctors practicing at almost any level
{"title":"Principles of Training and Development for Physicians","authors":"Aamir Jalal Al-Mosawi","doi":"10.33582/mppbs.2022.202209004","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202209004","url":null,"abstract":"The increasing complexity of medical care environment and medical education and practices has made the understanding the principles and concepts of training, development, and the related concepts and disciplines necessary for doctors practicing at almost any level","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89183426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.33582/mppbs.2022.202209008
Aamir Jalal Al-Mosawi
Background: Autism disorders which are also known pervasive developmental disorders as are very complex and heterogeneous
背景:自闭症障碍也被称为广泛性发育障碍，是非常复杂和异质性的
{"title":"Catatonia: A Rare Manifestation of Autism","authors":"Aamir Jalal Al-Mosawi","doi":"10.33582/mppbs.2022.202209008","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202209008","url":null,"abstract":"Background: Autism disorders which are also known pervasive developmental disorders as are very complex and heterogeneous","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86188328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.33582/mppbs.2022.202209007
Aamir Jalal Al-Mosawi
Background: We have previously reported the very rare sporadic occurrence of periventricular white matter hyperintensity on brain magnetic resonance imaging with atypical neuropsychiatric
背景:我们以前报道过非常罕见的散发性脑室周围白质高磁共振成像与非典型神经精神
{"title":"Cerebral Palsy and Autism Associated With Periventricular White Matter Hyperintensity on Brain Magnetic Resonance Imaging: A New Disorder and Its Treatment","authors":"Aamir Jalal Al-Mosawi","doi":"10.33582/mppbs.2022.202209007","DOIUrl":"https://doi.org/10.33582/mppbs.2022.202209007","url":null,"abstract":"Background: We have previously reported the very rare sporadic occurrence of periventricular white matter hyperintensity on brain magnetic resonance imaging with atypical neuropsychiatric","PeriodicalId":74168,"journal":{"name":"MedPress psychiatry and behavioral sciences","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86900305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：